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Conserved domains on  [gi|1774892482|gb|KAE8585095|]
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hypothetical protein XENTR_v10021217 [Xenopus tropicalis]

Protein Classification

WDR46/Utp7 family protein( domain architecture ID 13237426)

WDR46/Utp7 family protein is a WD40 repeat domain-containing protein, similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 417-495 1.24e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 198101  Cd Length: 80  Bit Score: 166.25  E-value: 1.24e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482  417 PYMCLQVKGP-IHGLQFCPFEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLDP 495
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 219-368 1.39e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 219 TVNDVKWLHTHTMYAAA-QRRWLYIYDsqGVELHCIKKF----NDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAa 293
Cdd:cd00200   137 WVNSVAFSPDGTFVASSsQDGTIKLWD--LRTGKCVATLtghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG- 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774892482 294 TCV-KSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:cd00200   214 TLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 339-407 2.45e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774892482 339 HRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSC---LLPLGAGSLCHSQKGLLAAGTGDIVQVYK 407
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 417-495 1.24e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 166.25  E-value: 1.24e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482  417 PYMCLQVKGP-IHGLQFCPFEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLDP 495
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 417-494 1.37e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 166.09  E-value: 1.37e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774892482 417 PYMCLQVKG-PIHGLQFCPFEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLD 494
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 219-368 1.39e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 219 TVNDVKWLHTHTMYAAA-QRRWLYIYDsqGVELHCIKKF----NDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAa 293
Cdd:cd00200   137 WVNSVAFSPDGTFVASSsQDGTIKLWD--LRTGKCVATLtghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG- 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774892482 294 TCV-KSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:cd00200   214 TLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
270-401 5.75e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 270 LLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVD 349
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1774892482 350 KTGMYMASSGLDRKLTIFDMRTYRPLTSCLLPLGA-GSLCHSQKG-LLAAGTGD 401
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDGkTLASGSDD 351
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 339-407 2.45e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774892482 339 HRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSC---LLPLGAGSLCHSQKGLLAAGTGDIVQVYK 407
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
WD40 pfam00400
WD domain, G-beta repeat;
330-368 3.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1774892482 330 KEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 330-368 5.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1774892482  330 KEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 417-495 1.24e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 166.25  E-value: 1.24e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482  417 PYMCLQVKGP-IHGLQFCPFEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLDP 495
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 417-494 1.37e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 166.09  E-value: 1.37e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774892482 417 PYMCLQVKG-PIHGLQFCPFEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLD 494
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 219-368 1.39e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 219 TVNDVKWLHTHTMYAAA-QRRWLYIYDsqGVELHCIKKF----NDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAa 293
Cdd:cd00200   137 WVNSVAFSPDGTFVASSsQDGTIKLWD--LRTGKCVATLtghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG- 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774892482 294 TCV-KSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:cd00200   214 TLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 264-401 1.52e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 264 FLPYHFLLATCSSTGFLQYLDVSVGKeiaatCVK-----SGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLC 338
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTGK-----CVAtltghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774892482 339 HRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSCLLPLGA-GSLCHSQKG-LLAAGTGD 401
Cdd:cd00200   218 HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSvTSLAWSPDGkRLASGSAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-401 8.80e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 8.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 257 NDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCV-KSGRLNVMCQNPNNAVIhLGHHNGTVSLWSPSMKEPLVK 335
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1774892482 336 MLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSCLLPLGAGSLC--HSQKGLLAAGTGD 401
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVafSPDGTFVASSSQD 156
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-376 8.88e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 8.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 220 VNDVKWL-HTHTMYAAAQRRWLYIYDSQGVELHC-----IKKFNDVLrmeFLPYHFLLATCSSTGFLQYLDVSVGKEIaa 293
Cdd:cd00200    12 VTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRtlkghTGPVRDVA---ASADGTYLASGSSDKTIRLWDLETGECV-- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 294 TCVKSGRLNVMC--QNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRT 371
Cdd:cd00200    87 RTLTGHTSYVSSvaFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166


                  ....*
gi 1774892482 372 YRPLT 376
Cdd:cd00200   167 GKCVA 171
WD40 COG2319
WD40 repeat [General function prediction only];
270-401 5.75e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 270 LLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVD 349
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1774892482 350 KTGMYMASSGLDRKLTIFDMRTYRPLTSCLLPLGA-GSLCHSQKG-LLAAGTGD 401
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDGkTLASGSDD 351
WD40 COG2319
WD40 repeat [General function prediction only];
180-371 8.52e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 8.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 180 YRINYARNGRHLLLAGQRGHLASLEWQSKKLICEMNV-METVNDVKWLHTHTMYAAA-QRRWLYIYDSQ-GVELHCIKKF 256
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGTVRLWDLAtGELLRTLTGH 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 257 ND-VLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVK 335
Cdd:COG2319   288 SGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1774892482 336 MLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRT 371
Cdd:COG2319   368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
270-401 1.06e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 270 LLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVD 349
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1774892482 350 KTGMYMASSGLDRKLTIFDMRTYRPLTSclLPLGAG---SLCHSQKG-LLAAGTGD 401
Cdd:COG2319   214 PDGKLLASGSADGTVRLWDLATGKLLRT--LTGHSGsvrSVAFSPDGrLLASGSAD 267
WD40 COG2319
WD40 repeat [General function prediction only];
233-377 1.67e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 233 AAAQRRWLYIYDSQGVELHCIKKFNDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAV 312
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774892482 313 IHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTS 377
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157
WD40 COG2319
WD40 repeat [General function prediction only];
270-401 1.94e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 270 LLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVD 349
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1774892482 350 KTGMYMASSGLDRKLTIFDMRTYRPLTscLLPLGAG---SLCHSQKG-LLAAGTGD 401
Cdd:COG2319   256 PDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGgvnSVAFSPDGkLLASGSDD 309
WD40 COG2319
WD40 repeat [General function prediction only];
162-401 2.33e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 162 DITSASKHFNLNLNQFGPYRINYARNGRHLLLAGQRGHLASLEWQSKKLICEMNV-METVNDVKWLHTHTMYAAA-QRRW 239
Cdd:COG2319   148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGsADGT 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 240 LYIYD-SQGVELHCIKKFND-VLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGH 317
Cdd:COG2319   228 VRLWDlATGKLLRTLTGHSGsVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 318 HNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSCLLPLGA-GSLCHSQKG-LL 395
Cdd:COG2319   308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAvTSVAFSPDGrTL 387


                  ....*.
gi 1774892482 396 AAGTGD 401
Cdd:COG2319   388 ASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
257-401 2.58e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774892482 257 NDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAVIHLGHHNGTVSLWSPSMKEPLVKM 336
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774892482 337 LCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSclLPLGAG---SLCHSQKG-LLAAGTGD 401
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGavrSVAFSPDGkLLASGSAD 225
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 339-407 2.45e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774892482 339 HRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTYRPLTSC---LLPLGAGSLCHSQKGLLAAGTGDIVQVYK 407
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
WD40 pfam00400
WD domain, G-beta repeat;
330-368 3.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1774892482 330 KEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 330-368 5.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1774892482  330 KEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFD 368
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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