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Conserved domains on  [gi|612662024|gb|EZS78262|]
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homoserine kinase [Staphylococcus aureus VET0191R]

Protein Classification

homoserine kinase( domain architecture ID 11414705)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

CATH:  3.30.70.890|3.30.230.10
EC:  2.7.1.39
Gene Ontology:  GO:0009088|GO:0004413|GO:0005524
PubMed:  11188689|11535056
SCOP:  4001303|4000959

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 8-298 1.68e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


:

Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 340.15  E-value: 1.68e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPNLCIEMRS 87
Cdd:COG0083    6 RVPATSANLGPGFDSLGLALSLYDEVEVERSDEPGLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIEIEK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  88 DIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvsKETSVAHIDIP-DV 166
Cdd:COG0083   86 GIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDG--EPVRVVRLPVPpDL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 167 DVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMqQDGFHEPYRQHLIAEFDEVKTIAS 246
Cdd:COG0083  164 KAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAM-EDRLHEPYRAKLIPGFDEVKEAAL 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 612662024 247 QHNAYATVISGAGPTILIFSRKENSGELVRAL----NRNVVTCHSELVDINVSGVK 298
Cdd:COG0083  243 EAGALGAGISGAGPTVLALADDEEAEAVAEAMkaafAEAGIDARVYVLKIDNEGAR 298
 
Name Accession Description Interval E-value
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 8-298 1.68e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 340.15  E-value: 1.68e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPNLCIEMRS 87
Cdd:COG0083    6 RVPATSANLGPGFDSLGLALSLYDEVEVERSDEPGLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIEIEK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  88 DIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvsKETSVAHIDIP-DV 166
Cdd:COG0083   86 GIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDG--EPVRVVRLPVPpDL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 167 DVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMqQDGFHEPYRQHLIAEFDEVKTIAS 246
Cdd:COG0083  164 KAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAM-EDRLHEPYRAKLIPGFDEVKEAAL 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 612662024 247 QHNAYATVISGAGPTILIFSRKENSGELVRAL----NRNVVTCHSELVDINVSGVK 298
Cdd:COG0083  243 EAGALGAGISGAGPTVLALADDEEAEAVAEAMkaafAEAGIDARVYVLKIDNEGAR 298
PRK01212 PRK01212
homoserine kinase; Provisional
 8-298 1.33e-116

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 337.89  E-value: 1.33e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEY---IFHDDASKqLPTD-ETNFIYHVAQQVAAKYSVDlPNLCI 83
Cdd:PRK01212   7 RVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVEAEFsieVIGEGADK-LPLDpEKNLVYQAALKFLEKLGKP-PGLRI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  84 EMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvskETSVAHIDI 163
Cdd:PRK01212  85 ELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEEN---GVISVKIPV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 164 P-DVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMqQDGFHEPYRQHLIAEFDEVK 242
Cdd:PRK01212 162 FdDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 612662024 243 TIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRN---VVTCHSELVDINVSGVK 298
Cdd:PRK01212 241 QAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAflqGIEGFVHVLRLDTAGAR 299
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 8-299 2.22e-76

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 235.37  E-value: 2.22e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024    8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSG--TKW-EYIFHDDASKQLPTDET-NFIYHVAQQVAAKYSVDLPNLCI 83
Cdd:TIGR00191   4 KVPASSANLGPGFDVLGAALSLYLGLTVTDVVAqeSDDtEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGIRMPPVKV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   84 EMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvsKETSVAHIDI 163
Cdd:TIGR00191  84 TLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVED--DKLEVLKIPI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  164 -PDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELaGKLMQQDGFHEPYRQHLIAEFDEVK 242
Cdd:TIGR00191 162 fSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDL-GAIMMKDRIHQPYRESLIPNLFKIK 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612662024  243 TIASQHNAYATVISGAGPTILIFSRKE----NSGELVRALNRNVVTCHSELVDINVSGVKE 299
Cdd:TIGR00191 241 QAALEKGAYGITISGSGPTILAMADEEfaeqKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 83-143 2.95e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.64  E-value: 2.95e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612662024   83 IEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSK--HEVLQLATEIEGHPDNVAPTIYGG 143
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKlaLEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 8-298 1.68e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 340.15  E-value: 1.68e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVDLPNLCIEMRS 87
Cdd:COG0083    6 RVPATSANLGPGFDSLGLALSLYDEVEVERSDEPGLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIEIEK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  88 DIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvsKETSVAHIDIP-DV 166
Cdd:COG0083   86 GIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDG--EPVRVVRLPVPpDL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 167 DVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMqQDGFHEPYRQHLIAEFDEVKTIAS 246
Cdd:COG0083  164 KAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAM-EDRLHEPYRAKLIPGFDEVKEAAL 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 612662024 247 QHNAYATVISGAGPTILIFSRKENSGELVRAL----NRNVVTCHSELVDINVSGVK 298
Cdd:COG0083  243 EAGALGAGISGAGPTVLALADDEEAEAVAEAMkaafAEAGIDARVYVLKIDNEGAR 298
PRK01212 PRK01212
homoserine kinase; Provisional
 8-298 1.33e-116

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 337.89  E-value: 1.33e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEY---IFHDDASKqLPTD-ETNFIYHVAQQVAAKYSVDlPNLCI 83
Cdd:PRK01212   7 RVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVEAEFsieVIGEGADK-LPLDpEKNLVYQAALKFLEKLGKP-PGLRI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  84 EMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvskETSVAHIDI 163
Cdd:PRK01212  85 ELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEEN---GVISVKIPV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 164 P-DVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMqQDGFHEPYRQHLIAEFDEVK 242
Cdd:PRK01212 162 FdDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 612662024 243 TIASQHNAYATVISGAGPTILIFSRKENSGELVRALNRN---VVTCHSELVDINVSGVK 298
Cdd:PRK01212 241 QAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAflqGIEGFVHVLRLDTAGAR 299
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 8-299 2.22e-76

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 235.37  E-value: 2.22e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024    8 TIPASTANLGVGFDSIGMALDKFLHLSVKETSG--TKW-EYIFHDDASKQLPTDET-NFIYHVAQQVAAKYSVDLPNLCI 83
Cdd:TIGR00191   4 KVPASSANLGPGFDVLGAALSLYLGLTVTDVVAqeSDDtEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGIRMPPVKV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   84 EMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDvsKETSVAHIDI 163
Cdd:TIGR00191  84 TLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVED--DKLEVLKIPI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  164 -PDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELaGKLMQQDGFHEPYRQHLIAEFDEVK 242
Cdd:TIGR00191 162 fSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDL-GAIMMKDRIHQPYRESLIPNLFKIK 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612662024  243 TIASQHNAYATVISGAGPTILIFSRKE----NSGELVRALNRNVVTCHSELVDINVSGVKE 299
Cdd:TIGR00191 241 QAALEKGAYGITISGSGPTILAMADEEfaeqKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
PTZ00299 PTZ00299
homoserine kinase; Provisional
 7-262 5.36e-27

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 107.67  E-value: 5.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   7 LTIPASTANLGVGFDSIGMALDKFLHLSVKETSgtKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYS-VDLPNLCIEM 85
Cdd:PTZ00299  10 LRVPATTANIGPAYDTLGMALSIFMELTVEHAD--AFSMTVEGEGSEHISTDEDNMVVQACRLAFEEYAhKSMPPLKFIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  86 RSDIPLARGLGSSASALVgaiyiANYFGDIQLSKH--------EVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETS 157
Cdd:PTZ00299  88 HSNIPYGCGCGSSSAAAV-----AGFVAGMKLCGLtmeteneeALLQAIAKFEGHPDNAAPAIYGGIQLVYKKDNGRFLT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 158 VAHIDIPDVDVIVTIPTYELK--TEASRRALPQKLTHSEAVKSsaISNTMICALAQHNYELAGKLMQQDGFHEPYR-QHL 234
Cdd:PTZ00299 163 YRVPTPPNLSVVLFVPHNKMKanTHVTRNLIPTSVSLEDAVFN--ISRTSILVLALSTGDLRMLKSCSDKLHEQQRsDAL 240

                        250       260
                 ....*....|....*....|....*...
gi 612662024 235 IAEFDEVKTIASQHNAYATVISGAGPTI 262
Cdd:PTZ00299 241 FPHFRPCVKAAREAGAHYAFLSGAGPSV 268
PLN02451 PLN02451
homoserine kinase
 10-275 4.80e-22

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 94.86  E-value: 4.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  10 PASTANLGVGFDSIGMA-----------LDKFLH---LSVKETSGTkweyifhddaSKQLPTDETNFIYHVAQQVAAKY- 74
Cdd:PLN02451  59 PATVANLGPGFDFLGCAvdglgdfvtarVDPGVRpgeVSISEITGD----------TGRLSKDPLRNCAGIAAIATMKLl 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  75 ---SVdlpNLCIEMRSDIPLARGLGSSA-SALVGAIYIANYFGDiQLSKHEVLQLATEIEG-----HPDNVAPTIYGG-- 143
Cdd:PLN02451 129 girSV---GLSLSLHKGLPLGSGLGSSAaSAAAAAVAVNELFGS-PLGKDDLVLAGLESEAkvsgyHADNIAPALMGGfv 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 144 LIAGYyndvskeTSVAHIDIP-----DVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAG 218
Cdd:PLN02451 205 LIRSY-------EPLHLIPLRfpsakDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLG 277

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 612662024 219 KLMQQDGFHEPYRQHLIAEFDEVKTIASQHNAYATVISGAGPTILIFSRKENSGELV 275
Cdd:PLN02451 278 EALSSDKIVEPTRAPLIPGMEAVKKAALEAGAYGCTISGAGPTAVAVIDDEEKGEEV 334
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 22-259 4.00e-20

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 87.98  E-value: 4.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  22 SIGMALDKFLHLSVKETSGTKWEyIFHDDASKQLPTDETN-----FIYHVAQQVAAKYSVDLPNLCIEMRSDIPLARGLG 96
Cdd:COG1577   19 AIAVAVDRRATVTVEPSDDDKLR-IESPDLGGTLDLDPLAdaalrYIKAAIEAALEYLGLPLKGFDIEIDSEIPRKRGLG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  97 SSASALVGAI-YIANYFGdIQLSKHEVLQLA--TEIEGHP-----DNVApTIYGGLIAgyyndVSKETSVAHIDIP-DVD 167
Cdd:COG1577   98 SSAAVAVAVIrALAAFYG-VELSKEELFKLAleAEKIVHGnpsglDTAA-STYGGPIY-----YQRGDRAEPLELPkNLP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 168 VIV---TIP--TYEL--KTEASRRALPQKLTHSEAvKSSAISNTMICALAQHNYELAGKLMQQdgfhepYRQHLIA---- 236
Cdd:COG1577  171 LVVgdtGVPasTKELvaKVRKLKERNPELYEAFLE-EIGDLVEEAIEALEEGDLEALGELMNE------NHGLLRAlgvs 243

                        250       260
                 ....*....|....*....|....*
gi 612662024 237 --EFDEVKTIASQHNAYATVISGAG 259
Cdd:COG1577  244 tpELDRLVEAARKAGALGAKLTGAG 268
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 19-259 2.14e-12

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 65.78  E-value: 2.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   19 GFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVAAKYSVD-LPNLCIEMRSDIPLARGLGS 97
Cdd:TIGR00549  16 GEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLSRFSELnPPPLEITIESEIPPGRGLGS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024   98 SASALVGAIYIANYFGDIQLSKHEVLQLATEIE----GHPDNVAPTI--YGGLIagYYNDVSKETSVahIDIPDVDVIVT 171
Cdd:TIGR00549  96 SAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPSGIDTATstSGGPV--YFEKGEGEFTK--LISLDGYFVIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  172 IPTYELKT-EASRRALPQKLTHSEAVKSS-----AISNTMICALAQHNYELAGKLMQQDgfhepyrQHLIAEF------- 238
Cdd:TIGR00549 172 DTGVSGSTkEAVARVRQLLERFPELIDSImdaigELTLEAKAALQDGDVESLGELMNIN-------QGLLKALgvshpkl 244

                         250       260
                  ....*....|....*....|.
gi 612662024  239 DEVKTIASQHNAYATVISGAG 259
Cdd:TIGR00549 245 DQLVEIARKAGALGAKLTGAG 265
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 83-143 2.95e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.64  E-value: 2.95e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612662024   83 IEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSK--HEVLQLATEIEGHPDNVAPTIYGG 143
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKlaLEAEELAGGGRGGGMDVAASLYGG 64
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 67-292 1.93e-11

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 63.33  E-value: 1.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  67 AQQVAAKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIY-IANYFGdIQLSKHEVLQLATEIEghP-DnvaPTIYGGL 144
Cdd:COG4542   57 AELTLEHLGLPPLGGRIELRSDIPVGKGMASSTADIAATARaVARALG-KELSPEELARLAVAIE--PtD---STMFPGL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 145 IAgyyndvsketsVAHID---------IPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYE 215
Cdd:COG4542  131 VL-----------FDHREgrvleplgpLPPLDILGLDSGGTVDTLAFNRRDLAELNRAEEPEIERALALLREALRTGDLA 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024 216 LAGKLMQQDGFHEpyrQHLI--AEFDEVKTIASQHNAYATVI--SG--AGptiLIFSRKENSGE-LVRALNRNVVTCHSE 288
Cdd:COG4542  200 LLGEAATLSARAN---QRILpkPELEELLALAEELGALGVNVahSGtvLG---LLFDPGDHDVEkLAEALRRRLLRLGYP 273


                 ....
gi 612662024 289 LVDI 292
Cdd:COG4542  274 RIGL 277
PRK03926 PRK03926
mevalonate kinase; Provisional
 76-130 1.51e-03

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 39.65  E-value: 1.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 612662024  76 VDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIE 130
Cdd:PRK03926  71 ADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVE 125
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 208-283 3.98e-03

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 35.91  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612662024  208 ALAQHNYELAGKLMQQDGF-HEPYRQH--LIAEFDEVKTIASQHNaYATVISGA--GPTIL-IFSRKENSGELVRALNRN 281
Cdd:pfam08544   4 ALLRGDLEELGKLLTESAEsLEPLLVVgiLPPELDELLEALLELG-LGAKLSGSggGPTVFaLFKDEDDAEEVARALREA 82


                  ..
gi 612662024  282 VV 283
Cdd:pfam08544  83 GK 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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