|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-435 |
9.34e-102 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 310.21 E-value: 9.34e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGM 172
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 173 LASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSI 252
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 253 LMGFTGLVLNLFLAHY-GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVIMSIGVIFVVC 330
Cdd:cd13143 241 SSSVVTIVLNLTLLGYgGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAgNYDRVKQALKLALIVALIYGLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 331 MIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPVLFIMNAL 409
Cdd:cd13143 321 FLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLrQGLFLIPLLLILPRL 400
|
410 420
....*....|....*....|....*.
gi 612907552 410 FGLTGVIWSLLIAESLCALAAMLIVY 435
Cdd:cd13143 401 FGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
9-433 |
7.60e-82 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 258.92 E-value: 7.60e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 9 FEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKD 88
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 89 YSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMIS 168
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 169 MIGMLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAF 248
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 249 LMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIKAVIMSIGVIF 327
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLgAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 328 VVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPVLFIM 406
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLrLWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*...
gi 612907552 407 NAL-FGLTGVIWSLLIAESLCALAAMLI 433
Cdd:COG0534 400 AFLgLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
14-440 |
6.96e-63 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 209.62 E-value: 6.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 14 VFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSK 93
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 94 FVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGML 173
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 174 ASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSIL 253
Cdd:cd13138 161 IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 254 MGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNK-GRMKDVIKAVIMSIGVIFVVCMI 332
Cdd:cd13138 241 VSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKiERAKKGLRTGIIISLIIGLIIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 333 AVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVI-IPVLFIMNALF- 410
Cdd:cd13138 321 LVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVrIPLAYLLSRLTg 400
|
410 420 430
....*....|....*....|....*....|.
gi 612907552 411 -GLTGVIWSLLIAESLCALAAMLIVYLLRDR 440
Cdd:cd13138 401 lGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-433 |
3.91e-59 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 199.77 E-value: 3.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMIsAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13144 5 PVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALT-AVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGM 172
Cdd:cd13144 84 NKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 173 LASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAF 248
Cdd:cd13144 164 LIGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGLPSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 249 LMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIKAVIMSIGVIF 327
Cdd:cd13144 244 IMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYgAGNKDRIREAIKYAILIAVVIM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 328 VVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPVLFIM 406
Cdd:cd13144 324 LAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVArQLVVLLPLAWLL 403
|
410 420
....*....|....*....|....*..
gi 612907552 407 NALFGLTGVIWSLLIAESLCALAAMLI 433
Cdd:cd13144 404 AKMFGLNGVWWSFPIAEIVSFLLSLLF 430
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
22-435 |
9.08e-58 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 196.01 E-value: 9.08e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 22 SLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIY 101
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRL-LGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 102 GGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNII 181
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 182 LDPILIFGF---DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTG 258
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 259 LVLNLFLAHY-GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVIMSIGVIFVVCMIAVFT 336
Cdd:cd12082 240 LIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAgNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 337 IGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQ-GVVIIPVLFIMNAL-FGLTG 414
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSyWVVRLPLAYVLAYLgLGLYG 399
|
410 420
....*....|....*....|.
gi 612907552 415 VIWSLLIAESLCALAAMLIVY 435
Cdd:cd12082 400 IWLALVISLILAALVLLLFFR 420
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-433 |
7.96e-54 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 185.79 E-value: 7.96e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 16 KAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHmISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFV 95
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEA-IAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 96 SSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLAS 175
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 176 VGLNIILDPILIFG----FDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMS 251
Cdd:cd13137 160 NVLNIVLDYVLIFGlwgfPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 252 ILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNK--GRMKDVIKAVIMSIGVIFVV 329
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDpdEARRYGKRALRLGVLFMGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 330 CmIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRG---ATIMAILQGVVIIPVLFIM 406
Cdd:cd13137 320 G-LLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPpliINLISMWLVRLPLAYLLGF 398
|
410 420
....*....|....*....|....*..
gi 612907552 407 NALFGLTGVIWSLLIAESLCALAAMLI 433
Cdd:cd13137 399 VLGLGLTGIWLAMFVDTIVRAILLLYR 425
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-432 |
1.07e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 172.38 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHmISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13142 8 SILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADA-VAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAA-ILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIG 171
Cdd:cd13142 87 NKVAGQTFSFVIILSLILAVLGYILSRPLLLlLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 172 MLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPA 247
Cdd:cd13142 167 MFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKIFRIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 248 FLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIKAVIMSIGVI 326
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLgAGQIDRAEEIVKKAALLIFLI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 327 FVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPV--L 403
Cdd:cd13142 327 LVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILrLWVIRIPLayL 406
|
410 420
....*....|....*....|....*....
gi 612907552 404 FIMNALFGLTGVIWSLLIAESLCALAAML 432
Cdd:cd13142 407 LAYVLGLGVTGIWIAMAISNIVAALIALA 435
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
16-441 |
3.62e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 170.80 E-value: 3.62e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 16 KAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFV 95
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGL-GADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 96 SSFSIYGGIALGLIVILVALPFSDQIAAILGArGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLAS 175
Cdd:cd13147 88 AVHSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 176 VGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFI-VYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILM 254
Cdd:cd13147 167 SILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLyWFFVKKDTYVSLSLKNFKFDKKIVKDILKVGIPASLEQLIM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 255 GFTGLVLNLFLAHY-GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVImSIGVIFVVC-M 331
Cdd:cd13147 247 SVLMIILNLILVIVaGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGArNYEKLKTAYNYSI-KLGLIIELIiA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 332 IAVFTIGHHMVGLFTTDQAIVEMA---TFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPV---LFI 405
Cdd:cd13147 326 ILIFIFAPQIAYLFTYSEESAHLApeiVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLfayLFA 405
|
410 420 430
....*....|....*....|....*....|....*.
gi 612907552 406 MNALFGLTGVIWSLLIAESLCALAAMLIVYLLRDRL 441
Cdd:cd13147 406 IVLGLGLFGVWWGIVLGNAIGSIVGYLWARLYIKRL 441
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-434 |
3.19e-44 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 160.16 E-value: 3.19e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13149 6 SIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKL-GTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGM 172
Cdd:cd13149 85 KRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 173 LASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAF 248
Cdd:cd13149 165 LGAALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIGIPAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 249 LMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKGRMKDVIKAVIMSIGVIFV 328
Cdd:cd13149 245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 329 VCMIAVFTIG-HHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQG-VVIIPVLFIM 406
Cdd:cd13149 325 AILGIVLALFaGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVfLLYIPLAYVG 404
|
410 420
....*....|....*....|....*...
gi 612907552 407 NALFGLTGVIWSLLIAESLCALAAMLIV 434
Cdd:cd13149 405 SHLLGFAGVFIGALAGNLIAGILAYFIA 432
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-435 |
1.73e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 144.47 E-value: 1.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFL--EDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYS 90
Cdd:cd13146 5 PISPLLIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 91 KSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMI 170
Cdd:cd13146 85 ELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 171 GMLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLM 250
Cdd:cd13146 165 AMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 251 SILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIK-AVIMSIGVIFV 328
Cdd:cd13146 245 QLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWgRGNYDRMLQILMtAVILGIVVVLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 329 VCMIAVFtIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVI-IPVLFIMN 407
Cdd:cd13146 325 LVLGYVL-VAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLsVPVVYLLA 403
|
410 420 430
....*....|....*....|....*....|
gi 612907552 408 ALF--GLTGVIWSLLIAESLCALAAMLIVY 435
Cdd:cd13146 404 YVFgkGITGVYFGIVSANFFTALLAMFWGL 433
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-433 |
2.21e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 144.68 E-value: 2.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 9 FEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDsHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKD 88
Cdd:cd13139 7 FTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGA-LAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 89 YSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMIS 168
Cdd:cd13139 86 PEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 169 MIGMLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIG 244
Cdd:cd13139 166 MRSLWLANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKIIKIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 245 IPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKgrmKDVIKAVIMSIG 324
Cdd:cd13139 246 VGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQ---PDRAEKSVWRAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 325 VIFVVCMIAV----FTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVI- 399
Cdd:cd13139 323 KYNMVFLGIVslvfFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFq 402
|
410 420 430
....*....|....*....|....*....|....*.
gi 612907552 400 IPVLFIMNALFGL--TGVIWSLLIAESLCALAAMLI 433
Cdd:cd13139 403 IPLAYLLARHLNLgpKGVFIAIPIAETVLAIAAIIL 438
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-421 |
4.59e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 143.43 E-value: 4.59e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13140 2 PILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRL-GSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILG-ARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIG 171
Cdd:cd13140 81 RKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 172 MLASVGLNIILDPILIFGFD----LNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPA 247
Cdd:cd13140 161 NAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 248 FLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKG-RMKDVIKAVIMSIGVI 326
Cdd:cd13140 241 ALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYdRIRKGYKTALKIASAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 327 FVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPV-LFI 405
Cdd:cd13140 321 GLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNGLRIPLaLLL 400
|
410
....*....|....*.
gi 612907552 406 MNALFGLTGVIWSLLI 421
Cdd:cd13140 401 SPTGLGLNGIWWAISI 416
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
24-359 |
2.89e-37 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 138.92 E-value: 2.89e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 24 PMMIGTLLSVIYGILNIYFIGFLEDSHMiSAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGG 103
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDL-AAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 104 IALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNIILD 183
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 184 PILIFGF--DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVL 261
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 262 NLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKG-RMKDVIKAVIMSIGVIFVVCMIAVFTIGHH 340
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPkRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330
....*....|....*....
gi 612907552 341 MVGLFTTDQAIVEMATFIL 359
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYL 338
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
15-438 |
2.18e-36 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 138.46 E-value: 2.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 15 FKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKF 94
Cdd:cd13136 2 HREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 95 VSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLA 174
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 175 SVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILM 254
Cdd:cd13136 162 GNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 255 GFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIKAViMSIGVIFVVCMIA 333
Cdd:cd13136 242 LAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALgAGDRKAARRVARRL-LQWGLGLGVLLAL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 334 VFTIGHHMV-GLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGL 412
Cdd:cd13136 321 LFFLGGEPIiRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLWGN 400
|
410 420
....*....|....*....|....*.
gi 612907552 413 TGVIWSLLIaeSLCALAAMLIVYLLR 438
Cdd:cd13136 401 HGLWLALIL--FMLLRGLTLALRLPR 424
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-441 |
8.27e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 137.45 E-value: 8.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 1 MKDeqlyyFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDsHMISAISLTLPVFAILMGLGNLFGVGAGTYI 80
Cdd:cd13141 1 MKD-----LTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGD-AALAGVSLAGNVMFFVMALTQVLNVGTAALV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 81 SRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFAR 160
Cdd:cd13141 75 SHAVGRKDQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 161 AIGAPMISMIGMLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEM 236
Cdd:cd13141 155 GTGIVKPFMVIQILAVLLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 237 LSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKG-RMKDV 315
Cdd:cd13141 235 WKRLLKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYdRVRET 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 316 IKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATI-MAIL 394
Cdd:cd13141 315 FRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLsSASR 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 612907552 395 QGVVIIPVLFIMNALFGLTGVIWSLLIAESLCALAAMLivYLLRDRL 441
Cdd:cd13141 395 LLTFALPVIWLSAQPDFRIEQIWYLSVATTILQAALSL--LLLRREL 439
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-434 |
2.18e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 133.49 E-value: 2.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 11 KSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDShMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYS 90
Cdd:cd13145 4 KGPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTE-ALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 91 KSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMI 170
Cdd:cd13145 83 KARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 171 GMLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIP 246
Cdd:cd13145 163 FLIIGFFLNIILDPLFIFGGggipAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 247 AFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNK-GRMKDVIKAVIMSIGV 325
Cdd:cd13145 243 ASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKyDRVRETYKKALKYGFV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 326 IFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPVLF 404
Cdd:cd13145 323 IMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYrQLVGPALVFW 402
|
410 420 430
....*....|....*....|....*....|..
gi 612907552 405 IMNALFG--LTGVIWSLLIAESLCALAAMLIV 434
Cdd:cd13145 403 LLVNVLGlgVTGIWWGIFTIVWSAAIIALLYT 434
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-423 |
5.67e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 126.46 E-value: 5.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 22 SLPMMIGTLLSVIYGILNIYFIGFLEDShMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIY 101
Cdd:cd13134 9 AWPIFIELLLQMLLGTIDTFMLSRYSDN-AVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 102 GGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNII 181
Cdd:cd13134 88 FNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 182 LDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFT 257
Cdd:cd13134 168 GNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEELSYNLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 258 GLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYnfMSNKGRMKDVIKAVIMSIGVIFVVC---MIAV 334
Cdd:cd13134 248 QTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGH--LVGAGDFDEAYKRVLKSLKIGLLVSlavALLL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 335 FTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL-QGVVIIPV--LFIMNALFG 411
Cdd:cd13134 326 ALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIIsMWGISVPLayLLGIVLGLG 405
|
410
....*....|..
gi 612907552 412 LTGVIWSLLIAE 423
Cdd:cd13134 406 LLGVWIAFAADE 417
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
21-415 |
1.17e-29 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 120.10 E-value: 1.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 21 FSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSI 100
Cdd:PRK09575 17 YTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 101 YGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNI 180
Cdd:PRK09575 97 LLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 181 ILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLV 260
Cdd:PRK09575 177 VLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSFVVAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 261 LNLFLAHYGN-FAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF----MSNKGRMKDVIKAVIMSIGVIFVVCMIAvf 335
Cdd:PRK09575 257 HNRLFMEYGSaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFgarqYDNIKKLLKLAMKVTVLAGIAWVLLLNL-- 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 336 tIGHHMVGLFTT-DQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTG 414
Cdd:PRK09575 335 -FPETMIALFNSgDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIGNMLIQLPFLFILPKWLGVDG 413
|
.
gi 612907552 415 V 415
Cdd:PRK09575 414 V 414
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-438 |
4.21e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 118.40 E-value: 4.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 16 KAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMgLGNLFGVGAGTYISRLLGAKDYSKSKFV 95
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILM-LFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 96 SSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLAS 175
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 176 VGLNIILDPILIFG----FDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLA-KPNKEMLSEIFKIGIPAFLM 250
Cdd:cd13133 164 VVVNIVLDYALIFGklgfPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAwRFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 251 SILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAyNFMSnKGRMKDVIKAV--IMSIGVIFV 328
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVG-QALG-AGRPDLAMRVTrrGLKLALAYM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 329 VCMIAVF-TIGHHMVGLFTTD---QAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATI--MAILQGVVIIPV 402
Cdd:cd13133 322 LLLGILFlLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLaeLIVAWLYLLPPA 401
|
410 420 430
....*....|....*....|....*....|....*.
gi 612907552 403 LFIMNALFGLTGVIWSLLIaeSLCALAAMLIVYLLR 438
Cdd:cd13133 402 YLLVVLGAGLAGAWTVETV--YVIVLALIFLLRFRS 435
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
15-440 |
5.60e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 109.51 E-value: 5.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 15 FKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMIS-AISLTLPVFAILMGLGNLFGVGAgtYISRLLGAKDYSKSK 93
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAvALGSSLWFPVFTFGMGLLLAVTP--LVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 94 FVSSFSIYGGIALGLIVILVALpFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGML 173
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLW-LAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 174 ASVGLNIILDPILIFG----FDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNI--KLAKPNKEMLSEIFKIGIPA 247
Cdd:cd13131 159 LALVLNIPLNYVLIFGkfglPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLfaRFWRPDWARLKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 248 FLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGRMKDVIKAVIMSIGVI 326
Cdd:cd13131 239 GLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALgAGDPADARRAGLVGLGLGVGF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 327 FVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVI-IPVLFI 405
Cdd:cd13131 319 AALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIgLPLGYL 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 612907552 406 MNALFGLTGV-IWSLLIAESLCALAAMLIVYLLRDR 440
Cdd:cd13131 399 LAFTTGLGAFgVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-423 |
7.44e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 103.14 E-value: 7.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 16 KAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLfGVGAGTYISRLLGAKDYSKSKFV 95
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSI-SIGFTILGSQSVGAKDIKRINDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 96 SSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLAS 175
Cdd:cd13135 80 AISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 176 VGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVV--SVNIKLAKPNKEMLSEIFKIGIPAFL 249
Cdd:cd13135 160 NLLNVILDYVLIFGNfgfpRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTfkLSNTKVLKANIRPYKFTIKLGLPLGG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 250 MSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFmsNKGRMKDVIKAVIMSIGVIFVV 329
Cdd:cd13135 240 EEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESI--GKKDLKEALRIGNICLGLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 330 CMIA---VFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQG--VVIIPVLF 404
Cdd:cd13135 318 YIAAaivFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTiiVVSVALLL 397
|
410
....*....|....*....
gi 612907552 405 IMNALFGLTGVIWSLLIAE 423
Cdd:cd13135 398 IFVFKLGLAGVYITLFIDE 416
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-440 |
1.53e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 99.27 E-value: 1.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGN-LFGVGAGTYISRLLGAKDYSK 91
Cdd:cd13148 9 PILPTLLRLALPNILALLVQTLVGLAETYFVGQL-GTDALAGVALVFPLLMLTQMMSNgAMGGGVSSAIARALGAGDRER 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 92 SKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIG 171
Cdd:cd13148 88 AEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 172 MLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPA 247
Cdd:cd13148 168 TLVGAVVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFRDILRVGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 248 FLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFmsNKGRMKDVIKAVIMSIGVIF 327
Cdd:cd13148 248 ALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNI--GAGQIARARRIAWTGALMAA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 328 VVC-----MIAVFTigHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPV 402
Cdd:cd13148 326 VLAgaiglVLALFP--ELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTLRLLIAAGG 403
|
410 420 430
....*....|....*....|....*....|....*...
gi 612907552 403 LFIMNALFGLTGVIWSLLIAESLCALAAMLIVYLLRDR 440
Cdd:cd13148 404 GWIAVALFGAGLAGLFAAAAAAMVAYGLVTAAAVKLGA 441
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
15-435 |
1.86e-21 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 96.10 E-value: 1.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 15 FKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMiSAISLTLPVFAILmGLGNLFGVGAG--TYISRLLGAKDYSKS 92
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLEL-AAASLASSFANVT-GFSILLGLASAldTLCGQAFGAKNYKLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSsfsIYGGIALGLIVILVALP--FSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMI 170
Cdd:cd13132 80 GVYL---QRALVILLLCCVPISLLwlNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 171 GMLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLM 250
Cdd:cd13132 157 ISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALM 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 251 SIL--MGFTGLVLnlfLAHY--GNFAIASYGISFRLVQFPELIIMGLCEGvvpliAYNFMSNK---GRMKDVIKAVIMSI 323
Cdd:cd13132 237 LCLewWAFEILVL---LAGLlpGTVALAAQSICLTTTSLLYMIPLGISIA-----ASVRVGNElgaGNPKRAKLAAIVAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 324 G---VIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATG-QGRGATIMAILQGVVI 399
Cdd:cd13132 309 IlslVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGrQKLGAYVNLVAYYLIG 388
|
410 420 430
....*....|....*....|....*....|....*...
gi 612907552 400 IPVLFIMNALF--GLTGVIWSLLIAESLCALAAMLIVY 435
Cdd:cd13132 389 LPVGLLLAFVLglGLKGLWIGLIAGLILQAVILLLIIL 426
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
24-185 |
3.60e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 72.98 E-value: 3.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 24 PMMIGTLLSVIYGILNIYFIGFLEDSHMiSAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGG 103
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVAL-AAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 104 IALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNIILD 183
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 612907552 184 PI 185
Cdd:pfam01554 160 YL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
56-385 |
7.49e-12 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 66.76 E-value: 7.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 56 SLTLPVFAILMGLgnLFGVGAgtYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALT 135
Cdd:PRK01766 55 SIWLPVILFGHGL--LLALTP--IVAQLNGAGRRERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 136 SNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNIILDPILIFGF----DLNVVGAALGTAISNVAAALF 211
Cdd:PRK01766 131 VGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYWVMFLA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 212 FIVYFMKNSDVVSVNI--KLAKPNKEMLSEIFKIGIPAFLmSILMGfTGL--VLNLFLAHYGNFAIASYGISFRLVQFPE 287
Cdd:PRK01766 211 MLIYIKRARRFRDFRLfkGLYKPDWAVIKRLLKLGLPIGL-AIFFE-VSLfaVVTLLVSPLGTVTVAAHQIALNFSSLLF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 288 LIIMGLCEGVVplIAYNFMSNKGRMKDVIKAVIMSIGV---IFVVCMIAVFTIGHHMVGLFTTDQAIVEMAtfilkvtmT 364
Cdd:PRK01766 289 MLPLSLAMALT--IRVGFELGAGRTLDARQYAYIGLAVglgMALLTAIFLVLFREQIALLYTDDPEVVALA--------S 358
|
330 340
....*....|....*....|.
gi 612907552 365 SLLLNGIGFLFTGMLQATGQG 385
Cdd:PRK01766 359 HLLLFAALFQFSDAIQVIGSG 379
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
240-435 |
3.12e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 64.83 E-value: 3.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 240 IFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFmsNKGRMKDVIKAV 319
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYL--GAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 320 IMSIGVIFV---VCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQG 396
Cdd:cd13134 83 GVALLFNLLlglVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMN 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 612907552 397 VVIIpvlfIMNALF----------GLTGVIWSLLIAESLCALAAMLIVY 435
Cdd:cd13134 163 ILNI----VGNYLLifgwfglpklGVAGVAISTVISRAVGLVLLFILLF 207
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-219 |
8.54e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 63.63 E-value: 8.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLeDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd13138 222 EILKEILKIGLPSALQQSLVSISFLIINSIVNSY-GVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMI-G 171
Cdd:cd13138 301 KKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIiS 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 612907552 172 MLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKN 219
Cdd:cd13138 381 ILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
233-441 |
1.70e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 62.47 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 233 NKEMLSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNF-MSNKGR 311
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALgAGDREE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 312 MKDVIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIM 391
Cdd:COG0534 83 ARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMII 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 612907552 392 AILQGVVIIP--VLFIMNALFGLTGVIWSLLIAESLCALAAMLIVYLLRDRL 441
Cdd:COG0534 163 MLIGNVLNIVldPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLL 214
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
154-438 |
9.81e-10 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 60.17 E-value: 9.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 154 ILEQFARAIGapMISMIGMLASVGLNIildpilifgfDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLA--- 230
Cdd:cd13124 148 VIEQIVRVIV--ILVLAYLLLPVGGGL----------YYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSprs 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 231 -KPNKEMLSEIFKIGIP---------------AFLMSILMGFTGLVLNLFLAHYGNFAiasyGISFRLVQFPELIIMGLC 294
Cdd:cd13124 216 kISTKEILKELLSYAIPitlsslilpllqlidSFTVPRRLQAAGLSESEATALYGILT----GRAQPLVQLPTVIATALS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 295 EGVVPLIAYNFMsnKGRMKDVIKAVIMSIGVIFVVCMIAVFTI----GHHMVGLFTTDQAivemaTFILKVTMTSLLLNG 370
Cdd:cd13124 292 TSLVPAISEAYA--KGDKKELRRRINQALRLTLLIGLPAAVGLavlaEPINTLLFGDSEG-----GLILQILAPSILFLS 364
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612907552 371 IGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVIWSLLIAesLCALAAMLIVYLLR 438
Cdd:cd13124 365 LQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIG--FLVAALLNLRALKK 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
246-405 |
5.64e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 54.88 E-value: 5.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 246 PAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVIMSIG 324
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAgNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 325 VIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLF 404
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 612907552 405 I 405
Cdd:pfam01554 161 L 161
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
154-435 |
9.58e-09 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 57.48 E-value: 9.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 154 ILEQFARAIGapMISMIGMLASVGLNIIldpilifgfdlnVVGAALGTAISNVAAALFFIVYFMK-----NSDVVSVNIK 228
Cdd:COG5841 158 VIEQIVRVIF--ILLLAYLLLPYGLEYA------------AAGATFGAVIGALAGLLVLLYYYRKrkkklKRLLEKSKTK 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 229 LAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNLF----LAHYG---NFAIASYGI----SFRLVQFPELIIMGLCEGV 297
Cdd:COG5841 224 SKESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTvprrLQAAGlsaSEATSLYGIlsgmAQPLVNLPTVLATALATSL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 298 VPLIAYNFmsNKGRMKDVIKAVIMSIGVIFVVCMIAV---FTIGHHMVGLFTTDQAivemATFILKVTMTSLLLNGIGFL 374
Cdd:COG5841 304 VPAISEAF--AKKDRKLVRRRINQALRLTLLIGLPAAvglAVLAEPINTLLFGNPE----GGGILAILAPSAIFLSLQQV 377
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612907552 375 FTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVIWSLLIAESLCALAAMLIVY 435
Cdd:COG5841 378 TTGILQGLGKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALK 438
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
13-216 |
5.45e-08 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 54.64 E-value: 5.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKS 92
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 93 KFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGM 172
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 612907552 173 LASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYF 216
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
104-438 |
9.75e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 54.00 E-value: 9.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 104 IALGLIVILVALPFSDQIAAIL--GARGETLALTSNYLKVMFLSAPFVILFFIL-------EQFARAIGAPMISMIGMLA 174
Cdd:COG0728 89 LLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMFPYILFIGLSALLggvlnarGRFAAPALAPVLLNLVIIA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 175 SVGLniildpiLIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNkemLSEIFKIGIPAFLMSILM 254
Cdd:COG0728 169 GLLL-------LAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPG---VRRVLKLMLPALLGVSVS 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 255 GFTGLVLNLFLAHYGNFAIASYGISFRLVQFPE-LIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVIMSIGVIFVVCMI 332
Cdd:COG0728 239 QINLLVDTILASFLPEGSVSALYYADRLYQLPLgLFGVAIGTALLPRLSRAAAAgDLEEFRRTLSRGLRLVLLLTLPAAV 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 333 AVFTIGHHMVGLF----TTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNA 408
Cdd:COG0728 319 GLIVLAEPIVRLLfergAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP 398
|
330 340 350
....*....|....*....|....*....|
gi 612907552 409 LFGLTGVIWSLLIaeSLCALAAMLIVYLLR 438
Cdd:COG0728 399 PLGHAGLALATSL--SALVNALLLLVLLRR 426
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
25-435 |
1.47e-07 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 53.31 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 25 MMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGT-YISRLLGAKDYSKSKFVSSFSIYGG 103
Cdd:cd13128 8 LFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVrEIARYRKEKIREIISTSLVLKLILG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 104 IALGLIVILVALPFSDQIAailgargetlaLTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNIILD 183
Cdd:cd13128 88 ILALLLLFLFAFLIAFYDP-----------ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 184 PILIFgFDLNVVGAALGTAISNVAAALFFIVYFMKNSdvvsVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNL 263
Cdd:cd13128 157 LILVL-LGGGLIGFALAYLIASVLSAILLLYIYRKKI----LLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 264 FLAHY-GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMV 342
Cdd:cd13128 232 MLGYFlGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPII 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 343 GLFTTDQAIveMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVIWSLLIA 422
Cdd:cd13128 312 TLLFGEEYL--PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLIS 389
|
410
....*....|...
gi 612907552 423 ESLCALAAMLIVY 435
Cdd:cd13128 390 EFIIFILLLYLLK 402
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
11-266 |
2.36e-07 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 52.84 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 11 KSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDShMISAISLTLPVFAILMGlgnLFGVGAGT----YISRLLGA 86
Cdd:COG0728 217 RDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPEG-SVSALYYADRLYQLPLG---LFGVAIGTallpRLSRAAAA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 87 KDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARG----ETLALTSNYLKVMFLSAPFVILFFILEQFARAI 162
Cdd:COG0728 293 GDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGaftaEDTALTALALAAYALGLPAFALVKVLARAFYAR 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 163 GAPMISMIGMLASVGLNIILDPILIFGFDlnVVGAALGTAISNVAAALFFIVYFMKNSDVVsvniklakPNKEMLSEIFK 242
Cdd:COG0728 373 QDTRTPVRIAVIAVVVNIVLNLLLVPPLG--HAGLALATSLSALVNALLLLVLLRRRLGGL--------PLRGILRTLLK 442
|
250 260
....*....|....*....|....
gi 612907552 243 IGIPAFLMSILMGFTGLVLNLFLA 266
Cdd:COG0728 443 LLLASLVMGAVLWLLLRLLGDWLG 466
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
12-210 |
6.13e-06 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 48.20 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 12 SPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSK 91
Cdd:PRK10367 5 TSSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 92 SKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLKVMFLSAP-----FVILFFILE-QFARAigaP 165
Cdd:PRK10367 85 LARALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPaslanLVLLGWLLGvQYARA---P 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 612907552 166 MISMIgmlasVG--LNIILDPILIFGFDLNVVGAALGTAISNVAAAL 210
Cdd:PRK10367 162 VILLV-----VGniLNIVLDLWLVMGLHMNVQGAALATVIAEYATLL 203
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
61-218 |
6.77e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 48.34 E-value: 6.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 61 VFAILMGLGNlfgvGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSNYLK 140
Cdd:cd13142 285 VFLPAFGLAR----ATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLR 360
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612907552 141 VMFLSAPFVILFFILEQFARAIGAPMISM-IGMLASVGLNIILDPILIFGFDLNVVGAALGTAISNVAAALFFIVYFMK 218
Cdd:cd13142 361 IVAPSFPFFGLFQVINGAFRGSGHTLTAMiISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKR 439
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
17-213 |
8.06e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 47.64 E-value: 8.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 17 AMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVS 96
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 97 SFSIYGGIALGLIVILVALPFSDQIAAILGarGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASV 176
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLF--GPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190
....*....|....*....|....*....|....*..
gi 612907552 177 GLNIILDPILIFGFDLnvVGAALGTAISNVAAALFFI 213
Cdd:COG2244 332 VLNLVLNLLLIPRYGL--VGAAIATLLSYLVLLLLLL 366
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
67-431 |
1.63e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 46.87 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 67 GLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVALPFsdqIAAILGARGETLALTSNYLKVMFLSA 146
Cdd:COG2244 16 LLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRF---IAEYREEELRRLLSTALLLRLLLSLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 147 PFVILFFILEQFARAIGAPMISMIGMLASVGLNIILDPILIFGF---DLNVVGAALGTAISNVAAALFFIVYFMKNSDVV 223
Cdd:COG2244 93 LALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAVLLALlrgLERFKLLALINILSSLLSLLLALLLALLGLGLW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 224 SVniklakpnkemlseIFKIGIPAFLMSILMGFTGLVLNLFLAHY-GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIA 302
Cdd:COG2244 173 GL--------------VLKYSLPLLLSGLLGLLLTNLDRLLLGALlGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 303 YNFMS-NKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQaiVEMATFILKVTMTSLLLNGIGFLFTGMLQA 381
Cdd:COG2244 239 RLLAEgDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 612907552 382 TGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVIWSLLIAESLCALAAM 431
Cdd:COG2244 317 LGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
15-216 |
2.48e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 46.38 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 15 FKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKF 94
Cdd:cd13128 205 AKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKKL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 95 VSSFSIYGGIALGLIVILVALpFSDQIAAILGarGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLA 174
Cdd:cd13128 285 LKKSFKYLFLISLPIAIGLFL-FAEPIITLLF--GEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 612907552 175 SVGLNIILDPILIFGFDlnVVGAALGTAISNVAAALFFIVYF 216
Cdd:cd13128 362 GALLNVILNLLLIPKYG--IIGAAIATLISEFIIFILLLYLL 401
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
130-283 |
3.90e-05 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 45.88 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 130 ETLALTsnYLKVMFLSAPFVILFFILEQFARAIG---APMISMIGMLAsvgLNIILDPILIFGF----DLNVVGAALGTA 202
Cdd:PRK10189 146 KALALT--YLELTVWSYPAAAITLIGSGALRGAGntkIPLLINGGMNI---LNIIISSILIYGLfswqGLGFVGAGLGLT 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 203 ISNVAAALFFIVYFMK---NSDVVSVNIKLAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGIS 279
Cdd:PRK10189 221 ISRYIGAVAIIWVLMIgfnPALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIA 300
|
....
gi 612907552 280 FRLV 283
Cdd:PRK10189 301 FSIA 304
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
104-438 |
9.52e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 44.37 E-value: 9.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 104 IALGLIVILVALpFSDQIAAIL--GARGETLALTSNYLKVMFLSAPFVILFFIL-------EQFARAIGAPMISMIGMLA 174
Cdd:cd13123 83 LVLLLLTLLGIL-FAPLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLggilnahGRFFAPALAPVLLNLVIIA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 175 SVGLniildpiLIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKLAKPNkemLSEIFKIGIPAFLMSILM 254
Cdd:cd13123 162 GLLL-------LAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPG---VRRVLKLMLPALLGVSVS 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 255 GFTGLVLNLFLAHYGNFAIASYGISFRLVQFP-ELIIMGLCEGVVPLIAYNFMS-NKGRMKDVIKAVIMSIGVIFVVCMI 332
Cdd:cd13123 232 QINLLVDTILASFLPEGSISALYYADRLYQLPlGIFGVAIATALLPRLSRLAAAgDLDEFRRTLSRGLRLVLFLLLPAAV 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 333 AVFTIGHHMV------GLFTTDQAIveMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIM 406
Cdd:cd13123 312 GLIVLAEPIVrllferGAFTAEDTL--MTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLL 389
|
330 340 350
....*....|....*....|....*....|..
gi 612907552 407 NALFGLTGVIWSLLIAESLCALaaMLIVYLLR 438
Cdd:cd13123 390 IKPLGHVGLALATSLSAWVNAL--LLLVLLRR 419
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
185-436 |
1.64e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 43.63 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 185 ILIFGFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVNIKlAKPNKEMLSEIFKIGIPAFLMSILMGFTGLVLNLF 264
Cdd:cd13129 163 MWIGVYIRGLVGAVVILLASAAGNVASNSLILRRECQNQRGPVR-TGLTWQELRVLFKFSLPSVLSGSMGSPVHWIALAI 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 265 LAHY--GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSNKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMV 342
Cdd:cd13129 242 LVNQpnGYAELGLFNAANQWRQFITFLPATLGNVALPFLAENFGNNEGMFRQTFRSALLFGLGLSLPLGCVFILASQIFA 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 343 GLFTTDQAIvemATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFIMNALFGLTGVIWSLLIA 422
Cdd:cd13129 322 WLYGKEYGS---AAASMRSLAVAAILVGLSVLLGQIIASSGKIWRGFALNMVWSVIYVAAAYLLLRLYGAPGLALAMSAA 398
|
250
....*....|....
gi 612907552 423 EslCALAAMLIVYL 436
Cdd:cd13129 399 Y--CVLIIFQTLTL 410
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
15-218 |
6.46e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 41.79 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 15 FKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKF 94
Cdd:cd13132 223 WGPFLKLAIPSALMLCLEWWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 95 VSSFSIYGGIALGLIVILVALPFSDQIAAILGARGETLALTSnylKVMFLSAPFVILFFI---LEQFARAIGAPMISMIG 171
Cdd:cd13132 303 AAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVA---DLLPILALFQIFDGLqavLSGVLRGCGRQKLGAYV 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612907552 172 MLAS---VGLNIILdpILIFGFDLNVVGAALGTAISNVAAALFFIVYFMK 218
Cdd:cd13132 380 NLVAyylIGLPVGL--LLAFVLGLGLKGLWIGLIAGLILQAVILLLIILR 427
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-216 |
1.42e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.90 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 11 KSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDShMISAISLTLPVFAILMGLgnlFGVGAGT----YISRLLGA 86
Cdd:cd13123 210 RDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPEG-SISALYYADRLYQLPLGI---FGVAIATallpRLSRLAAA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 87 KDYSKSKFVSSFSIYGGIALGLIVILVALPFSDQIAAILGARG----ETLALTSNYLKVMFLSAPFVILFFILEQFARAI 162
Cdd:cd13123 286 GDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGaftaEDTLMTASALAAYALGLPAFALVKLLSRAFYAL 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 612907552 163 GAPMISMIGMLASVGLNIILDPILIFGFDlnVVGAALGTAISNVAAALFFIVYF 216
Cdd:cd13123 366 KDTKTPVKIAVIAVAVNILLNLLLIKPLG--HVGLALATSLSAWVNALLLLVLL 417
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
236-445 |
5.34e-03 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 39.09 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 236 MLSEIFKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQ-FPELIIMGLCEGVVPLIAYNFMSNKGRMKD 314
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANvTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612907552 315 VIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAIL 394
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612907552 395 QGVVIIPV--LFIMNALFGLTGVIWSLLIaeSLCALAAMLIVYLLRDRLTVDT 445
Cdd:cd13132 161 ALLLNILLnyLLVFVLGLGFIGAALATSI--SYWLIVVLLLLYIFFSKGHKAT 211
|
|
| |
