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Conserved domains on  [gi|2033828793|dbj|GIR73111|]
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MAG: hypothetical protein CM15mP75_6230 [Flammeovirgaceae bacterium]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 11445445)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
12-90 1.69e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.42  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033828793  12 QNLRDYALADDKRSLEQLAERhSWIDLDNVGIFGHSGGGFMSTAALLTYPDFYDVACSSAGNHDNNIYN---KWWSETHN 88
Cdd:COG1506    67 GDWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYgttREYTERLM 145


                  ..
gi 2033828793  89 GV 90
Cdd:COG1506   146 GG 147
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
12-90 1.69e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.42  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033828793  12 QNLRDYALADDKRSLEQLAERhSWIDLDNVGIFGHSGGGFMSTAALLTYPDFYDVACSSAGNHDNNIYN---KWWSETHN 88
Cdd:COG1506    67 GDWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYgttREYTERLM 145


                  ..
gi 2033828793  89 GV 90
Cdd:COG1506   146 GG 147
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
2-76 9.39e-09

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 50.31  E-value: 9.39e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2033828793   2 RSKYYHTFGYQNLRDYALADDKRSLEQLAERHsWIDLDNVGIFGHSGGGFMSTAALLTYPDFYDVACSSAGNHDN 76
Cdd:pfam00326  28 YGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALNQRPDLFKAAVAHVPVVDW 101
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 37-73 1.99e-03

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 35.77  E-value: 1.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2033828793  37 DLDNVGIFGHSGGGfMSTAALLTYPDFYDV---ACSSAGN 73
Cdd:cd00312   174 DPDSVTIFGESAGG-ASVSLLLLSPDSKGLfhrAISQSGS 212
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
12-90 1.69e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.42  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033828793  12 QNLRDYALADDKRSLEQLAERhSWIDLDNVGIFGHSGGGFMSTAALLTYPDFYDVACSSAGNHDNNIYN---KWWSETHN 88
Cdd:COG1506    67 GDWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYgttREYTERLM 145


                  ..
gi 2033828793  89 GV 90
Cdd:COG1506   146 GG 147
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
2-76 9.39e-09

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 50.31  E-value: 9.39e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2033828793   2 RSKYYHTFGYQNLRDYALADDKRSLEQLAERHsWIDLDNVGIFGHSGGGFMSTAALLTYPDFYDVACSSAGNHDN 76
Cdd:pfam00326  28 YGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALNQRPDLFKAAVAHVPVVDW 101
YpfH COG0400
Predicted esterase [General function prediction only];
15-69 1.04e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 38.73  E-value: 1.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2033828793  15 RDYALADDKRSLEQL------AERHSWIDLDNVGIFGHSGGGFMSTAALLTYPDFYD--VACS 69
Cdd:COG0400    59 GREDEEGLAAAAEALaafideLEARYGIDPERIVLAGFSQGAAMALSLALRRPELLAgvVALS 121
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
36-71 4.80e-04

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 37.27  E-value: 4.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2033828793  36 IDLDNVGIFGHSGGGFMSTAALLTYPDFYD--VACSSA 71
Cdd:COG2819   127 TDPERTGLIGHSLGGLFSLYALLKYPDLFGryIAISPS 164
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 26-64 6.30e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 36.91  E-value: 6.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2033828793  26 LEQLAERHSwIDLDNVGIFGHSGGGFMSTAALLTYPDFY 64
Cdd:COG3509   122 VDDLAARYG-IDPKRVYVTGLSAGGAMAYRLACEYPDVF 159
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
20-58 1.99e-03

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 35.47  E-value: 1.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2033828793  20 ADDKRSLEQLAERHSW-------IDLDNVGIFGHSGGGFmsTAALL 58
Cdd:COG4188   126 LDLSFVLDQLLALNKSdpplagrLDLDRIGVIGHSLGGY--TALAL 169
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 37-73 1.99e-03

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 35.77  E-value: 1.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2033828793  37 DLDNVGIFGHSGGGfMSTAALLTYPDFYDV---ACSSAGN 73
Cdd:cd00312   174 DPDSVTIFGESAGG-ASVSLLLLSPDSKGLfhrAISQSGS 212
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 13-62 2.33e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 35.17  E-value: 2.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2033828793  13 NLRDYALADDKRSLEQLAERHswiDLDNVGIFGHSGGGFMSTAALLTYPD 62
Cdd:pfam00561  46 AQDDYRTDDLAEDLEYILEAL---GLEKVNLVGHSMGGLIALAYAAKYPD 92
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 15-62 2.79e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 34.98  E-value: 2.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2033828793  15 RDYALADDKRSLEQLAERhswIDLDNVGIFGHSGGGFMSTAALLTYPD 62
Cdd:COG0596    68 GGYTLDDLADDLAALLDA---LGLERVVLVGHSMGGMVALELAARHPE 112
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
15-63 3.44e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 34.56  E-value: 3.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2033828793  15 RDYALADDKRSLEQLAeRHSWIDLDNVGIFGHSGGGFMSTAALLTYPDF 63
Cdd:COG0412    86 PELLAADLRAALDWLK-AQPEVDAGRVGVVGFCFGGGLALLAAARGPDL 133
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
39-61 6.87e-03

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 34.09  E-value: 6.87e-03
                          10        20
                  ....*....|....*....|...
gi 2033828793  39 DNVGIFGHSGGGfMSTAALLTYP 61
Cdd:COG2272   191 DNVTIFGESAGA-ASVAALLASP 212
COG4099 COG4099
Predicted peptidase [General function prediction only];
26-73 8.89e-03

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 33.40  E-value: 8.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2033828793  26 LEQLAERHSwIDLDNVGIFGHSGGGFMSTAALLTYPDFYD--VACSSAGN 73
Cdd:COG4099   113 LDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAaaVPICGGGD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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