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Conserved domains on  [gi|1391980642|dbj|GBK56660|]
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vancomycin high temperature exclusion protein [Edwardsiella piscicida]

Protein Classification

vancomycin high temperature exclusion protein( domain architecture ID 10793485)

vancomycin high temperature exclusion protein similar to Escherichia coli SanA, which participates in the barrier function of the cell envelope

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10834 PRK10834
outer membrane permeability protein SanA;
2-240 3.07e-170

outer membrane permeability protein SanA;


:

Pssm-ID: 182765  Cd Length: 239  Bit Score: 468.42  E-value: 3.07e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   2 WWKRLIYGLIGVGILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAKYVAPGVINQYYRYRIQGALNAYNSN 81
Cdd:PRK10834    1 MLKRLIYSLLVLIGLLLLTVLGLDRWMSWKTAPYIYDELQDLPYRQVGVVLGTAKYYRTGVINQYYRYRIQGAINAYNSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  82 KVSYLLLSGDNALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFTIITQRFHCERALFIAMHL 161
Cdd:PRK10834   81 KVNYLLLSGDNALQSYNEPMTMRKDLIAAGVDPSDIVLDYAGFRTLDSIVRTRKVFDTNDFIIITQRFHCERALFIALHM 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391980642 162 GIQAQCLAVPSPKDMLLVRLREIGARLGALTDLYLLQRQPRFLGPPIPIPAVHKVAADAQSYPAVLPEQLQALEQQPHH 240
Cdd:PRK10834  161 GIQAQCYAVPSPKNMLSVRLREFGARLGALADLYILKREPRFLGPLVPIPAMHQVPEDAQGYPAVTPEQLLELQKKQGK 239
 
Name Accession Description Interval E-value
PRK10834 PRK10834
outer membrane permeability protein SanA;
2-240 3.07e-170

outer membrane permeability protein SanA;


Pssm-ID: 182765  Cd Length: 239  Bit Score: 468.42  E-value: 3.07e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   2 WWKRLIYGLIGVGILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAKYVAPGVINQYYRYRIQGALNAYNSN 81
Cdd:PRK10834    1 MLKRLIYSLLVLIGLLLLTVLGLDRWMSWKTAPYIYDELQDLPYRQVGVVLGTAKYYRTGVINQYYRYRIQGAINAYNSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  82 KVSYLLLSGDNALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFTIITQRFHCERALFIAMHL 161
Cdd:PRK10834   81 KVNYLLLSGDNALQSYNEPMTMRKDLIAAGVDPSDIVLDYAGFRTLDSIVRTRKVFDTNDFIIITQRFHCERALFIALHM 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391980642 162 GIQAQCLAVPSPKDMLLVRLREIGARLGALTDLYLLQRQPRFLGPPIPIPAVHKVAADAQSYPAVLPEQLQALEQQPHH 240
Cdd:PRK10834  161 GIQAQCYAVPSPKNMLSVRLREFGARLGALADLYILKREPRFLGPLVPIPAMHQVPEDAQGYPAVTPEQLLELQKKQGK 239
SanA COG2949
Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin [Cell ...
2-211 1.21e-114

Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442192  Cd Length: 214  Bit Score: 327.12  E-value: 1.21e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   2 WWKRLIYGLIGVGILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAKYVApGVINQYYRYRIQGALNAYNSN 81
Cdd:COG2949     4 RLRRLLKILLALLLLALLLLLAINVWVSLSTAGRIYTDVEELPARPVALVLGASVYPD-GTPNPYLADRLDAAAELYKAG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  82 KVSYLLLSGDNALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFTIITQRFHCERALFIAMHL 161
Cdd:COG2949    83 KVKYLLVSGDNSTKSYNEPRAMRRYLIKRGVPAEDIVLDYAGFRTYDSCVRARKVFGVDRATIVTQRFHLPRALFIARAL 162
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1391980642 162 GIQAQCLAVPSPKDM--LLVRLREIGARLGALTDLYLLQRQPRFLGPPIPIP 211
Cdd:COG2949   163 GIDAIGVAADDVSYRsgLKVRLREVLARVKAFLDLYLLRREPRFLGPPEPIV 214
YdcF-like cd06259
YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found ...
47-189 1.02e-26

YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.


Pssm-ID: 99750  Cd Length: 150  Bit Score: 100.85  E-value: 1.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  47 EVGVVLGTAKYvaPGVINQYYRYRIQGALNAYNSNKVSYLLLSGDN-ALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFR 125
Cdd:cd06259     1 DAIVVLGGGVN--GDGPSPILAERLDAAAELYRAGPAPKLIVSGGQgPGEGYSEAEAMARYLIELGVPAEAILLEDRSTN 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391980642 126 TLDSIVRARRVFDTDDFT---IITQRFHCERALFIAMHLGIQAQCLAVPSPKDMLLVRLREIGARLG 189
Cdd:cd06259    79 TYENARFSAELLRERGIRsvlLVTSAYHMPRALLIFRKAGLDVEVVPAPTDFYSLSSALRLLRLALR 145
DUF218 pfam02698
DUF218 domain; This large family of proteins contains several highly conserved charged amino ...
50-165 4.84e-17

DUF218 domain; This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes SanA, which is involved in Vancomycin resistance. This protein may be involved in murein synthesis.


Pssm-ID: 460654  Cd Length: 138  Bit Score: 74.99  E-value: 4.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  50 VVLGTAkyvapgvINQYYRYRIQGALNAYNSNKvsYLLLSGDNALQ-SYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLD 128
Cdd:pfam02698   4 VVLGAA-------LSPVLAARLDAAAELYREGP--PIIVSGGQGGGePYSEAEAMARYLLELGVPEERIILEDRSRNTYE 74
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1391980642 129 SIVRARRVFDT--DDFTIITQRFHCERALFIAMHLGIQA 165
Cdd:pfam02698  75 NARFSAELLKEriRRILLVTSAFHMPRALLLFRRAGLDV 113
 
Name Accession Description Interval E-value
PRK10834 PRK10834
outer membrane permeability protein SanA;
2-240 3.07e-170

outer membrane permeability protein SanA;


Pssm-ID: 182765  Cd Length: 239  Bit Score: 468.42  E-value: 3.07e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   2 WWKRLIYGLIGVGILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAKYVAPGVINQYYRYRIQGALNAYNSN 81
Cdd:PRK10834    1 MLKRLIYSLLVLIGLLLLTVLGLDRWMSWKTAPYIYDELQDLPYRQVGVVLGTAKYYRTGVINQYYRYRIQGAINAYNSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  82 KVSYLLLSGDNALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFTIITQRFHCERALFIAMHL 161
Cdd:PRK10834   81 KVNYLLLSGDNALQSYNEPMTMRKDLIAAGVDPSDIVLDYAGFRTLDSIVRTRKVFDTNDFIIITQRFHCERALFIALHM 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391980642 162 GIQAQCLAVPSPKDMLLVRLREIGARLGALTDLYLLQRQPRFLGPPIPIPAVHKVAADAQSYPAVLPEQLQALEQQPHH 240
Cdd:PRK10834  161 GIQAQCYAVPSPKNMLSVRLREFGARLGALADLYILKREPRFLGPLVPIPAMHQVPEDAQGYPAVTPEQLLELQKKQGK 239
SanA COG2949
Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin [Cell ...
2-211 1.21e-114

Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442192  Cd Length: 214  Bit Score: 327.12  E-value: 1.21e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   2 WWKRLIYGLIGVGILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAKYVApGVINQYYRYRIQGALNAYNSN 81
Cdd:COG2949     4 RLRRLLKILLALLLLALLLLLAINVWVSLSTAGRIYTDVEELPARPVALVLGASVYPD-GTPNPYLADRLDAAAELYKAG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  82 KVSYLLLSGDNALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFTIITQRFHCERALFIAMHL 161
Cdd:COG2949    83 KVKYLLVSGDNSTKSYNEPRAMRRYLIKRGVPAEDIVLDYAGFRTYDSCVRARKVFGVDRATIVTQRFHLPRALFIARAL 162
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1391980642 162 GIQAQCLAVPSPKDM--LLVRLREIGARLGALTDLYLLQRQPRFLGPPIPIP 211
Cdd:COG2949   163 GIDAIGVAADDVSYRsgLKVRLREVLARVKAFLDLYLLRREPRFLGPPEPIV 214
YdcF-like cd06259
YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found ...
47-189 1.02e-26

YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.


Pssm-ID: 99750  Cd Length: 150  Bit Score: 100.85  E-value: 1.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  47 EVGVVLGTAKYvaPGVINQYYRYRIQGALNAYNSNKVSYLLLSGDN-ALQSYNEPVTMRRDLIAAGVPNGDIVLDYAGFR 125
Cdd:cd06259     1 DAIVVLGGGVN--GDGPSPILAERLDAAAELYRAGPAPKLIVSGGQgPGEGYSEAEAMARYLIELGVPAEAILLEDRSTN 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391980642 126 TLDSIVRARRVFDTDDFT---IITQRFHCERALFIAMHLGIQAQCLAVPSPKDMLLVRLREIGARLG 189
Cdd:cd06259    79 TYENARFSAELLRERGIRsvlLVTSAYHMPRALLIFRKAGLDVEVVPAPTDFYSLSSALRLLRLALR 145
DUF218 pfam02698
DUF218 domain; This large family of proteins contains several highly conserved charged amino ...
50-165 4.84e-17

DUF218 domain; This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes SanA, which is involved in Vancomycin resistance. This protein may be involved in murein synthesis.


Pssm-ID: 460654  Cd Length: 138  Bit Score: 74.99  E-value: 4.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  50 VVLGTAkyvapgvINQYYRYRIQGALNAYNSNKvsYLLLSGDNALQ-SYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLD 128
Cdd:pfam02698   4 VVLGAA-------LSPVLAARLDAAAELYREGP--PIIVSGGQGGGePYSEAEAMARYLLELGVPEERIILEDRSRNTYE 74
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1391980642 129 SIVRARRVFDT--DDFTIITQRFHCERALFIAMHLGIQA 165
Cdd:pfam02698  75 NARFSAELLKEriRRILLVTSAFHMPRALLLFRRAGLDV 113
ElyC COG1434
Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family [Cell wall/membrane ...
3-171 6.40e-15

Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441043  Cd Length: 212  Bit Score: 71.21  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642   3 WKRLIYGLIGVG-----ILSGLAALALDRWISWVTAPYIYEDVQDLPRREVGVVLGTAkyVAPGVINQYYRYRIQGALNA 77
Cdd:COG1434     2 LSKLLLLLLLLGrrrllLLLALLLLLLLSPVGFWLLRPLERYADPPQPADAIVVLGGG--VYDGRPSPVLLERLDAAARL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391980642  78 YNSNKVSYLLLSGDNAL-QSYNEPVTMRRDLIAAGVPNGDIVLDYAGFRTLDSIVRARRVFDTDDFT---IITQRFHCER 153
Cdd:COG1434    80 YRQGPAPRIIVSGGQGPgEGVSEAEVMARYLLALGVPAERILLEDRSRNTWENARFSAALLRERGIRrviLVTSAYHMPR 159
                         170
                  ....*....|....*...
gi 1391980642 154 ALFIAMHLGIQAQCLAVP 171
Cdd:COG1434   160 ALALFRRAGLEVIPAPTD 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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