NCBI Conserved Domain Search

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 ...

688-889

1.31e-151

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 subfamily of receptor-type phosphotyrosine phosphatases (RPTP) is composed of receptor-type tyrosine-protein phosphatase Z (PTPRZ) and G (PTPRG). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. They are type 1 integral membrane proteins consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350397 [Multi-domain] Cd Length: 204 Bit Score: 453.35 E-value: 1.31e-151

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14549     1 YINANYVDGYNKARAYIATQGPLPSTFDDFWRMVWEQNSAIIVMITNLVERGRRKCDQYWPKEGTETYGNIQVTLLSTEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKK--KQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd14549    81 LATYTVRTFSLKNLKLKKvkGRSSERVVYQYHYTQWPDHGVPDYTLPVLSFVRKSSAANPPGAGPIVVHCSAGVGRTGTY 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14549   161 IVIDSMLQQIQDKGTVNVFGFLKHIRTQRNYLVQTEEQYIFIHD 204

PTP_DSP_cys super family

cl28904

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This ...

989-1197

1.82e-90

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This superfamily is composed of cys-based phosphatases, which includes classical protein tyrosine phosphatases (PTPs) as well as dual-specificity phosphatases (DUSPs or DSPs). They are characterized by a CxxxxxR conserved catalytic loop (where C is the catalytic cysteine, x is any amino acid, and R is an arginine). PTPs are part of the tyrosine phosphorylation/dephosphorylation regulatory mechanism, and are important in the response of the cells to physiologic and pathologic changes in their environment. DUSPs show more substrate diversity (including RNA and lipids) and include pTyr, pSer, and pThr phosphatases.

The actual alignment was detected with superfamily member cd14550:

Pssm-ID: 475123 [Multi-domain] Cd Length: 200 Bit Score: 289.99 E-value: 1.82e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTDEEQDYGSFKVKPTGESVA 1067
Cdd:cd14550     1 YINASYLQGYRRSNEFIITQHPLEHTIKDFWQMIWDHNSQTIVMLTDNELNEDePIYWPTKEKPLECETFKVTLSGEDHS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAEEKgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKAFELVKEVgARQERDQNGPVVIVDRYG 1147
Cdd:cd14550    81 CLSNEIR----------LIVRDFILESTQDDYVLEVRQFQCPSWPNPCSPIHTVFELINTV-QEWAQQRDGPIVVHDRYG 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 998470296 1148 GTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14550   150 GVQAATFCALTTLHQQLEHESSVDVYQVAKLYHLMRPGVFTSKEDYQFLY 199

FN3

Fibronectin type 3 domain [General function prediction only];

196-438

1.62e-20

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 97.38 E-value: 1.62e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  196 VIGLKPFTVYSFRVLAVNAIGASKPSKEsFYMVTLREVPEgKPTIVHAQNTSSSSVRIQWTAPARHTIhgefEGYRItYR 275
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNE-VSVTTPTTPPS-APTGLTATADTPGSVTLSWDPVTESDA----TGYRV-YR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  276 prdRTQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVFNPAGR--GPAVVVPVMTDEGVPSSPVNLTAVRVTDTTVRL 353
Cdd:COG3401   269 ---SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  354 KWREPvrPNGVLQGYHVYfqpsRNGSSQQQRKTVSHPQPVEEYMLSGLKPFSFYDIWVKAFTQQHL-GESSNLLKVQTDV 432
Cdd:COG3401   346 SWTAS--SDADVTGYNVY----RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTAS 419


                  ....*.
gi 998470296  433 QGPSAP 438
Cdd:COG3401   420 AASGES 425

PTP_DSP_cys super family

cl28904

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This ...

907-1064

7.54e-17

The actual alignment was detected with superfamily member cd14604:

Pssm-ID: 475123 [Multi-domain] Cd Length: 297 Bit Score: 82.67 E-value: 7.54e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  907 LSRYVQSLQTAQVATTGAGDNEKSWSLLERqfKLVTMFKA-KDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGID 985
Cdd:cd14604     6 LKKFIERVQAMKSTDHNGEDNFASDFMRLR--RLSTKYRTeKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTSSQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  986 GSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDTDEEQ-DYGSFKVKP 1061
Cdd:cd14604    84 DSDYINANFIKGVYGPKAYIATQGPLANTVIDFWRMIWEYNVAIIVMACREFEmgrKKCERYWPLYGEEPmTFGPFRISC 163


                  ...
gi 998470296 1062 TGE 1064
Cdd:cd14604   164 EAE 166

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

133-224

8.15e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 76.77 E-value: 8.15e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  133 PDPPGIPIVVGFTSRSVDLSWTSsPNSHHSVILHYIIHIRIGEKGDWDTMNKVMTsdNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTP-PEDDGGPITGYVVEYREKGSGDWKEVEVTPG--SETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|..
gi 998470296  213 NAIGASKPSKES 224
Cdd:cd00063    78 NGGGESPPSESV 89

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

435-511

9.38e-10

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 9.38e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296  435 PSAPVIVNLTCQSLDSLFLQWERPQTYYNRVDYYFVHYRSEEAWSFEEIAMAANDRLEHVmfIPNLTANTLYEVKVQ 511
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYT--LTGLKPGTEYEFRVR 75

IG_like

smart00410

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

39-129

1.05e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.89 E-value: 1.05e-06

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296     39 VRVGGNATLACPdlPPGAGPPrHLLWWKEDRRLIeATRDRVTVAPDagprvsllPGSSALVFRSVLTQDSGEYQCVVNNR 118
Cdd:smart00410    6 VKEGESVTLSCE--ASGSPPP-EVTWYKQGGKLL-AESGRFSVSRS--------GSTSTLTISNVTPEDSGTYTCAATNS 73

                            90
                    ....*....|..
gi 998470296    119 QG-RRGLVRLFV 129
Cdd:smart00410   74 SGsASSGTTLTV 85

Name

Accession

Description

Interval

E-value

R5-PTPc-1

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 ...

688-889

1.31e-151

Pssm-ID: 350397 [Multi-domain] Cd Length: 204 Bit Score: 453.35 E-value: 1.31e-151

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14549     1 YINANYVDGYNKARAYIATQGPLPSTFDDFWRMVWEQNSAIIVMITNLVERGRRKCDQYWPKEGTETYGNIQVTLLSTEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKK--KQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd14549    81 LATYTVRTFSLKNLKLKKvkGRSSERVVYQYHYTQWPDHGVPDYTLPVLSFVRKSSAANPPGAGPIVVHCSAGVGRTGTY 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14549   161 IVIDSMLQQIQDKGTVNVFGFLKHIRTQRNYLVQTEEQYIFIHD 204

PTPc

Protein tyrosine phosphatase, catalytic domain;

631-893

1.99e-120

Protein tyrosine phosphatase, catalytic domain;

Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 373.53 E-value: 1.99e-120

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    631 GFSREYETFQHCTDPDLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGQkkSSDYINANYIDGYHKSRAFIGTQGPL 710
Cdd:smart00194    1 GLEEEFEKLDRLKPDDESCTVAAFPENRDKNRYKDVLPYDHTRVKLKPPPGE--GSDYINASYIDGPNGPKAYIATQGPL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    711 PATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG--TETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKkqa 788
Cdd:smart00194   79 PSTVEDFWRMVWEQKVTVIVMLTELVEKGREKCAQYWPDEEgePLTYGDITVTLKSVEKVDDYTIRTLEVTNTGCSE--- 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    789 sERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLR 868
Cdd:smart00194  156 -TRTVTHYHYTNWPDHGVPESPESILDLIRAVRKSQSTSTGPIVVHCSAGVGRTGTFIAIDILLQQLEAGKEVDIFEIVK 234

                           250       260
                    ....*....|....*....|....*
gi 998470296    869 HIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:smart00194  235 ELRSQRPGMVQTEEQYIFLYRAILE 259

Y_phosphatase

Protein-tyrosine phosphatase;

657-893

3.69e-110

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 345.00 E-value: 3.69e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   657 NKPKNRYINIVAYDHTRVILKPIPGQkksSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:pfam00102    1 NLEKNRYKDVLPYDHTRVKLTGDPGP---SDYINASYIDGYKKPKKYIATQGPLPNTVEDFWRMVWEEKVTIIVMLTELE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   737 ERGRRKCDMYWP--KEGTETYGIIQVKLVQE-IVMATYTIRTFAIKNIKVKkkqaSERTVYQYHYTNWPDHGVPDHPLPV 813
Cdd:pfam00102   78 EKGREKCAQYWPeeEGESLEYGDFTVTLKKEkEDEKDYTVRTLEVSNGGSE----ETRTVKHFHYTGWPDHGVPESPNSL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   814 LSFVAK-SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:pfam00102  154 LDLLRKvRKSSLDGRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAEGEVDIFQIVKELRSQRPGMVQTLEQYIFLYDAIL 233


                   .
gi 998470296   893 E 893
Cdd:pfam00102  234 E 234

R5-PTP-2

cd14550

PTP-like domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The R5 ...

989-1197

1.82e-90

PTP-like domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The R5 subfamily of receptor-type phosphotyrosine phosphatases (RPTP) is composed of receptor-type tyrosine-protein phosphatase Z (PTPRZ) and G (PTPRG). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. They are type 1 integral membrane proteins consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the inactive PTP-like domain (repeat 2).

Pssm-ID: 350398 [Multi-domain] Cd Length: 200 Bit Score: 289.99 E-value: 1.82e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTDEEQDYGSFKVKPTGESVA 1067
Cdd:cd14550     1 YINASYLQGYRRSNEFIITQHPLEHTIKDFWQMIWDHNSQTIVMLTDNELNEDePIYWPTKEKPLECETFKVTLSGEDHS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAEEKgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKAFELVKEVgARQERDQNGPVVIVDRYG 1147
Cdd:cd14550    81 CLSNEIR----------LIVRDFILESTQDDYVLEVRQFQCPSWPNPCSPIHTVFELINTV-QEWAQQRDGPIVVHDRYG 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 998470296 1148 GTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14550   150 GVQAATFCALTTLHQQLEHESSVDVYQVAKLYHLMRPGVFTSKEDYQFLY 199

PTPc

Protein tyrosine phosphatase, catalytic domain;

933-1198

5.18e-55

Protein tyrosine phosphatase, catalytic domain;

Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 192.49 E-value: 5.18e-55

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    933 LLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGiDGSDYINATFLQGFNRLREFIVTQHPLM 1012
Cdd:smart00194    1 GLEEEFEKLDRLKPDDESCTVAAFPENRDKNRYKDVLPYDHTRVKLKPPPG-EGSDYINASYIDGPNGPKAYIATQGPLP 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1013 DTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPDT-DEEQDYGSFKVKPTGESVAPpvaeekgalmpgeggGLPSR 1088
Cdd:smart00194   80 STVEDFWRMVWEQKVTVIVMLTELVEKGRekcAQYWPDEeGEPLTYGDITVTLKSVEKVD---------------DYTIR 144

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1089 DFILQSTQDDYELACRLLLCPGWPQSCSPL-AKAF-ELVKEVGARQErDQNGPVVIVDRYGGTEAATFCCLSALYRQLER 1166
Cdd:smart00194  145 TLEVTNTGCSETRTVTHYHYTNWPDHGVPEsPESIlDLIRAVRKSQS-TSTGPIVVHCSAGVGRTGTFIAIDILLQQLEA 223

                           250       260       270
                    ....*....|....*....|....*....|..
gi 998470296   1167 EKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:smart00194  224 GKEVDIFEIVKELRSQRPGMVQTEEQYIFLYR 255

Y_phosphatase

Protein-tyrosine phosphatase;

959-1198

2.97e-54

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 189.38 E-value: 2.97e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   959 NKAKNRSLNLIPIESHRVHITPKPGidGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:pfam00102    1 NLEKNRYKDVLPYDHTRVKLTGDPG--PSDYINASYIDGYKKPKKYIATQGPLPNTVEDFWRMVWEEKVTIIVMLTELEE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  1039 KEH---PQFWPDTDEE-QDYGSFKVKPTGEsvappVAEEKGALMpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQS 1114
Cdd:pfam00102   79 KGRekcAQYWPEEEGEsLEYGDFTVTLKKE-----KEDEKDYTV---------RTLEVSNGGSEETRTVKHFHYTGWPDH 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  1115 CSPLAKA--FELVKEVGARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDD 1192
Cdd:pfam00102  145 GVPESPNslLDLLRKVRKSSLDGRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAEGEVDIFQIVKELRSQRPGMVQTLEQ 224


                   ....*.
gi 998470296  1193 FLFLYR 1198
Cdd:pfam00102  225 YIFLYD 230

PHA02738

hypothetical protein; Provisional

650-902

1.26e-50

hypothetical protein; Provisional

Pssm-ID: 222923 [Multi-domain] Cd Length: 320 Bit Score: 182.05 E-value: 1.26e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  650 SYSQLNENKPKNRYINIVAYDHTRVILkpiPGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCII 729
Cdd:PHA02738   42 TFNAEKKNRKLNRYLDAVCFDHSRVIL---PAERNRGDYINANYVDGFEYKKKFICGQAPTRQTCYDFYRMLWMEHVQII 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  730 IMITNLVERGRRKCDMYWP--KEGTETYGIIQVKLVQEIVMATYTIRTfaiknIKVKKKQASERTVYQYHYTNWPDHGVP 807
Cdd:PHA02738  119 VMLCKKKENGREKCFPYWSdvEQGSIRFGKFKITTTQVETHPHYVKST-----LLLTDGTSATQTVTHFNFTAWPDHDVP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  808 DHPLPVLSFV------AKSSAAN----------PPaagPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIR 871
Cdd:PHA02738  194 KNTSEFLNFVlevrqcQKELAQEslqighnrlqPP---PIVVHCNAGLGRTPCYCVVDISISRFDACATVSIPSIVSSIR 270

                         250       260       270
                  ....*....|....*....|....*....|.
gi 998470296  872 QQRNYLVQTEEQYVFIHDALLEAIDSGDTEV 902
Cdd:PHA02738  271 NQRYYSLFIPFQYFFCYRAVKRYVNLTVNKV 301

COG5599

Protein tyrosine phosphatase [Signal transduction mechanisms];

651-887

4.23e-43

Protein tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 444335 [Multi-domain] Cd Length: 282 Bit Score: 158.72 E-value: 4.23e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  651 YSQLNENKPKNRYINIVAYDHTRVilkpipgqKKSSDYINANYIDGYHKSRAfIGTQGPLPATFDDYWRMVWEQRVCIII 730
Cdd:COG5599    36 YLQNINGSPLNRFRDIQPYKETAL--------RANLGYLNANYIQVIGNHRY-IATQYPLEEQLEDFFQMLFDNNTPVLV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  731 MITNLVERGRRKCDM--YWPKEGTETYGIIQVKLVQEIVMATytirTFAIKNIKVKKKQASE--RTVYQYHYTNWPDHGV 806
Cdd:COG5599   107 VLASDDEISKPKVKMpvYFRQDGEYGKYEVSSELTESIQLRD----GIEARTYVLTIKGTGQkkIEIPVLHVKNWPDHGA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  807 PD----HPLpvLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMlRQMRQRQ---SVNVYGFLRHIRQQRNY-LV 878
Cdd:COG5599   183 ISaealKNL--ADLIDKKEKIKDPDKLLPVVHCRAGVGRTGTLIACLAL-SKSINALvqiTLSVEEIVIDMRTSRNGgMV 259


                  ....*....
gi 998470296  879 QTEEQYVFI 887
Cdd:COG5599   260 QTSEQLDVL 268

FN3

Fibronectin type 3 domain [General function prediction only];

196-438

1.62e-20

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 97.38 E-value: 1.62e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  196 VIGLKPFTVYSFRVLAVNAIGASKPSKEsFYMVTLREVPEgKPTIVHAQNTSSSSVRIQWTAPARHTIhgefEGYRItYR 275
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNE-VSVTTPTTPPS-APTGLTATADTPGSVTLSWDPVTESDA----TGYRV-YR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  276 prdRTQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVFNPAGR--GPAVVVPVMTDEGVPSSPVNLTAVRVTDTTVRL 353
Cdd:COG3401   269 ---SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  354 KWREPvrPNGVLQGYHVYfqpsRNGSSQQQRKTVSHPQPVEEYMLSGLKPFSFYDIWVKAFTQQHL-GESSNLLKVQTDV 432
Cdd:COG3401   346 SWTAS--SDADVTGYNVY----RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTAS 419


                  ....*.
gi 998470296  433 QGPSAP 438
Cdd:COG3401   420 AASGES 425

PTPc-N12

cd14604

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein ...

907-1064

7.54e-17

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein phosphatase non-receptor type 12 (PTPN12), also called PTP-PEST or protein-tyrosine phosphatase G1 (PTPG1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling. It regulates various physiological processes, including cell migration, immune response, and neuronal activity, by dephosphorylating multiple substrates including HER2, FAK, PYK2, PSTPIP, WASP, p130Cas, paxillin, Shc, catenin, c-Abl, ArgBP2, p190RhoGAP, RhoGDI, cell adhesion kinase beta, and Rho GTPase.

Pssm-ID: 350452 [Multi-domain] Cd Length: 297 Bit Score: 82.67 E-value: 7.54e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  907 LSRYVQSLQTAQVATTGAGDNEKSWSLLERqfKLVTMFKA-KDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGID 985
Cdd:cd14604     6 LKKFIERVQAMKSTDHNGEDNFASDFMRLR--RLSTKYRTeKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTSSQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  986 GSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDTDEEQ-DYGSFKVKP 1061
Cdd:cd14604    84 DSDYINANFIKGVYGPKAYIATQGPLANTVIDFWRMIWEYNVAIIVMACREFEmgrKKCERYWPLYGEEPmTFGPFRISC 163


                  ...
gi 998470296 1062 TGE 1064
Cdd:cd14604   164 EAE 166

PHA02746

protein tyrosine phosphatase; Provisional

955-1172

7.92e-17

protein tyrosine phosphatase; Provisional

Pssm-ID: 165113 [Multi-domain] Cd Length: 323 Bit Score: 83.15 E-value: 7.92e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  955 VKPCNKAKNRSLNLIPIESHRVHITPKPGI--------DG-----------SDYINATFLQGFNRLREFIVTQHPLMDTM 1015
Cdd:PHA02746   47 LKKENLKKNRFHDIPCWDHSRVVINAHESLkmfdvgdsDGkkievtsednaENYIHANFVDGFKEANKFICAQGPKEDTS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1016 ADFWQMVWDHNSQTIVVLSVVDEKEHPQF--W-PDTDEEQDYGSFKVKPTgesvapPVAEEKgalmpgeggGLPSRDFIL 1092
Cdd:PHA02746  127 EDFFKLISEHESQVIVSLTDIDDDDEKCFelWtKEEDSELAFGRFVAKIL------DIIEEL---------SFTKTRLMI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1093 QSTQDDYELACRLLLCPGWPQSCSP--LAKAFELVKEVGARQER---------DQNGPVVIVDRYGGTEAATFCCLSALY 1161
Cdd:PHA02746  192 TDKISDTSREIHHFWFPDWPDNGIPtgMAEFLELINKVNEEQAElikqadndpQTLGPIVVHCSAGIGRAGTFCAIDNAL 271

                         250
                  ....*....|.
gi 998470296 1162 RQLEREKCVDV 1172
Cdd:PHA02746  272 EQLEKEKEVCL 282

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

133-224

8.15e-17

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 76.77 E-value: 8.15e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  133 PDPPGIPIVVGFTSRSVDLSWTSsPNSHHSVILHYIIHIRIGEKGDWDTMNKVMTsdNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTP-PEDDGGPITGYVVEYREKGSGDWKEVEVTPG--SETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|..
gi 998470296  213 NAIGASKPSKES 224
Cdd:cd00063    78 NGGGESPPSESV 89

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

335-430

1.36e-15

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 73.30 E-value: 1.36e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  335 PSSPVNLTAVRVTDTTVRLKWREPVRPNGVLQGYHVYFQPSRNGSSQQQRKTVShpqPVEEYMLSGLKPFSFYDIWVKAF 414
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPG---SETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 998470296  415 TQQHLGESSNLLKVQT 430
Cdd:cd00063    78 NGGGESPPSESVTVTT 93

fn3

Fibronectin type III domain;

236-322

1.21e-14

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.21e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   236 GKPTIVHAQNTSSSSVRIQWTAParHTIHGEFEGYRITYRPRDRTQEESREIILRDskQTQYTIRNLETFTQYLVSLQVF 315
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAV 76


                   ....*..
gi 998470296   316 NPAGRGP 322
Cdd:pfam00041   77 NGGGEGP 83

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

133-218

1.34e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 70.34 E-value: 1.34e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    133 PDPPGIPIVVGFTSRSVDLSWTSSPNSHHSvilHYIIHIRIGEKGDWDTMNKVMTSDNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 998470296    213 NAIGAS 218
Cdd:smart00060   78 NGAGEG 83

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

236-321

5.03e-14

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 68.41 E-value: 5.03e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    236 GKPTIVHAQNTSSSSVRIQWTAPArhtiHGEFEGYRITYRPRDRTQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVF 315
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP----DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 998470296    316 NPAGRG 321
Cdd:smart00060   78 NGAGEG 83

fn3

Fibronectin type III domain;

134-221

7.62e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 7.62e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   134 DPPGIPIVVGFTSRSVDLSWTSsPNSHHSVILHYIIHIRigEKGDWDTMNKVMTSDNSTNFQVIGLKPFTVYSFRVLAVN 213
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP-PPDGNGPITGYEVEYR--PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*...
gi 998470296   214 AIGASKPS 221
Cdd:pfam00041   78 GGGEGPPS 85

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

435-511

9.38e-10

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 9.38e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296  435 PSAPVIVNLTCQSLDSLFLQWERPQTYYNRVDYYFVHYRSEEAWSFEEIAMAANDRLEHVmfIPNLTANTLYEVKVQ 511
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYT--LTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

435-511

1.05e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 1.05e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296    435 PSAPVIVNLTCQSLDSLFLQWERPQtyYNRVDYYFVHYRSEEAWSFEEIAMAANDRLEHVMFIPNLTANTLYEVKVQ 511
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

IG_like

smart00410

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

39-129

1.05e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.89 E-value: 1.05e-06

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296     39 VRVGGNATLACPdlPPGAGPPrHLLWWKEDRRLIeATRDRVTVAPDagprvsllPGSSALVFRSVLTQDSGEYQCVVNNR 118
Cdd:smart00410    6 VKEGESVTLSCE--ASGSPPP-EVTWYKQGGKLL-AESGRFSVSRS--------GSTSTLTISNVTPEDSGTYTCAATNS 73

                            90
                    ....*....|..
gi 998470296    119 QG-RRGLVRLFV 129
Cdd:smart00410   74 SGsASSGTTLTV 85

pfam00047

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...

37-118

6.22e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.

Pssm-ID: 395002 Cd Length: 86 Bit Score: 45.65 E-value: 6.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    37 LFVRVGGNATLACpdLPPGAGPPRHLLWWKEDRRLIEATRDRVTVAPDagprvsllpGSSALVFRSVLTQDSGEYQCVVN 116
Cdd:pfam00047    6 VTVLEGDSATLTC--SASTGSPGPDVTWSKEGGTLIESLKVKHDNGRT---------TQSSLLISNVTKEDAGTYTCVVN 74


                   ..
gi 998470296   117 NR 118
Cdd:pfam00047   75 NP 76

fn3

Fibronectin type III domain;

436-515

1.74e-05

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 44.33 E-value: 1.74e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   436 SAPVIVNLTCQSLDSLFLQWERPQTYYNRVDYYFVHYRseEAWSFEEIAMAANDRLEHVMFIPNLTANTLYEVKVQGATR 515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR--PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

cd00096

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

45-122

1.14e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 41.55 E-value: 1.14e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296   45 ATLACPdlpPGAGPPRHLLWWKEDRRLIEATRDRVtvapdagprvSLLPGSSALVFRSVLTQDSGEYQCVVNNRQGRR 122
Cdd:cd00096     1 VTLTCS---ASGNPPPTITWYKNGKPLPPSSRDSR----------RSELGNGTLTISNVTLEDSGTYTCVASNSAGGS 65

COG3979

Chitodextrinase [Carbohydrate transport and metabolism];

133-216

2.90e-04

Chitodextrinase [Carbohydrate transport and metabolism];

Pssm-ID: 443178 [Multi-domain] Cd Length: 369 Bit Score: 44.76 E-value: 2.90e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  133 PDPPGIPIVVGFTSRSVDLSWTSSPNShhSVILHYIIHirigEKGDwdtmnKVMTSDNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:COG3979     3 PTAPTGLTASNVTSSSVSLSWDASTDN--VGVTGYDVY----RGGD-----QVATVTGLTAWTVTGLTPGTEYTFTVGAC 71


                  ....
gi 998470296  213 NAIG 216
Cdd:COG3979    72 DAAG 75

Name

Accession

Description

Interval

E-value

R5-PTPc-1

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 ...

688-889

1.31e-151

Pssm-ID: 350397 [Multi-domain] Cd Length: 204 Bit Score: 453.35 E-value: 1.31e-151

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14549     1 YINANYVDGYNKARAYIATQGPLPSTFDDFWRMVWEQNSAIIVMITNLVERGRRKCDQYWPKEGTETYGNIQVTLLSTEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKK--KQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd14549    81 LATYTVRTFSLKNLKLKKvkGRSSERVVYQYHYTQWPDHGVPDYTLPVLSFVRKSSAANPPGAGPIVVHCSAGVGRTGTY 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14549   161 IVIDSMLQQIQDKGTVNVFGFLKHIRTQRNYLVQTEEQYIFIHD 204

R-PTPc-G-1

cd17667

catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1; Receptor-type ...

632-895

2.41e-135

catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1; Receptor-type tyrosine-protein phosphatase G (PTPRG), also called protein-tyrosine phosphatase gamma (R-PTP-gamma), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRG is an important tumor suppressor gene in multiple human cancers such as lung, ovarian, and breast cancers. It is widely expressed in many tissues, including the central nervous system, where it plays a role during neuroinflammation processes. It can dephosphorylate platelet-derived growth factor receptor beta (PDGFRB) and may play a role in PDGFRB-related infantile myofibromatosis. PTPRG has four splicing isoforms: three transmembrane isoforms, PTPRG-A, B, and C, and one secretory isoform, PTPRG-S, which are expressed in many tissues including the brain. PTPRG is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350505 [Multi-domain] Cd Length: 274 Bit Score: 413.66 E-value: 2.41e-135

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  632 FSREYETFQHCT-DPDLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGQ-KKSSDYINANYIDGYHKSRAFIGTQGP 709
Cdd:cd17667     1 FSEDFEEVQRCTaDMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYVDGYNKAKAYIATQGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  710 LPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKKQA- 788
Cdd:cd17667    81 LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKg 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  789 ------SERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVN 862
Cdd:cd17667   161 npkgrqNERTVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARTPEMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVN 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 998470296  863 VYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd17667   241 VLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 273

R-PTPc-LAR-1

cd14553

catalytic domain of LAR family receptor-type tyrosine-protein phosphatases, repeat 1; The LAR ...

657-897

2.00e-129

catalytic domain of LAR family receptor-type tyrosine-protein phosphatases, repeat 1; The LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs) include three vertebrate members: LAR (or PTPRF), R-PTP-delta (or PTPRD), and R-PTP-sigma (or PTPRS). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules; they bind to distinct synaptic membrane proteins and are physiologically responsible for mediating presynaptic development by shaping various synaptic adhesion pathways. They play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. LAR-RPTPs contain an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350401 [Multi-domain] Cd Length: 238 Bit Score: 396.38 E-value: 2.00e-129

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:cd14553     3 NKPKNRYANVIAYDHSRVILQPIEGVP-GSDYINANYCDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTKLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  737 ERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKKqaseRTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14553    82 ERSRVKCDQYWPTRGTETYGLIQVTLLDTVELATYTVRTFALHKNGSSEK----REVRQFQFTAWPDHGVPEHPTPFLAF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  817 VAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAID 896
Cdd:cd14553   158 LRRVKACNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVT 237


                  .
gi 998470296  897 S 897
Cdd:cd14553   238 C 238

PTPc

Protein tyrosine phosphatase, catalytic domain;

631-893

1.99e-120

Protein tyrosine phosphatase, catalytic domain;

Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 373.53 E-value: 1.99e-120

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    631 GFSREYETFQHCTDPDLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGQkkSSDYINANYIDGYHKSRAFIGTQGPL 710
Cdd:smart00194    1 GLEEEFEKLDRLKPDDESCTVAAFPENRDKNRYKDVLPYDHTRVKLKPPPGE--GSDYINASYIDGPNGPKAYIATQGPL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    711 PATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG--TETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKkqa 788
Cdd:smart00194   79 PSTVEDFWRMVWEQKVTVIVMLTELVEKGREKCAQYWPDEEgePLTYGDITVTLKSVEKVDDYTIRTLEVTNTGCSE--- 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    789 sERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLR 868
Cdd:smart00194  156 -TRTVTHYHYTNWPDHGVPESPESILDLIRAVRKSQSTSTGPIVVHCSAGVGRTGTFIAIDILLQQLEAGKEVDIFEIVK 234

                           250       260
                    ....*....|....*....|....*
gi 998470296    869 HIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:smart00194  235 ELRSQRPGMVQTEEQYIFLYRAILE 259

R-PTPc-F-1

cd14626

catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1; Receptor-type ...

615-895

1.51e-114

catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1; Receptor-type tyrosine-protein phosphatase F (PTPRF), also known as leukocyte common antigen related (LAR), is the prototypical member of the LAR family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRF/LAR plays a role for LAR in cadherin complexes where it associates with and dephosphorylates beta-catenin, a pathway which may be critical for cadherin complex stability and cell-cell association. It also regulates focal adhesions through cyclin-dependent kinase-1 and is involved in axon guidance in the developing nervous system. It also functions in regulating insulin signaling. PTPRF contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350474 [Multi-domain] Cd Length: 276 Bit Score: 358.58 E-value: 1.51e-114

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  615 SQWAKHVADLHADGDIGFSREYETFqhctDP--DLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINAN 692
Cdd:cd14626     1 SDLADNIERLKANDGLKFSQEYESI----DPgqQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSVDGVP-GSDYINAN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  693 YIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYT 772
Cdd:cd14626    76 YIDGYRKQNAYIATQGPLPETLSDFWRMVWEQRTATIVMMTRLEEKSRVKCDQYWPIRGTETYGMIQVTLLDTVELATYS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  773 IRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAML 852
Cdd:cd14626   156 VRTFALY----KNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPPDAGPMVVHCSAGVGRTGCFIVIDAML 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 998470296  853 RQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd14626   232 ERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAA 274

Y_phosphatase

Protein-tyrosine phosphatase;

657-893

3.69e-110

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 345.00 E-value: 3.69e-110

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   657 NKPKNRYINIVAYDHTRVILKPIPGQkksSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:pfam00102    1 NLEKNRYKDVLPYDHTRVKLTGDPGP---SDYINASYIDGYKKPKKYIATQGPLPNTVEDFWRMVWEEKVTIIVMLTELE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   737 ERGRRKCDMYWP--KEGTETYGIIQVKLVQE-IVMATYTIRTFAIKNIKVKkkqaSERTVYQYHYTNWPDHGVPDHPLPV 813
Cdd:pfam00102   78 EKGREKCAQYWPeeEGESLEYGDFTVTLKKEkEDEKDYTVRTLEVSNGGSE----ETRTVKHFHYTGWPDHGVPESPNSL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   814 LSFVAK-SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:pfam00102  154 LDLLRKvRKSSLDGRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAEGEVDIFQIVKELRSQRPGMVQTLEQYIFLYDAIL 233


                   .
gi 998470296   893 E 893
Cdd:pfam00102  234 E 234

R-PTPc-D-1

cd14624

catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1; Receptor-type ...

609-899

3.27e-108

catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1; Receptor-type tyrosine-protein phosphatase D (PTPRD), also known as receptor-type tyrosine-protein phosphatase delta (R-PTP-delta), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules that play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. PTPRD is involved in pre-synaptic differentiation through interaction with SLITRK2. It contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350472 [Multi-domain] Cd Length: 284 Bit Score: 341.71 E-value: 3.27e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  609 YASVHVSQWAKHVADLHADGDIGFSREYETFqhctDP--DLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGqKKSS 686
Cdd:cd14624     1 HPPIPILELADHIERLKANDNLKFSQEYESI----DPgqQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEG-IPGS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  687 DYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEI 766
Cdd:cd14624    76 DYINANYIDGYRKQNAYIATQGALPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETYGLIQVTLLDTV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  767 VMATYTIRTFAIknikVKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYI 846
Cdd:cd14624   156 ELATYCVRTFAL----YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 998470296  847 VLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAIDSGD 899
Cdd:cd14624   232 VIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN 284

R-PTPc-S-1

cd14625

catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1; Receptor-type ...

612-895

2.30e-107

catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1; Receptor-type tyrosine-protein phosphatase S (PTPRS), also known as receptor-type tyrosine-protein phosphatase sigma (R-PTP-sigma), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRS is a receptor for glycosaminoglycans, including heparan sulfate proteoglycan and neural chondroitin sulfate proteoglycans (CSPGs), which present a barrier to axon regeneration. It also plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. PTPRS contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350473 [Multi-domain] Cd Length: 282 Bit Score: 339.38 E-value: 2.30e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  612 VHVSQWAKHVADLHADGDIGFSREYETFqhctDP--DLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIPGqKKSSDYI 689
Cdd:cd14625     4 IPISELAEHTERLKANDNLKLSQEYESI----DPgqQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG-IMGSDYI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  690 NANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMA 769
Cdd:cd14625    79 NANYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTKLEEKSRIKCDQYWPSRGTETYGMIQVTLLDTIELA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  770 TYTIRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLD 849
Cdd:cd14625   159 TFCVRTFSLH----KNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 998470296  850 AMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd14625   235 AMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAV 280

R-PTPc-Z-1

cd17668

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 1; Receptor-type ...

688-892

7.75e-103

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 1; Receptor-type tyrosine-protein phosphatase Z (PTPRZ), also called receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Three isoforms are generated by alternative splicing from a single PTPRZ gene: two transmembrane isoforms, PTPRZ-A and PTPRZ-B, and one secretory isoform, PTPRZ-S (also known as phosphacan); all are preferentially expressed in the central nervous system (CNS) as chondroitin sulfate (CS) proteoglycans. PTPRZ isoforms play important roles in maintaining oligodendrocyte precursor cells in an undifferentiated state. PTPRZ is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350506 [Multi-domain] Cd Length: 209 Bit Score: 324.24 E-value: 7.75e-103

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd17668     1 YINANYVDGYNKPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKKK----QASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTG 843
Cdd:cd17668    81 LAYYTVRNFTLRNTKIKKGsqkgRPSGRVVTQYHYTQWPDMGVPEYTLPVLTFVRKASYAKRHAVGPVVVHCSAGVGRTG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 998470296  844 TYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:cd17668   161 TYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDALV 209

PTPc

cd00047

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1. ...

688-889

5.51e-93

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG, and are characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active.

Pssm-ID: 350343 [Multi-domain] Cd Length: 200 Bit Score: 296.89 E-value: 5.51e-93

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG--TETYGIIQVKLVQE 765
Cdd:cd00047     1 YINASYIDGYRGPKEYIATQGPLPNTVEDFWRMVWEQKVSVIVMLTNLVEKGREKCERYWPEEGgkPLEYGDITVTLVSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  766 IVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd00047    81 EELSDYTIRTLELSPKGCSE----SREVTHLHYTGWPDHGVPSSPEDLLALVRRVRKEARKPNGPIVVHCSAGVGRTGTF 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd00047   157 IAIDILLERLEAEGEVDVFEIVKALRKQRPGMVQTLEQYEFIYE 200

R3-PTPc

cd14548

catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar ...

662-888

1.88e-92

catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar proteins; R3 subfamily receptor-type phosphotyrosine phosphatases (RPTP) are characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. Vertebrate members include receptor-type tyrosine-protein phosphatase-like O (PTPRO), J (PTPRJ), Q (PTPRQ), B (PTPRB), V (PTPRV) and H (PTPRH). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Most members are PTPs, except for PTPRQ, which dephosphorylates phosphatidylinositide substrates. PTPRV is characterized only in rodents; its function has been lost in humans. Both vertebrate and invertebrate R3 subfamily RPTPs are involved in the control of a variety of cellular processes, including cell growth, differentiation, mitotic cycle and oncogenic transformation.

Pssm-ID: 350396 [Multi-domain] Cd Length: 222 Bit Score: 296.57 E-value: 1.88e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  662 RYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRR 741
Cdd:cd14548     1 RYTNILPYDHSRVKLIPINEEE-GSDYINANYIPGYNSPREFIATQGPLPGTKDDFWRMVWEQNSHTIVMLTQCMEKGRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  742 KCDMYWPKEGTET-YGIIQVKLVQEIVMATYTIRTFAIKNIkvkkkqASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKS 820
Cdd:cd14548    80 KCDHYWPFDQDPVyYGDITVTMLSESVLPDWTIREFKLERG------DEVRSVRQFHFTAWPDHGVPEAPDSLLRFVRLV 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296  821 SAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14548   154 RDYIKQEKGPTIVHCSAGVGRTGTFIALDRLLQQIESEDYVDIFGIVYDLRKHRPLMVQTEAQYIFLH 221

R5-PTP-2

cd14550

PTP-like domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The R5 ...

989-1197

1.82e-90

Pssm-ID: 350398 [Multi-domain] Cd Length: 200 Bit Score: 289.99 E-value: 1.82e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTDEEQDYGSFKVKPTGESVA 1067
Cdd:cd14550     1 YINASYLQGYRRSNEFIITQHPLEHTIKDFWQMIWDHNSQTIVMLTDNELNEDePIYWPTKEKPLECETFKVTLSGEDHS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAEEKgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKAFELVKEVgARQERDQNGPVVIVDRYG 1147
Cdd:cd14550    81 CLSNEIR----------LIVRDFILESTQDDYVLEVRQFQCPSWPNPCSPIHTVFELINTV-QEWAQQRDGPIVVHDRYG 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 998470296 1148 GTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14550   150 GVQAATFCALTTLHQQLEHESSVDVYQVAKLYHLMRPGVFTSKEDYQFLY 199

R-PTPc-M-1

cd14633

catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1; Receptor-type ...

619-894

5.52e-85

catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1; Receptor-type tyrosine-protein phosphatase M (PTPRM), also known as protein-tyrosine phosphatase mu (R-PTP-mu or PTPmu), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRM/PTPmu is a homophilic cell adhesion molecule expressed in CNS neurons and glia. It is required for E-, N-, and R-cadherin-dependent neurite outgrowth. Loss of PTPmu contributes to tumor cell migration and dispersal of human glioblastomas. PTPRM contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350481 [Multi-domain] Cd Length: 273 Bit Score: 278.08 E-value: 5.52e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  619 KHVADLHADGDIGFSREYETFQHCTDPDLTSSysQLNENKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYH 698
Cdd:cd14633     4 QHITQMKCAEGYGFKEEYESFFEGQSAPWDSA--KKDENRMKNRYGNIIAYDHSRVRLQPIEGET-SSDYINGNYIDGYH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  699 KSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEgTETYGIIQVKLVQEIVMATYTIRTFAi 778
Cdd:cd14633    81 RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFA- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  779 knikVKKKQASE-RTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQ 857
Cdd:cd14633   159 ----VEKRGVHEiREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAER 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 998470296  858 RQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14633   235 EGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA 271

R-PTPc-A-1

cd14621

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1; Receptor-type ...

606-902

6.05e-85

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1; Receptor-type tyrosine-protein phosphatase A (PTPRA), also known as receptor-type tyrosine-protein phosphatase alpha (R-PTP-alpha), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA is a positive regulator of Src and Src family kinases via dephosphorylation of the Src-inhibitory tyrosine 527. Thus, it affects transformation and tumorigenesis, inhibition of proliferation, cell cycle arrest, integrin signaling, neuronal differentiation and outgrowth, and ion channel activity. It is also involved in interleukin-1 signaling in fibroblasts through its interaction with the focal adhesion targeting domain of focal adhesion kinase. PTPRA comprises a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the first catalytic PTP domain (repeat 1).

Pssm-ID: 350469 [Multi-domain] Cd Length: 296 Bit Score: 278.83 E-value: 6.05e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  606 DSEYASVHVSQWAKHVADLHADGDIGFSREYETFQHCTDPDLTSSYSQlNENKPKNRYINIVAYDHTRVILKPIPGQKkS 685
Cdd:cd14621     2 NRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASK-EENKEKNRYVNILPYDHSRVHLTPVEGVP-D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  686 SDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQE 765
Cdd:cd14621    80 SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  766 IVMATYTIRTFAIKNIKVKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd14621   160 TVLVDYTVRKFCIQQVGDVTNKKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKNCNPQYAGAIVVHCSAGVGRTGTF 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAIDSGDTEV 902
Cdd:cd14621   240 IVIDAMLDMMHAERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTEL 296

R-PTPc-E-1

cd14620

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1; Receptor-type ...

663-893

1.31e-82

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1; Receptor-type tyrosine-protein phosphatase E (PTPRE), also known as receptor-type tyrosine-protein phosphatase epsilon (R-PTP-epsilon), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. The PTPRE gene contains two distinct promoters that generate the two major isoforms: transmembrane (receptor type RPTPe or PTPeM) and cytoplasmic (cyt-PTPe or PTPeC). Receptor type RPTPe plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells, and may also play a role in osteoclast formation and function. It also negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis. cyt-PTPe acts as a negative regulator of insulin receptor signaling in skeletal muscle. It regulates insulin-induced phosphorylation of proteins downstream of the insulin receptor. Receptor type RPTPe contains a small extracellular region, a single transmembrane segment, and an intracellular region two tandem catalytic PTP domains. This model represents the first PTP domain (repeat 1).

Pssm-ID: 350468 [Multi-domain] Cd Length: 229 Bit Score: 269.50 E-value: 1.31e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  663 YINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRK 742
Cdd:cd14620     1 YPNILPYDHSRVILSQLDGIP-CSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  743 CDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKKQASeRTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSA 822
Cdd:cd14620    80 CYQYWPDQGCWTYGNIRVAVEDCVVLVDYTIRKFCIQPQLPDGCKAP-RLVTQLHFTSWPDFGVPFTPIGMLKFLKKVKS 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296  823 ANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14620   159 VNPVHAGPIVVHCSAGVGRTGTFIVIDAMIDMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYSFIYQALLE 229

R-PTPc-T-1

cd14630

catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1; Receptor-type ...

655-894

1.42e-82

catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1; Receptor-type tyrosine-protein phosphatase T (PTPRT), also known as receptor-type tyrosine-protein phosphatase rho (RPTP-rho or PTPrho), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRT is highly expressed in the nervous system and it plays a critical role in regulation of synaptic formation and neuronal development. It dephosphorylates a specific tyrosine residue in syntaxin-binding protein 1, a key component of synaptic vesicle fusion machinery, and regulates its binding to syntaxin 1. PTPRT has been identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350478 [Multi-domain] Cd Length: 237 Bit Score: 269.59 E-value: 1.42e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  655 NENKPKNRYINIVAYDHTRVILKPIPGQKKSsDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITN 734
Cdd:cd14630     1 DENRNKNRYGNIISYDHSRVRLQLLDGDPHS-DYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASVVMVTN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  735 LVERGRRKCDMYWPKEgTETYGIIQVKLVQEIVMATYTIRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVL 814
Cdd:cd14630    80 LVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQ----KKGYHEIREIRQFHFTSWPDHGVPCYATGLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  815 SFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14630   155 GFVRQVKFLNPPDAGPIVVHCSAGAGRTGCFIAIDIMLDMAENEGVVDIFNCVRELRAQRVNMVQTEEQYVFVHDAILEA 234

R-PTPc-typeIIb-1

cd14555

catalytic domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, ...

688-894

1.58e-79

catalytic domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The type II (or R2B) subfamily of receptor protein tyrosine phosphatases (RPTPs) include the prototypical member PTPmu (or PTPRM), PCP-2 (or PTPRU), PTPrho (or PTPRT), and PTPkappa (or PTPRK). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Type IIb RPTPs mediate cell-cell adhesion though homophilic interactions; their ligand is an identical molecule on an adjacent cell. No heterophilic interactions between the subfamily members have been observed. They also commonly function as tumor suppressors. They contain an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350403 [Multi-domain] Cd Length: 204 Bit Score: 259.85 E-value: 1.58e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPkEGTETYGIIQVKLVQEIV 767
Cdd:cd14555     1 YINANYIDGYHRPNHYIATQGPMQETVYDFWRMVWQENSASIVMVTNLVEVGRVKCSRYWP-DDTEVYGDIKVTLVETEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIV 847
Cdd:cd14555    80 LAEYVVRTFALE----RRGYHEIREVRQFHFTGWPDHGVPYHATGLLGFIRRVKASNPPSAGPIVVHCSAGAGRTGCYIV 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 998470296  848 LDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14555   156 IDIMLDMAEREGVVDIYNCVKELRSRRVNMVQTEEQYIFIHDAILEA 202

PTPc-N9

cd14543

catalytic domain of tyrosine-protein phosphatase non-receptor type 9; Tyrosine-protein ...

631-888

2.03e-78

catalytic domain of tyrosine-protein phosphatase non-receptor type 9; Tyrosine-protein phosphatase non-receptor type 9 (PTPN9), also called protein-tyrosine phosphatase MEG2, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN9 plays an important role in promoting intracellular secretary vesicle fusion in hematopoietic cells and promotes the dephosphorylation of ErbB2 and EGFR in breast cancer cells, leading to impaired activation of STAT5 and STAT3. It also directly dephosphorylates STAT3 at the Tyr705 residue, resulting in its inactivation. PTPN9 has been found to be dysregulated in various human cancers, including breast, colorectal, and gastric cancer.

Pssm-ID: 350391 [Multi-domain] Cd Length: 271 Bit Score: 259.60 E-value: 2.03e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  631 GFSREYE---------TFQHctdpdltssySQLNENKPKNRYINIVAYDHTRVILKPIPGQKKSsDYINANYIDGYHKSR 701
Cdd:cd14543     4 GIYEEYEdirreppagTFLC----------SLAPANQEKNRYGDVLCLDQSRVKLPKRNGDERT-DYINANFMDGYKQKN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  702 AFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG--TETYGIIQVKLVQEIVMATYTIRTFAIK 779
Cdd:cd14543    73 AYIATQGPLPKTYSDFWRMVWEQKVLVIVMTTRVVERGRVKCGQYWPLEEgsSLRYGDLTVTNLSVENKEHYKKTTLEIH 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  780 NIKVKKKqaseRTVYQYHYTNWPDHGVPDHPLPVLSFVAK-----SSAANP--------PAAGPMIVHCSAGVGRTGTYI 846
Cdd:cd14543   153 NTETDES----RQVTHFQFTSWPDFGVPSSAAALLDFLGEvrqqqALAVKAmgdrwkghPPGPPIVVHCSAGIGRTGTFC 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 998470296  847 VLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14543   229 TLDICLSQLEDVGTLNVMQTVRRMRTQRAFSIQTPDQYYFCY 270

R-PTPc-H

cd14619

catalytic domain of receptor-type tyrosine-protein phosphatase H; Receptor-type ...

661-895

3.17e-78

catalytic domain of receptor-type tyrosine-protein phosphatase H; Receptor-type tyrosine-protein phosphatase H (PTPRH or R-PTP-H), also known as stomach cancer-associated protein tyrosine phosphatase 1 (SAP-1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRH is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is localized specifically at microvilli of the brush border in gastrointestinal epithelial cells. It plays a role in intestinal immunity by regulating CEACAM20 through tyrosine dephosphorylation. It is also a negative regulator of integrin-mediated signaling and may contribute to contact inhibition of cell growth and motility.

Pssm-ID: 350467 [Multi-domain] Cd Length: 233 Bit Score: 257.51 E-value: 3.17e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKPIPgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGR 740
Cdd:cd14619     1 NRFRNVLPYDWSRVPLKPIH-EEPGSDYINANYMPGYWSSQEFIATQGPLPQTVGDFWRMIWEQQSSTIVMLTNCMEAGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  741 RKCDMYWPKEGTE-TYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSF--V 817
Cdd:cd14619    80 VKCEHYWPLDYTPcTYGHLRVTVVSEEVMENWTVREFLLKQ----VEEQKTLSVRHFHFTAWPDHGVPSSTDTLLAFrrL 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296  818 AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd14619   156 LRQWLDQTMSGGPTVVHCSAGVGRTGTLIALDVLLQQLQSEGLLGPFSFVQKMRENRPLMVQTESQYVFLHQCILDFL 233

R-PTPc-J

cd14615

catalytic domain of receptor-type tyrosine-protein phosphatase J; Receptor-type ...

661-893

1.26e-77

catalytic domain of receptor-type tyrosine-protein phosphatase J; Receptor-type tyrosine-protein phosphatase J (PTPRJ or R-PTP-J), also known as receptor-type tyrosine-protein phosphatase eta (R-PTP-eta) or density-enhanced phosphatase 1 (DEP-1) OR CD148, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRJ is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats (eight in PTPRJ) and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is expressed in various cell types including epithelial, hematopoietic, and endothelial cells. It plays a role in cell adhesion, migration, proliferation and differentiation. It dephosphorylates or contributes to the dephosphorylation of various substrates including protein kinases such as FLT3, PDGFRB, MET, RET (variant MEN2A), VEGFR-2, LYN, SRC, MAPK1, MAPK3, and EGFR, as well as PIK3R1 and PIK3R2.

Pssm-ID: 350463 [Multi-domain] Cd Length: 229 Bit Score: 255.51 E-value: 1.26e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKpIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGR 740
Cdd:cd14615     1 NRYNNVLPYDISRVKLS-VQSHS-TDDYINANYMPGYNSKKEFIAAQGPLPNTVKDFWRMVWEKNVYAIVMLTKCVEQGR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  741 RKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKKqaseRTVYQYHYTNWPDHGVPDHPLPVLSF---V 817
Cdd:cd14615    79 TKCEEYWPSKQKKDYGDITVTMTSEIVLPEWTIRDFTVKNAQTNES----RTVRHFHFTSWPDHGVPETTDLLINFrhlV 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296  818 AKSSAANPPaAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14615   155 REYMKQNPP-NSPILVHCSAGVGRTGTFIAIDRLIYQIENENVVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCALD 229

PTPc-N11_6

cd14544

catalytic domain of tyrosine-protein phosphatase non-receptor type 11 and type 6; ...

657-897

7.75e-77

catalytic domain of tyrosine-protein phosphatase non-receptor type 11 and type 6; Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) and type 6 (PTPN6) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN11 and PTPN6, are also called SH2 domain-containing tyrosine phosphatase 2 (SHP2) and 1 (SHP1), respectively. They contain two tandem SH2 domains: a catalytic PTP domain, and a C-terminal tail with regulatory properties. Although structurally similar, they have different localization and different roles in signal transduction. PTPN11/SHP2 is expressed ubiquitously and plays a positive role in cell signaling, leading to cell activation, while PTPN6/SHP1 expression is restricted mainly to hematopoietic and epithelial cells and functions as a negative regulator of signaling events.

Pssm-ID: 350392 [Multi-domain] Cd Length: 251 Bit Score: 254.31 E-value: 7.75e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKKSSDYINANYI-------DGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCII 729
Cdd:cd14544     1 NKGKNRYKNILPFDHTRVILKDRDPNVPGSDYINANYIrnenegpTTDENAKTYIATQGCLENTVSDFWSMVWQENSRVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  730 IMITNLVERGRRKCDMYWPKEG-TETYGIIQVKLVQEIVMATYTIRTFaikNIKVKKKQASERTVYQYHYTNWPDHGVPD 808
Cdd:cd14544    81 VMTTKEVERGKNKCVRYWPDEGmQKQYGPYRVQNVSEHDTTDYTLREL---QVSKLDQGDPIREIWHYQYLSWPDHGVPS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  809 HPLPVLSFV--AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ---SVNVYGFLRHIRQQRNYLVQTEEQ 883
Cdd:cd14544   158 DPGGVLNFLedVNQRQESLPHAGPIVVHCSAGIGRTGTFIVIDMLLDQIKRKGldcDIDIQKTIQMVRSQRSGMVQTEAQ 237

                         250
                  ....*....|....
gi 998470296  884 YVFIHDALLEAIDS 897
Cdd:cd14544   238 YKFIYVAVAQYIET 251

R-PTPc-B

cd14617

catalytic domain of receptor-type tyrosine-protein phosphatase B; Receptor-type ...

661-888

6.30e-76

catalytic domain of receptor-type tyrosine-protein phosphatase B; Receptor-type tyrosine-protein phosphatase B (PTPRB), also known as receptor-type tyrosine-protein phosphatase beta (R-PTP-beta) or vascular endothelial protein tyrosine phosphatase(VE-PTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRB/VE-PTP is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is expressed specifically in vascular endothelial cells and it plays an important role in blood vessel remodeling and angiogenesis.

Pssm-ID: 350465 [Multi-domain] Cd Length: 228 Bit Score: 250.61 E-value: 6.30e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKPIPgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGR 740
Cdd:cd14617     1 NRYNNILPYDSTRVKLSNVD-DDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  741 RKCDMYWPKEGTET-YGIIQVKLVQEIVMATYTIRTFAIKNikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFV-- 817
Cdd:cd14617    80 VKCDHYWPADQDSLyYGDLIVQMLSESVLPEWTIREFKICS---EEQLDAPRLVRHFHYTVWPDHGVPETTQSLIQFVrt 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296  818 AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14617   157 VRDYINRTPGSGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLH 227

R-PTPc-A-E-1

cd14551

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 1; ...

688-888

6.64e-76

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 1; Receptor-type tyrosine-protein phosphatase A (PTPRA) and E (PTPRE) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA and PTPRE share several functions including regulation of Src family kinases and voltage-gated potassium (Kv) channels. They both contain a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the first catalytic PTP domain (repeat 1).

Pssm-ID: 350399 [Multi-domain] Cd Length: 202 Bit Score: 249.83 E-value: 6.64e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14551     1 YINASYIDGYQEKNKFIAAQGPKDETVNDFWRMIWEQGSATIVMVTNLKERKEKKCSQYWPDQGCWTYGNLRVRVEDTVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIV 847
Cdd:cd14551    81 LVDYTTRKFCIQKVNRGIGEKRVRLVTQFHFTSWPDFGVPFTPIGMLKFLKKVKSANPPRAGPIVVHCSAGVGRTGTFIV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 998470296  848 LDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14551   161 IDAMLDMMHAEGKVDVFGFVSRIRQQRSQMVQTDMQYVFIY 201

R-PTPc-U-1

cd14632

catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1; Receptor-type ...

688-894

1.09e-75

catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1; Receptor-type tyrosine-protein phosphatase U (PTPRU), also known as pancreatic carcinoma phosphatase 2 (PCP-2), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRU/PCP-2 is the most distant member of the type IIb subfamily and may have a distinct biological function other than cell-cell aggregation. It localizes to the adherens junctions and directly binds and dephosphorylates beta-catenin, and regulates the balance between signaling and adhesive beta-catenin. It plays an important role in the maintenance of epithelial integrity. PTPRU contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350480 [Multi-domain] Cd Length: 205 Bit Score: 249.20 E-value: 1.09e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEgTETYGIIQVKLVQEIV 767
Cdd:cd14632     1 YINANYIDGYHRSNHFIATQGPKQEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSKYWPDD-SDTYGDIKITLLKTET 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIV 847
Cdd:cd14632    80 LAEYSVRTFALE----RRGYSARHEVKQFHFTSWPEHGVPYHATGLLAFIRRVKASTPPDAGPVVVHCSAGAGRTGCYIV 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 998470296  848 LDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14632   156 LDVMLDMAECEGVVDIYNCVKTLCSRRINMIQTEEQYIFIHDAILEA 202

R-PTPc-K-1

cd14631

catalytic domain of receptor-type tyrosine-protein phosphatase K, repeat 1; Receptor-type ...

673-894

4.19e-73

catalytic domain of receptor-type tyrosine-protein phosphatase K, repeat 1; Receptor-type tyrosine-protein phosphatase K (PTPRK), also known as receptor-type tyrosine-protein phosphatase kappa (RPTP-kappa or PTPkappa), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRK is widely expressed and has been shown to stimulate cell motility and neurite outgrowth. It is required for anti-proliferative and pro-migratory effects of TGF-beta, suggesting a role in regulation, maintenance, and restoration of cell adhesion. It is a potential tumour suppressor in primary central nervous system lymphomas, colorectal cancer, and breast cancer. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350479 [Multi-domain] Cd Length: 218 Bit Score: 242.23 E-value: 4.19e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  673 RVILKPIPgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPkEGT 752
Cdd:cd14631     1 RVILQPVE-DDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  753 ETYGIIQVKLVQEIVMATYTIRTFAIKnikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMI 832
Cdd:cd14631    79 EVYGDFKVTCVEMEPLAEYVVRTFTLE----RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  833 VHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14631   155 VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA 216

PTPc-KIM

cd14547

catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; ...

661-888

1.80e-72

catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; The kinase interaction motif (KIM) family of protein-tyrosine phosphatases (PTPs) includes tyrosine-protein phosphatases non-receptor type 7 (PTPN7) and non-receptor type 5 (PTPN5), and protein-tyrosine phosphatase receptor type R (PTPRR). PTPN7 is also called hematopoietic protein-tyrosine phosphatase (HePTP) while PTPN5 is also called striatal-enriched protein-tyrosine phosphatase (STEP). They belong to the family of classical tyrosine-specific PTPs (EC 3.1.3.48) that catalyze the dephosphorylation of phosphotyrosine peptides. KIM-PTPs are characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. They are highly specific to the MAPKs ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38, over JNK (c-Jun N-terminal kinase); they dephosphorylate these kinases and thereby critically modulate cell proliferation and differentiation.

Pssm-ID: 350395 [Multi-domain] Cd Length: 224 Bit Score: 240.76 E-value: 1.80e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKPIPGQKKSsDYINANYIDGY-HKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERg 739
Cdd:cd14547     1 NRYKTILPNEHSRVCLPSVDDDPLS-SYINANYIRGYdGEEKAYIATQGPLPNTVADFWRMVWQEKTPIIVMITNLTEA- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  740 RRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkkkQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAK 819
Cdd:cd14547    79 KEKCAQYWPEEENETYGDFEVTVQSVKETDGYTVRKLTLKY------GGEKRYLKHYWYTSWPDHKTPEAAQPLLSLVQE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296  820 --SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14547   153 veEARQTEPHRGPIVVHCSAGIGRTGCFIATSIGCQQLREEGVVDVLGIVCQLRLDRGGMVQTAEQYEFVH 223

R-PTPc-V

cd14618

catalytic domain of receptor-type tyrosine-protein phosphatase V; Receptor-type ...

661-892

2.11e-72

catalytic domain of receptor-type tyrosine-protein phosphatase V; Receptor-type tyrosine-protein phosphatase V (PTPRV or R-PTP-V), also known as embryonic stem cell protein-tyrosine phosphatase (ES cell phosphatase) or osteotesticular protein-tyrosine phosphatase (OST-PTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRV is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. In rodents, it may play a role in the maintenance of pluripotency and may function in signaling pathways during bone remodeling. It is the only PTP whose function has been lost between rodent and human. The human OST-PTP gene is a pseudogene.

Pssm-ID: 350466 [Multi-domain] Cd Length: 230 Bit Score: 241.00 E-value: 2.11e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKPIPGQKKSsDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGR 740
Cdd:cd14618     1 NRYPHVLPYDHSRVRLSQLGGEPHS-DYINANFIPGYTSPQEFIATQGPLKKTIEDFWRLVWEQQVCNIIMLTVGMENGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  741 RKCDMYWPKEGTE-TYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFV-- 817
Cdd:cd14618    80 VLCDHYWPSESTPvSYGHITVHLLAQSSEDEWTRREFKLWHEDLRK----ERRVKHLHYTAWPDHGIPESTSSLMAFRel 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998470296  818 AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:cd14618   156 VREHVQATKGKGPTLVHCSAGVGRSGTFIALDRLLRQLKEEKVVDVFNTVYILRMHRYLMIQTLSQYIFLHSCIL 230

PTP_fungal

cd18533

fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae ...

688-889

3.47e-72

fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae protein-tyrosine phosphatases 1 (PTP1) and 2 (PTP2), Schizosaccharomyces pombe PTP1, PTP2, and PTP3, and similar fungal proteins. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. PTP2, together with PTP3, is the major phosphatase that dephosphorylates and inactivates the MAP kinase HOG1 and also modulates its subcellular localization.

Pssm-ID: 350509 [Multi-domain] Cd Length: 212 Bit Score: 239.46 E-value: 3.47e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYID-GYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWP-KEGTETYGIIQVKLVQ- 764
Cdd:cd18533     1 YINASYITlPGTSSKRYIATQGPLPATIGDFWKMIWQNNVGVIVMLTPLVENGREKCDQYWPsGEYEGEYGDLTVELVSe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  765 -EIVMATYTIRTFaikniKVKKKQASERTVYQYHYTNWPDHGVPDHPLPV--LSFVAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd18533    81 eENDDGGFIVREF-----ELSKEDGKVKKVYHIQYKSWPDFGVPDSPEDLltLIKLKRELNDSASLDPPIIVHCSAGVGR 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296  842 TGTYIVLDAMLRQM----RQRQSVN-----VYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd18533   156 TGTFIALDSLLDELkrglSDSQDLEdsedpVYEIVNQLRKQRMSMVQTLRQYIFLYD 212

R-PTP-LAR-2

cd14554

PTP-like domain of the LAR family receptor-type tyrosine-protein phosphatases, repeat 2; The ...

657-892

1.08e-71

PTP-like domain of the LAR family receptor-type tyrosine-protein phosphatases, repeat 2; The LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs) include three vertebrate members: LAR (or PTPRF), R-PTP-delta (or PTPRD), and R-PTP-sigma (or PTPRS). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules; they bind to distinct synaptic membrane proteins and are physiologically responsible for mediating presynaptic development by shaping various synaptic adhesion pathways. They play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. LAR-RPTPs contain an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2).

Pssm-ID: 350402 [Multi-domain] Cd Length: 238 Bit Score: 239.35 E-value: 1.08e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:cd14554     6 NKFKNRLVNILPYESTRVCLQPIRGVE-GSDYINASFIDGYRQRGAYIATQGPLAETTEDFWRMLWEHNSTIIVMLTKLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  737 ERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIkvkkKQASERTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14554    85 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296  817 VAK--SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:cd14554   161 IGQvhKTKEQFGQEGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDVFQTVKLLRTQRPAMVQTEDQYQFCYRAAL 238

R-PTPc-O

cd14614

catalytic domain of receptor-type tyrosine-protein phosphatase O; Receptor-type ...

646-888

1.66e-67

catalytic domain of receptor-type tyrosine-protein phosphatase O; Receptor-type tyrosine-protein phosphatase O (PTPRO or R-PTP-O), also known as glomerular epithelial protein 1 or protein tyrosine phosphatase U2 (PTP-U2), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRO is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is essential for sustaining the structure and function of foot processes by regulating tyrosine phosphorylation of podocyte proteins. It has been identified as a synaptic cell adhesion molecule (CAM) that serves as a potent initiator of synapse formation. It is also a tumor suppressor in several types of cancer, such as hepatocellular carcinoma, lung cancer, and breast cancer.

Pssm-ID: 350462 [Multi-domain] Cd Length: 245 Bit Score: 227.46 E-value: 1.66e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  646 DLTSSYSQLNENKPKNRYINIVAYDHTRVILKPIpGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQR 725
Cdd:cd14614     1 DIPHFAADLPVNRCKNRYTNILPYDFSRVKLVSM-HEEEGSDYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  726 VCIIIMITNLVERGRRKCDMYWP-KEGTETYGIIQVKLVQEIVMATYTIRTFaikniKVKKKQASERtVYQYHYTNWPDH 804
Cdd:cd14614    80 SQIIVMLTQCNEKRRVKCDHYWPfTEEPVAYGDITVEMLSEEEQPDWAIREF-----RVSYADEVQD-VMHFNYTAWPDH 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  805 GVP--DHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEE 882
Cdd:cd14614   154 GVPtaNAAESILQFVQMVRQQAVKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEE 233


                  ....*.
gi 998470296  883 QYVFIH 888
Cdd:cd14614   234 QYIFIH 239

R-PTPc-C-1

cd14557

catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1; Receptor-type ...

688-888

2.90e-67

catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1; Receptor-type tyrosine-protein phosphatase C (PTPRC), also known as CD45, leukocyte common antigen (LCA) or GP180, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRC/CD45 is found in all nucleated hematopoietic cells and is an essential regulator of T- and B-cell antigen receptor signaling. It controls immune response, both positively and negatively, by dephosphorylating a number of signaling molecules such as the Src family kinases, the CD3zeta chain of TCY, and ZAP-70 kinase. Mutations in the human PTPRC/CD45 gene are associated with severe combined immunodeficiency (SCID) and multiple sclerosis. PTPRC/CD45 contains an extracellular receptor-like region with fibronectin type III (FN3) repeats, a short transmembrane segment, and a cytoplasmic region comprising of a membrane proximal catalytically active PTP domain (repeat 1 or D1) and a membrane distal catalytically impaired PTP-like domain (repeat 2, or D2). This model represents repeat 1.

Pssm-ID: 350405 [Multi-domain] Cd Length: 201 Bit Score: 225.09 E-value: 2.90e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWP--KEGTETYGIIQVKLVQE 765
Cdd:cd14557     1 YINASYIDGFKEPRKYIAAQGPKDETVDDFWRMIWEQKSTVIVMVTRCEEGNRNKCAQYWPsmEEGSRAFGDVVVKINEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  766 IVMATYTIRTFAIKNikvKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTY 845
Cdd:cd14557    81 KICPDYIIRKLNINN---KKEKGSGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFNNFFSGPIVVHCSAGVGRTGTY 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14557   158 IGIDAMLEGLEAEGRVDVYGYVVKLRRQRCLMVQVEAQYILIH 200

PTPc-N11

cd14605

catalytic domain of tyrosine-protein phosphatase non-receptor type 11; Tyrosine-protein ...

656-897

5.35e-65

catalytic domain of tyrosine-protein phosphatase non-receptor type 11; Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), also called SH2 domain-containing tyrosine phosphatase 2 (SHP-2 or SHP2), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN11 promotes the activation of the RAS/Mitogen-Activated Protein Kinases (MAPK) Extracellular-Regulated Kinases 1/2 (ERK1/2) pathway, a canonical signaling cascade that plays key roles in various cellular processes, including proliferation, survival, differentiation, migration, or metabolism. It also regulates the phosphoinositide 3-kinase (PI3K)/AKT pathway, a fundamental cascade that functions in cell survival, proliferation, migration, morphogenesis, and metabolism. PTPN11 dysregulation is associated with several developmental diseases and malignancies, such as Noonan syndrome and juvenile myelomonocytic leukemia. It contains two tandem SH2 domains, a catalytic PTP domain, and a C-terminal tail with regulatory properties.

Pssm-ID: 350453 [Multi-domain] Cd Length: 253 Bit Score: 220.66 E-value: 5.35e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  656 ENKPKNRYINIVAYDHTRVILKPIPGQKKSSDYINANYIDGYHKS--------RAFIGTQGPLPATFDDYWRMVWEQRVC 727
Cdd:cd14605     1 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETkcnnskpkKSYIATQGCLQNTVNDFWRMVFQENSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  728 IIIMITNLVERGRRKCDMYWPKE-GTETYGIIQVKLVQEIVMATYTIRTFAIKNIkvkKKQASERTVYQYHYTNWPDHGV 806
Cdd:cd14605    81 VIVMTTKEVERGKSKCVKYWPDEyALKEYGVMRVRNVKESAAHDYILRELKLSKV---GQGNTERTVWQYHFRTWPDHGV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  807 PDHPLPVLSFV--AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ---SVNVYGFLRHIRQQRNYLVQTE 881
Cdd:cd14605   158 PSDPGGVLDFLeeVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTE 237

                         250
                  ....*....|....*.
gi 998470296  882 EQYVFIHDALLEAIDS 897
Cdd:cd14605   238 AQYRFIYMAVQHYIET 253

R-PTP-N2

cd14610

PTP-like domain of receptor-type tyrosine-protein phosphatase N2; Receptor-type ...

634-897

1.47e-63

PTP-like domain of receptor-type tyrosine-protein phosphatase N2; Receptor-type tyrosine-protein phosphatase N2 (PTPRN2 or R-PTP-N2), also called islet cell autoantigen-related protein (IAR), ICAAR, phogrin, or IA-2beta, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). It consists of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. It is mainly expressed in neuropeptidergic neurons and peptide-secreting endocrine cells, including insulin-producing pancreatic beta-cells. It may function as a phosphatidylinositol phosphatase to regulate insulin secretion. It is also required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain.

Pssm-ID: 350458 [Multi-domain] Cd Length: 283 Bit Score: 218.00 E-value: 1.47e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  634 REYETF-QHCTDPDlTSSYSQLNENKPKNRYINIVAYDHTRVILKpIPGQKKSSDYINANYI-DGYHKSRAFIGTQGPLP 711
Cdd:cd14610    21 KEWEALcAYQAEPN-ATNVAQREENVQKNRSLAVLPYDHSRIILK-AENSHSHSDYINASPImDHDPRNPAYIATQGPLP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  712 ATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQE-IVMATYTIRTFAIKNIKVKKKqase 790
Cdd:cd14610    99 ATVADFWQMVWESGCVVIVMLTPLAENGVKQCYHYWPDEGSNLYHIYEVNLVSEhIWCEDFLVRSFYLKNLQTNET---- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  791 RTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQM-RQRQSVNVYGFLRH 869
Cdd:cd14610   175 RTVTQFHFLSWNDQGVPASTRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYILIDMVLNKMaKGAKEIDIAATLEH 254

                         250       260
                  ....*....|....*....|....*...
gi 998470296  870 IRQQRNYLVQTEEQYVFIHDALLEAIDS 897
Cdd:cd14610   255 LRDQRPGMVQTKEQFEFALTAVAEEVNA 282

PTPc-N6

cd14606

catalytic domain of tyrosine-protein phosphatase non-receptor type 6; Tyrosine-protein ...

653-897

4.04e-63

catalytic domain of tyrosine-protein phosphatase non-receptor type 6; Tyrosine-protein phosphatase non-receptor type 6 (PTPN6), also called SH2 domain-containing protein-tyrosine phosphatase 1 (SHP1 or SHP-1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN6 expression is restricted mainly to hematopoietic and epithelial cells. It is an important regulator of hematopoietic cells, downregulating pathways that promote cell growth, survival, adhesion, and activation. It regulates glucose homeostasis by modulating insulin signalling in the liver and muscle, and it also negatively regulates bone resorption, affecting both the formation and the function of osteoclasts. PTPN6 contains two tandem SH2 domains, a catalytic PTP domain, and a C-terminal tail with regulatory properties.

Pssm-ID: 350454 [Multi-domain] Cd Length: 266 Bit Score: 215.90 E-value: 4.04e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  653 QLNENKPKNRYINIVAYDHTRVILK----PIPGqkksSDYINANYIDGY-----HKSRAFIGTQGPLPATFDDYWRMVWE 723
Cdd:cd14606    14 QRPENKSKNRYKNILPFDHSRVILQgrdsNIPG----SDYINANYVKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  724 QRVCIIIMITNLVERGRRKCDMYWPKEGTE-TYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKKqasERTVYQYHYTNWP 802
Cdd:cd14606    90 ENSRVIVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGEL---IREIWHYQYLSWP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  803 DHGVPDHPLPVLSFVAKSSAANP--PAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ---SVNVYGFLRHIRQQRNYL 877
Cdd:cd14606   167 DHGVPSEPGGVLSFLDQINQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGM 246

                         250       260
                  ....*....|....*....|
gi 998470296  878 VQTEEQYVFIHDALLEAIDS 897
Cdd:cd14606   247 VQTEAQYKFIYVAIAQFIET 266

R-PTP-D-2

cd14628

PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2; Receptor-type ...

657-899

1.89e-62

PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2; Receptor-type tyrosine-protein phosphatase-like D (PTPRD), also known as receptor-type tyrosine-protein phosphatase delta (R-PTP-delta), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules that play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. PTPRD is involved in pre-synaptic differentiation through interaction with SLITRK2. It contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350476 [Multi-domain] Cd Length: 292 Bit Score: 214.98 E-value: 1.89e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:cd14628    52 NKFKNRLVNIMPYESTRVCLQPIRGVE-GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLR 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  737 ERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14628   131 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDF 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  817 VAKSSAANPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14628   207 IGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEY 286


                  ....*
gi 998470296  895 IDSGD 899
Cdd:cd14628   287 LGSFD 291

R-PTP-S-2

cd14627

PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2; Receptor-type ...

657-897

5.63e-62

PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2; Receptor-type tyrosine-protein phosphatase S (PTPRS), also known as receptor-type tyrosine-protein phosphatase sigma (R-PTP-sigma), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRS is a receptor for glycosaminoglycans, including heparan sulfate proteoglycan and neural chondroitin sulfate proteoglycans (CSPGs), which present a barrier to axon regeneration. It also plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. PTPRS contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350475 [Multi-domain] Cd Length: 290 Bit Score: 213.44 E-value: 5.63e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:cd14627    53 NKFKNRLVNIMPYETTRVCLQPIRGVE-GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  737 ERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14627   132 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDF 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  817 VAKSSAANPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14627   208 IGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 287


                  ...
gi 998470296  895 IDS 897
Cdd:cd14627   288 LGS 290

PTPc-N22_18_12

cd14542

catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; ...

688-888

5.11e-61

catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), type 18 (PTPN18) and type 12 (PTPN12) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. TPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling.

Pssm-ID: 350390 [Multi-domain] Cd Length: 202 Bit Score: 207.28 E-value: 5.11e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTE--TYGIIQVKLV-Q 764
Cdd:cd14542     1 YINANFIKGVSGSKAYIATQGPLPNTVLDFWRMIWEYNVQVIVMACREFEMGKKKCERYWPEEGEEqlQFGPFKISLEkE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  765 EIVMATYTIRTFAIknikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGT 844
Cdd:cd14542    81 KRVGPDFLIRTLKV------TFQKESRTVYQFHYTAWPDHGVPSSVDPILDLVRLVRDYQGSEDVPICVHCSAGCGRTGT 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 998470296  845 YIVLD----AMLRQMRQrQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14542   155 ICAIDyvwnLLKTGKIP-EEFSLFDLVREMRKQRPAMVQTKEQYELVY 201

R-PTP-N

cd14609

PTP-like domain of receptor-type tyrosine-protein phosphatase N; Receptor-type ...

648-897

7.99e-61

PTP-like domain of receptor-type tyrosine-protein phosphatase N; Receptor-type tyrosine-protein phosphatase-like N (PTPRN or R-PTP-N), also called islet cell antigen 512 (ICA512) or PTP IA-2, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). It consists of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. PTPRN is located in secretory granules of neuroendocrine cells and is involved in the generation, cargo storage, traffic, exocytosis and recycling of insulin secretory granules, as well as in beta-cell proliferation. It is a major autoantigen in type 1 diabetes and is involved in the regulation of insulin secretion.

Pssm-ID: 350457 [Multi-domain] Cd Length: 281 Bit Score: 209.89 E-value: 7.99e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  648 TSSYSQLNENKPKNRYINIVAYDHTRVILKpIPGQKKSSDYINAN-YIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRV 726
Cdd:cd14609    33 TCSTAQGEANVKKNRNPDFVPYDHARIKLK-AESNPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWENGC 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  727 CIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQE-IVMATYTIRTFAIKNIKVKKKqaseRTVYQYHYTNWPDHG 805
Cdd:cd14609   112 TVIVMLTPLVEDGVKQCDRYWPDEGSSLYHIYEVNLVSEhIWCEDFLVRSFYLKNVQTQET----RTLTQFHFLSWPAEG 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  806 VPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQM-RQRQSVNVYGFLRHIRQQRNYLVQTEEQY 884
Cdd:cd14609   188 IPSSTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGMVRTKDQF 267

                         250
                  ....*....|...
gi 998470296  885 VFIHDALLEAIDS 897
Cdd:cd14609   268 EFALTAVAEEVNA 280

PTPc-N18

cd14603

catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein ...

656-893

3.30e-60

catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein phosphatase non-receptor type 18 (PTPN18), also called brain-derived phosphatase, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. The N-terminal catalytic PTP domain of PTPN18 blocks lysosomal routing and delays the degradation of HER2 by dephosphorylation, and its C-terminal PEST domain promotes K48-linked HER2 ubiquitination and its destruction via the proteasome pathway.

Pssm-ID: 350451 [Multi-domain] Cd Length: 266 Bit Score: 207.76 E-value: 3.30e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  656 ENKPKNRYINIVAYDHTRVILKPIPgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNL 735
Cdd:cd14603    29 ENVKKNRYKDILPYDQTRVILSLLQ-EEGHSDYINANFIKGVDGSRAYIATQGPLSHTVLDFWRMIWQYGVKVILMACRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  736 VERGRRKCDMYWP-KEGTETYGIIQVKLVQEIVMATYTIrtfaIKNIKVKKKQASeRTVYQYHYTNWPDHGVPDHPLPVL 814
Cdd:cd14603   108 IEMGKKKCERYWAqEQEPLQTGPFTITLVKEKRLNEEVI----LRTLKVTFQKES-RSVSHFQYMAWPDHGIPDSPDCML 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  815 SFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDaMLRQMRQRQSV----NVYGFLRHIRQQRNYLVQTEEQYVFIHDA 890
Cdd:cd14603   183 AMIELARRLQGSGPEPLCVHCSAGCGRTGVICTVD-YVRQLLLTQRIppdfSIFDVVLEMRKQRPAAVQTEEQYEFLYHT 261


                  ...
gi 998470296  891 LLE 893
Cdd:cd14603   262 VAQ 264

R-PTP-F-2

cd14629

PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2; Receptor-type ...

657-897

5.10e-60

PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2; Receptor-type tyrosine-protein phosphatase F (PTPRF), also known as leukocyte common antigen related (LAR), is the prototypical member of the LAR family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRF/LAR plays a role for LAR in cadherin complexes where it associates with and dephosphorylates beta-catenin, a pathway which may be critical for cadherin complex stability and cell-cell association. It also regulates focal adhesions through cyclin-dependent kinase-1 and is involved in axon guidance in the developing nervous system. It also functions in regulating insulin signaling. PTPRF contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350477 [Multi-domain] Cd Length: 291 Bit Score: 208.04 E-value: 5.10e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  657 NKPKNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLV 736
Cdd:cd14629    53 NKFKNRLVNIMPYELTRVCLQPIRGVE-GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  737 ERGRRKCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14629   132 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD----ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDF 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  817 VAKSSAANPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14629   208 IGQVHKTKEQFGqdGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 287


                  ...
gi 998470296  895 IDS 897
Cdd:cd14629   288 LGS 290

PTPc-N20_13

cd14538

catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; ...

688-895

2.05e-59

catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) and type 13 (PTPN13, also known as PTPL1) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Human PTPN13 is an important regulator of tumor aggressiveness.

Pssm-ID: 350386 [Multi-domain] Cd Length: 207 Bit Score: 202.99 E-value: 2.05e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYI------DGYHksraFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTET---YGII 758
Cdd:cd14538     1 YINASHIripvggDTYH----YIACQGPLPNTTGDFWQMVWEQKSEVIAMVTQDVEGGKVKCHRYWPDSLNKPlicGGRL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  759 QVKLVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFV--AKSSAANppaaGPMIVHCS 836
Cdd:cd14538    77 EVSLEKYQSLQDFVIRRISLRDKETGE----VHHITHLNFTTWPDHGTPQSADPLLRFIryMRRIHNS----GPIVVHCS 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296  837 AGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd14538   149 AGIGRTGVLITIDVALGLIERDLPFDIQDIVKDLREQRQGMIQTKDQYIFCYKACLEVL 207

R-PTPc-Q

cd14616

catalytic domain of receptor-type tyrosine-protein phosphatase Q; Receptor-type ...

661-888

3.40e-59

catalytic domain of receptor-type tyrosine-protein phosphatase Q; Receptor-type tyrosine-protein phosphatase Q (PTPRQ or R-PTP-Q), also called phosphatidylinositol phosphatase PTPRQ, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRQ is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats (18 in PTPRQ) and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It displays low tyrosine-protein phosphatase activity; rather, it functions as a phosphatidylinositol phosphatase required for auditory processes. It regulates the levels of phosphatidylinositol 4,5-bisphosphate (PIP2) in the basal region of hair bundles. It can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates.

Pssm-ID: 350464 [Multi-domain] Cd Length: 224 Bit Score: 203.21 E-value: 3.40e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  661 NRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGR 740
Cdd:cd14616     1 NRFPNIKPYNNNRVKLIADAGVP-GSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTIVMLTQCFEKGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  741 RKCDMYWPKEG--TETYGIIQVKLVQEIVMATYTIRTFAIKnikvkkKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVA 818
Cdd:cd14616    80 IRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIE------RHGDYMMVRQCNFTSWPEHGVPESSAPLIHFVK 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  819 KSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14616   154 LVRASRAHDNTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLH 223

PTPc-N1_2

cd14545

catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2; ...

660-886

6.42e-59

catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2; Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) type 2 (PTPN2) belong to the family of classical tyrosine-specific protein tyrosine phosphatases, (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1 (or PTP-1B) is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor. PTPN2 (or TCPTP), a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner.

Pssm-ID: 350393 [Multi-domain] Cd Length: 231 Bit Score: 202.62 E-value: 6.42e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  660 KNRYINIVAYDHTRVILKPipgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERG 739
Cdd:cd14545     1 LNRYRDRDPYDHDRSRVKL---KQGDNDYINASLVEVEEAKRSYILTQGPLPNTSGHFWQMVWEQNSKAVIMLNKLMEKG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  740 RRKCDMYWPKEGTETYGI----IQVKLVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLS 815
Cdd:cd14545    78 QIKCAQYWPQGEGNAMIFedtgLKVTLLSEEDKSYYTVRTLELENLKTQE----TREVLHFHYTTWPDFGVPESPAAFLN 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998470296  816 FVAK--SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ--SVNVYGFLRHIRQQRNYLVQTEEQYVF 886
Cdd:cd14545   154 FLQKvrESGSLSSDVGPPVVHCSAGIGRSGTFCLVDTCLVLIEKGNpsSVDVKKVLLEMRKYRMGLIQTPDQLRF 228

PTPc-N7

cd14612

catalytic domain of tyrosine-protein phosphatase non-receptor type 7; Tyrosine-protein ...

660-891

6.95e-59

catalytic domain of tyrosine-protein phosphatase non-receptor type 7; Tyrosine-protein phosphatase non-receptor type 7 (PTPN7), also called hematopoietic protein-tyrosine phosphatase (HePTP) or LC-PTP. belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN7/HePTP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. PTPN7/HePTP is found exclusively in the white blood cells in bone marrow, thymus, spleen, lymph nodes and all myeloid and lymphoid cell lines. It negatively regulates T-cell activation and proliferation, and is often dysregulated in the preleukemic disorder myelodysplastic syndrome, as well as in acute myelogenous leukemia.

Pssm-ID: 350460 [Multi-domain] Cd Length: 247 Bit Score: 203.14 E-value: 6.95e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  660 KNRYINIVAYDHTRVILKPIPGQKKSSDYINANYIDGYH-KSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVER 738
Cdd:cd14612    18 KDRYKTILPNPQSRVCLRRAGSQEEEGSYINANYIRGYDgKEKAYIATQGPMLNTVSDFWEMVWQEECPIIVMITKLKEK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  739 gRRKCDMYWPkEGTETYG--IIQVKLVQEIvmATYTIRTFAIKNikvkkkQASERTVYQYHYTNWPDHGVPDHPLPVLSF 816
Cdd:cd14612    98 -KEKCVHYWP-EKEGTYGrfEIRVQDMKEC--DGYTIRDLTIQL------EEESRSVKHYWFSSWPDHQTPESAGPLLRL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  817 VAK-----SSAANPpaaGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDAL 891
Cdd:cd14612   168 VAEveesrQTAASP---GPIVVHCSAGIGRTGCFIATSIGCQQLKDTGKVDILGIVCQLRLDRGGMIQTSEQYQFLHHTL 244

PTPc-N22

cd14602

catalytic domain of tyrosine-protein phosphatase non-receptor type 22; Tyrosine-protein ...

660-893

8.32e-59

catalytic domain of tyrosine-protein phosphatase non-receptor type 22; Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), also called lymphoid phosphatase (LyP), PEST-domain phosphatase (PEP), or hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. Mutations in the PTPN22 gene are associated with multiple connective tissue and autoimmune diseases including type 1 diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus. PTPN22 contains an N-terminal catalytic PTP domain and four proline-rich regions at the C-terminus.

Pssm-ID: 350450 [Multi-domain] Cd Length: 234 Bit Score: 202.38 E-value: 8.32e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  660 KNRYINIVAYDHTRVILKPIPGQKkSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERG 739
Cdd:cd14602     1 KNRYKDILPYDHSRVELSLITSDE-DSDYINANFIKGVYGPRAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEFEMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  740 RRKCDMYWPKEGTET--YGIIQVKLVQEIVMATYTIRTfaiknIKVKKKQASeRTVYQYHYTNWPDHGVPDHPLPVLSFV 817
Cdd:cd14602    80 KKKCERYWAEPGEMQleFGPFSVTCEAEKRKSDYIIRT-----LKVKFNSET-RTIYQFHYKNWPDHDVPSSIDPILELI 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296  818 AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQR---QSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14602   154 WDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIQEMRTQRPSLVQTKEQYELVYNAVIE 232

PTPc-N12

cd14604

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein ...

656-891

1.70e-58

Pssm-ID: 350452 [Multi-domain] Cd Length: 297 Bit Score: 204.01 E-value: 1.70e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  656 ENKPKNRYINIVAYDHTRVILKpIPGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNL 735
Cdd:cd14604    56 ENVKKNRYKDILPFDHSRVKLT-LKTSSQDSDYINANFIKGVYGPKAYIATQGPLANTVIDFWRMIWEYNVAIIVMACRE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  736 VERGRRKCDMYWPKEGTE--TYGIIQVKLVQEIVMATYTIRTFAIKNikvkkkQASERTVYQYHYTNWPDHGVP---DHP 810
Cdd:cd14604   135 FEMGRKKCERYWPLYGEEpmTFGPFRISCEAEQARTDYFIRTLLLEF------QNETRRLYQFHYVNWPDHDVPssfDSI 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  811 LPVLSFVAKSSAANPPaagPMIVHCSAGVGRTGTYIVLD---AMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFI 887
Cdd:cd14604   209 LDMISLMRKYQEHEDV---PICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELV 285


                  ....
gi 998470296  888 HDAL 891
Cdd:cd14604   286 HRAI 289

PTPc-N3_4

cd14541

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

687-894

2.07e-58

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) and type 4 (PTPN4) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 and PTPN4 are large modular proteins containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN4 functions in TCR cell signaling, apoptosis, cerebellar synaptic plasticity, and innate immune responses.

Pssm-ID: 350389 [Multi-domain] Cd Length: 212 Bit Score: 200.25 E-value: 2.07e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  687 DYINANYID----GYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG-TETYGIIQVK 761
Cdd:cd14541     1 DYINANYVNmeipGSGIVNRYIAAQGPLPNTCADFWQMVWEQKSTLIVMLTTLVERGRVKCHQYWPDLGeTMQFGNLQIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  762 LVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14541    81 CVSEEVTPSFAFREFILTNTNTGE----ERHITQMQYLAWPDHGVPDDSSDFLDFVKRVRQNRVGMVEPTVVHCSAGIGR 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEA 894
Cdd:cd14541   157 TGVLITMETAMCLIEANEPVYPLDIVRTMRDQRAMLIQTPSQYRFVCEAILRV 209

PTPc-N5

cd14613

catalytic domain of tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein ...

660-891

6.81e-58

catalytic domain of tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein phosphatase non-receptor type 5 (PTPN5), also called striatum-enriched protein-tyrosine phosphatase (STEP) or neural-specific PTP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN5/STEP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. It is a CNS-enriched protein that regulates key signaling proteins required for synaptic strengthening, as well as NMDA and AMPA receptor trafficking. PTPN5 is implicated in multiple neurologic and neuropsychiatric disorders, such as Alzheimer's disease, Parkinson's disease, schizophrenia, and fragile X syndrome.

Pssm-ID: 350461 [Multi-domain] Cd Length: 258 Bit Score: 200.47 E-value: 6.81e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  660 KNRYINIVAYDHTRVILKPIPGQKKSSDYINANYIDGY-HKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVER 738
Cdd:cd14613    28 KNRYKTILPNPHSRVCLTSPDQDDPLSSYINANYIRGYgGEEKVYIATQGPTVNTVGDFWRMVWQERSPIIVMITNIEEM 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  739 GRrKCDMYWPKEGTeTYGIIQVKLVQEIVMATYTIRTFAIKnikvkkKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVA 818
Cdd:cd14613   108 NE-KCTEYWPEEQV-TYEGIEITVKQVIHADDYRLRLITLK------SGGEERGLKHYWYTSWPDQKTPDNAPPLLQLVQ 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296  819 KSSAAN---PPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDAL 891
Cdd:cd14613   180 EVEEARqqaEPNCGPVIVHCSAGIGRTGCFIATSICCKQLRNEGVVDILRTTCQLRLDRGGMIQTCEQYQFVHHVL 255

R-PTPc-A-2

cd14623

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2; Receptor-type ...

662-893

1.06e-57

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2; Receptor-type tyrosine-protein phosphatase A (PTPRA), also known as receptor-type tyrosine-protein phosphatase alpha (R-PTP-alpha), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA is a positive regulator of Src and Src family kinases via dephosphorylation of the Src-inhibitory tyrosine 527. Thus, it affects transformation and tumorigenesis, inhibition of proliferation, cell cycle arrest, integrin signaling, neuronal differentiation and outgrowth, and ion channel activity. It is also involved in interleukin-1 signaling in fibroblasts through its interaction with the focal adhesion targeting domain of focal adhesion kinase. PTPRA comprises a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350471 [Multi-domain] Cd Length: 228 Bit Score: 199.12 E-value: 1.06e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  662 RYINIVAYDHTRVILkPIPGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRR 741
Cdd:cd14623     1 RVLQIIPYEFNRVII-PVKRGEENTDYVNASFIDGYRQKDSYIASQGPLQHTIEDFWRMIWEWKSCSIVMLTELEERGQE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  742 KCDMYWPKEGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSS 821
Cdd:cd14623    80 KCAQYWPSDGSVSYGDITIELKKEEECESYTVRDLLVTNTRENK----SRQIRQFHFHGWPEVGIPSDGKGMINIIAAVQ 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 998470296  822 AANPPAAG-PMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14623   156 KQQQQSGNhPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE 228

PTPc-N1

cd14608

catalytic domain of tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein ...

646-902

4.15e-57

catalytic domain of tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 1 (PTPN1), also called protein-tyrosine phosphatase 1B (PTP-1B), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1/PTP-1B is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It contains an N-terminal catalytic PTP domain, followed by two tandem proline-rich motifs that mediate interaction with SH3-domain-containing proteins, and a small hydrophobic stretch that localizes the enzyme to the endoplasmic reticulum (ER). It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor.

Pssm-ID: 350456 [Multi-domain] Cd Length: 277 Bit Score: 199.10 E-value: 4.15e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  646 DLTSSYSQLNENKPKNRYINIVAYDHTRVILkpipgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQR 725
Cdd:cd14608    14 DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL-----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  726 VCIIIMITNLVERGRRKCDMYWP-KEGTETY---GIIQVKLVQEIVMATYTIRTFAIKNIKVKKKqaseRTVYQYHYTNW 801
Cdd:cd14608    89 SRGVVMLNRVMEKGSLKCAQYWPqKEEKEMIfedTNLKLTLISEDIKSYYTVRQLELENLTTQET----REILHFHYTTW 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  802 PDHGVPDHPLPVLSFVAK--SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ---SVNVYGFLRHIRQQRNY 876
Cdd:cd14608   165 PDFGVPESPASFLNFLFKvrESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMG 244

                         250       260
                  ....*....|....*....|....*...
gi 998470296  877 LVQTEEQYVFIHDALLEAID--SGDTEV 902
Cdd:cd14608   245 LIQTADQLRFSYLAVIEGAKfiMGDSSV 272

R-PTPc-A-E-2

cd14552

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 2; ...

688-891

8.41e-57

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 2; Receptor-type tyrosine-protein phosphatase A (PTPRA) and E (PTPRE) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA and PTPRE share several functions including regulation of Src family kinases and voltage-gated potassium (Kv) channels. They both contain a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350400 [Multi-domain] Cd Length: 202 Bit Score: 195.18 E-value: 8.41e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14552     1 YINASFIDGYRQKDAYIATQGPLDHTVEDFWRMIWEWKSCSIVMLTEIKERSQNKCAQYWPEDGSVSSGDITVELKDQTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAA-GPMIVHCSAGVGRTGTYI 846
Cdd:cd14552    81 YEDYTLRDFLVTK----GKGGSTRTVRQFHFHGWPEVGIPDNGKGMIDLIAAVQKQQQQSGnHPITVHCSAGAGRTGTFC 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 998470296  847 VLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDAL 891
Cdd:cd14552   157 ALSTVLERVKAEGVLDVFQVVKSLRLQRPHMVQTLEQYEFCYKVV 201

R-PTPc-R

cd14611

catalytic domain of receptor-type tyrosine-protein phosphatase R; Receptor-type ...

660-888

2.71e-56

catalytic domain of receptor-type tyrosine-protein phosphatase R; Receptor-type tyrosine-protein phosphatase-like R (PTPRR or R-PTP-R), also called protein-tyrosine phosphatase PCPTP1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRR is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. The human and mouse PTPRR gene produces multiple neuronal protein isoforms of varying sizes (in human, PTPPBS-alpha, beta, gamma and delta). All isoforms contain the KIM motif and the catalytic PTP domain. PTPRR-deficient mice show significant defects in fine motor coordination and balance skills that are reminiscent of a mild ataxia.

Pssm-ID: 350459 [Multi-domain] Cd Length: 226 Bit Score: 194.75 E-value: 2.71e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  660 KNRYINIVAYDHTRVILKPIPGQKKSSDYINANYIDGYH-KSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVER 738
Cdd:cd14611     2 KNRYKTILPNPHSRVCLKPKNSNDSLSTYINANYIRGYGgKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  739 GRrKCDMYWPkEGTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkkkQASERTVYQYHYTNWPDHGVPDHPLPVLSFV- 817
Cdd:cd14611    82 NE-KCVLYWP-EKRGIYGKVEVLVNSVKECDNYTIRNLTLKQ------GSQSRSVKHYWYTSWPDHKTPDSAQPLLQLMl 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  818 -AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14611   154 dVEEDRLASPGRGPVVVHCSAGIGRTGCFIATTIGCQQLKEEGVVDVLSIVCQLRVDRGGMVQTSEQYEFVH 225

R-PTP-N-N2

cd14546

PTP-like domain of receptor-type tyrosine-protein phosphatase-like N and N2; Receptor-type ...

688-896

3.25e-56

PTP-like domain of receptor-type tyrosine-protein phosphatase-like N and N2; Receptor-type tyrosine-protein phosphatase-like N (PTPRN) and N2 (PTPRN2) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). They consist of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. They are mainly expressed in neuropeptidergic neurons and peptide-secreting endocrine cells, including insulin-producing pancreatic beta-cells, and are involved in involved in the generation, cargo storage, traffic, exocytosis and recycling of insulin secretory granules, as well as in beta-cell proliferation. They also are major autoantigens in type 1 diabetes and are involved in the regulation of insulin secretion.

Pssm-ID: 350394 [Multi-domain] Cd Length: 208 Bit Score: 193.81 E-value: 3.25e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYI-DGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQE- 765
Cdd:cd14546     1 YINASTIyDHDPRNPAYIATQGPLPHTIADFWQMIWEQGCVVIVMLTRLQENGVKQCARYWPEEGSEVYHIYEVHLVSEh 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  766 IVMATYTIRTFAIKNIkvkkkQASE-RTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGRTGT 844
Cdd:cd14546    81 IWCDDYLVRSFYLKNL-----QTSEtRTVTQFHFLSWPDEGIPASAKPLLEFRRKVNKSYRGRSCPIVVHCSDGAGRTGT 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 998470296  845 YIVLDAML-RQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAID 896
Cdd:cd14546   156 YILIDMVLnRMAKGAKEIDIAATLEHLRDQRPGMVKTKDQFEFVLTAVAEEVN 208

PTPc-N13

cd14597

catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein ...

656-892

5.87e-56

catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein phosphatase non-receptor type 13 (PTPN13, also known as PTPL1) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN13 is an important regulator of tumor aggressiveness. It regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. In hepatocellular carcinoma, PTPN13 is a tumor suppressor. PTPN13 contains a FERM domain, five PDZ domains, and a C-terminal catalytic PTP domain. With its PDZ domains, PTPN13 has numerous interacting partners that can actively participate in the regulation of its phosphatase activity or can permit direct or indirect recruitment of tyrosine phosphorylated substrates. Its FERM domain is necessary for localization to the membrane.

Pssm-ID: 350445 [Multi-domain] Cd Length: 234 Bit Score: 194.28 E-value: 5.87e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  656 ENKPKNRYINIVAYDHTRVILkpipGQKksSDYINANYIDGYHKSRAF--IGTQGPLPATFDDYWRMVWEQRVCIIIMIT 733
Cdd:cd14597     2 ENRKKNRYKNILPYDTTRVPL----GDE--GGYINASFIKMPVGDEEFvyIACQGPLPTTVADFWQMVWEQKSTVIAMMT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  734 NLVERGRRKCDMYWPKEGTETYGI---IQVKLVQeivmaTYTIRTFAIKNIKVKKKQASE-RTVYQYHYTNWPDHGVPDH 809
Cdd:cd14597    76 QEVEGGKIKCQRYWPEILGKTTMVdnrLQLTLVR-----MQQLKNFVIRVLELEDIQTREvRHITHLNFTAWPDHDTPSQ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  810 PLPVLSFVakSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14597   151 PEQLLTFI--SYMRHIHKSGPIITHCSAGIGRSGTLICIDVVLGLISKDLDFDISDIVRTMRLQRHGMVQTEDQYIFCYQ 228


                  ...
gi 998470296  890 ALL 892
Cdd:cd14597   229 VIL 231

PTPc-N3

cd14600

catalytic domain of tyrosine-protein phosphatase non-receptor type 3; Tyrosine-protein ...

645-892

6.12e-56

catalytic domain of tyrosine-protein phosphatase non-receptor type 3; Tyrosine-protein phosphatase non-receptor type 3 (PTPN3), also called protein-tyrosine phosphatase H1 (PTP-H1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN3 and p38gamma cooperate to promote Ras-induced oncogenesis. PTPN3 is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. Its PDZ domain binds with the PDZ-binding motif of p38gamma and enables efficient tyrosine dephosphorylation.

Pssm-ID: 350448 [Multi-domain] Cd Length: 274 Bit Score: 195.45 E-value: 6.12e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  645 PDLTSSYSQLNENKPKNRYINIVAYDHTRVILKpipgqkKSSDYINANYID----GYHKSRAFIGTQGPLPATFDDYWRM 720
Cdd:cd14600    28 PGLAITCAKLPQNMDKNRYKDVLPYDATRVVLQ------GNEDYINASYVNmeipSANIVNKYIATQGPLPHTCAQFWQV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  721 VWEQRVCIIIMITNLVERGRRKCDMYWPK-EGTETYGIIQVKLVQEIVMATYTIRTFAIKNIKVkkkqASERTVYQYHYT 799
Cdd:cd14600   102 VWEQKLSLIVMLTTLTERGRTKCHQYWPDpPDVMEYGGFRVQCHSEDCTIAYVFREMLLTNTQT----GEERTVTHLQYV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  800 NWPDHGVPDHPLPVLSFVaKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQ 879
Cdd:cd14600   178 AWPDHGVPDDSSDFLEFV-NYVRSKRVENEPVLVHCSAGIGRTGVLVTMETAMCLTERNQPVYPLDIVRKMRDQRAMMVQ 256

                         250
                  ....*....|...
gi 998470296  880 TEEQYVFIHDALL 892
Cdd:cd14600   257 TSSQYKFVCEAIL 269

R-PTP-Z-2

cd17669

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2; Receptor-type ...

989-1198

2.83e-55

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2; Receptor-type tyrosine-protein phosphatase Z (PTPRZ), also called receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Three isoforms are generated by alternative splicing from a single PTPRZ gene: two transmembrane isoforms, PTPRZ-A and PTPRZ-B, and one secretory isoform, PTPRZ-S (also known as phosphacan); all are preferentially expressed in the central nervous system (CNS) as chondroitin sulfate (CS) proteoglycans. PTPRZ isoforms play important roles in maintaining oligodendrocyte precursor cells in an undifferentiated state. PTPRZ is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the inactive PTP-like domain (repeat 2).

Pssm-ID: 350507 [Multi-domain] Cd Length: 204 Bit Score: 190.98 E-value: 2.83e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHPQF--WPDTDEEQDYGSFKVKPTGESV 1066
Cdd:cd17669     1 YINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLIVMLPDGQNMAEDEFvyWPNKDEPINCETFKVTLIAEEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1067 APPVAEEKgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKAFELVKEVgARQERDQNGPVVIVDRY 1146
Cdd:cd17669    81 KCLSNEEK----------LIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISII-KEEAANRDGPMIVHDEH 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 998470296 1147 GGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd17669   150 GGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFTDIEQYQFLYK 201

PTPc-N21_14

cd14540

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

688-893

3.83e-55

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and type 14 (PTPN14) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Both PTPN21 and PTPN14 contain an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350388 [Multi-domain] Cd Length: 219 Bit Score: 191.13 E-value: 3.83e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGY--HKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG----TETYGIIQVK 761
Cdd:cd14540     1 YINASHITATvgGKQRFYIAAQGPLQNTVGDFWQMVWEQGVYLVVMVTAEEEGGREKCFRYWPTLGgehdALTFGEYKVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  762 LVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFVAK-----------SSAANPPAagP 830
Cdd:cd14540    81 TKFSVSSGCYTTTGLRVKHTLSGQ----SRTVWHLQYTDWPDHGCPEDVSGFLDFLEEinsvrrhtnqdVAGHNRNP--P 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 998470296  831 MIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14540   155 TLVHCSAGVGRTGVVILADLMLYCLDHNEELDIPRVLALLRHQRMLLVQTLAQYKFVYNVLIQ 217

PTPc

Protein tyrosine phosphatase, catalytic domain;

933-1198

5.18e-55

Protein tyrosine phosphatase, catalytic domain;

Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 192.49 E-value: 5.18e-55

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    933 LLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGiDGSDYINATFLQGFNRLREFIVTQHPLM 1012
Cdd:smart00194    1 GLEEEFEKLDRLKPDDESCTVAAFPENRDKNRYKDVLPYDHTRVKLKPPPG-EGSDYINASYIDGPNGPKAYIATQGPLP 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1013 DTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPDT-DEEQDYGSFKVKPTGESVAPpvaeekgalmpgeggGLPSR 1088
Cdd:smart00194   80 STVEDFWRMVWEQKVTVIVMLTELVEKGRekcAQYWPDEeGEPLTYGDITVTLKSVEKVD---------------DYTIR 144

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1089 DFILQSTQDDYELACRLLLCPGWPQSCSPL-AKAF-ELVKEVGARQErDQNGPVVIVDRYGGTEAATFCCLSALYRQLER 1166
Cdd:smart00194  145 TLEVTNTGCSETRTVTHYHYTNWPDHGVPEsPESIlDLIRAVRKSQS-TSTGPIVVHCSAGVGRTGTFIAIDILLQQLEA 223

                           250       260       270
                    ....*....|....*....|....*....|..
gi 998470296   1167 EKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:smart00194  224 GKEVDIFEIVKELRSQRPGMVQTEEQYIFLYR 255

PTPc-N2

cd14607

catalytic domain of tyrosine-protein phosphatase non-receptor type 2; Tyrosine-protein ...

645-891

2.02e-54

catalytic domain of tyrosine-protein phosphatase non-receptor type 2; Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also called T-cell protein-tyrosine phosphatase (TCPTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN2, a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner. It is deleted in 6% of all T-cell acute lymphoblastic leukemias and is associated with constitutive JAK1/STAT5 signaling and tumorigenesis.

Pssm-ID: 350455 [Multi-domain] Cd Length: 257 Bit Score: 190.56 E-value: 2.02e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  645 PDLTSSYSQLNENKPKNRYINIVAYDHTRVILkpipgQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQ 724
Cdd:cd14607    12 HDYPHRVAKYPENRNRNRYRDVSPYDHSRVKL-----QNTENDYINASLVVIEEAQRSYILTQGPLPNTCCHFWLMVWQQ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  725 RVCIIIMITNLVERGRRKCDMYWPKEGTETYGI----IQVKLVQEIVMATYTIRTFAIKNIkvkkKQASERTVYQYHYTN 800
Cdd:cd14607    87 KTKAVVMLNRIVEKDSVKCAQYWPTDEEEVLSFketgFSVKLLSEDVKSYYTVHLLQLENI----NSGETRTISHFHYTT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  801 WPDHGVPDHPLPVLSFVAK--SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ--SVNVYGFLRHIRQQRNY 876
Cdd:cd14607   163 WPDFGVPESPASFLNFLFKvrESGSLSPEHGPAVVHCSAGIGRSGTFSLVDTCLVLMEKKDpdSVDIKQVLLDMRKYRMG 242

                         250
                  ....*....|....*
gi 998470296  877 LVQTEEQYVFIHDAL 891
Cdd:cd14607   243 LIQTPDQLRFSYMAV 257

PTPc-N14

cd14599

catalytic domain of tyrosine-protein phosphatase non-receptor type 14; Tyrosine-protein ...

635-893

2.87e-54

catalytic domain of tyrosine-protein phosphatase non-receptor type 14; Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), also called protein-tyrosine phosphatase pez, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN14 is a potential tumor suppressor and plays a regulatory role in the Hippo and Wnt/beta-catenin signaling pathways. It contains an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350447 [Multi-domain] Cd Length: 287 Bit Score: 191.36 E-value: 2.87e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  635 EYETFQHcTDPDLTSSYSQLNENKPKNRYINIVAYDHTRVILkpIPGQKKSSDYINANYI------DGYHksraFIGTQG 708
Cdd:cd14599    17 EYEQIPK-KKADGVFTTATLPENAERNRIREVVPYEENRVEL--VPTKENNTGYINASHIkvtvggEEWH----YIATQG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  709 PLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGT----ETYGIIQVklvqeivmaTYTIRT----FAIKN 780
Cdd:cd14599    90 PLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRSKSHRYWPKLGSkhssATYGKFKV---------TTKFRTdsgcYATTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  781 IKVKKK-QASERTVYQYHYTNWPDHGVPDHPLPVLSFVAK--------------SSAANPPaagpMIVHCSAGVGRTGTY 845
Cdd:cd14599   161 LKVKHLlSGQERTVWHLQYTDWPDHGCPEEVQGFLSYLEEiqsvrrhtnsmldsTKNCNPP----IVVHCSAGVGRTGVV 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14599   237 ILTELMIGCLEHNEKVEVPVMLRHLREQRMFMIQTIAQYKFVYQVLIQ 284

Y_phosphatase

Protein-tyrosine phosphatase;

959-1198

2.97e-54

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 189.38 E-value: 2.97e-54

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   959 NKAKNRSLNLIPIESHRVHITPKPGidGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:pfam00102    1 NLEKNRYKDVLPYDHTRVKLTGDPG--PSDYINASYIDGYKKPKKYIATQGPLPNTVEDFWRMVWEEKVTIIVMLTELEE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  1039 KEH---PQFWPDTDEE-QDYGSFKVKPTGEsvappVAEEKGALMpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQS 1114
Cdd:pfam00102   79 KGRekcAQYWPEEEGEsLEYGDFTVTLKKE-----KEDEKDYTV---------RTLEVSNGGSEETRTVKHFHYTGWPDH 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  1115 CSPLAKA--FELVKEVGARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDD 1192
Cdd:pfam00102  145 GVPESPNslLDLLRKVRKSSLDGRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAEGEVDIFQIVKELRSQRPGMVQTLEQ 224


                   ....*.
gi 998470296  1193 FLFLYR 1198
Cdd:pfam00102  225 YIFLYD 230

R-PTPc-E-2

cd14622

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 2; Receptor-type ...

687-888

6.99e-51

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 2; Receptor-type tyrosine-protein phosphatase E (PTPRE), also known as receptor-type tyrosine-protein phosphatase epsilon (R-PTP-epsilon), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. The PTPRE gene contains two distinct promoters that generate the two major isoforms: transmembrane (receptor type RPTPe or PTPeM) and cytoplasmic (cyt-PTPe or PTPeC). Receptor type RPTPe plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells, and may also play a role in osteoclast formation and function. It also negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis. cyt-PTPe acts as a negative regulator of insulin receptor signaling in skeletal muscle. It regulates insulin-induced phosphorylation of proteins downstream of the insulin receptor. Receptor type RPTPe contains a small extracellular region, a single transmembrane segment, and an intracellular region two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350470 [Multi-domain] Cd Length: 205 Bit Score: 178.66 E-value: 6.99e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  687 DYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEI 766
Cdd:cd14622     1 DYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMVWEWKCHTIVMLTELQEREQEKCVQYWPSEGSVTHGEITIEIKNDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  767 VMATYTIRTFAIKNIKVKKKqaseRTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAG-PMIVHCSAGVGRTGTY 845
Cdd:cd14622    81 LLETISIRDFLVTYNQEKQT----RLVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNhPIVVHCSAGAGRTGTF 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 998470296  846 IVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd14622   157 IALSNILERVKAEGLLDVFQTVKSLRLQRPHMVQTLEQYEFCY 199

PHA02738

hypothetical protein; Provisional

650-902

1.26e-50

hypothetical protein; Provisional

Pssm-ID: 222923 [Multi-domain] Cd Length: 320 Bit Score: 182.05 E-value: 1.26e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  650 SYSQLNENKPKNRYINIVAYDHTRVILkpiPGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCII 729
Cdd:PHA02738   42 TFNAEKKNRKLNRYLDAVCFDHSRVIL---PAERNRGDYINANYVDGFEYKKKFICGQAPTRQTCYDFYRMLWMEHVQII 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  730 IMITNLVERGRRKCDMYWP--KEGTETYGIIQVKLVQEIVMATYTIRTfaiknIKVKKKQASERTVYQYHYTNWPDHGVP 807
Cdd:PHA02738  119 VMLCKKKENGREKCFPYWSdvEQGSIRFGKFKITTTQVETHPHYVKST-----LLLTDGTSATQTVTHFNFTAWPDHDVP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  808 DHPLPVLSFV------AKSSAAN----------PPaagPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIR 871
Cdd:PHA02738  194 KNTSEFLNFVlevrqcQKELAQEslqighnrlqPP---PIVVHCNAGLGRTPCYCVVDISISRFDACATVSIPSIVSSIR 270

                         250       260       270
                  ....*....|....*....|....*....|.
gi 998470296  872 QQRNYLVQTEEQYVFIHDALLEAIDSGDTEV 902
Cdd:PHA02738  271 NQRYYSLFIPFQYFFCYRAVKRYVNLTVNKV 301

R-PTP-C-2

cd14558

PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2; Receptor-type ...

688-889

1.85e-50

PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2; Receptor-type tyrosine-protein phosphatase C (PTPRC), also known as CD45, leukocyte common antigen (LCA) or GP180, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRC/CD45 is found in all nucleated hematopoietic cells and is an essential regulator of T- and B-cell antigen receptor signaling. It controls immune response, both positively and negatively, by dephosphorylating a number of signaling molecules such as the Src family kinases, the CD3zeta chain of TCY, and ZAP-70 kinase. Mutations in the human PTPRC/CD45 gene are associated with severe combined immunodeficiency (SCID) and multiple sclerosis. PTPRC/CD45 contains an extracellular receptor-like region with fibronectin type III (FN3) repeats, a short transmembrane segment, and a cytoplasmic region comprising of a membrane proximal catalytically active PTP domain (repeat 1 or D1) and a membrane distal catalytically impaired PTP-like domain (repeat 2, or D2). This model represents repeat 2.

Pssm-ID: 350406 [Multi-domain] Cd Length: 203 Bit Score: 177.20 E-value: 1.85e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPkEGTETYGIIQVKLVQEIV 767
Cdd:cd14558     1 YINASFIDGYWGPKSLIATQGPLPDTIADFWQMIFQKKVKVIVMLTELKEGDQEQCAQYWG-DEKKTYGDIEVELKDTEK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFV------AKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14558    80 SPTYTVRVFEITHLKRKD----SRTVYQYQYHKWKGEELPEKPKDLVDMIksikqkLPYKNSKHGRSVPIVVHCSDGSSR 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14558   156 TGIFCALWNLLESAETEKVVDVFQVVKALRKQRPGMVSTLEQYQFLYD 203

PTPc-N4

cd14601

catalytic domain of tyrosine-protein phosphatase non-receptor type 4; Tyrosine-protein ...

687-896

3.14e-49

catalytic domain of tyrosine-protein phosphatase non-receptor type 4; Tyrosine-protein phosphatase non-receptor type 4 (PTPN4), also called protein-tyrosine phosphatase MEG1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN4 functions in TCR cell signaling, apoptosis, cerebellar synaptic plasticity, and innate immune responses. It specifically inhibits the TRIF-dependent TLR4 pathway by suppressing tyrosine phosphorylation of TRAM. It is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain; the PDZ domain regulates the catalytic activity of PTPN4.

Pssm-ID: 350449 [Multi-domain] Cd Length: 212 Bit Score: 173.98 E-value: 3.14e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  687 DYINANYIDGYHKS----RAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPK-EGTETYGIIQVK 761
Cdd:cd14601     1 DYINANYINMEIPSssiiNRYIACQGPLPNTCSDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEpSGSSSYGGFQVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  762 LVQEIVMATYTIRTFAIKNIKVKKkqasERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14601    81 CHSEEGNPAYVFREMTLTNLEKNE----SRPLTQIQYIAWPDHGVPDDSSDFLDFVCLVRNKRAGKDEPVVVHCSAGIGR 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAID 896
Cdd:cd14601   157 TGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE 211

PTPc-N20

cd14596

catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein ...

688-895

6.37e-49

catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization.

Pssm-ID: 350444 [Multi-domain] Cd Length: 207 Bit Score: 173.01 E-value: 6.37e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGY--HKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEGTETYGI--IQVKLV 763
Cdd:cd14596     1 YINASYITMPvgEEELFYIATQGPLPSTIDDFWQMVWENRSDVIAMMTREVERGKVKCHRYWPETLQEPMELenYQLRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  764 QEIVMATYTIRTFAIknikVKKKQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANppAAGPMIVHCSAGVGRTG 843
Cdd:cd14596    81 NYQALQYFIIRIIKL----VEKETGENRLIKHLQFTTWPDHGTPQSSDQLVKFICYMRKVH--NTGPIVVHCSAGIGRAG 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 998470296  844 TYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:cd14596   155 VLICVDVLLSLIEKDLSFNIKDIVREMRQQRYGMIQTKDQYLFCYKVVLEVL 206

R-PTP-G-2

cd17670

PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2; Receptor-type ...

989-1198

8.83e-49

PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2; Receptor-type tyrosine-protein phosphatase G (PTPRG), also called protein-tyrosine phosphatase gamma (R-PTP-gamma), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRG is an important tumor suppressor gene in multiple human cancers such as lung, ovarian, and breast cancers. It is widely expressed in many tissues, including the central nervous system, where it plays a role during neuroinflammation processes. It can dephosphorylate platelet-derived growth factor receptor beta (PDGFRB) and may play a role in PDGFRB-related infantile myofibromatosis. PTPRG is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the inactive PTP-like domain (repeat 2).

Pssm-ID: 350508 [Multi-domain] Cd Length: 205 Bit Score: 172.56 E-value: 8.83e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVL---SVVDEKEHpQFWPDTDEEQDYGSFKVKPTGES 1065
Cdd:cd17670     1 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLpdnQGLAEDEF-VYWPSREESMNCEAFTVTLISKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 VAPPVAEEKgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKAFELVKeVGARQERDQNGPVVIVDR 1145
Cdd:cd17670    80 RLCLSNEEQ----------IIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELIN-VIKEEALTRDGPTIVHDE 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 998470296 1146 YGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd17670   149 FGAVSAGTLCALTTLSQQLENENAVDVYQVAKMINLMRPGVFTDIEQYQFLYK 201

PHA02747

protein tyrosine phosphatase; Provisional

637-888

1.16e-46

protein tyrosine phosphatase; Provisional

Pssm-ID: 165114 [Multi-domain] Cd Length: 312 Bit Score: 170.18 E-value: 1.16e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  637 ETFQHCTDP-DLTSSYSQLNENKPKNRYINIVAYDHTRVILKPipGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFD 715
Cdd:PHA02747   30 EHHQIILKPfDGLIANFEKPENQPKNRYWDIPCWDHNRVILDS--GGGSTSDYIHANWIDGFEDDKKFIATQGPFAETCA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  716 DYWRMVWEQRVCIIIMIT-NLVERGRRKCDMYW-PKE-GTETYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQASERT 792
Cdd:PHA02747  108 DFWKAVWQEHCSIIVMLTpTKGTNGEEKCYQYWcLNEdGNIDMEDFRIETLKTSVRAKYILTLIEITD----KILKDSRK 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  793 VYQYHYTNWPDHGVP-DHP-----LPVLSFVAKSSAA--NPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVN 862
Cdd:PHA02747  184 ISHFQCSEWFEDETPsDHPdfikfIKIIDINRKKSGKlfNPKDAllCPIVVHCSDGVGKTGIFCAVDICLNQLVKRKAIC 263

                         250       260
                  ....*....|....*....|....*.
gi 998470296  863 VYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:PHA02747  264 LAKTAEKIREQRHAGIMNFDDYLFIQ 289

PTP-N23

cd14539

PTP-like domain of tyrosine-protein phosphatase non-receptor type 23; Tyrosine-protein ...

688-889

2.11e-46

PTP-like domain of tyrosine-protein phosphatase non-receptor type 23; Tyrosine-protein phosphatase non-receptor type 23 (PTPN23), also called His domain-containing protein tyrosine phosphatase (HD-PTP) or protein tyrosine phosphatase TD14 (PTP-TD14), is a catalytically inactive member of the tyrosine-specific protein tyrosine phosphatase (PTP) family. Human PTPN23 may be involved in the regulation of small nuclear ribonucleoprotein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. It plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. PTPN23 contains five domains: a BRO1-like domain that plays a role in endosomal sorting; a V-domain that interacts with Lys63-linked polyubiquitinated substrates; a central proline-rich region that might recruit SH3-containing proteins; a PTP-like domain; and a proteolytic degradation-targeting motif, also known as a PEST sequence.

Pssm-ID: 350387 [Multi-domain] Cd Length: 205 Bit Score: 165.63 E-value: 2.11e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRA-FIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKE--GTETYGIIQVKLVQ 764
Cdd:cd14539     1 YINASLIEDLTPYCPrFIATQAPLPGTAADFWLMVYEQQVSVIVMLVSEQENEKQKVHRYWPTErgQALVYGAITVSLQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  765 EIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDHGVPDHPLPVLSF---VAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14539    81 VRTTPTHVERIISIQH----KDTRLSRSVVHLQFTTWPELGLPDSPNPLLRFieeVHSHYLQQRSLQTPIVVHCSSGVGR 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 998470296  842 TGTYIVLDAMLRQMRQ-RQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14539   157 TGAFCLLYAAVQEIEAgNGIPDLPQLVRKMRQQRKYMLQEKEHLKFCYE 205

PHA02742

protein tyrosine phosphatase; Provisional

655-893

2.84e-46

protein tyrosine phosphatase; Provisional

Pssm-ID: 165109 [Multi-domain] Cd Length: 303 Bit Score: 168.64 E-value: 2.84e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  655 NENKPKNRYINIVAYDHTRVILkpiPGQKKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITN 734
Cdd:PHA02742   50 LKNMKKCRYPDAPCFDRNRVIL---KIEDGGDDFINASYVDGHNAKGRFICTQAPLEETALDFWQAIFQDQVRVIVMITK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  735 LVERGRRKCDMYW-PKE-GTETYGIIQVKlvqeiVMATYTIRTFAIKNIKVKKKQ-ASERTVYQYHYTNWPDHGVPDHPL 811
Cdd:PHA02742  127 IMEDGKEACYPYWmPHErGKATHGEFKIK-----TKKIKSFRNYAVTNLCLTDTNtGASLDIKHFAYEDWPHGGLPRDPN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  812 PVLSFV-----------AKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQT 880
Cdd:PHA02742  202 KFLDFVlavreadlkadVDIKGENIVKEPPILVHCSAGLDRAGAFCAIDICISKYNERAIIPLLSIVRDLRKQRHNCLSL 281

                         250
                  ....*....|...
gi 998470296  881 EEQYVFIHDALLE 893
Cdd:PHA02742  282 PQQYIFCYFIVLI 294

PHA02746

protein tyrosine phosphatase; Provisional

648-895

1.64e-45

protein tyrosine phosphatase; Provisional

Pssm-ID: 165113 [Multi-domain] Cd Length: 323 Bit Score: 167.13 E-value: 1.64e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  648 TSSYSQLNENKPKNRYINIVAYDHTRVILKP------------------IPGQKKSSDYINANYIDGYHKSRAFIGTQGP 709
Cdd:PHA02746   42 TTNHFLKKENLKKNRFHDIPCWDHSRVVINAheslkmfdvgdsdgkkieVTSEDNAENYIHANFVDGFKEANKFICAQGP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  710 LPATFDDYWRMVWEQRVCIIIMITNlVERGRRKCDMYWPK-EGTE-TYGIIQVKLVQEIVMATYTIRTFAIKNikvkKKQ 787
Cdd:PHA02746  122 KEDTSEDFFKLISEHESQVIVSLTD-IDDDDEKCFELWTKeEDSElAFGRFVAKILDIIEELSFTKTRLMITD----KIS 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  788 ASERTVYQYHYTNWPDHGVPDHPLPVLSFVAK----------SSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQ 857
Cdd:PHA02746  197 DTSREIHHFWFPDWPDNGIPTGMAEFLELINKvneeqaelikQADNDPQTLGPIVVHCSAGIGRAGTFCAIDNALEQLEK 276

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 998470296  858 RQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLEAI 895
Cdd:PHA02746  277 EKEVCLGEIVLKIRKQRHSSVFLPEQYAFCYKALKYAI 314

R-PTPc-typeIIb-2

cd14556

PTP domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat ...

688-889

5.45e-45

PTP domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The type IIb (or R2B) subfamily of receptor protein tyrosine phosphatases (RPTPs) include the prototypical member PTPmu (or PTPRM), PCP-2 (or PTPRU), PTPrho (or PTPRT), and PTPkappa (or PTPRK). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Type IIb RPTPs mediate cell-cell adhesion though homophilic interactions; their ligand is an identical molecule on an adjacent cell. No heterophilic interactions between the subfamily members have been observed. They also commonly function as tumor suppressors. They contain an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350404 [Multi-domain] Cd Length: 201 Bit Score: 161.42 E-value: 5.45e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMItNLVERGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14556     1 YINAALLDSYKQPAAFIVTQHPLPNTVTDFWRLVYDYGCTSIVML-NQLDPKDQSCPQYWPDEGSGTYGPIQVEFVSTTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIkvKKKQASERTVYQYHYTNWPDHG----VPDHPLPVLSFVAKSSAANppAAGPMIVHCSAGVGRTG 843
Cdd:cd14556    80 DEDVISRIFRLQNT--TRPQEGYRMVQQFQFLGWPRDRdtppSKRALLKLLSEVEKWQEQS--GEGPIVVHCLNGVGRSG 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 998470296  844 TYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHD 889
Cdd:cd14556   156 VFCAISSVCERIKVENVVDVFQAVKTLRNHRPNMVETEEQYKFCYD 201

PTPc_plant_PTP1

cd17658

protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs; Arabidopsis ...

688-888

7.33e-45

protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs; Arabidopsis thaliana protein tyrosine phosphatase 1 (AtPTP1) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. AtPTP1 dephosphorylates and inhibits MAP kinase 6 (MPK6) in non-oxidative stress conditions. Together with MAP kinase phosphatase 1 (MKP1) it expresses salicylic acid (SA) and camalexin biosynthesis, and therefore, modulating defense response.

Pssm-ID: 350496 [Multi-domain] Cd Length: 206 Bit Score: 161.09 E-value: 7.33e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYI--DGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRR-KCDMYWPKE--GTETYGIIQVKL 762
Cdd:cd17658     1 YINASLVetPASESLPKFIATQGPLPHTFEDFWEMVIQQRCPVIIMLTRLVDNYSTaKCADYFPAEenESREFGRISVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  763 VQE-IVMATYTIRTFAIKNIKVkkkQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAAnPPAAGPMIVHCSAGVGR 841
Cdd:cd17658    81 KKLkHSQHSITLRVLEVQYIES---EEPPLSVLHIQYPEWPDHGVPKDTRSVRELLKRLYGI-PPSAGPIVVHCSAGIGR 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 998470296  842 TGTYIVLDAMLRQMRQ--RQSVNVYGFLRHIRQQRNYLVQTEEQYVFIH 888
Cdd:cd17658   157 TGAYCTIHNTIRRILEgdMSAVDLSKTVRKFRSQRIGMVQTQDQYIFCY 205

COG5599

Protein tyrosine phosphatase [Signal transduction mechanisms];

651-887

4.23e-43

Protein tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 444335 [Multi-domain] Cd Length: 282 Bit Score: 158.72 E-value: 4.23e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  651 YSQLNENKPKNRYINIVAYDHTRVilkpipgqKKSSDYINANYIDGYHKSRAfIGTQGPLPATFDDYWRMVWEQRVCIII 730
Cdd:COG5599    36 YLQNINGSPLNRFRDIQPYKETAL--------RANLGYLNANYIQVIGNHRY-IATQYPLEEQLEDFFQMLFDNNTPVLV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  731 MITNLVERGRRKCDM--YWPKEGTETYGIIQVKLVQEIVMATytirTFAIKNIKVKKKQASE--RTVYQYHYTNWPDHGV 806
Cdd:COG5599   107 VLASDDEISKPKVKMpvYFRQDGEYGKYEVSSELTESIQLRD----GIEARTYVLTIKGTGQkkIEIPVLHVKNWPDHGA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  807 PD----HPLpvLSFVAKSSAANPPAAGPMIVHCSAGVGRTGTYIVLDAMlRQMRQRQ---SVNVYGFLRHIRQQRNY-LV 878
Cdd:COG5599   183 ISaealKNL--ADLIDKKEKIKDPDKLLPVVHCRAGVGRTGTLIACLAL-SKSINALvqiTLSVEEIVIDMRTSRNGgMV 259


                  ....*....
gi 998470296  879 QTEEQYVFI 887
Cdd:COG5599   260 QTSEQLDVL 268

R-PTP-LAR-2

cd14554

PTP-like domain of the LAR family receptor-type tyrosine-protein phosphatases, repeat 2; The ...

957-1198

2.59e-42

Pssm-ID: 350402 [Multi-domain] Cd Length: 238 Bit Score: 154.99 E-value: 2.59e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  957 PCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV 1036
Cdd:cd14554     4 PCNKFKNRLVNILPYESTRVCLQPIRGVEGSDYINASFIDGYRQRGAYIATQGPLAETTEDFWRMLWEHNSTIIVMLTKL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1037 DEKEHP---QFWPdTDEEQDYGSFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELACRLLLCPGWPQ 1113
Cdd:cd14554    84 REMGREkchQYWP-AERSARYQYFVVDPMAEYNMPQYI---------------LREFKVTDARDGQSRTVRQFQFTDWPE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1114 SCSP-LAKAF-ELVKEV-GARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQ 1190
Cdd:cd14554   148 QGVPkSGEGFiDFIGQVhKTKEQFGQEGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDVFQTVKLLRTQRPAMVQTE 227


                  ....*...
gi 998470296 1191 DDFLFLYR 1198
Cdd:cd14554   228 DQYQFCYR 235

PTPc-N21

cd14598

catalytic domain of tyrosine-protein phosphatase non-receptor type 21; Tyrosine-protein ...

688-893

1.60e-41

catalytic domain of tyrosine-protein phosphatase non-receptor type 21; Tyrosine-protein phosphatase non-receptor type 21 (PTPN21), also called protein-tyrosine phosphatase D1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN21 is a component of a multivalent scaffold complex nucleated by focal adhesion kinase (FAK) at specific intracellular sites. It promotes cytoskeleton events that induce cell adhesion and migration by modulating Src-FAK signaling. It can also selectively associate with and stimulate Tec family kinases and modulate Stat3 activation. Human PTPN21 may also play a pathologic role in gastrointestinal tract tumorigenesis. PTPN21 contains an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350446 [Multi-domain] Cd Length: 220 Bit Score: 152.05 E-value: 1.60e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGY--HKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWPKEG----TETYGIIQVk 761
Cdd:cd14598     1 YINASHIKVTvgGKEWDYIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGsrhnTVTYGRFKI- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  762 lvqeivmaTYTIRT----FAIKNIKVKK-KQASERTVYQYHYTNWPDHGVPDHPLPVLSFVAK--------SSAANPPAA 828
Cdd:cd14598    80 --------TTRFRTdsgcYATTGLKIKHlLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEiqsvrrhtNSTIDPKSP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296  829 G-PMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14598   152 NpPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDIPRVLDMLRQQRMMMVQTLSQYTFVYKVLIQ 217

R-PTP-D-2

cd14628

PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2; Receptor-type ...

900-1198

5.03e-41

Pssm-ID: 350476 [Multi-domain] Cd Length: 292 Bit Score: 153.35 E-value: 5.03e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  900 TEVGVSQLSRYVQSLQTAQVATTGAGdnekswslLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHIT 979
Cdd:cd14628     1 TEVPARNLYAYIQKLTQIETGENVTG--------MELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  980 PKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV----DEKEHpQFWPdTDEEQDYG 1055
Cdd:cd14628    73 PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLremgREKCH-QYWP-AERSARYQ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1056 SFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKA--FELVKEVGARQE 1133
Cdd:cd14628   151 YFVVDPMAEYNMPQYI---------------LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEgfIDFIGQVHKTKE 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296 1134 R-DQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14628   216 QfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYR 281

PTPc

cd00047

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1. ...

989-1198

1.17e-40

Pssm-ID: 350343 [Multi-domain] Cd Length: 200 Bit Score: 148.97 E-value: 1.17e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPD-TDEEQDYGSFKVKPTGE 1064
Cdd:cd00047     1 YINASYIDGYRGPKEYIATQGPLPNTVEDFWRMVWEQKVSVIVMLTNLVEKGRekcERYWPEeGGKPLEYGDITVTLVSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAPPVAEekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGW-----PQSCSPLAKAFELVKevgaRQERDQNGP 1139
Cdd:cd00047    81 EELSDYTI---------------RTLELSPKGCSESREVTHLHYTGWpdhgvPSSPEDLLALVRRVR----KEARKPNGP 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296 1140 VVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd00047   142 IVVHCSAGVGRTGTFIAIDILLERLEAEGEVDVFEIVKALRKQRPGMVQTLEQYEFIYE 200

PTPc_DSPc

smart00012

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ...

792-893

6.76e-40

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine phosphatases. Homologues detected by this profile and not by those of "PTPc" or "DSPc" are predicted to be protein phosphatases with a similar fold to DSPs and PTPs, yet with unpredicted specificities.

Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 142.88 E-value: 6.76e-40

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    792 TVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ-SVNVYGFLR 868
Cdd:smart00012    1 TVKHYHYTGWPDHGVPESPDSILELLRAVKKNLNQSEssGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAgEVDIFDTVK 80

                            90       100
                    ....*....|....*....|....*
gi 998470296    869 HIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:smart00012   81 ELRSQRPGMVQTEEQYLFLYRALLE 105

PTPc_motif

smart00404

Protein tyrosine phosphatase, catalytic domain motif;

792-893

6.76e-40

Protein tyrosine phosphatase, catalytic domain motif;

Pssm-ID: 214649 [Multi-domain] Cd Length: 105 Bit Score: 142.88 E-value: 6.76e-40

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    792 TVYQYHYTNWPDHGVPDHPLPVLSFVAKSSAANPPAA--GPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQ-SVNVYGFLR 868
Cdd:smart00404    1 TVKHYHYTGWPDHGVPESPDSILELLRAVKKNLNQSEssGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAgEVDIFDTVK 80

                            90       100
                    ....*....|....*....|....*
gi 998470296    869 HIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:smart00404   81 ELRSQRPGMVQTEEQYLFLYRALLE 105

R-PTP-S-2

cd14627

PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2; Receptor-type ...

899-1198

1.56e-39

Pssm-ID: 350475 [Multi-domain] Cd Length: 290 Bit Score: 148.73 E-value: 1.56e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  899 DTEVGVSQLSRYVQSLQTAQVATTGAGdnekswslLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHI 978
Cdd:cd14627     1 NTEVPARNLYSYIQKLAQVEVGEHVTG--------MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  979 TPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV----DEKEHpQFWPdTDEEQDY 1054
Cdd:cd14627    73 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLremgREKCH-QYWP-AERSARY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1055 GSFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKA--FELVKEVGARQ 1132
Cdd:cd14627   151 QYFVVDPMAEYNMPQYI---------------LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEgfIDFIGQVHKTK 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296 1133 ER-DQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14627   216 EQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 282

R-PTP-F-2

cd14629

PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2; Receptor-type ...

900-1198

1.63e-38

Pssm-ID: 350477 [Multi-domain] Cd Length: 291 Bit Score: 146.02 E-value: 1.63e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  900 TEVGVSQLSRYVQSLqtaqvattGAGDNEKSWSLLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHIT 979
Cdd:cd14629     2 TEVPARNLYAHIQKL--------TQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  980 PKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV----DEKEHpQFWPdTDEEQDYG 1055
Cdd:cd14629    74 PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLremgREKCH-QYWP-AERSARYQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1056 SFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELACRLLLCPGWPQSCSP-LAKAF-ELVKEVGARQE 1133
Cdd:cd14629   152 YFVVDPMAEYNMPQYI---------------LREFKVTDARDGQSRTIRQFQFTDWPEQGVPkTGEGFiDFIGQVHKTKE 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296 1134 R-DQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14629   217 QfGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYR 282

R-PTPc-typeIIb-2

cd14556

PTP domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat ...

989-1197

1.31e-36

Pssm-ID: 350404 [Multi-domain] Cd Length: 201 Bit Score: 137.15 E-value: 1.31e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH--PQFWPDtDEEQDYGSFKVKPTGESV 1066
Cdd:cd14556     1 YINAALLDSYKQPAAFIVTQHPLPNTVTDFWRLVYDYGCTSIVMLNQLDPKDQscPQYWPD-EGSGTYGPIQVEFVSTTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1067 APPVAeekgalmpgeggglpSRDFILQST---QDDYELAcRLLLCPGWP--QSCSPLAKAF-ELVKEVGARQERDQNGPV 1140
Cdd:cd14556    80 DEDVI---------------SRIFRLQNTtrpQEGYRMV-QQFQFLGWPrdRDTPPSKRALlKLLSEVEKWQEQSGEGPI 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296 1141 VIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14556   144 VVHCLNGVGRSGVFCAISSVCERIKVENVVDVFQAVKTLRNHRPNMVETEEQYKFCY 200

R-PTPc-A-2

cd14623

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2; Receptor-type ...

964-1198

5.65e-30

Pssm-ID: 350471 [Multi-domain] Cd Length: 228 Bit Score: 119.38 E-value: 5.65e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  964 RSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-- 1041
Cdd:cd14623     1 RVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLQHTIEDFWRMIWEWKSCSIVMLTELEERGQek 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1042 -PQFWPdTDEEQDYGSFKVKPTGESvappvaeekgalmpgEGGGLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPL-- 1118
Cdd:cd14623    81 cAQYWP-SDGSVSYGDITIELKKEE---------------ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSdg 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1119 AKAFELVKEVGARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14623   145 KGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYK 224

R3-PTPc

cd14548

catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar ...

964-1197

1.06e-29

Pssm-ID: 350396 [Multi-domain] Cd Length: 222 Bit Score: 118.23 E-value: 1.06e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  964 RSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK---- 1039
Cdd:cd14548     1 RYTNILPYDHSRVKLIPINEEEGSDYINANYIPGYNSPREFIATQGPLPGTKDDFWRMVWEQNSHTIVMLTQCMEKgrvk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 -EHpqFWPDTDEEQDYGSFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELA-CRLLLCP--GWPQSC 1115
Cdd:cd14548    81 cDH--YWPFDQDPVYYGDITVTMLSESVLPDWT---------------IREFKLERGDEVRSVRqFHFTAWPdhGVPEAP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1116 SPLAKAFELVkevgaRQERDQN-GPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVymYAKLYHMR--RPGIWKSQDD 1192
Cdd:cd14548   144 DSLLRFVRLV-----RDYIKQEkGPTIVHCSAGVGRTGTFIALDRLLQQIESEDYVDI--FGIVYDLRkhRPLMVQTEAQ 216


                  ....*
gi 998470296 1193 FLFLY 1197
Cdd:cd14548   217 YIFLH 221

R-PTPc-T-2

cd14634

PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2; Receptor-type ...

688-893

1.32e-29

PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2; Receptor-type tyrosine-protein phosphatase T (PTPRT), also known as receptor-type tyrosine-protein phosphatase rho (RPTP-rho or PTPrho), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRT is highly expressed in the nervous system and it plays a critical role in regulation of synaptic formation and neuronal development. It dephosphorylates a specific tyrosine residue in syntaxin-binding protein 1, a key component of synaptic vesicle fusion machinery, and regulates its binding to syntaxin 1. PTPRT has been identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350482 [Multi-domain] Cd Length: 206 Bit Score: 117.43 E-value: 1.32e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLveRGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14634     1 YINAALMDSHKQPAAFIVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DAAQLCMQYWPEKTSCCYGPIQVEFVSADI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNIKvkKKQASERTVYQYHYTNWPDHgvPDHP------LPVLSFVAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14634    79 DEDIISRIFRICNMA--RPQDGYRIVQHLQYIGWPAY--RDTPpskrsiLKVVRRLEKWQEQYDGREGRTVVHCLNGGGR 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14634   155 SGTFCAICSVCEMIQQQNIIDVFHTVKTLRNNKSNMVETLEQYKFVYEVALE 206

R-PTPc-LAR-1

cd14553

catalytic domain of LAR family receptor-type tyrosine-protein phosphatases, repeat 1; The LAR ...

957-1197

7.72e-29

Pssm-ID: 350401 [Multi-domain] Cd Length: 238 Bit Score: 116.34 E-value: 7.72e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  957 PCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV 1036
Cdd:cd14553     1 EVNKPKNRYANVIAYDHSRVILQPIEGVPGSDYINANYCDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1037 DEKEH---PQFWPDTDEEQdYGSFKVKPTgESVappvaeekgalmpgEGGGLPSRDFIL--QSTQDDYELacRLLLCPGW 1111
Cdd:cd14553    81 EERSRvkcDQYWPTRGTET-YGLIQVTLL-DTV--------------ELATYTVRTFALhkNGSSEKREV--RQFQFTAW 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1112 -----PQSCSPLakaFELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGI 1186
Cdd:cd14553   143 pdhgvPEHPTPF---LAFLRRVKACNPPDA-GPIVVHCSAGVGRTGCFIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYM 218

                         250
                  ....*....|.
gi 998470296 1187 WKSQDDFLFLY 1197
Cdd:cd14553   219 VQTEDQYIFIH 229

R-PTPc-K-2

cd14636

PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2; Receptor-type ...

688-893

2.15e-28

PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2; Receptor-type tyrosine-protein phosphatase K (PTPRK), also known as receptor-type tyrosine-protein phosphatase kappa (RPTP-kappa or PTPkappa), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRK is widely expressed and has been shown to stimulate cell motility and neurite outgrowth. It is required for anti-proliferative and pro-migratory effects of TGF-beta, suggesting a role in regulation, maintenance, and restoration of cell adhesion. It is a potential tumour suppressor in primary central nervous system lymphomas, colorectal cancer, and breast cancer. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350484 [Multi-domain] Cd Length: 206 Bit Score: 113.97 E-value: 2.15e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNL-VERGrrkCDMYWPKEGTETYGIIQVKLVQEI 766
Cdd:cd14636     1 YINAALMDSYRQPAAFIVTQHPLPNTVKDFWRLVYDYGCTSIVMLNEVdLAQG---CPQYWPEEGMLRYGPIQVECMSCS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  767 VMATYTIRTFAIKNIkvKKKQASERTVYQYHYTNWPDH-GVPDHPLPVLSF---VAKSSAANPPAAGPMIVHCSAGVGRT 842
Cdd:cd14636    78 MDCDVISRIFRICNL--TRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLilqVEKWQEECDEGEGRTIIHCLNGGGRS 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 998470296  843 GTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14636   156 GMFCAISIVCEMIKRQNVVDVFHAVKTLRNSKPNMVETPEQYRFCYDVALE 206

R-PTPc-U-2

cd14637

PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2; Receptor-type ...

688-893

5.22e-28

PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2; Receptor-type tyrosine-protein phosphatase U (PTPRU), also known as pancreatic carcinoma phosphatase 2 (PCP-2), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRU/PCP-2 is the most distant member of the type IIb subfamily and may have a distinct biological function other than cell-cell aggregation. It localizes to the adherens junctions and directly binds and dephosphorylates beta-catenin, and regulates the balance between signaling and adhesive beta-catenin. It plays an important role in the maintenance of epithelial integrity. PTPRU contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350485 [Multi-domain] Cd Length: 207 Bit Score: 112.69 E-value: 5.22e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRR-KCDMYWPKEGTETYGIIQVKLVQEI 766
Cdd:cd14637     1 YINAALTDSYTRSAAFIVTLHPLQNTTTDFWRLVYDYGCTSVVMLNQLNQSNSAwPCLQYWPEPGLQQYGPMEVEFVSGS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  767 VMATYTIRTFAIKNIkvKKKQASERTVYQYHYTNW-PDHGVPDHP---LPVLSFVAKSSAANppAAGPMIVHCSAGVGRT 842
Cdd:cd14637    81 ADEDIVTRLFRVQNI--TRLQEGHLMVRHFQFLRWsAYRDTPDSKkafLHLLASVEKWQRES--GEGRTVVHCLNGGGRS 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 998470296  843 GTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14637   157 GTYCASAMILEMIRCHNIVDVFYAVKTLRNYKPNMVETLEQYRFCYEIALE 207

R-PTPc-A-E-2

cd14552

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 2; ...

989-1198

2.24e-27

Pssm-ID: 350400 [Multi-domain] Cd Length: 202 Bit Score: 110.82 E-value: 2.24e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPdTDEEQDYGSFKVKPTGES 1065
Cdd:cd14552     1 YINASFIDGYRQKDAYIATQGPLDHTVEDFWRMIWEWKSCSIVMLTEIKERSQnkcAQYWP-EDGSVSSGDITVELKDQT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 vappvaeekgalmpgEGGGLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPL-AKAF-ELVKEVGARQERDQNGPVVIV 1143
Cdd:cd14552    80 ---------------DYEDYTLRDFLVTKGKGGSTRTVRQFHFHGWPEVGIPDnGKGMiDLIAAVQKQQQQSGNHPITVH 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 998470296 1144 DRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14552   145 CSAGAGRTGTFCALSTVLERVKAEGVLDVFQVVKSLRLQRPHMVQTLEQYEFCYK 199

R-PTPc-H

cd14619

catalytic domain of receptor-type tyrosine-protein phosphatase H; Receptor-type ...

963-1198

4.06e-27

Pssm-ID: 350467 [Multi-domain] Cd Length: 233 Bit Score: 111.13 E-value: 4.06e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK--- 1039
Cdd:cd14619     1 NRFRNVLPYDWSRVPLKPIHEEPGSDYINANYMPGYWSSQEFIATQGPLPQTVGDFWRMIWEQQSSTIVMLTNCMEAgrv 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 EHPQFWPDTDEEQDYGSFKVKPTGESVAPpvaeekgalmpgeggGLPSRDFILQSTQDDYELACRLLLCPGWPQSCSPLA 1119
Cdd:cd14619    81 KCEHYWPLDYTPCTYGHLRVTVVSEEVME---------------NWTVREFLLKQVEEQKTLSVRHFHFTAWPDHGVPSS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1120 KAFELVKEVGARQERDQN---GPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFL 1196
Cdd:cd14619   146 TDTLLAFRRLLRQWLDQTmsgGPTVVHCSAGVGRTGTLIALDVLLQQLQSEGLLGPFSFVQKMRENRPLMVQTESQYVFL 225


                  ..
gi 998470296 1197 YR 1198
Cdd:cd14619   226 HQ 227

R-PTPc-M-2

cd14635

PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2; Receptor-type ...

688-893

5.69e-27

PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2; Receptor-type tyrosine-protein phosphatase M (PTPRM), also known as protein-tyrosine phosphatase mu (R-PTP-mu or PTPmu), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRM/PTPmu is a homophilic cell adhesion molecule expressed in CNS neurons and glia. It is required for E-, N-, and R-cadherin-dependent neurite outgrowth. Loss of PTPmu contributes to tumor cell migration and dispersal of human glioblastomas. PTPRM contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350483 [Multi-domain] Cd Length: 206 Bit Score: 109.78 E-value: 5.69e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLveRGRRKCDMYWPKEGTETYGIIQVKLVQEIV 767
Cdd:cd14635     1 YINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSIVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  768 MATYTIRTFAIKNikVKKKQASERTVYQYHYTNWPDHgvPDHPLPVLSF------VAKSSAANPPAAGPMIVHCSAGVGR 841
Cdd:cd14635    79 EEDIISRIFRIYN--AARPQDGYRMVQQFQFLGWPMY--RDTPVSKRSFlklirqVDKWQEEYNGGEGRTVVHCLNGGGR 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALLE 893
Cdd:cd14635   155 SGTFCAISIVCEMLRHQRAVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 206

R5-PTP-2

cd14550

PTP-like domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The R5 ...

688-887

1.28e-26

Pssm-ID: 350398 [Multi-domain] Cd Length: 200 Bit Score: 108.56 E-value: 1.28e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGrrKCDMYWPKEGT----ETYGIIQV--K 761
Cdd:cd14550     1 YINASYLQGYRRSNEFIITQHPLEHTIKDFWQMIWDHNSQTIVMLTDNELNE--DEPIYWPTKEKplecETFKVTLSgeD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  762 LVQEIVMATYTIRTFAIKNikvkKKQASERTVYQYHYTNWPDhgvPDHPL-PVLSFVAKSSAANPPAAGPMIVHCSAGVG 840
Cdd:cd14550    79 HSCLSNEIRLIVRDFILES----TQDDYVLEVRQFQCPSWPN---PCSPIhTVFELINTVQEWAQQRDGPIVVHDRYGGV 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 998470296  841 RTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFI 887
Cdd:cd14550   152 QAATFCALTTLHQQLEHESSVDVYQVAKLYHLMRPGVFTSKEDYQFL 198

R-PTP-Z-2

cd17669

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2; Receptor-type ...

688-892

1.68e-26

Pssm-ID: 350507 [Multi-domain] Cd Length: 204 Bit Score: 108.54 E-value: 1.68e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCdMYWP-KEGTETYGIIQVKLVQEI 766
Cdd:cd17669     1 YINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLIVMLPDGQNMAEDEF-VYWPnKDEPINCETFKVTLIAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  767 VMATYTIRTFAIKNIKVKKKQASE-RTVYQYHYTNWPDhgvPDHPLPV---LSFVAKSSAANppAAGPMIVHCSAGVGRT 842
Cdd:cd17669    80 HKCLSNEEKLIIQDFILEATQDDYvLEVRHFQCPKWPN---PDSPISKtfeLISIIKEEAAN--RDGPMIVHDEHGGVTA 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 998470296  843 GTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:cd17669   155 GTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFTDIEQYQFLYKAIL 204

R-PTPc-E-2

cd14622

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 2; Receptor-type ...

988-1198

3.31e-26

Pssm-ID: 350470 [Multi-domain] Cd Length: 205 Bit Score: 107.40 E-value: 3.31e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  988 DYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHP---QFWPdTDEEQDYGSFKVKPTGE 1064
Cdd:cd14622     1 DYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMVWEWKCHTIVMLTELQEREQEkcvQYWP-SEGSVTHGEITIEIKND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAPPVAeekgalmpgeggglpSRDFILQSTQDDYELACRLLLCPGWPQSCSPL--AKAFELVKEVGARQERDQNGPVVI 1142
Cdd:cd14622    80 TLLETIS---------------IRDFLVTYNQEKQTRLVRQFHFHGWPEIGIPAegKGMIDLIAAVQKQQQQTGNHPIVV 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296 1143 VDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14622   145 HCSAGAGRTGTFIALSNILERVKAEGLLDVFQTVKSLRLQRPHMVQTLEQYEFCYR 200

R-PTPc-F-1

cd14626

catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1; Receptor-type ...

959-1197

4.53e-26

Pssm-ID: 350474 [Multi-domain] Cd Length: 276 Bit Score: 109.35 E-value: 4.53e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:cd14626    41 NKPKNRYANVIAYDHSRVILTSVDGVPGSDYINANYIDGYRKQNAYIATQGPLPETLSDFWRMVWEQRTATIVMMTRLEE 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1039 KEH---PQFWPDTDEEQdYGSFKVKptgesvappvaeekgALMPGEGGGLPSRDFILQSTQDDYELACRLLLCPGWPQSC 1115
Cdd:cd14626   121 KSRvkcDQYWPIRGTET-YGMIQVT---------------LLDTVELATYSVRTFALYKNGSSEKREVRQFQFMAWPDHG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1116 SP--LAKAFELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDF 1193
Cdd:cd14626   185 VPeyPTPILAFLRRVKACNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQY 263


                  ....
gi 998470296 1194 LFLY 1197
Cdd:cd14626   264 IFIH 267

R-PTPc-J

cd14615

catalytic domain of receptor-type tyrosine-protein phosphatase J; Receptor-type ...

963-1198

8.62e-26

Pssm-ID: 350463 [Multi-domain] Cd Length: 229 Bit Score: 107.21 E-value: 8.62e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITpKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK--- 1039
Cdd:cd14615     1 NRYNNVLPYDISRVKLS-VQSHSTDDYINANYMPGYNSKKEFIAAQGPLPNTVKDFWRMVWEKNVYAIVMLTKCVEQgrt 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 EHPQFWPdTDEEQDYGSFKVKPTGESVAPPvaeekgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSCSP-- 1117
Cdd:cd14615    80 KCEEYWP-SKQKKDYGDITVTMTSEIVLPE---------------WTIRDFTVKNAQTNESRTVRHFHFTSWPDHGVPet 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1118 ---LAKAFELVKEVgaRQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFL 1194
Cdd:cd14615   144 tdlLINFRHLVREY--MKQNPPNSPILVHCSAGVGRTGTFIAIDRLIYQIENENVVDVYGIVYDLRMHRPLMVQTEDQYV 221


                  ....
gi 998470296 1195 FLYR 1198
Cdd:cd14615   222 FLNQ 225

R-PTPc-V

cd14618

catalytic domain of receptor-type tyrosine-protein phosphatase V; Receptor-type ...

963-1197

1.81e-25

Pssm-ID: 350466 [Multi-domain] Cd Length: 230 Bit Score: 106.18 E-value: 1.81e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK--- 1039
Cdd:cd14618     1 NRYPHVLPYDHSRVRLSQLGGEPHSDYINANFIPGYTSPQEFIATQGPLKKTIEDFWRLVWEQQVCNIIMLTVGMENgrv 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 --EHpqFWPDTDEEQDYGSFKVKPTGESvappVAEEkgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGW-----P 1112
Cdd:cd14618    81 lcDH--YWPSESTPVSYGHITVHLLAQS----SEDE-----------WTRREFKLWHEDLRKERRVKHLHYTAWpdhgiP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1113 QSCSPLAKAFELVKEvgARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDD 1192
Cdd:cd14618   144 ESTSSLMAFRELVRE--HVQATKGKGPTLVHCSAGVGRSGTFIALDRLLRQLKEEKVVDVFNTVYILRMHRYLMIQTLSQ 221


                  ....*
gi 998470296 1193 FLFLY 1197
Cdd:cd14618   222 YIFLH 226

R-PTPc-S-1

cd14625

catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1; Receptor-type ...

959-1197

7.08e-25

Pssm-ID: 350473 [Multi-domain] Cd Length: 282 Bit Score: 105.95 E-value: 7.08e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:cd14625    47 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTKLEE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1039 KEH---PQFWPDTDEEQdYGSFKVKptgesvappvaeekgALMPGEGGGLPSRDFILQSTQDDYELACRLLLCPGWPQSC 1115
Cdd:cd14625   127 KSRikcDQYWPSRGTET-YGMIQVT---------------LLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1116 SPLAKA--FELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDF 1193
Cdd:cd14625   191 VPEYPTpfLAFLRRVKTCNPPDA-GPIVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQY 269


                  ....
gi 998470296 1194 LFLY 1197
Cdd:cd14625   270 SFIH 273

R-PTPc-O

cd14614

catalytic domain of receptor-type tyrosine-protein phosphatase O; Receptor-type ...

948-1198

5.01e-24

Pssm-ID: 350462 [Multi-domain] Cd Length: 245 Bit Score: 102.66 E-value: 5.01e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  948 DFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNS 1027
Cdd:cd14614     1 DIPHFAADLPVNRCKNRYTNILPYDFSRVKLVSMHEEEGSDYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1028 QTIVVLSVVDEKEH---PQFWPDTDEEQDYGSFKVKPTGESVAPpvaeekgalmpgeggglpsrDFILQSTQDDYELACR 1104
Cdd:cd14614    81 QIIVMLTQCNEKRRvkcDHYWPFTEEPVAYGDITVEMLSEEEQP--------------------DWAIREFRVSYADEVQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1105 LLL---CPGWPQSCSPLAKAFELVKEV--GARQERDQN-GPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKL 1178
Cdd:cd14614   141 DVMhfnYTAWPDHGVPTANAAESILQFvqMVRQQAVKSkGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSE 220

                         250       260
                  ....*....|....*....|
gi 998470296 1179 YHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14614   221 MRSYRMSMVQTEEQYIFIHQ 240

R-PTPc-G-1

cd17667

catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1; Receptor-type ...

957-1197

6.72e-24

Pssm-ID: 350505 [Multi-domain] Cd Length: 274 Bit Score: 102.81 E-value: 6.72e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  957 PCNKAKNRSLNLIPIESHRVHITPKPGIDG--SDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLS 1034
Cdd:cd17667    25 PDNKHKNRYINILAYDHSRVKLRPLPGKDSkhSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMIT 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1035 VVDEK---EHPQFWPdTDEEQDYGSFKVKPTGESVAP-----PVAEEKGALMPGEGGGLPSRDFILQSTQDDYElacrll 1106
Cdd:cd17667   105 NLVEKgrrKCDQYWP-TENSEEYGNIIVTLKSTKIHAcytvrRFSIRNTKVKKGQKGNPKGRQNERTVIQYHYT------ 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1107 lcpGWPQSCSP--LAKAFELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRP 1184
Cdd:cd17667   178 ---QWPDMGVPeyALPVLTFVRRSSAARTPEM-GPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRN 253

                         250
                  ....*....|...
gi 998470296 1185 GIWKSQDDFLFLY 1197
Cdd:cd17667   254 YLVQTEEQYIFIH 266

R-PTPc-A-1

cd14621

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1; Receptor-type ...

953-1198

1.96e-23

Pssm-ID: 350469 [Multi-domain] Cd Length: 296 Bit Score: 102.02 E-value: 1.96e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  953 SAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVV 1032
Cdd:cd14621    46 AASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1033 LSVVDEKEH---PQFWPDTDeEQDYGSFKVKptgesvappvAEEKGALMpgeggGLPSRDFILQSTQDDYELACRLLLC- 1108
Cdd:cd14621   126 VTNLKERKEckcAQYWPDQG-CWTYGNIRVS----------VEDVTVLV-----DYTVRKFCIQQVGDVTNKKPQRLITq 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1109 ---PGWPQSCSPLAK--AFELVKEVGARQERdQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRR 1183
Cdd:cd14621   190 fhfTSWPDFGVPFTPigMLKFLKKVKNCNPQ-YAGAIVVHCSAGVGRTGTFIVIDAMLDMMHAERKVDVYGFVSRIRAQR 268

                         250
                  ....*....|....*
gi 998470296 1184 PGIWKSQDDFLFLYR 1198
Cdd:cd14621   269 CQMVQTDMQYVFIYQ 283

R-PTP-C-2

cd14558

PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2; Receptor-type ...

989-1197

2.32e-23

Pssm-ID: 350406 [Multi-domain] Cd Length: 203 Bit Score: 99.39 E-value: 2.32e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVV---DEKEHPQFWPdtDEEQDYGSFKVKPTGES 1065
Cdd:cd14558     1 YINASFIDGYWGPKSLIATQGPLPDTIADFWQMIFQKKVKVIVMLTELkegDQEQCAQYWG--DEKKTYGDIEVELKDTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 VAPPVAEekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGW-----PQSCSPLAKAFELVKEVGA--RQERDQNG 1138
Cdd:cd14558    79 KSPTYTV---------------RVFEITHLKRKDSRTVYQYQYHKWkgeelPEKPKDLVDMIKSIKQKLPykNSKHGRSV 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296 1139 PVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14558   144 PIVVHCSDGSSRTGIFCALWNLLESAETEKVVDVFQVVKALRKQRPGMVSTLEQYQFLY 202

R-PTPc-E-1

cd14620

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1; Receptor-type ...

967-1198

5.25e-22

Pssm-ID: 350468 [Multi-domain] Cd Length: 229 Bit Score: 96.16 E-value: 5.25e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  967 NLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHP---Q 1043
Cdd:cd14620     3 NILPYDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEkcyQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1044 FWPDTDeEQDYGSFKVkptgesvappVAEEKGALMpgeggGLPSRDFILQSTQDDYELACRL---LLCPGWPQSCSPLA- 1119
Cdd:cd14620    83 YWPDQG-CWTYGNIRV----------AVEDCVVLV-----DYTIRKFCIQPQLPDGCKAPRLvtqLHFTSWPDFGVPFTp 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1120 ----KAFELVKEVGARQErdqnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLF 1195
Cdd:cd14620   147 igmlKFLKKVKSVNPVHA----GPIVVHCSAGVGRTGTFIVIDAMIDMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYSF 222


                  ...
gi 998470296 1196 LYR 1198
Cdd:cd14620   223 IYQ 225

PTPc-N9

cd14543

catalytic domain of tyrosine-protein phosphatase non-receptor type 9; Tyrosine-protein ...

950-1059

5.51e-22

Pssm-ID: 350391 [Multi-domain] Cd Length: 271 Bit Score: 97.05 E-value: 5.51e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  950 NVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQT 1029
Cdd:cd14543    20 TFLCSLAPANQEKNRYGDVLCLDQSRVKLPKRNGDERTDYINANFMDGYKQKNAYIATQGPLPKTYSDFWRMVWEQKVLV 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 998470296 1030 IVVLSVVDE---KEHPQFWP-DTDEEQDYGSFKV 1059
Cdd:cd14543   100 IVMTTRVVErgrVKCGQYWPlEEGSSLRYGDLTV 133

R-PTPc-B

cd14617

catalytic domain of receptor-type tyrosine-protein phosphatase B; Receptor-type ...

963-1173

7.01e-22

Pssm-ID: 350465 [Multi-domain] Cd Length: 228 Bit Score: 95.76 E-value: 7.01e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK--- 1039
Cdd:cd14617     1 NRYNNILPYDSTRVKLSNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKgrv 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 --EHpqFWPDTDEEQDYGSFKVKPTGESVAPPvaeekgalmpgegggLPSRDF-ILQSTQDDYELACRLLLCPGWPQSCS 1116
Cdd:cd14617    81 kcDH--YWPADQDSLYYGDLIVQMLSESVLPE---------------WTIREFkICSEEQLDAPRLVRHFHYTVWPDHGV 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1117 P--LAKAFELVKEVGARQERDQN-GPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVY 1173
Cdd:cd14617   144 PetTQSLIQFVRTVRDYINRTPGsGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIY 203

R-PTPc-D-1

cd14624

catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1; Receptor-type ...

959-1197

8.58e-22

Pssm-ID: 350472 [Multi-domain] Cd Length: 284 Bit Score: 97.11 E-value: 8.58e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:cd14624    47 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYINANYIDGYRKQNAYIATQGALPETFGDFWRMIWEQRSATVVMMTKLEE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1039 KEH---PQFWPDTDEEQdYGSFKVKptgesvappvaeekgALMPGEGGGLPSRDFILQSTQDDYELACRLLLCPGWPQSC 1115
Cdd:cd14624   127 RSRvkcDQYWPSRGTET-YGLIQVT---------------LLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1116 SPLAKA--FELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDF 1193
Cdd:cd14624   191 VPEHPTpfLAFLRRVKTCNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 269


                  ....
gi 998470296 1194 LFLY 1197
Cdd:cd14624   270 IFIH 273

R-PTPc-Q

cd14616

catalytic domain of receptor-type tyrosine-protein phosphatase Q; Receptor-type ...

963-1173

1.41e-21

Pssm-ID: 350464 [Multi-domain] Cd Length: 224 Bit Score: 94.59 E-value: 1.41e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH- 1041
Cdd:cd14616     1 NRFPNIKPYNNNRVKLIADAGVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTIVMLTQCFEKGRi 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1042 --PQFWPDTDEeqdygsfKVKPTGESVAPPVAEEKGAlmpgeggGLPSRDFILQStQDDYELA--CRLLLCP--GWPQSC 1115
Cdd:cd14616    81 rcHQYWPEDNK-------PVTVFGDIVITKLMEDVQI-------DWTIRDLKIER-HGDYMMVrqCNFTSWPehGVPESS 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296 1116 SPLAKafeLVKEVGARQERDqNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVY 1173
Cdd:cd14616   146 APLIH---FVKLVRASRAHD-NTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIY 199

R-PTP-G-2

cd17670

PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2; Receptor-type ...

688-892

2.15e-21

Pssm-ID: 350508 [Multi-domain] Cd Length: 205 Bit Score: 93.59 E-value: 2.15e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  688 YINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWEQRVCIIIMITNlvERGRRKCD-MYWP-KEGTETYGIIQVKLVQE 765
Cdd:cd17670     1 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPD--NQGLAEDEfVYWPsREESMNCEAFTVTLISK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  766 IVMATYTIRTFAIKNIKVKKKQASE-RTVYQYHYTNWPDhgvPDHPLPV---LSFVAKSSAANppAAGPMIVHCSAGVGR 841
Cdd:cd17670    79 DRLCLSNEEQIIIHDFILEATQDDYvLEVRHFQCPKWPN---PDAPISStfeLINVIKEEALT--RDGPTIVHDEFGAVS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 998470296  842 TGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQQRNYLVQTEEQYVFIHDALL 892
Cdd:cd17670   154 AGTLCALTTLSQQLENENAVDVYQVAKMINLMRPGVFTDIEQYQFLYKAML 204

PTPc-KIM

cd14547

catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; ...

963-1172

7.14e-21

Pssm-ID: 350395 [Multi-domain] Cd Length: 224 Bit Score: 92.84 E-value: 7.14e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  963 NRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLRE-FIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH 1041
Cdd:cd14547     1 NRYKTILPNEHSRVCLPSVDDDPLSSYINANYIRGYDGEEKaYIATQGPLPNTVADFWRMVWQEKTPIIVMITNLTEAKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1042 P--QFWPDTDEEQdYGSFKVkpTGESVAPPvaeekgalmpgEGGGLpsRDFILQSTQDDYElaCRLLLCPGWPQSCSP-L 1118
Cdd:cd14547    81 KcaQYWPEEENET-YGDFEV--TVQSVKET-----------DGYTV--RKLTLKYGGEKRY--LKHYWYTSWPDHKTPeA 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296 1119 AKAF-ELVKEV-GARQERDQNGPVVI-----VDRYGGTEAATFCClsalyRQLEREKCVDV 1172
Cdd:cd14547   143 AQPLlSLVQEVeEARQTEPHRGPIVVhcsagIGRTGCFIATSIGC-----QQLREEGVVDV 198

FN3

Fibronectin type 3 domain [General function prediction only];

196-438

1.62e-20

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 97.38 E-value: 1.62e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  196 VIGLKPFTVYSFRVLAVNAIGASKPSKEsFYMVTLREVPEgKPTIVHAQNTSSSSVRIQWTAPARHTIhgefEGYRItYR 275
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNE-VSVTTPTTPPS-APTGLTATADTPGSVTLSWDPVTESDA----TGYRV-YR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  276 prdRTQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVFNPAGR--GPAVVVPVMTDEGVPSSPVNLTAVRVTDTTVRL 353
Cdd:COG3401   269 ---SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  354 KWREPvrPNGVLQGYHVYfqpsRNGSSQQQRKTVSHPQPVEEYMLSGLKPFSFYDIWVKAFTQQHL-GESSNLLKVQTDV 432
Cdd:COG3401   346 SWTAS--SDADVTGYNVY----RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTAS 419


                  ....*.
gi 998470296  433 QGPSAP 438
Cdd:COG3401   420 AASGES 425

R-PTPc-M-1

cd14633

catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1; Receptor-type ...

953-1197

2.82e-20

Pssm-ID: 350481 [Multi-domain] Cd Length: 273 Bit Score: 92.41 E-value: 2.82e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  953 SAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVV 1032
Cdd:cd14633    34 SAKKDENRMKNRYGNIIAYDHSRVRLQPIEGETSSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1033 ---LSVVDEKEHPQFWPDTDEeqDYGSFKV-----KPTGESVAPPVAEEKgalmpgeggglpsrdfilQSTQDDYELacR 1104
Cdd:cd14633   114 vtnLVEVGRVKCCKYWPDDTE--IYKDIKVtlietELLAEYVIRTFAVEK------------------RGVHEIREI--R 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1105 LLLCPGWPQSCSPLAKA--FELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMR 1182
Cdd:cd14633   172 QFHFTGWPDHGVPYHATglLGFVRQVKSKSPPNA-GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSR 250

                         250
                  ....*....|....*
gi 998470296 1183 RPGIWKSQDDFLFLY 1197
Cdd:cd14633   251 RVNMVQTEEQYVFIH 265

PTPc-N11_6

cd14544

catalytic domain of tyrosine-protein phosphatase non-receptor type 11 and type 6; ...

959-1197

4.80e-20

Pssm-ID: 350392 [Multi-domain] Cd Length: 251 Bit Score: 90.98 E-value: 4.80e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPK-PGIDGSDYINATFL-----QGFNRLRE--FIVTQHPLMDTMADFWQMVWDHNSQTI 1030
Cdd:cd14544     1 NKGKNRYKNILPFDHTRVILKDRdPNVPGSDYINANYIrneneGPTTDENAktYIATQGCLENTVSDFWSMVWQENSRVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1031 VVLSVVDEKEHPQ---FWPDTDEEQDYGSFKVKPTGESVAPPVAEEKGALMPGEGGGLPSRDFILQSTQddyelacrlll 1107
Cdd:cd14544    81 VMTTKEVERGKNKcvrYWPDEGMQKQYGPYRVQNVSEHDTTDYTLRELQVSKLDQGDPIREIWHYQYLS----------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1108 cpgWPQSCSPL--AKAFELVKEVGARQE-RDQNGPVVIVDRYGGTEAATFCCLSALYRQLERE--KC-VDVYMYAKLYHM 1181
Cdd:cd14544   150 ---WPDHGVPSdpGGVLNFLEDVNQRQEsLPHAGPIVVHCSAGIGRTGTFIVIDMLLDQIKRKglDCdIDIQKTIQMVRS 226

                         250
                  ....*....|....*.
gi 998470296 1182 RRPGIWKSQDDFLFLY 1197
Cdd:cd14544   227 QRSGMVQTEAQYKFIY 242

PTPc-N7

cd14612

catalytic domain of tyrosine-protein phosphatase non-receptor type 7; Tyrosine-protein ...

957-1198

7.97e-20

Pssm-ID: 350460 [Multi-domain] Cd Length: 247 Bit Score: 90.28 E-value: 7.97e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  957 PCNKAKNRSLNLIPIESHRVHI-TPKPGIDGSDYINATFLQGFN-RLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLS 1034
Cdd:cd14612    13 PGHASKDRYKTILPNPQSRVCLrRAGSQEEEGSYINANYIRGYDgKEKAYIATQGPMLNTVSDFWEMVWQEECPIIVMIT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1035 VVDEKEHP--QFWPdtDEEQDYGSFKVKptgesvappVAEEKgalmpgEGGGLPSRDFILQstqddYELACRLL---LCP 1109
Cdd:cd14612    93 KLKEKKEKcvHYWP--EKEGTYGRFEIR---------VQDMK------ECDGYTIRDLTIQ-----LEEESRSVkhyWFS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1110 GW-----PQSCSPLakaFELVKEV-GARQERDQNGPVVI-----VDRYGGTEAATFCCLsalyrQLEREKCVDVYMYAKL 1178
Cdd:cd14612   151 SWpdhqtPESAGPL---LRLVAEVeESRQTAASPGPIVVhcsagIGRTGCFIATSIGCQ-----QLKDTGKVDILGIVCQ 222

                         250       260
                  ....*....|....*....|
gi 998470296 1179 YHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14612   223 LRLDRGGMIQTSEQYQFLHH 242

FN3

Fibronectin type 3 domain [General function prediction only];

132-352

8.79e-20

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 95.07 E-value: 8.79e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  132 VPDPPGIPIVVGFTSRSVDLSWTSSPNSHhsvILHYIIHIRIGEKGDWDTMNKVmtsdNSTNFQVIGLKPFTVYSFRVLA 211
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDPVTESD---ATGYRVYRSNSGDGPFTKVATV----TTTSYTDTGLTNGTTYYYRVTA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  212 VNAIG-ASKPSKESFymVTLREVPEGKPTIVHAQNTSSSSVRIQWTAPArhtiHGEFEGYRItYRprDRTQEESREIILR 290
Cdd:COG3401   305 VDAAGnESAPSNVVS--VTTDLTPPAAPSGLTATAVGSSSITLSWTASS----DADVTGYNV-YR--STSGGGTYTKIAE 375

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  291 DSKQTQYTIRNLETFTQYLVSLQVFNPAGRGPAVVVPVMTDEGVPSSPVNLTAVRVTDTTVR 352
Cdd:COG3401   376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTD 437

R-PTPc-T-2

cd14634

PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2; Receptor-type ...

989-1197

6.11e-19

Pssm-ID: 350482 [Multi-domain] Cd Length: 206 Bit Score: 86.61 E-value: 6.11e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTdEEQDYGSFKVkptgESVA 1067
Cdd:cd14634     1 YINAALMDSHKQPAAFIVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDAAQLcMQYWPEK-TSCCYGPIQV----EFVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAEEkgalmpgegggLPSRDFI---LQSTQDDYELACRLLLCpGWPQ-SCSPLAK--AFELVKEVGARQER--DQNGP 1139
Cdd:cd14634    76 ADIDED-----------IISRIFRicnMARPQDGYRIVQHLQYI-GWPAyRDTPPSKrsILKVVRRLEKWQEQydGREGR 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296 1140 VVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14634   144 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHTVKTLRNNKSNMVETLEQYKFVY 201

R-PTPc-T-1

cd14630

catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1; Receptor-type ...

959-1197

7.88e-19

Pssm-ID: 350478 [Multi-domain] Cd Length: 237 Bit Score: 87.00 E-value: 7.88e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVV---LSV 1035
Cdd:cd14630     3 NRNKNRYGNIISYDHSRVRLQLLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASVVMvtnLVE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1036 VDEKEHPQFWPdtDEEQDYGSFKVKPTGESvapPVAEekgalmpgegggLPSRDFILQSTQDDYELACRLLLCPGWPQSC 1115
Cdd:cd14630    83 VGRVKCVRYWP--DDTEVYGDIKVTLIETE---PLAE------------YVIRTFTVQKKGYHEIREIRQFHFTSWPDHG 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1116 SPLAKA--FELVKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDF 1193
Cdd:cd14630   146 VPCYATglLGFVRQVKFLNPPDA-GPIVVHCSAGAGRTGCFIAIDIMLDMAENEGVVDIFNCVRELRAQRVNMVQTEEQY 224


                  ....
gi 998470296 1194 LFLY 1197
Cdd:cd14630   225 VFVH 228

PHA02740

protein tyrosine phosphatase; Provisional

646-891

1.17e-18

protein tyrosine phosphatase; Provisional

Pssm-ID: 165107 [Multi-domain] Cd Length: 298 Bit Score: 88.10 E-value: 1.17e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  646 DLTSSYSQLNENKPK--NRYINIVAYDHTRVILKpipgqkKSSDYINANYIDGYHKSRAFIGTQGPLPATFDDYWRMVWE 723
Cdd:PHA02740   40 DEANKACAQAENKAKdeNLALHITRLLHRRIKLF------NDEKVLDARFVDGYDFEQKFICIINLCEDACDKFLQALSD 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  724 QRVCIIIMITNLVErgrRKC-DMYWP-KEGT-ETYGIIQVKLVQEIVMATYTIRTFAIKNikvkkKQASERTVYQYHYTN 800
Cdd:PHA02740  114 NKVQIIVLISRHAD---KKCfNQFWSlKEGCvITSDKFQIETLEIIIKPHFNLTLLSLTD-----KFGQAQKISHFQYTA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  801 WPDHGVPDHPLPVLSFV--AKSSAAN------PPAAGPMIVHCSAGVGRTGTYIVLDAMLRQMRQRQSVNVYGFLRHIRQ 872
Cdd:PHA02740  186 WPADGFSHDPDAFIDFFcnIDDLCADlekhkaDGKIAPIIIDCIDGISSSAVFCVFDICATEFDKTGMLSIANALKKVRQ 265

                         250
                  ....*....|....*....
gi 998470296  873 QRNYLVQTEEQYVFIHDAL 891
Cdd:PHA02740  266 KKYGCMNCLDDYVFCYHLI 284

R-PTPc-M-2

cd14635

PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2; Receptor-type ...

989-1197

1.44e-18

Pssm-ID: 350483 [Multi-domain] Cd Length: 206 Bit Score: 85.51 E-value: 1.44e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTDEEQdYGSFKVkptgESVA 1067
Cdd:cd14635     1 YINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSIVMLNDVDPAQLcPQYWPENGVHR-HGPIQV----EFVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAEEkgalmpgegggLPSRDFILQST---QDDYELACRLLLCpGWPQ-SCSPLAKA--FELVKEVGARQERDQNGP-- 1139
Cdd:cd14635    76 ADLEED-----------IISRIFRIYNAarpQDGYRMVQQFQFL-GWPMyRDTPVSKRsfLKLIRQVDKWQEEYNGGEgr 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296 1140 VVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14635   144 TVVHCLNGGGRSGTFCAISIVCEMLRHQRAVDVFHAVKTLRNNKPNMVDLLDQYKFCY 201

R5-PTPc-1

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 ...

989-1183

1.54e-18

Pssm-ID: 350397 [Multi-domain] Cd Length: 204 Bit Score: 85.48 E-value: 1.54e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK---EHPQFWPdTDEEQDYGSFKVKPTGES 1065
Cdd:cd14549     1 YINANYVDGYNKARAYIATQGPLPSTFDDFWRMVWEQNSAIIVMITNLVERgrrKCDQYWP-KEGTETYGNIQVTLLSTE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 VAPPVAEEKGALMPGEGGGLPSRDFILQSTQDDYElacrlllcpGWPQSCSP--LAKAFELVKEVgARQERDQNGPVVI- 1142
Cdd:cd14549    80 VLATYTVRTFSLKNLKLKKVKGRSSERVVYQYHYT---------QWPDHGVPdyTLPVLSFVRKS-SAANPPGAGPIVVh 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 998470296 1143 ----VDRYGgteaaTFCCLSALYRQLEREKCVDVYMYakLYHMRR 1183
Cdd:cd14549   150 csagVGRTG-----TYIVIDSMLQQIQDKGTVNVFGF--LKHIRT 187

PTPc-N11

cd14605

catalytic domain of tyrosine-protein phosphatase non-receptor type 11; Tyrosine-protein ...

959-1197

2.99e-18

Pssm-ID: 350453 [Multi-domain] Cd Length: 253 Bit Score: 85.84 E-value: 2.99e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITP-KPGIDGSDYINATFLQGFNRL--------REFIVTQHPLMDTMADFWQMVWDHNSQT 1029
Cdd:cd14605     2 NKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMPEFETkcnnskpkKSYIATQGCLQNTVNDFWRMVFQENSRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1030 IVVLSVVDEKEHPQ---FWPDTDEEQDYGSFKVKPTGESvappvaeekgalmpgeggglPSRDFIL------QSTQDDYE 1100
Cdd:cd14605    82 IVMTTKEVERGKSKcvkYWPDEYALKEYGVMRVRNVKES--------------------AAHDYILrelklsKVGQGNTE 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1101 LACRLLLCPGWPQSCSPL--AKAFELVKEVGARQER-DQNGPVVIVDRYGGTEAATFCCLSALYrQLEREK---C-VDVY 1173
Cdd:cd14605   142 RTVWQYHFRTWPDHGVPSdpGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILI-DIIREKgvdCdIDVP 220

                         250       260
                  ....*....|....*....|....
gi 998470296 1174 MYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14605   221 KTIQMVRSQRSGMVQTEAQYRFIY 244

PTPc-N18

cd14603

catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein ...

944-1065

6.19e-18

Pssm-ID: 350451 [Multi-domain] Cd Length: 266 Bit Score: 85.26 E-value: 6.19e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  944 FKAKD-FNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMV 1022
Cdd:cd14603    14 FKADYvCSTVAGGRKENVKKNRYKDILPYDQTRVILSLLQEEGHSDYINANFIKGVDGSRAYIATQGPLSHTVLDFWRMI 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 998470296 1023 WDHNSQTIVVlsVVDEKEHPQ-----FWPDTDEEQDYGSFKVKPTGES 1065
Cdd:cd14603    94 WQYGVKVILM--ACREIEMGKkkcerYWAQEQEPLQTGPFTITLVKEK 139

R-PTP-N

cd14609

PTP-like domain of receptor-type tyrosine-protein phosphatase N; Receptor-type ...

926-1195

6.24e-18

Pssm-ID: 350457 [Multi-domain] Cd Length: 281 Bit Score: 85.47 E-value: 6.24e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  926 DNEKSWSLLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINA-TFLQGFNRLREF 1004
Cdd:cd14609     9 DHLRNRDRLAKEWQALCAYQAEPNTCSTAQGEANVKKNRNPDFVPYDHARIKLKAESNPSRSDYINAsPIIEHDPRMPAY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1005 IVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDtDEEQDYGSFKVKPTGESVAppvaeekgalmpge 1081
Cdd:cd14609    89 IATQGPLSHTIADFWQMVWENGCTVIVMLTPLVEdgvKQCDRYWPD-EGSSLYHIYEVNLVSEHIW-------------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1082 ggglpSRDFILQS-------TQDDYELA-CRLLLCP--GWPQSCSPLakaFELVKEVGaRQERDQNGPVVIVDRYGGTEA 1151
Cdd:cd14609   154 -----CEDFLVRSfylknvqTQETRTLTqFHFLSWPaeGIPSSTRPL---LDFRRKVN-KCYRGRSCPIIVHCSDGAGRT 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 998470296 1152 ATFCCLS-ALYRQLEREKCVDVymYAKLYHMR--RPGIWKSQDDFLF 1195
Cdd:cd14609   225 GTYILIDmVLNRMAKGVKEIDI--AATLEHVRdqRPGMVRTKDQFEF 269

PTPc-N3_4

cd14541

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

988-1143

8.57e-18

Pssm-ID: 350389 [Multi-domain] Cd Length: 212 Bit Score: 83.53 E-value: 8.57e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  988 DYINATF----LQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE----KEHpQFWPDTDEEQDYGSFKV 1059
Cdd:cd14541     1 DYINANYvnmeIPGSGIVNRYIAAQGPLPNTCADFWQMVWEQKSTLIVMLTTLVErgrvKCH-QYWPDLGETMQFGNLQI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1060 KPTGESVAPPVAEekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQSCSPL-AKAF-ELVKEVgaRQERDQN 1137
Cdd:cd14541    80 TCVSEEVTPSFAF---------------REFILTNTNTGEERHITQMQYLAWPDHGVPDdSSDFlDFVKRV--RQNRVGM 142


                  ....*.
gi 998470296 1138 GPVVIV 1143
Cdd:cd14541   143 VEPTVV 148

R-PTPc-Z-1

cd17668

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 1; Receptor-type ...

989-1197

1.07e-17

Pssm-ID: 350506 [Multi-domain] Cd Length: 209 Bit Score: 83.10 E-value: 1.07e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK---EHPQFWPdTDEEQDYGSFKVKPTGES 1065
Cdd:cd17668     1 YINANYVDGYNKPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrKCDQYWP-ADGSEEYGNFLVTQKSVQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 VAP-----PVAEEKGALMPGEGGGLPSRDFILQ--STQddyelacrlllcpgWPQSCSP--LAKAFELVKEVGARQeRDQ 1136
Cdd:cd17668    80 VLAyytvrNFTLRNTKIKKGSQKGRPSGRVVTQyhYTQ--------------WPDMGVPeyTLPVLTFVRKASYAK-RHA 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296 1137 NGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd17668   145 VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH 205

PTPc-N3

cd14600

catalytic domain of tyrosine-protein phosphatase non-receptor type 3; Tyrosine-protein ...

951-1142

1.85e-17

Pssm-ID: 350448 [Multi-domain] Cd Length: 274 Bit Score: 84.13 E-value: 1.85e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  951 VVSAVKPCNKAKNRSLNLIPIESHRVHITpkpgiDGSDYINATFLQ----GFNRLREFIVTQHPLMDTMADFWQMVWDHN 1026
Cdd:cd14600    32 ITCAKLPQNMDKNRYKDVLPYDATRVVLQ-----GNEDYINASYVNmeipSANIVNKYIATQGPLPHTCAQFWQVVWEQK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1027 SQTIVVLSVVDE----KEHpQFWPDTDEEQDYGSFKVKPTGESVappvaeekgalmpgeGGGLPSRDFILQSTQDDYELA 1102
Cdd:cd14600   107 LSLIVMLTTLTErgrtKCH-QYWPDPPDVMEYGGFRVQCHSEDC---------------TIAYVFREMLLTNTQTGEERT 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 998470296 1103 CRLLLCPGWPQSCSP--LAKAFELVKEVgaRQERDQNGPVVI 1142
Cdd:cd14600   171 VTHLQYVAWPDHGVPddSSDFLEFVNYV--RSKRVENEPVLV 210

PTPc-N6

cd14606

catalytic domain of tyrosine-protein phosphatase non-receptor type 6; Tyrosine-protein ...

956-1064

3.77e-17

Pssm-ID: 350454 [Multi-domain] Cd Length: 266 Bit Score: 83.01 E-value: 3.77e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  956 KPCNKAKNRSLNLIPIESHRVHITPK-PGIDGSDYINATFLQgfNRL-------REFIVTQHPLMDTMADFWQMVWDHNS 1027
Cdd:cd14606    15 RPENKSKNRYKNILPFDHSRVILQGRdSNIPGSDYINANYVK--NQLlgpdenaKTYIASQGCLEATVNDFWQMAWQENS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 998470296 1028 QTIVVLSVVDEKEHPQ---FWPDTDEEQDYGSFKVKPTGE 1064
Cdd:cd14606    93 RVIVMTTREVEKGRNKcvpYWPEVGMQRAYGPYSVTNCGE 132

PTPc-N12

cd14604

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein ...

907-1064

7.54e-17

Pssm-ID: 350452 [Multi-domain] Cd Length: 297 Bit Score: 82.67 E-value: 7.54e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  907 LSRYVQSLQTAQVATTGAGDNEKSWSLLERqfKLVTMFKA-KDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGID 985
Cdd:cd14604     6 LKKFIERVQAMKSTDHNGEDNFASDFMRLR--RLSTKYRTeKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTSSQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  986 GSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDTDEEQ-DYGSFKVKP 1061
Cdd:cd14604    84 DSDYINANFIKGVYGPKAYIATQGPLANTVIDFWRMIWEYNVAIIVMACREFEmgrKKCERYWPLYGEEPmTFGPFRISC 163


                  ...
gi 998470296 1062 TGE 1064
Cdd:cd14604   164 EAE 166

PHA02746

protein tyrosine phosphatase; Provisional

955-1172

7.92e-17

protein tyrosine phosphatase; Provisional

Pssm-ID: 165113 [Multi-domain] Cd Length: 323 Bit Score: 83.15 E-value: 7.92e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  955 VKPCNKAKNRSLNLIPIESHRVHITPKPGI--------DG-----------SDYINATFLQGFNRLREFIVTQHPLMDTM 1015
Cdd:PHA02746   47 LKKENLKKNRFHDIPCWDHSRVVINAHESLkmfdvgdsDGkkievtsednaENYIHANFVDGFKEANKFICAQGPKEDTS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1016 ADFWQMVWDHNSQTIVVLSVVDEKEHPQF--W-PDTDEEQDYGSFKVKPTgesvapPVAEEKgalmpgeggGLPSRDFIL 1092
Cdd:PHA02746  127 EDFFKLISEHESQVIVSLTDIDDDDEKCFelWtKEEDSELAFGRFVAKIL------DIIEEL---------SFTKTRLMI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1093 QSTQDDYELACRLLLCPGWPQSCSP--LAKAFELVKEVGARQER---------DQNGPVVIVDRYGGTEAATFCCLSALY 1161
Cdd:PHA02746  192 TDKISDTSREIHHFWFPDWPDNGIPtgMAEFLELINKVNEEQAElikqadndpQTLGPIVVHCSAGIGRAGTFCAIDNAL 271

                         250
                  ....*....|.
gi 998470296 1162 RQLEREKCVDV 1172
Cdd:PHA02746  272 EQLEKEKEVCL 282

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

133-224

8.15e-17

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 76.77 E-value: 8.15e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  133 PDPPGIPIVVGFTSRSVDLSWTSsPNSHHSVILHYIIHIRIGEKGDWDTMNKVMTsdNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTP-PEDDGGPITGYVVEYREKGSGDWKEVEVTPG--SETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|..
gi 998470296  213 NAIGASKPSKES 224
Cdd:cd00063    78 NGGGESPPSESV 89

R-PTPc-C-1

cd14557

catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1; Receptor-type ...

989-1182

2.84e-16

Pssm-ID: 350405 [Multi-domain] Cd Length: 201 Bit Score: 78.72 E-value: 2.84e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPDTDEEQD-YGSFKVKPTGE 1064
Cdd:cd14557     1 YINASYIDGFKEPRKYIAAQGPKDETVDDFWRMIWEQKSTVIVMVTRCEEGNRnkcAQYWPSMEEGSRaFGDVVVKINEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAPPVAEEKGALMPG-EGGGLPSRDFILQSTQDDYelacrlllcpGWPQSCSPLAKafeLVKEVGARQERdQNGPVVIV 1143
Cdd:cd14557    81 KICPDYIIRKLNINNKkEKGSGREVTHIQFTSWPDH----------GVPEDPHLLLK---LRRRVNAFNNF-FSGPIVVH 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 998470296 1144 DRYGGTEAATFCCLSALYRQLEREKCVDVYMY-AKLYHMR 1182
Cdd:cd14557   147 CSAGVGRTGTYIGIDAMLEGLEAEGRVDVYGYvVKLRRQR 186

PTPc-N1

cd14608

catalytic domain of tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein ...

945-1197

3.12e-16

Pssm-ID: 350456 [Multi-domain] Cd Length: 277 Bit Score: 80.45 E-value: 3.12e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  945 KAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVhitpKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWD 1024
Cdd:cd14608    11 EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRI----KLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1025 HNSQTIVVLSVVDEK---EHPQFWPDTDEEQ---DYGSFKVKPTGESVAPPVAeekgalmpgeggglpSRDFILQ--STQ 1096
Cdd:cd14608    87 QKSRGVVMLNRVMEKgslKCAQYWPQKEEKEmifEDTNLKLTLISEDIKSYYT---------------VRQLELEnlTTQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1097 DDYE-LACRLLLCP--GWPQSCSPLAKAFELVKEVGARQErdQNGPVVIVDRYGGTEAATFCCL-SALYRQLEREKCVDV 1172
Cdd:cd14608   152 ETREiLHFHYTTWPdfGVPESPASFLNFLFKVRESGSLSP--EHGPVVVHCSAGIGRSGTFCLAdTCLLLMDKRKDPSSV 229

                         250       260
                  ....*....|....*....|....*..
gi 998470296 1173 YMYAKLYHMR--RPGIWKSQDDFLFLY 1197
Cdd:cd14608   230 DIKKVLLEMRkfRMGLIQTADQLRFSY 256

PHA02747

protein tyrosine phosphatase; Provisional

953-1196

3.44e-16

protein tyrosine phosphatase; Provisional

Pssm-ID: 165114 [Multi-domain] Cd Length: 312 Bit Score: 81.20 E-value: 3.44e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  953 SAVKPCNKAKNRSLNLIPIESHRVHITPKPGiDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVV 1032
Cdd:PHA02747   45 NFEKPENQPKNRYWDIPCWDHNRVILDSGGG-STSDYIHANWIDGFEDDKKFIATQGPFAETCADFWKAVWQEHCSIIVM 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1033 LS----VVDEKEHPQFW-PDTDEEQDYGSFKVKPTGESVAPPVAeekgalmpgegggLPSRDFILQSTQDDYELAcrLLL 1107
Cdd:PHA02747  124 LTptkgTNGEEKCYQYWcLNEDGNIDMEDFRIETLKTSVRAKYI-------------LTLIEITDKILKDSRKIS--HFQ 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1108 CPGWPQSCSP--------LAKAFELVKEVGARQERDQNG---PVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYA 1176
Cdd:PHA02747  189 CSEWFEDETPsdhpdfikFIKIIDINRKKSGKLFNPKDAllcPIVVHCSDGVGKTGIFCAVDICLNQLVKRKAICLAKTA 268

                         250       260
                  ....*....|....*....|.
gi 998470296 1177 -KLYHMRRPGIwKSQDDFLFL 1196
Cdd:PHA02747  269 eKIREQRHAGI-MNFDDYLFI 288

R-PTPc-typeIIb-1

cd14555

catalytic domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, ...

989-1197

3.52e-16

Pssm-ID: 350403 [Multi-domain] Cd Length: 204 Bit Score: 78.42 E-value: 3.52e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVV---LSVVDEKEHPQFWPDTDEEqdYGSFKV-----K 1060
Cdd:cd14555     1 YINANYIDGYHRPNHYIATQGPMQETVYDFWRMVWQENSASIVMvtnLVEVGRVKCSRYWPDDTEV--YGDIKVtlvetE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1061 PTGESVAppvaeekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKA--FELVKEVGARQERDQnG 1138
Cdd:cd14555    79 PLAEYVV--------------------RTFALERRGYHEIREVRQFHFTGWPDHGVPYHATglLGFIRRVKASNPPSA-G 137

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296 1139 PVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14555   138 PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKELRSRRVNMVQTEEQYIFIH 196

PTPc-N5

cd14613

catalytic domain of tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein ...

962-1197

3.93e-16

Pssm-ID: 350461 [Multi-domain] Cd Length: 258 Bit Score: 79.91 E-value: 3.93e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  962 KNRSLNLIPIESHRVH-ITPKPGIDGSDYINATFLQGFN-RLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK 1039
Cdd:cd14613    28 KNRYKTILPNPHSRVClTSPDQDDPLSSYINANYIRGYGgEEKVYIATQGPTVNTVGDFWRMVWQERSPIIVMITNIEEM 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 EHP--QFWPdtDEEQDYGSFKVkptgeSVAPPVAEEKGALmpgeggglpsRDFILQSTQDDYELacRLLLCPGWPQSCSP 1117
Cdd:cd14613   108 NEKctEYWP--EEQVTYEGIEI-----TVKQVIHADDYRL----------RLITLKSGGEERGL--KHYWYTSWPDQKTP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1118 --LAKAFELVKEV--GARQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDF 1193
Cdd:cd14613   169 dnAPPLLQLVQEVeeARQQAEPNCGPVIVHCSAGIGRTGCFIATSICCKQLRNEGVVDILRTTCQLRLDRGGMIQTCEQY 248


                  ....
gi 998470296 1194 LFLY 1197
Cdd:cd14613   249 QFVH 252

R-PTPc-K-2

cd14636

PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2; Receptor-type ...

989-1197

4.17e-16

Pssm-ID: 350484 [Multi-domain] Cd Length: 206 Bit Score: 78.53 E-value: 4.17e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH-PQFWPDTDEEQdYGSFKVKPTGESVA 1067
Cdd:cd14636     1 YINAALMDSYRQPAAFIVTQHPLPNTVKDFWRLVYDYGCTSIVMLNEVDLAQGcPQYWPEEGMLR-YGPIQVECMSCSMD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1068 PPVAeekgalmpgeggglpSRDFI---LQSTQDDYeLACRLLLCPGWPQSCS-PLAKA--FELVKEVGARQER--DQNGP 1139
Cdd:cd14636    80 CDVI---------------SRIFRicnLTRPQEGY-LMVQQFQYLGWASHREvPGSKRsfLKLILQVEKWQEEcdEGEGR 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296 1140 VVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14636   144 TIIHCLNGGGRSGMFCAISIVCEMIKRQNVVDVFHAVKTLRNSKPNMVETPEQYRFCY 201

R-PTP-N2

cd14610

PTP-like domain of receptor-type tyrosine-protein phosphatase N2; Receptor-type ...

926-1195

7.23e-16

Pssm-ID: 350458 [Multi-domain] Cd Length: 283 Bit Score: 79.72 E-value: 7.23e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  926 DNEKSWSLLERQFKLVTMFKAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFN-RLREF 1004
Cdd:cd14610    11 DHLKNKNRLEKEWEALCAYQAEPNATNVAQREENVQKNRSLAVLPYDHSRIILKAENSHSHSDYINASPIMDHDpRNPAY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1005 IVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDTDEEQdYGSFKVKPTGESVAppvAEEkgalmpge 1081
Cdd:cd14610    91 IATQGPLPATVADFWQMVWESGCVVIVMLTPLAEngvKQCYHYWPDEGSNL-YHIYEVNLVSEHIW---CED-------- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1082 gggLPSRDFILQSTQDDYELACRLLLCPGW-----PQSCSPLakaFELVKEVGaRQERDQNGPVVIVDRYGGTEAATFCC 1156
Cdd:cd14610   159 ---FLVRSFYLKNLQTNETRTVTQFHFLSWndqgvPASTRSL---LDFRRKVN-KCYRGRSCPIIVHCSDGAGRSGTYIL 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 998470296 1157 LSALYRQLER-EKCVDVymYAKLYHMR--RPGIWKSQDDFLF 1195
Cdd:cd14610   232 IDMVLNKMAKgAKEIDI--AATLEHLRdqRPGMVQTKEQFEF 271

R-PTPc-K-1

cd14631

catalytic domain of receptor-type tyrosine-protein phosphatase K, repeat 1; Receptor-type ...

975-1197

8.59e-16

Pssm-ID: 350479 [Multi-domain] Cd Length: 218 Bit Score: 77.75 E-value: 8.59e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  975 RVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHP---QFWPDTDEE 1051
Cdd:cd14631     1 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVkcyKYWPDDTEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1052 qdYGSFKV-----KPTGESVAppvaeekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKA--FEL 1124
Cdd:cd14631    81 --YGDFKVtcvemEPLAEYVV--------------------RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATglLSF 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 998470296 1125 VKEVGARQERDQnGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14631   139 IRRVKLSNPPSA-GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIH 210

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

335-430

1.36e-15

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 73.30 E-value: 1.36e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  335 PSSPVNLTAVRVTDTTVRLKWREPVRPNGVLQGYHVYFQPSRNGSSQQQRKTVShpqPVEEYMLSGLKPFSFYDIWVKAF 414
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPG---SETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 998470296  415 TQQHLGESSNLLKVQT 430
Cdd:cd00063    78 NGGGESPPSESVTVTT 93

R-PTPc-U-2

cd14637

PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2; Receptor-type ...

989-1197

1.61e-15

Pssm-ID: 350485 [Multi-domain] Cd Length: 207 Bit Score: 76.87 E-value: 1.61e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHP----QFWPDTDEEQdYGSFKVkptgE 1064
Cdd:cd14637     1 YINAALTDSYTRSAAFIVTLHPLQNTTTDFWRLVYDYGCTSVVMLNQLNQSNSAwpclQYWPEPGLQQ-YGPMEV----E 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAPPVAEEkgalmpgegggLPSRDFILQST---QDDYELACRLLLCPGWPQSCSPLAK-AF-ELVKEVGARQERDQNGP 1139
Cdd:cd14637    76 FVSGSADED-----------IVTRLFRVQNItrlQEGHLMVRHFQFLRWSAYRDTPDSKkAFlHLLASVEKWQRESGEGR 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 998470296 1140 VVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14637   145 TVVHCLNGGGRSGTYCASAMILEMIRCHNIVDVFYAVKTLRNYKPNMVETLEQYRFCY 202

R-PTPc-U-1

cd14632

catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1; Receptor-type ...

989-1197

2.21e-15

Pssm-ID: 350480 [Multi-domain] Cd Length: 205 Bit Score: 76.24 E-value: 2.21e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE---KEHPQFWPDTDEEqdYGSFKVK-PTGE 1064
Cdd:cd14632     1 YINANYIDGYHRSNHFIATQGPKQEMVYDFWRMVWQEHCSSIVMITKLVEvgrVKCSKYWPDDSDT--YGDIKITlLKTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAPPVAeekgalmpgeggglpsRDFILQSTQDDYELACRLLLCPGWPQSCSPLAKA--FELVKEVGARQERDQnGPVVI 1142
Cdd:cd14632    79 TLAEYSV----------------RTFALERRGYSARHEVKQFHFTSWPEHGVPYHATglLAFIRRVKASTPPDA-GPVVV 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 998470296 1143 VDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd14632   142 HCSAGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRINMIQTEEQYIFIH 196

PTP_YopH-like

cd14559

YopH and related bacterial protein tyrosine phosphatases; Yersinia outer protein H (YopH) ...

689-885

3.24e-15

YopH and related bacterial protein tyrosine phosphatases; Yersinia outer protein H (YopH) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. YopH is an essential virulence determinant of the pathogenic bacterium by dephosphorylating several focal adhesion proteins including p130Cas in human epithelial cells, resulting in the disruption of focal adhesions and cell detachment from the extracellular matrix. It contains an N-terminal domain that contains signals required for TTSS-mediated delivery of YopH into host cells and a C-terminal catalytic PTP domain.

Pssm-ID: 350407 [Multi-domain] Cd Length: 227 Bit Score: 76.28 E-value: 3.24e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  689 INANYIDGYHKSRAfIGTQGPLPATFDDYWRMVWEQRVCIIIMITNLVERGRRKCDMYWpkEGTETYGIIQVKlvQEIVM 768
Cdd:cd14559    18 LNANRVQIGNKNVA-IACQYPKNEQLEDHLKMLADNRTPCLVVLASNKDIQRKGLPPYF--RQSGTYGSVTVK--SKKTG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  769 ATYTIRTFAIKNIKVKKKQASER-TVYQYHYTNWPDHG-VPDHPLPVLS--------------FVAKSSAANPPAAGPMI 832
Cdd:cd14559    93 KDELVDGLKADMYNLKITDGNKTiTIPVVHVTNWPDHTaISSEGLKELAdlvnksaeekrnfyKSKGSSAINDKNKLLPV 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 998470296  833 VHCSAGVGRTGTYIvldAMLRQMRQRQSVNVYGFLRHIRQQRN-YLVQTEEQYV 885
Cdd:cd14559   173 IHCRAGVGRTGQLA---AAMELNKSPNNLSVEDIVSDMRTSRNgKMVQKDEQLD 223

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

236-330

6.39e-15

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 71.37 E-value: 6.39e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  236 GKPTIVHAQNTSSSSVRIQWTAPArhTIHGEFEGYRITYRPRDrtQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVF 315
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKG--SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 998470296  316 NPAGRG-PAVVVPVMT 330
Cdd:cd00063    78 NGGGESpPSESVTVTT 93

fn3

Fibronectin type III domain;

236-322

1.21e-14

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.21e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   236 GKPTIVHAQNTSSSSVRIQWTAParHTIHGEFEGYRITYRPRDRTQEESREIILRDskQTQYTIRNLETFTQYLVSLQVF 315
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAV 76


                   ....*..
gi 998470296   316 NPAGRGP 322
Cdd:pfam00041   77 NGGGEGP 83

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

133-218

1.34e-14

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 70.34 E-value: 1.34e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    133 PDPPGIPIVVGFTSRSVDLSWTSSPNSHHSvilHYIIHIRIGEKGDWDTMNKVMTSDNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 998470296    213 NAIGAS 218
Cdd:smart00060   78 NGAGEG 83

R-PTPc-A-E-1

cd14551

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 1; ...

989-1198

1.37e-14

Pssm-ID: 350399 [Multi-domain] Cd Length: 202 Bit Score: 73.79 E-value: 1.37e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH---PQFWPDTDEEQdYGSFKVKptges 1065
Cdd:cd14551     1 YINASYIDGYQEKNKFIAAQGPKDETVNDFWRMIWEQGSATIVMVTNLKERKEkkcSQYWPDQGCWT-YGNLRVR----- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1066 vappvAEEKGALMpgeggGLPSRDFILQSTQDDY-ELACRL---LLCPGWPQ---SCSPLAKAFELVKEVGARQERDqnG 1138
Cdd:cd14551    75 -----VEDTVVLV-----DYTTRKFCIQKVNRGIgEKRVRLvtqFHFTSWPDfgvPFTPIGMLKFLKKVKSANPPRA--G 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1139 PVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAKLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:cd14551   143 PIVVHCSAGVGRTGTFIVIDAMLDMMHAEGKVDVFGFVSRIRQQRSQMVQTDMQYVFIYQ 202

PTP_fungal

cd18533

fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae ...

989-1197

1.40e-14

Pssm-ID: 350509 [Multi-domain] Cd Length: 212 Bit Score: 74.21 E-value: 1.40e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQ-GFNRLREFIVTQHPLMDTMADFWQMVWdhNSQTIVVLSVVDEKEHP-----QFWPDTDEEQDYGSFKVKpt 1062
Cdd:cd18533     1 YINASYITlPGTSSKRYIATQGPLPATIGDFWKMIW--QNNVGVIVMLTPLVENGrekcdQYWPSGEYEGEYGDLTVE-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1063 gesvappVAEEKGalmpGEGGGLPSRDFILQStqDDYELACRL-LLCPGWPQSCSPLAKA--FELVKEVGARQERDQNGP 1139
Cdd:cd18533    77 -------LVSEEE----NDDGGFIVREFELSK--EDGKVKKVYhIQYKSWPDFGVPDSPEdlLTLIKLKRELNDSASLDP 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 998470296 1140 VVIVD------RYGgteaaTFCCLSALYRQLER--------EKCVDVyMYAKLYHMR--RPGIWKSQDDFLFLY 1197
Cdd:cd18533   144 PIIVHcsagvgRTG-----TFIALDSLLDELKRglsdsqdlEDSEDP-VYEIVNQLRkqRMSMVQTLRQYIFLY 211

R-PTPc-R

cd14611

catalytic domain of receptor-type tyrosine-protein phosphatase R; Receptor-type ...

962-1197

1.88e-14

Pssm-ID: 350459 [Multi-domain] Cd Length: 226 Bit Score: 74.18 E-value: 1.88e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  962 KNRSLNLIPIESHRVHITPKPGIDG-SDYINATFLQGF-NRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK 1039
Cdd:cd14611     2 KNRYKTILPNPHSRVCLKPKNSNDSlSTYINANYIRGYgGKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1040 EHP--QFWPdtDEEQDYGsfKVKPTGESVAPPVAEEKGALMPGEGGGLPSRDFILQSTQDDYELacrlllcpgwPQSCSP 1117
Cdd:cd14611    82 NEKcvLYWP--EKRGIYG--KVEVLVNSVKECDNYTIRNLTLKQGSQSRSVKHYWYTSWPDHKT----------PDSAQP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1118 LAKAFELVKEvgARQERDQNGPVVI-----VDRYGGTEAATFCClsalyRQLEREKCVDVYMYAKLYHMRRPGIWKSQDD 1192
Cdd:cd14611   148 LLQLMLDVEE--DRLASPGRGPVVVhcsagIGRTGCFIATTIGC-----QQLKEEGVVDVLSIVCQLRVDRGGMVQTSEQ 220


                  ....*
gi 998470296 1193 FLFLY 1197
Cdd:cd14611   221 YEFVH 225

PTPc_motif

smart00404

Protein tyrosine phosphatase, catalytic domain motif;

1103-1198

2.68e-14

Protein tyrosine phosphatase, catalytic domain motif;

Pssm-ID: 214649 [Multi-domain] Cd Length: 105 Bit Score: 70.08 E-value: 2.68e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1103 CRLLLCPGW-----PQSCSPLAKAFELVKEVgaRQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLERE-KCVDVYMYA 1176
Cdd:smart00404    2 VKHYHYTGWpdhgvPESPDSILELLRAVKKN--LNQSESSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEaGEVDIFDTV 79

                            90       100
                    ....*....|....*....|..
gi 998470296   1177 KLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:smart00404   80 KELRSQRPGMVQTEEQYLFLYR 101

PTPc_DSPc

smart00012

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ...

1103-1198

2.68e-14

Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 70.08 E-value: 2.68e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   1103 CRLLLCPGW-----PQSCSPLAKAFELVKEVgaRQERDQNGPVVIVDRYGGTEAATFCCLSALYRQLERE-KCVDVYMYA 1176
Cdd:smart00012    2 VKHYHYTGWpdhgvPESPDSILELLRAVKKN--LNQSESSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEaGEVDIFDTV 79

                            90       100
                    ....*....|....*....|..
gi 998470296   1177 KLYHMRRPGIWKSQDDFLFLYR 1198
Cdd:smart00012   80 KELRSQRPGMVQTEEQYLFLYR 101

fn3

Fibronectin type III domain;

336-423

3.61e-14

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 68.98 E-value: 3.61e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   336 SSPVNLTAVRVTDTTVRLKWREPVRPNGVLQGYHVYFQPSRNGSSQQQRKTVSHPqpvEEYMLSGLKPFSFYDIWVKAFT 415
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTT---TSVTLTGLKPGTEYEVRVQAVN 77


                   ....*...
gi 998470296   416 QQHLGESS 423
Cdd:pfam00041   78 GGGEGPPS 85

PTPc-N13

cd14597

catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein ...

959-1048

3.64e-14

Pssm-ID: 350445 [Multi-domain] Cd Length: 234 Bit Score: 73.33 E-value: 3.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHItpkpGIDGsDYINATFLQGFNRLREF--IVTQHPLMDTMADFWQMVWDHNSQTIVVLS-- 1034
Cdd:cd14597     3 NRKKNRYKNILPYDTTRVPL----GDEG-GYINASFIKMPVGDEEFvyIACQGPLPTTVADFWQMVWEQKSTVIAMMTqe 77

                          90
                  ....*....|....*
gi 998470296 1035 VVDEKEHPQ-FWPDT 1048
Cdd:cd14597    78 VEGGKIKCQrYWPEI 92

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

236-321

5.03e-14

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 68.41 E-value: 5.03e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    236 GKPTIVHAQNTSSSSVRIQWTAPArhtiHGEFEGYRITYRPRDRTQEESREIILRDSKQTQYTIRNLETFTQYLVSLQVF 315
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP----DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 998470296    316 NPAGRG 321
Cdd:smart00060   78 NGAGEG 83

PTPc-N1_2

cd14545

catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2; ...

962-1060

5.20e-14

Pssm-ID: 350393 [Multi-domain] Cd Length: 231 Bit Score: 72.81 E-value: 5.20e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  962 KNRSLNLIPIESHRVHITPkpgiDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEH 1041
Cdd:cd14545     3 RYRDRDPYDHDRSRVKLKQ----GDNDYINASLVEVEEAKRSYILTQGPLPNTSGHFWQMVWEQNSKAVIMLNKLMEKGQ 78

                          90       100
                  ....*....|....*....|....*.
gi 998470296 1042 P---QFWPdTDEEQDY----GSFKVK 1060
Cdd:cd14545    79 IkcaQYWP-QGEGNAMifedTGLKVT 103

PTPc-N2

cd14607

catalytic domain of tyrosine-protein phosphatase non-receptor type 2; Tyrosine-protein ...

945-1197

8.86e-14

Pssm-ID: 350455 [Multi-domain] Cd Length: 257 Bit Score: 72.69 E-value: 8.86e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  945 KAKDFNVVSAVKPCNKAKNRSLNLIPIESHRVHITPKPgidgSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWD 1024
Cdd:cd14607    10 ESHDYPHRVAKYPENRNRNRYRDVSPYDHSRVKLQNTE----NDYINASLVVIEEAQRSYILTQGPLPNTCCHFWLMVWQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1025 HNSQTIVVLSVVDEKEH---PQFWPDTDEE----QDYGsFKVKPTGESVAPPVAEEKGALMPGEGGGLPSRDFILQSTQD 1097
Cdd:cd14607    86 QKTKAVVMLNRIVEKDSvkcAQYWPTDEEEvlsfKETG-FSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1098 DYelacrlllcpGWPQSCSPLAKAFELVKEVGARQErdQNGPVVIVDRYGGTEAATFCCLSALYRQLEREKCVDVYMYAK 1177
Cdd:cd14607   165 DF----------GVPESPASFLNFLFKVRESGSLSP--EHGPAVVHCSAGIGRSGTFSLVDTCLVLMEKKDPDSVDIKQV 232

                         250       260
                  ....*....|....*....|..
gi 998470296 1178 LYHMR--RPGIWKSQDDFLFLY 1197
Cdd:cd14607   233 LLDMRkyRMGLIQTPDQLRFSY 254

PHA02742

protein tyrosine phosphatase; Provisional

959-1060

9.59e-14

protein tyrosine phosphatase; Provisional

Pssm-ID: 165109 [Multi-domain] Cd Length: 303 Bit Score: 73.50 E-value: 9.59e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVHITPKPGidGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:PHA02742   52 NMKKCRYPDAPCFDRNRVILKIEDG--GDDFINASYVDGHNAKGRFICTQAPLEETALDFWQAIFQDQVRVIVMITKIME 129

                          90       100
                  ....*....|....*....|....*.
gi 998470296 1039 KE----HPQFWPDTDEEQDYGSFKVK 1060
Cdd:PHA02742  130 DGkeacYPYWMPHERGKATHGEFKIK 155

FN3

Fibronectin type 3 domain [General function prediction only];

292-510

1.23e-13

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 75.42 E-value: 1.23e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  292 SKQTQYTIRNLETFTQYLVSLQVFNPAGRG-PAVVVPVMTDEGVPSSPVNLTAVRVTDTTVRLKWREPvrPNGVLQGYHV 370
Cdd:COG3401   189 STTLVDGGGDIEPGTTYYYRVAATDTGGESaPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV--TESDATGYRV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  371 YfqpsRNGSSQQQRKTVSHPQpVEEYMLSGLKPFSFYDIWVKAFTQQHL-GESSNLLKVQTDVQGPSAPVIVNLTCQSLD 449
Cdd:COG3401   267 Y----RSNSGDGPFTKVATVT-TTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSS 341

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  450 SLFLQWErpQTYYNRVDYYFVHYRSEEAWSFEEIAMAANDrlehVMFI-PNLTANTLYEVKV 510
Cdd:COG3401   342 SITLSWT--ASSDADVTGYNVYRSTSGGGTYTKIAETVTT----TSYTdTGLTPGTTYYYKV 397

R-PTP-N-N2

cd14546

PTP-like domain of receptor-type tyrosine-protein phosphatase-like N and N2; Receptor-type ...

989-1197

2.32e-13

Pssm-ID: 350394 [Multi-domain] Cd Length: 208 Bit Score: 70.55 E-value: 2.32e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFN-RLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHPQ---FWPDTDEEQdYGSFKVKPTGE 1064
Cdd:cd14546     1 YINASTIYDHDpRNPAYIATQGPLPHTIADFWQMIWEQGCVVIVMLTRLQENGVKQcarYWPEEGSEV-YHIYEVHLVSE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1065 SVAppvaeekgalmpgeggglpSRDFILQS-------TQDDYELACRLLLcpGWPQSCSPL-AKAF-ELVKEVGaRQERD 1135
Cdd:cd14546    80 HIW-------------------CDDYLVRSfylknlqTSETRTVTQFHFL--SWPDEGIPAsAKPLlEFRRKVN-KSYRG 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998470296 1136 QNGPVVIVDRYGGTEAATFCCLS-ALYRQLEREKCVDVymYAKLYHMR--RPGIWKSQDDFLFLY 1197
Cdd:cd14546   138 RSCPIVVHCSDGAGRTGTYILIDmVLNRMAKGAKEIDI--AATLEHLRdqRPGMVKTKDQFEFVL 200

PTPc-N14

cd14599

catalytic domain of tyrosine-protein phosphatase non-receptor type 14; Tyrosine-protein ...

953-1059

4.20e-13

Pssm-ID: 350447 [Multi-domain] Cd Length: 287 Bit Score: 71.18 E-value: 4.20e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  953 SAVKPCNKAKNRSLNLIPIESHRVHITPKPGiDGSDYINATFLQGFNRLRE--FIVTQHPLMDTMADFWQMVWDHNSQTI 1030
Cdd:cd14599    32 TATLPENAERNRIREVVPYEENRVELVPTKE-NNTGYINASHIKVTVGGEEwhYIATQGPLPHTCHDFWQMVWEQGVNVI 110

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 998470296 1031 VVLSVVDE----KEHpQFWPDTDEEQD---YGSFKV 1059
Cdd:cd14599   111 AMVTAEEEggrsKSH-RYWPKLGSKHSsatYGKFKV 145

PTPc-N22

cd14602

catalytic domain of tyrosine-protein phosphatase non-receptor type 22; Tyrosine-protein ...

962-1197

5.36e-13

Pssm-ID: 350450 [Multi-domain] Cd Length: 234 Bit Score: 69.87 E-value: 5.36e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  962 KNRSLNLIPIESHRVHITPKPGIDGSDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE--- 1038
Cdd:cd14602     1 KNRYKDILPYDHSRVELSLITSDEDSDYINANFIKGVYGPRAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEFEmgk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1039 KEHPQFWPDTDEEQ-DYGSFKVKPTGEsvappvaEEKGalmpgeggglpsrDFILQSTQDDYELACRLLL---CPGWPQS 1114
Cdd:cd14602    81 KKCERYWAEPGEMQlEFGPFSVTCEAE-------KRKS-------------DYIIRTLKVKFNSETRTIYqfhYKNWPDH 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1115 CSP--LAKAFELVKEVGARQErDQNGPVVIVDRYGGTEAATFCCLSALYRQLER---EKCVDVYMYAKLYHMRRPGIWKS 1189
Cdd:cd14602   141 DVPssIDPILELIWDVRCYQE-DDSVPICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIQEMRTQRPSLVQT 219


                  ....*...
gi 998470296 1190 QDDFLFLY 1197
Cdd:cd14602   220 KEQYELVY 227

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

335-420

1.32e-12

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 64.56 E-value: 1.32e-12

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    335 PSSPVNLTAVRVTDTTVRLKWREPVRPNGVlqGYHVYFQPSRNGSSQQQrKTVSHPQPVEEYMLSGLKPFSFYDIWVKAF 414
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 998470296    415 TQQHLG 420
Cdd:smart00060   78 NGAGEG 83

PHA02738

hypothetical protein; Provisional

959-1062

1.59e-12

hypothetical protein; Provisional

Pssm-ID: 222923 [Multi-domain] Cd Length: 320 Bit Score: 69.95 E-value: 1.59e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  959 NKAKNRSLNLIPIESHRVhITPKPGIDGsDYINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE 1038
Cdd:PHA02738   49 NRKLNRYLDAVCFDHSRV-ILPAERNRG-DYINANYVDGFEYKKKFICGQAPTRQTCYDFYRMLWMEHVQIIVMLCKKKE 126

                          90       100
                  ....*....|....*....|....*...
gi 998470296 1039 KEHPQ---FWPDTDEEQ-DYGSFKVKPT 1062
Cdd:PHA02738  127 NGREKcfpYWSDVEQGSiRFGKFKITTT 154

PTPc_plant_PTP1

cd17658

protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs; Arabidopsis ...

989-1197

1.81e-12

Pssm-ID: 350496 [Multi-domain] Cd Length: 206 Bit Score: 67.87 E-value: 1.81e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQ--GFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVL-SVVD----EKEHPQFWPDTDEEQDYGSFKVKP 1061
Cdd:cd17658     1 YINASLVEtpASESLPKFIATQGPLPHTFEDFWEMVIQQRCPVIIMLtRLVDnystAKCADYFPAEENESREFGRISVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1062 TGESVAppvaeekgalmpgeGGGLPSRDFILQSTQDDYELACRL-LLCPGWPQSCSPLAKAF--ELVKEVgaRQERDQNG 1138
Cdd:cd17658    81 KKLKHS--------------QHSITLRVLEVQYIESEEPPLSVLhIQYPEWPDHGVPKDTRSvrELLKRL--YGIPPSAG 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998470296 1139 PVVIVDRYGGTEAATFCCLS-ALYRQLERE-KCVDVYMYAKLYHMRRPGIWKSQDDFLFLY 1197
Cdd:cd17658   145 PIVVHCSAGIGRTGAYCTIHnTIRRILEGDmSAVDLSKTVRKFRSQRIGMVQTQDQYIFCY 205

fn3

Fibronectin type III domain;

134-221

7.62e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 7.62e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296   134 DPPGIPIVVGFTSRSVDLSWTSsPNSHHSVILHYIIHIRigEKGDWDTMNKVMTSDNSTNFQVIGLKPFTVYSFRVLAVN 213
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP-PPDGNGPITGYEVEYR--PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*...
gi 998470296   214 AIGASKPS 221
Cdd:pfam00041   78 GGGEGPPS 85

PTPc-N22_18_12

cd14542

catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; ...

989-1065

5.06e-11

Pssm-ID: 350390 [Multi-domain] Cd Length: 202 Bit Score: 63.60 E-value: 5.06e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVlsVVDEKEH-----PQFWPDTDEEQ-DYGSFKVKPT 1062
Cdd:cd14542     1 YINANFIKGVSGSKAYIATQGPLPNTVLDFWRMIWEYNVQVIVM--ACREFEMgkkkcERYWPEEGEEQlQFGPFKISLE 78


                  ...
gi 998470296 1063 GES 1065
Cdd:cd14542    79 KEK 81

PTPc-N4

cd14601

catalytic domain of tyrosine-protein phosphatase non-receptor type 4; Tyrosine-protein ...

988-1059

7.68e-11

Pssm-ID: 350449 [Multi-domain] Cd Length: 212 Bit Score: 63.04 E-value: 7.68e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 998470296  988 DYINATFLQ----GFNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEK---EHPQFWPDTDEEQDYGSFKV 1059
Cdd:cd14601     1 DYINANYINmeipSSSIINRYIACQGPLPNTCSDFWQMTWEQGSSMVVMLTTQVERgrvKCHQYWPEPSGSSSYGGFQV 79

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

435-511

9.38e-10

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 9.38e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296  435 PSAPVIVNLTCQSLDSLFLQWERPQTYYNRVDYYFVHYRSEEAWSFEEIAMAANDRLEHVmfIPNLTANTLYEVKVQ 511
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYT--LTGLKPGTEYEFRVR 75

PTPc-N21_14

cd14540

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

989-1059

1.72e-09

Pssm-ID: 350388 [Multi-domain] Cd Length: 219 Bit Score: 59.39 E-value: 1.72e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINA---TFLQGfNRLREFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDEKEHP---QFWPDTDEEQD---YGSFKV 1059
Cdd:cd14540     1 YINAshiTATVG-GKQRFYIAAQGPLQNTVGDFWQMVWEQGVYLVVMVTAEEEGGREkcfRYWPTLGGEHDaltFGEYKV 79

FN3

Fibronectin type 3 domain [General function prediction only];

133-280

2.83e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 61.17 E-value: 2.83e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  133 PDPPGIPIVVGFTSRSVDLSWTSSPNSHhsvILHYIIHIRIGEKGDWDtmnKVMTSDNSTNFQVIGLKPFTVYSFRVLAV 212
Cdd:COG3401   327 PAAPSGLTATAVGSSSITLSWTASSDAD---VTGYNVYRSTSGGGTYT---KIAETVTTTSYTDTGLTPGTTYYYKVTAV 400

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  213 NAIG-ASKPSKESFYMVTLREVPEGK---PTIVHAQNTSSSSVRIQWTAPARHTIHGEFEGYRITYRPRDRT 280
Cdd:COG3401   401 DAAGnESAPSEEVSATTASAASGESLtasVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472

PTPc-N20

cd14596

catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein ...

989-1048

1.31e-08

Pssm-ID: 350444 [Multi-domain] Cd Length: 207 Bit Score: 56.29 E-value: 1.31e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998470296  989 YINATFLQGFNRLRE--FIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE----KEHpQFWPDT 1048
Cdd:cd14596     1 YINASYITMPVGEEElfYIATQGPLPSTIDDFWQMVWENRSDVIAMMTREVErgkvKCH-RYWPET 65

PTP-N23

cd14539

PTP-like domain of tyrosine-protein phosphatase non-receptor type 23; Tyrosine-protein ...

989-1165

1.75e-08

Pssm-ID: 350387 [Multi-domain] Cd Length: 205 Bit Score: 56.24 E-value: 1.75e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLR-EFIVTQHPLMDTMADFWQMVWDHNSQTIVVL---SVVDEKEHPQFWP-DTDEEQDYGSFKVKPTG 1063
Cdd:cd14539     1 YINASLIEDLTPYCpRFIATQAPLPGTAADFWLMVYEQQVSVIVMLvseQENEKQKVHRYWPtERGQALVYGAITVSLQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296 1064 ESVAPPVAEEkgalmpgeggglpsrdfILQSTQDDYELACRL--LLCPGWPQSCSPLAKA--FELVKEVGA--RQERDQN 1137
Cdd:cd14539    81 VRTTPTHVER-----------------IISIQHKDTRLSRSVvhLQFTTWPELGLPDSPNplLRFIEEVHShyLQQRSLQ 143

                         170       180       190
                  ....*....|....*....|....*....|...
gi 998470296 1138 GPVVI-----VDRYGgteaaTFCCLSALYRQLE 1165
Cdd:cd14539   144 TPIVVhcssgVGRTG-----AFCLLYAAVQEIE 171

PTPc-N20_13

cd14538

catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; ...

989-1059

2.34e-08

Pssm-ID: 350386 [Multi-domain] Cd Length: 207 Bit Score: 55.84 E-value: 2.34e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQ---GFNRLReFIVTQHPLMDTMADFWQMVWDHNSQTIVVLSVVDE----KEHpQFWPDTDEEQD--YGSFKV 1059
Cdd:cd14538     1 YINASHIRipvGGDTYH-YIACQGPLPNTTGDFWQMVWEQKSEVIAMVTQDVEggkvKCH-RYWPDSLNKPLicGGRLEV 78

PHA02740

protein tyrosine phosphatase; Provisional

954-1045

2.19e-07

protein tyrosine phosphatase; Provisional

Pssm-ID: 165107 [Multi-domain] Cd Length: 298 Bit Score: 54.20 E-value: 2.19e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  954 AVKPCNKAKNR------SLNLIPIESHRVHITPKPGIdgsdyINATFLQGFNRLREFIVTQHPLMDTMADFWQMVWDHNS 1027
Cdd:PHA02740   42 ANKACAQAENKakdenlALHITRLLHRRIKLFNDEKV-----LDARFVDGYDFEQKFICIINLCEDACDKFLQALSDNKV 116

                          90
                  ....*....|....*....
gi 998470296 1028 QTIVVLS-VVDEKEHPQFW 1045
Cdd:PHA02740  117 QIIVLISrHADKKCFNQFW 135

CDC14

COG2453

Protein-tyrosine phosphatase [Signal transduction mechanisms];

795-889

1.01e-06

Protein-tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 441989 [Multi-domain] Cd Length: 140 Bit Score: 49.58 E-value: 1.01e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  795 QYHYTNWPDHGVPDHP--LPVLSFVAKSSAANPPAAgpmiVHCSAGVGRTGTYIVLDAMLRQMRQRQSvnvygfLRHIRQ 872
Cdd:COG2453    49 EYLHLPIPDFGAPDDEqlQEAVDFIDEALREGKKVL----VHCRGGIGRTGTVAAAYLVLLGLSAEEA------LARVRA 118

                          90
                  ....*....|....*..
gi 998470296  873 QRNYLVQTEEQYVFIHD 889
Cdd:COG2453   119 ARPGAVETPAQRAFLER 135

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

435-511

1.05e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 1.05e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998470296    435 PSAPVIVNLTCQSLDSLFLQWERPQtyYNRVDYYFVHYRSEEAWSFEEIAMAANDRLEHVMFIPNLTANTLYEVKVQ 511
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

IG_like

smart00410

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

39-129

1.05e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.89 E-value: 1.05e-06

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296     39 VRVGGNATLACPdlPPGAGPPrHLLWWKEDRRLIeATRDRVTVAPDagprvsllPGSSALVFRSVLTQDSGEYQCVVNNR 118
Cdd:smart00410    6 VKEGESVTLSCE--ASGSPPP-EVTWYKQGGKLL-AESGRFSVSRS--------GSTSTLTISNVTPEDSGTYTCAATNS 73

                            90
                    ....*....|..
gi 998470296    119 QG-RRGLVRLFV 129
Cdd:smart00410   74 SGsASSGTTLTV 85

PTP_DSP_cys

cd14494

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This ...

829-889

1.45e-06

Pssm-ID: 350344 [Multi-domain] Cd Length: 113 Bit Score: 48.11 E-value: 1.45e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 998470296  829 GPMIVHCSAGVGRTGTYIVLDAMLRQMRqrqsvNVYGFLRHIRQQR-NYLVQTEEQYVFIHD 889
Cdd:cd14494    57 EPVLVHCKAGVGRTGTLVACYLVLLGGM-----SAEEAVRIVRLIRpGGIPQTIEQLDFLIK 113

PTPc-N21

cd14598

catalytic domain of tyrosine-protein phosphatase non-receptor type 21; Tyrosine-protein ...

989-1059

2.09e-06

Pssm-ID: 350446 [Multi-domain] Cd Length: 220 Bit Score: 50.36 E-value: 2.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296  989 YINATFLQGFNRLRE--FIVTQHPLMDTMADFWQMVWDhnsQTIVVLSVVDEKEHP------QFWPDTDEEQD---YGSF 1057
Cdd:cd14598     1 YINASHIKVTVGGKEwdYIATQGPLQNTCQDFWQMVWE---QGVAIIAMVTAEEEGgreksfRYWPRLGSRHNtvtYGRF 77


                  ..
gi 998470296 1058 KV 1059
Cdd:cd14598    78 KI 79

pfam00047

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...

37-118

6.22e-06

Pssm-ID: 395002 Cd Length: 86 Bit Score: 45.65 E-value: 6.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998470296    37 LFVRVGGNATLACpdLPPGAGPPRHLLWWKEDRRLIEATRDRVTVAPDagprvsllpGSSALVFRSVLTQDSGEYQCVVN 116
Cdd:pfam00047    6 VTVLEGDSATLTC--SASTGSPGPDVTWSKEGGTLIESLKVKHDNGRT---------TQSSLLISNVTKEDAGTYTCVVN 74


                   ..
gi 998470296   117 NR 118
Cdd:pfam00047   75 NP 76

fn3