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Conserved domains on  [gi|613312507|gb|EZZ17561|]
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hypothetical protein U935_01236 [Staphylococcus aureus Sau 46]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 3.12e-43

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 144.00  E-value: 3.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   2 YSVISKILNFILVKMSKSLYVIGKDNIPKDSKYVVTCTHESYNEVIMLGMALyPNQIHYMAKKELFKNKWIGKFLTSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  82 FPVDRENPGPS--TLKRPINLLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYVG----PTKIHGLLT 154
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRlLPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 613312507 155 GQAYINIGKPIDINDLPKDlKRNERIDYITKEIETRTAKLQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 3.12e-43

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 144.00  E-value: 3.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   2 YSVISKILNFILVKMSKSLYVIGKDNIPKDSKYVVTCTHESYNEVIMLGMALyPNQIHYMAKKELFKNKWIGKFLTSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  82 FPVDRENPGPS--TLKRPINLLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYVG----PTKIHGLLT 154
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRlLPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 613312507 155 GQAYINIGKPIDINDLPKDlKRNERIDYITKEIETRTAKLQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 22-188 4.23e-37

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 127.39  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGMALyPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENP--GPSTLKRPIN 99
Cdd:cd07989   14 VEGLENLPPKGPVIIVANHQSYLDPLVLGAAL-PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrsAREALREAIE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507 100 LLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYVG-----PTKIHGLLTGQAYINIGKPIDINDLPkd 173
Cdd:cd07989   93 ALKEGESVVIFPEGTRSRDGElLPFKSGAFRLAKEAGVPIVPVAISGtwgslPKGKKLPRPGRVTVRIGEPIPPEGLE-- 170

                        170
                 ....*....|....*
gi 613312507 174 lKRNERIDYITKEIE 188
Cdd:cd07989  171 -LAEEDRKELREKVR 184
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 22-144 3.93e-33

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 115.52  E-value: 3.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGmALYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDREN--PGPSTLKRPIN 99
Cdd:TIGR00530   6 VVGPENLPAKSPVLVVANHQSNLDPLTLS-AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKAAIE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 613312507  100 LLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYV 144
Cdd:TIGR00530  85 VLKQGRSIGVFPEGTRSRGRDiLPFKKGAFHIAIKAGVPILPVVLS 130
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 22-144 1.40e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 96.19  E-value: 1.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGMALYP--NQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPG--PSTLKRP 97
Cdd:pfam01553   4 VHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGTLEYL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 613312507   98 INLLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYV 144
Cdd:pfam01553  84 VELLREGKLVVIFPEGTRSREGElLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 34-145 8.57e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.57  E-value: 8.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507    34 YVVTCTHESYNEVIMLGMALYP--NQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPGP--STLKRPINLLKDNKTVGI 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 613312507   110 FPTGSRTSQEGA-PLKRGASTIAMLSKSPILPVAYVG 145
Cdd:smart00563  81 FPEGTRSRPGKLlPFKKGAARLALEAGVPIVPVAIRG 117
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
22-183 8.68e-09

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 54.59  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPK-DSKYVVTCTHESYNEVIMLgMALYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPgpSTLKRPINL 100
Cdd:PRK06814  443 VKGLENLQKaGKKAVIAANHVSFLDGPLL-AAYLPEEPTFAIDTDIAKAWWVKPFLKLAKALPVDPTNP--MATRTLIKE 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  101 LKDNKTVGIFPTGsRTSQEGAPLK--RGASTIAMLSKSPILPVAYVGPTKIH-GLLTGQA--------YINIGKPIDIND 169
Cdd:PRK06814  520 VQKGEKLVIFPEG-RITVTGSLMKiyDGPGMIADKAGAMVVPVRIDGLQFTHfSRLKNQVrrkwfpkvTVTILPPVKLAV 598

                         170
                  ....*....|....
gi 613312507  170 LPkDLKRNERIDYI 183
Cdd:PRK06814  599 DP-ELKGRERRSAA 611
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 3.12e-43

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 144.00  E-value: 3.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   2 YSVISKILNFILVKMSKSLYVIGKDNIPKDSKYVVTCTHESYNEVIMLGMALyPNQIHYMAKKELFKNKWIGKFLTSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  82 FPVDRENPGPS--TLKRPINLLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYVG----PTKIHGLLT 154
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRlLPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 613312507 155 GQAYINIGKPIDINDLPKDlKRNERIDYITKEIETRTAKLQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 22-188 4.23e-37

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 127.39  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGMALyPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENP--GPSTLKRPIN 99
Cdd:cd07989   14 VEGLENLPPKGPVIIVANHQSYLDPLVLGAAL-PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrsAREALREAIE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507 100 LLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYVG-----PTKIHGLLTGQAYINIGKPIDINDLPkd 173
Cdd:cd07989   93 ALKEGESVVIFPEGTRSRDGElLPFKSGAFRLAKEAGVPIVPVAISGtwgslPKGKKLPRPGRVTVRIGEPIPPEGLE-- 170

                        170
                 ....*....|....*
gi 613312507 174 lKRNERIDYITKEIE 188
Cdd:cd07989  171 -LAEEDRKELREKVR 184
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 22-144 3.93e-33

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 115.52  E-value: 3.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGmALYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDREN--PGPSTLKRPIN 99
Cdd:TIGR00530   6 VVGPENLPAKSPVLVVANHQSNLDPLTLS-AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKAAIE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 613312507  100 LLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYV 144
Cdd:TIGR00530  85 VLKQGRSIGVFPEGTRSRGRDiLPFKKGAFHIAIKAGVPILPVVLS 130
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 22-144 1.40e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 96.19  E-value: 1.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGMALYP--NQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPG--PSTLKRP 97
Cdd:pfam01553   4 VHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGTLEYL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 613312507   98 INLLKDNKTVGIFPTGSRTSQEG-APLKRGASTIAMLSKSPILPVAYV 144
Cdd:pfam01553  84 VELLREGKLVVIFPEGTRSREGElLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 34-145 8.57e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.57  E-value: 8.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507    34 YVVTCTHESYNEVIMLGMALYP--NQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPGP--STLKRPINLLKDNKTVGI 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 613312507   110 FPTGSRTSQEGA-PLKRGASTIAMLSKSPILPVAYVG 145
Cdd:smart00563  81 FPEGTRSRPGKLlPFKKGAARLALEAGVPIVPVAIRG 117
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 18-198 2.48e-21

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 86.93  E-value: 2.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  18 KSLYVIGKDNIPKDSKYVVTCTHEsyNEVI--MLGMALYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPGPSTLK 95
Cdd:cd07992   14 RRITVVGRENVPKDGPVIFLGNHP--NALIdpLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRPKDLARGGI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  96 RPIN----------LLKDNKTVGIFPTG-SRTSQEGAPLKRGASTIAM-LSKSP-----ILPVA--YVGPTKihglLTGQ 156
Cdd:cd07992   92 GKISnaavfdavgeALKAGGAIGIFPEGgSHDRPRLLPLKAGAARMALeALEAGqkdvkIVPVGlnYEDKSR----FRSR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 613312507 157 AYINIGKPIDIND-LPKDLKRNeridyitkEIETRTAKLQQEL 198
Cdd:cd07992  168 VLVEFGKPISVSAfEEAEASRD--------VEKKLINQLEAEL 202
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 20-188 4.78e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 77.84  E-value: 4.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  20 LYVIGKDNIPKDSKYVVTCTHESYNEVIMLGMALY---PNQIHYMAKKELFKNKWigkFLTSLNAFPVDRENPGP--STL 94
Cdd:cd06551   14 LEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLErglRRDVYGLMDEELLERYP---FFTRLGAFSVDRDSPRSaaKSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  95 KRPINLLKD-NKTVGIFPTGSRTSQEGAPL--KRGASTIAMLSKSPILPVA--YvgpTKIHGLLTGQAYINIGKPIDIND 169
Cdd:cd06551   91 KYVARLLSKpGSVVWIFPEGTRTRRDKRPLqfKPGVAHLAEKAGVPIVPVAlrY---TFELFEQFPEIFVRIGPPIPYAE 167

                        170
                 ....*....|....*....
gi 613312507 170 lpkDLKRNERIDYITKEIE 188
Cdd:cd06551  168 ---TALGEELAAELANRLT 183
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 28-176 1.04e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 54.92  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  28 IPKDSKYVVTCT-HESyNE---VIMLGMALYPNQIHYMAKKELFKNKWiGKFLTSLNAFPVDRENPGpSTLKRPINLLKD 103
Cdd:cd07988   16 PPNKPKFVVIGApHTS-NWdfvLGLLAAFALGLKISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAG-GLVEQVVEEFRR 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613312507 104 NKT--VGIFPTGSRTSQEgaPLKRGASTIAMLSKSPILPVAYVGPTKIhglltgqayINIGKPIDI-NDLPKDLKR 176
Cdd:cd07988   93 REEfvLAIAPEGTRSKVD--KWKTGFYHIARGAGVPILLVYLDYKRKT---------VGIGPLFEPsGDIEADLAA 157
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
22-183 8.68e-09

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 54.59  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   22 VIGKDNIPK-DSKYVVTCTHESYNEVIMLgMALYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPgpSTLKRPINL 100
Cdd:PRK06814  443 VKGLENLQKaGKKAVIAANHVSFLDGPLL-AAYLPEEPTFAIDTDIAKAWWVKPFLKLAKALPVDPTNP--MATRTLIKE 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  101 LKDNKTVGIFPTGsRTSQEGAPLK--RGASTIAMLSKSPILPVAYVGPTKIH-GLLTGQA--------YINIGKPIDIND 169
Cdd:PRK06814  520 VQKGEKLVIFPEG-RITVTGSLMKiyDGPGMIADKAGAMVVPVRIDGLQFTHfSRLKNQVrrkwfpkvTVTILPPVKLAV 598

                         170
                  ....*....|....
gi 613312507  170 LPkDLKRNERIDYI 183
Cdd:PRK06814  599 DP-ELKGRERRSAA 611
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 3-169 1.69e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 49.73  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507   3 SVISKILNFILVKMSKSLYVIGKDNIPK-DSKYVVTCTHESYNEVIMLGMALYPnqIHYMAKKELFKNKWIGKFLTSLNA 81
Cdd:PLN02901  20 HFINKVWATLSTSPFYKIEVEGLENLPSpDEPAVYVSNHQSFLDIYTLFHLGRP--FKFISKTSIFLIPIIGWAMYMTGH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  82 FPVDRENPGPS--TLKRPINLLKDNKTVGIFPTGSRtSQEG--APLKRGASTIAMLSKSPILPVAYVGPTKI------HG 151
Cdd:PLN02901  98 IPLKRMDRRSQleCLKRCMELLKKGASVFFFPEGTR-SKDGklAAFKKGAFSVAAKTGVPVVPITLVGTGKImpngkeGI 176

                        170
                 ....*....|....*...
gi 613312507 152 LLTGQAYINIGKPIDIND 169
Cdd:PLN02901 177 LNPGSVKVVIHPPIEGSD 194
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 9-141 1.66e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 48.00  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507    9 LNFILVKMSKSLY---VIGKDNIPKDSKYVVTCTHESYNEVIMLGMAlYPNQIHYMAKKELFKNKWIGKFLTSLNAFPVd 85
Cdd:PRK08633  415 LRFLLLLLMHTRYrlrVEGRENIPAKGGALLLGNHVSWIDWALLQAA-SPRPIRFVMERSIYEKWYLKWFFKLFGVIPI- 492

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 613312507   86 rENPGPSTLKRPI-NLLKDNKTVGIFPTG--SRTSQEGaPLKRGASTIAMLSKSPILPV 141
Cdd:PRK08633  493 -SSGGSKESLEFIrKALDDGEVVCIFPEGaiTRNGQLN-EFKRGFELIVKGTDVPIIPF 549
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 22-153 2.96e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 43.05  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  22 VIGKDNIPKDSKYVVTCTHESYNEVIMLGMALYPN-----QIHYMAKKELFKNKWIGKFLTSLNAFPVDRENPgpstlkr 96
Cdd:cd07987   10 VRGLENIPDEGPALLVHPHGGLPIDGALLAAAFLLlfpgrLPRALADHFLFPLPGLRDLLRRLGAVPGSRENC------- 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613312507  97 pINLLKDNKTVGIFPTGSRTSQEGAPL--------KRGASTIAMLSKSPILPVAYVGPTKIHGLL 153
Cdd:cd07987   83 -VRLLREGELVLIFPGGAREALKSKREeyyllwkkRKGFARLALRAGAPIVPVFTFGEEELFRVL 146
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 45-144 8.66e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 41.82  E-value: 8.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  45 EVIMLGMALYPNQIHYMAKKelFKNKWIGKFLTSL----NAFPVDRENpgpsTLKRPINLLKDNKTVGIFPTGSRTSQEG 120
Cdd:cd07984   33 ELAGLALALLGYPVTVVYRP--LKNPLLDRLITRGrerfGARLIPRGG----GLRELIRALKKGEIVGILPDQDPGRKGG 106

                         90       100       110
                 ....*....|....*....|....*....|...
gi 613312507 121 APLK---------RGASTIAMLSKSPILPVAYV 144
Cdd:cd07984  107 VFVPffgrpaatpTGPARLALKTGAPVVPAFAY 139
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 61-200 4.01e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 40.00  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  61 MAKKELFKNKWIGKFLTSLNAFPVDREN--PGPSTLKRPINLLKDNK-TVGIFPTGSRTSQEGA-PLKRGASTIAMLSKS 136
Cdd:PRK15018  93 VGKKSLLWIPFFGQLYWLTGNLLIDRNNrtKAHGTIAEVVNHFKKRRiSIWMFPEGTRSRGRGLlPFKTGAFHAAIAAGV 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613312507 137 PILPVAYVGPT---KIHGLLTGQAYINIGKPIDINDLPKDLKRnERIDYITKEIETRTAKLQQELHE 200
Cdd:PRK15018 173 PIIPVCVSTTSnkiNLNRLHNGLVIVEMLPPIDVSQYGKDQVR-ELAAHCRSIMEQKIAELDKEVAE 238
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 21-142 1.82e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 37.97  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613312507  21 YVI---GKDNIPKDSKYVVtCTHESYNEVIMLGMALYPNqihYMAKKELFKNKWIGKFLTSLNAFPVDRENPGPST---- 93
Cdd:cd07991   11 YVIkvhGKPDPPEAPRIIV-ANHTSFIDPLILFSDLFPS---IVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKkvve 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 613312507  94 -LKRpINLLKDNKTVGIFPTGSRTSQEG-APLKRGastiAMLSKSPILPVA 142
Cdd:cd07991   87 eIKE-RATDPNWPPILIFPEGTTTNGKAlIMFKKG----AFEPGVPVQPVA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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