Pumilio-like 1 [Hondaea fermentalgiana]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Pumilio | cd07920 | Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology ... |
447-825 | 1.19e-110 | ||||||
Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology domain) mediate sequence specific RNA binding in fly Pumilio, worm FBF-1 and FBF-2, and many other proteins such as vertebrate Pumilio. These proteins function as translational repressors in early embryonic development by binding to sequences in the 3' UTR of target mRNAs, such as the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA. Other proteins that contain Puf domains are also plausible RNA binding proteins. Yeast PUF1 (JSN1), for instance, appears to contain a single RNA-recognition motif (RRM) domain. Puf repeat proteins have been observed to function asymmetrically and may be responsible for creating protein gradients involved in the specification of cell fate and differentiation. Puf domains usually occur as a tandem repeat of 8 domains. This model encompasses all 8 tandem repeats. Some proteins may have fewer (canonical) repeats. : Pssm-ID: 153420 [Multi-domain] Cd Length: 322 Bit Score: 355.36 E-value: 1.19e-110
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| SUF4-like | cd20908 | N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ... |
1665-1741 | 2.12e-42 | ||||||
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725. : Pssm-ID: 411020 [Multi-domain] Cd Length: 82 Bit Score: 150.01 E-value: 2.12e-42
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| Herpes_BLLF1 super family | cl37540 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1874-2092 | 1.09e-04 | ||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. The actual alignment was detected with superfamily member pfam05109: Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 47.60 E-value: 1.09e-04
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| SEC14 super family | cl49604 | Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ... |
1182-1317 | 5.64e-03 | ||||||
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. The actual alignment was detected with superfamily member cd00170: Pssm-ID: 469559 [Multi-domain] Cd Length: 156 Bit Score: 39.62 E-value: 5.64e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| Pumilio | cd07920 | Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology ... |
447-825 | 1.19e-110 | ||||||
Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology domain) mediate sequence specific RNA binding in fly Pumilio, worm FBF-1 and FBF-2, and many other proteins such as vertebrate Pumilio. These proteins function as translational repressors in early embryonic development by binding to sequences in the 3' UTR of target mRNAs, such as the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA. Other proteins that contain Puf domains are also plausible RNA binding proteins. Yeast PUF1 (JSN1), for instance, appears to contain a single RNA-recognition motif (RRM) domain. Puf repeat proteins have been observed to function asymmetrically and may be responsible for creating protein gradients involved in the specification of cell fate and differentiation. Puf domains usually occur as a tandem repeat of 8 domains. This model encompasses all 8 tandem repeats. Some proteins may have fewer (canonical) repeats. Pssm-ID: 153420 [Multi-domain] Cd Length: 322 Bit Score: 355.36 E-value: 1.19e-110
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| COG5099 | COG5099 | RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
459-835 | 3.21e-64 | ||||||
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 235.41 E-value: 3.21e-64
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| SUF4-like | cd20908 | N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ... |
1665-1741 | 2.12e-42 | ||||||
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725. Pssm-ID: 411020 [Multi-domain] Cd Length: 82 Bit Score: 150.01 E-value: 2.12e-42
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
773-802 | 2.32e-07 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 48.58 E-value: 2.32e-07
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
453-489 | 8.02e-07 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 47.30 E-value: 8.02e-07
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| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1874-2092 | 1.09e-04 | ||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 47.60 E-value: 1.09e-04
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| zf-C2H2_jaz | pfam12171 | Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ... |
1665-1686 | 5.63e-03 | ||||||
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization. Pssm-ID: 432381 [Multi-domain] Cd Length: 27 Bit Score: 35.99 E-value: 5.63e-03
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| SEC14 | cd00170 | Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ... |
1182-1317 | 5.64e-03 | ||||||
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. Pssm-ID: 469559 [Multi-domain] Cd Length: 156 Bit Score: 39.62 E-value: 5.64e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| Pumilio | cd07920 | Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology ... |
447-825 | 1.19e-110 | ||||||
Pumilio-family RNA binding domain; Puf repeats (also labelled PUM-HD or Pumilio homology domain) mediate sequence specific RNA binding in fly Pumilio, worm FBF-1 and FBF-2, and many other proteins such as vertebrate Pumilio. These proteins function as translational repressors in early embryonic development by binding to sequences in the 3' UTR of target mRNAs, such as the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA. Other proteins that contain Puf domains are also plausible RNA binding proteins. Yeast PUF1 (JSN1), for instance, appears to contain a single RNA-recognition motif (RRM) domain. Puf repeat proteins have been observed to function asymmetrically and may be responsible for creating protein gradients involved in the specification of cell fate and differentiation. Puf domains usually occur as a tandem repeat of 8 domains. This model encompasses all 8 tandem repeats. Some proteins may have fewer (canonical) repeats. Pssm-ID: 153420 [Multi-domain] Cd Length: 322 Bit Score: 355.36 E-value: 1.19e-110
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| COG5099 | COG5099 | RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
459-835 | 3.21e-64 | ||||||
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 235.41 E-value: 3.21e-64
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| SUF4-like | cd20908 | N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ... |
1665-1741 | 2.12e-42 | ||||||
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725. Pssm-ID: 411020 [Multi-domain] Cd Length: 82 Bit Score: 150.01 E-value: 2.12e-42
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
773-802 | 2.32e-07 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 48.58 E-value: 2.32e-07
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
453-489 | 8.02e-07 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 47.30 E-value: 8.02e-07
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
776-805 | 1.94e-06 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 46.14 E-value: 1.94e-06
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
705-739 | 3.81e-06 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 45.37 E-value: 3.81e-06
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
625-659 | 2.84e-05 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 42.67 E-value: 2.84e-05
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| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1874-2092 | 1.09e-04 | ||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 47.60 E-value: 1.09e-04
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
701-735 | 6.32e-04 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 38.95 E-value: 6.32e-04
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
487-524 | 2.93e-03 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 37.03 E-value: 2.93e-03
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
584-620 | 3.27e-03 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 37.03 E-value: 3.27e-03
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| Pumilio | smart00025 | Pumilio-like repeats; Pumilio-like repeats that bind RNA. |
449-485 | 4.02e-03 | ||||||
Pumilio-like repeats; Pumilio-like repeats that bind RNA. Pssm-ID: 214475 [Multi-domain] Cd Length: 36 Bit Score: 36.64 E-value: 4.02e-03
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| zf-C2H2_jaz | pfam12171 | Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ... |
1665-1686 | 5.63e-03 | ||||||
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization. Pssm-ID: 432381 [Multi-domain] Cd Length: 27 Bit Score: 35.99 E-value: 5.63e-03
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| SEC14 | cd00170 | Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ... |
1182-1317 | 5.64e-03 | ||||||
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits. Pssm-ID: 469559 [Multi-domain] Cd Length: 156 Bit Score: 39.62 E-value: 5.64e-03
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| PUF | pfam00806 | Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are ... |
495-525 | 8.18e-03 | ||||||
Pumilio-family RNA binding repeat; Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognize all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure. Pssm-ID: 459944 [Multi-domain] Cd Length: 35 Bit Score: 35.74 E-value: 8.18e-03
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| Blast search parameters | ||||
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