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Conserved domains on  [gi|1902505929|dbj|GGO21053|]
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SLC13 family permease [Deinococcus humi]

Protein Classification

SLC13 family permease( domain architecture ID 10100032)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-590 7.36e-65

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


:

Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 217.07  E-value: 7.36e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   9 FATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRG-LSRVG 87
Cdd:cd01115     1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKlLKRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  88 NGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIISNLRRDL 167
Cdd:cd01115    81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 168 LGEPYGMFSFTAVGGAVAVAGVAYLVVFgwrllpqrvsgenradlyrmadymtevrlpagsalagqrvmdlgkvegvqvv 247
Cdd:cd01115   161 GGQGFSFFEFTPIGLPLLIIGLLYLWFI---------------------------------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 248 slvrgesqrpFPTPFTVLqpedVLIVEANAARLTELVedgqltlvgnekitpeqlasddvrlAEVVVTALSPIVgqsavs 327
Cdd:cd01115   189 ----------FRLAVLII----TIVLLAALAAITGLL-------------------------PVSVAIAIGAIV------ 223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 328 lnlrqrfninliavsrqgqrlrerlvnarfkagdvllmhgphnsieeaMNTLGCLPLRErpldmvpagqtrkmlltggif 407
Cdd:cd01115   224 ------------------------------------------------LVFGGVLLTKE--------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 408 lvaivaatlnllpvavsftaaatlmlllrlinlrdVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAADWPV 487
Cdd:cd01115   235 -----------------------------------DYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPP 279

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 488 MAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSAFLTPIGHQSNTLVMGPGGYKFSDY 567
Cdd:cd01115   280 FAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDF 359

                         570       580
                  ....*....|....*....|...
gi 1902505929 568 WKVGLPLEIIVVAVGAPVIALVW 590
Cdd:cd01115   360 AKVGLPLSILSLVVSVTMIPLIW 382
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 308-379 4.25e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 55.31  E-value: 4.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1902505929 308 RLAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERLVNARFKAGDVLLMHGPHNSIEEAMNTL 379
Cdd:COG0490    69 AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 219-285 6.56e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


:

Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.83  E-value: 6.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1902505929 219 MTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGEsQRPFPTPFTVLQPEDVLIVEANAARLTELVE 285
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNlpERFGVRIVAIRRGG-RLIIPSGDTVLEAGDRLLVIGTPDDLAALRE 68
 
Name Accession Description Interval E-value
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-590 7.36e-65

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 217.07  E-value: 7.36e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   9 FATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRG-LSRVG 87
Cdd:cd01115     1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKlLKRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  88 NGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIISNLRRDL 167
Cdd:cd01115    81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 168 LGEPYGMFSFTAVGGAVAVAGVAYLVVFgwrllpqrvsgenradlyrmadymtevrlpagsalagqrvmdlgkvegvqvv 247
Cdd:cd01115   161 GGQGFSFFEFTPIGLPLLIIGLLYLWFI---------------------------------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 248 slvrgesqrpFPTPFTVLqpedVLIVEANAARLTELVedgqltlvgnekitpeqlasddvrlAEVVVTALSPIVgqsavs 327
Cdd:cd01115   189 ----------FRLAVLII----TIVLLAALAAITGLL-------------------------PVSVAIAIGAIV------ 223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 328 lnlrqrfninliavsrqgqrlrerlvnarfkagdvllmhgphnsieeaMNTLGCLPLRErpldmvpagqtrkmlltggif 407
Cdd:cd01115   224 ------------------------------------------------LVFGGVLLTKE--------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 408 lvaivaatlnllpvavsftaaatlmlllrlinlrdVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAADWPV 487
Cdd:cd01115   235 -----------------------------------DYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPP 279

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 488 MAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSAFLTPIGHQSNTLVMGPGGYKFSDY 567
Cdd:cd01115   280 FAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDF 359

                         570       580
                  ....*....|....*....|...
gi 1902505929 568 WKVGLPLEIIVVAVGAPVIALVW 590
Cdd:cd01115   360 AKVGLPLSILSLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-592 1.84e-56

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 194.22  E-value: 1.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  61 AAVLVISQALQKTGLVNVLVRG-LSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAG-----RSASS 134
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLlLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGsekrsKFGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 135 LLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEPYGMFSFTAVGGAVAVAGVAYLVVFGWRLLPQRVsgenradlyr 214
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEI---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 215 madymteVRLPAGSALAGQRVMDLGKVegvqvvslvrgesqrpfptpftvlqpedvliveanaarltelvedgqltlvgn 294
Cdd:COG0471   151 -------KEVPGSKEVIREELAELGPL----------------------------------------------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 295 ekitpeqlasddvrlaevvvtalspivgqsavslnlrqrfninliavsrqgqrlrerlvnarfkagdvllmhgphnsiee 374
Cdd:COG0471       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 375 amntlgclplrerpldmvpagqTRKMLLTGGIFLVAIVAATLN---LLPVAVSFTAAATLMLLLRLINLRDVYESIEWPI 451
Cdd:COG0471   171 ----------------------SRREKIALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGV 228

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 452 LVLLATLIPVGAALSSTGGAKLIAEGVLGVAADWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDA 531
Cdd:COG0471   229 LLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLP 308

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1902505929 532 FLMAVTLAASSAFLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVWGL 592
Cdd:COG0471   309 LALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
CitMHS pfam03600
Citrate transporter;
16-214 8.01e-32

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 125.89  E-value: 8.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  16 LVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNG-MTAQI 94
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGkPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  95 LVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEpYGM 174
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD-FGF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1902505929 175 FSFTAVGGAVAVAGVAYLVVFGWRLLPQRVSGENRADLYR 214
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELR 199
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 445-590 3.02e-11

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 65.83  E-value: 3.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 445 ESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAA-DWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQ 523
Cdd:TIGR00785 297 NKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDgLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS 376

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1902505929 524 GLDANPDAFLMAVTLAAS-SAFLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVW 590
Cdd:TIGR00785 377 AQGIPLELLALALALSASlMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 308-379 4.25e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 55.31  E-value: 4.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1902505929 308 RLAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERLVNARFKAGDVLLMHGPHNSIEEAMNTL 379
Cdd:COG0490    69 AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 309-379 3.25e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.69  E-value: 3.25e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1902505929 309 LAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERlVNARFKAGDVLLMHGPHNSIEEAMNTL 379
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS-GDTVLEAGDRLLVIGTPDDLAALRELL 70
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 219-285 6.56e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.83  E-value: 6.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1902505929 219 MTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGEsQRPFPTPFTVLQPEDVLIVEANAARLTELVE 285
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNlpERFGVRIVAIRRGG-RLIIPSGDTVLEAGDRLLVIGTPDDLAALRE 68
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 198-285 9.53e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 45.68  E-value: 9.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 198 RLLPQRVSGENRADLYRMADYMTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGESQRPFPTPFTVLQPEDVLIVEA 275
Cdd:COG0490    49 LLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNlrQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVG 128

                          90
                  ....*....|
gi 1902505929 276 NAARLTELVE 285
Cdd:COG0490   129 TREQLERLEE 138
PLN00136 PLN00136
silicon transporter; Provisional
 42-161 7.31e-04

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 42.29  E-value: 7.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  42 VVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVA 121
Cdd:PLN00136   51 VISPDDAYASIDLPILGLLFATMVVGSYLKNAGMFKHLGRLLAWRSQGGRDLLCRVCVVTALASALFTNDTCCVVLTEFV 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1902505929 122 ITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIIS 161
Cdd:PLN00136  131 LELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIA 170
 
Name Accession Description Interval E-value
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-590 7.36e-65

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 217.07  E-value: 7.36e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   9 FATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRG-LSRVG 87
Cdd:cd01115     1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKlLKRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  88 NGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIISNLRRDL 167
Cdd:cd01115    81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 168 LGEPYGMFSFTAVGGAVAVAGVAYLVVFgwrllpqrvsgenradlyrmadymtevrlpagsalagqrvmdlgkvegvqvv 247
Cdd:cd01115   161 GGQGFSFFEFTPIGLPLLIIGLLYLWFI---------------------------------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 248 slvrgesqrpFPTPFTVLqpedVLIVEANAARLTELVedgqltlvgnekitpeqlasddvrlAEVVVTALSPIVgqsavs 327
Cdd:cd01115   189 ----------FRLAVLII----TIVLLAALAAITGLL-------------------------PVSVAIAIGAIV------ 223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 328 lnlrqrfninliavsrqgqrlrerlvnarfkagdvllmhgphnsieeaMNTLGCLPLRErpldmvpagqtrkmlltggif 407
Cdd:cd01115   224 ------------------------------------------------LVFGGVLLTKE--------------------- 234

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 408 lvaivaatlnllpvavsftaaatlmlllrlinlrdVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAADWPV 487
Cdd:cd01115   235 -----------------------------------DYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPP 279

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 488 MAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSAFLTPIGHQSNTLVMGPGGYKFSDY 567
Cdd:cd01115   280 FAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDF 359

                         570       580
                  ....*....|....*....|...
gi 1902505929 568 WKVGLPLEIIVVAVGAPVIALVW 590
Cdd:cd01115   360 AKVGLPLSILSLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-592 1.84e-56

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 194.22  E-value: 1.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  61 AAVLVISQALQKTGLVNVLVRG-LSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAG-----RSASS 134
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLlLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGsekrsKFGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 135 LLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEPYGMFSFTAVGGAVAVAGVAYLVVFGWRLLPQRVsgenradlyr 214
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEI---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 215 madymteVRLPAGSALAGQRVMDLGKVegvqvvslvrgesqrpfptpftvlqpedvliveanaarltelvedgqltlvgn 294
Cdd:COG0471   151 -------KEVPGSKEVIREELAELGPL----------------------------------------------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 295 ekitpeqlasddvrlaevvvtalspivgqsavslnlrqrfninliavsrqgqrlrerlvnarfkagdvllmhgphnsiee 374
Cdd:COG0471       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 375 amntlgclplrerpldmvpagqTRKMLLTGGIFLVAIVAATLN---LLPVAVSFTAAATLMLLLRLINLRDVYESIEWPI 451
Cdd:COG0471   171 ----------------------SRREKIALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGV 228

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 452 LVLLATLIPVGAALSSTGGAKLIAEGVLGVAADWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDA 531
Cdd:COG0471   229 LLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLP 308

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1902505929 532 FLMAVTLAASSAFLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVWGL 592
Cdd:COG0471   309 LALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
CitMHS pfam03600
Citrate transporter;
16-214 8.01e-32

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 125.89  E-value: 8.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  16 LVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNG-MTAQI 94
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGkPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  95 LVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEpYGM 174
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD-FGF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1902505929 175 FSFTAVGGAVAVAGVAYLVVFGWRLLPQRVSGENRADLYR 214
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELR 199
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 16-586 1.54e-28

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 117.74  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  16 LVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQIL 95
Cdd:cd00625     1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  96 VMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASS-LLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEPYGM 174
Cdd:cd00625    81 LLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVpLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLAF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 175 FSFTAVGGAVAVAGVAYLVVFGWRLLPQRVSGENRADLYRMADYMTEVRLpagsalagqrvmdlgkvegvqvvslvrges 254
Cdd:cd00625   161 MAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLL------------------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 255 qrpfptpftvlqpedvliveanaarltelvedgqltlvgnekitpeqlasddvrlaevvvtalspivgqsavslnlrqrf 334
Cdd:cd00625       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 335 ninliavsrqgqrlrerlvnarfkagdvllmhgphnsieeamntlgclplrerpldmvpagqtrkmLLTGGIFLVAIVAA 414
Cdd:cd00625   211 ------------------------------------------------------------------LALLLLLLFVLLFF 224

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 415 TLNLLPVAVSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVaADWPVMAVLVVV 494
Cdd:cd00625   225 FLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVAL-VGLPPLAALLLI 303

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 495 MVLTMTLSDVINNAAAALITAPIA-----VTIAQGLDANPDAFLMAVTLAASSAFLTPIGHQSNTLVmgpgGYKFSDYWK 569
Cdd:cd00625   304 GLLSALLSNFISNVPTVALLLPIAaslapPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLK 379

                         570
                  ....*....|....*..
gi 1902505929 570 VGLPLEIIVVAVGAPVI 586
Cdd:cd00625   380 VGLPLTLLSLVVSLLYL 396
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
1-160 3.53e-16

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 80.58  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   1 MTTPQLLVFATLIGALVLFVWGKWRYD---VVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVN 77
Cdd:COG0471   170 LSRREKIALAIFALTVLLWITGSLHGIpiaVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  78 VLVRGLSRVGNGMTAQ--ILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMtTLIGTP 155
Cdd:COG0471   250 WLADALLPLLGGLSPLllLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFL-LPVGTP 328


                  ....*
gi 1902505929 156 PNLII 160
Cdd:COG0471   329 PNAIV 333
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
4-160 2.69e-13

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 72.08  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   4 PQLLVFATLIGALVLFVWGKWRYD--VVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVR 81
Cdd:COG1055     1 MMILALAIFVLTYLLIILEPRGLNraVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  82 GLSRVGNGMTAQILVM-CVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLII 160
Cdd:COG1055    81 KLARRAKGSPRRLLWLlGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMI 160
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 445-590 3.02e-11

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 65.83  E-value: 3.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 445 ESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAA-DWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQ 523
Cdd:TIGR00785 297 NKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDgLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS 376

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1902505929 524 GLDANPDAFLMAVTLAAS-SAFLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVW 590
Cdd:TIGR00785 377 AQGIPLELLALALALSASlMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
6-178 1.43e-10

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 63.61  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   6 LLVFATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSR 85
Cdd:COG1055   222 LLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLAS 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  86 -VGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSAssLLMPLAFASLLGGMTTLIGTPPNLI-ISNL 163
Cdd:COG1055   302 lTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIvLGIA 379

                         170
                  ....*....|....*
gi 1902505929 164 RRdlLGEPYGMFSFT 178
Cdd:COG1055   380 EK--KGIKISFGEFL 392
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 65-160 3.41e-10

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 62.27  E-value: 3.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  65 VISQALQKTGLVNVLVRGLSRVGNGM-TAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFAS 143
Cdd:cd01116    58 IIVSILSETGVFEYLAIWAVKISKGRpWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAA 137

                          90
                  ....*....|....*..
gi 1902505929 144 LLGGMTTLIGTPPNLII 160
Cdd:cd01116   138 NIGGAATLIGDPPNIMI 154
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 7-160 6.49e-10

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 61.06  E-value: 6.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   7 LVFATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGN-----EAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVR 81
Cdd:cd01115   189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGvlltkEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  82 GLSRVGNGMT--AQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTlIGTPPNLI 159
Cdd:cd01115   269 ALISLLGGLPpfAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLP-VGTPPNAI 347


                  .
gi 1902505929 160 I 160
Cdd:cd01115   348 V 348
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 5-160 2.66e-09

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 59.57  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   5 QLLVFATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGN---EAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVR 81
Cdd:cd00625   207 KFLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLdpeEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAE 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  82 GLSRV-GNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANragrsASSLLMPLAFASLLGGMTTLIGTPPNLII 160
Cdd:cd00625   287 LLVALvGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAP-----PEPAWLALALGSTLGGNLTLIGSLANLIP 361
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 308-379 4.25e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 55.31  E-value: 4.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1902505929 308 RLAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERLVNARFKAGDVLLMHGPHNSIEEAMNTL 379
Cdd:COG0490    69 AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
CitMHS pfam03600
Citrate transporter;
7-146 6.41e-09

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 57.71  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929   7 LVFATLIGALVLFVWGKWRYDVVGMLALLALTLTGVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRV 86
Cdd:pfam03600 207 LLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  87 GNGMTAQILVMcVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSAsslLMPLAFASLLG 146
Cdd:pfam03600 287 SGLLVALALIL-WLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD---PDPLAWALAVG 342
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
386-590 6.62e-09

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 58.22  E-value: 6.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 386 ERPLDMVPAGQTRKMLLTGGIFLVAIVAA--TLNLLPVAVSFTA--AATLMLLLRLINLRDVYESIEWPILVLLATLIPV 461
Cdd:COG1055   203 DLEDDPKEAIKDRRLLRISLLVLALLLVGfvLHSFLGLPPALIAllGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 462 GAALSSTGGAKLIAEgVLGVAADWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPD--AFLMAVTLA 539
Cdd:COG1055   283 VGGLENTGLLDLLAE-LLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLwlALALGATLG 361

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1902505929 540 ASsafLTPIGHQSNTLVMG-----PGGYKFSDYWKVGLPLEIIVVAVGAPVIALVW 590
Cdd:COG1055   362 GN---LTPIGSAANVIVLGiaekkGIKISFGEFLKVGLPLTLLTLLIALLYLLLLY 414
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 419-591 2.66e-08

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 56.10  E-value: 2.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 419 LPVAVSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTGGAKLIAeGVLGVAADWPVMAVLVVVMVLT 498
Cdd:cd00625     9 LPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLA-AKLARASKGSRRLLLLLMLLTA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 499 MTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSA-FLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEII 577
Cdd:cd00625    88 ALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALG 167

                         170
                  ....*....|....
gi 1902505929 578 VVAVGAPVIALVWG 591
Cdd:cd00625   168 LLLLLLGLLYLLFR 181
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 309-379 3.25e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.69  E-value: 3.25e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1902505929 309 LAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERlVNARFKAGDVLLMHGPHNSIEEAMNTL 379
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS-GDTVLEAGDRLLVIGTPDDLAALRELL 70
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 41-160 4.99e-08

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 55.36  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  41 GVVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPV 120
Cdd:cd01117    28 GVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLVLLSGILSALLTNDTACLVFTPI 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1902505929 121 AITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLII 160
Cdd:cd01117   108 VLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLI 147
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 11-160 1.28e-07

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 54.27  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  11 TLIGALVLFVWGKWRY---DVVGMLALLALTLTGVVKGNEAFRGFSEPAVIT-VAAVLVISQALQKTGLVNVLVRGLSRV 86
Cdd:TIGR00785 254 IFLLALLLWIFGGSLGinaSVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLIlFGGLIGLAGGLKKSGFIKWFSEKLVGI 333

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1902505929  87 GNGMTAQILVMCVVVA---VLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLII 160
Cdd:TIGR00785 334 LDGLSPTIAVLVLVVLfyiILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIA 410
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 219-285 6.56e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.83  E-value: 6.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1902505929 219 MTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGEsQRPFPTPFTVLQPEDVLIVEANAARLTELVE 285
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNlpERFGVRIVAIRRGG-RLIIPSGDTVLEAGDRLLVIGTPDDLAALRE 68
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
400-590 1.62e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 50.51  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 400 MLLTGGIFLVAIVAATL--NLLPVAVSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEG 477
Cdd:COG1055     2 MILALAIFVLTYLLIILepRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 478 VLGVAADwPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSA-FLTPIGHQSNTLV 556
Cdd:COG1055    82 LARRAKG-SPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMI 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1902505929 557 MGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVW 590
Cdd:COG1055   161 ASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF 194
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 229-380 2.97e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 50.12  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 229 ALAGQRVMDLGKV--EGVQVVSLVRGESQRPfPTPFTVLQPEDVLIVEANAARLTELVEdgqltLVGNEkITPEQLASDD 306
Cdd:COG2985   213 NLVGKTVAELEALlgTRVVISRIRRGGEIIV-PTPDTVLQEGDIVLVVGTREALEAAEA-----LLGEE-VDDSELLDSD 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1902505929 307 VRLAEVVVTAlSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLrerLVNA--RFKAGDVLLMHGPHNSIEEAMNTLG 380
Cdd:COG2985   286 LDVRRIVVTN-KEVAGKTLGELNLRNRFGVVITRVRRGGVEL---PATPdtVLQLGDRLTVVGPKEDVERVAKLLG 357
CitMHS pfam03600
Citrate transporter;
411-583 4.72e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 48.85  E-value: 4.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 411 IVAATLNLLPVAVSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVLGVAADwPVMAV 490
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGG-KPRRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 491 LVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAASSAF-LTPIGHQSNTLVMGPGGYKFSDYWK 569
Cdd:pfam03600  80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGtATPIGDPPNIIIASALGLSFGDFGF 159

                         170
                  ....*....|....
gi 1902505929 570 VGLPLEIIVVAVGA 583
Cdd:pfam03600 160 FMFPPVGVALLLVG 173
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 198-285 9.53e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 45.68  E-value: 9.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 198 RLLPQRVSGENRADLYRMADYMTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGESQRPFPTPFTVLQPEDVLIVEA 275
Cdd:COG0490    49 LLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNlrQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVG 128

                          90
                  ....*....|
gi 1902505929 276 NAARLTELVE 285
Cdd:COG0490   129 TREQLERLEE 138
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
50-381 1.01e-05

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 48.13  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  50 RGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQILVmcvvvAVLSSFMNNVGALAIMLPVAITLANRAG 129
Cdd:COG3273    55 RMDVLQLLARMSLLLAARALEEAELLAPVLGVVAAAVAISAAAGDIA-----KVVLEDIGLPEAMRAALPEAVETLVRAT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 130 RSASSLLMPLAFASLLGGMTTLIGTPP-NLIISNLRRDLLGEPYGMFSFTAVGGAVAVAGVAYLVVFGWRLLPQRVSGEN 208
Cdd:COG3273   130 VAASSALAGRTLLLILLETETGVRVIAiRRGDDWLLNPGPTTILRADDLVLLRGPEGGILEVYLAATGDLYERPRPPEDS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 209 RADLYRMADYMteVRLPAGSALAG-----------QRVMDLGKVEGVQVVSLVRGESQRPFPTPFTVLQPEDVLIVEANA 277
Cdd:COG3273   210 IVEMKNLSELA--VDLAYSSVLFDseelaeevrelEEEVDALKSRLEAWVLRAARRVDDPVALRGLLHLASSTEVISDAA 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 278 ARLTELVEDGqltlVGNEKITPEQLASDDVRLAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERLVNARF 357
Cdd:COG3273   288 LDIAEGVLRG----LEDHPVVAEAVRESDERIVRVTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRL 363

                         330       340
                  ....*....|....*....|....
gi 1902505929 358 KAGDVLLMHGPHNSIEEAMNTLGC 381
Cdd:COG3273   364 RAGDVLIVKGTREGLERLEELAGG 387
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 61-160 1.49e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 47.63  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  61 AAVLVISQALQKTGLVNVLVRGLSRVGNGMTA-QILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRAGRSASSLLMPL 139
Cdd:cd01116   277 AGLFVLVGGLEELGIIEWIAELLVGVILGRIAvAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWAL 356

                          90       100
                  ....*....|....*....|.
gi 1902505929 140 AFASLLGGMTTLIGTPPNLII 160
Cdd:cd01116   357 ALGACLGGNGTLIGASANVVA 377
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 43-176 2.11e-05

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 47.34  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  43 VKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQI--LVMCVVVAVLSSFMNNV-GALAIMLP 119
Cdd:TIGR00785  52 FKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgyFLVFLETLLAPMWPSNTaRAGGILLP 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1902505929 120 VAITLANRAGRSASS--------LLMPLAFASLLGGMTTLIGTPPNLIISNLRRDLLGEPYGMFS 176
Cdd:TIGR00785 132 IIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGD 196
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 302-364 4.34e-05

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.83  E-value: 4.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1902505929 302 LASDDVRLAEVVVTALSPIVGQSAVSLNLRQRFNINLIAVSRQGQRLRERLvNARFKAGDVLL 364
Cdd:COG0569   235 LADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVIIPSG-DTVLEAGDELI 296
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 404-583 5.77e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 45.71  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 404 GGIFLVAIVAATLNLLPVA----VSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTGGAKLIAEGVL 479
Cdd:cd01116   221 LTILTLVIIGFVLHSPLGVslgwIALLGALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLV 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 480 GVAADWPvMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAAS-SAFLTPIGHQSNTLVMG 558
Cdd:cd01116   301 GVILGRI-AVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGAClGGNGTLIGASANVVAAG 379

                         170       180       190
                  ....*....|....*....|....*....|
gi 1902505929 559 PG---GYKFS--DYWKVGLPLEIIVVAVGA 583
Cdd:cd01116   380 IAeqhGYKISfwEFLKVGFPIMLVSLILAT 409
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 57-160 3.56e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 43.51  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  57 VITVAAVLVISQALQKTGLVNVL---VRGLSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVAITLANRA-GRSA 132
Cdd:pfam00939 325 LIWLGGLIMLANGLERSGFIEWLgntLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPP 404

                          90       100
                  ....*....|....*....|....*...
gi 1902505929 133 SSLLMPLAFASLLGGMTTLIGTPPNLII 160
Cdd:pfam00939 405 LLAALLLGFAISLGGFLTPYGTGPGPIY 432
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 449-590 4.87e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 42.74  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 449 WPILVLLATLIPVGAALSSTGGAKLIAEGVLG-VAADWPVMAVLVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLD- 526
Cdd:pfam00939 322 WNTLIWLGGLIMLANGLERSGFIEWLGNTLSTsLSGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPg 401

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1902505929 527 ANPDAFLMAVTLAASSA-FLTPIGHQSNTLVMGPGGYKFSDYWKVGLPLEIIVVAVGAPVIALVW 590
Cdd:pfam00939 402 APPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWW 466
PLN00136 PLN00136
silicon transporter; Provisional
 42-161 7.31e-04

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 42.29  E-value: 7.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929  42 VVKGNEAFRGFSEPAVITVAAVLVISQALQKTGLVNVLVRGLSRVGNGMTAQILVMCVVVAVLSSFMNNVGALAIMLPVA 121
Cdd:PLN00136   51 VISPDDAYASIDLPILGLLFATMVVGSYLKNAGMFKHLGRLLAWRSQGGRDLLCRVCVVTALASALFTNDTCCVVLTEFV 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1902505929 122 ITLANRAGRSASSLLMPLAFASLLGGMTTLIGTPPNLIIS 161
Cdd:PLN00136  131 LELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIA 170
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 416-590 1.48e-03

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 41.11  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 416 LNLLPVAVSFTAAATLMLLLRLINLRDVYESIEWPILVLLATLIPVGAALSSTggakliaeGVLGVAADWPVMAV----- 490
Cdd:cd01117     8 GLRLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELS--------GFFDALGSRILVKAgsprr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1902505929 491 -LVVVMVLTMTLSDVINNAAAALITAPIAVTIAQGLDANPDAFLMAVTLAAS--SAfLTPIGHQSNTLVMGPGGYKFSDY 567
Cdd:cd01117    80 lLFLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANigSA-ATPIGNPQNLLIASESGISFPFF 158

                         170       180
                  ....*....|....*....|...
gi 1902505929 568 WKVGLPLEIIvvAVGAPVIALVW 590
Cdd:cd01117   159 LAAMAPLALL--GLLLLLILLLV 179
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 202-272 5.80e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 38.89  E-value: 5.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1902505929 202 QRVSGENRADLYRMAD---YMTEVRLPAGSALAGQRVMDLG--KVEGVQVVSLVRGEsQRPFPTPFTVLQPEDVLI 272
Cdd:COG0569   222 RLLLRPGVLDVLELADgdaEIVEVTVPEGSPLVGKTLKELDlrERYGVTVVAIKRGG-EVIIPSGDTVLEAGDELI 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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