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Conserved domains on  [gi|612673659|gb|EZS89719|]
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choline dehydrogenase [Staphylococcus aureus VET0159R]

Protein Classification

choline dehydrogenase( domain architecture ID 11479750)

oxygen-dependent choline dehydrogenase catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate

EC:  1.1.99.1
Gene Ontology:  GO:0008812

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 4-565 0e+00

choline dehydrogenase; Validated


:

Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1050.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   4 KNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVA 83
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDYRWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  84 HARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGaaPYDKFRGHDGPIKLKRG-PATNP 162
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELPGLEGWSYADCLPYFKKAETRDG--GEDDYRGGDGPLSVTRGkPGTNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 163 LFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTY 242
Cdd:PRK02106 160 LFQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFEGKRAVGVEY 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 243 KKNGKLHTINAN-EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLD 321
Cdd:PRK02106 240 ERGGGRETARARrEVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPVSLYPALK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 322 IKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKI 401
Cdd:PRK02106 320 WWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSPSRGSVKL 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 402 KSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAK 481
Cdd:PRK02106 400 KSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAYHPSCTCK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 482 MGPasDPMAVVDPLTmKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGA 561
Cdd:PRK02106 480 MGT--DPMAVVDPEG-RVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDWPVRQRA 556


                 ....
gi 612673659 562 IEVK 565
Cdd:PRK02106 557 QRPR 560
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 4-565 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1050.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   4 KNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVA 83
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDYRWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  84 HARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGaaPYDKFRGHDGPIKLKRG-PATNP 162
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELPGLEGWSYADCLPYFKKAETRDG--GEDDYRGGDGPLSVTRGkPGTNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 163 LFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTY 242
Cdd:PRK02106 160 LFQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFEGKRAVGVEY 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 243 KKNGKLHTINAN-EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLD 321
Cdd:PRK02106 240 ERGGGRETARARrEVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPVSLYPALK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 322 IKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKI 401
Cdd:PRK02106 320 WWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSPSRGSVKL 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 402 KSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAK 481
Cdd:PRK02106 400 KSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAYHPSCTCK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 482 MGPasDPMAVVDPLTmKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGA 561
Cdd:PRK02106 480 MGT--DPMAVVDPEG-RVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDWPVRQRA 556


                 ....
gi 612673659 562 IEVK 565
Cdd:PRK02106 557 QRPR 560
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 9-542 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 893.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659    9 DYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAHARGK 88
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDYPWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   89 VLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAApyDKFRGHDGPIKLKRGPATNPLFQSFF 168
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPEGMESWDYADCLPYYKRLETTFGGE--KPYRGHDGPIKVRRGPADNPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  169 DAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKKNG-K 247
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFEGNRATGVEFKKGGrK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  248 LHTINANEVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLDIKRMPF 327
Cdd:TIGR01810 239 EHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPVSLYPSLNWLKQPF 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  328 IGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKIKSKDPF 407
Cdd:TIGR01810 319 IGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSNSRGHVKIKSKDPF 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  408 EKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAKMGPASD 487
Cdd:TIGR01810 399 EKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETALHPCGTCKMGPASD 478

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 612673659  488 PMAVVDPLTmKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPL 542
Cdd:TIGR01810 479 EMSVVDPET-RVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 5-542 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 752.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   5 NKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDyfWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAH 84
Cdd:COG2303    2 LEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRD--DDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  85 ARGKVLGGSSSINGMIYQRGNPMDYEGWAEpEGMETWDFAHCLPYFKKLEKTYGAApyDKFRGHDGPIKLKRGPATNPLF 164
Cdd:COG2303   80 PRGKVLGGSSSINGMIYVRGQPEDFDLWAQ-LGNQGWGYDDVLPYFKRAEDNERGA--DAYHGRSGPLPVSDPPLPNPLS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 165 QSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKK 244
Cdd:COG2303  157 DAFIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFDGGRATGVEYRD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 245 NGKLHTINAN-EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLdik 323
Cdd:COG2303  237 DGEEHTVRAArEVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLNKSL--- 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 324 RMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRY-DGQKAAV-AHGYQVHVGPMYSNSRGSLKI 401
Cdd:COG2303  314 RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALHdGHGFTAHVEQLRPESRGRVTL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 402 KSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEiLDWVRRDGETALHPSCSAK 481
Cdd:COG2303  394 DSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARAYTIYHPVGTCR 472

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673659 482 MGPasDPMAVVDPlTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPL 542
Cdd:COG2303  473 MGT--DPDSVVDP-RLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGDYLK 530
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 78-303 9.18e-50

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 171.31  E-value: 9.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   78 GGRKVAHARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAAPydkfrghdgpiklkRG 157
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEFGLEGWGYDDYLPYMDKVEGPLGVTT--------------KG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  158 PATNPLFQSFFDAGVEAGYHKTP---DVNGFRQEGFGPFdsQVHRGRRMSASRAYLHPAMKRkNLTVETRAFVTEIHYEG 234
Cdd:pfam00732  81 IEESPLNQALLKAAEELGYPVEAvprNSNGCHYCGFCGL--GCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIILG 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612673659  235 R--RATGVTYKKNGKLHT---INANEVILSGGAFNTPQLLQLSGIGDSEflkskgieprvHlpGVGENFEDHLE 303
Cdd:pfam00732 158 RggRAVGVEARDGGGGIKrliTAAKEVVVAAGALNTPPLLLRSGLGKNP-----------H--PVGKNLQLHPV 218
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 4-565 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1050.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   4 KNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVA 83
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDYRWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  84 HARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGaaPYDKFRGHDGPIKLKRG-PATNP 162
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELPGLEGWSYADCLPYFKKAETRDG--GEDDYRGGDGPLSVTRGkPGTNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 163 LFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTY 242
Cdd:PRK02106 160 LFQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFEGKRAVGVEY 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 243 KKNGKLHTINAN-EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLD 321
Cdd:PRK02106 240 ERGGGRETARARrEVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPVSLYPALK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 322 IKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKI 401
Cdd:PRK02106 320 WWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSPSRGSVKL 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 402 KSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAK 481
Cdd:PRK02106 400 KSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAYHPSCTCK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 482 MGPasDPMAVVDPLTmKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGA 561
Cdd:PRK02106 480 MGT--DPMAVVDPEG-RVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDWPVRQRA 556


                 ....
gi 612673659 562 IEVK 565
Cdd:PRK02106 557 QRPR 560
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 9-542 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 893.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659    9 DYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAHARGK 88
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDYPWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   89 VLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAApyDKFRGHDGPIKLKRGPATNPLFQSFF 168
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPEGMESWDYADCLPYYKRLETTFGGE--KPYRGHDGPIKVRRGPADNPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  169 DAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKKNG-K 247
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFEGNRATGVEFKKGGrK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  248 LHTINANEVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLDIKRMPF 327
Cdd:TIGR01810 239 EHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPVSLYPSLNWLKQPF 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  328 IGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKIKSKDPF 407
Cdd:TIGR01810 319 IGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSNSRGHVKIKSKDPF 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  408 EKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAKMGPASD 487
Cdd:TIGR01810 399 EKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETALHPCGTCKMGPASD 478

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 612673659  488 PMAVVDPLTmKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPL 542
Cdd:TIGR01810 479 EMSVVDPET-RVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 5-542 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 752.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   5 NKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDyfWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAH 84
Cdd:COG2303    2 LEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRD--DDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  85 ARGKVLGGSSSINGMIYQRGNPMDYEGWAEpEGMETWDFAHCLPYFKKLEKTYGAApyDKFRGHDGPIKLKRGPATNPLF 164
Cdd:COG2303   80 PRGKVLGGSSSINGMIYVRGQPEDFDLWAQ-LGNQGWGYDDVLPYFKRAEDNERGA--DAYHGRSGPLPVSDPPLPNPLS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 165 QSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKK 244
Cdd:COG2303  157 DAFIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFDGGRATGVEYRD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 245 NGKLHTINAN-EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLdik 323
Cdd:COG2303  237 DGEEHTVRAArEVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLNKSL--- 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 324 RMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRY-DGQKAAV-AHGYQVHVGPMYSNSRGSLKI 401
Cdd:COG2303  314 RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALHdGHGFTAHVEQLRPESRGRVTL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 402 KSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEiLDWVRRDGETALHPSCSAK 481
Cdd:COG2303  394 DSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARAYTIYHPVGTCR 472

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673659 482 MGPasDPMAVVDPlTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPL 542
Cdd:COG2303  473 MGT--DPDSVVDP-RLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGDYLK 530
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 78-303 9.18e-50

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 171.31  E-value: 9.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   78 GGRKVAHARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAAPydkfrghdgpiklkRG 157
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEFGLEGWGYDDYLPYMDKVEGPLGVTT--------------KG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  158 PATNPLFQSFFDAGVEAGYHKTP---DVNGFRQEGFGPFdsQVHRGRRMSASRAYLHPAMKRkNLTVETRAFVTEIHYEG 234
Cdd:pfam00732  81 IEESPLNQALLKAAEELGYPVEAvprNSNGCHYCGFCGL--GCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIILG 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612673659  235 R--RATGVTYKKNGKLHT---INANEVILSGGAFNTPQLLQLSGIGDSEflkskgieprvHlpGVGENFEDHLE 303
Cdd:pfam00732 158 RggRAVGVEARDGGGGIKrliTAAKEVVVAAGALNTPPLLLRSGLGKNP-----------H--PVGKNLQLHPV 218
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 394-532 2.43e-42

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 148.70  E-value: 2.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  394 NSRGSLKIKSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILsqKAMDPFNGGEISPGPE-------VQTDEEILDWV 466
Cdd:pfam05199   2 RSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRIL--AAAGLVLGVELTPGPVpevsdaaVTSDDELLAYI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612673659  467 RRDGETALHPSCSAKMGPASDPmAVVDPlTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKA 532
Cdd:pfam05199  80 RAAASTSYHPMGTCRMGADPDD-AVVDP-DLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAERA 143
PLN02785 PLN02785
Protein HOTHEAD
 2-539 3.91e-24

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 106.43  E-value: 3.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659   2 SNKNKSYDYVIIGGGSAGSVLGNRLSEDKdkEVLVLEAGRSDY------FWDLFiqmPAALMFPSGNKFYDWIYSTDeep 75
Cdd:PLN02785  50 SGGDSAYDYIVVGGGTAGCPLAATLSQNF--SVLLLERGGVPFgnanvsFLENF---HIGLADTSPTSASQAFISTD--- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659  76 hmggrKVAHARGKVLGGSSSINGMIYQRGNP--MDYEGWAEpegmetwdfahclpyfKKLEKTYgaaPYDKFRGHDGPik 153
Cdd:PLN02785 122 -----GVINARARVLGGGTCINAGFYSRASTrfIQKAGWDA----------------KLVNESY---PWVERQIVHWP-- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 154 lKRGPATNPLFQSFFDAGVeagyhkTPdVNGFRQE-------GFGPFDsqvHRGRRMSAsrAYLHPAMKRKNLTVETRAF 226
Cdd:PLN02785 176 -KVAPWQAALRDSLLEVGV------SP-FNGFTYDhvygtkvGGTIFD---EFGRRHTA--AELLAAGNPNKLRVLLHAT 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 227 VTEIHY--EGR--RATGVTYK-KNGKLHT--INAN---EVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGE 296
Cdd:PLN02785 243 VQKIVFdtSGKrpRATGVIFKdENGNQHQafLSNNkgsEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPVVLHNEHVGK 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 297 NFEDHLEVYIQHKCKEPV--SLQPSLDIKRM-PFIglqwiftrtgAAASnhfeggGFVRSNNEVDYPNLM-------FHF 366
Cdd:PLN02785 323 GMADNPMNSIFVPSKAPVeqSLIQTVGITKMgVYI----------EASS------GFGQSPDSIHCHHGImsaeigqLST 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 367 LP------------IAVRYDGQKAAVAHGYQVH--VGPMysnSRGSLKIKSKDPFEKPSIRFNYLSTEEDKKEWVEAIRV 432
Cdd:PLN02785 387 IPpkqrtpeaiqayIHRKKNLPHEAFNGGFILEkiAGPI---STGHLSLINTNVDDNPSVTFNYFKHPQDLQRCVYGIRT 463

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 433 ARNILSQKAMDPFNGGE---------------ISPGPEVQTDEEILDWVRRDGETAL---HPSCSAKmgpasdpmAVVDP 494
Cdd:PLN02785 464 IEKIVKTNHFTNFTQCDkqtmekvlnmsvkanINLIPKHTNDTKSLEQFCKDTVITIwhyHGGCHVG--------KVVDQ 535

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 612673659 495 lTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAE-KAADIIRGR 539
Cdd:PLN02785 536 -NYKVLGVSRLRVIDGSTFDESPGTNPQATVMMMGRyMGVKILRER 580
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 210-262 1.96e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 44.05  E-value: 1.96e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612673659 210 LHPAMKRKNLTVETRAFVTEIHYEGRRATGVT-YKKNGKLHTINANEVIL-SGGA 262
Cdd:COG1053  140 LYQAALRLGVEIFTETEVLDLIVDDGRVVGVVaRDRTGEIVRIRAKAVVLaTGGF 194
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 5-38 7.77e-04

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 42.15  E-value: 7.77e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 612673659   5 NKSYDYVIIGGGSAGSVLGNRLSeDKDKEVLVLE 38
Cdd:PTZ00367  31 NYDYDVIIVGGSIAGPVLAKALS-KQGRKVLMLE 63
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
197-286 8.25e-04

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 41.64  E-value: 8.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673659 197 VHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGrRATGVTYK--KNGKLHTINANEVILSGGAfntpqllqlsgI 274
Cdd:COG0492  170 IHRRDELRASKILVERLRANPKIEVLWNTEVTEIEGDG-RVEGVTLKnvKTGEEKELEVDGVFVAIGL-----------K 237

                         90
                 ....*....|..
gi 612673659 275 GDSEFLKSKGIE 286
Cdd:COG0492  238 PNTELLKGLGLE 249
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
5-39 1.03e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 41.67  E-value: 1.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 612673659   5 NKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEA 39
Cdd:COG0579    2 MEMYDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 5-41 9.17e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 38.53  E-value: 9.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 612673659   5 NKSYDYVIIGGGSAGSVLGNRLSEdKDKEVLVLEAGR 41
Cdd:COG1249    1 MKDYDLVVIGAGPGGYVAAIRAAQ-LGLKVALVEKGR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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