|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-452 |
4.07e-42 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 153.10 E-value: 4.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 16 IMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLII 95
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 96 SDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIA 175
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 176 FIAILLLkgtpekvsqhshrhpfdykgmsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhevpf 255
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 256 idfsvlrnRPFIGAFLNNFVLNSGL-GVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLII 334
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALgGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 335 GPLFPVIGITIISMTSlqPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALST 414
Cdd:cd17321 240 GLLLTAVGLLLLALLG--ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 616188443 415 TVFSMLQLNYAPSV---------------AATITFIVSIVLMILGSLSAYMII 452
Cdd:cd17321 318 ALLTAGLSANLGDSgvaallsaaaaafaaGFHLAFLVAAALALLAALLALLLP 370
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
58-418 |
1.03e-26 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 112.09 E-value: 1.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 58 ATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAI 137
Cdd:TIGR00711 49 ANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAM 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 138 SYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL-LKGTPEKVSQHSHrhPFDYKGMSIFAVMIGSFTLL 216
Cdd:TIGR00711 129 AIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAASE--NFDFLGLLLLSVGLGSLLYG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 217 LTQGFEQGWFSIFSFICLSIIIITTLIFIII-ERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGL-GVTVVFFIYAQTHL 294
Cdd:TIGR00711 207 LSEGPERGWFDSNEILILSITGLVAIIAFVVwELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLyGSFYLLPLYLQQVL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 295 GLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTsLQPSQYIIAVVIGFVICAIGNGLV 374
Cdd:TIGR00711 287 GYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFT-FTPDTPFLAIALPQFIRGFGMGCF 365
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 616188443 375 ATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFS 418
Cdd:TIGR00711 366 FMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
58-452 |
2.59e-25 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 106.89 E-value: 2.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 58 ATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAI 137
Cdd:cd17503 43 ALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 138 SYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLlkgtpekvsqhshrhpfdykgmsifavmigsftlll 217
Cdd:cd17503 123 GLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL------------------------------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 218 tqgfeqgwfsifsficlsiiiittlifiiierrheVPFIDFSVLRNRPFIGAFLNNFVLNSGL-GVTVVFFIYAQTHLGL 296
Cdd:cd17503 167 -----------------------------------APLLDLRLFKDRNFTLGLLLSFLLGLGLfGAMFLLPLYLQNVLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 297 SAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGplFPVIGITIISMTSLQPSQYIIAVVIGFVICAIGNGLVAT 376
Cdd:cd17503 212 SAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG--LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFM 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616188443 377 PGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFIVSIVLMILGSLSAYMII 452
Cdd:cd17503 290 PLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALIIAFNDAFLVS 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-407 |
1.16e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.51 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 3 NTQSSPRSNIIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMG 82
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 83 LIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNF 162
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 163 GWQTNFIISIVIAFIAILLL-KGTPEKVSQHSHRHPFDYKgmsifavmigsftllltqgfeqgwfsifsficlsiiiitt 241
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLlRLLPESRPAARARLRGSLR---------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 242 lifiiierrhevpfidfSVLRNRPFIGAFLNNFVLNSGLGVTVVFF-IYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGE 320
Cdd:COG2814 202 -----------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLpLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 321 KATLRFGGKLMLIIGplfpvIGITIISMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKM 400
Cdd:COG2814 265 RLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
|
....*..
gi 616188443 401 SGTLGGA 407
Cdd:COG2814 340 AFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
35-445 |
7.08e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.88 E-value: 7.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 35 PLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAA 114
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 115 ILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL-LKGTPEKVSQHS 193
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLaLLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 194 HRHPFDYKGMSIFavmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhevpfidFSVLRNRPFIGAFLNN 273
Cdd:cd17325 180 KRAVSAARLRSGL---------------------------------------------------RLLLRDRRLLALFLAI 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 274 FVLNSGLGVTVVFF-IYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGplfpvIGITIISMTSLQ 352
Cdd:cd17325 209 FVLAFAFGALEPFLpLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG-----LLLSAVALLLLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 353 PSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLnYAPSVAATI 432
Cdd:cd17325 284 LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF-ATPFLAAAA 362
|
410
....*....|...
gi 616188443 433 TFIVSIVLMILGS 445
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-288 |
1.07e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 83.32 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 4 TQSSPRSNIIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGL 83
Cdd:COG0477 7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 84 IISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFG 163
Cdd:COG0477 87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 164 WQTNFIISIVIAFIAILLLKGTPEKVSQHSHRHPFDYKGMSIFAVMIGSFTLLLTQGFEQGWFSIFSFICLSIIIITTLI 243
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 616188443 244 FIIIERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGLGVTVVFFI 288
Cdd:COG0477 247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-451 |
1.86e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 83.78 E-value: 1.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 41 YQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILlPST 120
Cdd:cd17504 26 FGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 121 VGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLlkgtpekvsqhshrhpfdy 200
Cdd:cd17504 105 FALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 201 kgmsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrheVPFIDFSVLRNRPFIGAFLNNFVLNSGL 280
Cdd:cd17504 166 ----------------------------------------------------VPLIDLRLLRRRNVLLANITALLAGFGM 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 281 GVTVVFFIY-----AQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQpsq 355
Cdd:cd17504 194 FMVFQLLPQllqlpTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSS--- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 356 yIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAAT---- 431
Cdd:cd17504 271 -LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTegay 349
|
410 420
....*....|....*....|.
gi 616188443 432 -ITFIVSIVLMILGSLSAYMI 451
Cdd:cd17504 350 vLAFLIGAALALAALLLSLLI 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
35-443 |
1.18e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 81.47 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 35 PLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAA 114
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 115 ILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL-LKGTPEKVSQHs 193
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLvLLFLPETLPEE- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 194 hrhpfdyKGMSIFAVMIGSFtllltqgfeqgwfsifsficlsiiiittlifiiierrhevpfidFSVLRNRPFIGaflnn 273
Cdd:cd17320 182 -------KRKPLLSSLLRAY--------------------------------------------KRVLKNRRFLG----- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 274 FVLNSGLGVTVVF-------FIYaQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITII 346
Cdd:cd17320 206 YALALGLSFAGLFaylaaapFIY-IEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 347 SMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKvGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAp 426
Cdd:cd17320 285 LLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGLLPNGTALPMG- 362
|
410
....*....|....*..
gi 616188443 427 sVAATITFIVSIVLMIL 443
Cdd:cd17320 363 -LLILVLGLLALLLLIL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-409 |
1.87e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.15 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFaqsFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:pfam07690 1 LFLAAFLAALGRSLL---GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIIS 171
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 172 IVIAFIAILLLKGTPEKVSQHSHRHpfdykgmsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiIERRH 251
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKP--------------------------------------------------AEEAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 252 EVPFIDFSVLRNRPFIGAFLNNFVLNSGLGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLM 331
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616188443 332 LIIGplFPVIGITIISMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFG 409
Cdd:pfam07690 268 LLLA--LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-444 |
3.43e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.95 E-value: 3.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 16 IMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLII 95
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 96 SDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIA 175
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 176 FIAILLL------KGTPEKVSQHSHRHPFDYKGMSIFAVMIGSFTLLLTQGfeqgwfSIFSFICLsiiiittlifiiier 249
Cdd:cd17489 161 LLALLLVflvkdpPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG------AISTFLPL--------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 250 rhevpfidfsvlrnrpfigaflnnfvlnsglgvtvvffiYAQTHLglsAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGK 329
Cdd:cd17489 220 ---------------------------------------YAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPK 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 330 LMLIIGPLFPVIGITIISMTslqpsQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFG 409
Cdd:cd17489 258 TVIIPGLLLLALGLLLLSFA-----GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLG 332
|
410 420 430
....*....|....*....|....*....|....*
gi 616188443 410 IALSTTVFSMLQLNYAPSVAATITFIVSIVLMILG 444
Cdd:cd17489 333 GLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-457 |
2.80e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 73.75 E-value: 2.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIIS 171
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 172 IVIAFIAILLlkgtpekvsqhshrhpfdykgmsifavmigsftllltqgfeqgwfsifSFICLsiiiittlifiiierrh 251
Cdd:COG2271 171 GLPGLLLALL------------------------------------------------RFWLL----------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 252 evpfidfsvlrnrpFIGAFLNNFVLNsglGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFG--GK 329
Cdd:COG2271 186 --------------ALAYFLVYFALY---GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRK 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 330 LMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFvicaiGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFG 409
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPSPALAIALLFLAGF-----GLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 616188443 410 IALSTTVFSMLQLNYApsvaatitFIVSIVLMILGSLSAYMIIPKTVK 457
Cdd:COG2271 324 PLLVGYLLDATGYQAA--------FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
35-443 |
6.86e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.99 E-value: 6.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 35 PLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAA 114
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 115 ILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATnFGWQTNFIISIVIAFIAILLLKGTPEKVSQHSH 194
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 195 RHPFDYKGMSIFAvmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhevpfidfsvLRNRPFIGAFLNNF 274
Cdd:cd17474 182 SSSATKLRDLKKA-----------------------------------------------------LRGRGLLTFLVSAF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 275 VLNSGLGVTVVFF-IYAQTHLGLSAAQSGLV-TLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQ 352
Cdd:cd17474 209 LYFFLYFAFLTYLpFLLELLYGISPIIIGLLfAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 353 PSQYIIAVVIGfvicaIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATI 432
Cdd:cd17474 289 ALLLIAIVLFG-----LGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAI 363
|
410
....*....|.
gi 616188443 433 TFIVSIVLMIL 443
Cdd:cd17474 364 ALAAAVLLALL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-443 |
2.05e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.45 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 6 SSPRSNIIIAIMLSALTYWLFAqSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLII 85
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWY-LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 86 SMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQ 165
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 166 TNFII----SIVIAFIAILLLKGTPEKVSQHSHRHPFDYKGM-SIFAVMIGSFTLLLTQGfeqgwfsifsficlsiiiit 240
Cdd:COG2223 160 NAFLIlgilLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAlRDPRFWLLSLLYFGTFG-------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 241 tlifiiierrhevpfidfsvlrnrpfigaflnnfvlnSGLGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGE 320
Cdd:COG2223 220 -------------------------------------SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 321 KATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFVICAIGNGlvATPGLTIAIFsmPNEKVGLATGLYKM 400
Cdd:COG2223 263 WLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG--AVFALVPDIF--PTKNAGAVYGLVGA 338
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 616188443 401 SGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFIVSIVLMIL 443
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
33-439 |
8.67e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.50 E-value: 8.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 33 IGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLS 112
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 113 AAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLLKGTPEKVSQH 192
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 193 SHRHPFDYKGMsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhevpfidFSVLRNRPFIGAFLN 272
Cdd:cd17324 181 KPGSLGLLSSL------------------------------------------------------LLLLRNPRLRLAYLI 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 273 NFVLNSGlgvTVVFFIYAQTHL----GLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLfpvigITIISM 348
Cdd:cd17324 207 TFLLFGG---FFALYTYLAPFLtdvpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL-----LAAALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 349 TSLQPSQYIIAVVIGFVICAIGNGLVAtPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSV 428
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLWGLGFFAAH-SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
410
....*....|.
gi 616188443 429 AATITFIVSIV 439
Cdd:cd17324 358 GAALLLLALLL 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
58-440 |
3.54e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.12 E-value: 3.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 58 ATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAI 137
Cdd:cd17502 42 TSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 138 SYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLLKgtpekvsqhshrhpfdykgmSIFAVMIGSFtlll 217
Cdd:cd17502 122 GYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALLR--------------------TILLSSIFGF---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 218 tqgfeqgwfsifsficlsiiiittlifiiierrhevpfidfsvlrnrpFIGAFLnnfvlnsgLGVTVVFFIYAQTHLGLS 297
Cdd:cd17502 178 ------------------------------------------------LFGGAL--------FGLIYYLPLYFQLVLGDS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 298 AAQSGLVTLPYAIVAVAMIRLGEKATLRFGG-KLMLIIGPLFPVIGItiISMTSLQPSQYIIAVVIGFVICAIGNGLVAT 376
Cdd:cd17502 202 ATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILMSVGA--GLLTTLTLDTSKWLLIGYLILLGLGLGIGFQ 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616188443 377 PGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALsTTVFsmlqlnYAPSVAATITFIVSIVL 440
Cdd:cd17502 280 QPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI-TDVF------LVALALAALAFLLSLFL 336
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
44-409 |
3.12e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 61.58 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 44 SPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGV 123
Cdd:TIGR00893 27 SAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPGIILI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 124 LNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFI-AILLLKGTPEKvsqhshrhPFDYKG 202
Cdd:TIGR00893 107 VASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIwGVLWLKFIPDP--------PQKAKW 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 203 MSIFAVMIGSFTLLLTQgfeqgwfsifsficlsiiiittlifIIIERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGLGV 282
Cdd:TIGR00893 179 LTEEEKYIVVGGLLAEQ-------------------------QGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 283 TVVFF-IYAQTHLGLSAAQSGLVTLPYAIVA-VAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIA- 359
Cdd:TIGR00893 234 FLTWFpTYLVQERGLSILEAGFMASLPGIVGfIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPy 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 616188443 360 VVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFG 409
Cdd:TIGR00893 314 AALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVG 363
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
39-188 |
4.24e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.00 E-value: 4.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 39 QTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLR-MTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILL 117
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616188443 118 PSTVgVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLLKGTPEK 188
Cdd:cd17490 104 SFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEE 173
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
35-198 |
1.06e-08 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 56.95 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 35 PLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAA 114
Cdd:PRK10473 27 PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 115 ILLPSTVGVLNNQFkgDHLRRAISYLMISTVGGI--GLAGVIGGLIATNFGWQTNF----IISIVIAFIAILLLKGTPEK 188
Cdd:PRK10473 107 CCYVVAFAILRDTL--DDRRRAKVLSLLNGITCIipVLAPVLGHLIMLKFPWQSLFytmaAMGILVLLLSLFILKETRPA 184
|
170
....*....|
gi 616188443 189 VSQHSHRHPF 198
Cdd:PRK10473 185 RAPAASSKPR 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-443 |
8.61e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 8.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFAQSFinigPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:cd06173 4 LWLAQLLSALGDWIFTVAL----PWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDIT-----ALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQT 166
Cdd:cd06173 80 VLALLALLgslslWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 167 NFIISIVIAFIAILLLKGTPEKVSQHSHRHPFdykgmsifavmigsftlLLTQGFEQGWFSIFSficlsiiiittlifii 246
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSS-----------------LLLRDLREGLRYLRR---------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 247 ierrhevpfidfSVLRNRPFIGAFLNNFVLNsglGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRF 326
Cdd:cd06173 207 ------------SPLLRLLLLALALFALLGG---ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 327 GGKLMLIIGPLFPVIGITIISMTSlqpsqYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGG 406
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSP-----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAM 346
|
410 420 430
....*....|....*....|....*....|....*..
gi 616188443 407 AFGIALSTTVFSMLQLNYAPSVAATITFIVSIVLMIL 443
Cdd:cd06173 347 PLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
29-198 |
4.45e-07 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 51.81 E-value: 4.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 29 SFINIG-PL------VGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDIT-- 99
Cdd:PRK05122 27 SYLTIGlPLavlpgyVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGLLaa 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 100 ------ALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIV 173
Cdd:PRK05122 107 wpvlslLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIML 186
|
170 180
....*....|....*....|....*
gi 616188443 174 IAFIAILLLKGTPEKVSQHSHRHPF 198
Cdd:PRK05122 187 LALLGLLLARPRPAVPPVKGERLPF 211
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
41-182 |
5.58e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.42 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 41 YQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPST 120
Cdd:cd17323 29 FHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIG 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616188443 121 VGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLL 182
Cdd:cd17323 109 AGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
20-418 |
5.85e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 51.86 E-value: 5.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 20 ALTYWLFAQSFINIGPLVGQTY-----QTSPAVLNLSISLTsFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLI 94
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFivadlGPSSNSTWISTAWS-LAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 95 ISDITALLIIGRILQGLSAAILLPSTVG---VLNNQFKGdhlrRAISYLMISTVGGIGLAGVIGGLIATNF--GWQTNFI 169
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAAVaseLVPNKYRG----LVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 170 ISIVIAFIAILLLKGT---PEKVSQHSHRHP-----FDYKGMSIFAVMIGSFTLLLTQGFEQGWFS---IFSFICLSIII 238
Cdd:cd06179 157 INAIFNALALILLFFFyhpPPRPQLHGSSTRqklkrLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSsahVIAPLVIGGVL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 239 ITTLIFIIIERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGLGVTVVFF-IYAQTHLGLSAAQSGLVTLPYAIVA-VAMI 316
Cdd:cd06179 237 LIAFGLYEWKGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWpQQISLLFTTDPLKAGLYQLPFGLGTlFGAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 317 RLGEKATLRFGGKLMLIIGplFPVIGITIISMTSLQPSQYIIAVVIGFVIcAIGNGLVATPGLTIAIFSMPNEKVGLATG 396
Cdd:cd06179 317 LAGLLLTKIKHIKWQLVAG--FVLFTAFLALLALITPDNKALAIAFSVLA-GIGIGGPLVLAIVIVQLSVPPEDIGTASG 393
|
410 420
....*....|....*....|..
gi 616188443 397 LYKMSGTLGGAFGIALSTTVFS 418
Cdd:cd06179 394 LLGSARALGGAVGTAIFTSILS 415
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-180 |
2.03e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.57 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 14 IAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLL 93
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 94 IISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGdHLRRAISYLMISTVGGIG--LAGVIGGLIATNFGWQ-TNFII 170
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPP-GPRKNIVFSLFGATAPLGfaLGGVFGGLFAQLAWWPwIFWFL 159
|
170
....*....|
gi 616188443 171 SIVIAFIAIL 180
Cdd:cd17476 160 AILAAIVAVA 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
259-442 |
4.53e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 259 SVLRNRPFIGAFLNNFVLNSGLGVTVVFFIY-AQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPL 337
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 338 FPVIGitIISMTSLQPSQyIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKV-------GLATGLYKMSGTLGGAFGI 410
Cdd:COG2211 303 LAALG--LLLLFFLGPGN-LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAG 379
|
170 180 190
....*....|....*....|....*....|..
gi 616188443 411 ALSTTVFSMlqLNYAPSVAATITFIVSIVLMI 442
Cdd:COG2211 380 ALAGLLLAL--FGYVAGAAQSPSALTGIRLLF 409
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-440 |
4.69e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.58 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 16 IMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLII 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 96 SDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATN--FGWQTNFIISIV 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 174 IAFIAILLLKGTPEKVSQHSHRHPFDYKGMSIFAVMigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhev 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 254 pfidFSVLRNRPFIGAFLNNFVLNSGLGVTVVFF-IYAQTHLGLSAAQSGLVTLPYAIV-AVAMIRLGEKATLRFGGKLM 331
Cdd:cd06174 197 ----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLpLFLLDLGGLSVAVAGLLLSLFGLAgALGSLLLGLLSDRLIGRKPL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 332 LIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFvicaiGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIA 411
Cdd:cd06174 273 LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF-----GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347
|
410 420
....*....|....*....|....*....
gi 616188443 412 LSTTVFSMLQLNYAPSVAATITFIVSIVL 440
Cdd:cd06174 348 LAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
67-412 |
5.70e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 48.57 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 67 GDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKgDHLRRAISYLMISTVG 146
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFT-EEKQRNMALGVWAAVG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 147 GIGLA--GVIGGLIATNFGWQTNFIISIVIAFIAILLL-------KGTPEKVSQHSHrhpfdykgmsifAVMIGSFTLLL 217
Cdd:PRK14995 141 SGGAAfgPLVGGILLEHFYWGSVFLINVPIVLVVMGLTaryvprqAGRRDQPLNLGH------------ALMLIVAILLL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 218 T-------QGFEQGWFSIFSFIclsIIIITTLIFIIIERRHEVPFIDFSVLRNRpfigAFLNNFVLNSGLGVTVVFF--I 288
Cdd:PRK14995 209 VysaktalKGFLSLWVTSLTLL---TGALLLGLFIRTQLAASRPMIDMRLFTHR----IILSGVVMAMTAMITLVGFelL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 289 YAQTH---LGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFV 365
Cdd:PRK14995 282 MAQELqfvHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALL 361
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 616188443 366 ICAIGNGLVATpglTIAIFS-MPNEKVGLATGLYKMSGTLGGAFGIAL 412
Cdd:PRK14995 362 GFSAASALLAS---TSAIMAaAPPEKAAAAGAIETMAYELGAGLGIAI 406
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
52-219 |
6.90e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 6.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 52 ISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGD 131
Cdd:cd17473 41 LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 132 HLRRAISYL-MISTVGGIGLAGVIGGLiaTNFGWQTNFII---SIVIAFIAILLLKGTPEKVSQHSHRHPFDYKGMSIFA 207
Cdd:cd17473 121 ERAKMLGLQsAAMSLGGVVFLLLGGAL--AEIGWRAPFLVyllALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR 198
|
170
....*....|..
gi 616188443 208 VMIGSFTLLLTQ 219
Cdd:cd17473 199 VLPIYFLAFLAM 210
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-182 |
6.99e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 6.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 44 SPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAI---LLPST 120
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqesIERAA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616188443 121 VGVLNNQFKgdhlrRAISYLMISTVGGIG--LAGVIGGLIATNFGWQTNFIISIVIAFIAILLL 182
Cdd:cd17370 312 VADLVPAEL-----RGTAYGLFNTVVGIGwlLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
35-181 |
9.02e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 47.76 E-value: 9.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 35 PLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAA 114
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 616188443 115 ILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL 181
Cdd:TIGR00710 109 AGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL 175
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
254-418 |
2.33e-05 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 46.53 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 254 PFIDFSVLRNRPFIGAFLNNFVLNSGLGVTVVFFI-YAQTHLGLSAAQSGLVTLPYAIV-AVAMIRLG--EKATLRFggK 329
Cdd:cd17322 275 PFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYtVLQVAVGESITSATRITNLYSFVsTVAGIFVGflIRKTRRY--K 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 330 LMLIIGPLFPVIGITIIsMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFG 409
Cdd:cd17322 353 VLVIIGVPLYIVGMGLL-IRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVG 431
|
....*....
gi 616188443 410 IALSTTVFS 418
Cdd:cd17322 432 AAISGAIWT 440
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
60-198 |
2.84e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.05 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 60 GIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAIllpstVGVL-----NNQFKGDHLR 134
Cdd:PRK11652 57 GLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGV-----GGVMartlpRDLYEGTQLR 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616188443 135 RAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVI-AFIAILLLKGTPEKVSQHSHRHPF 198
Cdd:PRK11652 132 HANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLgAGVTFSMARWMPETRPADARRTRV 196
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-183 |
3.26e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.02 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 44 SPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGV 123
Cdd:cd17319 36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKA 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616188443 124 LNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFII----SIVIAFIAILLLK 183
Cdd:cd17319 116 LAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIegllGLLLAVLWWFYLR 179
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-187 |
4.24e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 4 TQSSPRSNIIIAIMLSALTYW-----LFAQSFIniGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRM 78
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLmdgydLAAMGFA--APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 79 TYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPStVGVLNNQFKGDHLR-RAISYLMISTVGGIGLAGVIGGL 157
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPN-LNALVSEYAPKRFRgTAVGLMFCGYPIGAAVGGFLAGW 163
|
170 180 190
....*....|....*....|....*....|.
gi 616188443 158 IATNFGWQTNFIISIVI-AFIAILLLKGTPE 187
Cdd:TIGR00895 164 LIPVFGWRSLFYVGGIApLLLLLLLMRFLPE 194
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
262-458 |
1.68e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 262 RNRPFIGAFLNNFVLNSGLGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGplfpvI 341
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG-----L 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 342 GITIISMTSLQPSQYIIAVVIGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQ 421
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190
....*....|....*....|....*....|....*..
gi 616188443 422 LNYApsvaatitFIVSIVLMILGSLSAYMIIPKTVKS 458
Cdd:COG2814 163 WRWV--------FLVNAVLALLALLLLLRLLPESRPA 191
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-181 |
2.29e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFAQSFINigpLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:COG0738 215 GGLAIFLYVGAEGAIGDWLPL---YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIgGLIATNFGWQTNFIIS 171
Cdd:COG0738 292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLI-GFLADAFGLRAAFLVP 370
|
170
....*....|
gi 616188443 172 IVIAFIAILL 181
Cdd:COG0738 371 LVCYLLILLL 380
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
62-182 |
2.87e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 62 FMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILlpSTVGVLNNQ-FKGDHLRRAISYL 140
Cdd:cd17471 251 IMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGIT--AGLGISYFQdLMPGQPGLATTLY 328
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 616188443 141 MISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLL 182
Cdd:cd17471 329 SNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-185 |
4.63e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.19 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 33 IGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLS 112
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616188443 113 AAILLPsTVGVLNNQFKGDHLRRAISYLMISTVG-GIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLLKGT 185
Cdd:cd17365 101 LGAAMP-NAITLVSEYAPARRRSLAVTLMFCGYPlGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT 173
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
52-181 |
4.84e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 42.21 E-value: 4.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 52 ISLTSFATG--IFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAIllPSTV--GVLNNQ 127
Cdd:PRK11102 30 MTLSAYILGfaIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA--ASVVinALMRDM 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 616188443 128 FKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL 181
Cdd:PRK11102 108 FPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL 161
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
291-413 |
5.44e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.17 E-value: 5.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 291 QTHLGLSAAQSGLVT----LPYAIVAVAMIRLGEkatlRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFVI 366
Cdd:COG2807 45 RADLGLSATQAGLLTtlplLAFGLFAPLAPRLAR----RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 616188443 367 cAIGNglVATPGLTIAIFSmpnEKVGLATGLYKMSGTLGGAFGIALS 413
Cdd:COG2807 121 -AVGN--VLLPGLIKRWFP---DRVGLMTGLYTAAMGLGAALAAGLT 161
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
280-443 |
7.19e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.85 E-value: 7.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 280 LGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIA 359
Cdd:cd17341 222 VGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 360 VVIGFVICAIGNGLV--ATPGLTIAIFSmpnEKVGLATGLYKMSGTLGGAFgiaLSTTVFSMLQLNYAPSVAATITFIVS 437
Cdd:cd17341 302 FLALFVALGLGAGAGngSVFRMVPFIFR---RELGAVTGLVGAIGGLGGFF---LPLLFGSSALMTGSGVGAFSLFGVLA 375
|
....*.
gi 616188443 438 IVLMIL 443
Cdd:cd17341 376 VACTLL 381
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-444 |
7.33e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.78 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFkGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIIS 171
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 172 IVIAFIAILLLkgtpekVSQHSHRHPfdykgmsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiIERRH 251
Cdd:COG2807 178 ALLALLALLLW------LPLLRRRPA-------------------------------------------------AAAAA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 252 EVPFIDFSVLRNRPF--IGAFlnnFVLNSGLGVTVVFFI--YAQTHlGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFG 327
Cdd:COG2807 203 PAAASLRSLWRSPLAwlLTLF---FGLQSLLYYAVVAWLppILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 328 G-KLMLIIGPLFPVIGITIISMTSLQpsqyiiAVVIGFVICAIGNGLVATPGLTIAIFSMPN-EKVGLATGLYKMSGTLG 405
Cdd:COG2807 279 DrRPLLLLLGLLGLAGLLGLLLAPGS------LPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLL 352
|
410 420 430
....*....|....*....|....*....|....*....
gi 616188443 406 GAFGIALSTTVFSMLQlNYAPSVAATItfIVSIVLMILG 444
Cdd:COG2807 353 AALGPLLVGALHDATG-SWTAALLLLA--ALAVLMLVAG 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-151 |
7.57e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 9 RSNIIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMF 88
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616188443 89 ASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLA 151
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
37-197 |
8.43e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 41.59 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 37 VGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDIT--------ALLIIGRIL 108
Cdd:PRK12382 42 VHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYLLAAILpvsapfkfALLVVGRLI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 109 QGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAiLLLKGTPEK 188
Cdd:PRK12382 122 LGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAALALTTMVLPLLA-WAFNGTVRK 200
|
....*....
gi 616188443 189 VSQHSHRHP 197
Cdd:PRK12382 201 VPAHAGERP 209
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-188 |
1.40e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.62 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 11 NIIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYM--GLIISMF 88
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLaiGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 89 ASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNF 168
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|...
gi 616188443 169 IISI---VIAFIAILLLKGTPEK 188
Cdd:COG2271 341 LLLAalaLLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
8-186 |
1.57e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 8 PRSNIIIAIMLSALTYWLFAQSFINIGPLVGQ---TYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLI 84
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPAlkdAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 85 ISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFG- 163
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSl 161
|
170 180
....*....|....*....|....
gi 616188443 164 -WQTNFIISIVIAFIAILLLKGTP 186
Cdd:COG0738 162 sWHLPYLILAVLLLLLALLFLRSK 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
282-443 |
1.65e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 282 VTVVFFIYAQTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGplfpvIGITIISMTSLQPSQYIIAVV 361
Cdd:pfam07690 15 LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG-----LLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 362 IGFVICAIGNGLVATPGLTIAIFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFIVSIVLM 441
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
..
gi 616188443 442 IL 443
Cdd:pfam07690 170 LP 171
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
57-191 |
1.70e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.74 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 57 FATGIFM-----VAAGDIADKIGqlRMTYMGLIISMFASLLLIISDI----------TALLIIGRILQGLSAAILLPSTV 121
Cdd:cd17367 46 FAVGFLMrpiggWLFGRLADRIG--RRAALTLSVSLMAAGSLVIAVTptyatigiwaPIILLLARLLQGLSVGGEYGTSA 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616188443 122 GVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIgGLIATNF---------GWQTNFIISIVIAFIAILLLKGTPEKVSQ 191
Cdd:cd17367 124 TYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGV-LLVLQHTlgedqmaawGWRIPFLLGGVLAVVVLWLRRGLEETESF 201
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
278-443 |
3.24e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.53 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 278 SGLGVTVVFfiyAQTHLGLSAAQSGLV-TLPYAIVAVAMIRLGEkATLRFGGKLMLIIGPLFpvIGITIISMTSLQPsqy 356
Cdd:cd17475 13 QGIPALAPF---LQEDLHLSLAQVGLLlSALNLGVAVSMLPAGW-LLDRFGERRVLAVGLLL--MGAAALLMALVGS--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 357 IIAVVIGFVICAIGNGlVATPGLTIAIFS-MPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFI 435
Cdd:cd17475 84 YPVLLVLLFLVGAGYG-SVQPGGGRAIMRwFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
....*...
gi 616188443 436 VSIVLMIL 443
Cdd:cd17475 163 AAVLFWLF 170
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
54-177 |
3.28e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 54 LTSFATG--IFMVAAGDIADKIGQLRMTYMGLIISMFASLL--LIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFK 129
Cdd:cd17380 40 LSSFFWGyaLTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVP 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 616188443 130 GDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFI 177
Cdd:cd17380 120 VSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLL 167
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
21-191 |
3.58e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 21 LTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITA 100
Cdd:TIGR00881 5 AAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 101 LLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMIS-TVGGIGLAGVIGGLIATNFGWQTNFI----ISIVIA 175
Cdd:TIGR00881 85 VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCShNVGGGLLPPLVLFGIAELYSWHWVFIvpgiIAIIVS 164
|
170
....*....|....*.
gi 616188443 176 FIAILLLKGTPEKVSQ 191
Cdd:TIGR00881 165 LICFLLLRDSPQSCGL 180
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-185 |
3.86e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 16 IMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGD-----IADKIGQLRMTYMGLIISMFAS 90
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGAllfgyLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 91 LLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLI----ATNFGWQT 166
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRI 160
|
170
....*....|....*....
gi 616188443 167 NFIISIVIAFIAILLLKGT 185
Cdd:cd17316 161 LFLIGALPALLALLLRRRT 179
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
294-413 |
4.14e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.10 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 294 LGLSAAQSGLVT----LPYAIVAVAMIRLGEkatlRFGGKLMLIIGPLFPVIGITIISMTSLqPSQYIIAVVIGFVIcAI 369
Cdd:cd17339 29 LGLSASQAGLLTtlplLCFAVFSPLAPRLAR----RFGLERTLLLALLLLAAGILLRSLGGI-ALLFLGTALAGAGI-AV 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 616188443 370 GNglVATPGLTIAIFSmpnEKVGLATGLYKMSGTLGGAFGIALS 413
Cdd:cd17339 103 GN--VLLPSLIKRDFP---RRVGLMTGLYTTSMNLGAALASGLS 141
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
50-187 |
6.24e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 50 LSISLTSFATGIFMVAAgdIADKIGQLRMTYMGLIISMFASLLLIISDITA---LLIIGRILQGLSAAILLpSTVGVLNN 126
Cdd:cd17357 55 VSIFFIGGAIGSFISAF--LANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIACGLST-GFVPMYLQ 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616188443 127 QFKGDHLRRAISYLM-ISTVGGIGLAGVIG--GLIATNFGWQTNFIISIVIAFIAILLLKGTPE 187
Cdd:cd17357 132 EISPSELRGALGSLTqIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPE 195
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-182 |
6.63e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 12 IIIAIMLSALTYWLFAQSFINIGPLVGQTYQTSPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASL 91
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 92 LLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIIS 171
Cdd:cd17312 84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP 163
|
170
....*....|.
gi 616188443 172 IVIAFIAILLL 182
Cdd:cd17312 164 GIVGLVVAIIL 174
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
50-180 |
7.53e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 7.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 50 LSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISmfASLLLIISDITAL--LIIGRILQGLSAAILLPSTVGVLNNQ 127
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLAS--ALLYIPQAFVQTPwqLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 616188443 128 FKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAIL 180
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
44-443 |
8.32e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 44 SPAVLNLSISLTSFATGIFMVAAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGlSAAIllpSTVGV 123
Cdd:cd17472 30 TPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAI---SSVVM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 124 --LNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLL---KGTPEKVSQHSHRHPF 198
Cdd:cd17472 106 alLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILlffVPDPPKIVQISEKEKK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 199 DYKgmsifavmigsftllltqgfeqgwfsifsficlsiiiittlifiiierrhevpfidfSVLRNRPFIGAFLNNFVLNS 278
Cdd:cd17472 186 KLK---------------------------------------------------------KLLKNKRLLRLDFSIFILHF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 279 GLGVTVVFFIYAQTHLGLSAAQSGLVTLPYAIVA-VAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYI 357
Cdd:cd17472 209 VLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGfILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLI 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 358 IAVVIGFVICAIGNGLVATpglTIAIFSMPNEKvGLATGLYKMSGTLGGAFGIALSTTVFSMLQLNYAPSVAATITFIVS 437
Cdd:cd17472 289 IGLIIFFIGFNLLEALLPS---LVSKIAPKEYR-GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWL 364
|
....*.
gi 616188443 438 IVLMIL 443
Cdd:cd17472 365 LVSFLL 370
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
39-203 |
8.32e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.33 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 39 QTYQTSPAVLnlSISLTSFATGiFMVAA---GDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGL---S 112
Cdd:PRK11043 34 ADLQTSASAV--SASLSLFLAG-FALGQllwGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgvcS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 113 AAILLPSTVgvlNNQFKGDHLRRAISYLMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILL-LKGTPEKVSQ 191
Cdd:PRK11043 111 AAVIWQALV---IDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPtLRLKPSKKAR 187
|
170
....*....|..
gi 616188443 192 HSHRHPFDYKGM 203
Cdd:PRK11043 188 KQSQDALTFKQL 199
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
65-365 |
8.65e-03 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 38.56 E-value: 8.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 65 AAGDIADKIGQLRMTYMGLIISMFASLLLIISDITALLIIGRILQGLSAAILLPSTVGVLNNQFKGDHLRRAISYLMIST 144
Cdd:PRK10504 64 ASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 145 VGGIGLAGVIGGLIATNFGWQTNFIISIVIAFI-AILLLKGTPEKVSQHSHrhpFDYKGMSIFAVMIGSFTLLLTQGFEQ 223
Cdd:PRK10504 144 QVGPLLGPALGGLLVEYASWHWIFLINIPVGIIgAIATLMLMPNYTMQTRR---FDLSGFLLLAVGMATLTLALDGSKGL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 224 GWFSIFSFICLSIIIITTLIFIIIERRHEVPFIDFSVLRNRPFIGAFLNNFVLNSGLG----VTVVFFiyaQTHLGLSAA 299
Cdd:PRK10504 221 GLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGmlpfMTPVFL---QIGLGFSPF 297
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616188443 300 QSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTSLQPSQYIIAVVIGFV 365
Cdd:PRK10504 298 HAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQ 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
291-458 |
8.96e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 291 QTHLGLSAAQSGLVTLPYAIVAVAMIRLGEKATLRFGGKLMLIIGPLFPVIGITIISMTslqPSQYIIAVVIGFVicAIG 370
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVALA--GIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 371 NGLVATPGLTIAiFSMPNEKVGLATGLYKMSGTLGGAFGIALSTTVFSmLQLNYAPSVAATITFIVSIVLMILGSLSAYM 450
Cdd:cd17478 98 SAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVA-LFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
....*...
gi 616188443 451 IIPKTVKS 458
Cdd:cd17478 176 EAKKAAAK 183
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-182 |
1.00e-02 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 37.99 E-value: 1.00e-02
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616188443 47 VLNLSISLTSFATGIF-------MVAAGDIADKIGQLRMTYMGlIISMFASLLLIIS---------DITALLIIG----- 105
Cdd:cd17345 261 VKGFSKAQAMWAFSLFewaaipgTLLAGWLSDKLFKGRRAPTG-IIFMILVIVALIVywlapnvlvDLIALIALGfliyg 339
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616188443 106 -RILQGLSAAILLPSTVGVLNNQFKGdhlrraisylMISTVGGIGLAGVIGGLIATNFGWQTNFIISIVIAFIAILLL 182
Cdd:cd17345 340 pVMLIGLQALELVPKKAAGTAAGLTG----------LFGYLGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFL 407
|
|
| |
