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Conserved domains on  [gi|612908240|gb|EZV19881|]
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hypothetical protein U926_01002 [Staphylococcus aureus 12S00881]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-458 2.50e-62

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 206.64  E-value: 2.50e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  17 IVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIII 96
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  97 TPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLT 176
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 177 LLAMYLIkhapetkaepikgmkaeakkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvgfvyyenk 256
Cdd:cd17321  161 LVALLLA------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 257 ikhplvdfsifknRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPK 336
Cdd:cd17321  168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 337 RPLLLGSGFTVIGLILLSLTFLPEMWYIVssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFG 416
Cdd:cd17321  235 LVLVAGLLLTAVGLLLLALLGADSSVWLL--LPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612908240 417 VAVSGTVYT--------------VLAANLNLNLGGFT-GMMFNALLAIVAFLVILLL 458
Cdd:cd17321  313 VALLGALLTaglsanlgdsgvaaLLSAAAAAFAAGFHlAFLVAAALALLAALLALLL 369
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-458 2.50e-62

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 206.64  E-value: 2.50e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  17 IVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIII 96
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  97 TPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLT 176
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 177 LLAMYLIkhapetkaepikgmkaeakkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvgfvyyenk 256
Cdd:cd17321  161 LVALLLA------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 257 ikhplvdfsifknRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPK 336
Cdd:cd17321  168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 337 RPLLLGSGFTVIGLILLSLTFLPEMWYIVssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFG 416
Cdd:cd17321  235 LVLVAGLLLTAVGLLLLALLGADSSVWLL--LPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612908240 417 VAVSGTVYT--------------VLAANLNLNLGGFT-GMMFNALLAIVAFLVILLL 458
Cdd:cd17321  313 VALLGALLTaglsanlgdsgvaaLLSAAAAAFAAGFHlAFLVAAALALLAALLALLL 369
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-425 1.16e-29

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 120.95  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   13 LLLGIVLGVITFW-LFAQSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVG 90
Cdd:TIGR00711   1 LLLTIVLMLGTFMaVLDSTIVNVAIPtIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   91 SLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFV 170
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  171 VS-----ILLTLLAMYLIKHAPetkaepikgmkAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSP-LILGLIVVFI 244
Cdd:TIGR00711 161 INvpigiIVVVVAFFILPRDKP-----------AASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSnEILILSITGL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  245 CSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIR 324
Cdd:TIGR00711 230 VAIIAFVVWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  325 VGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYiVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGV 404
Cdd:TIGR00711 310 IAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTPDTPF-LAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSL 388

                         410       420
                  ....*....|....*....|.
gi 612908240  405 YKMASSLGNAFGVAVSGTVYT 425
Cdd:TIGR00711 389 SNFTRQLGGSIGTALITTILT 409
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-293 1.53e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 108.74  E-value: 1.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   3 TSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYV 82
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  83 GLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATY 162
Cdd:COG0477   85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 163 IGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLIVV 242
Cdd:COG0477  165 LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612908240 243 FICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVI 293
Cdd:COG0477  245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_1 pfam07690
Major Facilitator Superfamily;
13-416 6.59e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 6.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   13 LLLGIVLGVITFWLFAqslVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSL 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   93 LIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVS 172
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  173 ILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILvvtmlslnviitqtshfgLVSPLILGLIVvficslvgfvy 252
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL------------------LRDPVLWLLLA----------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  253 yenkikhplvdfsifknrgysgatisnFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQ 332
Cdd:pfam07690 209 ---------------------------LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  333 HGPKRPLLLGSGFTVIGLILLSLTFLPemWYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLG 412
Cdd:pfam07690 262 LGRRRRLLLALLLLILAALGLLLLSLT--LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....
gi 612908240  413 NAFG 416
Cdd:pfam07690 340 GALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
56-421 5.51e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 83.24  E-value: 5.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  56 SALFAGLfIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTR-R 134
Cdd:PRK14995  51 SLVMAGM-VLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqR 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 135 QRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTL----LAMYLIKHAPETKAEPIKGMKAeakkfdviglV 210
Cdd:PRK14995 130 NMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLvvmgLTARYVPRQAGRRDQPLNLGHA----------L 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 211 ILVVTMLSLNVIITQTSHFGLVSPLILGLIVVFICSLVGFVYYENKIKHPLVDFSIFKNRgysgATISNFLLNGVAGGAL 290
Cdd:PRK14995 200 MLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHR----IILSGVVMAMTAMITL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 291 IVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKI----LSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVS 366
Cdd:PRK14995 276 VGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIagilVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAW 355

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 367 SIVGYLLFGTGLGLYAtpSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSG 421
Cdd:PRK14995 356 GLMALLGFSAASALLA--STSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFG 408
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-458 2.50e-62

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 206.64  E-value: 2.50e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  17 IVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIII 96
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  97 TPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLT 176
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 177 LLAMYLIkhapetkaepikgmkaeakkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvgfvyyenk 256
Cdd:cd17321  161 LVALLLA------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 257 ikhplvdfsifknRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPK 336
Cdd:cd17321  168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 337 RPLLLGSGFTVIGLILLSLTFLPEMWYIVssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFG 416
Cdd:cd17321  235 LVLVAGLLLTAVGLLLLALLGADSSVWLL--LPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612908240 417 VAVSGTVYT--------------VLAANLNLNLGGFT-GMMFNALLAIVAFLVILLL 458
Cdd:cd17321  313 VALLGALLTaglsanlgdsgvaaLLSAAAAAFAAGFHlAFLVAAALALLAALLALLL 369
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-425 1.16e-29

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 120.95  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   13 LLLGIVLGVITFW-LFAQSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVG 90
Cdd:TIGR00711   1 LLLTIVLMLGTFMaVLDSTIVNVAIPtIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   91 SLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFV 170
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  171 VS-----ILLTLLAMYLIKHAPetkaepikgmkAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSP-LILGLIVVFI 244
Cdd:TIGR00711 161 INvpigiIVVVVAFFILPRDKP-----------AASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSnEILILSITGL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  245 CSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIR 324
Cdd:TIGR00711 230 VAIIAFVVWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  325 VGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYiVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGV 404
Cdd:TIGR00711 310 IAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTPDTPF-LAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSL 388

                         410       420
                  ....*....|....*....|.
gi 612908240  405 YKMASSLGNAFGVAVSGTVYT 425
Cdd:TIGR00711 389 SNFTRQLGGSIGTALITTILT 409
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-293 1.53e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 108.74  E-value: 1.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   3 TSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYV 82
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  83 GLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATY 162
Cdd:COG0477   85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 163 IGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLIVV 242
Cdd:COG0477  165 LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612908240 243 FICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVI 293
Cdd:COG0477  245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 29-459 1.69e-26

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 110.36  E-value: 1.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  29 QSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGR 107
Cdd:cd17503   12 TTIVNVALPtIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 108 IIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIkhap 187
Cdd:cd17503   92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA---- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 188 etkaepikgmkaeakkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvgfvyyenkikhPLVDFSIF 267
Cdd:cd17503  168 ------------------------------------------------------------------------PLLDLRLF 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 268 KNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLlgSGFTV 347
Cdd:cd17503  176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL--AGLLL 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 348 IGLILLSLTFLPEMWYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTV- 426
Cdd:cd17503  254 LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNr 333

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 612908240 427 ----------LAANLNLNLGGFTGMMFNALLAIVAFLVILLLV 459
Cdd:cd17503  334 tqfhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLLA 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-414 3.56e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.91  E-value: 3.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVG 90
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPlIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  91 SLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFV 170
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 171 VSILLTLLAMYLI-KHAPETKAEPIKGMKAEAKkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvg 249
Cdd:COG2814  169 VNAVLALLALLLLlRLLPESRPAARARLRGSLR----------------------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 250 fvyyenkikhplvdfSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKI 329
Cdd:COG2814  202 ---------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 330 LSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWyivssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMAS 409
Cdd:COG2814  267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL-----LLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341


                 ....*
gi 612908240 410 SLGNA 414
Cdd:COG2814  342 FLGGP 346
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 34-459 4.08e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 103.42  E-value: 4.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  34 LVVPLQSTYSSDVG----TINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRII 109
Cdd:cd17325   14 IIIPILPLYAESLGasvaQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 110 QGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17325   94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 190 KAEPIKGMKAEAKKFDVIGLVIlvvtmlslnviitqtshfgLVSPLILGLIVVFicslvgfvyyenkikhplvdfsifkn 269
Cdd:cd17325  174 PRPPPNKRAVSAARLRSGLRLL-------------------LRDRRLLALFLAI-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 270 rgysgatisnFLLNGVAGGALIVINTYYQQQLGFNSSQTGYI-SLTYLIAVLSMIRVGeKILSQHGPKRPLLLgsGFTVI 348
Cdd:cd17325  209 ----------FVLAFAFGALEPFLPLYAAELGGLSPAQIGLLfGAQGLASALSQPPAG-KLSDRIGRKPLILI--GLLLS 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 349 GLILLSLTFLPEMWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVla 428
Cdd:cd17325  276 AVALLLLPLATSFWLL---LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-- 350

                        410       420       430
                 ....*....|....*....|....*....|.
gi 612908240 429 anlnlnLGGFTGMMFNALLAIVAFLVILLLV 459
Cdd:cd17325  351 ------FGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
13-416 6.59e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 6.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   13 LLLGIVLGVITFWLFAqslVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSL 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   93 LIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVS 172
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  173 ILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILvvtmlslnviitqtshfgLVSPLILGLIVvficslvgfvy 252
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL------------------LRDPVLWLLLA----------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  253 yenkikhplvdfsifknrgysgatisnFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQ 332
Cdd:pfam07690 209 ---------------------------LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  333 HGPKRPLLLGSGFTVIGLILLSLTFLPemWYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLG 412
Cdd:pfam07690 262 LGRRRRLLLALLLLILAALGLLLLSLT--LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....
gi 612908240  413 NAFG 416
Cdd:pfam07690 340 GALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-461 3.03e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 86.08  E-value: 3.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVV 171
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 172 SIlltllamylikhapetkaepikgmkaeakkfdVIGLVILVVTMLslnviitqtshfglvsplilglivvficslvgfv 251
Cdd:COG2271  170 LG--------------------------------LPGLLLALLRFW---------------------------------- 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 252 yyenkikhplvdfsifknrgysGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILS 331
Cdd:COG2271  184 ----------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 332 QHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSL 411
Cdd:COG2271  242 RLGRRRKLVLAIGLLLAALALLLLALLPSPALA---IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL 318

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 612908240 412 GNAFGVAVSGTVYTvlaanlnlNLGGFTGMMFNALLAIVAFLVILLLVPK 461
Cdd:COG2271  319 GGALGPLLVGYLLD--------ATGYQAAFLLLAALALLAALLALLLLRE 360
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 48-251 6.19e-18

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 85.32  E-value: 6.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  48 TINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINE 127
Cdd:cd17473   36 LVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 128 YYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATyIGWRSIF---VVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKF 204
Cdd:cd17473  116 YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFlvyLLALPVLILVLLFLPEPARKSKSAASPGAATAAAL 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 205 D----VIGLVILVVTMLSLNVIITQTS----HFGLVSPLILGLIVVFIcSLVGFV 251
Cdd:cd17473  195 PwkrvLPIYFLAFLAMLLFYVIPIQLPfllqERGGGSAALIGLALAIA-SLAGAI 248
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 18-455 4.51e-17

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 82.62  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  18 VLGVITFWLFAQSLVNLVVP----LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLL 93
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPalpaIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  94 IIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVV-S 172
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFlA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 173 ILLTLLAMYLIKHAPETKaepikgmKAEAKKFDVIGLVILVVTMLSlnviitqtshfglvSPLILGLIVVFICSLVGFvy 252
Cdd:cd17320  161 LLGLLLLLLVLLFLPETL-------PEEKRKPLLSSLLRAYKRVLK--------------NRRFLGYALALGLSFAGL-- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 253 yenkikhplvdfsifknrgYSGATISNFLlngvaggalivintyYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQ 332
Cdd:cd17320  218 -------------------FAYLAAAPFI---------------YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRR 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 333 HGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVSSIVGYLLFGTGLGLyATPSTDTAVASAPDDKSGVASGVYKMASSLG 412
Cdd:cd17320  264 FGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGL-IFPNATSLALEPFPHVAGTASALLGFLQFLI 342

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 612908240 413 NAFGVAVSGTVYTVLAANLNLnlggftGMMFNALLAIVAFLVI 455
Cdd:cd17320  343 GALAGALVGLLPNGTALPMGL------LILVLGLLALLLLILL 379
PRK14995 PRK14995
SmvA family efflux MFS transporter;
56-421 5.51e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 83.24  E-value: 5.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  56 SALFAGLfIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTR-R 134
Cdd:PRK14995  51 SLVMAGM-VLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqR 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 135 QRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTL----LAMYLIKHAPETKAEPIKGMKAeakkfdviglV 210
Cdd:PRK14995 130 NMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLvvmgLTARYVPRQAGRRDQPLNLGHA----------L 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 211 ILVVTMLSLNVIITQTSHFGLVSPLILGLIVVFICSLVGFVYYENKIKHPLVDFSIFKNRgysgATISNFLLNGVAGGAL 290
Cdd:PRK14995 200 MLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHR----IILSGVVMAMTAMITL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 291 IVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKI----LSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVS 366
Cdd:PRK14995 276 VGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIagilVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAW 355

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 367 SIVGYLLFGTGLGLYAtpSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSG 421
Cdd:PRK14995 356 GLMALLGFSAASALLA--STSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFG 408
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 34-459 2.99e-16

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 79.93  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  34 LVVPLQSTYSSDVGTINIAVSLSA----LFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRII 109
Cdd:cd17504   14 MLSPALPTIQREFGTSAAAVSWVLtaylLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 110 QGLSAAcIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIkhapet 189
Cdd:cd17504   94 QGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV------ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 190 kaepikgmkaeakkfdviglvilvvtmlslnviitqtshfglvsplilglivvficslvgfvyyenkikhPLVDFSIFKN 269
Cdd:cd17504  167 ----------------------------------------------------------------------PLIDLRLLRR 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 270 RGYSGATISNFLLNGVAGGALIVINTYYQQQ----LGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGF 345
Cdd:cd17504  177 RNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 346 TVIGLILLsLTFLPEMWYIVssiVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYT 425
Cdd:cd17504  257 SAVGLLLL-ALLHSSLWALV---VALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332

                        410       420       430
                 ....*....|....*....|....*....|....
gi 612908240 426 VLAANLNLNLGGFTGMMFNALLAIVAFLVILLLV 459
Cdd:cd17504  333 TYTVSITSGGVPTEGAYVLAFLIGAALALAALLL 366
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 49-458 1.67e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 74.55  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  49 INIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEY 128
Cdd:cd17489   33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 129 YIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIg 208
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRL- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 209 lvilvvtmlslnviitqtshfglVSPLIlgLIVVFICSLVGFVYyenkikhplvdfsifknrgysgATISNFllngvagg 288
Cdd:cd17489  192 -----------------------VEKKV--LPPALILFLASIAY----------------------GAISTF-------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 289 alivINTYYQQQlgfNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLtflpeMWYIVSSI 368
Cdd:cd17489  217 ----LPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF-----AGSPWMLL 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 369 VGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVLaanlnlnlgGFTGMMFNALLA 448
Cdd:cd17489  285 LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF---------GYRAMFLLAAVV 355

                        410
                 ....*....|
gi 612908240 449 IVAFLVILLL 458
Cdd:cd17489  356 VLLALVLYIF 365
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-456 4.40e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 70.27  E-value: 4.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  37 PLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAAC 116
Cdd:cd17324   24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 117 IMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIkhapetkaepIKG 196
Cdd:cd17324  104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLL----------WRL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 197 MKAEAKKFDVIGLVILVVTMLslnviitqtshfglvsplilglivvficslvgfvyyenkikhplvdfsiFKNRGYSGAT 276
Cdd:cd17324  174 LPSLPPKKPGSLGLLSSLLLL-------------------------------------------------LRNPRLRLAY 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 277 ISNFLLNGVAGGALIVINTYYQQQLGFNSSQ-TGYISLTYLIAVLSMIRVGekILSQHGPKRPLLLGSGFTVIGLILlsL 355
Cdd:cd17324  205 LITFLLFGGFFALYTYLAPFLTDVPGFSSSAiIGLLLLFGVAGVVGSPLAG--RLADRGGRRALLIALLLLAAALLL--L 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 356 TFLPEMWYIVssIVGYLLFGTGLGLYATPSTDTAVASAPDDKsGVASGVYKMASSLGNAFGVAVSGTVYTvlaanlnlnL 435
Cdd:cd17324  281 TLLGPSPLLL--LVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLD---------H 348

                        410       420
                 ....*....|....*....|..
gi 612908240 436 GGFTGM-MFNALLAIVAFLVIL 456
Cdd:cd17324  349 GGWAGVgWVGAALLLLALLLAL 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 68-429 5.48e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 69.90  E-value: 5.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  68 GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSiGSWG 147
Cdd:cd17502   51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIG-AVFG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 148 GSGIC-TLFGGLMATYIGWRSIFVVSILLTLLAMYLIkhapetkaepikgmkaeakkfdviglvilvvtmlslnviitqt 226
Cdd:cd17502  130 IASVAgPLIGGAFTDHLSWRWCFYINLPIGGLALALL------------------------------------------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 227 shfglvsplilglivvficslvgfvyyenkikhplvdfsifknRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSS 306
Cdd:cd17502  167 -------------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSAT 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 307 QTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVssIVGYL-LFGTGLGLYATPS 385
Cdd:cd17502  204 KSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWL--LIGYLiLLGLGLGIGFQQP 281

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 612908240 386 TDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVLAA 429
Cdd:cd17502  282 LVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLVALAL 325
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 48-425 6.32e-13

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 70.73  E-value: 6.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  48 TINIAVSLSALFAGLfivgagdVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACImPSTLAIINE 127
Cdd:cd06179   40 AWSLAQAVLGPIVGR-------LSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 128 YYIGTRRQRALSYWSIGSWGGSGICTLFGGLM--ATYIGWRSIFVVSIL---LTLLAMYLIKHAPETKAEPIKGMKAEAK 202
Cdd:cd06179  112 LVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIfnaLALILLFFFYHPPPRPQLHGSSTRQKLK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 203 KFDVIGLVILVVTMLSLNVIITQT-SHFGLVSPLILGLIVVFICSLVGFVYYENK--IKHPLVDFSIFKNRGYSGATIsn 279
Cdd:cd06179  192 RLDWVGLFLLIAGLVLFLLGLSWGgNPYPWSSAHVIAPLVIGGVLLIAFGLYEWKgtKDGLLPPRLLFRGRNFALILI-- 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 280 flLNGVAGGALIVINTYYQQQLGF----NSSQTGYISLT-YLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLS 354
Cdd:cd06179  270 --VAFVEGMIFYSLNIFWPQQISLlfttDPLKAGLYQLPfGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLA 347

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612908240 355 LTfLPEMwyiVSSIVGYLLF-GTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYT 425
Cdd:cd06179  348 LI-TPDN---KALAIAFSVLaGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSILS 415
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 60-459 1.56e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 65.67  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  60 AGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALS 139
Cdd:cd17474   47 AAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 140 YWSIGSWGGSGICTLFGGLMATyIGWRSIFV---VSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVtm 216
Cdd:cd17474  127 LYEAALGLGIAVGPLLGGLLAA-ISWRYPFFllaALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTF-- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 217 lslnviitqtshfglvsplilgLIVVFICSLVGFVYyenkikhpLVDFSIFKNRGYSGATISNFLLNGVAGGALIVInty 296
Cdd:cd17474  204 ----------------------LVSAFLYFFLYFAF--------LTYLPFLLELLYGISPIIIGLLFAGWSVLLALG--- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 297 yqqqlgfnSSQTGYISltyliavlsmirvGEKILSQHgpkrplLLGSGFTVIGLILLSLTFLPEMWYIVSSIVgylLFGT 376
Cdd:cd17474  251 --------SLFVGRLL-------------KKRFGARR------ILVIGLLLYALSLLLLGFVPSLALLLIAIV---LFGL 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 377 GLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTvlaanlnlnLGGFTGMMFNALLAIVAFLVIL 456
Cdd:cd17474  301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE---------IFGLSAPFLVGAAIALAAAVLL 371


                 ...
gi 612908240 457 LLV 459
Cdd:cd17474  372 ALL 374
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 44-436 2.32e-11

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 65.79  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  44 SDVGTINIAVSLSALFAGLFIVGAGDVadkFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIM----- 118
Cdd:cd17322   37 SLLSTINVVNNIVSAVSQPPYAKLSDV---FGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNllltl 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 119 -----------------PSTLAIINEYYIGTRRQRAL--SYWSigsWGgsgictlfgglmatYIGWRSIF-VVSILLTLL 178
Cdd:cd17322  114 iladfsslknrgfasaiPSLPYIITTWIGGNIAQAALpnSNWR---WG--------------YGMWAIILpLSSLPLVLC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 179 AMY---------LIKHAPETKAEPIKGMKAEA-----KKFDVIGLVILVVTMLSLNVIITQTSHF--GLVSPLILGLIVV 242
Cdd:cd17322  177 LLYmqrkarkdgEIKELKNQETEEQTGGLSQNlvklfWKLDIFGVILLTAGLGLILVPLTLAGGAksKWKNSSIIAMIVL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 243 FICSLVGFVYYENKI-KHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIA-VL 320
Cdd:cd17322  257 GGVLLVAFLLWEAKFaKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVsTV 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 321 SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLsLTFLPEMWYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV 400
Cdd:cd17322  337 AGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLL-IRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAV 415

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 612908240 401 ASGVYKMASSLGNAFGVAVSGTVYT-VLAANLNLNLG 436
Cdd:cd17322  416 VTALLLTVYSIGGAVGAAISGAIWTqTLPKKLLKNLP 452
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
12-458 3.62e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.52  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIF-- 169
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFli 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 170 --VVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKfdviglvilvvtmlslnviitqtshfGLVSPLILGLIVVFICSL 247
Cdd:COG2223  165 lgILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE--------------------------ALRDPRFWLLSLLYFGTF 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 248 VGFVyyenkikhplvdfsifknrgysgaTISNFLLngvaggalivinTYYQQQLGFNSSQTGYI-SLTYLIAVLSMIrVG 326
Cdd:COG2223  219 GSFI------------------------GFSSWLP------------PYLVDQFGLSAATAGLLaALFALLGALGRP-LG 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 327 EKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVSSIVGYLLFGTGLGLYATpstdTAVASAPDDKSGVASGVYK 406
Cdd:COG2223  262 GWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA----LVPDIFPTKNAGAVYGLVG 337

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 612908240 407 MASSLGNAFGVAVSGTVYTVlaanlnlnLGGFT-GMMFNALLAIVAFLVILLL 458
Cdd:COG2223  338 AAGGLGGFLGPLLFGALLDA--------TGSYTaAFLVFAVLALVALVLTLLL 382
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 38-184 8.21e-11

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.39  E-value: 8.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  38 LQSTYSSDVGTINIAVSLSALFAGLFI--VGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAA 115
Cdd:cd17316   25 LAAEFSLGLSLLQTGLLFAAGFLGRPIgaLLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIG 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612908240 116 CIMPSTLAIINEYYIGTRRQRALSY----WSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIK 184
Cdd:cd17316  105 GEYPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRR 177
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 17-456 2.98e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.67  E-value: 2.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  17 IVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIII 96
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  97 TPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYI--GWRSIFVVSIL 174
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 175 LTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVilvvtmlslnviitqtshfglvsplilglivvficslvgfvyye 254
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 255 nkikhplvdFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHG 334
Cdd:cd06174  197 ---------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 335 PKRPLLLGSGFtvigLILLSLTFLPEMWYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNA 414
Cdd:cd06174  268 GRKPLLLIGLL----LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGA 343

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 612908240 415 FGVAVSGTVytvlaanLNLNLGGFTGMMFNALLAIVAFLVIL 456
Cdd:cd06174  344 IGPLLAGFL-------LAATFGLTGAFLVLAVLLLLAAILLL 378
PRK10504 PRK10504
putative transporter; Provisional
 67-421 8.89e-10

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 60.52  E-value: 8.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  67 AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSW 146
Cdd:PRK10504  65 SGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQ 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 147 GGSGICTLFGGLMATYIGWRSIFVVSI-------LLTLLAMylikhapetkaepiKGMKAEAKKFDVIGLVILVVTMLSL 219
Cdd:PRK10504 145 VGPLLGPALGGLLVEYASWHWIFLINIpvgiigaIATLMLM--------------PNYTMQTRRFDLSGFLLLAVGMATL 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 220 NVIITQTSHFGLVSPLILGLIVVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQ 299
Cdd:PRK10504 211 TLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQI 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 300 QLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLgsgfTVIGLILLSLTFLPEM---WYIVSSIVGYLLFGT 376
Cdd:PRK10504 291 GLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA----TTLGLALVSLLFMLVAllgWYYLLPFVLFLQGMV 366

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 612908240 377 GLGLYATPSTDTaVASAPDDKSGVASGVYKMASSLGNAFGVAVSG 421
Cdd:PRK10504 367 NSTRFSSMNTLT-LKDLPDNLASSGNSLLSMIMQLSMSIGVTIAG 410
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 57-169 7.60e-09

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 57.27  E-value: 7.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  57 ALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYY-IGTRRQ 135
Cdd:cd17476   43 SLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKN 122

                         90       100       110
                 ....*....|....*....|....*....|....
gi 612908240 136 RALSYWSIGSWGGSGICTLFGGLMATYIGWRSIF 169
Cdd:cd17476  123 IVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
204-460 2.43e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 2.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 204 FDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLIVVFICSLVGFV-----YYENKIKHPLVDF--SIFKNRGYSGAT 276
Cdd:COG2211  155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFgtkerPVPEEEKVSLKESlkALLKNRPFLLLL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 277 ISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLT 356
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 357 FLPEMWYIvssIVGYLLFGTGLGLYaTPSTDTAVASAPD--------DKSGVASGVYKMASSLGNAFGVAVSGTVytvla 428
Cdd:COG2211  315 GPGNLWLL---LVLAALAGIGLGAI-LVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLL----- 385

                        250       260       270
                 ....*....|....*....|....*....|..
gi 612908240 429 anlnLNLGGFTGMMFNALLAIVAFLVILLLVP 460
Cdd:COG2211  386 ----LALFGYVAGAAQSPSALTGIRLLFFLLP 413
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 55-188 6.79e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 54.28  E-value: 6.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   55 LSALFAGLFIvgaGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRR 134
Cdd:TIGR00895  63 IGMAFGALFF---GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240  135 QRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTL-LAMYLIKHAPE 188
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLlLLLLLMRFLPE 194
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 21-286 7.67e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 54.15  E-value: 7.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  21 VITFWLFAQSLVnlvVPLQSTYSSDVGtiniavsLSALFAGLfIVGA------------GDVADKFGRVKI-TYVGLILN 87
Cdd:cd17490    4 IVFLFWFSQYVY---VPFLSPYAESLG-------ASLSMIGI-ILGAygisqmllriplGILSDRIGKRKLfIIIGLLFT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  88 VVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINeYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRS 167
Cdd:cd17490   73 VLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 168 IFVVSILLTLLAMYLIKHAPETKAEP------IKGMKAEAKKFDVIGLVILVVTMLSLNVIITQT------SHFGLVSPL 235
Cdd:cd17490  152 PFLLAALAGVLGFILSLFIKEERREKkpvlteLKELLSVLKDKKLLFFSLLAILQQMITFSTTFGftpliaKQLGASSFQ 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612908240 236 ILGLIVVFICSLVGFVYyenkikhpLVDFSIFKNRGYSGATISNFLLNGVA 286
Cdd:cd17490  232 LGLLSIIYLLPNALASL--------LSGTLFYKKLGERNTIIIGFLLLGAY 274
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 38-169 1.43e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 53.35  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  38 LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACI 117
Cdd:cd17323   25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 612908240 118 MPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIF 169
Cdd:cd17323  105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 34-189 2.01e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.07  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  34 LVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLS 113
Cdd:cd17371   21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 114 AACIMPSTLAIINEYYIGTRRQRALSY----WSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17371  101 FGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEP 180
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 12-453 3.82e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.23  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTySSDVGTINIAVSLSALFAGLFivgAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGS-ALLVGLVLAAFFLPFLLFSPF---AGVLADRFDRRRLLILADLLRALLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITPL-----PAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWR 166
Cdd:cd06173   79 AVLALLALlgslsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 167 SIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIitqtshfglvsplilglivvfics 246
Cdd:cd06173  159 GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLL------------------------ 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 247 lvgfvyyenkikhplvdfsifknrgysgatISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVG 326
Cdd:cd06173  215 ------------------------------LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLL 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 327 EKILSQHGPKRplLLGSGFTVIGLILLSLTFLPEMWYivsSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYK 406
Cdd:cd06173  265 GRLSKRRRRGR--LLLIGALLLGLALLVLGLSPSLWL---LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 612908240 407 MASSLGNAFGVAVSGtvytVLAANLNLNLGGFTGMMFNALLAIVAFL 453
Cdd:cd06173  340 ALNSGAMPLGALLAG----LLADALGLSAVFLLAGALLLLAALLLLL 382
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 21-321 5.71e-07

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 51.98  E-value: 5.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   21 VITFWLFAQSLVNLVVPLQSTYSS------DVGTiniaVSLSALFAGLFIVGA-------GDVADKFGRVKITYVGLILN 87
Cdd:pfam06609  43 IASFAAFSLNVCATYFVLQASASAlpnilqDIGQ----SENQGLFSTLWTMGQavsilmmGRLTDRFGRRPFVIATHIIG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   88 VVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLaIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRS 167
Cdd:pfam06609 119 LVGAIVGCTANKFNTLLAAMTLLGVAAGPAGASPL-FIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRW 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  168 IFVVSILLTLLAMYLI---KHAPETKAepIKGMKA----EAKKFDVIG--LVILVVTMLSLNVIITQTSHFGLVSPLILG 238
Cdd:pfam06609 198 IFYIYIIMSAIAVLLIiiwYHPPSFAQ--LHGKKArkrdELAKLDWIGifLVIAGTSLFLLGVSWGGKPNNPWNSAKIIG 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  239 LIVVFICSLVGFVYYE--NKIKHPLVDFSIFKN-RGYsgatISNFLLNGVAGGALIVINTYYQQQLG--FNSSQTGYISL 313
Cdd:pfam06609 276 LISSGAGSLVIFALYEvfGKPEQPIIPPALFKDtRGF----VCILIISSIMGAMHLCLTIIYPQQVIniFGSSLKNWEET 351


                  ....*...
gi 612908240  314 TYLIAVLS 321
Cdd:pfam06609 352 AWMSATAS 359
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
13-180 5.76e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.41  E-value: 5.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  13 LLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSL 92
Cdd:COG2807   19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  93 LIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYiGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVS 172
Cdd:COG2807   99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177


                 ....*...
gi 612908240 173 ILLTLLAM 180
Cdd:COG2807  178 ALLALLAL 185
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
281-460 6.51e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 6.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 281 LLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPE 360
Cdd:COG2814   20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 361 MWyivssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVlaanlnlnLGGFTG 440
Cdd:COG2814  100 LL-----LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL--------FGWRWV 166

                        170       180
                 ....*....|....*....|
gi 612908240 441 MMFNALLAIVAFLVILLLVP 460
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLP 186
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 67-180 8.16e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.05  E-value: 8.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  67 AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSW 146
Cdd:cd17365   54 AGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYP 133

                         90       100       110
                 ....*....|....*....|....*....|....
gi 612908240 147 GGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM 180
Cdd:cd17365  134 LGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL 167
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 35-178 9.48e-07

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 50.63  E-value: 9.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  35 VVPLQSTY---SSDVGTIniavsLSALFAGLFI--VGAGDVADKFGRVKItyvgLILNVVG-SLLIIITPLPA-----FL 103
Cdd:cd17380   22 IVPMAKEFgwsKTDQGLV-----LSSFFWGYALtqVLGGYLADRFGGKKV----LLLAVALwSLATLLTPLLAysslpLL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 104 IIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLL 178
Cdd:cd17380   93 ILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLL 167
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 44-180 1.34e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  44 SDVGTINIAVSLSALFAGLFivgAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLA 123
Cdd:cd17489  227 SNAGLFFTVYAIALLLSRPF---SGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612908240 124 IINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM 180
Cdd:cd17489  304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 45-250 2.05e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 50.08  E-value: 2.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  45 DVGTINIAVSLSALF-----AGLFIvgaGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMP 119
Cdd:PRK03893  51 GLTTVQAASLISAAFisrwfGGLLL---GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 120 STLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPETK--AEPIKGM 197
Cdd:PRK03893 128 SSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEdwKEKHAGK 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612908240 198 KAEAKKFDV--------IGLVILVVTMLSLNVIITQTSHFGLVSpLILGLIV--VFICSLVGF 250
Cdd:PRK03893 208 APVRTMVDIlyrgehriINILLTLAAAAALWFCFAGNLQNAAIV-AVLGLLCaaIFISFMVQS 269
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-149 2.38e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.59  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   5 KQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGL 84
Cdd:COG2814  201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612908240  85 ILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGS 149
Cdd:COG2814  281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 12-180 2.85e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.19  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:cd17355    3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITP-LPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFV 170
Cdd:cd17355   83 VLLALATsLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162

                        170
                 ....*....|
gi 612908240 171 VSILLTLLAM 180
Cdd:cd17355  163 VLALLALLVL 172
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
51-195 4.52e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 48.74  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  51 IAVSLSALFAGlFIVGA---GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGL---SAACIMPstlAI 124
Cdd:PRK11043  43 VSASLSLFLAG-FALGQllwGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgvcSAAVIWQ---AL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 125 INEYYIGTRRQR---------ALSywsigswggSGICTLFGGLMATYIGWRSIFVV----SILLTLLAMYLIKHAPETKA 191
Cdd:PRK11043 119 VIDRYPAQKANRvfatimplvALS---------PALAPLLGAWLLNHFGWQAIFATlfaiTLLLILPTLRLKPSKKARKQ 189


                 ....
gi 612908240 192 EPIK 195
Cdd:PRK11043 190 SQDA 193
emrD PRK11652
multidrug transporter EmrD;
68-189 7.09e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 47.98  E-value: 7.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  68 GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAAC--IMPSTLAiiNEYYIGTRRQRALSYWSIGS 145
Cdd:PRK11652  64 GPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVggVMARTLP--RDLYEGTQLRHANSLLNMGI 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 612908240 146 WGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLI-KHAPET 189
Cdd:PRK11652 142 LVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMaRWMPET 186
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 68-191 7.58e-06

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 48.06  E-value: 7.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  68 GDVADKFGRVKITYVGLILNVVGSLLIIITP--------LPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALS 139
Cdd:cd17367   61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPtyatigiwAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612908240 140 YWSIGSWGGSgICTLFGGLMATYI---------GWRSIFVVSILLTLLAMYLIKHAPETKA 191
Cdd:cd17367  141 FQYVTLIGGQ-LLALGVLLVLQHTlgedqmaawGWRIPFLLGGVLAVVVLWLRRGLEETES 200
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 10-183 7.76e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 7.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  10 DNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGD-VADKFGRVKITYVGLILNV 88
Cdd:cd17474  197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  89 VGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSI 168
Cdd:cd17474  277 LSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356

                        170
                 ....*....|....*
gi 612908240 169 FVVSILLTLLAMYLI 183
Cdd:cd17474  357 FLVGAAIALAAAVLL 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
11-219 7.84e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  11 NRLLLGIVLGVITFWLFAQSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVV 89
Cdd:COG0738    6 YRRALIAIYLLFFLWGFATALWGPLIPaLKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  90 GSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQR---ALSYWSIGSWGGSGICTLFGGLMATyIGWR 166
Cdd:COG0738   86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRlnlLHAFFSLGALLGPLLGGLLILLGLS-LSWH 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 167 SIFVVSILLTLLAMYLIK--HAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSL 219
Cdd:COG0738  165 LPYLILAVLLLLLALLFLrsKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAI 219
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 34-195 8.91e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.60  E-value: 8.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  34 LVVPLQSTYSSDVGT-----INIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRI 108
Cdd:cd17472   14 LVLPVLSVYAKSLPGatptlIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 109 IQGLSAacIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM----YLIK 184
Cdd:cd17472   94 LQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLlillFFVP 171

                        170
                 ....*....|.
gi 612908240 185 HAPETKAEPIK 195
Cdd:cd17472  172 DPPKIVQISEK 182
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 52-182 9.21e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.58  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  52 AVSLSALFAGLFIVG--AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYY 129
Cdd:cd17317   28 ALVQTIFFLGVLIGSllFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 612908240 130 IGTRRQRALSY----WSIGswggsgicTLFGGLMATYIG-WRSI-FVVSILLTLLAMYL 182
Cdd:cd17317  108 GPKYRSFVGILfglfWALG--------YMLLALLAYLIRdWRWLqLAISLPGLLFLLLL 158
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-182 9.27e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.54  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  51 IAVSLSALFAGLFIVG---AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINE 127
Cdd:COG0738  247 TAALGLSLFWGGMTIGrflGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612908240 128 yYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYL 182
Cdd:COG0738  327 -GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 55-178 2.85e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 46.07  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  55 LSALFAGLFI--VGAGDVADKFGRVKITYVGLILNvvgSLLIIITPLPA-----FLIIGRIIQGLSAACIMPSTLAIINE 127
Cdd:cd17318   62 LSSFFYGYILtqIPGGYLAEKYGAKRVLGYSILIT---ALLTLLTPLAArggygALIVLRILQGLAQGVTFPAMHALWAK 138

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612908240 128 YYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLL 178
Cdd:cd17318  139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLL 189
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 57-183 3.69e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.69  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  57 ALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQR 136
Cdd:cd17328   44 IISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 612908240 137 ALSYWSIGSWGGSGICTLFGGLMATYI-GWRSIFVVSILLTLLAMYLI 183
Cdd:cd17328  124 ALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILL 171
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 11-179 4.05e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.68  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  11 NRLLLGIVLGVITFWLFAQSLVNLVVPLQSTY----SSDVGTINIAVSLSALFAGLFivgAGDVADKFGRVKITYVGLIL 86
Cdd:cd06173  207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVlgggAAGYGLLLAAFGVGALLGALL---LGRLSKRRRRGRLLLIGALL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  87 NVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWR 166
Cdd:cd06173  284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363

                        170
                 ....*....|...
gi 612908240 167 SIFVVSILLTLLA 179
Cdd:cd06173  364 AVFLLAGALLLLA 376
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 55-458 7.79e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.87  E-value: 7.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  55 LSALFAGLFIVG--AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGT 132
Cdd:cd17319   44 ASAFFLGYALFQvpGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 133 RRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVsilltllamylikhapetkaepikgmkaeakkfdviglvil 212
Cdd:cd17319  124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII----------------------------------------- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 213 vvtmlslnviitqtshFGLVSPLILGLIVVFICSLVGFVyyenkikhplvdfsifknrgysgatISNFLLNGVAGGALIV 292
Cdd:cd17319  163 ----------------EGLLGLLLAVLWWFYLRQVWGLA-------------------------LGYFGINYALYGLLTW 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 293 INTYYQQQLGFNSSQTGYI-SLTYLIAVLSMIRVG--EKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVSSIV 369
Cdd:cd17319  202 LPTYLKQARGFSLKQVGLLaAIPFLAGAIGMILGGrlSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 370 GYLLFGTGLGLYATPSTdtavaSAPDDKSGVASGVYKMASSLGNAFGVAVSGTVytvlaanLNLNLGGFTGMMFNALLAI 449
Cdd:cd17319  282 GFGIGAASPVFWSLPAD-----LLPGEAAATAGGLINSGGNLGGFVAPLLIGYL-------VDATGSYTAAFLFLAAVAL 349


                 ....*....
gi 612908240 450 VAFLVILLL 458
Cdd:cd17319  350 LAALLVLLL 358
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 318-458 9.78e-05

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 44.41  E-value: 9.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 318 AVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLT-FLPEMWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDD 396
Cdd:cd06176  272 TLLGMLLAGFLLSRRLGKKRTAALGCLLSALGFLLLALAgLLGNPWLF---RPGVFLLGLGNGLFTVGALTLMMDLTGEG 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612908240 397 KSGVASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFtGMMFnaLLAIVAFLVILLL 458
Cdd:cd06176  349 TAGLFMGLWGAAQALARGLGTLLGGALRDLLRALFGSPALAY-GLVF--LLEAVLLLVALLL 407
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 280-461 1.27e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.10  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 280 FLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLP 359
Cdd:cd17325    5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 360 EMWyivssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVlaanlnlnLGGFT 439
Cdd:cd17325   85 WQL-----LLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRA 151

                        170       180
                 ....*....|....*....|..
gi 612908240 440 GMMFNALLAIVAFLVILLLVPK 461
Cdd:cd17325  152 PFLVCAALALLALVLALLLLPE 173
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 27-243 1.42e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  27 FAQSLVNLVVP-LQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLII 105
Cdd:cd17478   10 FYQGFLPALLPlLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 106 GRIIQGLSAACIMPSTLAIINEYYiGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKH 185
Cdd:cd17478   90 LVALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 612908240 186 APETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLIVVF 243
Cdd:cd17478  169 LRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG 226
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-191 2.29e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  17 IVLGVITFWLFAQSLVNLVVPLQSTYS--SDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLI 94
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVlgLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  95 IITPL--PAFLIIGRIIQGLSAACIMPSTLAII------NEYYIGTRRQ-RALSYWSIGSWGGSGICTLFGGLMATYIGW 165
Cdd:COG2211  312 FFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTGRRREgLYFGIFTFAIKLGQALAGALAGLLLALFGY 391

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 612908240 166 RS---------------IFVVSILLTLLAMYLIKHAPETKA 191
Cdd:COG2211  392 VAgaaqspsaltgirllFFLLPAVLLLLAALLLLFYPLTRE 432
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 34-457 2.31e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  34 LVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGA-------GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIG 106
Cdd:cd17330   14 IVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQflasplwGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 107 RIIQGLSAACIMPSTLAIineYYIGTRRQRALSYWSIG-SWGGSGICT-LFGGLMATYIGWRSIFVVSILLTLLAMYLIK 184
Cdd:cd17330   94 RFLDGLTGGNVSVAQAYI---ADITDEEERAKAFGIISaAFGLGFILGpALGGFLSTPYGYALPFLVAAALALLNLVLVL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 185 HapetkaepikgmkaeakkfdviglvilvvtmlslnviitqtshfgLVSPLILGLIVVFICSLVGFVYYEnkikhplvdf 264
Cdd:cd17330  171 F---------------------------------------------FLPPLRRLLLVYFLIALAFAGLES---------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 265 sifknrgysgaTISNFLLngvaggalivintyyqQQLGFNSSQTGY-ISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGS 343
Cdd:cd17330  196 -----------VFSLFLK----------------DRFGFSPSQIGLlLALVGIAGILAQLLLIPRLAKRLGERKLLRLGL 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 344 GFTVIGLILLSLtflpeMWYIVSSIVGYLLFGTGLGLyATPSTDTAVA-SAPDDKSGVASGVYKMASSLGNAFGVAVSGT 422
Cdd:cd17330  249 LLAIIGLLLLPF-----ASSVPLLVLAAAILAFGTGI-VFPALSALLSkSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 612908240 423 VYTvlaanlnlNLGGFTGMMFNALLAIVAFLVILL 457
Cdd:cd17330  323 LYS--------FLGPGVPFLLAAGLLLIALFLLSL 349
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 22-251 2.66e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 43.13  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  22 ITFWLFAQSLVNLVVPLQSTYSSdvgtinIAVSLSALFAGLFI--VGA---GDVADKFGRVKITYVGLILNVVGSLLIII 96
Cdd:cd17368   16 GVYGFFAVYIGRLFFPSGSEFAS------LLLTFATFGVGFFMrpIGAivlGAYADRIGRKPAMTLTLAIMALGTLLIAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  97 TP--------LPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSyWSIGSwggSGICTLFGGLMATYI----- 163
Cdd:cd17368   90 APtyatigiaAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTS-WQSAS---QQVAIVAGALVGYLLsltlt 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 164 -------GWRSIFVVSILLTLLAMYLIKHAPETKAEP----------IKGMKAEAKKFDVIGLVILVVTMLSLNVIITQT 226
Cdd:cd17368  166 aealaewGWRIPFFIGLLIIPLGLWLRRSLEETEAFLerkarptrreLFALLANNRRIILLGMLLVAGSTVTFYFTTVYT 245

                        250       260
                 ....*....|....*....|....*...
gi 612908240 227 SHFG---LVSPLILGLIVVFICSLVGFV 251
Cdd:cd17368  246 PTYAktvLGLSARDSFLVTLLAGVANFI 273
Sugar_tr pfam00083
Sugar (and other) transporter;
41-204 3.27e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.03  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   41 TYSSDVGTINIAVSLSALFAGLFIVG-------AGDVADKFGRVKITYVGLILNVVGSLLIIITPL---PAFLIIGRIIQ 110
Cdd:pfam00083  33 GLSKSVSSLAALSVLSGLIVSIFSVGcfigslfAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  111 GLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATY---IGWRSIFVVSILLTLLAMYLIKHAP 187
Cdd:pfam00083 113 GIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTsnsDGWRIPLGLQLVPALLLIIGLLFLP 192

                         170
                  ....*....|....*...
gi 612908240  188 ETKAEPI-KGMKAEAKKF 204
Cdd:pfam00083 193 ESPRWLVeKGRLEEAREV 210
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
67-237 3.97e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 42.70  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  67 AGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSW 146
Cdd:PRK10473  58 AGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITC 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 147 GGSGICTLFGGLMATYIGWRSIFV----VSILLTLLAMYLIK-----HAPETKAEPIKGMKAEAKKFDVIGLVIlvvTML 217
Cdd:PRK10473 138 IIPVLAPVLGHLIMLKFPWQSLFYtmaaMGILVLLLSLFILKetrpaRAPAASSKPRENSESLLNRFFLSRLVI---TTL 214

                        170       180
                 ....*....|....*....|
gi 612908240 218 SLNVIITQTShfglVSPLIL 237
Cdd:PRK10473 215 SVTVILTFVN----TSPVLL 230
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 277-464 5.88e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 5.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 277 ISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLslT 356
Cdd:cd17329    6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL--G 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 357 FLPEMWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYtvlaanlnlNLG 436
Cdd:cd17329   84 FAHSPWLF---AIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL---------LYS 151

                        170       180
                 ....*....|....*....|....*...
gi 612908240 437 GFTGMMFNALLAIVAFLVILLLVPKNQT 464
Cdd:cd17329  152 FRLLFLAAAVLFLLAALVLLFLLPETRP 179
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 51-183 7.89e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  51 IAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYI 130
Cdd:cd17370  238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 612908240 131 GTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLI 183
Cdd:cd17370  318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 12-204 9.53e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 9.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFivgAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLI---GGRLADRFGRKPVMLAGLLLRALGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYiGWRSIF-- 169
Cdd:cd17329   80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFla 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 612908240 170 --VVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKF 204
Cdd:cd17329  159 aaVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKI 195
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 18-427 1.81e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  18 VLGVITFWLFAQSLVNLVVPLQSTySSDVGTINIAVSLSALFAGLFIVG--AGDVADKFGRVKITYVGLILNVVGSLLII 95
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLE-REGVSTALIGLVASAYYLGILLGSplVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  96 ITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYiGWRSIFVVSILL 175
Cdd:cd17477   80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 176 TL----LAMYLIKHAPETKAEPIKGMKaeakkfdviglvilvvtmlslnviitqtshfgLVSPLILGLIVVFICslvgfv 251
Cdd:cd17477  159 LLalvpLLLTRRAAPEIEEAESISLRR--------------------------------LLRIAPLALLGAFVA------ 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 252 yyenkikhplvdfsifknrgysgatisnfllnGVAGGALIVINTYYQQQLGFNSSQTGY-ISLTYLIAVLSMIRVGekIL 330
Cdd:cd17477  201 --------------------------------GFLEGAFYSLLPLYGLRLGLSVAQAALlLAAFVLGGLLLQWPLG--WL 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 331 SQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIVssIVGYLLFGTGLGLYATPSTDtAVASAPDDKSGVASGVYKMASS 410
Cdd:cd17477  247 ADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL--VLLFLWGGAAGPLYTLALAL-AGDRLPGDELVAANAALLLLYG 323

                        410
                 ....*....|....*..
gi 612908240 411 LGNAFGVAVSGTVYTVL 427
Cdd:cd17477  324 LGSVIGPLLAGALMDAF 340
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 276-460 1.90e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.27  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 276 TISNFLLNGVAGgALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSL 355
Cdd:cd17489    2 LLANFFFFLSFY-LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 356 TFlpemwYIVSSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYtvlaanlnlNL 435
Cdd:cd17489   81 AT-----SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY---------QH 146

                        170       180
                 ....*....|....*....|....*
gi 612908240 436 GGFTGMMFNALLAIVAFLVILLLVP 460
Cdd:cd17489  147 LGFAVLFIVAAVLALLALLLVFLVK 171
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 33-215 1.90e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  33 NLVVPLQSTYSSDVGTIN---------IAVSLSALFAGLFIVGAGDVADKFGRVKITY-VGLILNVVGSLLIIITPLPAF 102
Cdd:cd17391   13 SLIAPFLPLYIEQLGVTSgglvelwsgLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrASLGMAIVIGLMAFVTNVWQL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 103 LIIgRIIQGLSAACImPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIF-VVSILL---TLL 178
Cdd:cd17391   93 LIL-RLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFfITGGLLflaFLL 170

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 612908240 179 AMYLIK--HAPETKAEPIKGMKAEAKKFDVIGLVILVVT 215
Cdd:cd17391  171 TLFFVKedFKPVEKKKMVSTKEVWNSVPNPSLLISLFVT 209
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 53-189 2.61e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 39.94  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  53 VSLSALFAGLFI--VGAGDVADKFGRVKITYVGLILNVVGSLLII---ITPLPAFLIIGRIIQGLSAACIMPSTLAIINE 127
Cdd:cd17357   53 LIVSIFFIGGAIgsFISAFLANRFGRKNGLLISNALLVVSSLLMFlskSAKSPELLIFGRFLVGIACGLSTGFVPMYLQE 132

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612908240 128 YyigtrrqrALSYW--SIGSWGGSGIC--TLFGGLMA------TYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17357  133 I--------SPSELrgALGSLTQIGVTlgILLGQVFGlpsvlgTETLWPYLLFFPGIPALLQLAALPFFPES 196
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 43-189 2.73e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.91  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  43 SSDVGTINIAVSLsALFAGLFIVGAgdVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTL 122
Cdd:cd17438   33 SSNKGMLGLIVYL-GMMAGAFIWGG--LADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 123 AIINEYYIGTRRQRALS----YWSIGSWGGS----GICTLFG-----GLMATYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17438  110 AYFSEFLAREKRGEHLSwlcmFWMIGGLYASamawSIIPHYGwgfsmGTNYHFHSWRVFVIICALPCIASIIALKFMPES 189
MFS_1 pfam07690
Major Facilitator Superfamily;
277-461 3.10e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  277 ISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLslT 356
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--L 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  357 FLPEMWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTvlaanlnlNLG 436
Cdd:pfam07690  81 FASSLWLL---LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LFG 149

                         170       180
                  ....*....|....*....|....*
gi 612908240  437 GFTGMMFNALLAIVAFLVILLLVPK 461
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPP 174
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 39-178 3.12e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.90  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  39 QSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFL-IIGRIIQGLSAACI 117
Cdd:cd17353  241 QEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfVLGVALIGFCYGGG 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612908240 118 MPSTLAIINEYY----IGTRRQRALSYWSIGSWGGSGICTLF---GGLMATYIGWRSIFVVSILLTLL 178
Cdd:cd17353  321 FALFPALTADFFgtknAGTNYGLLYTAKGVGGLIGPIIAAYVlytGGYNAAFIIAAALSLVALALALL 388
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 53-189 3.84e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 39.56  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  53 VSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLS---AACIMPSTLAIINEYY 129
Cdd:cd17360   41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgiASMTVPLYIAEAAPPR 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612908240 130 IgtrRQRALSYWSIGSWGGSGICTLFGGLMA-TYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17360  121 I---RGRLVTINVLFITGGQFVAYVINGAFSyLPGGWRWMLGLAAVPAVLQFIGLLFLPES 178
PRK12307 PRK12307
MFS transporter;
44-219 4.47e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 39.14  E-value: 4.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  44 SDVGTINIAVSL--SALFAGLFIVGA--GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMP 119
Cdd:PRK12307  46 ADLGLTDMEGAFlaTAAFIGRPFGGAlfGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 120 STLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPETKaEPIKGMKA 199
Cdd:PRK12307 126 CASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESK-EWEEAKLS 204

                        170       180
                 ....*....|....*....|
gi 612908240 200 EAKKFDVIGLVILVVTMLSL 219
Cdd:PRK12307 205 GKGKHSQSAWSVFSLSMKGL 224
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 284-458 4.62e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 284 GVAGGALIVINTY---YQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSltFLPE 360
Cdd:cd17335  208 FLMGFGHGLIYSFlfwHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYS--FLEN 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 361 MWYIvssIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASS-LGNAFGVAVSGTVYTvlaanlnlNLGGFT 439
Cdd:cd17335  286 PWLV---LPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYE--------AFGART 354

                        170
                 ....*....|....*....
gi 612908240 440 GMMFNALLAIVAFLVILLL 458
Cdd:cd17335  355 TFRFFAIAALAGLLAFFLI 373
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 12-182 4.73e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  12 RLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGS 91
Cdd:cd17473  198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  92 LLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIG-----WR 166
Cdd:cd17473  278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGglsgaFL 357

                        170
                 ....*....|....*.
gi 612908240 167 SIFVVSILLTLLAMYL 182
Cdd:cd17473  358 ILGVLALVLAIVLLLL 373
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
298-462 4.93e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 4.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 298 QQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEMWYIvssivGYLLFGTG 377
Cdd:COG2807   45 RADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA-----GTALIGAG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 378 LGLYATPSTdTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGTVYTVlaanlnlnLGGFTGMMFNALLAIVAFLVILL 457
Cdd:COG2807  120 IAVGNVLLP-GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA--------LGWRGALAVWALLALLALLLWLP 190


                 ....*
gi 612908240 458 LVPKN 462
Cdd:COG2807  191 LLRRR 195
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 37-183 4.95e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.93  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  37 PLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFL-IIGRIIQGLSAA 115
Cdd:cd17314   28 PWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLsYACFVFIGAGTG 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612908240 116 CIMPSTLAIINEYYIgTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAMYLI 183
Cdd:cd17314  108 ILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVV 174
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 8-183 6.81e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240   8 RGDNRLLLGIVLGVITF-WLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLIL 86
Cdd:cd17478  190 LKGVWRALLLLLIIVFLrSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  87 NVVGSLLIIITPLPAfLIIGRIIQGLSAACIMPSTLAIINEYyiGTRRQRALSYWSIG-SWGGSGICTLFGGLMATYIGW 165
Cdd:cd17478  270 AAPFLLLFLLTPGIW-SYILLVLAGFLLFASFPVTVVLAQEL--LPGNVGLASGLMMGlSFGLGGIGAPVLGALADAFGL 346

                        170
                 ....*....|....*...
gi 612908240 166 RSIFVVSILLTLLAMYLI 183
Cdd:cd17478  347 ESVLLILALLPLLGALLA 364
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 51-179 7.32e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.40  E-value: 7.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  51 IAVSLSALFAGLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYI 130
Cdd:cd17391  244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITP 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 612908240 131 GTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLA 179
Cdd:cd17391  324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLN 372
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
275-457 7.45e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 275 ATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLS 354
Cdd:COG0738   12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240 355 LTflPEMWYIvssIVGYLLFGTGLGLYATpSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVSGtvytvLAANLNLN 434
Cdd:COG0738   92 LA--PSYPLL---LLALFLLGLGLGLLDV-AANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGG-----LLILLGLS 160

                        170       180
                 ....*....|....*....|...
gi 612908240 435 LGGFTGMMFNALLAIVAFLVILL 457
Cdd:COG0738  161 LSWHLPYLILAVLLLLLALLFLR 183
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 53-189 7.57e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.71  E-value: 7.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  53 VSLSALFAGLFIvgaGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLsAACIMPSTLAI-INEyyIG 131
Cdd:cd17358   50 LTLGALIGALLS---GKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGF-GGGAASVVVPVyIAE--IA 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 612908240 132 TRRQRALSYWSIGSWGGSGIctLFGGLMATYIGWRSIFVVSILLTLLAMYLIKHAPET 189
Cdd:cd17358  124 PKNVRGALGSLNQLLVNIGI--LLGYVLGSFLPWRTLALIGAIPPVVFLILLFFIPES 179
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 53-191 9.14e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.32  E-value: 9.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612908240  53 VSLSALFAGLFIVGA-------GDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAII 125
Cdd:cd17315   33 TSLQGLVVSSLLLGAaigslfgGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYI 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612908240 126 NEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYI--GWRSIFVVSILLTLLAMYLIKHAPETKA 191
Cdd:cd17315  113 SEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMFFLPESRA 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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