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Conserved domains on  [gi|1736022979|gb|KAA0505750|]
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two-component system sensor histidine kinase QseC [Escherichia coli]

Protein Classification

two-component system sensor histidine kinase QseC( domain architecture ID 11484664)

two-component system sensor histidine kinase QseC is a member of the two-component regulatory system QseB/QseC that activates the flagella regulon by activating transcription of FlhD; QseC activates QseB by phosphorylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 1-449 0e+00

sensor protein QseC; Provisional


:

Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 895.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337    1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337   81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337  161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337  241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337  321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1736022979 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:PRK10337  401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 1-449 0e+00

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 895.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337    1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337   81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337  161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337  241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337  321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1736022979 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:PRK10337  401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 340-449 3.54e-47

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 157.95  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 340 NAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS---FIVRDNGPGVTPEALARIGERFYRPPGQTATGSG 416
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1736022979 417 LGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:cd16940    81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
141-449 9.73e-46

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 161.61  E-value: 9.73e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 141 YRIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLV 220
Cdd:COG0642    14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 221 ESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVaqLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD 300
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETILRSADRLLRLINDLLDLSRLE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 301 SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNA 380
Cdd:COG0642   172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 381 DS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:COG0642   252 EGdrvrISVEDTGPGIPPEDLERIFEPFFRtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 6-434 1.58e-38

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 145.22  E-value: 1.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   6 RLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLK---HGHVD 82
Cdd:TIGR01386   1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEDIKRLQEKIDdllVGHSD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  83 ddaLTFAIFTHDGRMVL------------NDGDNGEDIPYSYQREGfADGQLVGEDDPWRFVWMTSPdgkYRIVVGQEWE 150
Cdd:TIGR01386  81 ---LALSILNPDGRLLFeraqgaalvpavAANDALLELDQADAKMT-HYRSILRSVAALPGGKGRKP---VQITVALDIN 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 151 YREDMaLAivagQLIPWLVALPIMLIIMMVLLGR-----ELAPLNKL-ALALRMRDPDSEKPLNATGVPSEVRPLVESLN 224
Cdd:TIGR01386 154 AHTHL-LD----ALRKWLILIAVLLVLLTALLGWwitrlGLEPLRRLsAVAARISPESLDQRLDPSRAPAELRELAQSFN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 225 QLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAqLSDDDPQARKKALLqlHSGID---RATRLVDQLLTLSRLDS 301
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA-LSQPRTGEEYREVL--ESNLEeleRLSRMVSDMLFLARADN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 302 LDNLQDVAEIPLEDLLqSSVMDIYHTAQQAKiDVRLTLNAHGIKRtGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNAD 381
Cdd:TIGR01386 306 GQLALERVRLDLAAEL-AKVAEYFEPLAEER-GVRIRVEGEGLVR-GDPQMFRRAISNLLSNALRHTPDGGTITVRIERR 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 382 SFIVR----DNGPGVTPEALARIGERFYR-PPGQT--ATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:TIGR01386 383 SDEVRvsvsNPGPGIPPEHLSRLFDRFYRvDPARSnsGEGTGLGLAIVRSIMEAHGGRAS 442
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 362-442 4.07e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 90.79  E-value: 4.07e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  362 DNAVRYSPQGSVVDVTLNAD----SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRtdKRSRKIGGTGLGLSIVKKLVELHGGEISV 94


                   ....*..
gi 1736022979  436 GNAEQGG 442
Cdd:smart00387  95 ESEPGGG 101
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 362-442 4.55e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 90.51  E-value: 4.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDVTLNAD---SFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNA 438
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLVELLGGTITVESE 94


                  ....
gi 1736022979 439 EQGG 442
Cdd:pfam02518  95 PGGG 98
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 1-449 0e+00

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 895.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337    1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337   81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337  161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337  241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337  321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1736022979 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:PRK10337  401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 340-449 3.54e-47

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 157.95  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 340 NAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS---FIVRDNGPGVTPEALARIGERFYRPPGQTATGSG 416
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1736022979 417 LGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:cd16940    81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
141-449 9.73e-46

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 161.61  E-value: 9.73e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 141 YRIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLV 220
Cdd:COG0642    14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 221 ESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVaqLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD 300
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETILRSADRLLRLINDLLDLSRLE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 301 SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNA 380
Cdd:COG0642   172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 381 DS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:COG0642   252 EGdrvrISVEDTGPGIPPEDLERIFEPFFRtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
143-430 5.50e-44

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 158.56  E-value: 5.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 143 IVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVES 222
Cdd:COG5002    71 LLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 223 LNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAQLS-DDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:COG5002   151 VERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLES 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 302 LDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNAD 381
Cdd:COG5002   231 GELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREE 310

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1736022979 382 S----FIVRDNGPGVTPEALARIGERFYR---PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:COG5002   311 DdqvrISVRDTGIGIPEEDLPRIFERFYRvdkSRSRETGGTGLGLAIVKHIVEAHG 366
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
238-448 2.31e-42

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 149.67  E-value: 2.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQ-LHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDL 316
Cdd:COG2205    17 SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEiIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAEL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 317 LQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGPGV 392
Cdd:COG2205    97 LEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGdgvrISVSDNGPGI 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736022979 393 TPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVS 448
Cdd:COG2205   177 PEEELERIFERFYRGDNSRGEgGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVT 233
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 6-434 1.58e-38

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 145.22  E-value: 1.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   6 RLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLK---HGHVD 82
Cdd:TIGR01386   1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEDIKRLQEKIDdllVGHSD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  83 ddaLTFAIFTHDGRMVL------------NDGDNGEDIPYSYQREGfADGQLVGEDDPWRFVWMTSPdgkYRIVVGQEWE 150
Cdd:TIGR01386  81 ---LALSILNPDGRLLFeraqgaalvpavAANDALLELDQADAKMT-HYRSILRSVAALPGGKGRKP---VQITVALDIN 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 151 YREDMaLAivagQLIPWLVALPIMLIIMMVLLGR-----ELAPLNKL-ALALRMRDPDSEKPLNATGVPSEVRPLVESLN 224
Cdd:TIGR01386 154 AHTHL-LD----ALRKWLILIAVLLVLLTALLGWwitrlGLEPLRRLsAVAARISPESLDQRLDPSRAPAELRELAQSFN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 225 QLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAqLSDDDPQARKKALLqlHSGID---RATRLVDQLLTLSRLDS 301
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA-LSQPRTGEEYREVL--ESNLEeleRLSRMVSDMLFLARADN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 302 LDNLQDVAEIPLEDLLqSSVMDIYHTAQQAKiDVRLTLNAHGIKRtGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNAD 381
Cdd:TIGR01386 306 GQLALERVRLDLAAEL-AKVAEYFEPLAEER-GVRIRVEGEGLVR-GDPQMFRRAISNLLSNALRHTPDGGTITVRIERR 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 382 SFIVR----DNGPGVTPEALARIGERFYR-PPGQT--ATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:TIGR01386 383 SDEVRvsvsNPGPGIPPEHLSRLFDRFYRvDPARSnsGEGTGLGLAIVRSIMEAHGGRAS 442
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
148-429 1.27e-36

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 137.79  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 148 EWEYREdmalaIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLF 227
Cdd:PRK10755   53 MKEIRE-----AVASLLVPSLVMVSLTLLICFQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 228 ARTHAMMVRERRFTSDAAHELRSPLTALKVQTEV-AQLSDDDPQArkkallqLHSGIDRATRLVDQLLTLSRL------- 299
Cdd:PRK10755  128 SRLTSTLDQERLFTADVAHELRTPLAGIRLHLELlEKQHHIDVAP-------LIARLDQMMHTVEQLLQLARAgqsfssg 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 300 --DSLDNLQDVAeIPLEDLLqsSVMdiyhtAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVT 377
Cdd:PRK10755  201 hyQTVKLLEDVI-LPSQDEL--SEM-----LEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIK 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1736022979 378 LNAD----SFIVRDNGPGVTPEALARIGERFYRpPGQTATGSGLGLSIVQRIAKLH 429
Cdd:PRK10755  273 LSQEdggaVLAVEDEGPGIDESKCGELSKAFVR-MDSRYGGIGLGLSIVSRITQLH 327
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 245-449 1.12e-31

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 126.11  E-value: 1.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALKVQTEVaqLSDDDPQARKKALLqlhSGID----RATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK11100  264 THELKSPLAAIRGAAEL--LQEDPPPEDRARFT---GNILtqsaRLQQLIDRLLELARLEQRQELEVLEPVALAALLEEL 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 VMDIYHTAQQAKIDVRLTLNAHGIKrtGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVtPE- 395
Cdd:PRK11100  339 VEAREAQAAAKGITLRLRPDDARVL--GDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGeqvaLSVEDQGPGI-PDy 415

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736022979 396 ALARIGERFY---RPPGQTaTGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:PRK11100  416 ALPRIFERFYslpRPANGR-KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 362-449 3.89e-25

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 98.83  E-value: 3.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFG 436
Cdd:cd00075    10 DNALKYSPPGGTIEISLRQEGdgvvLEVEDNGPGIPEEDLERIFERFYRgDKSREGGGTGLGLAIVRRIVEAHGGRITVE 89

                          90
                  ....*....|...
gi 1736022979 437 NAEQGGFEAKVSW 449
Cdd:cd00075    90 SEPGGGTTFTVTL 102
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
174-433 3.10e-23

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 101.77  E-value: 3.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 174 MLIIMMVLLG--RELAPLNKLALALR-MRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRS 250
Cdd:PRK09835  196 LLIVFIVLLAvhKGHAPIRSVSRQIQnITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRT 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 251 PLTALKVQTEVAqLSdddpQARKKALLQ--LHSGID---RATRLVDQLLTLSRldsLDNLQDVAEIPLEDLLQS--SVMD 323
Cdd:PRK09835  276 PITNLITQTEIA-LS----QSRSQKELEdvLYSNLEeltRMAKMVSDMLFLAQ---ADNNQLIPEKKMLDLADEvgKVFD 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 324 IYHTAQQAKiDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTL----NADSFIVRDNGPGVTPEALAR 399
Cdd:PRK09835  348 FFEAWAEER-GVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCqevdHQVQLVVENPGTPIAPEHLPR 426

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1736022979 400 IGERFYR--PPGQ-TATGSGLGLSIVQRIAKLHGMNV 433
Cdd:PRK09835  427 LFDRFYRvdPSRQrKGEGSGIGLAIVKSIVVAHKGTV 463
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
238-423 2.40e-22

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 98.54  E-value: 2.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDS--LDNLQDVAEIPLE- 314
Cdd:PRK11006  205 RNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAapTIDLNEKVDVPMMl 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 315 DLLQSSVMDIYHTAQQAKIDVRltlnaHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDV----TLNADSFIVRDNGP 390
Cdd:PRK11006  285 RVLEREAQTLSQGKHTITFEVD-----NSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVrwqrVPQGAEFSVEDNGP 359

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1736022979 391 GVTPEALARIGERFYR----PPGQTAtGSGLGLSIVQ 423
Cdd:PRK11006  360 GIAPEHIPRLTERFYRvdkaRSRQTG-GSGLGLAIVK 395
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 362-442 4.07e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 90.79  E-value: 4.07e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  362 DNAVRYSPQGSVVDVTLNAD----SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRtdKRSRKIGGTGLGLSIVKKLVELHGGEISV 94


                   ....*..
gi 1736022979  436 GNAEQGG 442
Cdd:smart00387  95 ESEPGGG 101
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 362-442 4.55e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 90.51  E-value: 4.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDVTLNAD---SFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNA 438
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLVELLGGTITVESE 94


                  ....
gi 1736022979 439 EQGG 442
Cdd:pfam02518  95 PGGG 98
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 142-442 9.03e-21

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 93.32  E-value: 9.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVE 221
Cdd:COG4191    42 LLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELER 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 222 SLNQLfARTHAMMVR-ER-----RFTSDAAHELRSPLTALKVQTEVAQL---SDDDPQARKKALLQLHSGIDRATRLVDQ 292
Cdd:COG4191   122 AEEEL-RELQEQLVQsEKlaalgELAAGIAHEINNPLAAILGNAELLRRrleDEPDPEELREALERILEGAERAAEIVRS 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 293 LLTLSRLDSldnlQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVR-----------------------LTLNA-HGIKRTG 348
Cdd:COG4191   201 LRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVEldlppdlppvlgdpgqleqvllnLLINAiDAMEEGE 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 349 QPLLLsllvrnlldnaVRYSPQGSVVDVTlnadsfiVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIA 426
Cdd:COG4191   277 GGRIT-----------ISTRREGDYVVIS-------VRDNGPGIPPEVLERIFEPFFttKPVGK---GTGLGLSISYGIV 335

                         330
                  ....*....|....*.
gi 1736022979 427 KLHGMNVEFGNAEQGG 442
Cdd:COG4191   336 EKHGGRIEVESEPGGG 351
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 245-442 3.42e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 92.33  E-value: 3.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALK-----VQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNlqdvAEIPLEDLLQS 319
Cdd:COG5000   209 AHEIKNPLTPIQlsaerLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLRE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 320 SVMDIYHTAQQAKIDVRLTLNAHGIKRTGqplllsllvrnllD-------------NAVRYSPQGSVVDVTLNADS---- 382
Cdd:COG5000   285 VLALYEPALKEKDIRLELDLDPDLPEVLA-------------DrdqleqvlinllkNAIEAIEEGGEIEVSTRREDgrvr 351

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1736022979 383 FIVRDNGPGVTPEALARIGERFYrppgqT--ATGSGLGLSIVQRIAKLHGMNVEFGNAEQGG 442
Cdd:COG5000   352 IEVSDNGPGIPEEVLERIFEPFF-----TtkPKGTGLGLAIVKKIVEEHGGTIELESRPGGG 408
PRK10604 PRK10604
sensor protein RstB; Provisional
 224-449 4.64e-19

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 88.89  E-value: 4.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 224 NQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVA-QLSDDDPQARKKALLQLHSgidratrLVDQLLTLSRLDSL 302
Cdd:PRK10604  199 NQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSdNLSAAESQALNRDIGQLEA-------LIEELLTYARLDRP 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 303 DNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDvrLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSpqGSVVDVTLNAD- 381
Cdd:PRK10604  272 QNELHLSEPDLPAWLSTHLADIQAVTPEKTVR--LDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDg 347

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 382 ---SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGS-GLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW 449
Cdd:PRK10604  348 nqaCLIVEDDGPGIPPEERERVFEPFVRldPSRDRATGGcGLGLAIVHSIALAMGGSVNCDESELGGARFSFSW 421
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 237-448 1.42e-18

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 86.76  E-value: 1.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 237 ERRFTSDAAHELRSPLTALK--VQTEVAQLSDDDPQARKKALLqlhSGIDRATRLVDQLLTLSRldslDNLQDVAEIPLE 314
Cdd:COG5807   147 AGELAAGIAHEIRNPLTSIKgfLQLLQESREDSEREEYFNIII---SEIDRINTIITELLVLSK----PKKFNFKKLNLN 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 315 DLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGP 390
Cdd:COG5807   220 DVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGdfvvISVKDEGI 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1736022979 391 GVTPEALARIGERFYRPPGQtatGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVS 448
Cdd:COG5807   300 GIPEEVLEKIGEPFFTTKEE---GTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIY 354
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 1-430 1.27e-16

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 82.14  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:COG4251    61 LLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEEL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:COG4251   141 ALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLS 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 161 AG-QLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATgvpseVRPLVESLNQLfarthammvreRR 239
Cdd:COG4251   221 LGgGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEER-----TAELERSNEEL-----------EQ 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 240 FTSDAAHELRSPLTALKVQTE--VAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDnlQDVAEIPLEDLL 317
Cdd:COG4251   285 FAYVASHDLREPLRKISGFSQllEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELL 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 318 QSSVMDIYHTAQQAKIDVRL----TLNAHG----------IkrtgqplllsllvrnllDNAVRYSPQGSVVDVTLNADS- 382
Cdd:COG4251   363 EEVLEDLEPRIEERGAEIEVgplpTVRGDPtllrqvfqnlI-----------------SNAIKYSRPGEPPRIEIGAERe 425

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 383 -----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:COG4251   426 ggewvFSVRDNGIGIDPEYAEKIFEIFQRlHSRDEYEGTGIGLAIVKKIVERHG 479
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 240-435 1.33e-16

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 81.72  E-value: 1.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 240 FTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKaLLQLHSGIDRATRLVDQLLTLSRLDSldnlQDVAEIPLEDLLQS 319
Cdd:COG5808   244 FAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKY-FDIIQEEIQRINQIVSEFLVLGKPTA----KKLELDDLNELIEE 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 320 SVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPE 395
Cdd:COG5808   319 ILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDekavIEVIDNGEGIPED 398

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1736022979 396 ALARIGERFYRPPGqtaTGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:COG5808   399 IIDEIFEPFVTTKE---GGTGLGLSVCKRIVEMHGGEIDI 435
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
166-429 1.60e-16

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 81.52  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 166 PWLVALPIMLII--MMVLLGRELA-PLNKLALA--------LRMrDPDSEkplnaTGvPSEVRPLVESLNQLFARTHAMM 234
Cdd:PRK09470  168 PLLLLLVTMLVStpLLLWLAWSLAkPARKLKNAadevaqgnLRQ-HPELE-----TG-PQEFRQAGASFNQMVTALERMM 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 235 VRERRFTSDAAHELRSPLTALKVQTevaqlsdddpqarkkALLQLHSG-------ID-RATRL---VDQLLTLSRlDSLD 303
Cdd:PRK09470  241 TSQQRLLSDISHELRTPLTRLQLAT---------------ALLRRRQGeskelerIEtEAQRLdsmINDLLVLSR-NQQK 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 304 NLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDvrLTLNAHGIKRT--GQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNAD 381
Cdd:PRK09470  305 NHLERETFKANSLWSEVLEDAKFEAEQMGKS--LTVSAPPGPWPinGNPNALASALENIVRNALRYSHTKIEVAFSVDKD 382

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1736022979 382 --SFIVRDNGPGVTPEALARIGERFYRPpgQTAT-----GSGLGLSIVQRIAKLH 429
Cdd:PRK09470  383 glTITVDDDGPGVPEEEREQIFRPFYRV--DEARdresgGTGLGLAIVENAIQQH 435
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
215-430 4.74e-16

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 80.06  E-value: 4.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 215 EVRPLVESLNQLfARTHAMMVRERR-FTSDAAHELRSPLTALKVQTEVAQlsDDDPQARKKALLQLHSGIDRATRLVDQL 293
Cdd:PRK10549  218 ELGRLAQDFNQL-ASTLEKNEQMRRdFMADISHELRTPLAVLRGELEAIQ--DGVRKFTPESVASLQAEVGTLTKLVDDL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 294 --LTLSRLDSLDNLQdvAEIPLEDLLQSSVMDIYH--TAQQAKIDVRLTLNAhgiKRTGQPLLLSLLVRNLLDNAVRYSP 369
Cdd:PRK10549  295 hqLSLSDEGALAYRK--TPVDLVPLLEVAGGAFRErfASRGLTLQLSLPDSA---TVFGDPDRLMQLFNNLLENSLRYTD 369

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1736022979 370 QGSVVDVTLN--ADSFIV--RDNGPGVTPEALARIGERFYRPPG---QTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK10549  370 SGGSLHISAEqrDKTLRLtfADSAPGVSDEQLQKLFERFYRTEGsrnRASGGSGLGLAICLNIVEAHN 437
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
245-430 1.02e-15

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 78.35  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALKVQTEVAQLSDDDPQARKkaLLQL-HSGIDRATRLVDQLLTLSRLDSLD----NLQDVAE--------- 310
Cdd:COG3852   143 AHEIRNPLTGIRGAAQLLERELPDDELRE--YTQLiIEEADRLNNLVDRLLSFSRPRPPErepvNLHEVLErvlellrae 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 311 --------------IPL----EDLLQSSVMDIYHTAQQA-----KIDVRlTLNAHGIKRTGQPLllsllvrnlldnavry 367
Cdd:COG3852   221 apknirivrdydpsLPEvlgdPDQLIQVLLNLVRNAAEAmpeggTITIR-TRVERQVTLGGLRP---------------- 283

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1736022979 368 spqGSVVDVTlnadsfiVRDNGPGVTPEALARIGERFYrppgqT--ATGSGLGLSIVQRIAKLHG 430
Cdd:COG3852   284 ---RLYVRIE-------VIDNGPGIPEEILDRIFEPFF-----TtkEKGTGLGLAIVQKIVEQHG 333
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-442 9.06e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 70.18  E-value: 9.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALARIGERFY---RPPGQTATgSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16945    14 DNAIDFSPEGGLIALQLEADTegieLLVFDEGSGIPDYALNRVFERFYslpRPHSGQKS-TGLGLAFVQEVAQLHGGRIT 92


                  ....*...
gi 1736022979 435 FGNAEQGG 442
Cdd:cd16945    93 LRNRPDGV 100
envZ PRK09467
osmolarity sensor protein; Provisional
 174-448 4.59e-14

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 73.79  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 174 MLIIMMVLLG---------RELAPLNKLALALRMRD-PDsekPLNATGVpSEVRPLVESLNQLfARTHAMMVRERRF-TS 242
Cdd:PRK09467  160 LAIGLLSVAGgwlfiriqnRPLVALEHAALQVGKGEiPP---PLREYGA-SEVRSVTRAFNQM-AAGIKQLEDDRTLlMA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 243 DAAHELRSPLTALKVQTEVaqLSDDDpQARKKALLqlhSGIDRATRLVDQLLTLSRLDSLDNLQ--DVAEIpLEDLLQSs 320
Cdd:PRK09467  235 GVSHDLRTPLTRIRLATEM--MSEED-GYLAESIN---KDIEECNAIIEQFIDYLRTGQEMPMEmaDLNAL-LGEVIAA- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 vmdiyHTAQQAKIDvrLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSpqGSVVDVTLNADS----FIVRDNGPGVTPEA 396
Cdd:PRK09467  307 -----ESGYEREIE--TALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGkrawFQVEDDGPGIPPEQ 377

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1736022979 397 LARIGERFYRppGQTA---TGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVS 448
Cdd:PRK09467  378 LKHLFQPFTR--GDSArgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAW 430
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-447 5.75e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 67.47  E-value: 5.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSpQGSV---VDVTLNADSFIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16950    10 DNALRYG-GGWVevsSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRgDNARGTSGTGLGLAIVQRISDAHGGSLTLAN 88

                          90
                  ....*....|
gi 1736022979 438 AEQGGFEAKV 447
Cdd:cd16950    89 RAGGGLCARI 98
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-442 2.77e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 65.95  E-value: 2.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDV----TLNADSFIVRDNGPGVTPEALARIGERFYRPPG---QTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16946    14 ENSLRYTDTGGKLRIraaqTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrnRASGGSGLGLAICHNIALAHGGTIS 93


                  ....*...
gi 1736022979 435 FGNAEQGG 442
Cdd:cd16946    94 AEHSPLGG 101
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-449 2.88e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 65.53  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPQGSVVDVTLNADS--FIVRDNGPGVTPEALARIGERFYR--PPGQTATGS-GLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16939    11 NALRYAHRTVRIALLVSGGRltLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGfGLGLAIVHRVALWHGGHVECDD 90

                          90
                  ....*....|..
gi 1736022979 438 AEQGGFEAKVSW 449
Cdd:cd16939    91 SELGGACFRLTW 102
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-444 3.10e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 65.42  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPQGSVVDVTLNAD--SFIVRDNGPGVTPEALARIGERFYRP--PGQTAT-GSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16949    11 NALRYSPSKILLDISQDGDqwTITITDDGPGVPEDQLEQIFLPFYRVdsARDRESgGTGLGLAIAERAIEQHGGKIKASN 90


                  ....*..
gi 1736022979 438 AEQGGFE 444
Cdd:cd16949    91 RKPGGLR 97
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
233-434 5.66e-13

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 70.77  E-value: 5.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 233 MMVRER-----RFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKkALLQLHSGIDRATRLVDQLLTLSRlDSLDNLQD 307
Cdd:PRK11360  381 VARQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQE-YLSVVLREVDRLNKVIDQLLEFSR-PRESQWQP 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 308 VAeipLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVT--LNADSFI- 384
Cdd:PRK11360  459 VS---LNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRtwQYSDGQVa 535

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1736022979 385 --VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:PRK11360  536 vsIEDNGCGIDPELLKKIFDPFFT---TKAKGTGLGLALSQRIINAHGGDIE 584
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-447 2.00e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 63.25  E-value: 2.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPQGSVVDVTLNAD----SFIVRDNGPGVTPEALARIGERFYRppGQTATGS----GLGLSIVQRIAKLHGMNVE 434
Cdd:cd16975    15 NACQYAPEGGTVSISIYDEeeylYFEIWDNGHGFSEQDLKKALELFYR--DDTSRRSgghyGMGLYIAKNLVEKHGGSLI 92

                          90
                  ....*....|...
gi 1736022979 435 FGNAEQGGFEAKV 447
Cdd:cd16975    93 IENSQKGGAEVTV 105
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 363-430 2.52e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 63.28  E-value: 2.52e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1736022979 363 NAVRYSPQGSV-VDVTLNADS-------FIVRDNGPGVTPEALARIGERFYRPPGQT---ATGSGLGLSIVQRIAKLHG 430
Cdd:cd16922    11 NAIKFTEEGEVtLRVSLEEEEedgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkYGGTGLGLAISKKLVELMG 89
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 234-298 3.38e-12

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 61.46  E-value: 3.38e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1736022979 234 MVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSR 298
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 245-435 4.68e-12

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 67.69  E-value: 4.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALKVQTEVAQLSDDDPQarKKALLQLHSGIDRATRLVDQLLTLSRLDSLDnlqdVAEIPLEDLLQSsVMDI 324
Cdd:COG5809   278 AHEIRNPLTSLKGFIQLLKDTIDEEQ--KTYLDIMLSELDRIESIISEFLVLAKPQAIK----YEPKDLNTLIEE-VIPL 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 325 YHTaqQA---KIDVRLTLNAH--GIKrtGQPLLLSLLVRNLLDNAVRYSP-QGSV-VDVTLNADSFI---VRDNGPGVTP 394
Cdd:COG5809   351 LQP--QAllkNVQIELELEDDipDIL--GDENQLKQVFINLLKNAIEAMPeGGNItIETKAEDDDKVvisVTDEGCGIPE 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1736022979 395 EALARIGERFYrppgqTA--TGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:COG5809   427 ERLKKLGEPFY-----TTkeKGTGLGLMVSYKIIEEHGGKITV 464
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 245-432 6.99e-12

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 66.81  E-value: 6.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALKVQTEVAQlSDDDPQARKKALLQLH-SGIDRATRLVDQLLTLSRLDSlDNLQdvaEIPLEDLLQSSVMD 323
Cdd:COG5806   209 AHEVRNPLTVVRGFIQLLQ-EPELSDEKRKQYIRIAlEELDRAEAIITDYLTFAKPQP-EKLE---KIDVSEELEHVIDV 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 324 IYHTAQQAKIDVRLTLNaHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALAR 399
Cdd:COG5806   284 LSPYANMNNVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKEQLER 362

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1736022979 400 IGERFYrppGQTATGSGLGLSIVQRIakLHGMN 432
Cdd:COG5806   363 LGEPYF---STKEKGTGLGTMVSYRI--IEAMN 390
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-429 7.13e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 61.83  E-value: 7.13e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 363 NAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQTAT---GSGLGLSIVQRIAKLH 429
Cdd:cd16952    11 NAVKYTPPSDTITVRWSQEEsgarLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntgGTGLGLAIVKHVMSRH 84
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 238-301 3.26e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 58.73  E-value: 3.26e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979  238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQaRKKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEE-QREYLETILREAERLLRLINDLLDLSRIEA 65
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 363-442 4.43e-11

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 59.81  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPQGSVVDVTLNADS-----FIVRDNGPGVTPEALARIGERFYR---PPGQTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16925    15 NAFKFTPDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQgdgSSTRAHGGTGLGLSIVKEFVELHGGTVT 94


                  ....*...
gi 1736022979 435 FGNAEQGG 442
Cdd:cd16925    95 VSDAPGGG 102
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-442 4.99e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 59.51  E-value: 4.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSV-VDVTL--NADSFI--VRDNGPGVTPEALARIGERFY--RPPGQT-ATGSGLGLSIVQRIAKLHGMNV 433
Cdd:cd16953    10 GNAISFSPPDTGrITVSAmpTGKMVTisVEDEGPGIPQEKLESIFDRFYteRPANEAfGQHSGLGLSISRQIIEAHGGIS 89


                  ....*....
gi 1736022979 434 EFGNAEQGG 442
Cdd:cd16953    90 VAENHNQPG 98
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 238-301 8.32e-11

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 57.61  E-value: 8.32e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1736022979 238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARkKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSRIEA 65
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
245-430 1.18e-10

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 63.27  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALK-VQTEVAQLSDDDPQARKKALLqLHSGIDRATRLVDQLLTLSRLDSLdNLQDVAeipLEDLLQSSVMD 323
Cdd:PRK10364  245 AHEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQV-MAKEADRLNRVVSELLELVKPTHL-ALQAVD---LNDLINHSLQL 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 324 IYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALAR 399
Cdd:PRK10364  320 VSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGagvkISVTDSGKGIAADQLEA 399

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1736022979 400 IGERFYRPPGQtatGSGLGLSIVQRIAKLHG 430
Cdd:PRK10364  400 IFTPYFTTKAE---GTGLGLAVVHNIVEQHG 427
PRK10490 PRK10490
sensor protein KdpD; Provisional
 246-442 2.61e-10

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 62.75  E-value: 2.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 246 HELRSPLTALKVQTEVAQL---SDDDPQARKKAllQLHSGIDRATRLVDQLLTLSRLDSlDNLQDVAE-IPLEDLLQSSV 321
Cdd:PRK10490  673 HDLRTPLTVLFGQAEILTLdlaSEGSPHARQAS--EIRQQVLNTTRLVNNLLDMARIQS-GGFNLRKEwLTLEEVVGSAL 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 322 MDIYHTAQQAKIDVRLT-----LNAHG--IKRTgqplllsllVRNLLDNAVRYS-PQGSV-VDVTLNADSF--IVRDNGP 390
Cdd:PRK10490  750 QMLEPGLSGHPINLSLPepltlIHVDGplFERV---------LINLLENAVKYAgAQAEIgIDAHVEGERLqlDVWDNGP 820

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1736022979 391 GVTPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNVEFGNAEQGG 442
Cdd:PRK10490  821 GIPPGQEQLIFDKFARGNKESAIpGVGLGLAICRAIVEVHGGTIWAENRPEGG 873
PRK09303 PRK09303
histidine kinase;
245-430 3.63e-10

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 61.51  E-value: 3.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTA--LKVQTeVAQLSDDDPQARKKALL-QLHSGIDRATRLVDQLLTlsrldslDNLQdVAEIPLEDL-LQSS 320
Cdd:PRK09303  159 AHDLRTPLTAasLALET-LELGQIDEDTELKPALIeQLQDQARRQLEEIERLIT-------DLLE-VGRTRWEALrFNPQ 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 321 VMDIYHTAQQAKIDVRLTLNAHGIKRT-----------GQPLLLSLLVRNLLDNAVRYSPQGSVVDVT-LNADS----FI 384
Cdd:PRK09303  230 KLDLGSLCQEVILELEKRWLAKSLEIQtdipsdlpsvyADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTqkvqVS 309

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1736022979 385 VRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK09303  310 ICDTGPGIPEEEQERIFEDRVRlPRDEGTEGYGIGLSVCRRIVRVHY 356
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 245-429 1.39e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 60.13  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 245 AHELRSPLTALKVQTEVAQLSDDDpqarKKALLQLH-SGIDRATRLVDQLLTLSRLDSldnlQDVAEIPLEDLLQSSVMD 323
Cdd:COG5805   295 AHEIRNPLTSIKGFLQLLQPGIED----KEEYFDIMlSELDRIESIISEFLALAKPQA----VNKEKENINELIQDVVTL 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 324 IYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDV-TLNADSFI---VRDNGPGVTPEALAR 399
Cdd:COG5805   367 LETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIhTEEEDNSViirVIDEGIGIPEERLKK 446

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1736022979 400 IGERFYrppgQTAT-GSGLGLSIVQRIAKLH 429
Cdd:COG5805   447 LGEPFF----TTKEkGTGLGLMVSYKIIENH 473
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-430 1.41e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 55.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1736022979 363 NAVRYSPQGSVVDVtlnaDSFIVRDN--------GPGVTPEALARIGERFYRppGQTA---TGSGLGLSIVQRIAKLHG 430
Cdd:cd16923    11 NAIKYSPENTRIYI----TSFLTDDVvnimfknpSSHPLDFKLEKLFERFYR--GDNSrntEGAGLGLSIAKAIIELHG 83
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-447 7.34e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 54.18  E-value: 7.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSpqGSVVDVTLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQTAtGSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16954    47 DNACKWC--LEFVEVTARQTDgglhLIVDDDGPGVPESQRSKIFQRGQRLDEQRP-GQGLGLAIAKEIVEQYGGELSLSD 123

                          90
                  ....*....|
gi 1736022979 438 AEQGGFEAKV 447
Cdd:cd16954   124 SPLGGARFEV 133
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 373-434 7.57e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 53.19  E-value: 7.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1736022979 373 VVDVTLNADSFI--VRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16943    26 TIRTWAHVDQVLieVEDTGSGIDPEILGRIFDPFFttKPVGE---GTGLGLSLSYRIIQKHGGTIR 88
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-442 1.41e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 52.33  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGSVVDVTLNAD------SFIVRDNGPGVTPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16921    10 GNAIKFRRPRRPPRIEVGAEdvgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYeGTGVGLAIVRKIIERHGGRIW 89


                  ....*...
gi 1736022979 435 FGNAEQGG 442
Cdd:cd16921    90 LESEPGEG 97
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 362-447 1.95e-08

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 56.01  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAVRYSPQGS----VVDVTLNAD----SFIVRDNGPGVTPEALARIGERFYrpPGQTATGSGLGLSIVQRIAKLHGMNV 433
Cdd:COG3290   291 DNAIEAVEKLPeeerRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGF--STKLGEGRGLGLALVKQIVEKYGGTI 368

                          90
                  ....*....|....*.
gi 1736022979 434 EFGNAEQGG--FEAKV 447
Cdd:COG3290   369 EVESEEGEGtvFTVRL 384
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 384-442 2.51e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 51.69  E-value: 2.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 384 IVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHGMNVEFGNAEQGG 442
Cdd:cd16976    38 VVRDNGPGIAEEHLSRVFDPFFttKPVGK---GTGLGLSISYGIVEEHGGRLSVANEEGAG 95
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
164-449 3.09e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 55.79  E-value: 3.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 164 LIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGvPSEVRPLVESLNQLFARTHAMMVRERRftsd 243
Cdd:COG2972   160 LLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVERIKELIEEVYE---- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 244 aahelrspLTALKVQTEVAQLsdddpQARK------------KALLQLHsGIDRATRLVDQLLTLSRlDSLDNLQDVaeI 311
Cdd:COG2972   235 --------LELEKKEAELKAL-----QAQInphflfntlnsiRWLAELE-DPEEAEEMLEALSKLLR-YSLSKGDEL--V 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 312 PLED---LLQSsvmdiYHTAQQA----KIDVRL-----TLNAHGIKRTGQPLLlsllvrnllDNAVRYS-----PQGSV- 373
Cdd:COG2972   298 TLEEeleLIKS-----YLEIQKLrfgdRLEVEIeideeLLDLLIPKLILQPLV---------ENAIEHGiepkeGGGTIr 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 374 VDVTLNADS--FIVRDNGPGVTPEALARIGERFYRPPGqtatGSGLGLSIV-QRIAKLHGMN--VEFGNAEQGGFEAKVS 448
Cdd:COG2972   364 ISIRKEGDRlvITVEDNGVGMPEEKLEKLLEELSSKGE----GRGIGLRNVrERLKLYYGEEygLEIESEPGEGTTVTIR 439


                  .
gi 1736022979 449 W 449
Cdd:COG2972   440 I 440
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 366-442 1.77e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 49.46  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 366 RYSPQGSV-VDVTLNAD---SFIVRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQG 441
Cdd:cd16944    23 RPSDVGEVrIRVEADQDgriVLIVCDNGKGFPREMRHRATEPYVT---TRPKGTGLGLAIVKKIMEEHGGRISLSNREAG 99


                  .
gi 1736022979 442 G 442
Cdd:cd16944   100 G 100
PRK15347 PRK15347
two component system sensor kinase;
154-430 5.09e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 52.34  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 154 DMALAIVAGQLiPW-LVALPIMLIIMMVLLGRELAplnklalalrmrdpdseKPL-------NATGVPSEVRPLVE---- 221
Cdd:PRK15347  289 NEALKPALQQL-PFaLLILVLLTSVLFLLLRRYLA-----------------KPLwrfvdiiNKTGPAALEPRLPEnrld 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 222 -------SLNQLFA---------------RTHA----------MMVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDP 269
Cdd:PRK15347  351 elgsiakAYNQLLDtlneqydtlenkvaeRTQAlaeakqraeqANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTA 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 270 QARKKALLQLHSGiDRATRLVDQLLTLSRLDSLD---NLQDVAEIPLEDllqSSVMDIYHTAQQAKIDVRLTLNAH---- 342
Cdd:PRK15347  431 EQMDLADTARQCT-LSLLAIINNLLDFSRIESGQmtlSLEETALLPLLD---QAMLTIQGPAQSKSLTLRTFVGAHvply 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 343 ----GIkRTGQplllslLVRNLLDNAVRYSPQGSV---VDVTLNADSFIVRDNGPGVTPEALARIGERFYRPpGQTATGS 415
Cdd:PRK15347  507 lhldSL-RLRQ------ILVNLLGNAVKFTETGGIrlrVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA-DTHSQGT 578

                         330
                  ....*....|....*
gi 1736022979 416 GLGLSIVQRIAKLHG 430
Cdd:PRK15347  579 GLGLTIASSLAKMMG 593
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 385-435 6.39e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 47.78  E-value: 6.39e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 385 VRDNGPGVTPEALARIgerFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:cd16918    48 VIDNGPGIPPDLQDTI---FYPMVSGRENGTGLGLAIAQNIVSQHGGVIEC 95
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
240-430 7.30e-07

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 51.60  E-value: 7.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 240 FTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLdNLQDVAeipLEDLLQS 319
Cdd:PRK13837  453 LASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGER-NTKPFD---LSELVTE 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 320 SVMDI-YHTAQQAKIDVRLTlnAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADSFI-------------- 384
Cdd:PRK13837  529 IAPLLrVSLPPGVELDFDQD--QEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgr 606

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 385 -----VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK13837  607 yvllrVSDTGAGIDEAVLPHIFEPFFT---TRAGGTGLGLATVHGIVSAHA 654
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
252-449 1.67e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 49.23  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 252 LTALKVQTEVAQ-LSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEipLEDLLQSsvmdiyhTAQQ 330
Cdd:COG4585    69 LSAIKLQLEAARrLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAA--LEELAER-------LLRA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 331 AKIDVRLTLnahgikrTGQPLLLSLLVRNLL--------DNAVRYSpQGSVVDVTLNAD----SFIVRDNGPGVTPEAla 398
Cdd:COG4585   140 AGIRVELDV-------DGDPDRLPPEVELALyrivqealTNALKHA-GATRVTVTLEVDdgelTLTVRDDGVGFDPEA-- 209

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1736022979 399 rigerfyrppgqtATGSGLGL-SIVQRIAKLHGmNVEFGNAEQGGFEAKVSW 449
Cdd:COG4585   210 -------------APGGGLGLrGMRERAEALGG-TLTIGSAPGGGTRVRATL 247
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-442 3.35e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 45.36  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 362 DNAV----RYSPQGSVVDVTLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQtaTGSGLGLSIVQRIAKLHGMNV 433
Cdd:cd16915    10 DNALdalaATGAPNKQVEVFLRDEGddlvIEVRDTGPGIAPELRDKVFERGVSTKGQ--GERGIGLALVRQSVERLGGSI 87


                  ....*....
gi 1736022979 434 EFGNAEQGG 442
Cdd:cd16915    88 TVESEPGGG 96
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 382-430 1.02e-05

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 44.68  E-value: 1.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 382 SFIVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHG 430
Cdd:cd16919    49 CLEVSDTGSGMPAEVLRRAFEPFFttKEVGK---GTGLGLSMVYGFVKQSG 96
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 374-442 2.54e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 43.15  E-value: 2.54e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1736022979 374 VDVTLNADSFI---VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGG 442
Cdd:cd16920    28 IRTSPADDRAVtisVKDTGPGIAEEVAGQLFDPFYT---TKSEGLGMGLSICRSIIEAHGGRLSVESPAGGG 96
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-426 8.21e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.12  E-value: 8.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1736022979 362 DNAVRYSPQGSVVDVTLNADS---FI-VRDNGPGVTPEALARIGERFY---RPPGQTATGSGLGLSIVQRIA 426
Cdd:cd16947    30 SNAIKYGSDGKFLGMTLREDEkhvYIdIWDKGKGISETEKDHVFERLYtleDSRNSAKQGNGLGLTITKRLA 101
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
214-427 1.33e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 44.73  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  214 SEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQL 293
Cdd:PRK09959   689 TETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEI 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979  294 LTLSRLDSLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRL--TLNAHGIKRTgQPLLLSLLVRNLLDNAVRYSPQG 371
Cdd:PRK09959   769 LDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCssTFPDHYLVKI-DPQAFKQVLSNLLSNALKFTTEG 847

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1736022979  372 SV--------VDVTLNADSFIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAK 427
Cdd:PRK09959   848 AVkittslghIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQtSAGRQQTGSGLGLMICKELIK 912
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
363-426 1.82e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 41.05  E-value: 1.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 363 NAVRYSPQGS---VVDVTLNADS----FIVRDNGPGVTPEALarigerfyRPPGQTATGSGLGLSIVQRIA 426
Cdd:COG2172    45 NAVRHAYGGDpdgPVEVELELDPdgleIEVRDEGPGFDPEDL--------PDPYSTLAEGGRGLFLIRRLM 107
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 363-430 1.92e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.78  E-value: 1.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1736022979 363 NAVRYSPQGSVVdVTLNADS-----FIVRDNGPGVTPEALARIGERFY----RPPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK11091  409 NAVKFTQQGGVT-VRVRYEEgdmltFEVEDSGIGIPEDELDKIFAMYYqvkdSHGGKPATGTGIGLAVSKRLAQAMG 484
PRK13557 PRK13557
histidine kinase; Provisional
 385-430 2.64e-03

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 40.04  E-value: 2.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1736022979 385 VRDNGPGVTPEALARIGERFYRPPGQtATGSGLGLSIVQRIAKLHG 430
Cdd:PRK13557  329 VTDTGSGMPPEILARVMDPFFTTKEE-GKGTGLGLSMVYGFAKQSG 373
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
213-442 2.74e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 40.00  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 213 PSEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALkvQTEVAQLSDDDP----QARKKALLQ---------- 278
Cdd:PRK10815  242 PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVL--QSTLRSLRSGKQmsveQAEPIMLEQisrisqqigy 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 279 -LHsgidRATRLVDQLLtLSRldsldNLQDVAeiPLEDLLQSSVMDIYhtaqQAKiDVRLTLN-AHGIKRTGQPLLLSLL 356
Cdd:PRK10815  320 yLH----RASMRSEHNL-LSR-----ELHSVA--PLLDNLTSALNKVY----QRK-GVNITLDiSPEITFVGEKNDFMEV 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 357 VRNLLDNAVRYSPQGSVVDVTLNADSF--IVRDNGPGVTPEALARIGERfyrppGQTA----TGSGLGLSIVQRIAKLHG 430
Cdd:PRK10815  383 MGNVLDNACKYCLEFVEISARQTDEHLhiVVEDDGPGIPESKRELIFDR-----GQRAdtlrPGQGLGLSVAREITEQYE 457

                         250
                  ....*....|..
gi 1736022979 431 MNVEFGNAEQGG 442
Cdd:PRK10815  458 GKISAGDSPLGG 469
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 363-426 3.05e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 36.86  E-value: 3.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1736022979 363 NAVRY---SPQGSVVDVTLNADS----FIVRDNGPGVTPEALarigerfyRPPGQTATGSGLGLSIVQRIA 426
Cdd:cd16936    11 NAVRHayrHDGPGPVRLELDLDPdrlrVEVTDSGPGFDPLRP--------ADPDAGLREGGRGLALIRALM 73
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-434 3.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 37.27  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPQGSvvDVTLNADS------FIVRDNGPGVTPEALARIGERFY-----RppgQTATGSGLGLSIVQRIA-KL-H 429
Cdd:cd16948    16 NALKYSKQGG--KIEIYSETneqgvvLSIKDFGIGIPEEDLPRVFDKGFtgengR---NFQESTGMGLYLVKKLCdKLgH 90


                  ....*
gi 1736022979 430 GMNVE 434
Cdd:cd16948    91 KIDVE 95
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-444 3.98e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 36.38  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736022979 363 NAVRYSPqGSVVDVTL-NADSFI---VRDNGPGVTPEAlarigerfyrppgqTATGSGLGLSIVQ-RIAKLHGmNVEFGN 437
Cdd:cd16917    11 NALKHAG-ASRVRVTLsYTADELtltVVDDGVGFDGPA--------------PPGGGGFGLLGMReRAELLGG-TLTIGS 74


                  ....*..
gi 1736022979 438 AEQGGFE 444
Cdd:cd16917    75 RPGGGTR 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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