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Conserved domains on  [gi|1756553854|gb|KAB1278773|]
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Ly6/PLAUR domain-containing protein 6 [Camelus dromedarius]

Protein Classification

acrosomal protein SP-10( domain architecture ID 11246579)

acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 46-198 2.51e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467145  Cd Length: 89  Bit Score: 156.48  E-value: 2.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  46 GFKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltf 125
Cdd:cd23625     1 GFKCFTCEKAADNYECNRWAPDIYCPRE---------------------------------------------------- 28

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756553854 126 aisiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 198
Cdd:cd23625    29 ------------TRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 89
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 46-198 2.51e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467145  Cd Length: 89  Bit Score: 156.48  E-value: 2.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  46 GFKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltf 125
Cdd:cd23625     1 GFKCFTCEKAADNYECNRWAPDIYCPRE---------------------------------------------------- 28

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756553854 126 aisiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 198
Cdd:cd23625    29 ------------TRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 89
UPAR_LY6_2 pfam16975
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ...
 40-209 8.50e-49

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.


Pssm-ID: 435685  Cd Length: 106  Bit Score: 155.58  E-value: 8.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  40 TTPYPGGFKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtw 119
Cdd:pfam16975   1 TTPYPSGFKCFTCEAADDNYCCNRWAPDWCCPRT---------------------------------------------- 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854 120 qvgltfaisiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNE 199
Cdd:pfam16975  35 ------------------TYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCSSCCEGNICNVVLPNNT 96

                         170
                  ....*....|
gi 1756553854 200 TDATFATTSP 209
Cdd:pfam16975  97 TAAVFATTSP 106
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 46-198 2.51e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467145  Cd Length: 89  Bit Score: 156.48  E-value: 2.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  46 GFKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltf 125
Cdd:cd23625     1 GFKCFTCEKAADNYECNRWAPDIYCPRE---------------------------------------------------- 28

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756553854 126 aisiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 198
Cdd:cd23625    29 ------------TRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 89
UPAR_LY6_2 pfam16975
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ...
 40-209 8.50e-49

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.


Pssm-ID: 435685  Cd Length: 106  Bit Score: 155.58  E-value: 8.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  40 TTPYPGGFKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtw 119
Cdd:pfam16975   1 TTPYPSGFKCFTCEAADDNYCCNRWAPDWCCPRT---------------------------------------------- 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854 120 qvgltfaisiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNE 199
Cdd:pfam16975  35 ------------------TYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCSSCCEGNICNVVLPNNT 96

                         170
                  ....*....|
gi 1756553854 200 TDATFATTSP 209
Cdd:pfam16975  97 TAAVFATTSP 106
TFP_LU_ECD_LYPD6_like cd23567
extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like ...
 47-196 7.94e-30

extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like family; The LYPD6-like family includes LYPD6 and LYPD6B. LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467097  Cd Length: 88  Bit Score: 106.67  E-value: 7.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  47 FKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltfa 126
Cdd:cd23567     1 ITCFTCENKTDNYECNRWAIDRPCPQG----------------------------------------------------- 27

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1756553854 127 isiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCL--STGCRDSEHEGHKVCTSCCEGNICNLPLP 196
Cdd:cd23567    28 -----------TSYCYTVHVMDSRGRSVSVTKKCATPSECTpnTVGCRDSTDTGHTVCISCCDGSYCNVEVP 88
TFP_LU_ECD_LYPD6B cd23626
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6B (LYPD6B) and ...
 47-198 1.03e-21

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6B (LYPD6B) and similar proteins; LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. LYPD6B contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467146  Cd Length: 88  Bit Score: 85.69  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756553854  47 FKCFTCEKAADNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltfa 126
Cdd:cd23626     1 FKCFTCENAPDNYNCNRWAEDKWCPQN----------------------------------------------------- 27

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1756553854 127 isiklyfllteTRYCYTQHTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRN 198
Cdd:cd23626    28 -----------TQYCLTIHHFTSHGKSKSVTKKCASREECHFVGCHHHRDSGHTECVSCCEGMICNVEVPTN 88
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 136-192 1.35e-04

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 39.39  E-value: 1.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1756553854 136 TETRYCYTQhTMEVTGNSISVTKRCVPLEDCLSTGCRDSEHEGHKVCTSCCEGNICN 192
Cdd:cd00117    26 SPETFCRKI-VGKVGGGETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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