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Conserved domains on  [gi|1903843085|dbj|GHD04660|]
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transcriptional regulator [Streptomyces violarus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-81 3.88e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.61  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903843085   1 MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSELMREVSDELALAELA 80
Cdd:COG1396     1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLS 80


                  .
gi 1903843085  81 Q 81
Cdd:COG1396    81 E 81
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-81 3.88e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.61  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903843085   1 MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSELMREVSDELALAELA 80
Cdd:COG1396     1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLS 80


                  .
gi 1903843085  81 Q 81
Cdd:COG1396    81 E 81
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-66 1.29e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.81  E-value: 1.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1903843085   22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:smart00530  12 TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 22-66 7.14e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 37.92  E-value: 7.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:cd00093    14 TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 22-66 1.15e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.52  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:pfam01381  11 SQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 22-82 3.86e-03

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 34.73  E-value: 3.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDV------RMSELMREVSDELALAELAQS 82
Cdd:PRK13890   20 TKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETplplllESTDLDKEALDALAGGKAPRS 86
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-81 3.88e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 49.61  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1903843085   1 MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSELMREVSDELALAELA 80
Cdd:COG1396     1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLS 80


                  .
gi 1903843085  81 Q 81
Cdd:COG1396    81 E 81
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-66 1.29e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.81  E-value: 1.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1903843085   22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:smart00530  12 TQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 22-66 7.14e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 37.92  E-value: 7.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:cd00093    14 TQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 22-66 1.15e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.52  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEL 66
Cdd:pfam01381  11 SQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 22-65 9.28e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 35.30  E-value: 9.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSE 65
Cdd:COG1813    27 SQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 22-82 3.86e-03

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 34.73  E-value: 3.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1903843085  22 TLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDV------RMSELMREVSDELALAELAQS 82
Cdd:PRK13890   20 TKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETplplllESTDLDKEALDALAGGKAPRS 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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