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Conserved domains on  [gi|613307942|gb|EZZ13025|]
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hypothetical protein U935_02287 [Staphylococcus aureus Sau 46]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-322 6.95e-85

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 258.08  E-value: 6.95e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  24 SLCVGSVMIHPIDAIKGIF-----TQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAA 98
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLgpdgdPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  99 VIIIMIFPTAPLFVLPIGSFLGAFAVSLFLsFLISKYDVKGS--KLALIGLAIGAICTAIVQFLLIR-NPLEANKALVWL 175
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLV-YLLARRGGGLSplRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 176 TGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGL 255
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613307942 256 IAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-322 6.95e-85

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 258.08  E-value: 6.95e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  24 SLCVGSVMIHPIDAIKGIF-----TQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAA 98
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLgpdgdPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  99 VIIIMIFPTAPLFVLPIGSFLGAFAVSLFLsFLISKYDVKGS--KLALIGLAIGAICTAIVQFLLIR-NPLEANKALVWL 175
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLV-YLLARRGGGLSplRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 176 TGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGL 255
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613307942 256 IAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
7-322 8.39e-74

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 229.93  E-value: 8.39e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   7 IRRYSLITILLIVSIFISLCVGSVMIhPIDAIKGIFTQDD---FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLA 83
Cdd:PRK09777   3 IALVIFITLALAGCALLSLRMGVIPL-PWRALLTDWQAGDehyYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  84 SPDVIGISKGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKYdvKGSKLALIGLAIGAICTAIVQFLLIR 163
Cdd:PRK09777  82 SPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTH--QPMKLALTGVALSALWASLTDYLMLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 164 NPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSA 243
Cdd:PRK09777 160 RPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATG 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613307942 244 ISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:PRK09777 240 VAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 16-320 1.53e-71

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 223.94  E-value: 1.53e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   16 LLIVSIFISLCVGSVMIHPIDAIKGIFTQDD----FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGIS 91
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDslaaLIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   92 KGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKY-DVKGSKLALIGLAIGAICTAIVQFLLIRNPLEANK 170
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRgGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  171 ALV-WLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGG 249
Cdd:pfam01032 161 SILfWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613307942  250 ISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRR 320
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 57-318 3.38e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 3.38e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  57 TLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKYD 136
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 137 VKGSKLALIGLAIGAICTAIVQFLLIRNPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDA 216
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 217 VATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHp 296
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                        250       260
                 ....*....|....*....|..
gi 613307942 297 PLDIPVGVIIAIIGAPYFLILL 318
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 24-322 6.95e-85

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 258.08  E-value: 6.95e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  24 SLCVGSVMIHPIDAIKGIF-----TQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAA 98
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLgpdgdPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  99 VIIIMIFPTAPLFVLPIGSFLGAFAVSLFLsFLISKYDVKGS--KLALIGLAIGAICTAIVQFLLIR-NPLEANKALVWL 175
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLV-YLLARRGGGLSplRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 176 TGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGL 255
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613307942 256 IAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
7-322 8.39e-74

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 229.93  E-value: 8.39e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   7 IRRYSLITILLIVSIFISLCVGSVMIhPIDAIKGIFTQDD---FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLA 83
Cdd:PRK09777   3 IALVIFITLALAGCALLSLRMGVIPL-PWRALLTDWQAGDehyYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  84 SPDVIGISKGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKYdvKGSKLALIGLAIGAICTAIVQFLLIR 163
Cdd:PRK09777  82 SPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTH--QPMKLALTGVALSALWASLTDYLMLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 164 NPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSA 243
Cdd:PRK09777 160 RPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATG 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613307942 244 ISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:PRK09777 240 VAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 16-320 1.53e-71

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 223.94  E-value: 1.53e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   16 LLIVSIFISLCVGSVMIHPIDAIKGIFTQDD----FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGIS 91
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDslaaLIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   92 KGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKY-DVKGSKLALIGLAIGAICTAIVQFLLIRNPLEANK 170
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRgGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  171 ALV-WLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGG 249
Cdd:pfam01032 161 SILfWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613307942  250 ISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRR 320
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
12-320 5.58e-68

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 224.33  E-value: 5.58e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  12 LITILLIVSIFISLCVGSVMihpiDAIKGIFTQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGIS 91
Cdd:PRK10577 360 ALGLLLLLALVVALSFGRDA----HGWNWLSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGIS 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  92 KGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKYDVKGSKLALIGLAIGAICTAIVQFLLIRNPLEANKA 171
Cdd:PRK10577 436 SGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQL 515

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 172 LVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGGIS 251
Cdd:PRK10577 516 LTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLS 595

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613307942 252 FLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRR 320
Cdd:PRK10577 596 FVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 12-321 2.26e-67

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 214.21  E-value: 2.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  12 LITILLIVSIFISLCVGSVMIHPIDAIKGIFTQDD----FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDV 87
Cdd:COG4779   28 VLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDpgasFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  88 IGISKGASLAAVIIIMIFPTAPLFVlPIGSFLGAFAVSLFLSFLISKYDVKGSKLALIGLAIGAICTAIVQFLLIRNPLE 167
Cdd:COG4779  108 IGITAGASAGAVAAIVVLGGSGLAV-ALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLTAVNSYLLTRADLE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 168 -ANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISV 246
Cdd:COG4779  187 dAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAA 266

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613307942 247 VGGISFLGLIAPHIARQLIGNKTLHVIImSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRRM 321
Cdd:COG4779  267 AGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIRE 340
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
12-322 5.25e-49

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 173.49  E-value: 5.25e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  12 LITILLIVSIFISLCVGSVMIHPIDAIKGIFTQDD-----FILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPD 86
Cdd:PRK10577  16 LLALLLLLALALTLTQLSAALPLSQWLQALWGPDAddleqLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  87 VIGISKGASLAAVIIIMIFPTAPLFVLPIGSFLGAfAVSLFLSFLIS-KYDVKGSKLALIGLAIGAICTAIVQFLLIRNP 165
Cdd:PRK10577  96 TLGVAAGAQLALVLATLFAPALLALASQLAAFAGG-LLAAALVFALAgGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNE 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 166 LEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAIS 245
Cdd:PRK10577 175 QYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVS 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613307942 246 VVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPL--DIPVGVIIAIIGAPYFLILLRRMK 322
Cdd:PRK10577 255 AVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLLPRLR 333
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
9-320 8.79e-48

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 162.94  E-value: 8.79e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   9 RYSLITILLIVSIFISL-CVGSVMIHPIDAIKGIFTQDDFILNEY-----RIPRTLLGIIIGSSLAISGAIIQAVIRNPL 82
Cdd:PRK11228   1 LWGLPVAALIGLFWLSLfCYSAIPISAADALNALLPGHTPTLPEAlvqnlRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  83 ASPDVIGISKGASLAAVIIIMIFPtAPLFVLPIgSFLGAF--AVSLFLSFLIS---KYDVKGSKLALIGLAIGAICTAIV 157
Cdd:PRK11228  81 ASPSLLGINSGAALAMALTSALSP-TPFAGYSL-AFIAACggGLSWLLVMTAGggwRHTHDRNRLILAGIALSALCMALT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 158 QFLLIRNPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAV 237
Cdd:PRK11228 159 RITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 238 ILAGSAISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLIL 317
Cdd:PRK11228 239 LLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318


                 ...
gi 613307942 318 LRR 320
Cdd:PRK11228 319 ARR 321
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 57-318 3.38e-46

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 156.95  E-value: 3.38e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  57 TLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAAVIIIMIFPTAPLFVLPIGSFLGAFAVSLFLSFLISKYD 136
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 137 VKGSKLALIGLAIGAICTAIVQFLLIRNPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDA 216
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 217 VATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHp 296
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                        250       260
                 ....*....|....*....|..
gi 613307942 297 PLDIPVGVIIAIIGAPYFLILL 318
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYLL 261
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 8-320 2.10e-45

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 157.04  E-value: 2.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   8 RRYSLITILLIVSIFISLCVGSVMIHPIDAIKGiftQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDV 87
Cdd:PRK03784  16 RWLLGLSVLLLLALLLSLCAGEQWISPGDWLSP---RGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  88 IGISKGASLAAVIIIMIFP-TAPLFVLPIGSFLGAFAVSLFLSFLISKYDVKGSKLALIGLAIGAICTAIVQFLL-IRNP 165
Cdd:PRK03784  93 LGVSNGAGVALVAAVLLGQgLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSALMTWAVyFSTS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 166 LEANKALVWLTGSLYGHDMSNIYTILPwFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAIS 245
Cdd:PRK03784 173 LDLRQLMYWMMGGFGGVDWRQSWLMLA-LLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVA 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613307942 246 VVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLILLRR 320
Cdd:PRK03784 252 LAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLR 326
btuC PRK09535
cobalamin ABC transporter permease BtuC;
48-320 2.67e-40

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 144.51  E-value: 2.67e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  48 ILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGISKGASLAAVIIImIFPTAPLFVLPIGSFLGAFaVSLF 127
Cdd:PRK09535  90 IVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAI-VLPLAVPFGLQAAAFAGAL-VAAF 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 128 LSFLISKYDVKG--SKLALIGLAIGAICTAIVQFLLIRNPLEANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLS 205
Cdd:PRK09535 168 GVYAIATENGRTpvATLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYA 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 206 YQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVVGGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLT 285
Cdd:PRK09535 248 RDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLV 327

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 613307942 286 FGDGLARGihPPLDIPVGVIIAIIGAPYFLILLRR 320
Cdd:PRK09535 328 ATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
7-320 6.34e-36

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 132.14  E-value: 6.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942   7 IRRYSLITILLIVSI-----FISLCVGSVMIHPIDAIKGIF----TQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAV 77
Cdd:PRK10440   4 VSRRLLITCLLLLAAcvaagLWGLRSGAVTLETSQVFAALMgdapRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  78 IRNPLASPDVIGISKGASLAAVIIIMIFpTAPLFVLPIGSFLGAFAVSLFLSFLISKYDVKGSKLALIGLAIGAICTAIV 157
Cdd:PRK10440  84 MRNPLGSPDVMGFNTGAWSGVLVAMVLF-GQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 158 QFLLIRNPLE-ANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILA 236
Cdd:PRK10440 163 TWLLLKASLEtALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 237 VILAGSAISVVGGISFLGLIAPHIARQLIGNKTLhVIIMSGLIGAILLTFGDGLARGIHPPLDIPVGVIIAIIGAPYFLI 316
Cdd:PRK10440 243 VVLTAAATALAGPISFIALVAPHIARRLSGTARW-GLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIV 321


                 ....
gi 613307942 317 LLRR 320
Cdd:PRK10440 322 LLIQ 325
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
15-320 9.73e-35

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 129.06  E-value: 9.73e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  15 ILLIVSIFISLCVGSVMIHP---IDAIKGI-FTQDDFILNEYRIPRTLLGIIIGSSLAISGAIIQAVIRNPLASPDVIGI 90
Cdd:PRK10441  18 LLLIIATALSLLIGAKSLPAsvvLEALSGTcQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942  91 SKGASLAAVIIIMIFP-TAPLFVLPIgSFLGAFAVSLFLSFLISKYDVKGS--KLALIGLAIGAICTAIVQFLLIRNPLE 167
Cdd:PRK10441  98 NAGASFAIVLGAALFGySSAQEQLAM-AFAGALVASLIVAFTGSQGGGQLSpvRLTLAGVALAAVLEGLTSGIALLNPDV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613307942 168 ANKALVWLTGSLYGHDMSNIYTILPWFLITIPIIILLSYQLDVLNLGDAVATALGLKVKTIKMLLLILAVILAGSAISVV 247
Cdd:PRK10441 177 YDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVV 256

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613307942 248 GGISFLGLIAPHIARQLIGNKTLHVIIMSGLIGAILLTFGDGLARGIHPPlDIPVGVIIAIIGAPYFLILLRR 320
Cdd:PRK10441 257 GPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLVPG-ELRVSVVSAFIGAPVLIFLVRR 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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