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Conserved domains on  [gi|613388928|gb|EZZ92811|]
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hypothetical protein W395_01497 [Staphylococcus aureus VET0057R]

Protein Classification

FeoA family protein( domain architecture ID 10512799)

FeoA family protein similar to ferrous iron transport protein A (FeoA), which is part of the Feo (ferrous iron-transport) system that functions in the uptake of ferrous iron

Gene Ontology:  GO:0046914|GO:0006811
PubMed:  26684538|8407793|35012344|20516589
TCDB:  9.A.8.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 3-74 2.40e-13

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


:

Pssm-ID: 461133  Cd Length: 74  Bit Score: 58.37  E-value: 2.40e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613388928   3 NIKNGEmnkAYKIKRMDIANENMLYRLSAFGLTDDAIITIKQKCLFKGPCIIEVNGQQLSIRHCDACSIALE 74
Cdd:pfam04023  5 ELKEGE---TARIVRIRDGDPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
 
Name Accession Description Interval E-value
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 3-74 2.40e-13

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 58.37  E-value: 2.40e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613388928   3 NIKNGEmnkAYKIKRMDIANENMLYRLSAFGLTDDAIITIKQKCLFKGPCIIEVNGQQLSIRHCDACSIALE 74
Cdd:pfam04023  5 ELKEGE---TARIVRIRDGDPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
10-75 1.05e-12

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 56.68  E-value: 1.05e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613388928 10 NKAYKIKRMDiANENMLYRLSAFGLTDDAIITIKQKCLFKGPCIIEVNGQQLSIRHCDACSIALEE 75
Cdd:COG1918   9 GEKARIVRIS-GDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 10-75 3.52e-10

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 50.26  E-value: 3.52e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613388928   10 NKAYKIKRMDIANENMLYRLSAFGLTDDAIITIKQKCLFkGPCIIEVNGqQLSIRHCDACSIALEE 75
Cdd:smart00899  9 GEKARIVRIRDEDPELLRRLLELGLVPGTEVTVLRKAPF-GPLVVRVGG-ELALRREEAEKIFVEP 72
 
Name Accession Description Interval E-value
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 3-74 2.40e-13

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 58.37  E-value: 2.40e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613388928   3 NIKNGEmnkAYKIKRMDIANENMLYRLSAFGLTDDAIITIKQKCLFKGPCIIEVNGQQLSIRHCDACSIALE 74
Cdd:pfam04023  5 ELKEGE---TARIVRIRDGDPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
10-75 1.05e-12

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 56.68  E-value: 1.05e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613388928 10 NKAYKIKRMDiANENMLYRLSAFGLTDDAIITIKQKCLFKGPCIIEVNGQQLSIRHCDACSIALEE 75
Cdd:COG1918   9 GEKARIVRIS-GDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 10-75 3.52e-10

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 50.26  E-value: 3.52e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613388928   10 NKAYKIKRMDIANENMLYRLSAFGLTDDAIITIKQKCLFkGPCIIEVNGqQLSIRHCDACSIALEE 75
Cdd:smart00899  9 GEKARIVRIRDEDPELLRRLLELGLVPGTEVTVLRKAPF-GPLVVRVGG-ELALRREEAEKIFVEP 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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