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Conserved domains on  [gi|612661771|gb|EZS78012|]
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hypothetical protein W490_01618 [Staphylococcus aureus VET0191R]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-282 2.86e-69

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 216.33  E-value: 2.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   1 MMTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYLPEDI 80
Cdd:COG1737    3 SAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  81 ATNPHLELIE-NESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLN 159
Cdd:COG1737   83 SSYERLRRLSpDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 160 VRLL-HETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYgRTDENEMR 238
Cdd:COG1737  163 VVLLdGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYV-PSEEPTLR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 612661771 239 MAATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKVALDNYR 282
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-282 2.86e-69

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 216.33  E-value: 2.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   1 MMTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYLPEDI 80
Cdd:COG1737    3 SAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  81 ATNPHLELIE-NESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLN 159
Cdd:COG1737   83 SSYERLRRLSpDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 160 VRLL-HETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYgRTDENEMR 238
Cdd:COG1737  163 VVLLdGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYV-PSEEPTLR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 612661771 239 MAATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKVALDNYR 282
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-257 1.77e-31

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 114.25  E-value: 1.77e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 119 AQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIA 198
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 612661771 199 QVATHYSIPIITISSTANNPVAQIADYALIYGrTDENEMRMAATTSLFAQLFTVDILYY 257
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVS-SEEGDFRSSAFSSRIAQLALIDALFL 138
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
6-263 7.23e-30

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 114.02  E-value: 7.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   6 LYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAI------SRYLPED 79
Cdd:PRK15482   4 LTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALigeysaSREKTNA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  80 IATNPHLELIENESVEtlknkMIARATNTMRFVA----TNIMD-AQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLS 154
Cdd:PRK15482  84 TALHLHSSITSDDSLE-----VIARKLNREKELAleqtCALFDyARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLM 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 155 RIGLNVRLLHETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYAL--IYGrt 232
Cdd:PRK15482 159 KIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLdtVSG-- 236

                        250       260       270
                 ....*....|....*....|....*....|.
gi 612661771 233 dENEMRMAATTSLFAQLFTVDILYYRFVALN 263
Cdd:PRK15482 237 -ETEWRSSSMSTRTAQNSVTDLLFVGLVQLN 266
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 3-76 1.84e-19

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 80.45  E-value: 1.84e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612661771    3 TNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYL 76
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGEL 74
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-282 2.86e-69

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 216.33  E-value: 2.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   1 MMTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYLPEDI 80
Cdd:COG1737    3 SAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  81 ATNPHLELIE-NESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLN 159
Cdd:COG1737   83 SSYERLRRLSpDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 160 VRLL-HETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYgRTDENEMR 238
Cdd:COG1737  163 VVLLdGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYV-PSEEPTLR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 612661771 239 MAATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKVALDNYR 282
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-257 1.77e-31

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 114.25  E-value: 1.77e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 119 AQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIA 198
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 612661771 199 QVATHYSIPIITISSTANNPVAQIADYALIYGrTDENEMRMAATTSLFAQLFTVDILYY 257
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVS-SEEGDFRSSAFSSRIAQLALIDALFL 138
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
6-263 7.23e-30

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 114.02  E-value: 7.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   6 LYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAI------SRYLPED 79
Cdd:PRK15482   4 LTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALigeysaSREKTNA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  80 IATNPHLELIENESVEtlknkMIARATNTMRFVA----TNIMD-AQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLS 154
Cdd:PRK15482  84 TALHLHSSITSDDSLE-----VIARKLNREKELAleqtCALFDyARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLM 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 155 RIGLNVRLLHETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYAL--IYGrt 232
Cdd:PRK15482 159 KIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLdtVSG-- 236

                        250       260       270
                 ....*....|....*....|....*....|.
gi 612661771 233 dENEMRMAATTSLFAQLFTVDILYYRFVALN 263
Cdd:PRK15482 237 -ETEWRSSSMSTRTAQNSVTDLLFVGLVQLN 266
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
8-256 2.23e-29

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 112.55  E-value: 2.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   8 RIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYL---PEDIATNP 84
Cdd:PRK11557   2 RIRQRYPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALasqPEPPSVPV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  85 HLELIENESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLH 164
Cdd:PRK11557  82 HNQIRGDDPLRLVGEKLIKENTAAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAER 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 165 ETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALiYGRTDENEMRMAATTS 244
Cdd:PRK11557 162 DMHALLATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCL-YTIAEEQATRSAAISS 240

                        250
                 ....*....|..
gi 612661771 245 LFAQLFTVDILY 256
Cdd:PRK11557 241 THAQGMLTDLLF 252
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
8-283 7.91e-21

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 89.82  E-value: 7.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   8 RIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYLPEDIAtNPHLE 87
Cdd:PRK11337  18 YIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDYFSQSEQ-VLHSE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  88 LIENESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETH 167
Cdd:PRK11337  97 LSFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 168 LLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEM-RMAAttSLF 246
Cdd:PRK11337 177 IMLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQGSPLLgENAA--ARI 254

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 612661771 247 AQLFTVDILYYRFVALNYHAILDCITQSKVALDNYRK 283
Cdd:PRK11337 255 AQLNILDAFFVSVAQLNIEQAEINLQKTGAAVDFFRP 291
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 4-255 1.27e-20

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 89.28  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   4 NILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIaisrYLPEDIAT- 82
Cdd:PRK11302   2 NMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKL----HLAQSLANg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  83 ----NPHLEliENESVETLKNKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRigL 158
Cdd:PRK11302  78 tpyvNRNVE--EDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFR--F 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 159 NVRLLHETHLLV---STFATHDDrDCMIFVTNQGSHSELQSIAQVATHYSIPIITISStANNPVAQIADYALIYGRTDEN 235
Cdd:PRK11302 154 NVPVVYFDDIVMqrmSCMNSSDG-DVVVLISHTGRTKSLVELAQLARENGATVIAITS-AGSPLAREATLALTLDVPEDT 231

                        250       260
                 ....*....|....*....|
gi 612661771 236 EMRMaATTSLFAQLFTVDIL 255
Cdd:PRK11302 232 DIYM-PMVSRIAQLTVIDVL 250
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 3-76 1.84e-19

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 80.45  E-value: 1.84e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612661771    3 TNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYL 76
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGEL 74
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
5-255 3.84e-19

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 87.28  E-value: 3.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771   5 ILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKMTHQGFQELKIAISRYLPEDIAtnp 84
Cdd:PRK14101 343 VFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIP--- 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  85 hlelienesvetLKNKMIARATNTMRFVATnIMDAQIDAI---------------CDVLKNARTIFLFGFGASSLTIGDL 149
Cdd:PRK14101 420 ------------MSHSQVHLGDTATDFGAK-VLDNTVSAIlqlrehlnfehveqaIDILNNARRIEFYGLGNSNIVAQDA 486

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771 150 FQKLSRIGLNVRLLHETHLLVSTFATHDDRDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTaNNPVAQIADYALiy 229
Cdd:PRK14101 487 HYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSS-NTPLAKRATVAL-- 563

                        250       260
                 ....*....|....*....|....*...
gi 612661771 230 gRTDENEMRMA--ATTSLFAQLFTVDIL 255
Cdd:PRK14101 564 -ETDHIEMRESqlSMISRILHLVMIDIL 590
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 128-256 1.23e-09

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 55.38  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  128 LKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATH-DDRDCMIFVTNQGSHSELQSIAQVATHYSI 206
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGVLALvDEDDLVIAISYSGETKDLLAAAELAKARGA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 612661771  207 PIITISSTANNPVAQIADYAlIYGRTDENEMrMAATTSLFAQLFTVDILY 256
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHV-LYINAGPETG-VASTKSITAQLAALDALA 129
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 99-228 4.55e-06

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 46.03  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612661771  99 NKMIARATNTMRFVATNIMDAQIDAICDVLKNARTIFLFGFGASSLtIGDLF-QKLSRIGLNVRLLHEThllvSTFATHD 177
Cdd:cd05005    1 MEYLSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGL-VAKAFaMRLMHLGLNVYVVGET----TTPAIGP 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 612661771 178 DrDCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALI 228
Cdd:cd05005   76 G-DLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVV 125
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 180-255 4.91e-04

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 41.12  E-value: 4.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612661771 180 DCMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENE-MRMAATTSLFAQLFTVDIL 255
Cdd:COG0794   93 DVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPVEREACpLNLAPTTSTTATLALGDAL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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