autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins; The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.

                          10        20
                  ....*....|....*....|....
gi 2034252164 871 CPVCNANFEPSVPQAEFERHVHSH 894
Cdd:cd21965     1 CPICNKQFPPQVDQEAFEDHVESH 24

autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins; The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.

                          10        20
                  ....*....|....*....|....
gi 2034252164 871 CPVCNANFEPSVPQAEFERHVHSH 894
Cdd:cd21965     1 CPICNKQFPPQVDQEAFEDHVESH 24

Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and coiled-coil domain 2/NDP25 (CALCOCO2/NDP25) found in Homo sapiens. CALCOCO2/NDP25 is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.

                          10        20
                  ....*....|....*....|....*..
gi 2034252164 869 RSCPVCNANFEPSVPQAEFERHVHSHF 895
Cdd:pfam18112   1 KECPLCGEMFSPNIDQSEFEEHVESHF 27

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 109 TVKNLQGELeeskRNEAHLHKMLKQQIAMNLRDQHqvngssftvDGLPAAPASDGVVESVKDGHIRRLgRELTLLRANLH 188
Cdd:pfam10174  75 TIQALQDEL----RAQRDLNQLLQQDFTTSPVDGE---------DKFSTPELTEENFRRLQSEHERQA-KELFLLRKTLE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 189 DWEVRFAAVAK---ERDSALQKVV-----------------SLSALLAESQQCVED----LQQKNSELSTLATmSLQRQE 244
Cdd:pfam10174 141 EMELRIETQKQtlgARDESIKKLLemlqskglpkksgeedwERTRRIAEAEMQLGHlevlLDQKEKENIHLRE-ELHRRN 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 245 AAiHGSSEKEDTLKEEVDRQRAEISTLKESVQRLSRENKSLKDDaAVLNSRQPNsfgmsSGSNSVACCSQELEYLHNVVD 324
Cdd:pfam10174 220 QL-QPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTN-GLLHTEDRE-----EEIKQMEVYKSHSKFMKNKID 292

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2034252164 325 TLKATVVEQQKKLLSLRCPQKKINQAGSAVSQSVEV 360
Cdd:pfam10174 293 QLKQELSKKESELLALQTKLETLTNQNSDCKQHIEV 328

autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins; The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.

                          10        20
                  ....*....|....*....|....
gi 2034252164 871 CPVCNANFEPSVPQAEFERHVHSH 894
Cdd:cd21965     1 CPICNKQFPPQVDQEAFEDHVESH 24

first C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins; TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. It inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 contains two C2H2-type zinc binding domains; this model corresponds to the first one.

                          10        20
                  ....*....|....*....|....
gi 2034252164 871 CPVCNANFEPSVPQAEFERHVHSH 894
Cdd:cd21969     1 CPLCELVFPPNYDQSKFEQHVESH 24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164  169 KDGHIRRLGRELTLLRANLHDWEVRFAAVAKERDSALQKVVSLSALLAESQQCVEDLQQKNSELSTLATMSLQR---QEA 245
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRleeLEE 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164  246 AIHGSSEKEDTLKEEVDRQRAEISTLKESVQRLSRENKSLKDDAAVLNSRQPNsfgmssgsNSVACCSQELEYLHNVVDT 325
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--------AELKELQAELEELEEELEE 451

                          170       180
                   ....*....|....*....|....*
gi 2034252164  326 LKATVVEQQKKLLSLRCPQKKINQA 350
Cdd:TIGR02168  452 LQEELERLEEALEELREELEEAEQA 476

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 109 TVKNLQGELeeskRNEAHLHKMLKQQIAMNLRDQHqvngssftvDGLPAAPASDGVVESVKDGHIRRLgRELTLLRANLH 188
Cdd:pfam10174  75 TIQALQDEL----RAQRDLNQLLQQDFTTSPVDGE---------DKFSTPELTEENFRRLQSEHERQA-KELFLLRKTLE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 189 DWEVRFAAVAK---ERDSALQKVV-----------------SLSALLAESQQCVED----LQQKNSELSTLATmSLQRQE 244
Cdd:pfam10174 141 EMELRIETQKQtlgARDESIKKLLemlqskglpkksgeedwERTRRIAEAEMQLGHlevlLDQKEKENIHLRE-ELHRRN 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 245 AAiHGSSEKEDTLKEEVDRQRAEISTLKESVQRLSRENKSLKDDaAVLNSRQPNsfgmsSGSNSVACCSQELEYLHNVVD 324
Cdd:pfam10174 220 QL-QPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTN-GLLHTEDRE-----EEIKQMEVYKSHSKFMKNKID 292

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2034252164 325 TLKATVVEQQKKLLSLRCPQKKINQAGSAVSQSVEV 360
Cdd:pfam10174 293 QLKQELSKKESELLALQTKLETLTNQNSDCKQHIEV 328

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2034252164 238 MSLQ---RQEAAIHGSSEKEDTLKEEVDRQRAEISTLKESVQRLSRENKSLKDDAAVLNSR 295
Cdd:pfam06005   1 MSLElleQLETKIQAAVDTIALLQMENEELKEENEELKEEANELEEENQQLKQERNQWQER 61

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 173 IRRLGRELTLLRANLHDWEVRFAAVAKERDSALQKVVSLSALLAESQQCVEDLQQKnselstlatmsLQRQEAAIHGSSE 252
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE-----------LAALEAELAELEK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034252164 253 KEDTLKEEVDRQRAEISTLKESVQRLSRENKslkdDAAVLNSRQPNSFGMSsgsnsvaccsqeLEYLHNVVDTLKATVVE 332
Cdd:COG4942    91 EIAELRAELEAQKEELAELLRALYRLGRQPP----LALLLSPEDFLDAVRR------------LQYLKYLAPARREQAEE 154

                         170
                  ....*....|....*...
gi 2034252164 333 QQKKLLSLRCPQKKINQA 350
Cdd:COG4942   155 LRADLAELAALRAELEAE 172

C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) and similar proteins; CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. It acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. It may play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion. CALCOCO2 contains a C2H2-type zinc binding domain.

                          10        20
                  ....*....|....*....|....*..
gi 2034252164 869 RSCPVCNANFEPSvPQAEFERHVHSHF 895
Cdd:cd21968     1 FECPICSKIFEAT-SKQEFEDHVFCHS 26