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Conserved domains on  [gi|612663836|gb|EZS80059|]
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glucose-specific phosphotransferase enzyme IIA component [Staphylococcus aureus VET0191R]

Protein Classification

PTS glucose transporter subunit IIA( domain architecture ID 10005511)

PTS glucose transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming glucose substrates concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
14-158 3.51e-73

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


:

Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 216.53  E-value: 3.51e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  14 KDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQ 93
Cdd:COG2190    4 KTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVK 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612663836  94 LDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKGET 158
Cdd:COG2190   84 LNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTKSGQVKAGDP 148
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
14-158 3.51e-73

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 216.53  E-value: 3.51e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  14 KDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQ 93
Cdd:COG2190    4 KTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVK 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612663836  94 LDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKGET 158
Cdd:COG2190   84 LNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTKSGQVKAGDP 148
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
16-136 1.51e-62

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 188.36  E-value: 1.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   16 IAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLD 95
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 612663836   96 GEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIII 136
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 18-141 4.76e-56

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 172.09  E-value: 4.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  18 IYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGE 97
Cdd:cd00210    1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 612663836  98 GFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQ 141
Cdd:cd00210   81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 18-138 2.47e-54

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 167.42  E-value: 2.47e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   18 IYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGE 97
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 612663836   98 GFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITN 138
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 2-165 8.36e-46

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 147.43  E-value: 8.36e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   2 FKKLFGKGKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGL 81
Cdd:PRK09439   7 LKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  82 ELLVHIGLDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINiYDENAVIKGETKVI 161
Cdd:PRK09439  87 ELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELI-KLSGSVTAGETPVI 165


                 ....
gi 612663836 162 DVTM 165
Cdd:PRK09439 166 RVKK 169
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
14-158 3.51e-73

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 216.53  E-value: 3.51e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  14 KDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQ 93
Cdd:COG2190    4 KTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVK 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612663836  94 LDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKGET 158
Cdd:COG2190   84 LNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTKSGQVKAGDP 148
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
16-136 1.51e-62

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 188.36  E-value: 1.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   16 IAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLD 95
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 612663836   96 GEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIII 136
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 18-141 4.76e-56

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 172.09  E-value: 4.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  18 IYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGE 97
Cdd:cd00210    1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 612663836  98 GFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQ 141
Cdd:cd00210   81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 18-138 2.47e-54

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 167.42  E-value: 2.47e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   18 IYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGE 97
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 612663836   98 GFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITN 138
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PTS-II-ABC-beta TIGR01995
PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS ...
 9-156 1.43e-51

PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.


Pssm-ID: 273919 [Multi-domain]  Cd Length: 610  Bit Score: 173.31  E-value: 1.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836    9 GKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIG 88
Cdd:TIGR01995 456 AAALSKDESLYAPVAGEMLPLNEVPDEVFSSGAMGKGIAILPTEGEVVAPVDGTVTAVFPTKHAIGIRSDNGIEILIHVG 535

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612663836   89 LDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKG 156
Cdd:TIGR01995 536 IDTVELNGEGFEILVKVGDHVKAGQLLLTFDLDKIKEAGYDPTTPVVVTNTKDFLDVIPTDKETVTAG 603
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 2-165 8.36e-46

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 147.43  E-value: 8.36e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836   2 FKKLFGKGKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGL 81
Cdd:PRK09439   7 LKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  82 ELLVHIGLDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINiYDENAVIKGETKVI 161
Cdd:PRK09439  87 ELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELI-KLSGSVTAGETPVI 165


                 ....
gi 612663836 162 DVTM 165
Cdd:PRK09439 166 RVKK 169
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 18-157 1.24e-40

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 144.08  E-value: 1.24e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  18 IYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGE 97
Cdd:PRK09824 481 ICSPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDGVEVLIHVGIDTVKLDGK 560

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  98 GFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKGE 157
Cdd:PRK09824 561 FFTAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDDYTDVLPHATAQVSAGE 620
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 17-163 5.21e-39

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 139.62  E-value: 5.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612663836  17 AIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDG 96
Cdd:PRK10255 500 ELVSPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVALEG 579

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612663836  97 EGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQATSINIYDENAVIKGETKVIDV 163
Cdd:PRK10255 580 KGFKRLVEEGAQVSAGQPILEMDLDYLNANARSMISPVVCSNIDDFSGLIIKAQGHVVAGQTPLYEI 646
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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