|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
2-440 |
0e+00 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 640.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 2 RLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLF 81
Cdd:NF040895 1 KLKSIGIVVALVLIMFMAAIETSIISLALPTIKEDLNAGSSISLVFTVYFIALVIANPIVGELLSRFKIIYITILGLLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 82 TVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHW 161
Cdd:NF040895 81 IIGSLMSGLSETFTMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 162 LFYINIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNVEK 241
Cdd:NF040895 161 LFFINIPIAIIAIILVIFTFHFPEEETTSKTKFDVKGLTLFYIFIALLMFAVLNQGHLWLNIISFILAIVVFFLLFKVEK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 242 KVSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRK 321
Cdd:NF040895 241 KVKNPFLPVKEFNKSIILVFFTDFLIAMMLMGYNLYIPIYLQEHLGLSPLQSGLVIFPLSVAWLILNFNLAKIEAKLTRK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 322 VIYLSSFTLLLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIM 401
Cdd:NF040895 321 GLYIGAFTLLIVCSILILFGLKLPLLIAFALILAGLSFGTVYTKDSVIVQEETSPSNMKKMMSFYTLTKNLGSSIGSTIM 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 616193588 402 GYLYALKSGLFGANLHNILGVVSLISVGLIVVWLIFYRE 440
Cdd:NF040895 401 GYIYALQVGLFGLSIQNILALIIIILIILIILWSTLYKE 439
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
12-400 |
5.98e-38 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 140.78 E-value: 5.98e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLS 91
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 92 THFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYinipiai 171
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 172 iaiilvvwtfhfpeeetvakskfdtkgitlFYIFIGLIMFALLnqqhlylniigfvlailvalrlfnvekkvsspflpva 251
Cdd:cd17502 154 ------------------------------INLPIGGLALALL------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 252 efnRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFnlhhIEAKLSRKVIYLSSFTLL 331
Cdd:cd17502 167 ---RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSI----ISGALISKTGRYKPLIVI 239
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616193588 332 LLSSIIIAFGI-------KLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTI 400
Cdd:cd17502 240 GTILMSVGAGLlttltldTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
12-438 |
3.38e-33 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 128.85 E-value: 3.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDtVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYInipia 170
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 iiaiilvvwtfhfpeeetvakskfdtkgitlfyifigLIMFAllnqqhlylnIIGFVLAILVALRLFNvekkvsspflpv 250
Cdd:cd17503 156 -------------------------------------NLPIG----------ILALLLAPLLDLRLFK------------ 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 251 aefNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLS-RKVIYLSSFT 329
Cdd:cd17503 177 ---DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGpRLLLLAGLLL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 330 LLLLSSIIIAFGIKLPIL-IACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALK 408
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWlIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNR 333
|
410 420 430
....*....|....*....|....*....|
gi 616193588 409 SGLFGANLHNILGVVSLISVGLIVVWLIFY 438
Cdd:cd17503 334 TQFHHSRLSELLAQQVQKQALIIAFNDAFL 363
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
6-405 |
6.99e-31 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 124.03 E-value: 6.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 6 IVTVIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVG 84
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSlSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 85 SLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFY 164
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 165 inIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLFYIFIGLIMFAL--------LNQQH-LYLNIIGFVLAILVALR 235
Cdd:TIGR00711 161 --INVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLsegpergwFDSNEiLILSITGLVAIIAFVVW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 236 lfnvEKKVSSPFLPVAEF-NRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHI 314
Cdd:TIGR00711 239 ----ELTDDNPLVDLRLFkYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 315 EAKLS--RKVIYLSSFTLLLLSSIIIAFGIKLPIL-IACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKN 391
Cdd:TIGR00711 315 GDKIDprKLVTIGLILYAVGFYWRAFTFTPDTPFLaIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQ 394
|
410
....*....|....
gi 616193588 392 LGASIGSTIMGYLY 405
Cdd:TIGR00711 395 LGGSIGTALITTIL 408
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-396 |
2.70e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.91 E-value: 2.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 8 TVIALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSL 86
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPaQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 87 MSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYIN 166
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 167 IPIAIIAIILVVWTfhFPEEETVAKSKFDTKGITLFYifiglimfallnqqhlylniigfvlailvalrlfnvekkvssp 246
Cdd:COG2814 171 AVLALLALLLLLRL--LPESRPAARARLRGSLRELLR------------------------------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 247 flpvaefNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLS 326
Cdd:COG2814 206 -------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 327 SFTLLLLSSIIIAFGIKLPILIACVLILsGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASI 396
Cdd:COG2814 279 GLLLLALGLLLLALAGSLWLLLLALFLL-GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-303 |
3.08e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 109.18 E-value: 3.08e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNA-GNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGAsPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFyinipia 170
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 iiaiilvvwtfhfpeeetvakskfdtkgitLFYIFIGLIMFALLnqqhlylniigfvlailvalrlfnvekkvsspflpv 250
Cdd:cd17321 154 ------------------------------LINVPIGLVALLLA------------------------------------ 167
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 616193588 251 aefnRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVA 303
Cdd:cd17321 168 ----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-437 |
2.34e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 100.72 E-value: 2.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASpAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGIlefATWHWLFYINI 167
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL---AAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 168 PIAIIAIILVVWTFHFPEEETVAKSKFDTKgitlfyifiGLIMFALLNqqhlylniigfvlailvalrlfnvekkvsspf 247
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATK---------LRDLKKALR-------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 248 lpvaefNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHI-EAKLSRKVIYLS 326
Cdd:cd17474 197 ------GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 327 SFTLLLLSSIIIAFGIKLPILIACvLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYA 406
Cdd:cd17474 271 GLLLYALSLLLLGFVPSLALLLIA-IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
410 420 430
....*....|....*....|....*....|.
gi 616193588 407 lksglfGANLHNILGVVSLISVGLIVVWLIF 437
Cdd:cd17474 350 ------IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-435 |
6.19e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 6.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVaQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIA 170
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 IIAIILVVWtfhFPEEETVAKSKFDTKGITLFYIFIGLIMfallnqqhlylniigfvlailvalrlfnvekkvsspflpv 250
Cdd:cd17325 161 LLALVLALL---LLPEPRPPPNKRAVSAARLRSGLRLLLR---------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 251 aefNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTL 330
Cdd:cd17325 198 ---DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 331 LLLSSIIIAFGIKLPILIAcVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALkSG 410
Cdd:cd17325 275 SAVALLLLPLATSFWLLLL-LLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-FG 352
|
410 420
....*....|....*....|....*
gi 616193588 411 LFGANLhnILGVVSLISVGLIVVWL 435
Cdd:cd17325 353 FATPFL--AAAALLLLAAVLFLLLR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-282 |
2.01e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 88.33 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 4 KSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFT 82
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASsAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 83 VGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWL 162
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 163 FYINIPIAIIAIILVVW---TFHFPEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNV 239
Cdd:COG0477 171 FLINAPLGLLALVLRLRlpeSRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 616193588 240 EKKVSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYL 282
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-398 |
5.82e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.78 E-value: 5.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALP-TIKQDLNA-GNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSG 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGIsPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 90 LSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYinipi 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 170 aiiaiilvvwtfhfpeeetvakskfdtkgITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNVEKKVSspflp 249
Cdd:pfam07690 156 -----------------------------ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP----- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 250 vaefnrmITLVFITDLLTAVCLMGFNLYIPVYlQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFT 329
Cdd:pfam07690 202 -------VLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616193588 330 LLLLSSIIIAF--GIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGS 398
Cdd:pfam07690 274 LLILAALGLLLlsLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-404 |
6.49e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 84.94 E-value: 6.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNA-GNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTsAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGvMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYinipia 170
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFW------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 iiaiilvvwtfhfpeeetvakskfdtkgitlfyifiglIMFALLnqqhlylnIIGFVLAILVALRLFnvekkvsspflpv 250
Cdd:cd17504 154 --------------------------------------TAAPVA--------VLLAALVPLIDLRLL------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 251 aeFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQ----LGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLS 326
Cdd:cd17504 175 --RRRNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI 252
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616193588 327 SFTLLLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYL 404
Cdd:cd17504 253 GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
9-179 |
7.92e-18 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 84.55 E-value: 7.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASaSAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINI 167
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170
....*....|..
gi 616193588 168 PIAIIAIILVVW 179
Cdd:cd17320 161 LLGLLLLLLVLL 172
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-435 |
5.27e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 82.24 E-value: 5.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 10 IALILIMFMAAIESSIISLALPTIKQ--DLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQhfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFaTWHWLFYini 167
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFL--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 168 piaiiaiilvvwtfhfpeeetvakskfdtkgitlfyifiglimfallnqqhLYLniIGFVLAILVALRLFN-----VEKK 242
Cdd:cd17473 158 ---------------------------------------------------VYL--LALPVLILVLLFLPEparksKSAA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 243 VSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKV 322
Cdd:cd17473 185 SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 323 IYLSSFTLLLLSSIIIAFGIKLPILIACVlILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMG 402
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGA-ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLG 343
|
410 420 430
....*....|....*....|....*....|...
gi 616193588 403 YLYALKSGLFGANLhnILGVVSLISVGLIVVWL 435
Cdd:cd17473 344 PLVNLTGGLSGAFL--ILGVLALVLAIVLLLLR 374
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
17-300 |
1.07e-16 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 82.09 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 17 FMAAIESSIISLALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFS 95
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLhMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 96 MLIISRVIQGFGSGVM-----MSLSQIVPKLAFeiplrYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIA 170
Cdd:PRK10504 100 ELLLARVLQGVGGAMMvpvgrLTVMKIVPREQY-----MAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 IIAIILVVWTFhfpEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLN---IIGFVLAILVALRLF-NVEKKVSSP 246
Cdd:PRK10504 175 IIGAIATLMLM---PNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSplaIAGLVAVGVVALLLYlLHARNNNRA 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 616193588 247 FLPVAEF-NRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPL 300
Cdd:PRK10504 252 LFSLKLFrTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPM 306
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-183 |
3.02e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 73.75 E-value: 3.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 7 VTVIALILIMFMAAIESSIISLALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGS 85
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAqLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 86 LMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYI 165
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170
....*....|....*...
gi 616193588 166 NIPIAIIAIILVVWTFHF 183
Cdd:COG2271 170 LGLPGLLLALLRFWLLAL 187
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
44-164 |
5.93e-12 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 63.05 E-value: 5.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 44 SLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAF 123
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 616193588 124 EIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFY 164
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL 121
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
3-303 |
1.31e-11 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 66.29 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 3 LKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNA-GNLISLIFTAYfiALVIANPIV--GELLTRFKIIYIAIAGLT 79
Cdd:PRK14995 2 FRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGAsGNELLWIIDIY--SLVMAGMVLpmGALGDRIGFKRLLMLGGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 80 LFTVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAF-EIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFAT 158
Cdd:PRK14995 80 LFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 159 WHWLFYINIPIAIIAIILVVWTfhFPEEETVAKSKFDTKGITLFYIFIGLIMF----ALLNQQHLYLNIIGFVLAILVAL 234
Cdd:PRK14995 160 WGSVFLINVPIVLVVMGLTARY--VPRQAGRRDQPLNLGHALMLIVAILLLVYsaktALKGFLSLWVTSLTLLTGALLLG 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 235 RLFNVEKKVSSPFLPVAEFNRMITLVFITDLLTA-VCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVA 303
Cdd:PRK14995 238 LFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAmITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVA 307
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
29-179 |
9.54e-11 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 63.17 E-value: 9.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 29 ALPTIKQDLNA-GNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFG 107
Cdd:TIGR00710 27 AFPEIAADLSTpASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616193588 108 SGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVW 179
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFF 178
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-212 |
2.23e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.18 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 10 IALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMS 88
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDaQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 89 GLSTHFSMLIISRVIQGFGSGVMM-SLSQIVPKLAFEipLRYKIMGIVGSVWGISSIIGPLLGGGILEF---ATWHWLfY 164
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLDvAANPYVAALGPE--TAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLP-Y 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 616193588 165 INIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLF------YIFIGLIMFA 212
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSllknprLLLGGLAIFL 221
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
11-305 |
2.25e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 62.64 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 11 ALILIMFMAAIESSI-ISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSG 89
Cdd:cd06179 1 AALCLAYFAQLFGVTlPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 90 LSTHFSMLIISRVIQGFGSGvmmsLSQIVPKLAFEI-PLRYK--IMGIVGSVWGISSIIGPLLGGGILE--FATWHWLFY 164
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAG----TQGLGAAVASELvPNKYRglVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 165 INIPIAIIAIILVVWTFHFPEEETVAKS-------KFDTKGITLFYIFIGLIMFALL---------NQQHLYLNIIGFVL 228
Cdd:cd06179 157 INAIFNALALILLFFFYHPPPRPQLHGSstrqklkRLDWVGLFLLIAGLVLFLLGLSwggnpypwsSAHVIAPLVIGGVL 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616193588 229 AILVALRLFNVEKKvssPFLPVAEF--NRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWI 305
Cdd:cd06179 237 LIAFGLYEWKGTKD---GLLPPRLLfrGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTL 312
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-432 |
7.44e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.52 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSAsQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIA 170
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 IIAIILVVWTFHFPEEETVAKSKfdtkgitlfyifiglimfallnqqhlylniigfvlailvalrLFNVEKKVSSPFLPV 250
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAK------------------------------------------NEEASSKSVLKLLKR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 251 AEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTL 330
Cdd:cd06174 199 VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 331 LLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALKSG 410
Cdd:cd06174 279 LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
410 420
....*....|....*....|..
gi 616193588 411 LFGANLhnILGVVSLISVGLIV 432
Cdd:cd06174 359 LTGAFL--VLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-406 |
2.11e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSvAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYini 167
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 168 piaiiaiilvvwtfhfpeeetvakskfdtkgitlfyiFIGLIMfallnqqhlylniigFVLAILVALRLFNVEKKVSSPF 247
Cdd:cd17324 158 -------------------------------------AIAVLA---------------LLAALLLWRLLPSLPPKKPGSL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 248 LPVAEFNRMIT--LVFITDLLTAVCLMGFNL---YIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKV 322
Cdd:cd17324 186 GLLSSLLLLLRnpRLRLAYLITFLLFGGFFAlytYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 323 IYLSSFTLLLLSSIIIAFGIKLPILIAcVLILSGLSFGYIYTKDSVIVQeETSPIQMKKMMSFYGLTKNLGASIGSTIMG 402
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLLLLV-GLVLWGLGFFAAHSALQTRVL-RLAPEARGLASSLYLAAYNLGGALGAALGG 343
|
....
gi 616193588 403 YLYA 406
Cdd:cd17324 344 LVLD 347
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
9-164 |
6.14e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 57.59 E-value: 6.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVG---ELLTRfKIIYIAiaGLTLFTVG 84
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSeEVANLGVSLFVLGFGLGPLIWAplsELYGR-RPVYLV--SLFIFVIF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 85 SLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFY 164
Cdd:cd17323 78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW 157
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-164 |
3.82e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.88 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 8 TVIALILIMFMAA-IESSIISLALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRF---KIIYIAIAGLTLFT 82
Cdd:cd17319 3 RIIPLLFLAYVINyLDRVNISVAAPTIMKDLGLSPTqYGLIASAFFLGYALFQVPGGWLLDRFgarKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 83 VgslMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWL 162
Cdd:cd17319 83 A---LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
..
gi 616193588 163 FY 164
Cdd:cd17319 160 FI 161
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
26-296 |
1.08e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 53.88 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 26 ISLALPTIKQDLN-AGNLISLIFTAYFIALVIANPIVGELLTRF---KIIYIAIAGLTLFTvgsLMSGLSTHFSMLIISR 101
Cdd:TIGR00893 13 LSFAAPMLQEDLGlSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFgarKTLAVFIVIWGVFT---GLQAFAGAYVSLYILR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 102 VIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFyinipiaiiaiilvvwtf 181
Cdd:TIGR00893 90 VLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAF------------------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 182 hfpeeetvakskFDTKGITlfyIFIGLIMFALL--NQQHLYLNIIGFVLAILVALRLFNVEKKVSSPFLPV---AEFNRM 256
Cdd:TIGR00893 152 ------------IIEGVLG---IIWGVLWLKFIpdPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQikeLLKDRR 216
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 616193588 257 ITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLV 296
Cdd:TIGR00893 217 VWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFM 256
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-164 |
1.09e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.90 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 1 MRLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLT 79
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVqLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 80 LFTVGSLMSGLSTHFSMLIISRVIQGFGSGVMMS-----LSQIVPKlafeiPLRYKIMGIVGSVWGISSIIGPLLGGGIL 154
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPnlnalVSEYAPK-----RFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
|
170
....*....|
gi 616193588 155 EFATWHWLFY 164
Cdd:TIGR00895 166 PVFGWRSLFY 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-163 |
2.22e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 2 RLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTL 80
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSAtQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 81 FTVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAF--EIPLrykIMGIVGSVWGISSIIGPLLGGGILEFAT 158
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFpdRVGL---MTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
....*
gi 616193588 159 WHWLF 163
Cdd:COG2807 170 WRGAL 174
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
29-286 |
6.71e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 51.59 E-value: 6.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 29 ALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFGS 108
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 109 GVMMSLSQIVPKLafeIPLRYKIMG--IVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVWTFHFPEE 186
Cdd:pfam06609 146 GPAGASPLFIGEL---MSNKTKFLGllIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHPPSF 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 187 ETVAKSKFDTKG-------ITLFYIFIGLIMFAL-------LNQQHLYLNIIGFV---LAILVALRLFNVEKKVSSPFLP 249
Cdd:pfam06609 223 AQLHGKKARKRDelakldwIGIFLVIAGTSLFLLgvswggkPNNPWNSAKIIGLIssgAGSLVIFALYEVFGKPEQPIIP 302
|
250 260 270
....*....|....*....|....*....|....*..
gi 616193588 250 VAEFNRmiTLVFITDLLTAVCLMGFNLYIPVYLQEQL 286
Cdd:pfam06609 303 PALFKD--TRGFVCILIISSIMGAMHLCLTIIYPQQV 337
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
10-163 |
1.46e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 50.21 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 10 IALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMS 88
Cdd:PRK15403 19 MALILYDFAAYLTTDLIQPGIINVVRDFNADvSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAAT 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616193588 89 GLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLF 163
Cdd:PRK15403 99 LFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLF 173
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-193 |
1.48e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 7 VTVIALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGS 85
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAaQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 86 LMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYI 165
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180
....*....|....*....|....*...
gi 616193588 166 NIPIAIIAIILVVWTFHFPEEETVAKSK 193
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-179 |
1.54e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKqdLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMS 88
Cdd:cd17329 206 LLASFLISLIYFQLESTLPVYVVEIL--GLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 89 GLSTHFSMLIISRVIQGFGSGVMMSLSQ-IVPKLAfEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINI 167
Cdd:cd17329 284 AFANTLAVLILAMIVLTLGEMLVFPAVQtLVAALA-PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILA 362
|
170
....*....|..
gi 616193588 168 PIAIIAIILVVW 179
Cdd:cd17329 363 ALGLIAAALLLG 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-404 |
1.78e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.86 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTaLIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGgilefatwhwlfyinipia 170
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 171 iiaiilvvwtfhfpeeetvaksKFDTKGITLFYIFIGLIMFALlnqqhlylniigfvlaILVALRLFNVEKKVSSPFLPV 250
Cdd:cd17477 142 ----------------------LVGTAGALPFLIAAVLLLLAL----------------VPLLLTRRAAPEIEEAESISL 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 251 AEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQeQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTL 330
Cdd:cd17477 184 RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALL 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616193588 331 LLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYL 404
Cdd:cd17477 263 GALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-177 |
3.95e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEaVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIA 170
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
....*..
gi 616193588 171 IIAIILV 177
Cdd:cd17489 161 LLALLLV 167
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
9-182 |
5.65e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 48.03 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIIslALPTIKQDLNA-GNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17476 2 TISGAQLLNQAGLGSVIV--ILPIIGDSFGTsPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKI-MGIVGSVWGISSIIGPLLGGGILEFATWHWLFYIN 166
Cdd:cd17476 80 AGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
|
170
....*....|....*.
gi 616193588 167 IPIAIIAIILVVWTFH 182
Cdd:cd17476 160 AILAAIVAVAAIFWTS 175
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
10-163 |
7.78e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 48.01 E-value: 7.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 10 IALILIMFMAAIESSIISLALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMS 88
Cdd:PRK15402 16 LCLVLFEFATYIANDMIQPGMLAVVEDFNAGaEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAI 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616193588 89 GLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLF 163
Cdd:PRK15402 96 LLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMF 170
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
12-160 |
8.05e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.98 E-value: 8.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAI---ESSIISLALPTIKQDLN--AGNLISLIfTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSL 86
Cdd:PRK11652 10 LFMLVLLVAVgqmAQTIYVPAIADMARDLNvrEGAVQAVM-AAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616193588 87 MSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPK-LAFEIPLRYK----IMGIVgsvwgISSIIGPLLGGGILEFATWH 160
Cdd:PRK11652 89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRdLYEGTQLRHAnsllNMGIL-----VSPLLAPLIGGLLTTLFGWR 162
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-435 |
1.14e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 17 FMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFK-----IIYIAIAGLTLFTVGSLMSGL 90
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSAlLVGLVLAAFFLPFLLFSPFAGVLADRFDrrrllILADLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 91 STHFSMLIISRVIQGFGSGVMMSLSQ-IVPKLAFEIPLRyKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPI 169
Cdd:cd06173 89 SLSLWLLLVLAFLLGIASAFFGPARQaLLPELVPKEQLV-RANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 170 AIIAIiLVVWTFHFPEEETVAKSKFDTKGITLFYIFIglimfallnqqhlylniigfvlailvalrlfnvekkvsspflp 249
Cdd:cd06173 168 FLLSA-LLLLFIRRPPPAAPGESSSLLLRDLREGLRY------------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 250 vAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFT 329
Cdd:cd06173 204 -LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGAL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 330 LLLLSSIIIAFGIKLPILIACVLILsGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLyalkS 409
Cdd:cd06173 283 LLGLALLVLGLSPSLWLLLAALFLL-GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL----A 357
|
410 420
....*....|....*....|....*.
gi 616193588 410 GLFGANLHNILGVVSLISVGLIVVWL 435
Cdd:cd06173 358 DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-151 |
3.54e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 3.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 12 LILIMFMAAIESSIISLALPTIKQDLN----AGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNklgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSG----VMMSLSQIVPKLAfeiplRYKIMGIVGSVWGISSIIGPLLGG 151
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGnvsvAQAYIADITDEEE-----RAKAFGIISAAFGLGFILGPALGG 143
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-164 |
4.16e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 6 IVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNL--ISLIFTAYFIALVIANPIVGELLTRF--KIIYIAIAGLTLF 81
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLaqAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 82 TVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHW 161
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
...
gi 616193588 162 LFY 164
Cdd:COG2271 339 AFL 341
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-179 |
4.87e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 45.29 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 29 ALPTIKQDLN-AGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFG 107
Cdd:PRK11102 13 ALPVIAADFGvSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616193588 108 SGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVW 179
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFF 164
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
29-164 |
1.00e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 44.24 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 29 ALPTIKQDLNAGNL-ISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFG 107
Cdd:PRK10473 25 GLPRIAADLNASEAqLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIG 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 616193588 108 SGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFY 164
Cdd:PRK10473 105 AGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-181 |
1.47e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 14 LIMFMAAIESSIISLALPTIKQDLNAGNlISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTH 93
Cdd:cd17489 201 LILFLASIAYGAISTFLPLYAAERGISN-AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 94 FSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIA 173
Cdd:cd17489 280 PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLA 359
|
....*...
gi 616193588 174 IILVVWTF 181
Cdd:cd17489 360 LVLYIFLL 367
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-163 |
1.55e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 3 LKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLF 81
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAaGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 82 TVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHW 161
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
..
gi 616193588 162 LF 163
Cdd:cd06173 365 VF 366
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
9-107 |
2.10e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.38 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIA-LVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIIsYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100
....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFG 107
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIG 100
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
8-118 |
2.35e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 43.16 E-value: 2.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 8 TVIALILIMFMAAIESSIISLALPTIKQDLN-----AGNLISliftAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFT 82
Cdd:PRK10091 4 VILSLALGTFGLGMAEFGIMGVLTELAHDVGisipaAGHMIS----YYALGVVVGAPIIALFSSRYSLKHILLFLVALCV 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 616193588 83 VGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIV 118
Cdd:PRK10091 80 IGNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIV 115
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-193 |
3.15e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 29 ALPTIKQDLNAG-NLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFG 107
Cdd:PRK11043 28 AFKAIQADLQTSaSAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 108 ---SGVmmSLSQIVPKlafeiplRYK----------IMGIVgsvwGISSIIGPLLGGGILEFATWHWLFyinIPIAIIAI 174
Cdd:PRK11043 108 vcsAAV--IWQALVID-------RYPaqkanrvfatIMPLV----ALSPALAPLLGAWLLNHFGWQAIF---ATLFAITL 171
|
170
....*....|....*....
gi 616193588 175 ILVVWTFHFPEEETVAKSK 193
Cdd:PRK11043 172 LLILPTLRLKPSKKARKQS 190
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
9-164 |
3.52e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAGN-LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLM 87
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPaQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 88 SGLSTHFSMLIISRVIQGFGSGVMMS-----LSQIVPKlafeiPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWL 162
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPnaitlVSEYAPA-----RRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSV 155
|
..
gi 616193588 163 FY 164
Cdd:cd17365 156 FL 157
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
42-164 |
7.17e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 41.87 E-value: 7.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 42 LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLST---HFSMLIISRVIQGFGSGVmmsLSQIV 118
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGG---ASVLA 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 616193588 119 PKLAFEIPlRYKIMGIVGSVWGISSIIGPLLGGGI-LEFAT------WHWLFY 164
Cdd:pfam00083 124 PMYISEIA-PKKLRGALGSLYQLAITFGILLAYIFgLGLNKtsnsdgWRIPLG 175
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-164 |
8.97e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.43 E-value: 8.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 9 VIALILIMFMAAIESSIISLALPTIKQDLNAGN---LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGS 85
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLsllQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 86 LMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFAT----WHW 161
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
...
gi 616193588 162 LFY 164
Cdd:cd17316 161 LFL 163
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
6-159 |
1.25e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 6 IVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGS 85
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616193588 86 LMSGLSTHFSMLIISR-VIQGFGSGVM-MSLSQIVPKLAFEiPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATW 159
Cdd:cd17355 83 VLLALATSLWQLYLLWgLLGGGGAGTLaAVAFATVAAWWFE-RRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
73-197 |
5.28e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 73 IAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFG--SGVMMSLsqivpkLAFEIP--LRYKIMGIVGSVWGISSIIGPL 148
Cdd:cd17472 64 VILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGaiSSVVMAL------LADLTReeNRTKAMALIGASIGIAFAISMV 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 616193588 149 LGGGILEFATWHWLFYINIPIAIIAIILVVWTFHFPEEETVAKSKFDTK 197
Cdd:cd17472 138 LGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKK 186
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
42-155 |
6.35e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 6.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616193588 42 LISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLIISRVIQGFGSGVMMSLSQIVPKL 121
Cdd:cd17390 32 VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDL 111
|
90 100 110
....*....|....*....|....*....|....
gi 616193588 122 AFEiPLRYKIMGIVGSVWGISSIIGPLLGGGILE 155
Cdd:cd17390 112 VSE-QERSRVLGRFNAASSLGFILGPVVGGHLAE 144
|
|
| |
