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Conserved domains on  [gi|613365652|gb|EZZ69942|]
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hypothetical protein V164_01711 [Staphylococcus aureus USA7]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-85 7.93e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 101.09  E-value: 7.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQ 84
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83


                 .
gi 613365652  85 F 85
Cdd:COG2188   84 F 84
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-85 7.93e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 101.09  E-value: 7.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQ 84
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83


                 .
gi 613365652  85 F 85
Cdd:COG2188   84 F 84
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-70 2.32e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.73  E-value: 2.32e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613365652   6 PKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 1.65e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 73.76  E-value: 1.65e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652    11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-70 6.82e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 6.82e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613365652   12 YNTLYKEIQI----GKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:pfam00392   2 YEQVYARLREdilsGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK09764 PRK09764
GntR family transcriptional regulator;
5-70 3.72e-13

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 66.78  E-value: 3.72e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK09764   4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-95 7.04e-12

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 63.26  E-value: 7.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASS--------M 82
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSArtrfsqnlA 92

                          90
                  ....*....|...
gi 613365652   83 DQFKHPLDQILLA 95
Cdd:TIGR02325  93 DQGREPTGELLLS 105
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-85 7.93e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 101.09  E-value: 7.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQ 84
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83


                 .
gi 613365652  85 F 85
Cdd:COG2188   84 F 84
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-70 2.32e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.73  E-value: 2.32e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613365652   6 PKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
11-96 2.42e-18

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 80.75  E-value: 2.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652  11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQF----K 86
Cdd:COG2186   12 VAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPLALLlaldD 91

                         90
                 ....*....|
gi 613365652  87 HPLDQILLAR 96
Cdd:COG2186   92 ASLRDLLEAR 101
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 1.65e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 73.76  E-value: 1.65e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652    11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-70 6.82e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 6.82e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613365652   12 YNTLYKEIQI----GKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:pfam00392   2 YEQVYARLREdilsGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK09764 PRK09764
GntR family transcriptional regulator;
5-70 3.72e-13

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 66.78  E-value: 3.72e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK09764   4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
11-72 7.33e-13

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 65.71  E-value: 7.33e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613365652  11 IYNTLYKEIQIGKYPSGHALpTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIP 72
Cdd:COG1802   16 VYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
5-85 2.14e-12

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 61.73  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQ 84
Cdd:COG1725    9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERREE 88


                 .
gi 613365652  85 F 85
Cdd:COG1725   89 F 89
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-95 7.04e-12

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 63.26  E-value: 7.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASS--------M 82
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSArtrfsqnlA 92

                          90
                  ....*....|...
gi 613365652   83 DQFKHPLDQILLA 95
Cdd:TIGR02325  93 DQGREPTGELLLS 105
PRK11402 PRK11402
transcriptional regulator PhoB;
5-70 8.55e-12

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 62.93  E-value: 8.55e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613365652   5 QPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 4-96 2.77e-11

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 62.54  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652   4 TQPKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV---IPQTNAQHAS 80
Cdd:COG1167   10 SGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVaarLPAPAPAPRA 89

                         90
                 ....*....|....*.
gi 613365652  81 SMDQFKHPLDQILLAR 96
Cdd:COG1167   90 AAAVAAPALRRLLEAA 105
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 10-95 3.99e-10

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 58.25  E-value: 3.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652  10 TIYNTLYKEIQI-------GKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVI--PQTNAQHAS 80
Cdd:PRK10079   8 TSYPTRYQEIAAkleqelrQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLmrPYDYPLNAQ 87

                         90       100
                 ....*....|....*....|.
gi 613365652  81 S------MDQFKHPLDQILLA 95
Cdd:PRK10079  88 ArfsqnlLDQGSHPTSEKLLS 108
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 26-82 2.05e-09

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 56.31  E-value: 2.05e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 613365652  26 SGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSM 82
Cdd:PRK09990  27 VGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASPL 83
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 26-93 5.91e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.08  E-value: 5.91e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613365652  26 SGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMDQfkhPLDQIL 93
Cdd:PRK10421  22 AGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQNIVQ---PLKTLM 86
PRK10225 PRK10225
Uxu operon transcriptional regulator;
24-83 3.95e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 49.63  E-value: 3.95e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652  24 YPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIPQTNAQHASSMD 83
Cdd:PRK10225  27 YNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSPD 86
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
4-70 1.62e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 47.71  E-value: 1.62e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613365652   4 TQPKFL-TIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK09464   7 RQPKLSdVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 34-68 6.08e-06

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 42.42  E-value: 6.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 613365652   34 KELCARFDVSRMTLRQAIKLLAEDGI-VESTRGKGH 68
Cdd:pfam08279  17 QELAEKLGVSRRTIRRDIKILEELGVpIEAEPGRGY 52
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 19-65 7.87e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 45.78  E-value: 7.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 613365652  19 IQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRG 65
Cdd:PRK03837  26 IRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK11523 PRK11523
transcriptional regulator ExuR;
15-85 3.44e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.68  E-value: 3.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613365652  15 LYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFVIP--QTNAQHASSMDQF 85
Cdd:PRK11523  17 LKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSnqPRHQQAADNNMEF 89
PRK14999 PRK14999
histidine utilization repressor; Provisional
 6-70 6.42e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 6.42e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613365652   6 PKFLTIYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 34-84 1.89e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 41.66  E-value: 1.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 613365652  34 KELCARFDVSRMTLRQAIKLLAEDGIVESTRGkGhfVIPQTNAQHASSMDQ 84
Cdd:COG1349   23 EELAERLGVSEETIRRDLAELEEQGLLRRVHG-G--AVLVSSAAAEPPFAE 70
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
21-67 2.05e-04

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 40.21  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 613365652  21 IGKYPSGHALPTeKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKG 67
Cdd:COG1959   16 LALHPGGEPVTS-KEIAERQGISPSYLEKILQKLRKAGLVESVRGPG 61
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 19-67 5.79e-04

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 38.69  E-value: 5.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 613365652   19 IQIGKYPSGHALPTEkELCARFDVSRMTLRQAIKLLAEDGIVESTRGKG 67
Cdd:pfam02082  13 LYLALHPGGEPVTSE-EIAERQNISPVYLEKILAKLRKAGLVESVRGAG 60
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
34-65 1.72e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 35.66  E-value: 1.72e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 613365652    34 KELCARFDVSRMTLRQAIKLLAEDGIVESTRG 65
Cdd:smart00420  18 EELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
22-144 2.65e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 37.93  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652  22 GKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV----------IPQTNAQhassMDQFKHP--L 89
Cdd:PRK04984  23 NRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVnnfwetsglnILETLAR----LDHDSVPqlI 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 613365652  90 DQILLARVSMSSInyrvdleseYTNHLFANHPSAVIAMeryYQKKDNPSKQADAF 144
Cdd:PRK04984  99 DNLLSARTNISAI---------FIRTAFRNNPEKALEV---LATAEELEDTAEAF 141
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
34-65 2.78e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 35.31  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 613365652   34 KELCARFDVSRMTLRQAIKLLAEDGIVESTRG 65
Cdd:pfam08220  18 EELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
HTH_41 pfam14502
Helix-turn-helix domain;
27-68 2.99e-03

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 34.78  E-value: 2.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 613365652   27 GHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRgKGH 68
Cdd:pfam14502   3 GERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQLER-RGH 43
BirA COG1654
Biotin operon repressor [Transcription];
22-67 3.30e-03

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 38.04  E-value: 3.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 613365652  22 GKYPSGhalpteKELCARFDVSRMTLRQAIKLLAEDGI-VESTRGKG 67
Cdd:COG1654   16 GEFHSG------EELAEELGVSRAAVWKHIKALRELGYeIESVPGKG 56
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 11-70 6.25e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.33  E-value: 6.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 613365652  11 IYNTLYKEIQIGKYPSGHALPTEKELCARFDVSRMTLRQAIKLLAEDGIVESTRGKGHFV 70
Cdd:PRK15481  10 IFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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