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Conserved domains on  [gi|616544232|gb|KAD46144|]
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bone sialoprotein-binding protein, partial [Staphylococcus aureus VET0302R]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MSCRAMM_SdrD super family cl37929
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal ...
 1-175 4.18e-55

MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.


The actual alignment was detected with superfamily member NF012181:

Pssm-ID: 467951 [Multi-domain]  Cd Length: 1379  Bit Score: 186.94  E-value: 4.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232    1 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 80
Cdd:NF012181 1205 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232   81 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSATKDHQNKAKALPETGSENNGSNNATLFGGLFAV 160
Cdd:NF012181 1285 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAA 1364

                         170
                  ....*....|....*
gi 616544232  161 LGSLLLFGRRKKQNK 175
Cdd:NF012181 1365 LGSLLLFGRRKKQNK 1379
 
Name Accession Description Interval E-value
MSCRAMM_SdrD NF012181
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal ...
 1-175 4.18e-55

MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.


Pssm-ID: 467951 [Multi-domain]  Cd Length: 1379  Bit Score: 186.94  E-value: 4.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232    1 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 80
Cdd:NF012181 1205 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232   81 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSATKDHQNKAKALPETGSENNGSNNATLFGGLFAV 160
Cdd:NF012181 1285 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAA 1364

                         170
                  ....*....|....*
gi 616544232  161 LGSLLLFGRRKKQNK 175
Cdd:NF012181 1365 LGSLLLFGRRKKQNK 1379
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
130-175 1.18e-05

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 40.60  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 616544232  130 DHQNKAKALPETGSEnngSNNATLFGGLFAVLGSLLLFGRRKKQNK 175
Cdd:pfam00746   1 AKKSKKKTLPKTGEN---SNIFLTAAGLLALLGGLLLLVKRRKKEK 43
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 61-175 4.39e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.97  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232  61 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSATKD-----HQNKA 135
Cdd:NF033609 811 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNgtnasNKNEA 890

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 616544232 136 K----ALPETGSEnnGSNNATLFGGLFAVLGSLLLFgRRKKQNK 175
Cdd:NF033609 891 KdskePLPDTGSE--DEANTSLIWGLLASLGSLLLF-RRKKENK 931
pullulan_Gpos TIGR02102
pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important ...
 120-173 4.88e-03

pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. In contrast, a glycogen debranching enzyme such GlgX, homologous to this family, can release glucose at alpha,1-6 linkages from glycogen first subjected to limit degradation by phosphorylase. Characterized members of this family include a surface-located pullulanase from Streptococcus pneumoniae () and an extracellular bifunctional amylase/pullulanase with C-terminal pullulanase activity (.


Pssm-ID: 273973 [Multi-domain]  Cd Length: 1111  Bit Score: 36.76  E-value: 4.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 616544232   120 TPVKPMSATKDHQNKakaLPETGSennGSNNATLFGGLFAVLGSLLLFGRRKKQ 173
Cdd:TIGR02102 1064 GNEEKKEEQPDKGAN---LPNTGT---KNSNFILFGGLLVLLGTLGYLLKRKKQ 1111
 
Name Accession Description Interval E-value
MSCRAMM_SdrD NF012181
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal ...
 1-175 4.18e-55

MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.


Pssm-ID: 467951 [Multi-domain]  Cd Length: 1379  Bit Score: 186.94  E-value: 4.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232    1 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 80
Cdd:NF012181 1205 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232   81 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSATKDHQNKAKALPETGSENNGSNNATLFGGLFAV 160
Cdd:NF012181 1285 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAA 1364

                         170
                  ....*....|....*
gi 616544232  161 LGSLLLFGRRKKQNK 175
Cdd:NF012181 1365 LGSLLLFGRRKKQNK 1379
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
130-175 1.18e-05

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 40.60  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 616544232  130 DHQNKAKALPETGSEnngSNNATLFGGLFAVLGSLLLFGRRKKQNK 175
Cdd:pfam00746   1 AKKSKKKTLPKTGEN---SNIFLTAAGLLALLGGLLLLVKRRKKEK 43
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 61-175 4.39e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.97  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616544232  61 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSATKD-----HQNKA 135
Cdd:NF033609 811 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNgtnasNKNEA 890

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 616544232 136 K----ALPETGSEnnGSNNATLFGGLFAVLGSLLLFgRRKKQNK 175
Cdd:NF033609 891 KdskePLPDTGSE--DEANTSLIWGLLASLGSLLLF-RRKKENK 931
pullulan_Gpos TIGR02102
pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important ...
 120-173 4.88e-03

pullulanase, extracellular, Gram-positive; Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. In contrast, a glycogen debranching enzyme such GlgX, homologous to this family, can release glucose at alpha,1-6 linkages from glycogen first subjected to limit degradation by phosphorylase. Characterized members of this family include a surface-located pullulanase from Streptococcus pneumoniae () and an extracellular bifunctional amylase/pullulanase with C-terminal pullulanase activity (.


Pssm-ID: 273973 [Multi-domain]  Cd Length: 1111  Bit Score: 36.76  E-value: 4.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 616544232   120 TPVKPMSATKDHQNKakaLPETGSennGSNNATLFGGLFAVLGSLLLFGRRKKQ 173
Cdd:TIGR02102 1064 GNEEKKEEQPDKGAN---LPNTGT---KNSNFILFGGLLVLLGTLGYLLKRKKQ 1111
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 138-172 8.40e-03

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 32.83  E-value: 8.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 616544232  138 LPETGSENNgsNNATLFGGLFAVLGSLLLFGRRKK 172
Cdd:TIGR01167   2 LPKTGESGN--SLLLLLGLLLLGLGGLLLRKRKKK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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