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Conserved domains on  [gi|1698165623|sp|K7EJ46|]
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RecName: Full=Small integral membrane protein 22; AltName: Full=Cancer-associated small integral membrane open reading frame 1

Protein Classification

DUF4713 domain-containing protein( domain architecture ID 14448725)

DUF4713 domain-containing protein similar to Homo sapiens Small integral membrane proteins, SMIM5, SMIM18 and SMIM22

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CASIMO1_SMIM22 cd20255
small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small ...
 6-83 1.30e-31

small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small integral membrane protein 22 (SMIM22) variant of the Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein). CASIMO1 controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This variant is expressed on chromosome 17 in humans, mostly in the colon and stomach.


:

Pssm-ID: 380777  Cd Length: 80  Bit Score: 105.10  E-value: 1.30e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1698165623  6 EELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPrrESPRKERP-KGVDNLALEP 83
Cdd:cd20255    4 QELEDQINDVLGRLKSKQLFQSDWDIAAFVIFLTFIGTVLLLVLLVLIRCCCCCCCSP--PKSRKVKPgKGVDNLAMEP 80
 
Name Accession Description Interval E-value
CASIMO1_SMIM22 cd20255
small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small ...
 6-83 1.30e-31

small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small integral membrane protein 22 (SMIM22) variant of the Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein). CASIMO1 controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This variant is expressed on chromosome 17 in humans, mostly in the colon and stomach.


Pssm-ID: 380777  Cd Length: 80  Bit Score: 105.10  E-value: 1.30e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1698165623  6 EELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPrrESPRKERP-KGVDNLALEP 83
Cdd:cd20255    4 QELEDQINDVLGRLKSKQLFQSDWDIAAFVIFLTFIGTVLLLVLLVLIRCCCCCCCSP--PKSRKVKPgKGVDNLAMEP 80
DUF4713 pfam15831
Domain of unknown function (DUF4713); This family of proteins is found in eukaryotes. Proteins ...
 6-58 1.11e-16

Domain of unknown function (DUF4713); This family of proteins is found in eukaryotes. Proteins in this family are typically between 68 and 91 amino acids in length. Members are single-pass membrane proteins.


Pssm-ID: 464900  Cd Length: 56  Bit Score: 66.63  E-value: 1.11e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1698165623  6 EELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCC 58
Cdd:pfam15831  1 QEIESTGQEVLLKLQSLQPFQSPWDIAAFSVFLLFIGTVLLLLLLVCLYCCCC 53
 
Name Accession Description Interval E-value
CASIMO1_SMIM22 cd20255
small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small ...
 6-83 1.30e-31

small integral membrane protein 22 (SMIM22) of CASIMO1; This family contains the small integral membrane protein 22 (SMIM22) variant of the Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein). CASIMO1 controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This variant is expressed on chromosome 17 in humans, mostly in the colon and stomach.


Pssm-ID: 380777  Cd Length: 80  Bit Score: 105.10  E-value: 1.30e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1698165623  6 EELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPrrESPRKERP-KGVDNLALEP 83
Cdd:cd20255    4 QELEDQINDVLGRLKSKQLFQSDWDIAAFVIFLTFIGTVLLLVLLVLIRCCCCCCCSP--PKSRKVKPgKGVDNLAMEP 80
CASIMO1 cd20246
Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The ...
 6-73 3.71e-18

Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein), controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This family contains two variants expressed on different chromosomes in humans, small integral membrane protein 5 (SMIM5) and small integral membrane protein 22 (SMIM22).


Pssm-ID: 380775  Cd Length: 68  Bit Score: 70.69  E-value: 3.71e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1698165623  6 EELEATVQEVLGRLKSHQFfQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCCSSPGPRResPRKERP 73
Cdd:cd20246    4 QELQTIGQKVLGKLQSLPF-ASPWEIAAFAIFLLFIGTVLLLLLLACISCCCCCCCSRGR--KSKVQP 68
DUF4713 pfam15831
Domain of unknown function (DUF4713); This family of proteins is found in eukaryotes. Proteins ...
 6-58 1.11e-16

Domain of unknown function (DUF4713); This family of proteins is found in eukaryotes. Proteins in this family are typically between 68 and 91 amino acids in length. Members are single-pass membrane proteins.


Pssm-ID: 464900  Cd Length: 56  Bit Score: 66.63  E-value: 1.11e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1698165623  6 EELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTVLLLLLLVVAHCCCC 58
Cdd:pfam15831  1 QEIESTGQEVLLKLQSLQPFQSPWDIAAFSVFLLFIGTVLLLLLLVCLYCCCC 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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