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Conserved domains on  [gi|613390266|gb|EZZ94129|]
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sensor histidine kinase gRas [Staphylococcus aureus VET0057R]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
17-331 7.83e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.52  E-value: 7.83e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  17 WIFWILFLNILMLGISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKDKEIEEIKHKDLAETPFQRHTV 96
Cdd:COG0642    5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  97 DYLYRQILAHKDkvVDQQLQLKMHEQTITEFV----HDIKTPVTAMKLLID------QEENQERKQALLFEWSRINSMLD 166
Cdd:COG0642   85 LLLLLLLLLLLL--LALLLLLEEANEAKSRFLanvsHELRTPLTAIRGYLEllleelDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 167 TQLYITRLESQRKDMFFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVD-NHVYTDIKWCRMIIRQILSNALKYS-EN 244
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTpEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 245 YNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERgFTSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTV 324
Cdd:COG0642  243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEP-FFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....*..
gi 613390266 325 KLIFPLQ 331
Cdd:COG0642  322 TVTLPLA 328
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
17-331 7.83e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.52  E-value: 7.83e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  17 WIFWILFLNILMLGISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKDKEIEEIKHKDLAETPFQRHTV 96
Cdd:COG0642    5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  97 DYLYRQILAHKDkvVDQQLQLKMHEQTITEFV----HDIKTPVTAMKLLID------QEENQERKQALLFEWSRINSMLD 166
Cdd:COG0642   85 LLLLLLLLLLLL--LALLLLLEEANEAKSRFLanvsHELRTPLTAIRGYLEllleelDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 167 TQLYITRLESQRKDMFFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVD-NHVYTDIKWCRMIIRQILSNALKYS-EN 244
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTpEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 245 YNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERgFTSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTV 324
Cdd:COG0642  243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEP-FFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....*..
gi 613390266 325 KLIFPLQ 331
Cdd:COG0642  322 TVTLPLA 328
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-329 1.89e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 140.50  E-value: 1.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 222 TDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYL 300
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSkQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 613390266 301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 222-331 4.42e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.72  E-value: 4.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266   222 TDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYL 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 613390266   301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 222-332 7.26e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 80.88  E-value: 7.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  222 TDIKWCRMIIRQILSNALKYSENY-NVDISTELiDQHVALIIKDRGRGISKKDMPRIFERGftSTANRNETTSSGMGLYL 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAgEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPF--STADKRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 613390266  301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQN 332
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 122-330 9.05e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 77.96  E-value: 9.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 122 QTITefvHDIKTPVTAMK----LLIDQ--EENQER------KQALlfewsRINSMLDTQLYITRLESQRKDMFFDYVSLK 189
Cdd:PRK11100 261 QTLT---HELKSPLAAIRgaaeLLQEDppPEDRARftgnilTQSA-----RLQQLIDRLLELARLEQRQELEVLEPVALA 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 190 RMVID-----EIQLTRhisqvKGIGFDIDFkVDNHVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIK 263
Cdd:PRK11100 333 ALLEElvearEAQAAA-----KGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVE 406

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613390266 264 DRGRGISKKDMPRIFERgFTSTAnRNETT--SSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:PRK11100 407 DQGPGIPDYALPRIFER-FYSLP-RPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
17-331 7.83e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.52  E-value: 7.83e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  17 WIFWILFLNILMLGISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKDKEIEEIKHKDLAETPFQRHTV 96
Cdd:COG0642    5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  97 DYLYRQILAHKDkvVDQQLQLKMHEQTITEFV----HDIKTPVTAMKLLID------QEENQERKQALLFEWSRINSMLD 166
Cdd:COG0642   85 LLLLLLLLLLLL--LALLLLLEEANEAKSRFLanvsHELRTPLTAIRGYLEllleelDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 167 TQLYITRLESQRKDMFFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVD-NHVYTDIKWCRMIIRQILSNALKYS-EN 244
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTpEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 245 YNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERgFTSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTV 324
Cdd:COG0642  243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEP-FFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....*..
gi 613390266 325 KLIFPLQ 331
Cdd:COG0642  322 TVTLPLA 328
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-329 1.89e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 140.50  E-value: 1.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 222 TDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYL 300
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSkQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 613390266 301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
112-333 1.42e-39

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 140.04  E-value: 1.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 112 DQQLQLKMHEQTITEFV----HDIKTPVTAMK-----LLIDQEENQERKQALLF----EWSRINSMLDTQLYITRLESQR 178
Cdd:COG2205    4 EALEELEELERLKSEFLanvsHELRTPLTSILgaaelLLDEEDLSPEERRELLEiireSAERLLRLIEDLLDLSRLESGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 179 KDMFFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVDN-HVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQ 256
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSpPGGTITISARREGD 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613390266 257 HVALIIKDRGRGISKKDMPRIFERGFTSTANRNeTTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNE 333
Cdd:COG2205  164 GVRISVSDNGPGIPEEELERIFERFYRGDNSRG-EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
21-333 1.18e-34

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 130.83  E-value: 1.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  21 ILFLNILMLGISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKDKEIEEIKHKDLAETPFQRHTVDYLY 100
Cdd:COG5002   65 LLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 101 RQILAHKDKVVDQQLQLkmhEQTITEFV----HDIKTPVTAMKLLI---------DQEENQERKQALLFEWSRINSMLDT 167
Cdd:COG5002  145 LLLLAAVERDITELERL---EQMRREFVanvsHELRTPLTSIRGYLellldgaadDPEERREYLEIILEEAERLSRLVND 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 168 QLYITRLESQRKDMFFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVDN-HVYTDIKWCRMIIRQILSNALKYS-ENY 245
Cdd:COG5002  222 LLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPlLVLGDPDRLEQVLTNLLDNAIKYTpEGG 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 246 NVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTS-SGMGLYLVDSVKDQLGIQLQVTSTIGKGTTV 324
Cdd:COG5002  302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPGKGTTF 381


                 ....*....
gi 613390266 325 KLIFPLQNE 333
Cdd:COG5002  382 TITLPLARE 390
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 222-331 4.42e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.72  E-value: 4.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266   222 TDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYL 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 613390266   301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 222-332 7.26e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 80.88  E-value: 7.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  222 TDIKWCRMIIRQILSNALKYSENY-NVDISTELiDQHVALIIKDRGRGISKKDMPRIFERGftSTANRNETTSSGMGLYL 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAgEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPF--STADKRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 613390266  301 VDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQN 332
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 129-333 1.74e-18

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 85.78  E-value: 1.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMKLLID----------QEENQERKQAL---LFEWSRINSMLDTQLYITRLESQRKDMffdyVSLKRMVIDE 195
Cdd:COG5000  210 HEIKNPLTPIQLSAErlrrkladklEEDREDLERALdtiIRQVDRLKRIVDEFLDFARLPEPQLEP----VDLNELLREV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 196 IQLTRHISQVKGIGFDIDF-KVDNHVYTDikwcRMIIRQILSNALK-----YSENYNVDISTELIDQHVALIIKDRGRGI 269
Cdd:COG5000  286 LALYEPALKEKDIRLELDLdPDLPEVLAD----RDQLEQVLINLLKnaieaIEEGGEIEVSTRREDGRVRIEVSDNGPGI 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 270 SKKDMPRIFERGFTSTANrnettSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNE 333
Cdd:COG5000  362 PEEVLERIFEPFFTTKPK-----GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEE 420
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 122-330 9.05e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 77.96  E-value: 9.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 122 QTITefvHDIKTPVTAMK----LLIDQ--EENQER------KQALlfewsRINSMLDTQLYITRLESQRKDMFFDYVSLK 189
Cdd:PRK11100 261 QTLT---HELKSPLAAIRgaaeLLQEDppPEDRARftgnilTQSA-----RLQQLIDRLLELARLEQRQELEVLEPVALA 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 190 RMVID-----EIQLTRhisqvKGIGFDIDFkVDNHVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIK 263
Cdd:PRK11100 333 ALLEElvearEAQAAA-----KGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVE 406

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613390266 264 DRGRGISKKDMPRIFERgFTSTAnRNETT--SSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:PRK11100 407 DQGPGIPDYALPRIFER-FYSLP-RPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
115-336 4.66e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 76.16  E-value: 4.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 115 LQLKMHEQ----TITEFV----HDIKTPVTA----MKLLIDQEENQERKQAL---LFEWSRINSMLDTQLYITR-LESQr 178
Cdd:PRK11360 377 LQRRVARQerlaALGELVagvaHEIRNPLTAirgyVQIWRQQTSDPPSQEYLsvvLREVDRLNKVIDQLLEFSRpRESQ- 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 179 kdmfFDYVSLKRMVIDEIQLTRHISQVKGIGFDIDFKVD-NHVYTDIKWCRMIIRQILSNALK-YSENYNVDISTELI-D 255
Cdd:PRK11360 456 ----WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNElPPIWADPELLKQVLLNILINAVQaISARGKIRIRTWQYsD 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 256 QHVALIIKDRGRGISKKDMPRIFERGFTSTAnrnetTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNEIV 335
Cdd:PRK11360 532 GQVAVSIEDNGCGIDPELLKKIFDPFFTTKA-----KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606


                 .
gi 613390266 336 E 336
Cdd:PRK11360 607 Q 607
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 129-331 6.91e-14

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 71.75  E-value: 6.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTA-------MKLLIDQEENQERKQALLfewSRINSMLD--TQLyITRLE--SQRKDMFFDYVSLKRMVIDEIQ 197
Cdd:COG4191  151 HEINNPLAAilgnaelLRRRLEDEPDPEELREAL---ERILEGAEraAEI-VRSLRafSRRDEEEREPVDLNELIDEALE 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 198 LTRHisQVKGIGFDIDFKVDNH---VYTDikwcRMIIRQILSN-------ALKYSENYNVDISTELIDQHVALIIKDRGR 267
Cdd:COG4191  227 LLRP--RLKARGIEVELDLPPDlppVLGD----PGQLEQVLLNllinaidAMEEGEGGRITISTRREGDYVVISVRDNGP 300

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 268 GISKKDMPRIFERGFTStanRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:COG4191  301 GIPPEVLERIFEPFFTT---KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 231-330 4.81e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 64.82  E-value: 4.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 231 IRQIL----SNALKYSENYNVDISTELI---DQHVALI--IKDRGRGISKKDMPRIFERgFT----STANRNETTssGMG 297
Cdd:cd16922    1 LRQILlnllGNAIKFTEEGEVTLRVSLEeeeEDGVQLRfsVEDTGIGIPEEQQARLFEP-FSqadsSTTRKYGGT--GLG 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 613390266 298 LYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:cd16922   78 LAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 129-333 6.84e-13

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 69.11  E-value: 6.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMKLLIDQEENQERKQallfewsrinsmldtqlYITRLESQRKDMF-FDYVSLKRMVIDEIqLTRHISQV-- 205
Cdd:COG3290  198 HDFRNHLHTISGLLQLGEYDEALE-----------------YIDEISEELQELIdSLLSRIGNPVLAAL-LLGKAARAre 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 206 KGIGFDIDFKVDNHVYT--DIKWCRmIIRQILSNALKYSENYN-----VDISTELIDQHVALIIKDRGRGISKKDMPRIF 278
Cdd:COG3290  260 RGIDLTIDIDSDLPDLPlsDTDLVT-ILGNLLDNAIEAVEKLPeeerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIF 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 613390266 279 ERGFTSTANRNettsSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNE 333
Cdd:COG3290  339 ERGFSTKLGEG----RGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 129-331 9.45e-13

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 68.99  E-value: 9.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMK-----LLIDQEENQERKQALLFEWSRINSMLDTQLYITRLESQRKDMffdyVSLKRMVIDEIQLTRHIS 203
Cdd:COG5805  296 HEIRNPLTSIKgflqlLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEK----ENINELIQDVVTLLETEA 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 204 QVKGIGFDIDFK-VDNHVYTDIKWCRMIIRQILSNALKYSENY-NVDISTELIDQHVALIIKDRGRGISKKDMPRIFERG 281
Cdd:COG5805  372 ILHNIQIRLELLdEDPFIYCDENQIKQVFINLIKNAIEAMPNGgTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPF 451

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 613390266 282 FTstanrneTTSSGMGLYLVDSVK--DQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:COG5805  452 FT-------TKEKGTGLGLMVSYKiiENHNGTIDIDSKVGKGTTFTITLPLS 496
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
122-341 7.66e-12

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 66.68  E-value: 7.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  122 QTITEFVHDIKTPVTAMKLLID-----QEENQERKQALLFEWSRINSMLD---TQLYITRLESQRKDMFFDYVSLKRMVI 193
Cdd:PRK09959  714 QFLATMSHEIRTPISSIMGFLEllsgsGLSKEQRVEAISLAYATGQSLLGligEILDVDKIESGNYQLQPQWVDIPTLVQ 793

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  194 DEIQLTRHISQVKGIGFDIDFKVDNH--VYTDIKWCRMIIRQILSNALKYSENYNVDISTELI---DQH--VALIIKDRG 266
Cdd:PRK09959  794 NTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGhidDNHavIKMTIMDSG 873

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613390266  267 RGISKKDMPRIFERGFTSTANRNEtTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLqnEIVERMSEV 341
Cdd:PRK09959  874 SGLSQEEQQQLFKRYSQTSAGRQQ-TGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV--EISQQVATV 945
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 16-333 9.90e-12

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 65.96  E-value: 9.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  16 NWIFWILFLNILMLGISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKDKEIEEIKHKDLAETPFQRHT 95
Cdd:COG4251  174 ALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLE 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  96 VDYLYRQILAHKDKVVDQQLQLKMHEQTITEFV----HDIKTPVTAMKLLID--QEENQERKQALLFEW--------SRI 161
Cdd:COG4251  254 LLELRLELEELEEELEERTAELERSNEELEQFAyvasHDLREPLRKISGFSQllEEDYGDKLDEEGREYlerirdaaERM 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 162 NSMLDTQLYITRLEsqRKDMFFDYVSLKRmVIDEIqLTRHISQVKGIGFDIDFKVDNHVYTDIKWCRMIIRQILSNALKY 241
Cdd:COG4251  334 QALIDDLLAYSRVG--RQELEFEPVDLNE-LLEEV-LEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKY 409

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 242 S---ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERgFTSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTI 318
Cdd:COG4251  410 SrpgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEI-FQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEP 488

                        330
                 ....*....|....*
gi 613390266 319 GKGTTVKLIFPLQNE 333
Cdd:COG4251  489 GEGATFYFTLPKAPA 503
PRK15347 PRK15347
two component system sensor kinase;
124-331 2.56e-11

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 65.05  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 124 ITEFVHDIKTP----VTAMKLLIDQEENQerKQALLFEWSR---------INSMLDtqlyITRLESQRKDMFFDYVSLKR 190
Cdd:PRK15347 402 LTTISHEIRTPlngvLGALELLQNTPLTA--EQMDLADTARqctlsllaiINNLLD----FSRIESGQMTLSLEETALLP 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 191 MvIDEIQLTRHiSQVKGIGFDIDFKVDNHV----YTDikwcRMIIRQIL----SNALKYSENYNVDISTELIDQHVALII 262
Cdd:PRK15347 476 L-LDQAMLTIQ-GPAQSKSLTLRTFVGAHVplylHLD----SLRLRQILvnllGNAVKFTETGGIRLRVKRHEQQLCFTV 549

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613390266 263 KDRGRGISKKDMPRIFERGFTSTANRNETtssGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:PRK15347 550 EDTGCGIDIQQQQQIFTPFYQADTHSQGT---GLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-330 3.51e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 56.66  E-value: 3.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 228 RMIIRQILSNAL-----KYSENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTStanRNETTSSGMGLYLVD 302
Cdd:cd16943    1 PSQLNQVLLNLLvnaaqAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTT---KPVGEGTGLGLSLSY 77

                         90       100
                 ....*....|....*....|....*...
gi 613390266 303 SVKDQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:cd16943   78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-329 4.01e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 56.44  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 228 RMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTS-SGMGLYLVDSVK 305
Cdd:cd16952    2 RSAFSNLVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVM 81

                         90       100
                 ....*....|....*....|....
gi 613390266 306 DQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16952   82 SRHDARLLIASELGKGSRFTCLFP 105
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
204-333 1.23e-09

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 58.09  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 204 QVKGIGFDIDFKVDNHVYtdikwcrMIIRQILSNALKYSENYNVDISTELIDQHVALIIKDRGRGIskkdmprifergft 283
Cdd:COG4585  147 DVDGDPDRLPPEVELALY-------RIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGF-------------- 205

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 613390266 284 staNRNETTSSGMGLylvDSVKD---QLGIQLQVTSTIGKGTTVKLIFPLQNE 333
Cdd:COG4585  206 ---DPEAAPGGGLGL---RGMREraeALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-329 2.21e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 54.22  E-value: 2.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 230 IIRQILSNALKY---SENYNVDISTELIDQHVALIIK--DRGRGISKKDMPRIFERGFTSTANRNEttssGMGLYLVDSV 304
Cdd:cd16915    4 IVGNLIDNALDAlaaTGAPNKQVEVFLRDEGDDLVIEvrDTGPGIAPELRDKVFERGVSTKGQGER----GIGLALVRQS 79

                         90       100
                 ....*....|....*....|....*
gi 613390266 305 KDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16915   80 VERLGGSITVESEPGGGTTFSIRIP 104
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 129-330 2.95e-09

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 58.06  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMK----LLIDQEENQERK--QALLFEWSRINSMLDTQLYITRlesqRKDMFFDYVSLKRMVIDEIQLTrhi 202
Cdd:COG5809  279 HEIRNPLTSLKgfiqLLKDTIDEEQKTylDIMLSELDRIESIISEFLVLAK----PQAIKYEPKDLNTLIEEVIPLL--- 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 203 sQVKGIGFDIDFKVDNHVYTDIKWC-----RMIIRQILSNALKY-SENYNVDISTELIDQHVALI-IKDRGRGISKKDMP 275
Cdd:COG5809  352 -QPQALLKNVQIELELEDDIPDILGdenqlKQVFINLLKNAIEAmPEGGNITIETKAEDDDKVVIsVTDEGCGIPEERLK 430

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613390266 276 RIFERGFTstanrneTTSSGMGLYLVDSVK--DQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:COG5809  431 KLGEPFYT-------TKEKGTGLGLMVSYKiiEEHGGKITVESEVGKGTTFSITLPI 480
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-326 3.53e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 53.62  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 230 IIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVDSVKDQL 308
Cdd:cd16975    8 ALINIISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKH 87

                         90
                 ....*....|....*...
gi 613390266 309 GIQLQVTSTIGKGTTVKL 326
Cdd:cd16975   88 GGSLIIENSQKGGAEVTV 105
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 217-326 4.39e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 53.56  E-value: 4.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 217 DNHVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDqHVALIIKDRGRGISKKDMPRIFERgFTSTANRNeTTSSG 295
Cdd:cd16940    4 DIQVQGDALLLFLLLRNLVDNAVRYSpQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFER-FYRSDGQN-YGGSG 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 613390266 296 MGLYLVDSVKDQLGIQLQVTSTIGKGTTVKL 326
Cdd:cd16940   81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 226-314 9.64e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 52.46  E-value: 9.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 226 WCRMIIRQILSNALKYSENYN-VDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVDSV 304
Cdd:cd16945    4 LLRQAINNLLDNAIDFSPEGGlIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQEV 83

                         90
                 ....*....|
gi 613390266 305 KDQLGIQLQV 314
Cdd:cd16945   84 AQLHGGRITL 93
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 228-331 1.25e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 56.45  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 228 RMIIRQILSNALKYSENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETtssGMGLYLVDSVKDQ 307
Cdd:PRK11466 563 RQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGT---GLGLTISSRLAQA 639

                         90       100
                 ....*....|....*....|....
gi 613390266 308 LGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:PRK11466 640 MGGELSATSTPEVGSCFCLRLPLR 663
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
129-329 1.36e-08

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 55.79  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMK----LLIDQE-ENQERKQALLF---EWSRINSMLDTQLYITRLESQRKDMFFDYVSLKRMvideIQLTR 200
Cdd:PRK11006 213 HELRTPLTVLQgyleMMQDQPlEGALREKALHTmreQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMM----LRVLE 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 201 HISQVKGIG-FDIDFKVDNH--VYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPR 276
Cdd:PRK11006 289 REAQTLSQGkHTITFEVDNSlkVFGNEDQLRSAISNLVYNAVNHTpEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPR 368

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 613390266 277 IFERGF-TSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:PRK11006 369 LTERFYrVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-326 1.38e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.52  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 230 IIRQILSNALKY-SENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNET-TSSGMGLYLVDSVKDQ 307
Cdd:cd16947   24 ILKNLISNAIKYgSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkQGNGLGLTITKRLAES 103

                         90       100
                 ....*....|....*....|.
gi 613390266 308 LGIQLQVTSTIGKGT--TVKL 326
Cdd:cd16947  104 MGGSIYVNSKPYEKTvfTVTL 124
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 256-329 1.51e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 52.38  E-value: 1.51e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 256 QHVALIIKDRGRGISKKDMPRIFERGFTStanRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16919   46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTT---KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
112-333 8.64e-08

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 53.31  E-value: 8.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 112 DQQLQLKMHEQTITEFV----HDIKTPVTAMK----LL---IDQEENQERKQALLFEWSRINSMLDtqlyitRLE--SQR 178
Cdd:COG3852  123 ERELRRAEKLAAVGELAaglaHEIRNPLTGIRgaaqLLereLPDDELREYTQLIIEEADRLNNLVD------RLLsfSRP 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 179 KDMFFDYVSLKRmVIDEIqltRHISQV---KGIGFDIDFKVDN-HVYTDikwcRMIIRQ----ILSNA-----------L 239
Cdd:COG3852  197 RPPEREPVNLHE-VLERV---LELLRAeapKNIRIVRDYDPSLpEVLGD----PDQLIQvllnLVRNAaeampeggtitI 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 240 KYSENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANrnettSSGMGLYLVDSVKDQLGIQLQVTSTIG 319
Cdd:COG3852  269 RTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK-----GTGLGLAIVQKIVEQHGGTIEVESEPG 343

                        250
                 ....*....|....
gi 613390266 320 KGTTVKLIFPLQNE 333
Cdd:COG3852  344 KGTTFRIYLPLEQA 357
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
258-333 1.55e-07

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 52.87  E-value: 1.55e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613390266 258 VALIIKDRGRGISKKDMPRIFERGFTStanRNETTssGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNE 333
Cdd:PRK10364 381 VKISVTDSGKGIAADQLEAIFTPYFTT---KAEGT--GLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 238-333 1.62e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 52.61  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 238 ALKYSENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGF-TSTANRnettssGMGLYLVDSVKDQLGIQLQVTS 316
Cdd:PRK11086 448 AVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYsTKGSNR------GVGLYLVKQSVENLGGSIAVES 521

                         90
                 ....*....|....*..
gi 613390266 317 TIGKGTTVKLIFPLQNE 333
Cdd:PRK11086 522 EPGVGTQFFVQIPWDGE 538
PRK13560 PRK13560
hypothetical protein; Provisional
 109-330 1.82e-07

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 52.75  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 109 KVVDQQLQLKMHEQTI--TEFVHDIKTPVTAMKLLID-QEE---NQERKQALLFEWSRINSM--LDTQLYitrlesQRKD 180
Cdd:PRK13560 592 KHAEEKIKAALTEKEVllKEIHHRVKNNLQIISSLLDlQAEklhDEEAKCAFAESQDRICAMalAHEKLY------QSED 665

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 181 M----FFDYVSlkrmvideiQLTRHISQVKGIGFD-IDFKVD-NHVYTDIKW---CRMIIRQILSNALKYS------ENY 245
Cdd:PRK13560 666 LadidFLDYIE---------SLTAHLKNSFAIDFGrIDCKIDaDDGCLDIDKaipCGLIISELLSNALKHAfpdgaaGNI 736

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 246 NVDIsTELIDQHVALIIKDRGRGISkkdmprifergftstANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTigKGTTVK 325
Cdd:PRK13560 737 KVEI-REQGDGMVNLCVADDGIGLP---------------AGFDFRAAETLGLQLVCALVKQLDGEIALDSR--GGARFN 798


                 ....*
gi 613390266 326 LIFPL 330
Cdd:PRK13560 799 IRFPM 803
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
227-330 2.79e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 48.76  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 227 CRMIIRQILSNALKYSENYN----VDISTELIDQHVALIIKDRGRGISKKDMPRIFErgftstanrnETTSSGMGLYLVD 302
Cdd:COG2172   35 LVLAVSEAVTNAVRHAYGGDpdgpVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS----------TLAEGGRGLFLIR 104

                         90       100
                 ....*....|....*....|....*...
gi 613390266 303 SVKDQLGIQlqvtsTIGKGTTVKLIFPL 330
Cdd:COG2172  105 RLMDEVEYE-----SDPGGTTVRLVKRL 127
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-328 3.26e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 48.78  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 234 ILSNALKYSENYnVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGftstaNRNETTSSGMGLYL--VDSVKDQLGIQ 311
Cdd:cd16954   45 LLDNACKWCLEF-VEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRG-----QRLDEQRPGQGLGLaiAKEIVEQYGGE 118

                         90
                 ....*....|....*..
gi 613390266 312 LQVTSTIGKGTTVKLIF 328
Cdd:cd16954  119 LSLSDSPLGGARFEVVF 135
PRK13557 PRK13557
histidine kinase; Provisional
 257-343 7.99e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 50.44  E-value: 7.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 257 HVALIIKDRGRGISKKDMPRIFERGFTStanRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQNEIVE 336
Cdd:PRK13557 324 YVSIAVTDTGSGMPPEILARVMDPFFTT---KEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAEN 400


                 ....*..
gi 613390266 337 RMSEVTN 343
Cdd:PRK13557 401 PEQEPKA 407
PRK09303 PRK09303
histidine kinase;
116-321 1.14e-06

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 49.95  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 116 QLKMHEQTITEFVHDIKTPVTAMKLLID------QEENQERKQAL---LFEWSR-----INSM----------LDTQLyi 171
Cdd:PRK09303 147 QLKFKDRVLAMLAHDLRTPLTAASLALEtlelgqIDEDTELKPALieqLQDQARrqleeIERLitdllevgrtRWEAL-- 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 172 tRLESQRkdmfFDYVSLKRMVIDEIQLtrhISQVKGIGFDIDFKVD-NHVYTDIKWCRMIIRQILSNALKYSENYNvDIS 250
Cdd:PRK09303 225 -RFNPQK----LDLGSLCQEVILELEK---RWLAKSLEIQTDIPSDlPSVYADQERIRQVLLNLLDNAIKYTPEGG-TIT 295

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613390266 251 TELID---QHVALIIKDRGRGISKKDMPRIFERGFtsTANRNETTSS-GMGLYLVDSVKDQLGIQLQVTSTIGKG 321
Cdd:PRK09303 296 LSMLHrttQKVQVSICDTGPGIPEEEQERIFEDRV--RLPRDEGTEGyGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
129-316 1.48e-06

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 49.77  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAmklLIDQEE---NQERKQ--------ALLFEWSRINSMLDTQLYITRLESQR----KDMFfdyvSLKRMVI 193
Cdd:PRK09835 271 HEIRTPITN---LITQTEialSQSRSQkeledvlySNLEELTRMAKMVSDMLFLAQADNNQlipeKKML----DLADEVG 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 194 DEIQLTRHISQVKGIGFDIDFKvDNHVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKK 272
Cdd:PRK09835 344 KVFDFFEAWAEERGVELRFVGD-PCQVAGDPLMLRRAISNLLSNALRYTpAGEAITVRCQEVDHQVQLVVENPGTPIAPE 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 613390266 273 DMPRIFERGFTSTANRNET-TSSGMGLYLVDSVKDQLGIQLQVTS 316
Cdd:PRK09835 423 HLPRLFDRFYRVDPSRQRKgEGSGIGLAIVKSIVVAHKGTVAVTS 467
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 222-327 2.00e-06

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 46.76  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 222 TDIKwcrMIIRQILSNAL--KYSENYN--VDISTELIDQHVALIIKDRGRGIskKDMPRIFERGFTStanRNETTSSGMG 297
Cdd:cd16942   37 TEIK---TVVSEAVTNAIihGYNNDPNgiVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTT---KPELERSGMG 108

                         90       100       110
                 ....*....|....*....|....*....|
gi 613390266 298 LYLVDSVKDQLgiqlQVTSTIGKGTTVKLI 327
Cdd:cd16942  109 FTIMENFMDEV----IVESEVNKGTTVYLK 134
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 229-332 2.13e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.13  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 229 MIIRQILSNALKY----SENYNVDISTELIDQHVALIIKDRGRGISkkdmprifergftstANRNETTSSGMGLYLVDSV 304
Cdd:COG3920  402 LILNELVTNALKHaflsGEGGRIRVSWRREDGRLRLTVSDNGVGLP---------------EDVDPPARKGLGLRLIRAL 466

                         90       100
                 ....*....|....*....|....*...
gi 613390266 305 KDQLGIQLQVTStiGKGTTVKLIFPLQN 332
Cdd:COG3920  467 VRQLGGTLELDR--PEGTRVRITFPLAE 492
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-329 2.87e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 45.13  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 231 IRQILSN----ALKYSeNYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFeRGFTSTANRNETTSSGMGLYLVDSVKD 306
Cdd:cd16950    1 LKRVLSNlvdnALRYG-GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELF-QPFYRGDNARGTSGTGLGLAIVQRISD 78

                         90       100
                 ....*....|....*....|...
gi 613390266 307 QLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16950   79 AHGGSLTLANRAGGGLCARIELP 101
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
192-298 4.36e-06

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 48.09  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 192 VIDEIQLT----RHISQVKGIGFDIDFKVDNHVYTDIKWCRMIIRQILSNALKYS-ENYNVDISTELIDQHVALIIKDRG 266
Cdd:PRK10549 314 LVPLLEVAggafRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTdSGGSLHISAEQRDKTLRLTFADSA 393

                         90       100       110
                 ....*....|....*....|....*....|...
gi 613390266 267 RGISKKDMPRIFERGFTSTANRNETT-SSGMGL 298
Cdd:PRK10549 394 PGVSDEQLQKLFERFYRTEGSRNRASgGSGLGL 426
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-330 5.17e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 44.62  E-value: 5.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 231 IRQILSNALKYS-ENYNVDISTEliDQHVALIIKDRGRGISKKDMPRIFeRGF--TSTANRNETTSSGMGLYLVDSVKDQ 307
Cdd:cd16949    5 LENVLRNALRYSpSKILLDISQD--GDQWTITITDDGPGVPEDQLEQIF-LPFyrVDSARDRESGGTGLGLAIAERAIEQ 81

                         90       100
                 ....*....|....*....|...
gi 613390266 308 LGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:cd16949   82 HGGKIKASNRKPGGLRVRIWLPA 104
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-298 6.12e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 44.76  E-value: 6.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613390266 228 RMIIRQILSNALKYSE-NYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETT-SSGMGL 298
Cdd:cd16946    6 QQLFVNLLENSLRYTDtGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASgGSGLGL 78
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-329 1.23e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 43.53  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 234 ILSNALKYS-ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRNeTTSSGMGLYLVDSVKDQLGIQL 312
Cdd:cd16923    8 LLSNAIKYSpENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN-TEGAGLGLSIAKAIIELHGGSA 86

                         90
                 ....*....|....*..
gi 613390266 313 QVTSTiGKGTTVKLIFP 329
Cdd:cd16923   87 SAEYD-DNHDLFKVRLP 102
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
258-331 1.37e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 46.98  E-value: 1.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 258 VALIIKDRGRGISKKDMPRIFERGFTSTANRNettssGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKLIFPLQ 331
Cdd:PRK13837 608 VLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGT-----GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPS 676
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-329 2.83e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 42.16  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 229 MIIRQILSNALKYSENYNVDISTELIDQHVALIIKDRGRGISKKDMPRifergftstanrnettSSGMGLYlvdSVK--- 305
Cdd:cd16917    3 RIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG----------------GGGFGLL---GMRera 63

                         90       100
                 ....*....|....*....|....
gi 613390266 306 DQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16917   64 ELLGGTLTIGSRPGGGTRVTARLP 87
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 190-331 4.60e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 45.23  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 190 RMVIDE-IQLTRHISQVKGIGF--DIDFKVDNHVYTDikwcRMIIRQIL----SNALKYSENYNVDISTELI---DQHVA 259
Cdd:PRK11107 369 RETLDEvVTLLAHSAHEKGLELtlNIDPDVPDNVIGD----PLRLQQIItnlvGNAIKFTESGNIDILVELRalsNTKVQ 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 260 L--IIKDRGRGISKKDMPRIFergftsTANRNETTS-----SGMGLYLVDSVK--DQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:PRK11107 445 LevQIRDTGIGISERQQSQLF------QAFRQADASisrrhGGTGLGLVITQKlvNEMGGDISFHSQPNRGSTFWFHLPL 518


                 .
gi 613390266 331 Q 331
Cdd:PRK11107 519 D 519
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
31-333 4.63e-05

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.01  E-value: 4.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266  31 ISLIDYDFPIDSLFYIVSLNLSLTLIFLILTFFKEVKLYRHFEKD-----KEIEEIKHKDLAETPFQRHT-VDYLYRQIL 104
Cdd:COG2972  140 VSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPikrlkKAMKKVEKGDLVRLEVSGNDeIGILARSFN 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 105 AHKDKVVDQQLQLKMHEQTITE----------FVHDIKTPVTAMKLLIDQEENQERKQALLfewsRINSMLDTQLYITRl 174
Cdd:COG2972  220 EMVERIKELIEEVYELELEKKEaelkalqaqiNPHFLFNTLNSIRWLAELEDPEEAEEMLE----ALSKLLRYSLSKGD- 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 175 esqrkdmffDYVSLKrmviDEIQLTRHISQVKGI----GFDIDFKVDNHVYtDIKWCRMIIRQILSNALKYS-----ENY 245
Cdd:COG2972  295 ---------ELVTLE----EELELIKSYLEIQKLrfgdRLEVEIEIDEELL-DLLIPKLILQPLVENAIEHGiepkeGGG 360

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 246 NVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTSTANRnettssGMGLYlvdSVKDQL------GIQLQVTSTIG 319
Cdd:COG2972  361 TIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLR---NVRERLklyygeEYGLEIESEPG 431

                        330
                 ....*....|....
gi 613390266 320 KGTTVKLIFPLQNE 333
Cdd:COG2972  432 EGTTVTIRIPLEEE 445
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
234-332 8.15e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 44.24  E-value: 8.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 234 ILSNALKYSENYnVDISTELIDQHVALIIKDRGRGI--SKKDMprIFERGftstaNRNETTSSGMGLYLvdSVKDQLGIQ 311
Cdd:PRK10815 386 VLDNACKYCLEF-VEISARQTDEHLHIVVEDDGPGIpeSKREL--IFDRG-----QRADTLRPGQGLGL--SVAREITEQ 455

                         90       100
                 ....*....|....*....|....*
gi 613390266 312 LQVTSTIGK----GTTVKLIFPLQN 332
Cdd:PRK10815 456 YEGKISAGDsplgGARMEVIFGRQH 480
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
129-307 1.19e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 43.77  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMKL---LIdqeenqERKQALLFEWSRInsmlDTQlyITRLESqrkdMFFDYVSLKRMVIDEiQLTRHISQV 205
Cdd:PRK09470 252 HELRTPLTRLQLataLL------RRRQGESKELERI----ETE--AQRLDS----MINDLLVLSRNQQKN-HLERETFKA 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 206 KGIGFDI-------------DFKVDNH-----VYTDIKWCRMIIRQILSNALKYSeNYNVDISTELIDQHVALIIKDRGR 267
Cdd:PRK09470 315 NSLWSEVledakfeaeqmgkSLTVSAPpgpwpINGNPNALASALENIVRNALRYS-HTKIEVAFSVDKDGLTITVDDDGP 393

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 613390266 268 GISKKDMPRIFeRGF--TSTANRNETTSSGMGLYLVDSVKDQ 307
Cdd:PRK09470 394 GVPEEEREQIF-RPFyrVDEARDRESGGTGLGLAIVENAIQQ 434
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-298 2.95e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 39.86  E-value: 2.95e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613390266 230 IIRQILSNALKYSENYNVDISTELID--QHVALIIKDRGRGISKKDMPRIFERGFTS-TANRNETTSSGMGL 298
Cdd:cd16953    4 VLRNLIGNAISFSPPDTGRITVSAMPtgKMVTISVEDEGPGIPQEKLESIFDRFYTErPANEAFGQHSGLGL 75
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 201-329 4.19e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 39.71  E-value: 4.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 201 HISQVKGIGFDI---DFKVDNHVYTDIKwcrMIIRQILSNALKYS----ENYNVDISTELIDQHVALIIKDRGRGiskkd 273
Cdd:cd16951   14 AIHAVGDIRINItgdTGPVSSEVATAIG---LVVNELLQNALKHAfsdrEGGTITIRSVVDGDYLRITVIDDGVG----- 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613390266 274 mpriFERGFTSTanrnetTSSGMGLYLVDS-VKDQLGIQLQVTSTiGKGTTVKLIFP 329
Cdd:cd16951   86 ----LPQDEDWP------NKGSLGLQIVRSlVEGELKAFLEVQSA-ENGTRVNIDIP 131
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
257-330 4.31e-04

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 42.09  E-value: 4.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 257 HVALIIKDRGRGISK------------------KDMPR------IFERGFtSTAnrnETTSS----GMGLylvDSVK--- 305
Cdd:COG0643  321 RVVIEVSDDGRGLDLekirakaiekglitaeeaAALSDeellelIFAPGF-STA---EEVTDlsgrGVGM---DVVKtni 393

                         90       100
                 ....*....|....*....|....*
gi 613390266 306 DQLGIQLQVTSTIGKGTTVKLIFPL 330
Cdd:COG0643  394 EALGGTIEIESEPGKGTTFTLRLPL 418
PRK10337 PRK10337
sensor protein QseC; Provisional
 129-326 5.09e-04

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 41.56  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 129 HDIKTPVTAMKLLID-----QEENQERKQALLFEWS---RINSMLDTQLYITRLES--QRKDMffDYVSLKRMVIDEIQL 198
Cdd:PRK10337 246 HELRSPLAALKVQTEvaqlsDDDPQARKKALLQLHAgidRATRLVDQLLTLSRLDSldNLQDV--AEIPLEDLLQSAVMD 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 199 TRHISQVKGIgfDIDFKVDNHvytdiKWCR--------MIIRQILSNALKYS-ENYNVDIStelIDQHvALIIKDRGRGI 269
Cdd:PRK10337 324 IYHTAQQAGI--DVRLTLNAH-----PVIRtgqplllsLLVRNLLDNAIRYSpQGSVVDVT---LNAR-NFTVRDNGPGV 392

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613390266 270 SKKDMPRIFERGFTSTAnrNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGTTVKL 326
Cdd:PRK10337 393 TPEALARIGERFYRPPG--QEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-329 6.14e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 38.85  E-value: 6.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 228 RMIIRQILSNALKYS---ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERgFTSTANRNETTSSGMGLYLVDSV 304
Cdd:cd16921    2 GQVLTNLLGNAIKFRrprRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGI-FQRLHSREEYEGTGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|....*
gi 613390266 305 KDQLGIQLQVTSTIGKGTTVKLIFP 329
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 230-298 7.97e-04

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 40.02  E-value: 7.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 230 IIRQILSNALKYSENY----NVDISTELID-QHVALIIKDRGRGISKKDMPRIFERGFTSTANRNETTSSGMGL 298
Cdd:cd16933   23 TVRELVENSLDATEEAgilpDIKVEIEEIGkDHYKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSRGQQGL 96
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 247-329 8.34e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 38.20  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 247 VDISTELIDQHVALIIKDRGRGISKKdmprifergFTSTANRNETTSSGMGLYLVDS-VKDQLG--IQLQVTSTIGKGTT 323
Cdd:cd16924   27 VTISALKEDNHVMIEVEDNGRGIDPK---------VLNILGKKPKEGNGIGLYNVHQrLILLFGedYGIHIASEPDKGTR 97


                 ....*.
gi 613390266 324 VKLIFP 329
Cdd:cd16924   98 ITFTIP 103
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-329 9.24e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 38.18  E-value: 9.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 233 QIL-SNALKYS-----ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTStanrnettSSGMGLYLVDSVKD 306
Cdd:cd16957    7 QVLvENAIRHAfpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTS--------EKGTGTALENLNRR 78

                         90       100
                 ....*....|....*....|....*...
gi 613390266 307 QLGI-----QLQVTSTIGKGTTVKLIFP 329
Cdd:cd16957   79 LIGLfgseaCLHIESEVHGGTEVWFVIP 106
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-321 1.36e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 37.82  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 234 ILSNALKYS---ENYNVDISTELIDQHVALIIKDRGRGISKKDMPRIFERGFTStanRNETTSSGMGLYLVDSVKDQLGI 310
Cdd:cd16976    8 LLQNALDAMgkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT---KPVGKGTGLGLSISYGIVEEHGG 84

                         90
                 ....*....|.
gi 613390266 311 QLQVTSTIGKG 321
Cdd:cd16976   85 RLSVANEEGAG 95
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 277-339 1.68e-03

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 40.10  E-value: 1.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613390266 277 IFERGFtSTANRnETTSSGMGLYLvDSVK---DQLGIQLQVTSTIGKGTTVKLIFPLQNEIVERMS 339
Cdd:PRK10547 470 IFAPGF-STAEQ-VTDVSGRGVGM-DVVKrniQEMGGHVEIQSKQGKGTTIRILLPLTLAILDGMS 532
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
230-270 2.09e-03

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 40.04  E-value: 2.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 613390266 230 IIRQILSNALKYSENYNVDISTELIDQHVALIIKDRGRGIS 270
Cdd:PRK10600 473 IAREALSNALKHAQASEVVVTVAQNQNQVKLSVQDNGCGVP 513
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 198-344 6.06e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 38.38  E-value: 6.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613390266 198 LTRHISQVKGIGFDIDFK--VDNHVYTDIKWCRMIIRQILSNALKYSENYNVDISTE-LIDQHVALIIKDRGRGISKKDM 274
Cdd:PRK11091 368 LSGLQAEQKGLRFDLEPLlpLPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRyEEGDMLTFEVEDSGIGIPEDEL 447

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613390266 275 PRIFERGF--TSTANRNETTSSGMGLYLVDSVKDQLGIQLQVTSTIGKGT--TVKLIFPLQNEIVERMSEVTNL 344
Cdd:PRK11091 448 DKIFAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGScfTLTIHAPAVAEEVEDAFDEDDM 521
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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