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Conserved domains on  [gi|612662554|gb|EZS78786|]
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hypothetical protein W490_01336 [Staphylococcus aureus VET0191R]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11454411)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
171-254 2.07e-25

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 100.32  E-value: 2.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   171 DLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTP 250
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 612662554   251 KQYR 254
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
1-254 3.66e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.77  E-value: 3.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   1 MQRDYLIRVETESMPDFKRLNGLMIGFVIKGEAHIYDENNMTQCVSGDIFIINHRDLYRFQLQQDGIICYIHFQMKYLAD 80
Cdd:COG2207    9 LLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  81 KFDDVHCLYFHLTDATTTKNIHQLRNIMARLVSTHIRHNELSKLTEQQLVIQLLMHMIHYVPRTYHSNQSILnddkvnqv 160
Cdd:COG2207   89 LLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL-------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 161 cdyIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFAR 240
Cdd:COG2207  161 ---LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSR 237

                        250
                 ....*....|....
gi 612662554 241 TFKHFTHQTPKQYR 254
Cdd:COG2207  238 AFKKRFGVTPSEYR 251
XynB super family cl42385
Beta-xylosidase [Carbohydrate transport and metabolism];
524-741 9.55e-08

Beta-xylosidase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3664:

Pssm-ID: 442881  Cd Length: 490  Bit Score: 55.31  E-value: 9.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 524 PLILLNWNT-LTGDTFITNGeYFRGGIIIEQLLKLSSKVEGIGYWLNYDLHvshcrnErDYMNSIELFH------QYNG- 595
Cdd:COG3664  279 PLHITEWNTsYTPRDPYHDT-AFYAAYIAKSLKRAGDLADSMSYWTFSDIF------E-EAGPPTQPFHggfgllNTNGi 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 596 KRPVYFTALLFNKLTSNILYSDDTCIVTGTDS--NFQILLYDakhfnpyLALDNQMNMRATemIHLNINALEDGMYKIKH 673
Cdd:COG3664  351 KKPVYHAFRMLNRLGGERLAVGDDDAVATRDDdgRVAVLVWN-------YHDDDPAGPART--VELTLTGLPAGKYRLTV 421

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612662554 674 FTLDKENGALFNLWRKhhtihgM------DKDSIDYVNRMSFPKLEVYDIDVTD-TLALNIKMITNGIHLIEVKR 741
Cdd:COG3664  422 YRVDEEHGNAYAAWLE------MgspqqpTREQIAELKAAAELQTSPEVVVVADgKLTLDLTLPRNSVVLIELTP 490
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
171-254 2.07e-25

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 100.32  E-value: 2.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   171 DLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTP 250
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 612662554   251 KQYR 254
Cdd:smart00342  81 SEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 136-254 2.09e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 107.55  E-value: 2.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 136 HMIHYVPRTYHSNQSIL-------NDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTR 208
Cdd:COG4977  184 RLVVDPRRPGGQAQFSPllvplghRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLR 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 612662554 209 IEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:COG4977  264 LERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYR 309
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
1-254 3.66e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.77  E-value: 3.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   1 MQRDYLIRVETESMPDFKRLNGLMIGFVIKGEAHIYDENNMTQCVSGDIFIINHRDLYRFQLQQDGIICYIHFQMKYLAD 80
Cdd:COG2207    9 LLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  81 KFDDVHCLYFHLTDATTTKNIHQLRNIMARLVSTHIRHNELSKLTEQQLVIQLLMHMIHYVPRTYHSNQSILnddkvnqv 160
Cdd:COG2207   89 LLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL-------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 161 cdyIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFAR 240
Cdd:COG2207  161 ---LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSR 237

                        250
                 ....*....|....
gi 612662554 241 TFKHFTHQTPKQYR 254
Cdd:COG2207  238 AFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
177-254 1.33e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.19  E-value: 1.33e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612662554  177 LSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTY-TDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
92-254 1.50e-13

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 71.93  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  92 LTDATTTKNIHQLrniMARLVSTHIRHNELSKLTEQQLVIQLLMHMIHYVPRtyhSNQSILnDDKVNQVCDYIELHFHED 171
Cdd:PRK10572 127 IPDEALQPEFSDL---FGQIEQAGQSEGRYSELLAMNLLERLLLRCMEAIPE---SLHPPM-DPRVREACQYISDHLASE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 172 LSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPK 251
Cdd:PRK10572 200 FDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPS 279


                 ...
gi 612662554 252 QYR 254
Cdd:PRK10572 280 EFR 282
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 157-254 1.20e-10

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 63.93  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  157 VNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLdLTYTDETITDIALQNGFSSAA 236
Cdd:TIGR04094 287 IRAVIQYINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKIEEAKY-LLRSQIPVSEVSNELGFYDLS 365

                          90
                  ....*....|....*...
gi 612662554  237 SFARTFKHFTHQTPKQYR 254
Cdd:TIGR04094 366 HFSRTFKKHTGVSPKQYQ 383
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
524-741 9.55e-08

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 55.31  E-value: 9.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 524 PLILLNWNT-LTGDTFITNGeYFRGGIIIEQLLKLSSKVEGIGYWLNYDLHvshcrnErDYMNSIELFH------QYNG- 595
Cdd:COG3664  279 PLHITEWNTsYTPRDPYHDT-AFYAAYIAKSLKRAGDLADSMSYWTFSDIF------E-EAGPPTQPFHggfgllNTNGi 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 596 KRPVYFTALLFNKLTSNILYSDDTCIVTGTDS--NFQILLYDakhfnpyLALDNQMNMRATemIHLNINALEDGMYKIKH 673
Cdd:COG3664  351 KKPVYHAFRMLNRLGGERLAVGDDDAVATRDDdgRVAVLVWN-------YHDDDPAGPART--VELTLTGLPAGKYRLTV 421

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612662554 674 FTLDKENGALFNLWRKhhtihgM------DKDSIDYVNRMSFPKLEVYDIDVTD-TLALNIKMITNGIHLIEVKR 741
Cdd:COG3664  422 YRVDEEHGNAYAAWLE------MgspqqpTREQIAELKAAAELQTSPEVVVVADgKLTLDLTLPRNSVVLIELTP 490
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
47-254 4.47e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 49.13  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  47 GDIFIINHRDLYRFQ----LQQDGII-CYIHFQM-----KYLADKFDDVHCLYFHLTdattTKNIHQLRNIMARLVSTHI 116
Cdd:PRK13501  63 GDVFYIQAADHHSYEsvhdLVLDNIIyCPERLHLnaqwhKLLPPLGPEQNQGYWRLT----TQGMAQARPIIQQLAQESR 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 117 RHNELSKLTEQQLVIQLLMHMIHYVPRTYHSNQsILNDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESL 196
Cdd:PRK13501 139 KTDSWSIQLTEVLLLQLAIVLKRHRYRAEQAHL-LPDGEQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQT 217

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 612662554 197 GVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK13501 218 GMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYR 275
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
171-254 2.07e-25

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 100.32  E-value: 2.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   171 DLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTP 250
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 612662554   251 KQYR 254
Cdd:smart00342  81 SEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 136-254 2.09e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 107.55  E-value: 2.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 136 HMIHYVPRTYHSNQSIL-------NDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTR 208
Cdd:COG4977  184 RLVVDPRRPGGQAQFSPllvplghRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLR 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 612662554 209 IEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:COG4977  264 LERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYR 309
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
1-254 3.66e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.77  E-value: 3.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554   1 MQRDYLIRVETESMPDFKRLNGLMIGFVIKGEAHIYDENNMTQCVSGDIFIINHRDLYRFQLQQDGIICYIHFQMKYLAD 80
Cdd:COG2207    9 LLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  81 KFDDVHCLYFHLTDATTTKNIHQLRNIMARLVSTHIRHNELSKLTEQQLVIQLLMHMIHYVPRTYHSNQSILnddkvnqv 160
Cdd:COG2207   89 LLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLL-------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 161 cdyIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFAR 240
Cdd:COG2207  161 ---LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSR 237

                        250
                 ....*....|....
gi 612662554 241 TFKHFTHQTPKQYR 254
Cdd:COG2207  238 AFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
177-254 1.33e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.19  E-value: 1.33e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612662554  177 LSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTY-TDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 153-254 9.57e-21

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 94.74  E-value: 9.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 153 NDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTyTDETITDIALQNGF 232
Cdd:COG2169   82 RADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGF 160

                         90       100
                 ....*....|....*....|..
gi 612662554 233 SSAASFARTFKHFTHQTPKQYR 254
Cdd:COG2169  161 GSLSRFYEAFKKLLGMTPSAYR 182
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
92-254 1.50e-13

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 71.93  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  92 LTDATTTKNIHQLrniMARLVSTHIRHNELSKLTEQQLVIQLLMHMIHYVPRtyhSNQSILnDDKVNQVCDYIELHFHED 171
Cdd:PRK10572 127 IPDEALQPEFSDL---FGQIEQAGQSEGRYSELLAMNLLERLLLRCMEAIPE---SLHPPM-DPRVREACQYISDHLASE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 172 LSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPK 251
Cdd:PRK10572 200 FDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPS 279


                 ...
gi 612662554 252 QYR 254
Cdd:PRK10572 280 EFR 282
PRK10371 PRK10371
transcriptional regulator MelR;
109-254 3.45e-13

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 71.00  E-value: 3.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 109 ARLVSTH-IR--HNELSKLTEQ--QLVIQLLMHMIHYV------------PRTYHSNQsiLNDDK---VNQVCDYIELHF 168
Cdd:PRK10371 127 TQQLSPFeVRrwQQELNSPNEQirQLAIDEIGLMLKRFslsgwepilvnkTSRTHKNS--VSRHAqfyVSQMLGFIAENY 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 169 HEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQ 248
Cdd:PRK10371 205 DQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTFGKYVGM 284


                 ....*.
gi 612662554 249 TPKQYR 254
Cdd:PRK10371 285 SPQQYR 290
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 157-254 1.20e-10

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 63.93  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  157 VNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLdLTYTDETITDIALQNGFSSAA 236
Cdd:TIGR04094 287 IRAVIQYINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKIEEAKY-LLRSQIPVSEVSNELGFYDLS 365

                          90
                  ....*....|....*...
gi 612662554  237 SFARTFKHFTHQTPKQYR 254
Cdd:TIGR04094 366 HFSRTFKKHTGVSPKQYQ 383
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
157-254 1.21e-09

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 56.65  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 157 VNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAA 236
Cdd:PRK11511  11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90

                         90
                 ....*....|....*...
gi 612662554 237 SFARTFKHFTHQTPKQYR 254
Cdd:PRK11511  91 TLTRTFKNYFDVPPHKYR 108
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
151-254 4.49e-09

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 54.55  E-value: 4.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 151 ILNDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQN 230
Cdd:PRK10219   1 MSHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDL 80

                         90       100
                 ....*....|....*....|....
gi 612662554 231 GFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK10219  81 GYVSQQTFSRVFRRQFDRTPSDYR 104
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
153-262 6.07e-08

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 54.68  E-value: 6.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 153 NDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGF 232
Cdd:PRK13503 169 SDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGF 248

                         90       100       110
                 ....*....|....*....|....*....|
gi 612662554 233 SSAASFARTFKHFTHQTPKQYRGDRPAITE 262
Cdd:PRK13503 249 GDSNHFSTLFRREFSWSPRDIRQGRDGFLQ 278
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
524-741 9.55e-08

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 55.31  E-value: 9.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 524 PLILLNWNT-LTGDTFITNGeYFRGGIIIEQLLKLSSKVEGIGYWLNYDLHvshcrnErDYMNSIELFH------QYNG- 595
Cdd:COG3664  279 PLHITEWNTsYTPRDPYHDT-AFYAAYIAKSLKRAGDLADSMSYWTFSDIF------E-EAGPPTQPFHggfgllNTNGi 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 596 KRPVYFTALLFNKLTSNILYSDDTCIVTGTDS--NFQILLYDakhfnpyLALDNQMNMRATemIHLNINALEDGMYKIKH 673
Cdd:COG3664  351 KKPVYHAFRMLNRLGGERLAVGDDDAVATRDDdgRVAVLVWN-------YHDDDPAGPART--VELTLTGLPAGKYRLTV 421

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612662554 674 FTLDKENGALFNLWRKhhtihgM------DKDSIDYVNRMSFPKLEVYDIDVTD-TLALNIKMITNGIHLIEVKR 741
Cdd:COG3664  422 YRVDEEHGNAYAAWLE------MgspqqpTREQIAELKAAAELQTSPEVVVVADgKLTLDLTLPRNSVVLIELTP 490
ftrA PRK09393
transcriptional activator FtrA; Provisional
 159-254 1.11e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.20  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 159 QVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASF 238
Cdd:PRK09393 222 PLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESL 301

                         90
                 ....*....|....*.
gi 612662554 239 ARTFKHFTHQTPKQYR 254
Cdd:PRK09393 302 RHHFRRRAATSPAAYR 317
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
163-260 1.70e-07

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 53.47  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 163 YIELHFHEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTF 242
Cdd:PRK15121  13 WLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRAF 92

                         90       100
                 ....*....|....*....|....*.
gi 612662554 243 KHFTHQTPKQYR--------GDRPAI 260
Cdd:PRK15121  93 KKQFAQTPALYRrspewsafGIRPPI 118
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
47-254 4.47e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 49.13  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554  47 GDIFIINHRDLYRFQ----LQQDGII-CYIHFQM-----KYLADKFDDVHCLYFHLTdattTKNIHQLRNIMARLVSTHI 116
Cdd:PRK13501  63 GDVFYIQAADHHSYEsvhdLVLDNIIyCPERLHLnaqwhKLLPPLGPEQNQGYWRLT----TQGMAQARPIIQQLAQESR 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 117 RHNELSKLTEQQLVIQLLMHMIHYVPRTYHSNQsILNDDKVNQVCDYIELHFHEDLSLSELSEYVGWSESHLSKKFAESL 196
Cdd:PRK13501 139 KTDSWSIQLTEVLLLQLAIVLKRHRYRAEQAHL-LPDGEQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQT 217

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 612662554 197 GVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK13501 218 GMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYR 275
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 170-254 1.06e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 48.10  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 170 EDLSLSELSEYVGWSESHLSKKFAESlGVGFQHFlnttrIEHAKLDLTYTD-------ETITDIALQNGFSSAASFARTF 242
Cdd:PRK09685 213 EILRPEWIAGELGISVRSLYRLFAEQ-GLVVAQY-----IRNRRLDRCADDlrpaaddEKITSIAYKWGFSDSSHFSTAF 286

                         90
                 ....*....|..
gi 612662554 243 KHFTHQTPKQYR 254
Cdd:PRK09685 287 KQRFGVSPGEYR 298
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 204-254 1.21e-05

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 47.83  E-value: 1.21e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612662554 204 LNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK10296 221 INEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYR 271
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
103-254 1.74e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 47.40  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 103 QLRNIMARLVSTHIRH----NELSKLTEQQLVIQLLMHMIHYVPRTYHSNQSILNddkvnQVCDYIELHFHEDLSLSELS 178
Cdd:PRK13500 155 QARQVIGQLEHESSQHvpfaNEMAELLFGQLVMLLNRHRYTSDSLPPTSSETLLD-----KLITRLAASLKSPFALDKFC 229

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612662554 179 EYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK13500 230 DEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWR 305
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
109-254 1.86e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 47.36  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 109 ARLVSTHIRH---------NELSKLTEQQLVIQLLMHMIHYVPRTYHSNQSILnDDKVNQVCDYIELHFhedlSLSELSE 179
Cdd:PRK13502 126 ARQVINQLEHesngrdplaNEMAELLFGQLVMTLKRHRYATDDLPATSRETLL-DKLITALANSLECPF----ALDAFCQ 200

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612662554 180 YVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTYTDETITDIALQNGFSSAASFARTFKHFTHQTPKQYR 254
Cdd:PRK13502 201 QEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
155-261 8.71e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 42.09  E-value: 8.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662554 155 DKVNQVCDYIELHfhEDLSLSELSEYVGWSESHLSKKFAESLGVGFQHFLNTTRIEHAKLDLTyTDETITDIALQNGFSS 234
Cdd:PRK15435  85 DKITHACRLLEQE--TPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALA-KGESVTTSILNAGFPD 161

                         90       100
                 ....*....|....*....|....*....
gi 612662554 235 AASFARTFKHFTHQTPKQYR--GDRPAIT 261
Cdd:PRK15435 162 SSSYYRKADETLGMTAKQFRhgGENLAVR 190
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 219-254 2.65e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.98  E-value: 2.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 612662554  219 TDETITDIALQNGFSSAAsFARTFKHFTHQTPKQYR 254
Cdd:pfam00165   7 TNLTIADIADELGFSRSY-FSRLFKKYTGVTPSQYR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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