NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|613387994|gb|EZZ91906|]
View 

indole-3-glycerol phosphate synthase [Staphylococcus aureus VET0057R]

Protein Classification

indole-3-glycerol phosphate synthase TrpC( domain architecture ID 10011355)

indole-3-glycerol-phosphate synthase (IGPS) TrpC is an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water

EC:  4.1.1.48
Gene Ontology:  GO:0004425|GO:0000162

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 2.81e-105

indole-3-glycerol phosphate synthase TrpC;


:

Pssm-ID: 234710  Cd Length: 260  Bit Score: 305.54  E-value: 2.81e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   1 MTILEEIVEYKQSLLQNGYYQDKLSTLKSV--NIQNKKSFINTIeQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYE 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARaaAAPPPRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  78 QYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQS 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 158 LEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 613387994 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 2.81e-105

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 305.54  E-value: 2.81e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   1 MTILEEIVEYKQSLLQNGYYQDKLSTLKSV--NIQNKKSFINTIeQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYE 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARaaAAPPPRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  78 QYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQS 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 158 LEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 613387994 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.86e-96

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 283.07  E-value: 1.86e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   2 TILEEIVEYKQSLLQNGYYQDKLSTLKS--VNIQNKKSFINTIEQEPKLVIIAEIKSKSPTVNDLPER-DLSQQISDYEQ 78
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLAELEAraAAAPPPRDFAAALRAAGGPAVIAEIKKASPSKGLIREDfDPAEIARAYEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  79 YGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSL 158
Cdd:COG0134   82 GGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLGM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 159 EVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGE 238
Cdd:COG0134  162 DVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAAAGADAFLVGE 241

                        250
                 ....*....|....*
gi 613387994 239 ALMRCDNLSEFLPQL 253
Cdd:COG0134  242 ALMRAPDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-253 9.22e-92

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 269.72  E-value: 9.22e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  38 FINTIEQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYEQYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDF 116
Cdd:cd00331    1 FKAALKRPGGLGVIAEVKRASPSKGLIrEDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 117 IIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSLEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVE 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613387994 197 HTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGEALMRCDNLSEFLPQL 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-250 8.72e-79

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 237.96  E-value: 8.72e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994    4 LEEIVEYKQSLLQNGYYQDKLSTLKSVNIQN-KKSFINTIEQEP-KLVIIAEIKSKSPTVNDL-PERDLSQQISDYEQYG 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAARAPpTRSFYDALRESRgRPALIAEVKKASPSKGLIrEDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   81 ANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSLEV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  161 LVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGEAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHGANAFLVGESL 240

                         250
                  ....*....|
gi 613387994  241 MRCDNLSEFL 250
Cdd:pfam00218 241 MRQEDVRAAI 250
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
50-244 1.64e-41

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 142.81  E-value: 1.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  50 IIAEIKSKSPTVNDLPERD---LSQQISDYeqyGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVA 126
Cdd:NF041303  49 VIAEVKPTSPTTDGTRDDDpveLAEAMVAG---GAAALSVLTEPEHFGGSPETLRRVREAVDVPVLRKDFLLREAQLDAV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 127 KqagASMILLIVNILSDkQLRELYEYATSQSLEVLVEVHDREELDRAYKINPKLIGVNNRDL----------KRFVTKVE 196
Cdd:NF041303 126 E---ADVVLLIARFVGD-DLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLaklevdlgtfESVAPHVP 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 613387994 197 HTNIILenkqpnhyyISESGIHDTSDVRKILHSGIDGLLIGEALMRCD 244
Cdd:NF041303 202 DDDVTL---------IAESGISTPADVRRMREAGADALLVGSAIMDGD 240
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 2.81e-105

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 305.54  E-value: 2.81e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   1 MTILEEIVEYKQSLLQNGYYQDKLSTLKSV--NIQNKKSFINTIeQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYE 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARaaAAPPPRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  78 QYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQS 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 158 LEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 613387994 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.86e-96

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 283.07  E-value: 1.86e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   2 TILEEIVEYKQSLLQNGYYQDKLSTLKS--VNIQNKKSFINTIEQEPKLVIIAEIKSKSPTVNDLPER-DLSQQISDYEQ 78
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLAELEAraAAAPPPRDFAAALRAAGGPAVIAEIKKASPSKGLIREDfDPAEIARAYEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  79 YGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSL 158
Cdd:COG0134   82 GGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLGM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 159 EVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGE 238
Cdd:COG0134  162 DVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAAAGADAFLVGE 241

                        250
                 ....*....|....*
gi 613387994 239 ALMRCDNLSEFLPQL 253
Cdd:COG0134  242 ALMRAPDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-253 9.22e-92

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 269.72  E-value: 9.22e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  38 FINTIEQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYEQYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDF 116
Cdd:cd00331    1 FKAALKRPGGLGVIAEVKRASPSKGLIrEDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 117 IIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSLEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVE 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613387994 197 HTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGEALMRCDNLSEFLPQL 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-250 8.72e-79

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 237.96  E-value: 8.72e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994    4 LEEIVEYKQSLLQNGYYQDKLSTLKSVNIQN-KKSFINTIEQEP-KLVIIAEIKSKSPTVNDL-PERDLSQQISDYEQYG 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAARAPpTRSFYDALRESRgRPALIAEVKKASPSKGLIrEDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   81 ANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSLEV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  161 LVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIGEAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHGANAFLVGESL 240

                         250
                  ....*....|
gi 613387994  241 MRCDNLSEFL 250
Cdd:pfam00218 241 MRQEDVRAAI 250
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 2-246 3.52e-58

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 191.57  E-value: 3.52e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   2 TILEEIVEYKQSLLQNGYYQDKLSTLKSvNIQN-KKSFINTIeQEPKLVIIAEIKSKSPTV----NDLperDLSQQISDY 76
Cdd:PRK09427   5 TVLAKIVADKAIWVAARKQQQPLASFQN-EIQPsDRSFYDAL-KGPKTAFILECKKASPSKglirDDF---DPAEIARVY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  77 EQYgANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQ 156
Cdd:PRK09427  80 KHY-ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 157 SLEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTnIILENKQP-NHYYISESGIHDTSDVRKiLHSGIDGLL 235
Cdd:PRK09427 159 NMGVLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRT-RELAPLIPaDVIVISESGIYTHAQVRE-LSPFANGFL 236

                        250
                 ....*....|.
gi 613387994 236 IGEALMRCDNL 246
Cdd:PRK09427 237 IGSSLMAEDDL 247
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 3-245 1.16e-44

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 153.39  E-value: 1.16e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   3 ILEEIVEYKQSLLQNGYYQDKLSTLK--SVNIQNKKSFINTIEQE------PKLviIAEIKSKSPTVNDLPERDLSQQIS 74
Cdd:PLN02460  68 ILEEIVWYKDVEVAQMKERKPLYLLKkaLQNAPPARDFVGALRAAhkrtgqPGL--IAEVKKASPSRGVLRENFDPVEIA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  75 D-YEQYGANAVSILTDEKYFGGSFERLQEL-TTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEY 152
Cdd:PLN02460 146 QaYEKGGAACLSVLTDEKYFQGSFENLEAIrNAGVKCPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKI 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 153 ATSQSLEVLVEVHDREELDRAYKINP-KLIGVNNRDLKRFVTKVEHTNIILEN------KQPNHYYISESGIHDTSDVRK 225
Cdd:PLN02460 226 CKSLGMAALIEVHDEREMDRVLGIEGvELIGINNRSLETFEVDISNTKKLLEGergeqiREKGIIVVGESGLFTPDDVAY 305

                        250       260
                 ....*....|....*....|
gi 613387994 226 ILHSGIDGLLIGEALMRCDN 245
Cdd:PLN02460 306 VQNAGVKAVLVGESLVKQDD 325
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 3-246 3.67e-43

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 146.95  E-value: 3.67e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   3 ILEEIVEYKQSLLQngyyqdKLSTLKSVniQNKKSFINTIEQEPKLVIIAEIKSKSPTVNDL-PERDLSQQISDYEQYGA 81
Cdd:PRK13957   4 VLREIIETKQNEIE------KISRWDPL--PDRGLPLRDSLKSRSFSIIAECKRKSPSAGELrADYHPVQIAKTYETLGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  82 NAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLRELYEYATSQSLEVL 161
Cdd:PRK13957  76 SAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMDVL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 162 VEVHDREELDRAYKINPKLIGVNNRDLKRFVTkveHTNIILENK---QPNHYYISESGIHDTSDVRKiLHSGIDGLLIGE 238
Cdd:PRK13957 156 VEVHTEDEAKLALDCGAEIIGINTRDLDTFQI---HQNLVEEVAaflPPNIVKVGESGIESRSDLDK-FRKLVDAALIGT 231


                 ....*...
gi 613387994 239 ALMRCDNL 246
Cdd:PRK13957 232 YFMEKKDI 239
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
50-244 1.64e-41

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 142.81  E-value: 1.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  50 IIAEIKSKSPTVNDLPERD---LSQQISDYeqyGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVA 126
Cdd:NF041303  49 VIAEVKPTSPTTDGTRDDDpveLAEAMVAG---GAAALSVLTEPEHFGGSPETLRRVREAVDVPVLRKDFLLREAQLDAV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 127 KqagASMILLIVNILSDkQLRELYEYATSQSLEVLVEVHDREELDRAYKINPKLIGVNNRDL----------KRFVTKVE 196
Cdd:NF041303 126 E---ADVVLLIARFVGD-DLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLaklevdlgtfESVAPHVP 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 613387994 197 HTNIILenkqpnhyyISESGIHDTSDVRKILHSGIDGLLIGEALMRCD 244
Cdd:NF041303 202 DDDVTL---------IAESGISTPADVRRMREAGADALLVGSAIMDGD 240
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 1-245 2.17e-37

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 139.01  E-value: 2.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994   1 MTILEEIVEykqsllqnGYYQDKLSTLKSVNIQNKKSFINT----------IEQEPKLVIIAEIKSKSPT---VNDLPer 67
Cdd:PRK13802   1 MSVLDELVA--------GALEDQRTRELTVSLEEVKKAAAAapapidatrwLKRADGIPVIAEIKRASPSkghLSDIP-- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  68 DLSQQISDYEQYGANAVSILTDEKYFGGSFERLQELTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLR 147
Cdd:PRK13802  71 DPAALAREYEQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAHGADLVLLIVAALDDAQLK 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 148 ELYEYATSQSLEVLVEVHDREELDRAYKINPKLIGVNNRDLKRFVTKVEHTNIILENKQPNHYYISESGIHDTSDVRKIL 227
Cdd:PRK13802 151 HLLDLAHELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDVIKVAESGVFGAVEVEDYA 230

                        250
                 ....*....|....*...
gi 613387994 228 HSGIDGLLIGEALMRCDN 245
Cdd:PRK13802 231 RAGADAVLVGEGVATADD 248
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 65-237 7.35e-08

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 51.43  E-value: 7.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994  65 PERDLSQQISDYEQYGANAVSILTDEKYFGGSFERLQELTT----KTTLPVLCKDFIIDPLQI-----DVAKQAGASMIL 135
Cdd:cd04722   10 PSGDPVELAKAAAEAGADAIIVGTRSSDPEEAETDDKEVLKevaaETDLPLGVQLAINDAAAAvdiaaAAARAAGADGVE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613387994 136 LIVNILSD--------KQLRELYEyatsqSLEVLVEVHDREELDRAYKINPKLIGVN--NRD---LKRFVTKVEHTNIIL 202
Cdd:cd04722   90 IHGAVGYLaredleliRELREAVP-----DVKVVVKLSPTGELAAAAAEEAGVDEVGlgNGGgggGGRDAVPIADLLLIL 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 613387994 203 ENKQPNHYYISESGIHDTSDVRKILHSGIDGLLIG 237
Cdd:cd04722  165 AKRGSKVPVIAGGGINDPEDAAEALALGADGVIVG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH