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Conserved domains on  [gi|612908243|gb|EZV19884|]
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hypothetical protein U926_01005 [Staphylococcus aureus 12S00881]

Protein Classification

ABC transporter permease( domain architecture ID 10003065)

ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of substrates including gylcine betaine, choline, and carnitine

Gene Ontology:  GO:0140359|GO:0042626|GO:0055085|GO:0016020
PubMed:  25750732|24638992|31571164|27273632|26517919|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-208 1.04e-82

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 244.58  E-value: 1.04e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   1 MIEFLHEHGGQLMSKTLEHFYISIVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTP 80
Cdd:COG1174    5 LIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  81 AIVALFIYVLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAGG 160
Cdd:COG1174   85 AIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 612908243 161 LGDFIFNGLNLYDPLMIVTATVLVTALALGVDALLALVEKWVVPKGLK 208
Cdd:COG1174  165 LGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPRGLR 212
 
Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-208 1.04e-82

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 244.58  E-value: 1.04e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   1 MIEFLHEHGGQLMSKTLEHFYISIVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTP 80
Cdd:COG1174    5 LIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  81 AIVALFIYVLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAGG 160
Cdd:COG1174   85 AIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 612908243 161 LGDFIFNGLNLYDPLMIVTATVLVTALALGVDALLALVEKWVVPKGLK 208
Cdd:COG1174  165 LGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPRGLR 212
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
26-194 4.85e-21

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 89.38  E-value: 4.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  26 ALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVALFIYVLLPILNNTVLGVQNID 105
Cdd:PRK10952 156 ALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVP 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243 106 SNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAGGLGDFIFNGLNLYDPLMIVTATVLVT 185
Cdd:PRK10952 236 ADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATVGGVGIV 315


                 ....*....
gi 612908243 186 ALALGVDAL 194
Cdd:PRK10952 316 ILAIILDRL 324
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-205 1.69e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 63.09  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   34 AVPIGILL--SKTKRTANIILTVAGVLQTIPTLAVLAIMIP-----IFGVGKTPAIVALFIYVLLPILNNTVLGVQNIDS 106
Cdd:pfam00528   1 GIPLGIIAalRRGRRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  107 NIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAG-GLGDFIFNGLNLYDPLMIVTATVLVT 185
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170       180
                  ....*....|....*....|
gi 612908243  186 ALALGVDALLALVEKWVVPK 205
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDPR 180
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-191 1.23e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.36  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  19 HFYISIVALLLAIIVAVPIGILL-SKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKT---------PAIVALFIY 88
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILaRKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglglPALILALLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  89 VLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAG---GLGDFI 165
Cdd:cd06261   84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGeapGPGTGL 163

                        170       180
                 ....*....|....*....|....*.
gi 612908243 166 FNGLNLYDPLMIVTATVLVTALALGV 191
Cdd:cd06261  164 LLIFAILFPGDLGVAAAVALILLLLS 189
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 10-189 2.68e-09

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 55.24  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   10 GQLMSKTLEHFYISIVALLLAIIVAVPIGIL----LSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVAL 85
Cdd:TIGR01097  54 PRILKALLETLAMAILGTVLAAVLAVPLALLaarnITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLAL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   86 FIYVLlpilnnTVLG------VQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGgirlSSVYV----ISWATLASY 155
Cdd:TIGR01097 134 AFHTV------GFLGklfaeaIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLS----YTLYRfeinVRAAAVLGL 203

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 612908243  156 VGAGGLGDFIFNGLNL--YDPLMIVTATVLVTALAL 189
Cdd:TIGR01097 204 VGAGGIGLELDTAIGLfdYDEVSAIILVILVVVVII 239
 
Name Accession Description Interval E-value
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-208 1.04e-82

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 244.58  E-value: 1.04e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   1 MIEFLHEHGGQLMSKTLEHFYISIVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTP 80
Cdd:COG1174    5 LIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  81 AIVALFIYVLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAGG 160
Cdd:COG1174   85 AIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 612908243 161 LGDFIFNGLNLYDPLMIVTATVLVTALALGVDALLALVEKWVVPKGLK 208
Cdd:COG1174  165 LGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPRGLR 212
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 20-204 5.77e-30

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 111.01  E-value: 5.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  20 FYISIVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVALFIYVLLPILNNTVL 99
Cdd:COG0600   67 LLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243 100 GVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAG-GLGDFIFNGLNLYDPLMIV 178
Cdd:COG0600  147 GVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVVAELLGASsGLGYLILDARQLLDTDLVF 226

                        170       180
                 ....*....|....*....|....*.
gi 612908243 179 TATVLVTALALGVDALLALVEKWVVP 204
Cdd:COG0600  227 AAILVIGLLGLLLDLLLRLLERRLLR 252
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
26-194 4.85e-21

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 89.38  E-value: 4.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  26 ALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVALFIYVLLPILNNTVLGVQNID 105
Cdd:PRK10952 156 ALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVP 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243 106 SNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAGGLGDFIFNGLNLYDPLMIVTATVLVT 185
Cdd:PRK10952 236 ADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATVGGVGIV 315


                 ....*....
gi 612908243 186 ALALGVDAL 194
Cdd:PRK10952 316 ILAIILDRL 324
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 1-187 6.31e-15

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 70.47  E-value: 6.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   1 MIEFLHEHGGQLMSKTLEHFYISIVALLLAIIVAVPIGILLSKTK-------RTANIIL-TVAGVLQTIPTLAVLAIMIP 72
Cdd:COG2011    1 MLTMWSELWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRpggllpnPVLYRVLgVIVNIFRSIPFIILLVALIP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  73 ----IFG--VGKTPAIVALFIYVLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYV 146
Cdd:COG2011   81 ltrlIVGtsIGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 612908243 147 ISWATLASYVGAGGLGDF-IFNGLNLYDPLMIVTATVLVTAL 187
Cdd:COG2011  161 IGYSAMAGAVGGGGLGDLaIRYGYQRFDTDVMLVTVVILIVL 202
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-205 1.69e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 63.09  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   34 AVPIGILL--SKTKRTANIILTVAGVLQTIPTLAVLAIMIP-----IFGVGKTPAIVALFIYVLLPILNNTVLGVQNIDS 106
Cdd:pfam00528   1 GIPLGIIAalRRGRRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  107 NIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAG-GLGDFIFNGLNLYDPLMIVTATVLVT 185
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170       180
                  ....*....|....*....|
gi 612908243  186 ALALGVDALLALVEKWVVPK 205
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDPR 180
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 10-203 5.04e-12

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 62.79  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  10 GQLMSKTLEHFYISIVALLLAIIVAVPIGIL----LSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVAL 85
Cdd:COG3639   47 PDLLSALLETLAIALLGTLLGAVLALPLAFLaarnLAPNPWVRLLARRLLNVLRAIPELVWALIFVAAVGLGPFAGVLAL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  86 FIYvllpilNNTVLG------VQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGgirlSSVYV----ISWATLASY 155
Cdd:COG3639  127 AIH------TIGFLGklfaeaIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFLS----YTLYRfeinIRAATVLGL 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 612908243 156 VGAGGLGDFIFNGLNL--YDPLMIVTATVLVTALAlgVDALLALVEKWVV 203
Cdd:COG3639  197 VGAGGIGLLLNEAIRLfqYDEVAAILLVILVLVLL--IDLLSARLRRRLI 244
PRK10160 PRK10160
taurine ABC transporter permease TauC;
24-152 1.86e-11

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 61.72  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  24 IVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVALFIYVLLPILNNTVLGVQN 103
Cdd:PRK10160  88 VLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMSALAGVKS 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 612908243 104 IDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSsvYVISWATL 152
Cdd:PRK10160 168 AQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIG--LGVGWSTL 214
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
18-200 2.00e-10

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 58.79  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  18 EHFYISIVALLLAIIVAVPIGI---LLSKTKRTANIIL-TVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVALFIYVLLPI 93
Cdd:PRK11365  60 QHLAISSWRALIGFSIGGSLGLilgLISGLSRWGERLLdTSIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  94 LNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSsvYVISWATL--ASYVGA-GGLGDFIFNGLN 170
Cdd:PRK11365 140 YINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRFA--LGLMWLTLivAETISAnSGIGYLAMNARE 217

                        170       180       190
                 ....*....|....*....|....*....|
gi 612908243 171 LYDPLMIVTATVLVTALALGVDALLALVEK 200
Cdd:PRK11365 218 FLQTDVVVVAIILYALLGKLADVSAQLLER 247
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-191 1.23e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.36  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  19 HFYISIVALLLAIIVAVPIGILL-SKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKT---------PAIVALFIY 88
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILaRKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglglPALILALLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  89 VLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVGAG---GLGDFI 165
Cdd:cd06261   84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGeapGPGTGL 163

                        170       180
                 ....*....|....*....|....*.
gi 612908243 166 FNGLNLYDPLMIVTATVLVTALALGV 191
Cdd:cd06261  164 LLIFAILFPGDLGVAAAVALILLLLS 189
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 10-189 2.68e-09

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 55.24  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   10 GQLMSKTLEHFYISIVALLLAIIVAVPIGIL----LSKTKRTANIILTVAGVLQTIPTLAVLAIMIPIFGVGKTPAIVAL 85
Cdd:TIGR01097  54 PRILKALLETLAMAILGTVLAAVLAVPLALLaarnITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLAL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243   86 FIYVLlpilnnTVLG------VQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGgirlSSVYV----ISWATLASY 155
Cdd:TIGR01097 134 AFHTV------GFLGklfaeaIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLS----YTLYRfeinVRAAAVLGL 203

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 612908243  156 VGAGGLGDFIFNGLNL--YDPLMIVTATVLVTALAL 189
Cdd:TIGR01097 204 VGAGGIGLELDTAIGLfdYDEVSAIILVILVVVVII 239
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
12-187 1.25e-06

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 47.42  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  12 LMSKTLEHFYISIVALLLAIIVAVPIGILLSKTK--------RTANIILTVAGVLQTIPTLAVLAIMIP----IFG--VG 77
Cdd:PRK10782   9 LVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRpgqiianaKLYRTLSALVNIFRSIPFIILLVWMIPftrvIVGtsIG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  78 KTPAIVALFIYVLLPILNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVISWATLASYVG 157
Cdd:PRK10782  89 LQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVG 168

                        170       180       190
                 ....*....|....*....|....*....|.
gi 612908243 158 AGGLGDFIFN-GLNLYDPLMIVTATVLVTAL 187
Cdd:PRK10782 169 AGGLGQIGYQyGYIGYNATVMNTVLVLLVIL 199
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
20-147 3.81e-05

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 43.61  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  20 FYISIVALLLAIIVAVPIGILLSKTK-RTANIILTVAGVLQTIPTLaVLAI--------MIPIFGVGKTPAIVALFIYVL 90
Cdd:COG1178  344 LLLALLAALLAVLLALLLAYLVRRRRgRLARLLDRLAMLPYAVPGI-VLGLgllllfnrPLPLLLYGTLAILVLAYVVRF 422

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 612908243  91 LPILNNTVL-GVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVI 147
Cdd:COG1178  423 LPFALRSLEaALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSM 480
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 21-136 5.04e-04

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 39.67  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  21 YISIVALLLAIIVAVPIGIL-LSKTKRTANIILTVAGVLQTIPTLAVLAI---MIPIFGVGKTP---AIVALfiyvllpI 93
Cdd:COG0765   24 LLTVLAIVLGLVLGLLLALArLSPNPVLRWLATAYVEFFRGTPLLVQLFFiyfGLPLLGIDLSPfvaAVIAL-------T 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 612908243  94 LNNTVL-------GVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLIL 136
Cdd:COG0765   97 LNSAAYlaeivraGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIIL 146
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 24-139 1.27e-03

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 39.06  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  24 IVALLLAIIVAVPIGILLSKTKRTANIILTVAGVLQTIPT-----LAVLAIMipIFGVGKTPAIVALFI-----YvllpI 93
Cdd:COG4986  379 VVLIALASLIWVPVGVWIGLRPRLARRLQPVAQFLASFPAnllfpVAVLLIV--RFGLNPNIWLSPLMIlgtqwY----I 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 612908243  94 LNNTVLGVQNIDSNIKEAGKSMGMTQFQLMKDIELPLALP-LILGGI 139
Cdd:COG4986  453 LFNVIAGASAIPNDLREAARNFGLRGWLWWRRLILPGIFPyYVTGAI 499
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
20-148 9.92e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 36.29  E-value: 9.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908243  20 FYISIVALLLAIIVAVPIGILLSKT----KRTANIILTV-------------------AGVLQTIPTLAVLAIMIPIFGV 76
Cdd:COG1178   60 LLLALLVTLLSLLLGVPLAWLLARTdfpgRRLLRWLLLLplalppyvvalawialfgpNGLLNTLLRALFGLEPPDIYGL 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612908243  77 gktPAIVALFIYVLLPILNNTVLGV-QNIDSNIKEAGKSMGMTQFQLMKDIELPLALPLILGGIRLSSVYVIS 148
Cdd:COG1178  140 ---GGIILVLVLFNYPYVYLLLRAAlRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLA 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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