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Conserved domains on  [gi|1739889105|gb|KAA1660235|]
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efflux transporter outer membrane subunit [Klebsiella pneumoniae]

Protein Classification

outer membrane factor lipoprotein domain-containing protein( domain architecture ID 1000499)

outer membrane factor (OMF) lipoprotein domain-containing protein belonging to the NodT family functions as an efflux transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
outer_NodT super family cl36990
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
48-449 3.60e-95

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


The actual alignment was detected with superfamily member TIGR01845:

Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 294.70  E-value: 3.60e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  48 WWRNFHDSTLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTQSAATGL---PIHSTLYKGG 124
Cdd:TIGR01845  50 WWTAFGDPQLNALIEEALADNPDLQVAEARLRAARANLRAARADFFPSLGLSASATRQKSSEDASGTtsgGSLSNTSTLT 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 125 LTASYDVDIWGANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETG 204
Cdd:TIGR01845 130 LDVSYELDLFGKVRRAVESALAQLEAAEADSQAARLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAG 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 205 YTSRLELMQADSELRSTRAQIPPLQHQIAQQENALSVLLGDNPG---AVKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQA 281
Cdd:TIGR01845 210 VAAASDVRQAEAAVASAEAELPSLDVQIAQARNALAALLGKGPSrglAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAA 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 282 ERQLVAADATLASSQAQLLPSINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSY 361
Cdd:TIGR01845 290 ERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQY 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 362 EKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLA 441
Cdd:TIGR01845 370 RQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSD 449

                  ....*...
gi 1739889105 442 QIDLYRAL 449
Cdd:TIGR01845 450 SVALYKAL 457
 
Name Accession Description Interval E-value
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
48-449 3.60e-95

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 294.70  E-value: 3.60e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  48 WWRNFHDSTLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTQSAATGL---PIHSTLYKGG 124
Cdd:TIGR01845  50 WWTAFGDPQLNALIEEALADNPDLQVAEARLRAARANLRAARADFFPSLGLSASATRQKSSEDASGTtsgGSLSNTSTLT 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 125 LTASYDVDIWGANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETG 204
Cdd:TIGR01845 130 LDVSYELDLFGKVRRAVESALAQLEAAEADSQAARLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAG 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 205 YTSRLELMQADSELRSTRAQIPPLQHQIAQQENALSVLLGDNPG---AVKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQA 281
Cdd:TIGR01845 210 VAAASDVRQAEAAVASAEAELPSLDVQIAQARNALAALLGKGPSrglAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAA 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 282 ERQLVAADATLASSQAQLLPSINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSY 361
Cdd:TIGR01845 290 ERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQY 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 362 EKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLA 441
Cdd:TIGR01845 370 RQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSD 449

                  ....*...
gi 1739889105 442 QIDLYRAL 449
Cdd:TIGR01845 450 SVALYKAL 457
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
56-449 7.07e-68

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 221.06  E-value: 7.07e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  56 TLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSldasltgtrartqsaatglpihstlykggltasYDVDIWG 135
Cdd:COG1538     1 TLDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS---------------------------------QELDLGG 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 136 ANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQAD 215
Cdd:COG1538    48 KRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAE 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 216 SELRSTRAQIPPLQHQIAQQENALSVLLGDNPGA---VKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQAERQLVAADATL 292
Cdd:COG1538   128 AQLAQARAQLAQAEAQLAQARNALALLLGLPPPApldLPDPLPPLPPLPPSLPGLPSEALERRPDLRAAEAQLEAAEAEI 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 293 ASSQAQLLPSINLTATGSLQDRTlpDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEV 372
Cdd:COG1538   208 GVARAAFLPSLSLSASYGYSSSD--DLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEV 285
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1739889105 373 NDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:COG1538   286 EDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRAL 362
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
2-449 2.03e-57

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 196.25  E-value: 2.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105   2 IRPVALAIVLALVGCQSADVQRAQPTLTILAAWRADVGPASPVEGVW----WRNFH-DSTLNQYVDQALRYNSDVLIARE 76
Cdd:PRK09837    4 CKLLPFSVALALTGCVSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYqntgWRTFFvDNQVKTLISEALVNNRDLRMATL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  77 RVNEYQARAYAADSSLFPSLDASLTGT-RARTQSAATGlpihSTLYKGGLTASYDVDIWGANRSAANAAGASLEAQKAAA 155
Cdd:PRK09837   84 KVQEARAQYRLTDADRYPQLNGEGSGSwSGNLKGDTAT----TREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 156 AAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQADSELRSTRAQIPPLQHQIAQQ 235
Cdd:PRK09837  160 RAVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 236 ENALSVLLGDNPGAV--KRGEFAQLTPLRLPSQLPSTLLNRRPDIAQAERQLVAADATLASSQAQLLPSINLTATGSLQD 313
Cdd:PRK09837  240 NNALQLLLGSYGKLPqaQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 314 RTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEVNDSLDAISRYGEQLTELQEQE 393
Cdd:PRK09837  320 SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1739889105 394 TVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:PRK09837  400 ASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTAL 455
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
269-449 1.89e-16

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 77.18  E-value: 1.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 269 STLLNRRPDIAQAERQLVAADATLASSQAQLLPSINLTATGSLQ-DRTLPDLLDNPLRLWSLGGSIlaPLLNRQALNAQV 347
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNsNNSESGGDDPGTGEVGLGLSQ--PLFDGGKRRARV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 348 DVSMAQRNQALYSYEKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFST 427
Cdd:pfam02321  79 KAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEA 158
                         170       180
                  ....*....|....*....|..
gi 1739889105 428 QLSVVQVKNNLLLAQIDLYRAL 449
Cdd:pfam02321 159 RLELLNAEADLELALAQLEQLL 180
 
Name Accession Description Interval E-value
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
48-449 3.60e-95

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 294.70  E-value: 3.60e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  48 WWRNFHDSTLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTQSAATGL---PIHSTLYKGG 124
Cdd:TIGR01845  50 WWTAFGDPQLNALIEEALADNPDLQVAEARLRAARANLRAARADFFPSLGLSASATRQKSSEDASGTtsgGSLSNTSTLT 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 125 LTASYDVDIWGANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETG 204
Cdd:TIGR01845 130 LDVSYELDLFGKVRRAVESALAQLEAAEADSQAARLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAG 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 205 YTSRLELMQADSELRSTRAQIPPLQHQIAQQENALSVLLGDNPG---AVKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQA 281
Cdd:TIGR01845 210 VAAASDVRQAEAAVASAEAELPSLDVQIAQARNALAALLGKGPSrglAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAA 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 282 ERQLVAADATLASSQAQLLPSINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSY 361
Cdd:TIGR01845 290 ERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQY 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 362 EKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLA 441
Cdd:TIGR01845 370 RQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSD 449

                  ....*...
gi 1739889105 442 QIDLYRAL 449
Cdd:TIGR01845 450 SVALYKAL 457
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
56-449 7.07e-68

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 221.06  E-value: 7.07e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  56 TLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSldasltgtrartqsaatglpihstlykggltasYDVDIWG 135
Cdd:COG1538     1 TLDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS---------------------------------QELDLGG 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 136 ANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQAD 215
Cdd:COG1538    48 KRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAE 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 216 SELRSTRAQIPPLQHQIAQQENALSVLLGDNPGA---VKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQAERQLVAADATL 292
Cdd:COG1538   128 AQLAQARAQLAQAEAQLAQARNALALLLGLPPPApldLPDPLPPLPPLPPSLPGLPSEALERRPDLRAAEAQLEAAEAEI 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 293 ASSQAQLLPSINLTATGSLQDRTlpDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEV 372
Cdd:COG1538   208 GVARAAFLPSLSLSASYGYSSSD--DLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEV 285
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1739889105 373 NDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:COG1538   286 EDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRAL 362
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
2-449 2.03e-57

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 196.25  E-value: 2.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105   2 IRPVALAIVLALVGCQSADVQRAQPTLTILAAWRADVGPASPVEGVW----WRNFH-DSTLNQYVDQALRYNSDVLIARE 76
Cdd:PRK09837    4 CKLLPFSVALALTGCVSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYqntgWRTFFvDNQVKTLISEALVNNRDLRMATL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  77 RVNEYQARAYAADSSLFPSLDASLTGT-RARTQSAATGlpihSTLYKGGLTASYDVDIWGANRSAANAAGASLEAQKAAA 155
Cdd:PRK09837   84 KVQEARAQYRLTDADRYPQLNGEGSGSwSGNLKGDTAT----TREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 156 AAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQADSELRSTRAQIPPLQHQIAQQ 235
Cdd:PRK09837  160 RAVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 236 ENALSVLLGDNPGAV--KRGEFAQLTPLRLPSQLPSTLLNRRPDIAQAERQLVAADATLASSQAQLLPSINLTATGSLQD 313
Cdd:PRK09837  240 NNALQLLLGSYGKLPqaQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 314 RTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEVNDSLDAISRYGEQLTELQEQE 393
Cdd:PRK09837  320 SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1739889105 394 TVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:PRK09837  400 ASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTAL 455
PRK11459 PRK11459
multidrug resistance outer membrane protein MdtQ; Provisional
5-449 8.60e-32

multidrug resistance outer membrane protein MdtQ; Provisional


Pssm-ID: 183143 [Multi-domain]  Cd Length: 478  Bit Score: 126.98  E-value: 8.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105   5 VALAIVLALVGCQSADVQRAQPTLTILAAWRADVGPASPVEG----VWWRNFHDSTLNQYVDQALRYNSDVLIARERVNE 80
Cdd:PRK11459   11 ACLPLLIMLAGCAPMHETRQALSQQTPAAHVDTALPTALKNGwpdsQWWKAYHDNQLDSLINNALQNAPDMQVAEQRIQL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  81 YQARAYAADSSLFPSLDAS------------LTGTRARTQSAATGLPIHSTLYKGGLTASYDVDIWGANRSAANAAGASL 148
Cdd:PRK11459   91 AEAQAKAVAAQDGPQLDFSadmerqkmsaegLMGPFALNDPAAGTTGPWYTNGTFGLTAGWDLDLWGKNRAEVTARIGTV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 149 EAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQADSELRSTRAQIPPL 228
Cdd:PRK11459  171 KARAAEREQTRQLLAGSVARLYWEWQTQAALNTVLQQIEKEQNNIIATDRQLYQNGITSSVEGVETDINASKTRQQLNDV 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 229 QHQIAQQENALSVLLGDNPGAVKrgefaqLTPLRLP---SQLPSTL----LNRRPDIAQAERQLVAADATLASSQAQLLP 301
Cdd:PRK11459  251 AGKMKIIEARLSALTNTQTKSLK------LKPVALPkvaSQLPDELgyslLARRADLQAAHWYIESSLSTIDAAKAAFYP 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 302 SINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEVNDSLDAISR 381
Cdd:PRK11459  325 DINLMAFLQQDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLNANLDIAKAQSNLSIASYNKAVVDAVNDVARAASQVET 404
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1739889105 382 YGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:PRK11459  405 LAEKNQHQQQIERDALRVVGLAQARFNAGIIAGSRVSEAKIPALRERANGLLLQGQWLDASIQLTSAL 472
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
56-449 6.43e-29

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 117.86  E-value: 6.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  56 TLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTqSAATGLPIHSTLYKGGLTASYDVDIW- 134
Cdd:TIGR01844   4 TLLDAVLLALANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSNT-YPTESRGRNTDLNSGSSTLTLSQPLFd 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 135 -GANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQ 213
Cdd:TIGR01844  83 gGSTWNAVRAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDVLQ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 214 ADSELRSTRAQIPPLQHQIAQQENALSVLLGDNPGAVKRGEFAQLTPLRLPSQLPSTLLNRRPDIAQAERQLVAADATLA 293
Cdd:TIGR01844 163 AEARYASARAQLIQAQNNLDDAKAQLRRLVGQPELAPLAVPSFPAELPEPLDQLLEIAEASNPLLLAAQAAVDAARYQVE 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 294 SSQAQLLPSINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVDVSMAQRNQALYSYEKTVRSAFKEVN 373
Cdd:TIGR01844 243 QARAGHLPTLSLTASTGNSDTSSGGSGNSDSDTYSVGLNVSIPLYQGGATSAQVRQAAHQLNQSRSTLESQKRTVRQQVR 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1739889105 374 DSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:TIGR01844 323 NAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNAEQELYQARQELANARYDYLQAQLNLLSAT 398
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
48-449 7.09e-24

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 103.81  E-value: 7.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  48 WWRNFHDSTLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLfpSLDASLTGTRARTQSAATG--------LPI--- 116
Cdd:PRK09915   60 WWKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGS--QLQVAALGMLNRQRVSANGflspyamdAPAlgm 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 117 ---HSTLYKGGLTASYDVDIWGANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDA 193
Cdd:PRK09915  138 dgpYYTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYA 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 194 WRLAKRQFETGYTSRLELMQADSELRSTRAQIPPLQHQIAQQENALSVLLGdnPGAVKRGEFAQLTPLRLPSQLPST--- 270
Cdd:PRK09915  218 VKAHQSKVAHGLEAQVPFHGARAQILAVDKQIAAVKGQITETRESLRALIG--AGASDMPEIKPVALPRVQTGIPATlsy 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 271 -LLNRRPDIaQAERQLVAAD-ATLASSQAQLLPSINLTATGSLQDRTLPDLLDNPLRLWSLGGSILAPLLNRQALNAQVD 348
Cdd:PRK09915  296 eLLARRPDL-QAMRWYVQASlDQVDSARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLE 374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 349 VSMAQRNQALYSYEKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFSTQ 428
Cdd:PRK09915  375 GTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEE 454
                         410       420
                  ....*....|....*....|.
gi 1739889105 429 LSVVQVKNNLLLAQIDLYRAL 449
Cdd:PRK09915  455 MSLLMLDSRRVIQSIQLMKSL 475
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
269-449 1.89e-16

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 77.18  E-value: 1.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 269 STLLNRRPDIAQAERQLVAADATLASSQAQLLPSINLTATGSLQ-DRTLPDLLDNPLRLWSLGGSIlaPLLNRQALNAQV 347
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNsNNSESGGDDPGTGEVGLGLSQ--PLFDGGKRRARV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 348 DVSMAQRNQALYSYEKTVRSAFKEVNDSLDAISRYGEQLTELQEQETVAQETLRIAQNRYRNGYSSYLDVLDAQRTLFST 427
Cdd:pfam02321  79 KAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEA 158
                         170       180
                  ....*....|....*....|..
gi 1739889105 428 QLSVVQVKNNLLLAQIDLYRAL 449
Cdd:pfam02321 159 RLELLNAEADLELALAQLEQLL 180
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
62-244 3.20e-13

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 67.93  E-value: 3.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  62 DQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTQSAATGLPihSTLYKGGLTASYDVDIWGANRSAA 141
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNNSESGGDD--PGTGEVGLGLSQPLFDGGKRRARV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 142 NAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQADSELRST 221
Cdd:pfam02321  79 KAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEA 158
                         170       180
                  ....*....|....*....|...
gi 1739889105 222 RAQIPPLQHQIAQQENALSVLLG 244
Cdd:pfam02321 159 RLELLNAEADLELALAQLEQLLG 181
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
55-218 3.97e-05

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 45.83  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105  55 STLNQYVDQALRYNSDVLIARERVNEYQARAYAADSSLFPSLDASLTGTRARTQSAATGlPIHSTLYKGGLTASYDVDIW 134
Cdd:TIGR01844 211 EPLDQLLEIAEASNPLLLAAQAAVDAARYQVEQARAGHLPTLSLTASTGNSDTSSGGSG-NSDSDTYSVGLNVSIPLYQG 289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 135 GANRSAANAAGASLEAQKAAAAAANLSVASSVAVGYVTLLSLDEQLRVTQQTLTSREDAWRLAKRQFETGYTSRLELMQA 214
Cdd:TIGR01844 290 GATSAQVRQAAHQLNQSRSTLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNA 369

                  ....
gi 1739889105 215 DSEL 218
Cdd:TIGR01844 370 EQEL 373
tolC PRK09465
outer membrane channel protein; Reviewed
288-449 2.60e-03

outer membrane channel protein; Reviewed


Pssm-ID: 236529 [Multi-domain]  Cd Length: 446  Bit Score: 39.92  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 288 ADATLASSQAQLLPSINLTA----------TGSLQDRTLPDLLDNplrlwSLGGSILAPLLNRQALNAQVdvsmaqrNQA 357
Cdd:PRK09465  255 AREQIRLAQAGHMPTLDLTAsygisdtsysGANGTQYDDSDMGQN-----KVGLNLSLPLYSGGAVNSQV-------KQA 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1739889105 358 LYSY--------------EKTVRSAFKEVNDSLDAISRYgeqltelqEQETV-AQETLRIAQNRYRNGYSSYLDVLDAQR 422
Cdd:PRK09465  323 QYNFvgaseqlesahrsvVQTVRSSFNNINASISSINAY--------EQAVVsAQSSLDATEAGYEVGTRTIVDVLDATT 394
                         170       180
                  ....*....|....*....|....*..
gi 1739889105 423 TLFSTQLSVVQVKNNLLLAQIDLYRAL 449
Cdd:PRK09465  395 TLYDAKQQLSNARYNYLINQLNLKQAL 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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