|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-381 |
2.07e-64 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 210.55 E-value: 2.07e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 15 GNWIGQIGLNWFVLTTYHNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCVLTYsFTAIPI 94
Cdd:cd06173 14 GDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL-LGSLSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 95 SVIIIYATLRGILSAVETPLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAV 174
Cdd:cd06173 93 WLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 175 LLCLPLHFKVTKIPEDAAR--YMPLKVIIDYFKLHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTM 252
Cdd:cd06173 173 LLLLFIRRPPPAAPGESSSllLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 253 CAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERG 331
Cdd:cd06173 253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLsPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 616686461 332 KVLSIIMMD-RGMIPLGSLLMSICADVFGIVRTFSIMGISTICITMVFYLI 381
Cdd:cd06173 333 RVFSVYNALnSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
15-394 |
1.64e-27 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 113.69 E-value: 1.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 15 GNWIGQIGLNWFVLTTYHNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCVLTYsFTAIPI 94
Cdd:pfam05977 25 GTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAG-LGLLSP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 95 SVIIIYATLRGILSAVETPLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYF--I 172
Cdd:pfam05977 104 WLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFavI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 173 AVLLCLPLHFKVTKIPED---AARYMPLKviidYFKLHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIA 249
Cdd:pfam05977 184 AALWRWKRAAPASPLPRErifGAVRAGLR----FTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGIL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 250 MTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDY 328
Cdd:pfam05977 260 LGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALaPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRW 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616686461 329 ERGKVLSI-IMMDRGMIPLGSLLMSICADVFGIvrTFSIMGISTICITMVFYLINRKLK----LKLEESNH 394
Cdd:pfam05977 340 VRGRALAVyQTVFFGGMAAGSWLWGAVAEALSV--TGALLGAAAALLAGAAAGLRFRLPegeaADLIPSNH 408
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-339 |
1.42e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.74 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 15 GNWIGQIGLNWFVLTTYHNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSsFLVTAILCVLTYSFTaipi 94
Cdd:COG2814 25 GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL-FALGSLLCALAPSLW---- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 95 sVIIIYATLRGILSAVETPLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAV 174
Cdd:COG2814 100 -LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 175 LLCLpLHFKVTKIPEDAARYMPLKVIIDYFKLhmegRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCA 254
Cdd:COG2814 179 LLLL-RLLPESRPAARARLRGSLRELLRRPRL----LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 255 IGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKV 333
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALaGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333
|
....*.
gi 616686461 334 LSIIMM 339
Cdd:COG2814 334 SGLYNS 339
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-381 |
2.55e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 49 LLLSVWAGAIADKYDKGRLLRITISSSFLVTaILCVLTYSFTaipisVIIIYATLRGILSAVETPLRQAILPDLSDKIST 128
Cdd:cd17325 45 LLFSPPAGRLSDRFGRKRLLLLGLLLLAVST-LLFAFATSYW-----QLLLARFLQGLASAAVWPAAMALIADIAPPEER 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 129 TQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLClpLHFKVTKIPEDAARYMPLKVIIDYFKLHM 208
Cdd:cd17325 119 GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLA--LLLLPEPRPPPNKRAVSAARLRSGLRLLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 209 EGRQIFITSLLIMATGFSYT---TLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFG 285
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGalePFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 286 IALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSI--IMMDRGMIpLGSLLMSICADVFGIVR 362
Cdd:cd17325 277 VALLLLPLaTSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLfnTAFSLGMV-LGPLLGGFLYDAFGFAT 355
|
330
....*....|....*....
gi 616686461 363 TFSIMGISTICITMVFYLI 381
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-339 |
1.96e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.83 E-value: 1.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 37 LGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCVltysftAIPISVIIIYATLRGILSAVETPLRQ 116
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF------ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 117 AILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAI-CYFIAVLLCLPLHFKVTKIPEDAARYM 195
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIlSLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 196 PLKVIIDYFKLHMEGRQIFITSLLIMATGFSYTTLLPVLtNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVN 275
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616686461 276 MYYLSSFLFGIALLGVVF----HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIMM 339
Cdd:pfam07690 267 RLLLALLLLILAALGLLLlsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNT 334
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-381 |
3.38e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 67.21 E-value: 3.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 45 LVPILLLSVWAGAIADKYdkGRllRITISSSFLVTAILCVLtySFTAIPISVIIIYATLRGILSAVETPLRQAILPDLSD 124
Cdd:cd17474 44 TLPAAVLMPVAGVLADRF--GR--KKVLLPGLLLFGIGGLL--CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 125 KISTTQAVSFHSFIINICRSIGPAIAGVILAV-YHAPttFLAQAICYFIAVLLCLPLHfKVTKIPEDAARYMPLKVIIDY 203
Cdd:cd17474 118 GGERAKAMGLYEAALGLGIAVGPLLGGLLAAIsWRYP--FFLLAALIPVAFLAILFLL-PEPKEKAKSSSATKLRDLKKA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 204 FKlHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKY-IGMVNMYYLSSF 282
Cdd:cd17474 195 LR-GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 283 LFGIALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSII-MMDRGMIPLGSLLMSICADVFGI 360
Cdd:cd17474 274 LYALSLLLLGFvPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYnFVRFLGQAVGPLLFGLLLEIFGL 353
|
330 340
....*....|....*....|.
gi 616686461 361 VRTFSIMGISTICITMVFYLI 381
Cdd:cd17474 354 SAPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-380 |
3.12e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.29 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 32 HNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKgrllRITISSSFLVTAILCVLtySFTAIPISVIIIYATLRGILSAVE 111
Cdd:cd06174 28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGR----RPVLLLGLLLFALGALL--FAFAPSFWLLLLGRFLLGLGSGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 112 TPLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGvILAVYHAPTTFLAQAICYFIAVLLCLPLHFKV----TKI 187
Cdd:cd06174 102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG-ILASSLGFGWRAVFLIAAALALLAAILLLLVVpdppESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 188 PEDAARYMPLKVIIDYFKLHMEGR--QIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLP 265
Cdd:cd06174 181 RAKNEEASSKSVLKLLKRVLKNPGlwLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 266 KVL-KYIGMVNMYYLSSFLFGIALLGVVFH-NIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIMM-DRG 342
Cdd:cd06174 261 LLSdRLIGRKPLLLIGLLLMALGLALLLLApSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTfGFL 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 616686461 343 MIPLGSLLMSICADVFGIVRTFSIMGISTICITMVFYL 380
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
33-306 |
4.96e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 4.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 33 NAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCvltysFTAIPISVIIIYAtLRGILSAVET 112
Cdd:cd17329 33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG-----FAHSPWLFAIALV-LTGFGGGLFE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 113 PLRQAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGViLAVYHAPTTFLAQAICYFIAVLLCLpLHFKVTKIPEDAA 192
Cdd:cd17329 107 PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLAAAVLFLLAALVLL-FLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 193 RYMPLKVIIDYFKLHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIG 272
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270
....*....|....*....|....*....|....
gi 616686461 273 MVNMYYLSSFLFGIALLGVVFHNIVIMFICITLI 306
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIV 298
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
77-309 |
5.75e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.69 E-value: 5.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 77 LVTAILCVLTY-----SFTAIPISVIIIYATLRGILSAVETPLRqAILPDLSDKIST-TQAVSFHSFIINICRSIGPAIA 150
Cdd:COG2211 89 IPLALSFVLLFtapdlSPTGKLIYALVTYLLLGLAYTLVNIPYS-ALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 151 GVILAVYHA------PTTFLAQAICYFIAVLLCLplhFKVTKIPEDAARYMPLKVIIDYFKLHMEGRQIFITSLLIMATG 224
Cdd:COG2211 168 PPLVAAFGGdaalgyRLTALIFAVLGLLAFLLTF---FGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLAL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 225 FSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVVF---HNIVIMFI 301
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgpGNLWLLLV 324
|
....*...
gi 616686461 302 CITLIGLF 309
Cdd:COG2211 325 LAALAGIG 332
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-310 |
6.44e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 60.28 E-value: 6.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 45 LVPILLLSVWAGAIADKYDKGRLLRITISSsFLVTAILCVLTYSFTaipisVIIIYATLRGILSAVETPLRQAILPDLSD 124
Cdd:cd17320 44 LLGFALGQLLYGPLSDRFGRRPVLLAGLLL-FILASLLCALASSIE-----QLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 125 KISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPlhFKVTKIPEDAARYMPLKVIIDYF 204
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL--FLPETLPEEKRKPLLSSLLRAYK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 205 KLHMEGRQIF--ITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSF 282
Cdd:cd17320 196 RVLKNRRFLGyaLALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLL 275
|
250 260
....*....|....*....|....*...
gi 616686461 283 LFGIALLGVVFHNIVIMFICITLIGLFS 310
Cdd:cd17320 276 LLLAAALVLLLAALLGGLSLWPLVAPLF 303
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
49-338 |
1.79e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 55.66 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 49 LLLSVWAGAIADKYDKGRLLRITISSSFLVTAILCVltysftAIPISVIIIYATLRGILSAVeTPLRQAILPDLSDKIST 128
Cdd:cd17330 48 FLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL------SRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEER 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 129 TQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLplhfkvtkipedaaRYMPLKviidyfklhm 208
Cdd:cd17330 121 AKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVL--------------FFLPPL---------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 209 egRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATI-VLPKVLKYIGMVNMYYLSSFLFGIA 287
Cdd:cd17330 177 --RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAIIG 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 616686461 288 LLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIM 338
Cdd:cd17330 255 LLLLPFaSSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQ 306
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-380 |
2.47e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 49 LLLSVWAGAIADKYDKGRLLRItissSFLVTAILCVLtYSFTAIPISVIIIYAtLRGILSAVETPLRQAILPDLSDKIST 128
Cdd:cd17489 45 LLARPFAGRLLDRFGRKRLLLI----GLLIFALATLL-YLLATSVALLLVLRL-IHGIGWGAFTTAAATLVADIIPPSRR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 129 TQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLHFKVTKIPEDAARYMPLKVIIDYfklhm 208
Cdd:cd17489 119 GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE----- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 209 egRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIAL 288
Cdd:cd17489 194 --KKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 289 LGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSI--IMMDRGMIpLGSLLMSICADVFGIVRTFS 365
Cdd:cd17489 272 LLLSFaGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTffIFFDLGIG-LGGLLLGLVAELFGYRAMFL 350
|
330
....*....|....*
gi 616686461 366 IMGISTIcITMVFYL 380
Cdd:cd17489 351 LAAVVVL-LALVLYI 364
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
32-375 |
6.24e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 54.93 E-value: 6.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 32 HNAVYLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRITISSSFLVTAiLCVLTYSFTAIPISVIIIYatLRGILSAVE 111
Cdd:PRK08633 44 EQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTL-LIVLAYYLGWFWLAFAVTF--LLGAQSAIY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 112 TPLRQAILPDL--SDKISTT----QAVSFHSFIinicrsIGPAIAGVILAVYHAPTTF-----LAQAICYFIAV-LLCLP 179
Cdd:PRK08633 121 SPAKYGIIPELvgKENLSRAngllEAFTIVAIL------AGTALFSFLFESVNGNTPSeilgrIAPAGLVLLAVaVLGLI 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 180 LHFKVTKIP------EDAARYMPLKVIIDYFKLHMEGRQIFITsllimATGFSYTTLLPVLTNKVFP--GKsEIFGIAMT 251
Cdd:PRK08633 195 FAYRLPKVPaaapevFDKKKYLFPKLLWRNLKLLRSDRVLWLA-----IIGLSYFWFISQLAQANFPayAK-EVLGLDNT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 252 McAIGGIIATIVLPkvlkyIGMVNMY--YLSSF----------LFGIALLGVVFH---NIVIMFICITLIGLFSQWARTT 316
Cdd:PRK08633 269 F-QVQYLLAASAIG-----IGIGSLLagRLSGRhielglvplgALGLALSLFLLPtapSLASVLVLFFLFGFSAGLFIVP 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616686461 317 NRVYFQNNVKDYERGKVL--SIIMMDRGMipLGSLLMSICADVFGI--VRTFSIMGISTICIT 375
Cdd:PRK08633 343 LNALIQFRAPEKELGKVLaaNNFLQNVGM--LLFLALTTLFSGLGLspAGLFYLIALVTLIGT 403
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-369 |
1.50e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 56 GAIADKYDKGRLLRITIsssfLVTAILCVLTYSFTAIPIsvIIIYATLRGILSAVETPLRQAILPDLSDKiSTTQAVSFH 135
Cdd:cd17478 52 GYLADRKPRRYLLPLGP----LLTGLGLSLLGFAPNYWL--LLLLVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 136 SFIINICRSIGPAIAGVILAVYHAPTTFLAQAIcyfIAVLLCLPLHFKVTKIPEDAARYMPLKVIIDYFKLHMegRQIFI 215
Cdd:cd17478 125 SVGGNLGFALGPLIAAALVALFGGLGLLILLII---PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVW--RALLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 216 TSLLIMA---TGFSYTTLLPVLTNKVFPGKSEIfGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVV 292
Cdd:cd17478 200 LLIIVFLrswVLSSLTTFLPFYLVQRGYSLVFA-GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616686461 293 FHNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYeRGKVLSIIM-MDRGMIPLGSLLMSICADVFGIVRTFSIMGI 369
Cdd:cd17478 279 LTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMgLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
19-256 |
1.56e-06 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 50.35 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 19 GQIGLNWFVLTTYHNAVYLgivnfcrlVPILLLSVWAGAIADKYDKGRLLRItISSSFLVTAILCVLTYSFTAIPISVII 98
Cdd:PRK06814 44 GALGAYNNALVTLAGAVFI--------LPFFIFSALAGQLADKYDKAKLAKI-LKFAEIGIAALAIYGFHLNSVPLLFAA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 99 IYatLRGILSAVETPLRQAILPDL--SDKISTTQA-VSFHSFIINIcrsIGPAIAGviLAVYHAPTTFLAQAIcYFIAVl 175
Cdd:PRK06814 115 LF--LMGIHSALFGPIKYSILPDHlnKDELLGANAlVEAGTFIAIL---LGTIIGG--LATISGNFVILVALL-MGIAV- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 176 LCLPLHFKVTKIPEDAA----RYMPLKVIIDYFKLHMEGRQIFITSL------LIMATGFSyttLLPVLTNKVFPGKSEI 245
Cdd:PRK06814 186 LGWLASLFIPKTGNAAPdlkiDRNIIRSTITLLKYAKADKRIWLAILgiswfwLVGAVVLS---QLPLLAKETLGGDENV 262
|
250
....*....|.
gi 616686461 246 FGIAMTMCAIG 256
Cdd:PRK06814 263 ATLFLAVFSVG 273
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
49-373 |
3.89e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 3.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 49 LLLSVWAGAIADK-YDKGRLLRITisssfLVTAILCVLTYSFTAIPISVIIIYATLRGILSAVeTPLRQAILPDLSDKIS 127
Cdd:cd17471 46 IVVSQWLGRLSDRgGDRKPLILLA-----LLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAA-FPQLFALAREYADRSS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 128 TTQAVsfhsFIINICRS-------IGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLHFKVTKIPEDAARYMPLKVI 200
Cdd:cd17471 120 GRDAT----LFNSVLRAafslawvIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 201 IdyfkLHMEGRQIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMyYLS 280
Cdd:cd17471 196 P----VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRL-LLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 281 SFLFGIAL-LGVVFHNIVIMFICI-----TLIGLFSqwarTTNRVYFQNNVKDYeRGKVLSIIM--MDRGMIpLGSLLMS 352
Cdd:cd17471 271 GFLAGVLFyLGLALATSLWQLIALqllnaIFIGITA----GLGISYFQDLMPGQ-PGLATTLYSnaSRIGSL-LGGLLAG 344
|
330 340
....*....|....*....|.
gi 616686461 353 ICADVFGIVRTFSIMGISTIC 373
Cdd:cd17471 345 VIAQYFGYRAVFLVCAVLALL 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-380 |
7.89e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 7.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 48 ILLLSVWAGAIADKYDKGRLLRItissSFLVTAILCVLTYSFTAIPisVIIIYATLRGILSAVETPLRQAILPDLSDKIS 127
Cdd:cd17473 48 IALFAPLAGWLADRFGRKRLLIA----GLLLYGIGGVAGLFLDSLY--ALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 128 TTQAVSFHSFIINICRSIGPAIAGVILAVY-HAPTTFLAQAICYFIAVLLCLP-----LHFKVTKIPEDAARYMPLKVII 201
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALAEIGwRAPFLVYLLALPVLILVLLFLPeparkSKSAASPGAATAAALPWKRVLP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 202 dyfklhmegrqIFITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSS 281
Cdd:cd17473 202 -----------IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 282 FLFGIALLGVVF-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIMMdrgMIPLGS-----LLMSICA 355
Cdd:cd17473 271 ALMALGFLLLALaSGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS---AFFLGQflsplVLGPLVN 347
|
330 340
....*....|....*....|....*
gi 616686461 356 DVFGIVRTFSIMGISTICITMVFYL 380
Cdd:cd17473 348 LTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-186 |
8.03e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 8.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 49 LLLSVWAGAIADKYdkGRLLRITISSSFLVTAILCVLTYSFTAIPISVIIIyaTLRGILSAVETPLRQAILPDLSDKIST 128
Cdd:COG2271 230 IVGSLLGGWLSDRL--GRRRKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGGAFGLLWALAAELFPKKAR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 616686461 129 TQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLHFKVTK 186
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
56-386 |
4.62e-05 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 45.35 E-value: 4.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 56 GAIADKYDKGRLLRITISSSFLVTAILCVltYSFTAIPiSVIIIY--ATLRGILSAVETPLRQAILPDLSDKISTTQAVS 133
Cdd:PRK10489 73 GVLADRYDRKKLILLARGTCGLGFIGLAL--NAFLPEP-SLLAIYllGLWDGFFGSLGVTALLAATPALVGRENLMQAGA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 134 FHSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLHfkvTKIPEDAARYMPLKVIIDYFKL----HME 209
Cdd:PRK10489 150 ITMLTVRLGSVISPALGGLLIAAGGVAWNYGLAAAGTFITLLPLLRLP---ALPPPPQPREHPLRSLLAGFRFllasPVV 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 210 GRQIFITSLLIMATGFSytTLLPVLTNKVFPGKSEIFGIAMTMCAIG--------GIIATIVLPKVLKYIGMVnmyylSS 281
Cdd:PRK10489 227 GGIALLGGLLTMASAVR--VLYPALADEVWQMGAAQIGLLYAAVPLGaalgaltsGWLAHSARPGLLMLLSTL-----GS 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 282 FLfGIALLGVVFHnIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSIIM-MDRGMIPLGSLLMSICADVFGI 360
Cdd:PRK10489 300 FL-AVGLFGLMPM-WILAVLCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTaQNVTGDAIGAALLGGLGAMMTP 377
|
330 340
....*....|....*....|....*.
gi 616686461 361 VRTFSIMGISTICITMVFYLINRKLK 386
Cdd:PRK10489 378 VASASASGFGLLIIGVLLLLVLGELR 403
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
55-386 |
1.39e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 55 AGAIADKYdkGRllRITISSSFLVTAILCVLTYSFTAIPisVIIIYATLRGILSAVETPLRQAILPDLSDKISTTQAVSF 134
Cdd:COG2271 65 AGLLADRF--GR--RRVLAIGLLLWGLATLLFGFATSFW--QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 135 HSFIINICRSIGPAIAGVILAVYHAPTTFLAQAICYFIAVLLCLPLhfkvtkipedaarymplkviidyfklhmegrqIF 214
Cdd:COG2271 139 FNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL--------------------------------LA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 215 ITSLLIMATGFSYTTLLPVLTNKVFPGKSEIFGIAMTMCAIGGIIATIVLPKVLKYIG--MVNMYYLSSFLFGIALLGVV 292
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 293 F-HNIVIMFICITLIGLFSQWARTTNRVYFQNNVKDYERGKVLSII-MMDRGMIPLGSLLMSICADVFGIVRTFSIMGIS 370
Cdd:COG2271 267 LlPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVnTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
330
....*....|....*.
gi 616686461 371 TICITMVFYLINRKLK 386
Cdd:COG2271 347 ALLAALLALLLLRETR 362
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
108-310 |
1.59e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.38 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 108 SAVETPLRqAILPDLSDKISTTQAVSFHSFIINICRSIGPAIAGVILAVYHAPTTFLAQ--AICYFIAVLLCLPLHFKVT 185
Cdd:cd17313 120 NVCQGPVR-ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNlkVPFYIGAIILLVCVLVTLF 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 186 KIPEDAARYMPLKVIIDYFKLHMEGRQIFITS-------LLIMATGFSYTTLLPVLT-------NKVFPGKSEIF----- 246
Cdd:cd17313 199 FVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKimprsllRLLLVIFFWWIAFFPFELfftdymgEEVYHGTSAASshyga 278
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 247 -----GIAMTMCAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIAL-LGVVFHNIVIMFICITLIGLFS 310
Cdd:cd17313 279 gvrmgAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMaLMALVHNVTVALVLFALGGIGW 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
36-158 |
9.18e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 9.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 36 YLGIVNFCRLVPILLLSVWAGAIADKYDKGRLLRItissSFLVTAILCVLTYSFTAIPISVIIIYATLRGILSAVETPLR 115
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII----GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 616686461 116 QAILPDLSD-------KISTTQAVSFHSFIINICRSIGPAIAGVILAVYH 158
Cdd:COG2211 341 WAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
76-311 |
1.10e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.05 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 76 FLVTAILCVLTYSFTAIPisviiiYATLRGILSavetplrqailPDLSDKISTTQAVSFHSFIINIcrsIGPAIAGVILA 155
Cdd:cd17332 102 ALITYILLDLLYTLVNIP------YTALIPELT-----------DDPEERTSLTSWRMFFATIGGL---LVTVLPPPLVA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 156 VYHAPTTFLAQAICYFIAVLLCLPL----HFKVTKIPEDAARYMPLKVIIDYFKLHMEGRQIFITSLLIMATGFSY---T 228
Cdd:cd17332 162 YFGGGNASRGYFLTALIIGIIGIILllicFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFnivN 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 229 TLLPVLTNKVFPGKSEIFGIAMTMcAIGGIIATIVLPKVLKYIGMVNMYYLSSFLFGIALLGVVF---HNIVIMFICITL 305
Cdd:cd17332 242 TVLVYYFKYVLGGRAELVLLLLLI-LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlppGNLVLILVLAVL 320
|
....*.
gi 616686461 306 IGLFSQ 311
Cdd:cd17332 321 AGIGYG 326
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
50-309 |
1.82e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 50 LLSVWAGAIADKYDKGRllRITISSSFLVTAILCVLtysFTAIPISVIIIYATLRGILSAVETPLRQAILPDLSDKISTT 129
Cdd:cd17370 49 LLRLFSGYLSDRTGKRK--PLVILGYGLSALAKPLL---ALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 130 QAVSFHSFIINICRSIGPAIAGVILAVYHAP--TTFLAQAICYFIAVLLCLplhfKVTKIPEDAARYMPLKVIIDYFKLH 207
Cdd:cd17370 124 KAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILL----FVVKEYPRPPKLRKKSKKTSLKKLP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616686461 208 MEGRQIFITSLLIMATGFSYtTLLPVLTNKVFPGKSEI---FGIAMTMCAIGGIIATIVLPKvlkyIGMVNMYYLSSFLF 284
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSF-AFLILRAQELGLSAALIpllYALFNLVYALAAYPAGRLSDR----IGRKKLLILGYLSL 274
|
250 260
....*....|....*....|....*.
gi 616686461 285 GIALLGVVF-HNIVIMFICITLIGLF 309
Cdd:cd17370 275 ALAYLGFALgSSLWLLLLGFILWGLY 300
|
|
| |
