|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
16-391 |
3.53e-95 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 289.83 E-value: 3.53e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 16 FVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDtHHFNRKIIIILALLMGALGFSI 95
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSD-RGGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 96 YFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDrAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLF 175
Cdd:cd17471 80 FAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRD-ATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 176 GGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPnmfKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQ 255
Cdd:cd17471 159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAP---VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSES 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 256 HVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQD 335
Cdd:cd17471 236 WVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 616690429 336 ILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIF 391
Cdd:cd17471 316 LMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
21-395 |
5.53e-32 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 124.50 E-value: 5.53e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHfNRKIIIILALLMGALGFSIYFFVD 100
Cdd:TIGR00899 7 FLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQG-DRKGLILFCCLLAALACLLFAWNR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 101 TIWLFILLYAIFQGLFAPAMPQLYASAREsiNVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTIS 180
Cdd:TIGR00899 86 NYFLLLVLGVLLSSFASTANPQLFALARE--HADRTGREAVMFSSVMRAQISLAWVIGPPLAFWLALGFGFTVMFLTAAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 181 IILFTLVLQVFFYKDLNIKHPISTQQhveKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYL 260
Cdd:TIGR00899 164 AFVLCGVLVWLFLPSYPRGAPGALTR---LEVRGLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 261 ASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPDF 340
Cdd:TIGR00899 241 MGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPGR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 616690429 341 PGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFFTKN 395
Cdd:TIGR00899 321 AGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
15-350 |
4.11e-27 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 111.50 E-value: 4.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 15 LFVAnmFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHfNRKIIIILALLMGALGFS 94
Cdd:PRK15011 21 LIVA--FLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRG-DRKSLIVFCCLLGVLACT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 95 IYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKdrAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGL 174
Cdd:PRK15011 98 LFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGRE--AVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 175 FGGTISIILFTLVLQVFFYKDLNIKHPISTQQhVEkiAPNMFKDKTLLLpFIAFILLHIGQWMYTMNMPLFVTDYLKENE 254
Cdd:PRK15011 176 YLSAAVAFIVCGVMVWLFLPSMRKELPLATGT-LE--APRRNRRDTLLL-FVICTLMWGTNSLYIINMPLFIINELHLPE 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 255 QHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQ 334
Cdd:PRK15011 252 KLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIGILGGIGMLYFQ 331
|
330
....*....|....*.
gi 616690429 335 DILPDFPGYASTLFSN 350
Cdd:PRK15011 332 DLMPGQAGSATTLYTN 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-394 |
3.01e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 105.74 E-value: 3.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 16 FVANMFLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSI 95
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD--RFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 96 YFFVDTIWLFILLYAIFQGLFAPAMPQLYASAresINVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLF 175
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAAVWPAAMALI---ADIAPPEERGR-AMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 176 GGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPN--MFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKEN 253
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 254 EQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYF 333
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690429 334 QDILPDFP-GYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFFTK 394
Cdd:cd17325 314 ADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-352 |
1.66e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.35 E-value: 1.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 15 LFVANMFLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFS 94
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 95 IYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESInvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGL 174
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV----PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 175 FGGTISIILFTLVLQVFFYKDlnikHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENE 254
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPE----SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 255 QHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQ 334
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330
....*....|....*....
gi 616690429 335 DILPD-FPGYASTLFSNAM 352
Cdd:COG2814 323 ELAPPeARGRASGLYNSAF 341
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-320 |
4.43e-19 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 88.05 E-value: 4.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 17 VANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIY 96
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD--RFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 97 FFVDTIWLFILLYA---IFQGLFAPAMpqlYASAresINVSSSKDRAqFANTVLRSMFSLGFLFGPFIGAQLIGLkGYAG 173
Cdd:cd17329 83 GFAHSPWLFAIALVltgFGGGLFEPAS---EAMI---ADVTTPENRT-RAFSLLYWAINLGVAIGPLLGGLLLLY-SFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 174 LFGGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFIL--LHIGQWMYTMnmPLFVTDYLK 251
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLisLIYFQLESTL--PVYVVEILG 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616690429 252 ENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAI 320
Cdd:cd17329 233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL 301
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-338 |
5.38e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.53 E-value: 5.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFV 99
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFILLyAIFQGLFAPAMpqlYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTI 179
Cdd:pfam07690 83 SSLWLLLVL-RVLQGLGAGAL---FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 180 SIILFTLVLQVFFYKDLNIKHPISTQQ--HVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYlKENEQHV 257
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEarLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 258 GYLASLCAGLEVPFMIILGVLSSRLQTRTLL---IYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQ 334
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
....
gi 616690429 335 DILP 338
Cdd:pfam07690 318 DLAP 321
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-338 |
1.02e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.92 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 15 LFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFS 94
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD--RFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 95 IYFFVDTIWLFiLLYAIFQGLFAPAMpqlYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGL 174
Cdd:COG2223 86 LLALAVSYWLL-LLLGLLLGIGGGGS---FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 175 FGGTISIILFTLVLQVFFYKDLNiKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENE 254
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPP-AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 255 QHVGYLASLCAGLEVPFMIILGVLSSRLQ-TRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYF 333
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGgRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
....*
gi 616690429 334 QDILP 338
Cdd:COG2223 321 PDIFP 325
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-402 |
7.10e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.58 E-value: 7.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPyLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFsdTHHFNRKIIIILALLMGALGFSIYFFV 99
Cdd:COG0738 17 FFLWGFATALWGP-LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRL--IDRFGYKRGLLLGLLLMALGLLLFALA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFIL---LYAIFQGLFAPAMpQLYASAREsinvsssKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFG 176
Cdd:COG0738 94 PSYPLLLLalfLLGLGLGLLDVAA-NPYVAALG-------PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 177 G--TISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENE 254
Cdd:COG0738 166 PylILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 255 QHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQ 334
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616690429 335 DILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVssASIMLGMILIFFTKNQKITKED 402
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV--PLVCYLLILLLALALKRKRRKK 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-338 |
3.02e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.70 E-value: 3.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 8 LQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSD---THHFNRKIIIIL 84
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrTRWGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 85 ALLMGALGFSIYFFVDT------IWLFILLYAIFQGLFAPAMPQLYASARESinVSSSKDRAQfANTVLRSMFSLGFLFG 158
Cdd:COG2211 87 GAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAEL--TPDYEERTR-LSSWRFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 159 PFIGAQLIGL------KGYAGLFGGTISIILFTLVLQVFFYKDlnIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLH 232
Cdd:COG2211 164 SVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGTKE--RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 233 IGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFK--NFYM 310
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWL 321
|
330 340
....*....|....*....|....*...
gi 616690429 311 MLAGQVFLAIFLAVLLGIGISYFQDILP 338
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVD 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-391 |
4.41e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.15 E-value: 4.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFV 99
Cdd:cd06174 5 FFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTI 179
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 180 SIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAP--NMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHV 257
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 258 GYLASLCAGLEVPFMIILGVLSSRLQTRTLLIY-GAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDI 336
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLiGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 616690429 337 LPdfPGYASTLFSNAMVIGQLGGNLLGGAMSHWV----GLENVFFVSSASIMLGMILIF 391
Cdd:cd06174 322 FP--PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaatfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
20-393 |
1.61e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.36 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFaTKDLGMTTNQY-----GLLLASAAISQFTVNSIIARFSDTHhfNRKIIIILALLMGALGFS 94
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLY-IEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRY--GRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 95 IYFFVDTIWLFILLyAIFQGLFA---PAMPQLYASaresinvSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGY 171
Cdd:cd17391 82 LMAFVTNVWQLLIL-RLLQGVFSgyvPNATALIAS-------QTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 172 AGLFGGTISIILFTLVLQVFFYKD----LNIKHPISTQQHVEKIapnmFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVT 247
Cdd:cd17391 154 RNVFFITGGLLFLAFLLTLFFVKEdfkpVEKKKMVSTKEVWNSV----PNPSLLISLFVTTFIIQLANQSIEPILTLYIR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 248 DyLKENEQHVGYLASLCAG-------LEVPFmiiLGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAI 320
Cdd:cd17391 230 Q-LMGDASNLAFISGLVFSatgvsslLSAPR---LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616690429 321 FLAVLLGIGISYFQDILPDfpGYASTLFS---NAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFFT 393
Cdd:cd17391 306 ATGGLLPAINSLLAKITPK--EVAGRIFGynqSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-392 |
2.02e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFV 99
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWGLATLLFGFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFILLYA---IFQGLFAPAMPQLyasaresINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFG 176
Cdd:COG2271 96 TSFWQLLLLRFllgLGEAGFFPAALKL-------IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 177 GTISIILFTLVLQVffykdlnikhpistqqhvekiapnmfkdktlLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQH 256
Cdd:COG2271 169 ILGLPGLLLALLRF-------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 257 VGYLASLCAGLEVPFMIILGVLSSRLQ--TRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQ 334
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 616690429 335 DILP-DFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFF 392
Cdd:COG2271 298 ELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-392 |
9.42e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 9.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 14 KLFVANMF-LLGMGIA-VTVPYLVLFATKDLGMTtnqyGLLLASAAISQFTVNSIIARFSDThhFNRKIIIIL-----AL 86
Cdd:cd06173 3 LLWLAQLLsALGDWIFtVALPWLVLQLTGSALLV----GLVLAAFFLPFLLFSPFAGVLADR--FDRRRLLILadllrAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 87 LMGALGFSIYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESInvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLI 166
Cdd:cd06173 77 LAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV----PKEQLVRANALNSLATQLARIIGPALGGLLV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 167 GLKGYAGLFGGTISIILFTLVLQVFFYKDL---NIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMP 243
Cdd:cd06173 153 ALLGPGGAFAINALSFLLSALLLLFIRRPPpaaPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 244 LFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLA 323
Cdd:cd06173 233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 324 VLLGIGISYFQDILPD-FPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFF 392
Cdd:cd06173 313 LFNVPLNTLLQLRVPDeLRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-325 |
2.74e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.36 E-value: 2.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFATK--DLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYF 97
Cdd:cd17330 5 VFLDALGFGIVFPVLPFYVREfnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSD--RYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 98 FVDTIWLFIL---LYAIFQGLFAPAmpQLYASAresinVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAQLIGLKGYA-- 172
Cdd:cd17330 83 LSRNLWLLFLarfLDGLTGGNVSVA--QAYIAD-----ITDEEERAK-AFGIISAAFGLGFILGPALGGFLSTPYGYAlp 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 173 GLFGGTISIILFTLVLqvffykdlnikhpistqqhvekiapnmFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKE 252
Cdd:cd17330 155 FLVAAALALLNLVLVL---------------------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGF 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616690429 253 NEQHVGYLASLC-AGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVL 325
Cdd:cd17330 208 SPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIV 281
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-193 |
4.00e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.97 E-value: 4.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 4 FAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDThhFNRKIIII 83
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR--IGRKPLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 84 LALLMGALGFSIYFFVDTIWLFILLYAIF---QGLFAPAMPQLYASAresinvsSSKDRAQFANTVLRSMFSLGFLFGPF 160
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLglgLGLVFPATLALLADI-------VPPEGRGTAMGLFNTAFSLGMVLGPL 342
|
170 180 190
....*....|....*....|....*....|...
gi 616690429 161 IGAQLIGLKGYAGLFGGTISIILFTLVLQVFFY 193
Cdd:cd17325 343 LGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
21-347 |
4.71e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFnRKIIIILALLMGALGFSIYFFVD 100
Cdd:cd17335 7 FFFFAALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGK-RKALLLLSLLAAVLFFLSLFFVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 101 TI-WLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDRAQfantvlRSMFSLGFLFGPFIGAQLI----GLKGYAGLF 175
Cdd:cd17335 85 QIfWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQ------RLWGSIGFGIAALLVGILIdrssTYKNYTIAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 176 gGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKiapNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDyLKENEQ 255
Cdd:cd17335 159 -YVFAVLMLLALLLALKFPFRPKHPEPNENTGGLL---ALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 256 HVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQD 335
Cdd:cd17335 234 LIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASA 313
|
330
....*....|..
gi 616690429 336 ILPdfPGYASTL 347
Cdd:cd17335 314 AAP--PGLRATA 323
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-394 |
6.81e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 6.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDThhFNRKIIIILALLMGALGFSIYFFV 99
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFI---LLYAIFQGLFAPAMPQLyasareSINVSSSKDRAQfaNTVLRSMF-SLGFLFGPFIGAQLIGLKGYAGLF 175
Cdd:cd17489 82 TSVALLLvlrLIHGIGWGAFTTAAATL------VADIIPPSRRGE--GIGYYGLAtTLAMALGPALGLFLYQHLGFAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 176 GGTISIILFTLVLqVFFYKDlnIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMnmplFVTDYLKENEQ 255
Cdd:cd17489 154 IVAAVLALLALLL-VFLVKD--PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIST----FLPLYAAERGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 256 HVGYLASLCAGLEVPFM-IILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAI-FLAVLLGIGISYF 333
Cdd:cd17489 227 SNAGLFFTVYAIALLLSrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616690429 334 QDILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFFTK 394
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-391 |
7.17e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.09 E-value: 7.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFVD 100
Cdd:cd17324 9 FAIGTTEYVIQGLLPDIA-RDFGVSVAQAGLLVSAYALGYALGALLLGPLSD--RIERRRLLLVLLLLFILGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 101 TIWLFiLLYAIFQGLFAPAMPQLYASAresINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTIS 180
Cdd:cd17324 86 SFALL-LLARALAGLAHGGFWAIAAAY---AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 181 IILFTLVLQVFFYKDLNIKHPISTQQHVEKIApnMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYL 260
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 261 ASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPDF 340
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 616690429 341 PGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIF 391
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-171 |
2.14e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 2 DMFAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKII 81
Cdd:COG2211 219 ESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK--RFGKKKA 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 82 IILALLMGALGFSIYFFVDT-----IWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDRAQFANTVLRSMFSLGFL 156
Cdd:COG2211 297 FIIGLLLAALGLLLLFFLGPgnlwlLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQA 376
|
170
....*....|....*
gi 616690429 157 FGPFIGAQLIGLKGY 171
Cdd:COG2211 377 LAGALAGLLLALFGY 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
74-349 |
6.26e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 74 HHFNRKIIIILALLMGALGFSIYFFVDTIWLFILLYAifqgLFAPAMPQLYASARESINVSSSKDRAqFANTVLRSMFSL 153
Cdd:cd17333 56 KRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMF----LAGLGAGILDTGANTFVGALFEESSA-TRLNVLHGFFGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 154 GFLFGPFIGAQLIGLK---GYAGLFGGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFIL 230
Cdd:cd17333 131 GALIGPLIATSLLTSElswSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 231 LHIGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYM 310
Cdd:cd17333 211 YVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVV 290
|
250 260 270
....*....|....*....|....*....|....*....
gi 616690429 311 MLAGQVFLAIFLAVLLGIGISYFQDILPDFPGYASTLFS 349
Cdd:cd17333 291 GLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLL 329
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-130 |
6.62e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 6.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 4 FAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIII 83
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLL 277
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 616690429 84 LALLMGALGFSIYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARES 130
Cdd:COG2814 278 IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-391 |
3.53e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 31 VPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFVDTIWLFILLYA 110
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLAD--RKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 111 ---IFQGLFAPAMPQLYASAresinvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFggTISIILFTLV 187
Cdd:cd17478 93 lagIGSAAFHPEGARLASQA--------AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLL--ILLIIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 188 LQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLhigQWMYTMNMPLFVTDYLKEN---EQHVGYLASLC 264
Cdd:cd17478 163 ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFL---RSWVLSSLTTFLPFYLVQRgysLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 265 AGLEVPFMIILGVLSSRLQTRTLLIYG----AIFGGLFYFSIGVFKNFYMMLAGqvflaIFLAVLLGIGISYFQDILPDF 340
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIASlllaAPFLLLFLLTPGIWSYILLVLAG-----FLLFASFPVTVVLAQELLPGN 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 616690429 341 PGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIF 391
Cdd:cd17478 315 VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-319 |
3.86e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 48.40 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 23 LGMGIAVTV-PYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFVDT 101
Cdd:cd17388 13 MGIGLIMPVlPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSD--RFGRRPVLLLSLAGAALDYLLMAFAPT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 102 IW-LFI--LLYAIFQGLFAPAMPqlYASaresiNVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAQLIGLKGYAG-LFGG 177
Cdd:cd17388 91 LWwLYLgrIIAGITGATGAVAAA--YIA-----DVTPPEQRAR-NFGLLGAAFGLGFIAGPALGGLLGEISPRAPfLVAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 178 TISIILFTLVLQV------------FFYKDLNikhPISTQQHVEKIAPNMFkdktLLLPFiaFILLHIGQWMYTmNMPLF 245
Cdd:cd17388 163 GLNGLNFLLGLFVlpeslpperrraFRWRRAN---PFGSLRWLTGFPGLLG----LLAVF--FLIQLIGQVPAT-TWVLF 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616690429 246 VTDYLKENEQHVGYLASLCAGLEVPFMIIL-GVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLA 319
Cdd:cd17388 233 TEDRFDWSPTMVGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLA 307
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-196 |
1.16e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILALLMGALGFSIYFFVD 100
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 101 TIWLFILLYAIFQGLFAPAMPQLYASARESInvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTIS 180
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
170
....*....|....*.
gi 616690429 181 IILFTLVLQVFFYKDL 196
Cdd:COG2271 346 LALLAALLALLLLRET 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
225-392 |
3.50e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 225 FIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGV 304
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 305 FKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPD-FPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASI 383
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
....*....
gi 616690429 384 MLGMILIFF 392
Cdd:pfam07690 162 LLAAVLLLL 170
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
21-187 |
3.52e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.30 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDThhFNRKIIIILALLMGALGFSIYFFVD 100
Cdd:cd17390 6 FLDLFGVSMILPLLSTHI-RSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDV--VGRRPVLLICLLLTALGYVLLGFST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 101 TIWLFILLyAIFQGLFAPAMP--QLYASaresiNVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAQLIGLKG---YAGLF 175
Cdd:cd17390 83 SLALLFLS-RIPLGIFKHTQSlcKAYLS-----DLVSEQERSR-VLGRFNAASSLGFILGPVVGGHLAETDGgfyYVALL 155
|
170
....*....|..
gi 616690429 176 GGTISIILFTLV 187
Cdd:cd17390 156 CSAIFILNAGLV 167
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
3-193 |
3.83e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 3.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 3 MFAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFsdTHHFNRKIII 82
Cdd:cd17329 192 GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARL--VERFRLRKIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 83 ILALLMGALGFSIYFFVDTIWLFILLYAIF---QGLFAPAMPQLyasaresINVSSSKDRAQFANTVLRSMFSLGFLFGP 159
Cdd:cd17329 270 MIGILLFAIGFAVLAFANTLAVLILAMIVLtlgEMLVFPAVQTL-------VAALAPPDKRGSYMGFYALAWGLGRAIGP 342
|
170 180 190
....*....|....*....|....*....|....
gi 616690429 160 FIGAQLIGLKGYAGLFGGTISIILFTLVLQVFFY 193
Cdd:cd17329 343 LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
30-325 |
8.12e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.52 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 30 TVPYLvlfaTKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDThhFNRKIIIILALLMGALGFSIYFFVDTIWLFIL-- 107
Cdd:cd17331 22 VLPYL----TKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDL--FGPRAALVLSFLSSALSYLLLAFASSVPMLFLsr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 108 LYAIFQGLFAPAmpQLYASAresinVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAQLIGLKGY--AGLFGGTISIIlfT 185
Cdd:cd17331 96 LPSVFMHAMQAA--QMVVTD-----LTDPGERAA-ALGRLGLSYGIGMVVGSFLGGLLTKKFGEqaAALVAAVGSLL--S 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 186 LVLQVFFYKDLNiKHPISTQQHVEKIAPNMFKDKTLL----LPFIAFILLHIGQWMYTMNM-----PLFVTDYLKENEQH 256
Cdd:cd17331 166 IVLVILLIPSNT-KSKREKEAKESASPPSVFNLKEILrllrLPGVAFLLLVKLLSGLPIGMfqsmfSLVAMDFFGLTPEE 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616690429 257 VGYLASlCAGLEVPFM--IILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVL 325
Cdd:cd17331 245 NGYLMS-YAGVLGMVVqgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVL 314
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-393 |
8.94e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 8.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 21 FLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLAS----AAISQFTVNSIIARFSdthhfnRKIIIILALLMGALGFSIY 96
Cdd:cd17474 9 LLAVLGVSIVDPILPAIA-EALGASPAQVGLLITAftlpAAVLMPVAGVLADRFG------RKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 97 FFVDTIWLFILLYAIfQGLFAPAMPQLYASAreSINVSSSKDRAQfANTVLRSMFSLGFLFGPFIGAqLIGLKGYAGLFG 176
Cdd:cd17474 82 GLSDSFALLLAGRAL-QGIGAAGLGPLALTL--IGDLFEGGERAK-AMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 177 GTISIILFTLVLqVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQH 256
Cdd:cd17474 157 LLAALIPVAFLA-ILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 257 VGYLASLCAGLEVPFMIILG-VLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAgqvfLAIFLAVLLGIGISYFQD 335
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLI----AIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616690429 336 IL-----PDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSSASIMLGMILIFFT 393
Cdd:cd17474 312 LVtelapEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-330 |
2.28e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.94 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 23 LGMGIAVT-VPYLVLFATKDLGMTTNQYGLL-----LASAAISQFTvnSIIARfsdthHFNRKIIIILALLMGALGFSIY 96
Cdd:COG2807 28 LNLRPAITsVGPLLPEIRADLGLSATQAGLLttlplLAFGLFAPLA--PRLAR-----RFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 97 FFVDTIWLFILLYAIF---QGLFAPAMPQLyasaresINVSSSKDRAqFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAG 173
Cdd:COG2807 101 SLAPSVALLLAGTALIgagIAVGNVLLPGL-------IKRWFPDRVG-LMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 174 LFGGTISIILFTLVLQVFFYKDlniKHPISTQQHVEKIAPNMFKDKTLLLpFIAFILLHIGQWmYTMN--MPLFVTDyLK 251
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRR---RPAAAAAAPAAASLRSLWRSPLAWL-LTLFFGLQSLLY-YAVVawLPPILRD-AG 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616690429 252 ENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLiygAIFGGLFYFsIGVFknfyMMLAGQVFLAIFLAVLLGIGI 330
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL---LLLLGLLGL-AGLL----GLLLAPGSLPWLWAVLLGLGQ 317
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
7-115 |
4.89e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 7 LLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILAL 86
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
90 100
....*....|....*....|....*....
gi 616690429 87 LMGALGFSIYFFVDTIWLFILLYAIFQGL 115
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
4-194 |
5.86e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.80 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 4 FAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFaTKDLGMTTNQYGLLLASAAISQ----FTVNSIIARFSDTHhfnrk 79
Cdd:cd17335 191 LLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEipffFFSSRLIQRFGHVG----- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 80 iIIILALLMGALGFSIYFFVDTIWLfILLYAIFQGLFAPAMpqlYASARESINVSSSKDRAQFANTVLRSM-FSLGFLFG 158
Cdd:cd17335 265 -LLYLGLLAYVVRWLLYSFLENPWL-VLPIELLHGLTFALV---WAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLG 339
|
170 180 190
....*....|....*....|....*....|....*.
gi 616690429 159 PFIGAQLIGLKGYAGLFGGTISIILFTLVLQVFFYK 194
Cdd:cd17335 340 SLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-393 |
6.97e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 6.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 212 APNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDyLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYG 291
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 292 AIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILP-DFPGYASTLFSNAMVIGQLGGNLLGGAMSHWV 370
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|...
gi 616690429 371 GLENVFFVSSASIMLGMILIFFT 393
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRL 184
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-305 |
7.64e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 7.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFAtKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDthHFNRKIIIILALLMGALGFSIYFFV 99
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIGLLLFGLASLLCGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFILLYAIfQGLFAPAMpqlYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTI 179
Cdd:COG0477 100 PSPELLIAARAL-QGIGAGGL---MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 180 SIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLkeneqhVGY 259
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL------LLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 616690429 260 LASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVF 305
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-188 |
1.12e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 20 MFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILALLMgALGFSIYFFV 99
Cdd:cd17330 183 YFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLA-IIGLLLLPFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 100 DTIWLFILLYAIFQGLFAPAMPQLYAsareSINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTI 179
Cdd:cd17330 262 SSVPLLVLAAAILAFGTGIVFPALSA----LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
....*....
gi 616690429 180 SIILFTLVL 188
Cdd:cd17330 338 GLLLIALFL 346
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
40-331 |
1.26e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.64 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 40 KDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHfnRKIIIILALLMGALGFSIYFFVDTIWLFILLYAIfQGLFAPA 119
Cdd:cd17504 24 REFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYG--RKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL-QGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 120 MPQLYASARESInvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLF--GGTISIILFTLVlqvffykdln 197
Cdd:cd17504 101 FPLAFALVREEF----PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFwtAAPVAVLLAALV---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 198 ikhPIstqqhvekIAPNMFKDKTLLLPFIAFILLHIGqwmyTMNMPLFVTDYLKENEQHVGYLASLCAGL-EVPFMIIL- 275
Cdd:cd17504 167 ---PL--------IDLRLLRRRNVLLANITALLAGFG----MFMVFQLLPQLLQLPTPTGFGLGITEAGLlLLPGALVMl 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690429 276 ------GVLSSRLQTRTLLIYGAIFGGLFYFSIGVFknfymmlAGQVFLAIFLAVLLGIGIS 331
Cdd:cd17504 232 iagplaGRLIARVGPRRVLLIGLVISAVGLLLLALL-------HSSLWALVVALLLIGIGLG 286
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
5-120 |
3.79e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 5 AALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFnrKIIIIL 84
Cdd:cd17321 162 VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--RLVLVA 239
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 616690429 85 ALLMGALGFSIYFFV---DTIWLFILLYAIF---QGLFAPAM 120
Cdd:cd17321 240 GLLLTAVGLLLLALLgadSSVWLLLPGLVLLglgLGLFATPL 281
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
4-188 |
4.65e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 4 FAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSdTHHFNRKIIII 83
Cdd:cd17331 200 ILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPL-TKRFGERSLLK 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 84 LALLMGALGFSIYFFVDTIWLFILLYAIFqgLFAPAMPQLYASARESINVSSSkDRAqfanTVL---RSMFSLGFLFGPF 160
Cdd:cd17331 279 LSVALLAIGYLLLAFVTTVWQLLVLLLPL--VIGGSVLYTVITSLLTKAVPPE-DTG----TALglsHALFSLVRTVSPT 351
|
170 180 190
....*....|....*....|....*....|
gi 616690429 161 IGAQLIGLKGYA--GLFGGTISIILFTLVL 188
Cdd:cd17331 352 IGGALLQAYGFPsfGLLGAAINGLLTVYLL 381
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-188 |
8.50e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 15 LFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDThhFNRKIIIILALLMGALGFS 94
Cdd:cd17471 203 LLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKR--FGKRRLLLAGFLAGVLFYL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690429 95 IYFFVDTIWLFILL-------YAIFQGLFAPAMPQLyasaresinvssSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIG 167
Cdd:cd17471 281 GLALATSLWQLIALqllnaifIGITAGLGISYFQDL------------MPGQPGLATTLYSNASRIGSLLGGLLAGVIAQ 348
|
170 180
....*....|....*....|.
gi 616690429 168 LKGYAGLFGGTISIILFTLVL 188
Cdd:cd17471 349 YFGYRAVFLVCAVLALLALVL 369
|
|
| |
