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Conserved domains on  [gi|612673048|gb|EZS89114|]
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23S rRNA (uracil-5-)-methyltransferase RumA [Staphylococcus aureus VET0159R]

Protein Classification

class I SAM-dependent RNA methyltransferase( domain architecture ID 11455144)

class I SAM-dependent RNA methyltransferase catalyzes the methylation of a specific RNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0001510|GO:0046872|GO:0008757|GO:1904047
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-450 1.42e-176

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 498.93  E-value: 1.42e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   8 DIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQH 87
Cdd:COG2265    1 EILELTIEDLAHGGDGVARHDGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQLQH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  88 LSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGkNEQNEVIMGFYRQRSHDIIDMESCLIQDS 167
Cdd:COG2265   81 LSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVR-RTDGRLRLGFYARGSHELVDIDECPLLDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 168 QHQEVMNKVKSILKDLNvsiyqeqLKKGLMRHLVVRTGyhtdemmvifvtngkkwpqknavvekildafpnvtsikqnin 247
Cdd:COG2265  160 ALNALLPALRELLAELG-------ARRGELRHLVVRAG------------------------------------------ 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 248 dshsnvimgrqsitlygKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAP 327
Cdd:COG2265  191 -----------------RDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLAR 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 328 HAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWkAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIV 407
Cdd:COG2265  254 RAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPEL-LWGGRPDVVVLDPPRAGAGPEVLEALAALGPRRIV 332

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 612673048 408 YISCNPATQQRD-ALLLSEKYQLEEVTPVDMFPQTTHVETVALF 450
Cdd:COG2265  333 YVSCNPATLARDlALLVEGGYRLEKVQPVDMFPHTHHVESVALL 376
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-450 1.42e-176

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 498.93  E-value: 1.42e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   8 DIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQH 87
Cdd:COG2265    1 EILELTIEDLAHGGDGVARHDGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQLQH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  88 LSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGkNEQNEVIMGFYRQRSHDIIDMESCLIQDS 167
Cdd:COG2265   81 LSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVR-RTDGRLRLGFYARGSHELVDIDECPLLDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 168 QHQEVMNKVKSILKDLNvsiyqeqLKKGLMRHLVVRTGyhtdemmvifvtngkkwpqknavvekildafpnvtsikqnin 247
Cdd:COG2265  160 ALNALLPALRELLAELG-------ARRGELRHLVVRAG------------------------------------------ 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 248 dshsnvimgrqsitlygKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAP 327
Cdd:COG2265  191 -----------------RDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLAR 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 328 HAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWkAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIV 407
Cdd:COG2265  254 RAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPEL-LWGGRPDVVVLDPPRAGAGPEVLEALAALGPRRIV 332

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 612673048 408 YISCNPATQQRD-ALLLSEKYQLEEVTPVDMFPQTTHVETVALF 450
Cdd:COG2265  333 YVSCNPATLARDlALLVEGGYRLEKVQPVDMFPHTHHVESVALL 376
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 17-445 2.66e-173

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 492.80  E-value: 2.66e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   17 LTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEM 96
Cdd:TIGR00479   1 LDHQGEGVARFNGKTVFVPGALPGEKAEVRVTEVKKQYARARVKKILEDSPERTTPPCPHFGQCGGCQLQHLSYELQLRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   97 KKEQVINLFQRKAHFDNSKIND--TVGmTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMN 174
Cdd:TIGR00479  81 KQQQVIALLERIGKFVSEPIEDvpTIG-DDPWGYRNKARLSLGRSPSGQLQAGFYQKGSHDIVDVKQCPVQAPALNALLP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  175 KVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGKKWPQKNAVVEKILDAFPNVTSIKQNINDSHSNVI 254
Cdd:TIGR00479 160 KVRAILENFGASRYLEHKELGQARHGVLRIGRHTGELSSVDRTALERFPHKEELDLYLQPDSPDVKSICQNINPEKTNVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  255 MGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYG 334
Cdd:TIGR00479 240 FGEETEVIAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  335 VEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPA 414
Cdd:TIGR00479 320 VEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPKQPWAGNGFDKVLLDPPRKGCAAGVLRTIIKLKPERIVYVSCNPA 399

                         410       420       430
                  ....*....|....*....|....*....|..
gi 612673048  415 TQQRDA-LLLSEKYQLEEVTPVDMFPQTTHVE 445
Cdd:TIGR00479 400 TLARDLeALCKAGYTIARVQPVDMFPHTGHVE 431
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
13-450 1.46e-85

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 268.95  E-value: 1.46e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  13 TVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEA 92
Cdd:PRK13168  19 TIESLDHDGRGVARHNGKTVFIEGALPGERVEVQVTEDKKQYARAKVVRILKPSPERVTPRCPHFGVCGGCQLQHLSIDA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  93 QLEMKKEQVINLFQRKAHFDNSKINDTVgMTDPWRYRNKSQIPVGKNE-QNEVIMGFYRQRSHDIIDMESCLIQDSQHQE 171
Cdd:PRK13168  99 QIASKQRALEDLLKHLAGVEPEEVLPPI-AGPPWGYRRRARLSVRYVPkKGQLLVGFREKNSSDIVDIDQCPVLVPPLSA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 172 VMNKVKSILKDLnvSIYQEqlkkglMRH-----------LVVRtgyHTDEMmvifvtngkkwpqkNAVVEKILDAFpnvt 240
Cdd:PRK13168 178 LLPPLRALLSSL--SAKRR------LGHvelaqgdngtaLVLR---HLEPL--------------SEADRAKLRAF---- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 241 SIKQNI------NDSHSNVIMGRQSITL-YGKDtiIDQLTdSTFKISDqsFYQINSEQTEKLYNKAIEYAELTGNEVVLD 313
Cdd:PRK13168 229 AEQHGLqlylqpKGPDLVHLLGPADAQLsYYLP--EFGLR-LAFSPRD--FIQVNAQVNQKMVARALEWLDPQPGDRVLD 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 314 TYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQ--WKAQGIkpDVVMVDPPRKGCD 391
Cdd:PRK13168 304 LFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANLEEDFTDqpWALGGF--DKVLLDPPRAGAA 381

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 392 ETfIQTLLTLEPKRIVYISCNPATQQRDALLLSEK-YQLEEVTPVDMFPQTTHVETVALF 450
Cdd:PRK13168 382 EV-MQALAKLGPKRIVYVSCNPATLARDAGVLVEAgYRLKRAGMLDMFPHTGHVESMALF 440
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 89-446 3.40e-20

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 91.35  E-value: 3.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   89 SYEAQLEMKKEQVINLFqrkAHFDNSKINdtVGMTDPWRYRNKSQIPVGkNEQNEVIMGFYRQRSHDIIDMESCLIQDSQ 168
Cdd:pfam05958   1 QYDAQLAEKKSRLKALF---APFYAPDPE--VFASPDKHYRMRAEFRIW-HEGDDLYYAMFDQQTKSRIRVDQFPAASEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  169 HQEVMNKVKSILKD---LNVSIYQEQLKKGLMRHLVVRTGYH---TDEmmvifvtngkkWPQ-----KNAVVEKILDAFP 237
Cdd:pfam05958  75 INELMPALIAALRQdpaLRHKLFQVDFLTTLSGEALVSLLYHkqlDDE-----------WRQaaealRDALRAQGLDVNL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  238 NVTSIKQNINDSHSNVimgRQSITLYGKDTIIDQLTDStfkisdqsFYQINSEQTEKLYNKAIEYAELTGNEVvLDTYCG 317
Cdd:pfam05958 144 IGRARKQKIVLDQDYV---DETLPVAGREFIYRQVENS--------FTQPNAAVNIKMLEWACDVTQGSKGDL-LELYCG 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  318 TGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKA-------QGIKPD-----VVMVDP 385
Cdd:pfam05958 212 NGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAEEFTQAMNGvrefnrlKGIDLKsyncsTIFVDP 291

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673048  386 PRKGCDETFIQTLLTLEpkRIVYISCNPATQQRDALLLSEKYQLEEVTPVDMFPQTTHVET 446
Cdd:pfam05958 292 PRAGLDPETLKLVQAYP--RILYISCNPETLCANLEQLSKTHRVERFALFDQFPYTHHMEC 350
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 311-411 1.29e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 311 VLDTYCGTGTIGLYMAPH-AKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILqwkAQGIKPDVVMVDPP--- 386
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP---EADESFDVIISDPPlhh 78

                         90       100
                 ....*....|....*....|....*.
gi 612673048 387 -RKGCDETFIQTLLTLEPKRIVYISC 411
Cdd:cd02440   79 lVEDLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-450 1.42e-176

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 498.93  E-value: 1.42e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   8 DIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQH 87
Cdd:COG2265    1 EILELTIEDLAHGGDGVARHDGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQLQH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  88 LSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGkNEQNEVIMGFYRQRSHDIIDMESCLIQDS 167
Cdd:COG2265   81 LSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVR-RTDGRLRLGFYARGSHELVDIDECPLLDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 168 QHQEVMNKVKSILKDLNvsiyqeqLKKGLMRHLVVRTGyhtdemmvifvtngkkwpqknavvekildafpnvtsikqnin 247
Cdd:COG2265  160 ALNALLPALRELLAELG-------ARRGELRHLVVRAG------------------------------------------ 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 248 dshsnvimgrqsitlygKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAP 327
Cdd:COG2265  191 -----------------RDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLAR 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 328 HAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWkAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIV 407
Cdd:COG2265  254 RAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPEL-LWGGRPDVVVLDPPRAGAGPEVLEALAALGPRRIV 332

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 612673048 408 YISCNPATQQRD-ALLLSEKYQLEEVTPVDMFPQTTHVETVALF 450
Cdd:COG2265  333 YVSCNPATLARDlALLVEGGYRLEKVQPVDMFPHTHHVESVALL 376
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 17-445 2.66e-173

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 492.80  E-value: 2.66e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   17 LTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEM 96
Cdd:TIGR00479   1 LDHQGEGVARFNGKTVFVPGALPGEKAEVRVTEVKKQYARARVKKILEDSPERTTPPCPHFGQCGGCQLQHLSYELQLRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   97 KKEQVINLFQRKAHFDNSKIND--TVGmTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMN 174
Cdd:TIGR00479  81 KQQQVIALLERIGKFVSEPIEDvpTIG-DDPWGYRNKARLSLGRSPSGQLQAGFYQKGSHDIVDVKQCPVQAPALNALLP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  175 KVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGKKWPQKNAVVEKILDAFPNVTSIKQNINDSHSNVI 254
Cdd:TIGR00479 160 KVRAILENFGASRYLEHKELGQARHGVLRIGRHTGELSSVDRTALERFPHKEELDLYLQPDSPDVKSICQNINPEKTNVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  255 MGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYG 334
Cdd:TIGR00479 240 FGEETEVIAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTFTLPLAKQAKSVVG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  335 VEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPA 414
Cdd:TIGR00479 320 VEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPKQPWAGNGFDKVLLDPPRKGCAAGVLRTIIKLKPERIVYVSCNPA 399

                         410       420       430
                  ....*....|....*....|....*....|..
gi 612673048  415 TQQRDA-LLLSEKYQLEEVTPVDMFPQTTHVE 445
Cdd:TIGR00479 400 TLARDLeALCKAGYTIARVQPVDMFPHTGHVE 431
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
13-450 1.46e-85

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 268.95  E-value: 1.46e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  13 TVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEA 92
Cdd:PRK13168  19 TIESLDHDGRGVARHNGKTVFIEGALPGERVEVQVTEDKKQYARAKVVRILKPSPERVTPRCPHFGVCGGCQLQHLSIDA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  93 QLEMKKEQVINLFQRKAHFDNSKINDTVgMTDPWRYRNKSQIPVGKNE-QNEVIMGFYRQRSHDIIDMESCLIQDSQHQE 171
Cdd:PRK13168  99 QIASKQRALEDLLKHLAGVEPEEVLPPI-AGPPWGYRRRARLSVRYVPkKGQLLVGFREKNSSDIVDIDQCPVLVPPLSA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 172 VMNKVKSILKDLnvSIYQEqlkkglMRH-----------LVVRtgyHTDEMmvifvtngkkwpqkNAVVEKILDAFpnvt 240
Cdd:PRK13168 178 LLPPLRALLSSL--SAKRR------LGHvelaqgdngtaLVLR---HLEPL--------------SEADRAKLRAF---- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 241 SIKQNI------NDSHSNVIMGRQSITL-YGKDtiIDQLTdSTFKISDqsFYQINSEQTEKLYNKAIEYAELTGNEVVLD 313
Cdd:PRK13168 229 AEQHGLqlylqpKGPDLVHLLGPADAQLsYYLP--EFGLR-LAFSPRD--FIQVNAQVNQKMVARALEWLDPQPGDRVLD 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 314 TYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQ--WKAQGIkpDVVMVDPPRKGCD 391
Cdd:PRK13168 304 LFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANLEEDFTDqpWALGGF--DKVLLDPPRAGAA 381

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 392 ETfIQTLLTLEPKRIVYISCNPATQQRDALLLSEK-YQLEEVTPVDMFPQTTHVETVALF 450
Cdd:PRK13168 382 EV-MQALAKLGPKRIVYVSCNPATLARDAGVLVEAgYRLKRAGMLDMFPHTGHVESMALF 440
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
193-449 7.68e-44

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 156.18  E-value: 7.68e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 193 KKGLMRHLVVRTGYHTDEMMVIFVTNGKKW-PQKNAVVEKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQ 271
Cdd:PRK03522  58 KRGELKYILLTESQSDGELMLRFVLRSETKlARLRRALPWLQAQLPQLKVISVNIQPVHMAILEGEEEIFLTEQQALPER 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 272 LTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATI 351
Cdd:PRK03522 138 FNGVPLFIRPQSFFQTNPAVAAQLYATARDWVRELPPRSMWDLFCGVGGFGLHCATPGMQLTGIEISAEAIACAKQSAAE 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 352 NQCNNTTFVCGKAEEVILqwkAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDALLLSEkYQLEE 431
Cdd:PRK03522 218 LGLTNVQFQALDSTQFAT---AQGEVPDLVLVNPPRRGIGKELCDYLSQMAPRFILYSSCNAQTMAKDLAHLPG-YRIER 293

                        250
                 ....*....|....*...
gi 612673048 432 VTPVDMFPQTTHVETVAL 449
Cdd:PRK03522 294 VQLFDMFPHTAHYEVLTL 311
meth_trns_rumB TIGR02085
23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases ...
 74-449 1.34e-41

23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases designated RumB, formerly YbjF. Members act on 23S rRNA U747 and the equivalent position in other proteobacterial species. This family is homologous to the other 23S rRNA methyltransferase RumA and to the tRNA methyltransferase TrmA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 131140  Cd Length: 374  Bit Score: 151.53  E-value: 1.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   74 CIYYE--RCGGCQLQHLSYEAQLEMKKEQVINLFqrKAHFDNSKINDTVGMTDPwRYRNKSQIPV-GKNEQNevIMGFYr 150
Cdd:TIGR02085   2 CAFYIqgRCRSCQWLAQPYSEQLTNKQQHLKELL--APNATVVQWLAPVTSAEQ-AFRNKAKMVVsGSVERP--ILGIL- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  151 QRSHDIIDMESCLIQDSQHQEVMNKVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGK-KWPQKNAVV 229
Cdd:TIGR02085  76 HRDGTPLDLCDCPLYPQSFQPVFAYLKNFIARAGLTPYNVAKKKGELKFILLTESENSGQLMLRFVLRSEtKLAQIRRAL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  230 EKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAELTGNE 309
Cdd:TIGR02085 156 PWLIEQLPQLEVISVNIQPVHMAILEGEEEIFLTEQQALPERFNDVPLVIRPQSFFQTNPKVAAQLYATARQWVREIPVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  310 VVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVIlqwKAQGIKPDVVMVDPPRKG 389
Cdd:TIGR02085 236 QMWDLFCGVGGFGLHCAGPDTQLTGIEIESEAIACAQQSAQMLGLDNLSFAALDSAKFA---TAQMSAPELVLVNPPRRG 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  390 CDETFIQTLLTLEPKRIVYISCNPATQQRDALLLSeKYQLEEVTPVDMFPQTTHVETVAL 449
Cdd:TIGR02085 313 IGKELCDYLSQMAPKFILYSSCNAQTMAKDIAELS-GYQIERVQLFDMFPHTSHYEVLTL 371
PRK05031 PRK05031
tRNA (uracil-5-)-methyltransferase; Validated
 80-446 2.14e-28

tRNA (uracil-5-)-methyltransferase; Validated


Pssm-ID: 235332  Cd Length: 362  Bit Score: 114.93  E-value: 2.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  80 CGGCQLQHLSYEAQLEMKKEQVINLFqrkAHFDNSKIndTVGMTDPWRYRNKSQIPVGKnEQNEV--IMgfYRQRSHDII 157
Cdd:PRK05031   1 MTPECLPPEQYEAQLAEKVARLKELF---APFSAPEP--EVFRSPPSHYRMRAEFRIWH-EGDDLyyAM--FDQQTKQRI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 158 DMESCLIQDSQHQEVMNKVKSILKD---LNVSIYQEQLKKGLMRHLVVRTGYH---TDEmmvifvtngkkWpQKNAvvEK 231
Cdd:PRK05031  73 RIDQFPIASELINALMPALLAALRAnpvLRHKLFQVDFLSTLSGEILVSLLYHkklDEE-----------W-EQAA--KA 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 232 ILDAFPNVTsikqnindshsnvIMGR---QSITLyGKDTIIDQLT----DSTFKISDQSFYQINSEQTEKLYNKAIEYAE 304
Cdd:PRK05031 139 LRDALFNVH-------------LIGRsrkQKIVL-DQDYVDERLPvagrEFIYRQVENSFTQPNAAVNEKMLEWALDATK 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 305 -LTGNevVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWK-------AQGI 376
Cdd:PRK05031 205 gSKGD--LLELYCGNGNFTLALARNFRRVLATEISKPSVAAAQYNIAANGIDNVQIIRMSAEEFTQAMNgvrefnrLKGI 282

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612673048 377 K-----PDVVMVDPPRKGCDET---FIQtlltlEPKRIVYISCNPATQQRDALLLSEKYQLEEVTPVDMFPQTTHVET 446
Cdd:PRK05031 283 DlksynFSTIFVDPPRAGLDDEtlkLVQ-----AYERILYISCNPETLCENLETLSQTHKVERFALFDQFPYTHHMEC 355
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 89-446 3.40e-20

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 91.35  E-value: 3.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048   89 SYEAQLEMKKEQVINLFqrkAHFDNSKINdtVGMTDPWRYRNKSQIPVGkNEQNEVIMGFYRQRSHDIIDMESCLIQDSQ 168
Cdd:pfam05958   1 QYDAQLAEKKSRLKALF---APFYAPDPE--VFASPDKHYRMRAEFRIW-HEGDDLYYAMFDQQTKSRIRVDQFPAASEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  169 HQEVMNKVKSILKD---LNVSIYQEQLKKGLMRHLVVRTGYH---TDEmmvifvtngkkWPQ-----KNAVVEKILDAFP 237
Cdd:pfam05958  75 INELMPALIAALRQdpaLRHKLFQVDFLTTLSGEALVSLLYHkqlDDE-----------WRQaaealRDALRAQGLDVNL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  238 NVTSIKQNINDSHSNVimgRQSITLYGKDTIIDQLTDStfkisdqsFYQINSEQTEKLYNKAIEYAELTGNEVvLDTYCG 317
Cdd:pfam05958 144 IGRARKQKIVLDQDYV---DETLPVAGREFIYRQVENS--------FTQPNAAVNIKMLEWACDVTQGSKGDL-LELYCG 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  318 TGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKA-------QGIKPD-----VVMVDP 385
Cdd:pfam05958 212 NGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAEEFTQAMNGvrefnrlKGIDLKsyncsTIFVDP 291

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673048  386 PRKGCDETFIQTLLTLEpkRIVYISCNPATQQRDALLLSEKYQLEEVTPVDMFPQTTHVET 446
Cdd:pfam05958 292 PRAGLDPETLKLVQAYP--RILYISCNPETLCANLEQLSKTHRVERFALFDQFPYTHHMEC 350
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 311-411 1.29e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 311 VLDTYCGTGTIGLYMAPH-AKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILqwkAQGIKPDVVMVDPP--- 386
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP---EADESFDVIISDPPlhh 78

                         90       100
                 ....*....|....*....|....*.
gi 612673048 387 -RKGCDETFIQTLLTLEPKRIVYISC 411
Cdd:cd02440   79 lVEDLARFLEEARRLLKPGGVLVLTL 104
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 311-386 9.10e-10

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 60.20  E-value: 9.10e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612673048 311 VLDTYCGTGTIGLYMAPH-AKHVYGVEVVPSAIEDAQQNATINQCNNT-TFVCGKAEEVILQWKAQGIKPDVVMVDPP 386
Cdd:COG1092  220 VLNLFSYTGGFSVHAAAGgAKSVTSVDLSATALEWAKENAALNGLDDRhEFVQADAFDWLRELAREGERFDLIILDPP 297
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
296-384 2.34e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 54.66  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 296 YNKAIEYAELTGnEVVLDTYCGTGTIGLYMAPH-AKHVYGVEVVPSAIEDAQQNATINQCN-NTTFVCGKAEEVILQWKA 373
Cdd:COG4076   25 FKAAIERVVKPG-DVVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADATDLDLPEKA 103

                         90
                 ....*....|....
gi 612673048 374 qgikpDVV---MVD 384
Cdd:COG4076  104 -----DVIiseMLD 112
COG3269 COG3269
Predicted RNA-binding protein, contains TRAM domain [General function prediction only];
13-60 5.57e-08

Predicted RNA-binding protein, contains TRAM domain [General function prediction only];


Pssm-ID: 442500 [Multi-domain]  Cd Length: 129  Bit Score: 51.21  E-value: 5.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 612673048  13 TVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL 60
Cdd:COG3269   79 EIEDIGKKGDGIARVEGFVIFVPGAEVGDRVKVKITKVKRNFAFAEVV 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 295-366 2.36e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.99  E-value: 2.36e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612673048 295 LYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATiNQCNNTTFVCGKAEE 366
Cdd:COG2226   10 GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAA-EAGLNVEFVVGDAED 80
PRK14968 PRK14968
putative methyltransferase; Provisional
 289-357 1.04e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 48.74  E-value: 1.04e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612673048 289 SEQTEKLynkaIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNT 357
Cdd:PRK14968   9 AEDSFLL----AENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNN 73
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
307-409 1.73e-06

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 48.00  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  307 GNEVVLDTYCGTGTIGLYMAPH-AKHVYGVEVVPSAIEDAQQNATINQCNNTTFVcGKAEEVILQWKAQGIKPDVVMVDP 385
Cdd:pfam03602  41 EGARVLDLFAGSGALGLEALSRgAKRVTLVEKDKRAVQILKENLQLLGLPGAVLV-MDALLALLRLAGKGPVFDIVFLDP 119

                          90       100
                  ....*....|....*....|....*...
gi 612673048  386 P-RKGCDETFIQTLLT---LEPKRIVYI 409
Cdd:pfam03602 120 PyAKGLIEEVLDLLAEkgwLKPNALIYV 147
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 302-386 1.75e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 48.99  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 302 YAELTGNEVVLDTYCGTGTIGLYMAP--HAKHVYGVEVVPSAIEDAQQNATINQCNN-TTFVCGKAEEVILQWKAQGIkp 378
Cdd:COG4123   32 FAPVKKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELPPGSF-- 109


                 ....*...
gi 612673048 379 DVVMVDPP 386
Cdd:COG4123  110 DLVVSNPP 117
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 303-386 1.99e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 47.64  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 303 AELTGNEVVLDTYCGTGTI---GLYMAPhakHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKaqgiKPD 379
Cdd:COG1041   22 AGAKEGDTVLDPFCGTGTIlieAGLLGR---RVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADE----SVD 94


                 ....*..
gi 612673048 380 VVMVDPP 386
Cdd:COG1041   95 AIVTDPP 101
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 297-366 9.83e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 9.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673048 297 NKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAK-HVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEE 366
Cdd:COG0500   16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAE 86
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 300-360 1.03e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 45.95  E-value: 1.03e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612673048 300 IEYAELTGNEVVLDTYCGTGTIGLYMA---PHAkHVYGVEVVPSAIEDAQQNATINQCNNTTFV 360
Cdd:COG2813   42 LEHLPEPLGGRVLDLGCGYGVIGLALAkrnPEA-RVTLVDVNARAVELARANAAANGLENVEVL 104
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 305-427 1.32e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.10  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  305 LTGNEVVLDTYCGTGTIGLYMA----PHAkHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIkpDV 380
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeelgPNA-EVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEDDKF--DV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 612673048  381 V--------MVDPprkgcDETF--IQTLLTlEPKRIVYISCNPATQQRDALLLSEKY 427
Cdd:pfam13847  78 VisncvlnhIPDP-----DKVLqeILRVLK-PGGRLIISDPDSLAELPAHVKEDSTY 128
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 299-383 1.42e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 47.08  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 299 AIEYAELTGNEVVLDTYCGTGTIGLYMA---PHAKhVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAqg 375
Cdd:COG2242  239 TLAKLALRPGDVLWDIGAGSGSVSIEAArlaPGGR-VYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALADLPD-- 315


                 ....*...
gi 612673048 376 ikPDVVMV 383
Cdd:COG2242  316 --PDAVFI 321
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 316-366 1.56e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.32  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 612673048  316 CGTGTIGLYMAPHAK-HVYGVEVVPSAIEDAQQNATINQCnNTTFVCGKAEE 366
Cdd:pfam13649   6 CGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAED 56
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
297-367 2.49e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 45.66  E-value: 2.49e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612673048 297 NKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQnaTINQCNNTTFVCGKAEEV 367
Cdd:PRK14896  19 DRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRD--DEIAAGNVEIIEGDALKV 87
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 262-382 2.52e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 45.04  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  262 LYGKDTI-IDQLTDSTFKI--SDQSFYQINSEQTEKLYNKAIEyaeltgNEVVLDTYCGTGTIGLYMAPHAK--HVYGVE 336
Cdd:pfam02475  57 LAGSDTEtIHKENGCRFKVdvAKVYWSPRLIAERERIAKLVEP------GEVVVDMFAGIGPFSIPIAKHSKarRVYAIE 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 612673048  337 VVPSAIEDAQQNATINQCNNTTF-VCGKAEEVILQWKAQgikpDVVM 382
Cdd:pfam02475 131 LNPESYKYLKENIKLNKVEDVVKpILGDVREVILEDVAD----RVVM 173
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 311-367 4.63e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 42.70  E-value: 4.63e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612673048 311 VLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNAtinQCNNTTFVCGKAEEV 367
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA---AELNVDFVQGDLEDL 81
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
310-408 1.15e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.97  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 310 VVLDTYCGTGTIGLYMA-PHAKHVYGVEVVPSAIEDAQQNAtINQCNNTTFVCGKAEEVILqwkaqGIKPDVVMVDPP-- 386
Cdd:COG2263   48 TVLDLGCGTGMLAIGAAlLGAKKVVGVDIDPEALEIARENA-ERLGVRVDFIRADVTRIPL-----GGSVDTVVMNPPfg 121

                         90       100
                 ....*....|....*....|....
gi 612673048 387 --RKGCDETFIQTllTLEPKRIVY 408
Cdd:COG2263  122 aqRRHADRPFLEK--ALEIAAVIY 143
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 310-409 2.07e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 41.99  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 310 VVLDTYCGTGTIGL-----YmaphAKHVYGVEVVPSAIEDAQQNA-TINQCNNTTFVCGKAEEVILQWKAQgiKPDVVMV 383
Cdd:COG0742   44 RVLDLFAGSGALGLealsrG----AASVVFVEKDRKAAAVIRKNLeKLGLEDRARVIRGDALRFLKRLAGE--PFDLVFL 117

                         90       100       110
                 ....*....|....*....|....*....|
gi 612673048 384 DPP-RKGCDETFIQTLLT---LEPKRIVYI 409
Cdd:COG0742  118 DPPyAKGLLEKALELLAEnglLAPGGLIVV 147
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 309-386 3.57e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 41.17  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048  309 EVVLDTYCGTG--TIGlyMAPHAKHVYGVEVVPSAIEDAQQNATI-NQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDP 385
Cdd:pfam09445   2 TRILDVFCGGGgnTIQ--FANVFDSVISIDINLEHLACAQHNAEVyGVSDRIWLIHGDWFELLAKLKFEKIKYDCVFASP 79


                  .
gi 612673048  386 P 386
Cdd:pfam09445  80 P 80
TRAM pfam01938
TRAM domain; This small domain has no known function. However it may perform a nucleic acid ...
 13-60 3.92e-04

TRAM domain; This small domain has no known function. However it may perform a nucleic acid binding role (Bateman A. unpublished observation).


Pssm-ID: 396497 [Multi-domain]  Cd Length: 59  Bit Score: 38.35  E-value: 3.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 612673048   13 TVVDLTHEGHGVVKIDR-FPIFIPQALINEQIEYKIIKVKKNFAIGKLL 60
Cdd:pfam01938  11 LVEGLSSNGEGIGRTDNgKVVFVPGALPGEFVEVKITKVKRNYLRGELL 59
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
293-347 6.43e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.75  E-value: 6.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612673048 293 EKLYNKAIEYAELTGNEVVLDTYCGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQ 347
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE 86
rsmD PRK10909
16S rRNA m(2)G966-methyltransferase; Provisional
 312-402 9.34e-04

16S rRNA m(2)G966-methyltransferase; Provisional


Pssm-ID: 236793  Cd Length: 199  Bit Score: 40.47  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612673048 312 LDTYCGTGTIGL-YMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAeeviLQWKAQGIKP-DVVMVDPP-RK 388
Cdd:PRK10909  58 LDCFAGSGALGLeALSRYAAGATLLEMDRAVAQQLIKNLATLKAGNARVVNTNA----LSFLAQPGTPhNVVFVDPPfRK 133

                         90
                 ....*....|....
gi 612673048 389 GCDEtfiQTLLTLE 402
Cdd:PRK10909 134 GLLE---ETINLLE 144
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 316-367 1.83e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.64  E-value: 1.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 612673048  316 CGTGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNAtinQCNNTTFVCGKAEEV 367
Cdd:pfam08241   5 CGTGLLTELLARLGARVTGVDISPEMLELAREKA---PREGLTFVVGDAEDL 53
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 311-386 3.16e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.34  E-value: 3.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612673048  311 VLDTYCGTGTIGLYMA---PHAkHVYGVEVVPSAIEDAQQNATINQCNNTTFVcgkAEEVILQWKAQgiKPDVVMVDPP 386
Cdd:pfam05175  35 VLDLGCGAGVLGAALAkesPDA-ELTMVDINARALESARENLAANGLENGEVV---ASDVYSGVEDG--KFDLIISNPP 107
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 299-368 7.18e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 37.85  E-value: 7.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612673048 299 AIEYAELTGNEVVLDTYCGTGTI----GLYMAPHAKhVYGVEVVPSAIEDAQQNA-TINQCNNTTFVCGKAEEVI 368
Cdd:PRK00377  32 ALSKLRLRKGDMILDIGCGTGSVtveaSLLVGETGK-VYAVDKDEKAINLTRRNAeKFGVLNNIVLIKGEAPEIL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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