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Conserved domains on  [gi|1767231856|sp|F8VPZ5|]
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RecName: Full=DNA excision repair protein ERCC-6; AltName: Full=ATP-dependent helicase ERCC6; AltName: Full=Cockayne syndrome protein CSB

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 280-983 5.97e-142

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 451.22  E-value: 5.97e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  280 AQLSFERKKQAATKRTAKKAIVISESSRAAIETKADQRSQVLSQTDKRLKKHSRKLQRRALQFQGKVGLPSGKKPLEPEV 359
Cdd:COG0553     16 LLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  360 RPEAEGDTEGEESGSSPTDGEEEEEQEEEEGVASLSSDDVSYELKPLRKR-QKYQKKVPVQEIDDDFFPSSEEEDEAMEG 438
Cdd:COG0553     96 LLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALlLLLLLLLLLALLLGRLLLLALLLLALEAL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  439 RGGGRKVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEESDAE--FDEGFKVPGFLFKKLFKYQQTGVRWLWE 516
Cdd:COG0553    176 LLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRrlREALESLPAGLKATLRPYQLEGAAWLLF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  517 LHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskiRTRGSNyrfeglGPTIIVCPTTVMHQWVKEFHTWWPPFRVAVLHET 596
Cdd:COG0553    256 LRRLGLGGLLADDMGLGKTIQALALLLEL-----KERGLA------RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  597 GSyTHKKERLIRDivycHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQN 676
Cdd:COG0553    325 RE-RAKGANPFED----ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVEN 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  677 NLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASpvqvktaykcacVLRDTINPYLLRRMKSDVKmsLSLPDKN 756
Cdd:COG0553    400 RLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALE------------RLRRLLRPFLLRRTKEDVL--KDLPEKT 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  757 EQVLFCRLTDEQHKVYQNFIDskAVYRILNGEN------QIFSGLVALRKICNHPDLFSGgpknasgppedelEEEQFGH 830
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLE--YLRRELEGAEgirrrgLILAALTRLRQICSHPALLLE-------------EGAELSG 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  831 WrrSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTT 910
Cdd:COG0553    531 R--SAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767231856  911 RVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVL 983
Cdd:COG0553    609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
CSB_WHD cd22254
winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, ...
 1410-1480 2.62e-31

winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, also called cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, ERCC Excision Repair 6, or ATP-dependent helicase ERCC6, is involved in many DNA repair processes and is essential for transcription-coupled repair (TCR). It regulates DNA double-strand break (DSB) repair and checkpoint activation. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for TCR complex formation. CSB also regulates transcription and chromatin remodeling activities that are essential for neuronal differentiation and neuritogenesis. This model corresponds to the winged-helix domain (WHD) of CSB, which is involved in the recruitment of CSB to DSBs. The CSB WHD folds as a single globular domain, defining a class of ubiquitin-binding domains (UBDs) different from other UBD classes.


:

Pssm-ID: 439329  Cd Length: 72  Bit Score: 117.61  E-value: 2.62e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767231856 1410 TEHDDLLVDMRNFIAFQAqvDGQASTQEILQEFESKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEY 1480
Cdd:cd22254      3 TEAEELLADIRDFLAFQA--GGQATTDEIVDHFKDRLPPEQSALFKALLKQICTFERDPGGRGVWVLKPEF 71
cc_ERCC-6_N cd21397
coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 ...
 83-159 2.48e-30

coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 (ERCC-6) and related proteins; This model represents a coiled-coil domain located near the N-terminus of ERCC-6 and related proteins. ERCC-6 (also known as Cockayne syndrome group B, CSB) is a DNA-binding protein important in eukaryotic transcription-coupled repair (TCR). TCR is a well-conserved sub-pathway of nucleotide excision repair (NER) that preferentially removes DNA lesions from the template strand blocking translocation of RNA polymerase II (Pol II). In a model for TCR, the processing Pol II encounters the lesion on the transcribed DNA strand and stalls; it is then displaced by the TCR-initiation complex which includes ERCC-6, ERCC-8, UVSSA and USP7; TCR-specific factors then access the lesion for the DNA damage incision process. The N-terminal region, the ATPase domain and the C-terminal region of ERCC-6 all directly contribute to DNA association and catalytic activity. The ATPase domain functions in concert with either the N- or C-terminal region to mediate UV-induced chromatin association. The N-terminal region prevents ERCC-6 from stably associating with chromatin under normal growth conditions, and the C-terminal region of ERCC-6 promotes stable chromatin association in the presence of lesion-stalled transcription. In addition to this coiled-coil domain, the N-terminal region of ERCC-6 includes two lysine residues subject to SUMOylation, a nucleolar localization signal NoLS1, and a nuclear localization signal NLS1. ERCC-6 also includes a SWI/SNF-like ATPase domain, a nucleotide-binding domain and a ubiquitin-binding domain. This coiled-coil domain binds magnesium. This domain family does not include Saccharomyces cerevisiae RAD26, and Schizosaccharomyces pombe Rhp26.


:

Pssm-ID: 411064 [Multi-domain]  Cd Length: 77  Bit Score: 115.00  E-value: 2.48e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231856   83 VEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSP 159
Cdd:cd21397      1 VPESDQASELQGLGVDVYDQDEFEQGVLQQVDQAIAEEEEERRKKDAEKELKSVLDDIRSVKQDLEHIEKVLEQLEP 77
46 super family cl33686
endonuclease subunit; Provisional
 122-199 3.17e-03

endonuclease subunit; Provisional


The actual alignment was detected with superfamily member PHA02562:

Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 3.17e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  122 CVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAIL 199
Cdd:PHA02562   290 CTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAI 367
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 280-983 5.97e-142

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 451.22  E-value: 5.97e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  280 AQLSFERKKQAATKRTAKKAIVISESSRAAIETKADQRSQVLSQTDKRLKKHSRKLQRRALQFQGKVGLPSGKKPLEPEV 359
Cdd:COG0553     16 LLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  360 RPEAEGDTEGEESGSSPTDGEEEEEQEEEEGVASLSSDDVSYELKPLRKR-QKYQKKVPVQEIDDDFFPSSEEEDEAMEG 438
Cdd:COG0553     96 LLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALlLLLLLLLLLALLLGRLLLLALLLLALEAL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  439 RGGGRKVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEESDAE--FDEGFKVPGFLFKKLFKYQQTGVRWLWE 516
Cdd:COG0553    176 LLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRrlREALESLPAGLKATLRPYQLEGAAWLLF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  517 LHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskiRTRGSNyrfeglGPTIIVCPTTVMHQWVKEFHTWWPPFRVAVLHET 596
Cdd:COG0553    256 LRRLGLGGLLADDMGLGKTIQALALLLEL-----KERGLA------RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  597 GSyTHKKERLIRDivycHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQN 676
Cdd:COG0553    325 RE-RAKGANPFED----ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVEN 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  677 NLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASpvqvktaykcacVLRDTINPYLLRRMKSDVKmsLSLPDKN 756
Cdd:COG0553    400 RLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALE------------RLRRLLRPFLLRRTKEDVL--KDLPEKT 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  757 EQVLFCRLTDEQHKVYQNFIDskAVYRILNGEN------QIFSGLVALRKICNHPDLFSGgpknasgppedelEEEQFGH 830
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLE--YLRRELEGAEgirrrgLILAALTRLRQICSHPALLLE-------------EGAELSG 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  831 WrrSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTT 910
Cdd:COG0553    531 R--SAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767231856  911 RVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVL 983
Cdd:COG0553    609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 503-690 2.54e-119

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 371.27  E-value: 2.54e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyrfEGLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18000      1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSK----------LGLGPSLIVCPATVLKQWVKEFH 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLHETGSYTHKKE---------RLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:cd18000     71 RWWPPFRVVVLHSSGSGTGSEEklgsierksQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAE 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFP 690
Cdd:cd18000    151 ITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 506-808 1.92e-115

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 364.70  E-value: 1.92e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQ-QAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFHTW 584
Cdd:pfam00176    1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGG---------PTLIVVPLSLLHNWMNEFERW 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  585 W--PPFRVAVLHETGSYTHKkERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFR 662
Cdd:pfam00176   72 VspPALRVVVLHGNKRPQER-WKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  663 TPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGysnaspvqvktAYKCACVLRDTINPYLLRRM 742
Cdd:pfam00176  151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGG-----------GKKGVSRLHKLLKPFLLRRT 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231856  743 KSDVkmSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGEN------QIFSGLVALRKICNHPDLF 808
Cdd:pfam00176  220 KKDV--EKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGgreikaSLLNILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 354-971 6.76e-90

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 316.36  E-value: 6.76e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  354 PLEPEVRPEAE-GDTEGEESGSSPTDGEEEEeqeeeeGVASLSSDDVSYELKPLRKRQKYQKKVPVQEIDDDffpSSEEE 432
Cdd:PLN03142    17 ELEAVARSAGSdSDDDEVPAEDEDEDEEDDE------EAESPAKAEISKREKARLKELKKQKKQEIQKILEQ---QNAAI 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  433 DEAMEGRGGGR-KVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEesDAEF----DEGFKV---------PGF 498
Cdd:PLN03142    88 DADMNNKGKGRlKYLLQQTEIFAHFAKGDQSASAKKAKGRGRHASKLTEEEE--DEEYlkeeEDGLGGsggtrllvqPSC 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  499 LFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskirtrgsnYRFEGL-GPTIIVCPTTVMHQW 577
Cdd:PLN03142   166 IKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYL-----------HEYRGItGPHMVVAPKSTLGNW 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  578 VKEFHTWWPPFRVAVLHETgsythKKERLIRDIVYCHG----VLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:PLN03142   235 MNEIRRFCPVLRAVKFHGN-----PEERAHQREELLVAgkfdVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSL 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitMGGYSNASPVqVKTAYKcacVLRdt 733
Cdd:PLN03142   310 LSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ----ISGENDQQEV-VQQLHK---VLR-- 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  734 inPYLLRRMKSDVKMSLslPDKNEQVLFCRLTDEQHKVYQNFI--DSKAV------YRILNGENQifsglvaLRKICNHP 805
Cdd:PLN03142   380 --PFLLRRLKSDVEKGL--PPKKETILKVGMSQMQKQYYKALLqkDLDVVnaggerKRLLNIAMQ-------LRKCCNHP 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  806 DLFSGGpknASGPP---EDELEEEqfghwrrSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMD 882
Cdd:PLN03142   449 YLFQGA---EPGPPyttGEHLVEN-------SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRID 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  883 GTTTIASRQPLITKYN-EDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTA 961
Cdd:PLN03142   519 GNTGGEDRDASIDAFNkPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTE 598

                          650
                   ....*....|
gi 1767231856  962 GTIEEKIYHR 971
Cdd:PLN03142   599 YTIEEKVIER 608
CSB_WHD cd22254
winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, ...
 1410-1480 2.62e-31

winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, also called cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, ERCC Excision Repair 6, or ATP-dependent helicase ERCC6, is involved in many DNA repair processes and is essential for transcription-coupled repair (TCR). It regulates DNA double-strand break (DSB) repair and checkpoint activation. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for TCR complex formation. CSB also regulates transcription and chromatin remodeling activities that are essential for neuronal differentiation and neuritogenesis. This model corresponds to the winged-helix domain (WHD) of CSB, which is involved in the recruitment of CSB to DSBs. The CSB WHD folds as a single globular domain, defining a class of ubiquitin-binding domains (UBDs) different from other UBD classes.


Pssm-ID: 439329  Cd Length: 72  Bit Score: 117.61  E-value: 2.62e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767231856 1410 TEHDDLLVDMRNFIAFQAqvDGQASTQEILQEFESKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEY 1480
Cdd:cd22254      3 TEAEELLADIRDFLAFQA--GGQATTDEIVDHFKDRLPPEQSALFKALLKQICTFERDPGGRGVWVLKPEF 71
cc_ERCC-6_N cd21397
coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 ...
 83-159 2.48e-30

coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 (ERCC-6) and related proteins; This model represents a coiled-coil domain located near the N-terminus of ERCC-6 and related proteins. ERCC-6 (also known as Cockayne syndrome group B, CSB) is a DNA-binding protein important in eukaryotic transcription-coupled repair (TCR). TCR is a well-conserved sub-pathway of nucleotide excision repair (NER) that preferentially removes DNA lesions from the template strand blocking translocation of RNA polymerase II (Pol II). In a model for TCR, the processing Pol II encounters the lesion on the transcribed DNA strand and stalls; it is then displaced by the TCR-initiation complex which includes ERCC-6, ERCC-8, UVSSA and USP7; TCR-specific factors then access the lesion for the DNA damage incision process. The N-terminal region, the ATPase domain and the C-terminal region of ERCC-6 all directly contribute to DNA association and catalytic activity. The ATPase domain functions in concert with either the N- or C-terminal region to mediate UV-induced chromatin association. The N-terminal region prevents ERCC-6 from stably associating with chromatin under normal growth conditions, and the C-terminal region of ERCC-6 promotes stable chromatin association in the presence of lesion-stalled transcription. In addition to this coiled-coil domain, the N-terminal region of ERCC-6 includes two lysine residues subject to SUMOylation, a nucleolar localization signal NoLS1, and a nuclear localization signal NLS1. ERCC-6 also includes a SWI/SNF-like ATPase domain, a nucleotide-binding domain and a ubiquitin-binding domain. This coiled-coil domain binds magnesium. This domain family does not include Saccharomyces cerevisiae RAD26, and Schizosaccharomyces pombe Rhp26.


Pssm-ID: 411064 [Multi-domain]  Cd Length: 77  Bit Score: 115.00  E-value: 2.48e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231856   83 VEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSP 159
Cdd:cd21397      1 VPESDQASELQGLGVDVYDQDEFEQGVLQQVDQAIAEEEEERRKKDAEKELKSVLDDIRSVKQDLEHIEKVLEQLEP 77
DEXDc smart00487
DEAD-like helicases superfamily;
495-703 7.72e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 112.20  E-value: 7.72e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856   495 VPGFLFKKLFKYQQTGVRWLWELHCqqaGGILGDEMGLGKTIQIIAFLAglsyskirtrgSNYRFEGLGPTIIVCPTTV- 573
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPAL-----------EALKRGKGGRVLVLVPTREl 66

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856   574 MHQWVKEFHTWWPPFRVAVLHETGSYThKKERLIRDIVYCHGVLITSYSYIR--LMQDDISRHDWHYVILDEGHKIRNPN 651
Cdd:smart00487   67 AEQWAEELKKLGPSLGLKVVGLYGGDS-KREQLRKLESGKTDILVTTPGRLLdlLENDKLSLSNVDLVILDEAHRLLDGG 145

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856   652 AAVTLACKQFRTP---HRIILSGSP---MQNNLRELWSLFDFIFPGKLGTLPVfmEQF 703
Cdd:smart00487  146 FGDQLEKLLKLLPknvQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPI--EQF 201
46 PHA02562
endonuclease subunit; Provisional
 122-199 3.17e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 3.17e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  122 CVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAIL 199
Cdd:PHA02562   290 CTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAI 367
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 280-983 5.97e-142

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 451.22  E-value: 5.97e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  280 AQLSFERKKQAATKRTAKKAIVISESSRAAIETKADQRSQVLSQTDKRLKKHSRKLQRRALQFQGKVGLPSGKKPLEPEV 359
Cdd:COG0553     16 LLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  360 RPEAEGDTEGEESGSSPTDGEEEEEQEEEEGVASLSSDDVSYELKPLRKR-QKYQKKVPVQEIDDDFFPSSEEEDEAMEG 438
Cdd:COG0553     96 LLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALlLLLLLLLLLALLLGRLLLLALLLLALEAL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  439 RGGGRKVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEESDAE--FDEGFKVPGFLFKKLFKYQQTGVRWLWE 516
Cdd:COG0553    176 LLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRrlREALESLPAGLKATLRPYQLEGAAWLLF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  517 LHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskiRTRGSNyrfeglGPTIIVCPTTVMHQWVKEFHTWWPPFRVAVLHET 596
Cdd:COG0553    256 LRRLGLGGLLADDMGLGKTIQALALLLEL-----KERGLA------RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  597 GSyTHKKERLIRDivycHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQN 676
Cdd:COG0553    325 RE-RAKGANPFED----ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVEN 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  677 NLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASpvqvktaykcacVLRDTINPYLLRRMKSDVKmsLSLPDKN 756
Cdd:COG0553    400 RLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALE------------RLRRLLRPFLLRRTKEDVL--KDLPEKT 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  757 EQVLFCRLTDEQHKVYQNFIDskAVYRILNGEN------QIFSGLVALRKICNHPDLFSGgpknasgppedelEEEQFGH 830
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLE--YLRRELEGAEgirrrgLILAALTRLRQICSHPALLLE-------------EGAELSG 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  831 WrrSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTT 910
Cdd:COG0553    531 R--SAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767231856  911 RVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVL 983
Cdd:COG0553    609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 503-690 2.54e-119

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 371.27  E-value: 2.54e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyrfEGLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18000      1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSK----------LGLGPSLIVCPATVLKQWVKEFH 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLHETGSYTHKKE---------RLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:cd18000     71 RWWPPFRVVVLHSSGSGTGSEEklgsierksQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAE 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFP 690
Cdd:cd18000    151 ITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 506-808 1.92e-115

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 364.70  E-value: 1.92e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQ-QAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFHTW 584
Cdd:pfam00176    1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGG---------PTLIVVPLSLLHNWMNEFERW 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  585 W--PPFRVAVLHETGSYTHKkERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFR 662
Cdd:pfam00176   72 VspPALRVVVLHGNKRPQER-WKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  663 TPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGysnaspvqvktAYKCACVLRDTINPYLLRRM 742
Cdd:pfam00176  151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGG-----------GKKGVSRLHKLLKPFLLRRT 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231856  743 KSDVkmSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGEN------QIFSGLVALRKICNHPDLF 808
Cdd:pfam00176  220 KKDV--EKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGgreikaSLLNILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 354-971 6.76e-90

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 316.36  E-value: 6.76e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  354 PLEPEVRPEAE-GDTEGEESGSSPTDGEEEEeqeeeeGVASLSSDDVSYELKPLRKRQKYQKKVPVQEIDDDffpSSEEE 432
Cdd:PLN03142    17 ELEAVARSAGSdSDDDEVPAEDEDEDEEDDE------EAESPAKAEISKREKARLKELKKQKKQEIQKILEQ---QNAAI 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  433 DEAMEGRGGGR-KVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEesDAEF----DEGFKV---------PGF 498
Cdd:PLN03142    88 DADMNNKGKGRlKYLLQQTEIFAHFAKGDQSASAKKAKGRGRHASKLTEEEE--DEEYlkeeEDGLGGsggtrllvqPSC 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  499 LFKKLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskirtrgsnYRFEGL-GPTIIVCPTTVMHQW 577
Cdd:PLN03142   166 IKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYL-----------HEYRGItGPHMVVAPKSTLGNW 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  578 VKEFHTWWPPFRVAVLHETgsythKKERLIRDIVYCHG----VLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:PLN03142   235 MNEIRRFCPVLRAVKFHGN-----PEERAHQREELLVAgkfdVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSL 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitMGGYSNASPVqVKTAYKcacVLRdt 733
Cdd:PLN03142   310 LSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ----ISGENDQQEV-VQQLHK---VLR-- 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  734 inPYLLRRMKSDVKMSLslPDKNEQVLFCRLTDEQHKVYQNFI--DSKAV------YRILNGENQifsglvaLRKICNHP 805
Cdd:PLN03142   380 --PFLLRRLKSDVEKGL--PPKKETILKVGMSQMQKQYYKALLqkDLDVVnaggerKRLLNIAMQ-------LRKCCNHP 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  806 DLFSGGpknASGPP---EDELEEEqfghwrrSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMD 882
Cdd:PLN03142   449 YLFQGA---EPGPPyttGEHLVEN-------SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRID 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  883 GTTTIASRQPLITKYN-EDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTA 961
Cdd:PLN03142   519 GNTGGEDRDASIDAFNkPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTE 598

                          650
                   ....*....|
gi 1767231856  962 GTIEEKIYHR 971
Cdd:PLN03142   599 YTIEEKVIER 608
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 503-690 1.52e-73

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 242.47  E-value: 1.52e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfegLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd17919      1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKE----------RGPVLVVCPLSVLENWEREFE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLHetGSYTHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFR 662
Cdd:cd17919     71 KWTPDLRVVVYH--GSQRERAQIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALR 148

                          170       180
                   ....*....|....*....|....*...
gi 1767231856  663 TPHRIILSGSPMQNNLRELWSLFDFIFP 690
Cdd:cd17919    149 AKRRLLLTGTPLQNNLEELWALLDFLDP 176
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 503-741 1.25e-71

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 239.20  E-value: 1.25e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRgsnyrfeglgpTIIVCPTTVMHQWVKEFH 582
Cdd:cd18001      1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKS-----------VLVVMPTSLIPHWVKEFA 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLHetGSYTHKKERLIRDIVYCHGVLITSYSYIR-----LMQDDISRHDWHYVILDEGHKIRNPNAAVTLA 657
Cdd:cd18001     70 KWTPGLRVKVFH--GTSKKERERNLERIQRGGGVLLTTYGMVLsnteqLSADDHDEFKWDYVILDEGHKIKNSKTKSAKS 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  658 CKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGK-LGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINP 736
Cdd:cd18001    148 LREIPAKNRIILTGTPIQNNLKELWALFDFACNGSlLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKP 227


                   ....*
gi 1767231856  737 YLLRR 741
Cdd:cd18001    228 YFLRR 232
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 506-743 2.81e-67

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 226.29  E-value: 2.81e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAglsyskirtrgSNYRFEGLGPTIIVCPTTVMHQWVKEFHTWW 585
Cdd:cd18012      8 YQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLL-----------SRKEEGRKGPSLVVAPTSLIYNWEEEAAKFA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  586 PPFRVAVLHETgsythKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPH 665
Cdd:cd18012     77 PELKVLVIHGT-----KRKREKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADH 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  666 RIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPvqvktaykcacVLRDTINPYLLRRMK 743
Cdd:cd18012    152 RLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEALE-----------ELKKLISPFILRRLK 218
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 503-741 4.09e-63

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 214.91  E-value: 4.09e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAglsySKIRTRGSNYRFEGLgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd17999      1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILA----SDHHKRANSFNSENL-PSLVVCPPTLVGHWVAEIK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLHETGSYThkKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFR 662
Cdd:cd17999     76 KYFPNAFLKPLAYVGPPQ--ERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLK 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767231856  663 TPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRR 741
Cdd:cd17999    154 ANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 834-959 2.99e-60

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 202.71  E-value: 2.99e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  834 SGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVG 913
Cdd:cd18793     10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1767231856  914 GLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLL 959
Cdd:cd18793     90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 506-741 1.07e-58

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 202.61  E-value: 1.07e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsYSKIRTRGSNYRFEGL-----------GPTIIVCPTTVM 574
Cdd:cd18005      4 YQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAV-LGKTGTRRDRENNRPRfkkkppassakKPVLIVAPLSVL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  575 HQWVKEFHTW-WppFRVAVLHETGSYTHKKERLIRDIVychGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:cd18005     83 YNWKDELDTWgH--FEVGVYHGSRKDDELEGRLKAGRL---EVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDT 733
Cdd:cd18005    158 LTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVK 237


                   ....*...
gi 1767231856  734 INPYLLRR 741
Cdd:cd18005    238 LSKFFLRR 245
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 507-725 9.48e-48

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 170.94  E-value: 9.48e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  507 QQTGVRWLWE-----LHCQQAGG--ILGDEMGLGKTIQIIAFL-AGLSYSKIRTRgsnyrfeglgpTIIVCPTTVMHQWV 578
Cdd:cd18007      5 QVEGVRFLWSnlvgtDVGSDEGGgcILAHTMGLGKTLQVITFLhTYLAAAPRRSR-----------PLVLCPASTLYNWE 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  579 KEFHTWWPPFRVAVLHETGSYTHKKERLIRDIVYC-H---GVLITSY-SYIRLMQDDISRHDWHY-------------VI 640
Cdd:cd18007     74 DEFKKWLPPDLRPLLVLVSLSASKRADARLRKINKwHkegGVLLIGYeLFRNLASNATTDPRLKQefiaalldpgpdlLV 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  641 LDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQV 720
Cdd:cd18007    154 LDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDV 233


                   ....*
gi 1767231856  721 KTAYK 725
Cdd:cd18007    234 RLMLK 238
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 503-741 1.21e-47

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 170.23  E-value: 1.21e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyrfEGLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18003      1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEK----------GNWGPHLIVVPTSVMLNWEMEFK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRvaVLHETGSytHKKERLIRD---IVYCHGVLITSYSYIrlMQDDIS--RHDWHYVILDEGHKIRNPNAAVTLA 657
Cdd:cd18003     71 RWCPGFK--ILTYYGS--AKERKLKRQgwmKPNSFHVCITSYQLV--VQDHQVfkRKKWKYLILDEAHNIKNFKSQRWQT 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  658 CKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITmggysnaSPVQVKTAYKCACV--LRDTIN 735
Cdd:cd18003    145 LLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLT-------AMSEGSQEENEELVrrLHKVLR 217


                   ....*.
gi 1767231856  736 PYLLRR 741
Cdd:cd18003    218 PFLLRR 223
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 506-743 4.43e-46

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 166.02  E-value: 4.43e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskiRTRGSnyrfegLGPTIIVCPTTVMHQWVKEFHTWW 585
Cdd:cd18009      7 YQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHL-----RERGV------WGPFLVIAPLSTLPNWVNEFARFT 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  586 PPFRVAVLHETGSYthkKERLIRDIVY------CHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACK 659
Cdd:cd18009     76 PSVPVLLYHGTKEE---RERLRKKIMKregtlqDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELK 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  660 QFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLL 739
Cdd:cd18009    153 TFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLL 232


                   ....
gi 1767231856  740 RRMK 743
Cdd:cd18009    233 RRLK 236
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 502-743 9.59e-46

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 164.42  E-value: 9.59e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLS-YSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKE 580
Cdd:cd17997      3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKhYKNIN-----------GPHLIIVPKSTLDNWMRE 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  581 FHTWWPPFRVAVLHetgsyTHKKER--LIRDiVYCHG---VLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVT 655
Cdd:cd17997     72 FKRWCPSLRVVVLI-----GDKEERadIIRD-VLLPGkfdVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLS 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  656 LACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNAspvqVKTAYKcacVLRdtin 735
Cdd:cd17997    146 QIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEV----VQRLHK---VLR---- 214


                   ....*...
gi 1767231856  736 PYLLRRMK 743
Cdd:cd17997    215 PFLLRRIK 222
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 507-741 2.48e-45

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 164.00  E-value: 2.48e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  507 QQTGVRWLWE-LHCQQAGG----ILGDEMGLGKTIQIIAflagLSYSKIRTRgsnyrfEGLGPT----IIVCPTTVMHQW 577
Cdd:cd18004      5 QREGVQFLYDcLTGRRGYGgggaILADEMGLGKTLQAIA----LVWTLLKQG------PYGKPTakkaLIVCPSSLVGNW 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  578 VKEFHTWWPPFRVAVLHETGS--YTHKKERLIRDIVYCHgVLITSYSYIRLMQDDISR-HDWHYVILDEGHKIRNPNAAV 654
Cdd:cd18004     75 KAEFDKWLGLRRIKVVTADGNakDVKASLDFFSSASTYP-VLIISYETLRRHAEKLSKkISIDLLICDEGHRLKNSESKT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  655 TLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTI 734
Cdd:cd18004    154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELT 233


                   ....*..
gi 1767231856  735 NPYLLRR 741
Cdd:cd18004    234 SRFILRR 240
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 502-743 8.46e-45

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 162.15  E-value: 8.46e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsyskIRTRGSNyrfeglGPTIIVCPTTVMHQWVKEF 581
Cdd:cd17996      3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYL----MEKKKNN------GPYLVIVPLSTLSNWVSEF 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  582 HTWWPPFRVAVLHETGSYTHKKERLIRDIVYchGVLITSYSYIrlMQDD--ISRHDWHYVILDEGHKIRNPNAAVTLACK 659
Cdd:cd17996     73 EKWAPSVSKIVYKGTPDVRKKLQSQIRAGKF--NVLLTTYEYI--IKDKplLSKIKWKYMIIDEGHRMKNAQSKLTQTLN 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  660 Q-FRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPV----QVKTAYKCACVLRdti 734
Cdd:cd17996    149 TyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELneeeTLLIIRRLHKVLR--- 225


                   ....*....
gi 1767231856  735 nPYLLRRMK 743
Cdd:cd17996    226 -PFLLRRLK 233
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 506-741 1.07e-44

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 161.65  E-value: 1.07e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLweLHC--QQAGGILGDEMGLGKTIQIIAFLaglsySKIRTRGsNYRfeglGPTIIVCPTTVMHQWVKEFHT 583
Cdd:cd17995      4 YQLEGVNWL--LFNwyNRRNCILADEMGLGKTIQSIAFL-----EHLYQVE-GIR----GPFLVIAPLSTIPNWQREFET 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  584 WwPPFRVAVLHETGS----------YTHKKERLIRDIVYCHGVLITSYSYIrlMQD--DISRHDWHYVILDEGHKIRNPN 651
Cdd:cd17995     72 W-TDMNVVVYHGSGEsrqiiqqyemYFKDAQGRKKKGVYKFDVLITTYEMV--IADaeELRKIPWRVVVVDEAHRLKNRN 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  652 AAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFsvpitmGGYSNASPVQvktaykcacVLR 731
Cdd:cd17995    149 SKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF------GDLKTAEQVE---------KLQ 213

                          250
                   ....*....|
gi 1767231856  732 DTINPYLLRR 741
Cdd:cd17995    214 ALLKPYMLRR 223
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 503-741 6.93e-43

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 157.06  E-value: 6.93e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLweLHCqqaGGILGDEMGLGKTIQIIAF-LAGLSYSKIRTRGSNYRFEGL------GPTIIVCPTTVMH 575
Cdd:cd18008      1 LLPYQKQGLAWM--LPR---GGILADEMGLGKTIQALALiLATRPQDPKIPEELEENSSDPkklylsKTTLIVVPLSLLS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  576 QWVKEF--HTWWPPFRVAVLHETGSYTHKKERLIRDIVychgvlITSYSyiRLMQDD------------------ISRHD 635
Cdd:cd18008     76 QWKDEIekHTKPGSLKVYVYHGSKRIKSIEELSDYDIV------ITTYG--TLASEFpknkkgggrdskekeaspLHRIR 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  636 WHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNA 715
Cdd:cd18008    148 WYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRKAL 227

                          250       260
                   ....*....|....*....|....*.
gi 1767231856  716 SPVQVktaykcacvlrdTINPYLLRR 741
Cdd:cd18008    228 ERLQA------------LLKPILLRR 241
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 502-741 2.39e-39

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 145.96  E-value: 2.39e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyrfEGLGPTIIVCPTTVMHQWVKEF 581
Cdd:cd17993      1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQ----------QQYGPFLVVVPLSTMPAWQREF 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  582 HTWWPPFRVAVLheTGSYTHKKerLIRDIVYCHG--------VLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:cd17993     71 AKWAPDMNVIVY--LGDIKSRD--TIREYEFYFSqtkklkfnVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESL 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQfsvpitmggYSNASPVQVKTaykcacvLRDT 733
Cdd:cd17993    147 LYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEE---------HDEEQEKGIAD-------LHKE 210


                   ....*...
gi 1767231856  734 INPYLLRR 741
Cdd:cd17993    211 LEPFILRR 218
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 503-741 4.57e-39

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 145.27  E-value: 4.57e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWE-LHCQQaGGILGDEMGLGKTIQIIAFLAGLSYskirtrgsnyRFEGLGPTIIVCPTTVMHQWVKEF 581
Cdd:cd18006      1 LRPYQLEGVNWLLQcRAEQH-GCILGDEMGLGKTCQTISLLWYLAG----------RLKLLGPFLVLCPLSVLDNWKEEL 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  582 HTWWPpfRVAVLHETGSythKKERL-----IRDIVYCHgVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTL 656
Cdd:cd18006     70 NRFAP--DLSVITYMGD---KEKRLdlqqdIKSTNRFH-VLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHK 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  657 ACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLG--TLPVFMEQFSvpitmggysnaspvQVKTAYKCACVLRDTI 734
Cdd:cd18006    144 TLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPkdKLDDFIKAYS--------------ETDDESETVEELHLLL 209


                   ....*..
gi 1767231856  735 NPYLLRR 741
Cdd:cd18006    210 QPFLLRR 216
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 506-721 5.43e-38

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 142.65  E-value: 5.43e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQA---------GGILGDEMGLGKTIQIIAFLAGLsyskirtrgsnYRFEGLGPTIIVCPTTVMHQ 576
Cdd:cd18069      4 HQIGGIRFLYDNIIESLerykgssgfGCILAHSMGLGKTLQVISFLDVL-----------LRHTGAKTVLAIVPVNTLQN 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  577 WVKEFHTWWPP-----------FRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYIRLmqddisRHDWHYVILDEGH 645
Cdd:cd18069     73 WLSEFNKWLPPpealpnvrprpFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFRL------RPGPDVVICDEGH 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1767231856  646 KIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVK 721
Cdd:cd18069    147 RIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVK 222
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 506-690 1.28e-37

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 139.83  E-value: 1.28e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKEFHTWW 585
Cdd:cd17998      4 YQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIP-----------GPHLVVVPSSTLDNWLREFKRWC 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  586 PPFRVAVLHetGSYTHKKErlIRDIVYC----HGVLITSYSYIRLMQDDIS---RHDWHYVILDEGHKIRNPNAAVTLAC 658
Cdd:cd17998     73 PSLKVEPYY--GSQEERKH--LRYDILKgledFDVIVTTYNLATSNPDDRSffkRLKLNYVVYDEGHMLKNMTSERYRHL 148

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1767231856  659 KQFRTPHRIILSGSPMQNNLRELWSLFDFIFP 690
Cdd:cd17998    149 MTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 502-750 1.46e-37

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 141.73  E-value: 1.46e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYskirtrgsnYRfEGLGPTIIVCPTTVMHQWVKEF 581
Cdd:cd18064     15 KLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKH---------YR-NIPGPHMVLVPKSTLHNWMAEF 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  582 HTWWPPFRVAVLheTGSyTHKKERLIRDIVYCH--GVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACK 659
Cdd:cd18064     85 KRWVPTLRAVCL--IGD-KDQRAAFVRDVLLPGewDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  660 QFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGgysnaspvQVKTAYKCACVLRdtinPYLL 739
Cdd:cd18064    162 EFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLG--------DQKLVERLHMVLR----PFLL 229

                          250
                   ....*....|.
gi 1767231856  740 RRMKSDVKMSL 750
Cdd:cd18064    230 RRIKADVEKSL 240
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 506-741 3.32e-36

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 137.67  E-value: 3.32e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWEL-----HCQQAGGILGDEMGLGKTIQIIAFLAGLsyskirTRGSNYrfeGLGP----TIIVCPTTVMHQ 576
Cdd:cd18066      4 HQREGIEFLYECvmgmrVNERFGAILADEMGLGKTLQCISLIWTL------LRQGPY---GGKPvikrALIVTPGSLVKN 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  577 WVKEFHTWWPPFRVAVLheTGSYTHKKERLIRDIVYchGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTL 656
Cdd:cd18066     75 WKKEFQKWLGSERIKVF--TVDQDHKVEEFIASPLY--SVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTT 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  657 ACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINP 736
Cdd:cd18066    151 ALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGL 230


                   ....*
gi 1767231856  737 YLLRR 741
Cdd:cd18066    231 FILRR 235
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 502-741 1.35e-33

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 130.13  E-value: 1.35e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYskirtrgsnyRFEGLGPTIIVCPTTVMHQWVKEF 581
Cdd:cd18054     20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFH----------QHQLYGPFLLVVPLSTLTSWQREF 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  582 HTWWPPFRVAV-LHETGSythkkERLIRDIVYCH--------GVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNA 652
Cdd:cd18054     90 EIWAPEINVVVyIGDLMS-----RNTIREYEWIHsqtkrlkfNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDS 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  653 AVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitmGGYSNaspvqvktAYKCacvLRD 732
Cdd:cd18054    165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHG-----KGREN--------GYQS---LHK 228


                   ....*....
gi 1767231856  733 TINPYLLRR 741
Cdd:cd18054    229 VLEPFLLRR 237
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 503-743 2.00e-33

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 129.75  E-value: 2.00e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYskirtrgsnYRfEGLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18065     16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKH---------YR-NIPGPHMVLVPKSTLHNWMNEFK 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVLheTGSyTHKKERLIRDIVYCH--GVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQ 660
Cdd:cd18065     86 RWVPSLRAVCL--IGD-KDARAAFIRDVMMPGewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  661 FRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGysnaspvqvktaYKCACVLRDTINPYLLR 740
Cdd:cd18065    163 FKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGD------------QKLVERLHAVLKPFLLR 230


                   ...
gi 1767231856  741 RMK 743
Cdd:cd18065    231 RIK 233
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 503-743 4.00e-33

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 129.39  E-value: 4.00e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyRFEGlgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18062     24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHK--------RING--PFLIIVPLSTLSNWVYEFD 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPpfRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACK-QF 661
Cdd:cd18062     94 KWAP--SVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHY 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  662 RTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGysnaSPVQVKTAYKCACV--LRDTINPYLL 739
Cdd:cd18062    172 VAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG----EKVDLNEEETILIIrrLHKVLRPFLL 247


                   ....
gi 1767231856  740 RRMK 743
Cdd:cd18062    248 RRLK 251
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 503-743 8.35e-33

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 128.26  E-value: 8.35e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyRFEGlgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18063     24 LKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHK--------RLNG--PYLIIVPLSTLSNWTYEFD 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPpfRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACK-QF 661
Cdd:cd18063     94 KWAP--SVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHY 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  662 RTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGysnaSPVQVKTAYKCACV--LRDTINPYLL 739
Cdd:cd18063    172 VAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG----ERVDLNEEETILIIrrLHKVLRPFLL 247


                   ....
gi 1767231856  740 RRMK 743
Cdd:cd18063    248 RRLK 251
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 503-741 5.76e-32

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 125.31  E-value: 5.76e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKirtrgsnyrfEGLGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18002      1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEH----------NIWGPFLVIAPASTLHNWQQEIS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVavLHETGS---------YTHKKERLIRDIVYcHgVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAA 653
Cdd:cd18002     71 RFVPQFKV--LPYWGNpkdrkvlrkFWDRKNLYTRDAPF-H-VVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSS 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  654 VTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPIT--MGGYSNASPVQVKTaykcacvLR 731
Cdd:cd18002    147 RWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEshAENKTGLNEHQLKR-------LH 219

                          250
                   ....*....|
gi 1767231856  732 DTINPYLLRR 741
Cdd:cd18002    220 MILKPFMLRR 229
CSB_WHD cd22254
winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, ...
 1410-1480 2.62e-31

winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, also called cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, ERCC Excision Repair 6, or ATP-dependent helicase ERCC6, is involved in many DNA repair processes and is essential for transcription-coupled repair (TCR). It regulates DNA double-strand break (DSB) repair and checkpoint activation. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for TCR complex formation. CSB also regulates transcription and chromatin remodeling activities that are essential for neuronal differentiation and neuritogenesis. This model corresponds to the winged-helix domain (WHD) of CSB, which is involved in the recruitment of CSB to DSBs. The CSB WHD folds as a single globular domain, defining a class of ubiquitin-binding domains (UBDs) different from other UBD classes.


Pssm-ID: 439329  Cd Length: 72  Bit Score: 117.61  E-value: 2.62e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767231856 1410 TEHDDLLVDMRNFIAFQAqvDGQASTQEILQEFESKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEY 1480
Cdd:cd22254      3 TEAEELLADIRDFLAFQA--GGQATTDEIVDHFKDRLPPEQSALFKALLKQICTFERDPGGRGVWVLKPEF 71
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 506-721 3.65e-31

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 123.46  E-value: 3.65e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWELHCQQ---------AGGILGDEMGLGKTIQIIAFLaglsyskiRTRGSNYRFEGLGPTIIVCPTTVMHQ 576
Cdd:cd18068      4 HQVDGVQFMWDCCCESlkktkkspgSGCILAHCMGLGKTLQVVTFL--------HTVLLCEKLENFSRVLVVCPLNTVLN 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  577 WVKEFHTWWPPFR---VAVLHETGSYTHKKERLIRDIVYCH--GVLITSYSYIRLM--QDDIS-----RHDWH------- 637
Cdd:cd18068     76 WLNEFEKWQEGLKdeeKIEVNELATYKRPQERSYKLQRWQEegGVMIIGYDMYRILaqERNVKsreklKEIFNkalvdpg 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  638 --YVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNA 715
Cdd:cd18068    156 pdFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADS 235


                   ....*.
gi 1767231856  716 SPVQVK 721
Cdd:cd18068    236 TLVDVR 241
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 503-741 3.90e-31

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 121.78  E-value: 3.90e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd17994      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSL-YKEGHSKG---------PFLVSAPLSTIINWEREFE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVavlhetgsythkkerlirdIVYC--HgVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQ 660
Cdd:cd17994     71 MWAPDFYV-------------------VTYVgdH-VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNS 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  661 FRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPitmggysnASPVQVKTaykcacvLRDTINPYLLR 740
Cdd:cd17994    131 YKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADI--------SKEDQIKK-------LHDLLGPHMLR 195


                   .
gi 1767231856  741 R 741
Cdd:cd17994    196 R 196
cc_ERCC-6_N cd21397
coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 ...
 83-159 2.48e-30

coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 (ERCC-6) and related proteins; This model represents a coiled-coil domain located near the N-terminus of ERCC-6 and related proteins. ERCC-6 (also known as Cockayne syndrome group B, CSB) is a DNA-binding protein important in eukaryotic transcription-coupled repair (TCR). TCR is a well-conserved sub-pathway of nucleotide excision repair (NER) that preferentially removes DNA lesions from the template strand blocking translocation of RNA polymerase II (Pol II). In a model for TCR, the processing Pol II encounters the lesion on the transcribed DNA strand and stalls; it is then displaced by the TCR-initiation complex which includes ERCC-6, ERCC-8, UVSSA and USP7; TCR-specific factors then access the lesion for the DNA damage incision process. The N-terminal region, the ATPase domain and the C-terminal region of ERCC-6 all directly contribute to DNA association and catalytic activity. The ATPase domain functions in concert with either the N- or C-terminal region to mediate UV-induced chromatin association. The N-terminal region prevents ERCC-6 from stably associating with chromatin under normal growth conditions, and the C-terminal region of ERCC-6 promotes stable chromatin association in the presence of lesion-stalled transcription. In addition to this coiled-coil domain, the N-terminal region of ERCC-6 includes two lysine residues subject to SUMOylation, a nucleolar localization signal NoLS1, and a nuclear localization signal NLS1. ERCC-6 also includes a SWI/SNF-like ATPase domain, a nucleotide-binding domain and a ubiquitin-binding domain. This coiled-coil domain binds magnesium. This domain family does not include Saccharomyces cerevisiae RAD26, and Schizosaccharomyces pombe Rhp26.


Pssm-ID: 411064 [Multi-domain]  Cd Length: 77  Bit Score: 115.00  E-value: 2.48e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231856   83 VEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSP 159
Cdd:cd21397      1 VPESDQASELQGLGVDVYDQDEFEQGVLQQVDQAIAEEEEERRKKDAEKELKSVLDDIRSVKQDLEHIEKVLEQLEP 77
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 506-741 7.67e-29

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 116.80  E-value: 7.67e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  506 YQQTGVRWLWElhCQQA-------GGILGDEMGLGKTIQIIAFLAGLsyskirTRGSNYRFEGLGPTIIVCPTTVMHQWV 578
Cdd:cd18067      4 HQREGVKFLYR--CVTGrrirgshGCIMADEMGLGKTLQCITLMWTL------LRQSPQCKPEIDKAIVVSPSSLVKNWA 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  579 KEFHTWWPPFRVAVLHETGSythKKERLIRDIVYC--HG------VLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNP 650
Cdd:cd18067     76 NELGKWLGGRLQPLAIDGGS---KKEIDRKLVQWAsqQGrrvstpVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  651 NAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVL 730
Cdd:cd18067    153 DNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQEL 232

                          250
                   ....*....|.
gi 1767231856  731 RDTINPYLLRR 741
Cdd:cd18067    233 ISIVNRCIIRR 243
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 502-741 2.21e-28

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 115.15  E-value: 2.21e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLaglsyskirtrgsNYRF---EGLGPTIIVCPTTVMHQWV 578
Cdd:cd18053     20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL-------------NYLFhehQLYGPFLLVVPLSTLTSWQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  579 KEFHTWWPPFRVAV---------LHETGSYTHKKERLIRdivycHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRN 649
Cdd:cd18053     87 REIQTWAPQMNAVVylgdinsrnMIRTHEWMHPQTKRLK-----FNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKN 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  650 PNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSnaspvqvktaykcacv 729
Cdd:cd18053    162 DDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYAS---------------- 225

                          250
                   ....*....|..
gi 1767231856  730 LRDTINPYLLRR 741
Cdd:cd18053    226 LHKELEPFLLRR 237
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 503-741 4.02e-28

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 114.34  E-value: 4.02e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18055      1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSL-YKEGHTKG---------PFLVSAPLSTIINWEREFQ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRV----------AVLHETG-SYT-------HKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEG 644
Cdd:cd18055     71 MWAPDFYVvtytgdkdsrAIIRENEfSFDdnavkggKKAFKMKREAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  645 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitmggySNASPVQVKTay 724
Cdd:cd18055    151 HRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA--------DISKEDQIKK-- 220

                          250
                   ....*....|....*..
gi 1767231856  725 kcacvLRDTINPYLLRR 741
Cdd:cd18055    221 -----LHDLLGPHMLRR 232
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 503-741 4.41e-28

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 113.60  E-value: 4.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18058      1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIR-----------GPFLIIAPLSTITNWEREFR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWwPPFRVAVLHETG---SYTHKKERLIRDI-------VYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNA 652
Cdd:cd18058     70 TW-TEMNAIVYHGSQisrQMIQQYEMYYRDEqgnplsgIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNC 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  653 AVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitmggySNASPVQVKTaykcacvLRD 732
Cdd:cd18058    149 KLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG--------DLKTEEQVKK-------LQS 213


                   ....*....
gi 1767231856  733 TINPYLLRR 741
Cdd:cd18058    214 ILKPMMLRR 222
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 503-731 6.15e-28

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 113.07  E-value: 6.15e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRW-LwelhcqQAGG--ILGDEMGLGKTIQIIAFLAglsyskirtrgsNYRFEGlgPTIIVCPTTVMHQWVK 579
Cdd:cd18010      1 LLPFQREGVCFaL------RRGGrvLIADEMGLGKTVQAIAIAA------------YYREEW--PLLIVCPSSLRLTWAD 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  580 EFHTWwppFRVAVLHETGSYTHKKERLIRDIvycHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACK 659
Cdd:cd18010     61 EIERW---LPSLPPDDIQVIVKSKDGLRDGD---AKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAAL 134

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  660 QF--RTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGY----SNASPVQVKTAYKCACVLR 731
Cdd:cd18010    135 PLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFGwdysGSSNLEELHLLLLATIMIR 212
DEXDc smart00487
DEAD-like helicases superfamily;
495-703 7.72e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 112.20  E-value: 7.72e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856   495 VPGFLFKKLFKYQQTGVRWLWELHCqqaGGILGDEMGLGKTIQIIAFLAglsyskirtrgSNYRFEGLGPTIIVCPTTV- 573
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPAL-----------EALKRGKGGRVLVLVPTREl 66

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856   574 MHQWVKEFHTWWPPFRVAVLHETGSYThKKERLIRDIVYCHGVLITSYSYIR--LMQDDISRHDWHYVILDEGHKIRNPN 651
Cdd:smart00487   67 AEQWAEELKKLGPSLGLKVVGLYGGDS-KREQLRKLESGKTDILVTTPGRLLdlLENDKLSLSNVDLVILDEAHRLLDGG 145

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856   652 AAVTLACKQFRTP---HRIILSGSP---MQNNLRELWSLFDFIFPGKLGTLPVfmEQF 703
Cdd:smart00487  146 FGDQLEKLLKLLPknvQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPI--EQF 201
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 503-741 2.61e-27

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 111.70  E-value: 2.61e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18057      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSL-YKEGHSKG---------PYLVSAPLSTIINWEREFE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRVAVL---HETGSYTHKKE---------------RLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEG 644
Cdd:cd18057     71 MWAPDFYVVTYtgdKESRSVIRENEfsfednairsgkkvfRMKKEAQIKFHVLLTSYELITIDQAILGSIEWACLVVDEA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  645 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitmggySNASPVQVKTay 724
Cdd:cd18057    151 HRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA--------DISKEDQIKK-- 220

                          250
                   ....*....|....*..
gi 1767231856  725 kcacvLRDTINPYLLRR 741
Cdd:cd18057    221 -----LHDLLGPHMLRR 232
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 835-948 4.48e-26

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 103.83  E-value: 4.48e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  835 GKMIVVESLLKiwHRQGQRVLLFSQSRQMLHIlEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTsiFVFLLTTRVGG 914
Cdd:pfam00271    1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1767231856  915 LGVNLTGANRVIIYDPDWNPSTDTQARERAWRIG 948
Cdd:pfam00271   76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 503-703 4.81e-26

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 107.81  E-value: 4.81e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18059      1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIH-----------GPFLVIAPLSTIPNWEREFR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWwPPFRVAVLHETGS-----------YTHKKERLIRDIVYCHGVlITSYSYIRLMQDDISRHDWHYVILDEGHKIRNPN 651
Cdd:cd18059     70 TW-TELNVVVYHGSQAsrrtiqlyemyFKDPQGRVIKGSYKFHAI-ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRN 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1767231856  652 AAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQF 703
Cdd:cd18059    148 CKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF 199
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 503-741 5.33e-26

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 108.23  E-value: 5.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLsYSKIRTRGsnyrfeglgPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18056      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSL-YKEGHSKG---------PFLVSAPLSTIINWEREFE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWWPPFRV----------AVLHETG-SYT-------HKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEG 644
Cdd:cd18056     71 MWAPDMYVvtyvgdkdsrAIIRENEfSFEdnairggKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  645 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSvpitmggySNASPVQVKTay 724
Cdd:cd18056    151 HRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA--------DIAKEDQIKK-- 220

                          250
                   ....*....|....*..
gi 1767231856  725 kcacvLRDTINPYLLRR 741
Cdd:cd18056    221 -----LHDMLGPHMLRR 232
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 503-703 1.82e-25

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 106.24  E-value: 1.82e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18061      1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIR-----------GPFLIIAPLSTIANWEREFR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWwPPFRVAVLHetGSYTHKKE-------------RLIRDiVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRN 649
Cdd:cd18061     70 TW-TDLNVVVYH--GSLISRQMiqqyemyfrdsqgRIIRG-AYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKN 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1767231856  650 PNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQF 703
Cdd:cd18061    146 KNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF 199
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 503-688 4.10e-25

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 105.64  E-value: 4.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWL-WELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRG-------------SNYRFEGLGpTIIV 568
Cdd:cd18072      1 LLLHQKQALAWLlWRERQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEEekekalteweskkDSTLVPSAG-TLVV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  569 CPTTVMHQWVKEF--HTWWPPFRVAVLHetGSYTHKKERLIRDivycHGVLITSYSYI-----RLMQDDIS----RHDWH 637
Cdd:cd18072     80 CPASLVHQWKNEVesRVASNKLRVCLYH--GPNRERIGEVLRD----YDIVITTYSLVakeipTYKEESRSsplfRIAWA 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1767231856  638 YVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFI 688
Cdd:cd18072    154 RIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 523-720 5.61e-25

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 105.24  E-value: 5.61e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  523 GGILGDEMGLGKTIQIIAFLAGlsyskirtrgsnyrfeglGPTIIVCPTTVMHQWVKEF--HTWWPPFRVAVLHETGSYT 600
Cdd:cd18071     50 GGILADDMGLGKTLTTISLILA------------------NFTLIVCPLSVLSNWETQFeeHVKPGQLKVYTYHGGERNR 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  601 HKKERLIRDIVychgvlITSYSYirLMQDDISRHD-------WHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSP 673
Cdd:cd18071    112 DPKLLSKYDIV------LTTYNT--LASDFGAKGDsplhtinWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTP 183

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1767231856  674 MQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQV 720
Cdd:cd18071    184 IQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTGLKRLQV 230
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 503-741 6.75e-25

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 104.75  E-value: 6.75e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRtrgsnyrfeglGPTIIVCPTTVMHQWVKEFH 582
Cdd:cd18060      1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIH-----------GPFLVIAPLSTITNWEREFN 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  583 TWwPPFRVAVLHetGSYTHK-------------KERLIRDiVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEGHKIRN 649
Cdd:cd18060     70 TW-TEMNTIVYH--GSLASRqmiqqyemyckdsRGRLIPG-AYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKN 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  650 PNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFsvpitmGGYSNASPVQvktaykcacV 729
Cdd:cd18060    146 RNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF------GDLKTEEQVQ---------K 210

                          250
                   ....*....|..
gi 1767231856  730 LRDTINPYLLRR 741
Cdd:cd18060    211 LQAILKPMMLRR 222
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 503-688 2.56e-22

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 98.18  E-value: 2.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWElhcqqAGGILGDEMGLGKTIQIIAFLA-------GLSYSKIRTRGSNYRFEGL--------GPTII 567
Cdd:cd18070      1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVEVLALILlhprpdnDLDAADDDSDEMVCCPDCLvaetpvssKATLI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  568 VCPTTVMHQWVKEFHTWWPPfRVAVLHETGSYTHKK------ERLIR-DIVychgvlITSYSYIR--LMQDDISRHD--- 635
Cdd:cd18070     76 VCPSAILAQWLDEINRHVPS-SLKVLTYQGVKKDGAlaspapEILAEyDIV------VTTYDVLRteLHYAEANRSNrrr 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  636 -----------------WHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFI 688
Cdd:cd18070    149 rrqkryeappsplvlveWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFL 218
HELICc smart00490
helicase superfamily c-terminal domain;
866-948 7.78e-20

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 85.34  E-value: 7.78e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856   866 ILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSifVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAW 945
Cdd:smart00490    2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79


                    ...
gi 1767231856   946 RIG 948
Cdd:smart00490   80 RAG 82
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 503-691 1.98e-18

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 85.42  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWELhcQQAGGILGDEMGLGKTIQiiaflAGL--SYSKIRTRGsnyrfeglGPTIIVCPTTVMHQWVKE 580
Cdd:cd18011      1 PLPHQIDAVLRALRK--PPVRLLLADEVGLGKTIE-----AGLiiKELLLRGDA--------KRVLILCPASLVEQWQDE 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  581 -FHTWWPPFRVAvlheTGSYTHKKERLIRDIVYCHGVLITSYSYIRlmQDDISRH-----DWHYVILDEGHKIRN-PNAA 653
Cdd:cd18011     66 lQDKFGLPFLIL----DRETAAQLRRLIGNPFEEFPIVIVSLDLLK--RSEERRGlllseEWDLVVVDEAHKLRNsGGGK 139

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1767231856  654 VTL---ACKQF--RTPHRIILSGSPMQNNLRELWSLFDFIFPG 691
Cdd:cd18011    140 ETKrykLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPG 182
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
429-673 5.98e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 57.34  E-value: 5.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  429 SEEEDEAMEGRGGGRKVARRQDDGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEESDAE-------FDEGFKVPGFLFK 501
Cdd:COG1061      1 VLLRGIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERelaeaeaLEAGDEASGTSFE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  502 kLFKYQQTGVRWLWELHCQQAG-GILgdEM--GLGKTIqIIAFLAglsyskirtrgsnYRFEGLGPTIIVCPTTV-MHQW 577
Cdd:COG1061     81 -LRPYQQEALEALLAALERGGGrGLV--VAptGTGKTV-LALALA-------------AELLRGKRVLVLVPRRElLEQW 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  578 VKEFHTWwppfrvavLHETGSYTHKKERlirdivyCHGVLITSYS--YIRLMQDDISRHdWHYVILDEGHKIRNPNAAVT 655
Cdd:COG1061    144 AEELRRF--------LGDPLAGGGKKDS-------DAPITVATYQslARRAHLDELGDR-FGLVIIDEAHHAGAPSYRRI 207

                          250
                   ....*....|....*...
gi 1767231856  656 LacKQFRTPHRIILSGSP 673
Cdd:COG1061    208 L--EAFPAAYRLGLTATP 223
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 894-951 1.34e-07

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 50.40  E-value: 1.34e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  894 ITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKK 951
Cdd:cd18785     13 IEHAEEIASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 503-713 1.93e-06

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 50.43  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  503 LFKYQQTGVRWLWElhcQQAGGILGDeMGLGKTIQIIAFLAGLsyskirtrgsnyRFEGL-GPTIIVCPTTVM-HQWVKE 580
Cdd:cd18013      1 PHPYQKVAINFIIE---HPYCGLFLD-MGLGKTVTTLTALSDL------------QLDDFtRRVLVIAPLRVArSTWPDE 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  581 FHTWWPPF--RVAVLHETGSYTHKKERLIRDIvychgvLITSYSYIRLMqDDISRHDWHY--VILDEGHKIRNPNAAVTL 656
Cdd:cd18013     65 VEKWNHLRnlTVSVAVGTERQRSKAANTPADL------YVINRENLKWL-VNKSGDPWPFdmVVIDELSSFKSPRSKRFK 137

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767231856  657 ACKQFR-TPHRII-LSGSPMQNNLRELWSLFDFIFPGK-LG-TLPVFMEQFSVPITMGGYS 713
Cdd:cd18013    138 ALRKVRpVIKRLIgLTGTPSPNGLMDLWAQIALLDQGErLGrSITAYRERWFDPDKRNGQQ 198
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 523-670 1.18e-05

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 46.63  E-value: 1.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  523 GGILGDEMGLGKTIqiIAFLAGLSYskIRTRGsnyrfeglGPTIIVCPT-TVMHQWVKEFHTWW-PPFRVAVLHETGSYT 600
Cdd:cd00046      3 NVLITAPTGSGKTL--AALLAALLL--LLKKG--------KKVLVLVPTkALALQTAERLRELFgPGIRVAVLVGGSSAE 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231856  601 HKKERLIRDIVychgVLITSYSYIR--LMQDD-ISRHDWHYVILDEGHKI----RNPNAAVTLACKQFRTPHRIILS 670
Cdd:cd00046     71 EREKNKLGDAD----IIIATPDMLLnlLLREDrLFLKDLKLIIVDEAHALlidsRGALILDLAVRKAGLKNAQVILL 143
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
 531-645 1.40e-03

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 41.13  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231856  531 GLGKTIQIIAflaglSYSKIRTRgsnyrfeglgpTIIVCPTTV-MHQWVKEFHTW--WPPFRVAVlhetgsYTHKKerli 607
Cdd:cd18029     36 GAGKTLVGIT-----AACTIKKS-----------TLVLCTSAVsVEQWRRQFLDWttIDDEQIGR------FTSDK---- 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1767231856  608 RDIVYCHGVLITSYSYIR----------LMQDDISRHDWHYVILDEGH 645
Cdd:cd18029     90 KEIFPEAGVTVSTYSMLAntrkrspeseKFMEFITEREWGLIILDEVH 137
46 PHA02562
endonuclease subunit; Provisional
 122-199 3.17e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 3.17e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231856  122 CVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAIL 199
Cdd:PHA02562   290 CTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAI 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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