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Conserved domains on  [gi|613363405|gb|EZZ67712|]
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hypothetical protein V164_02378 [Staphylococcus aureus USA7]

Protein Classification

Mini-ribonuclease 3( domain architecture ID 10004964)

Mini-ribonuclease 3 is involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MrnC COG1939
23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
5-134 1.83e-65

23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA maturation mini-RNase III is part of the Pathway/BioSystem: 23S rRNA modification


:

Pssm-ID: 441542  Cd Length: 130  Bit Score: 194.58  E-value: 1.83e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   5 QDNHIKLLNPLTLAYMGDAVLDQYVRTYIVLKLKSKPNKLHQMSKKYVSAKSQAQTLEYLMEQewFTDEEMDILKRGRNA 84
Cdd:COG1939    1 SEKDVKQLSPLALAYIGDAVYELYVRTYLLLKGNTKVNDLHKLAVKYVSAKAQAKLLRKLLPL--LTEEELDIVRRGRNA 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 613363405  85 KSHTKAKNTDVQTYRKSSAIEAVIGFLYLEKREERLEALLNEIITIVNER 134
Cdd:COG1939   79 KSGTVPKNADVQTYRYATGFEALIGYLYLTGQTERLEELLELAIEEIEEE 128
 
Name Accession Description Interval E-value
MrnC COG1939
23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
5-134 1.83e-65

23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA maturation mini-RNase III is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 441542  Cd Length: 130  Bit Score: 194.58  E-value: 1.83e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   5 QDNHIKLLNPLTLAYMGDAVLDQYVRTYIVLKLKSKPNKLHQMSKKYVSAKSQAQTLEYLMEQewFTDEEMDILKRGRNA 84
Cdd:COG1939    1 SEKDVKQLSPLALAYIGDAVYELYVRTYLLLKGNTKVNDLHKLAVKYVSAKAQAKLLRKLLPL--LTEEELDIVRRGRNA 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 613363405  85 KSHTKAKNTDVQTYRKSSAIEAVIGFLYLEKREERLEALLNEIITIVNER 134
Cdd:COG1939   79 KSGTVPKNADVQTYRYATGFEALIGYLYLTGQTERLEELLELAIEEIEEE 128
Ribonuclease_3 pfam00636
Ribonuclease III domain;
15-116 9.38e-25

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 90.41  E-value: 9.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   15 LTLAYMGDAVLDQYVRTYIVLKL-KSKPNKLHQMSKKYVSAKSQAQTLEYLMEQEWFTDEEMDIlkRGRNAKSHTKAKNT 93
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFpDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELDI--RRRNNALGKGPKRA 78
                          90       100
                  ....*....|....*....|...
gi 613363405   94 DVQTYRKSSAIEAVIGFLYLEKR 116
Cdd:pfam00636  79 DGKEKVLADAFEALIGALYLDGG 101
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
7-128 1.28e-09

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 52.62  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   7 NHIKLLNPLTLAYMGDAVLDQYVRTYIVLKLKSK-PNKLHQMSKKYVSAKSQAQTLEYLMEQEWFTDEEMDILKRGRNAk 85
Cdd:cd00593   14 NEHGRFNNERLEFLGDAVLELVVTEYLFKKFPDLsEGDLTRLRSALVSNETLARLARELGLGKYLRLGKGEEKSGGRLR- 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 613363405  86 shtkakntdvqTYRKSSAIEAVIGFLYLEKREERLEALLNEII 128
Cdd:cd00593   93 -----------PKILADVFEALIGAIYLDGGFEAARKFLLRLL 124
RIBOc smart00535
Ribonuclease III family;
3-128 1.64e-09

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 52.22  E-value: 1.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405     3 NQQDNHiklLNPLTLAYMGDAVLDQYVRTYIVLKLKSKPNK-LHQMSKKYVSAKSQAQTLEYLMEQEWftdeemdiLKRG 81
Cdd:smart00535  11 SYSNEH---EHNERLEFLGDAVLELVVTEYLYKKYPDLSEGdLSRLRSALVSNETLARLAKKLGLGEF--------IRLG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 613363405    82 RNAKSHTKAKNTdvqtYRKSSAIEAVIGFLYLEKREERLEALLNEII 128
Cdd:smart00535  80 RGEAISGGRDKP----KILADVFEALIGAIYLDSGLEAAREFIRDLL 122
 
Name Accession Description Interval E-value
MrnC COG1939
23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
5-134 1.83e-65

23S rRNA maturation mini-RNase III [Translation, ribosomal structure and biogenesis]; 23S rRNA maturation mini-RNase III is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 441542  Cd Length: 130  Bit Score: 194.58  E-value: 1.83e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   5 QDNHIKLLNPLTLAYMGDAVLDQYVRTYIVLKLKSKPNKLHQMSKKYVSAKSQAQTLEYLMEQewFTDEEMDILKRGRNA 84
Cdd:COG1939    1 SEKDVKQLSPLALAYIGDAVYELYVRTYLLLKGNTKVNDLHKLAVKYVSAKAQAKLLRKLLPL--LTEEELDIVRRGRNA 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 613363405  85 KSHTKAKNTDVQTYRKSSAIEAVIGFLYLEKREERLEALLNEIITIVNER 134
Cdd:COG1939   79 KSGTVPKNADVQTYRYATGFEALIGYLYLTGQTERLEELLELAIEEIEEE 128
Ribonuclease_3 pfam00636
Ribonuclease III domain;
15-116 9.38e-25

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 90.41  E-value: 9.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   15 LTLAYMGDAVLDQYVRTYIVLKL-KSKPNKLHQMSKKYVSAKSQAQTLEYLMEQEWFTDEEMDIlkRGRNAKSHTKAKNT 93
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFpDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELDI--RRRNNALGKGPKRA 78
                          90       100
                  ....*....|....*....|...
gi 613363405   94 DVQTYRKSSAIEAVIGFLYLEKR 116
Cdd:pfam00636  79 DGKEKVLADAFEALIGALYLDGG 101
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
7-128 1.28e-09

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 52.62  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405   7 NHIKLLNPLTLAYMGDAVLDQYVRTYIVLKLKSK-PNKLHQMSKKYVSAKSQAQTLEYLMEQEWFTDEEMDILKRGRNAk 85
Cdd:cd00593   14 NEHGRFNNERLEFLGDAVLELVVTEYLFKKFPDLsEGDLTRLRSALVSNETLARLARELGLGKYLRLGKGEEKSGGRLR- 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 613363405  86 shtkakntdvqTYRKSSAIEAVIGFLYLEKREERLEALLNEII 128
Cdd:cd00593   93 -----------PKILADVFEALIGAIYLDGGFEAARKFLLRLL 124
RIBOc smart00535
Ribonuclease III family;
3-128 1.64e-09

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 52.22  E-value: 1.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613363405     3 NQQDNHiklLNPLTLAYMGDAVLDQYVRTYIVLKLKSKPNK-LHQMSKKYVSAKSQAQTLEYLMEQEWftdeemdiLKRG 81
Cdd:smart00535  11 SYSNEH---EHNERLEFLGDAVLELVVTEYLYKKYPDLSEGdLSRLRSALVSNETLARLAKKLGLGEF--------IRLG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 613363405    82 RNAKSHTKAKNTdvqtYRKSSAIEAVIGFLYLEKREERLEALLNEII 128
Cdd:smart00535  80 RGEAISGGRDKP----KILADVFEALIGAIYLDSGLEAAREFIRDLL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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