|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10522 |
PRK10522 |
multidrug transporter membrane component/ATP-binding component; Provisional |
1-550 |
0e+00 |
|
multidrug transporter membrane component/ATP-binding component; Provisional
Pssm-ID: 236707 [Multi-domain] Cd Length: 547 Bit Score: 922.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 1 MELLRVVYRQYRWPFLAVMALTMASAGLGIGIIAFINQYLMDVSGNPLAVLPMFLALLALLIAVTLGSQLALTTLGHYFV 80
Cdd:PRK10522 1 MELLRLVWRQYRWPFISVMALSLASAALGIGLIAFINQRLIETADTSLLVLPEFLGLLLLLMAVTLGSQLALTTLGHHFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 81 YRLRGQLVKRILDTEIERLEQLGSASLLASLSSDIRNITIAFVRLPELVQGVILTLGAAAYLGWLSPKMLAVTAVWVAVT 160
Cdd:PRK10522 81 YRLRSEFIKRILDTHVERIEQLGSASLLASLTSDVRNITIAFVRLPELVQGIILTLGSAAYLAWLSPKMLLVTAIWMAVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 161 VVGSGCLVSRVYRHMASLRESEERLYHRYESVIDGRKELTLNRKRAQALYEQAYQPDAQAYRYHIIRADTFHLSALNWSN 240
Cdd:PRK10522 161 IWGGFVLVARVYKHMATLRETEDKLYNDYQTVLEGRKELTLNRERAEYVFENEYEPDAQEYRHHIIRADTFHLSAVNWSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 241 IMMLGAIGLVFFMANSLGWADSTVAATYSLTLLFLRTPLLQAVGAFPTLVGAEVAFNKLKALRLAEYQSGFPA-AVGRSW 319
Cdd:PRK10522 241 IMMLGAIGLVFYMANSLGWADTNVAATYSLTLLFLRTPLLSAVGALPTLLSAQVAFNKLNKLALAPYKAEFPRpQAFPDW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 QTLELRDVVFHYADaeqqPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYR 399
Cdd:PRK10522 321 QTLELRNVTFAYQD----NGFSVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDGKPVTAEQPEDYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDFHQFDRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEW 479
Cdd:PRK10522 397 KLFSAVFTDFHLFDQLLGPEGKPANPALVEKWLERLKMAHKLELEDGRISNLKLSKGQKKRLALLLALAEERDILLLDEW 476
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 480 AADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSEREHASRDSVSRIG 550
Cdd:PRK10522 477 AADQDPHFRREFYQVLLPLLQEMGKTIFAISHDDHYFIHADRLLEMRNGQLSELTGEERDAASRDAVARTA 547
|
|
| PvdE |
COG4615 |
ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion ... |
1-542 |
0e+00 |
|
ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion transport and metabolism];
Pssm-ID: 443659 [Multi-domain] Cd Length: 547 Bit Score: 714.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 1 MELLRVVYRQYRWPFLAVMALTMASAGLGIGIIAFINQYLMDVSGNPLAVLPMFLALLALLIAVTLGSQLALTTLGHYFV 80
Cdd:COG4615 1 MNLLRLLLRESRWLLLLALLLGLLSGLANAGLIALINQALNATGAALARLLLLFAGLLVLLLLSRLASQLLLTRLGQHAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 81 YRLRGQLVKRILDTEIERLEQLGSASLLASLSSDIRNITIAFVRLPELVQGVILTLGAAAYLGWLSPKMLAVTAVWVAVT 160
Cdd:COG4615 81 ARLRLRLSRRILAAPLERLERIGAARLLAALTEDVRTISQAFVRLPELLQSVALVLGCLAYLAWLSPPLFLLTLVLLGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 161 VVGSGCLVSRVYRHMASLRESEERLYHRYESVIDGRKELTLNRKRAQALYEQAYQPDAQAYRYHIIRADTFHLSALNWSN 240
Cdd:COG4615 161 VAGYRLLVRRARRHLRRAREAEDRLFKHFRALLEGFKELKLNRRRRRAFFDEDLQPTAERYRDLRIRADTIFALANNWGN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 241 IMMLGAIGLVFFMANSLGWADSTVAATYSLTLLFLRTPLLQAVGAFPTLVGAEVAFNKLKALRLAEYQ------SGFPAA 314
Cdd:COG4615 241 LLFFALIGLILFLLPALGWADPAVLSGFVLVLLFLRGPLSQLVGALPTLSRANVALRKIEELELALAAaepaaaDAAAPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 315 VGRSWQTLELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD 394
Cdd:COG4615 321 APADFQTLELRGVTYRYPGEDGDEGFTLGPIDLTIRRGELVFIVGGNGSGKSTLAKLLTGLYRPESGEILLDGQPVTADN 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 395 MPDYRRLFSAIFTDFHQFDRLQGPEgGEPDTALVAHWLERLNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDIL 474
Cdd:COG4615 401 REAYRQLFSAVFSDFHLFDRLLGLD-GEADPARARELLERLELDHKVSVEDGRFSTTDLSQGQRKRLALLVALLEDRPIL 479
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 475 LLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSEREHAS 542
Cdd:COG4615 480 VFDEWAADQDPEFRRVFYTELLPELKARGKTVIAISHDDRYFDLADRVLKMDYGKLVELTGPAALAAS 547
|
|
| cyc_pep_trnsptr |
TIGR01194 |
cyclic peptide transporter; This model describes cyclic peptide transporter in bacteria. ... |
2-528 |
2.39e-103 |
|
cyclic peptide transporter; This model describes cyclic peptide transporter in bacteria. Bacteria have elaborate pathways for the production of toxins and secondary metabolites. Many such compounds, including syringomycin and pyoverdine are synthesized on non-ribosomal templates consisting of a multienzyme complex. On several occasions the proteins of the complex and transporter protein are present on the same operon. Often times these compounds cross the biological membrane by specific transporters. Syringomycin is an amphipathic, cylclic lipodepsipeptide when inserted into host causes formation of channels, permeable to variety of cations. On the other hand, pyoverdine is a cyclic octa-peptidyl dihydroxyquinoline, which is efficient in sequestering iron for uptake. [Transport and binding proteins, Amino acids, peptides and amines, Transport and binding proteins, Other]
Pssm-ID: 130262 [Multi-domain] Cd Length: 555 Bit Score: 321.91 E-value: 2.39e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 2 ELLRVVYRQYRWPFLAVMALTMASAGLGIGIIAFINQYLMDVSGNPLAVLPMFLALLALLIAVTLGSQLALTTLGHYFVY 81
Cdd:TIGR01194 7 EILALLRSPFPAITAFSIALGLAGGLAIIALLASINNAIHEENFLGQGSLFSFGGLCLLALLFRIGADIFPAYAGMHIIA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 82 RLRGQLVKRILDTEIERLEQLGSASLLASLSSDIRNITIAFVRLPELVQGVILTLGAAAYLGWLSPKMLAVTAVWVAVTV 161
Cdd:TIGR01194 87 NLRIALCEKILGAPIEEIDRRGAHNLIPLLTHDIDQINAFLFIFPPIAIALAIFFFCIAYLAYLSVPMFAITISAIIIGT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 162 VGSGCLVSRVYRHMASLRESEERLYHRYESVIDGRKELTLNRKRAQALYEQAYQPDAQAYR-YHIIRADTFHLsALNWSN 240
Cdd:TIGR01194 167 AAQLLAFMGGFKFFHAARDEEDAFNEHTHAIAFGAKELKIHGIRRLSFAHGAIQESANNIAdLHIIEILIFIA-AENFGQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 241 IMMLGAIGLVFFMANSLGWADSTVAATYSLTLLFLRTPLLQAVGAFPTLVGAEVAFNKLKAL-----------RLAEYQS 309
Cdd:TIGR01194 246 LLFFLLIGCALFAAAMFASIDAAAISAFVLALLYIKGPLEMLVSALPILAQAQIACQRLADFgerfnepepelELSDADN 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 310 GFPAAVGRSWQTLELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA 389
Cdd:TIGR01194 326 VLLLAHDKSVDSIELKDVHMNPKAPEGSEGFALGPIDLRIAQGDIVFIVGENGCGKSTLAKLFCGLYIPQEGEILLDGAA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 390 QTAADMPDYRRLFSAIFTDFHQFDRLQGPEGGE-PDTALVAHWLERLNMKSKLQF-DGARVTNPQLSQGQRKRLALLLAV 467
Cdd:TIGR01194 406 VSADSRDDYRDLFSAIFADFHLFDDLIGPDEGEhASLDNAQQYLQRLEIADKVKIeDGGFSTTTALSTGQQKRLALICAW 485
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 468 AEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:TIGR01194 486 LEDRPILLFDEWAADQDPAFKRFFYEELLPDLKRQGKTIIIISHDDQYFELADQIIKLAAG 546
|
|
| ABCC_MRP_Like |
cd03228 |
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ... |
322-529 |
3.27e-38 |
|
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 138.28 E-value: 3.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03228 1 IEFKNVSFSYPGRPKP---VLKDVSLTIKPGEKVAIVGPSGSGKSTLLKLLLRLYDPTSGEILIDGVDLRDLDLESLRKN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDrlqgpeggepDTalVAHwlerlNMksklqfdgarvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03228 78 IAYVPQDPFLFS----------GT--IRE-----NI---------------LSGGQRQRIAIARALLRDPPILILDEATS 125
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 482 DQDPQFRRIFYRellpALRAL--GKTVFAISHDDHYFEHADRLLEMRSGH 529
Cdd:cd03228 126 ALDPETEALILE----ALRALakGKTVIVIAHRLSTIRDADRIIVLDDGR 171
|
|
| ABC_cobalt_CbiO_domain1 |
cd03225 |
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
323-529 |
7.70e-37 |
|
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.
Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 135.67 E-value: 7.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:cd03225 1 ELKNLSFSYPDGARP---ALDDISLTIKKGEFVLIVGPNGSGKSTLLRLLNGLLGPTSGEVLVDGKDLTKLSLKELRRKV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFTD-FHQF-------DRLQGPE--GGEPDTAL--VAHWLERLNMKSKLQfdgarvTNP-QLSQGQRKRLALLLAVAE 469
Cdd:cd03225 78 GLVFQNpDDQFfgptveeEVAFGLEnlGLPEEEIEerVEEALELVGLEGLRD------RSPfTLSGGQKQRVAIAGVLAM 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFyRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGH 529
Cdd:cd03225 152 DPDILLLDEPTAGLDPAGRREL-LELLKKLKAEGKTIIIVTHDlDLLLELADRVIVLEDGK 211
|
|
| EcfA2 |
COG1122 |
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ... |
322-530 |
3.26e-35 |
|
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 132.07 E-value: 3.26e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:COG1122 1 IELENLSFSYPGGTP----ALDDVSLSIEKGEFVAIIGPNGSGKSTLLRLLNGLLKPTSGEVLVDGKDITKKNLRELRRK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTD-FHQF-------DRLQGPE--GGEPDTAL--VAHWLERLNMKSKLQfdgaRVTNpQLSQGQRKRLALLLAVAE 469
Cdd:COG1122 77 VGLVFQNpDDQLfaptveeDVAFGPEnlGLPREEIRerVEEALELVGLEHLAD----RPPH-ELSGGQKQRVAIAGVLAM 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG1122 152 EPEVLVLDEPTAGLDPRGRRELL-ELLKRLNKEGKTVIIVTHDlDLVAELADRVIVLDDGRI 212
|
|
| MdlB |
COG1132 |
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
8-532 |
4.22e-33 |
|
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];
Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 133.37 E-value: 4.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 8 YRQYRWPFLAVMALTMASAGLGIgIIAFINQYLMD--VSGNPLAVLPMFLALLALLIAV----TLGSQLALTTLGHYFVY 81
Cdd:COG1132 16 LRPYRGLLILALLLLLLSALLEL-LLPLLLGRIIDalLAGGDLSALLLLLLLLLGLALLrallSYLQRYLLARLAQRVVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 82 RLRGQLVKRILDTEIERLEQLGSASLLASLSSDIRNITIAFVR-LPELVQGVILTLGAAAYLGWLSPKMLAVTAVWVAVT 160
Cdd:COG1132 95 DLRRDLFEHLLRLPLSFFDRRRTGDLLSRLTNDVDAVEQFLAHgLPQLVRSVVTLIGALVVLFVIDWRLALIVLLVLPLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 161 VVGSGCLVSRVYRHMASLRESEERLYHRYESVIDGRKEL-TLNR-KRAQALYEQAyqpdAQAYRYHIIRAdtFHLSALNW 238
Cdd:COG1132 175 LLVLRLFGRRLRKLFRRVQEALAELNGRLQESLSGIRVVkAFGReERELERFREA----NEELRRANLRA--ARLSALFF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 239 SNIMMLGAIGLV--------FFMANSLGWADSTVAATYSLTLLFlrtPLLQAVGAFPTLVGAEVAFNKLKAL-----RLA 305
Cdd:COG1132 249 PLMELLGNLGLAlvllvgglLVLSGSLTVGDLVAFILYLLRLFG---PLRQLANVLNQLQRALASAERIFELldeppEIP 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 306 EYQSGFPAAVGRswQTLELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVL 385
Cdd:COG1132 326 DPPGAVPLPPVR--GEIEFENVSFSYPGDRP----VLKDISLTIPPGETVALVGPSGSGKSTLVNLLLRFYDPTSGRILI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 386 DGVAQTAADMPDYRRLFSAIFTDFHQFD-------RLqgpegGEPD-----------TALVAHWLERLnmksKLQFD--- 444
Cdd:COG1132 400 DGVDIRDLTLESLRRQIGVVPQDTFLFSgtireniRY-----GRPDatdeeveeaakAAQAHEFIEAL----PDGYDtvv 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 445 GARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQF-RRIFYrellpALRAL--GKTVFAISHDDHYFEHADR 521
Cdd:COG1132 471 GERGVN--LSGGQRQRIAIARALLKDPPILILDEATSALDTETeALIQE-----ALERLmkGRTTIVIAHRLSTIRNADR 543
|
570
....*....|.
gi 612265813 522 LLEMRSGHLRE 532
Cdd:COG1132 544 ILVLDDGRIVE 554
|
|
| FetA |
COG4619 |
ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism]; |
322-530 |
5.79e-33 |
|
ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];
Pssm-ID: 443661 [Multi-domain] Cd Length: 209 Bit Score: 124.93 E-value: 5.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFhyaDAEQQPGFtvGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:COG4619 1 LELEGLSF---RVGGKPIL--SPVSLTLEAGECVAITGPSGSGKSTLLRALADLDPPTSGEIYLDGKPLSAMPPPEWRRQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQF-----DRLQGP---EGGEPDTALVAHWLERLNM-KSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRD 472
Cdd:COG4619 76 VAYVPQEPALWggtvrDNLPFPfqlRERKFDRERALELLERLGLpPDILDKPVER-----LSGGERQRLALIRALLLQPD 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 473 ILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHL 530
Cdd:COG4619 151 VLLLDEPTSALDPENTRRVEELLREYLAEEGRAVLWVSHDPEQIERvADRVLTLEAGRL 209
|
|
| ABC_ATPase |
cd00267 |
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
323-529 |
4.20e-32 |
|
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 120.81 E-value: 4.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADaeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:cd00267 1 EIENLSFRYGG-----RTALDNVSLTLKAGEIVALVGPNGSGKSTLLRAIAGLLKPTSGEILIDGKDIAKLPLEELRRRI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFtdfhqfdrlqgpeggepdtalvahwlerlnmksklqfdgarvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAAD 482
Cdd:cd00267 76 GYVP---------------------------------------------QLSGGQRQRVALARALLLNPDLLLLDEPTSG 110
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 612265813 483 QDPQFRRIFyRELLPALRALGKTVFAISHDDHYFEHA-DRLLEMRSGH 529
Cdd:cd00267 111 LDPASRERL-LELLRELAEEGRTVIIVTHDPELAELAaDRVIVLKDGK 157
|
|
| ABC_tran |
pfam00005 |
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
344-481 |
3.57e-31 |
|
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.
Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 118.13 E-value: 3.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 344 PLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFDRLQGPE---- 419
Cdd:pfam00005 3 NVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKSLRKEIGYVFQDPQLFPRLTVREnlrl 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 420 -------GGEPDTALVAHWLERLNMKSKLQfDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:pfam00005 83 glllkglSKREKDARAEEALEKLGLGDLAD-RPVGERPGTLSGGQRQRVAIARALLTKPKLLLLDEPTA 150
|
|
| ABC_DR_subfamily_A |
cd03230 |
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ... |
322-530 |
1.20e-28 |
|
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 111.72 E-value: 1.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaQTAADMPDYRRL 401
Cdd:cd03230 1 IEVRNLSKRYGK-----KTALDDISLTVEKGEIYGLLGPNGAGKTTLIKIILGLLKPDSGEIKVLGK-DIKKEPEEVKRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQGPEggepdtalvahwlerlNMKsklqfdgarvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03230 75 IGYLPEEPSLYENLTVRE----------------NLK--------------LSGGMKQRLALAQALLHDPELLILDEPTS 124
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 482 DQDPQFRRIFyRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03230 125 GLDPESRREF-WELLRELKKEGKTILLSSHIlEEAERLCDRVAILNNGRI 173
|
|
| CydC |
COG4987 |
ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ... |
123-532 |
2.89e-28 |
|
ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444011 [Multi-domain] Cd Length: 569 Bit Score: 118.72 E-value: 2.89e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 123 VRLPELVqGVILTLGAAAYLGWLSPKMLAVTAVWVAVTVVGSGCLVSRVYRHM-ASLRESEERLYHRYESVIDGRKELTL 201
Cdd:COG4987 132 VLLPLLV-ALLVILAAVAFLAFFSPALALVLALGLLLAGLLLPLLAARLGRRAgRRLAAARAALRARLTDLLQGAAELAA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 202 N--RKRAQALYEQAYQpDAQAYRYHIIRADTFHLSALNWsnIMMLGAIGLVFFMANslGWADSTVAATYSLTLLFLRTPL 279
Cdd:COG4987 211 YgaLDRALARLDAAEA-RLAAAQRRLARLSALAQALLQL--AAGLAVVAVLWLAAP--LVAAGALSGPLLALLVLAALAL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 280 LQAVGAFPT----LVGAEVAFNKLKALRLAEYQSGFPAAVGRSWQ--TLELRDVVFHYADAEQQpgfTVGPLNLTLRRGE 353
Cdd:COG4987 286 FEALAPLPAaaqhLGRVRAAARRLNELLDAPPAVTEPAEPAPAPGgpSLELEDVSFRYPGAGRP---VLDGLSLTLPPGE 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 354 LVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFD-------RLQGPEGGepDTA 426
Cdd:COG4987 363 RVAIVGPSGSGKSTLLALLLRFLDPQSGSITLGGVDLRDLDEDDLRRRIAVVPQRPHLFDttlrenlRLARPDAT--DEE 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 427 LVA--------HWLERLN--MKSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELL 496
Cdd:COG4987 441 LWAalervglgDWLAALPdgLDTWLGEGGRR-----LSGGERRRLALARALLRDAPILLLDEPTEGLDAATEQALLADLL 515
|
410 420 430
....*....|....*....|....*....|....*.
gi 612265813 497 PALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:COG4987 516 EALA--GRTVLLITHRLAGLERMDRILVLEDGRIVE 549
|
|
| SunT |
COG2274 |
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
205-532 |
2.16e-27 |
|
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];
Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 116.86 E-value: 2.16e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 205 RAQALYEQAYQpdaqayRYHIIRADTFHLSAL--NWSN-IMMLGAIGLVFFMAN-------SLGwadsTVAATYSLTLLF 274
Cdd:COG2274 355 RFRRRWENLLA------KYLNARFKLRRLSNLlsTLSGlLQQLATVALLWLGAYlvidgqlTLG----QLIAFNILSGRF 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 275 LrTPLLQAVGAFPTLVGAEVAFNKLK---ALRLAEYQSGFPAAVGRSWQTLELRDVVFHYADAEQqpgFTVGPLNLTLRR 351
Cdd:COG2274 425 L-APVAQLIGLLQRFQDAKIALERLDdilDLPPEREEGRSKLSLPRLKGDIELENVSFRYPGDSP---PVLDNISLTIKP 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 352 GELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFD-------RLQGPeggEPD 424
Cdd:COG2274 501 GERVAIVGRSGSGKSTLLKLLLGLYEPTSGRILIDGIDLRQIDPASLRRQIGVVLQDVFLFSgtireniTLGDP---DAT 577
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 425 TALVAHWLERLN-----MKSKLQFD---GARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELL 496
Cdd:COG2274 578 DEEIIEAARLAGlhdfiEALPMGYDtvvGEGGSN--LSGGQRQRLAIARALLRNPRILILDEATSALDAETEAIILENLR 655
|
330 340 350
....*....|....*....|....*....|....*.
gi 612265813 497 PALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:COG2274 656 RLLK--GRTVIIIAHRLSTIRLADRIIVLDKGRIVE 689
|
|
| NatA |
COG4555 |
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ... |
322-533 |
2.27e-26 |
|
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 107.64 E-value: 2.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeqQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADmPDYRRL 401
Cdd:COG4555 2 IEVENLSKKY-----GKVPALKDVSFTAKDGEITGLLGPNGAGKTTLLRMLAGLLKPDSGSILIDGEDVRKEP-REARRQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQG-----------PEGGEPDTALVAHWLERLNMKSKLQFdgaRVTNpqLSQGQRKRLALLLAVAEQ 470
Cdd:COG4555 76 IGVLPDERGLYDRLTVreniryfaelyGLFDEELKKRIEELIELLGLEEFLDR---RVGE--LSTGMKKKVALARALVHD 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 471 RDILLLDEWAADQDPQFRRIFYRELLpALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHLREL 533
Cdd:COG4555 151 PKVLLLDEPTNGLDVMARRLLREILR-ALKKEGKTVLFSSHIMQEVEAlCDRVVILHKGKVVAQ 213
|
|
| cbiO |
PRK13635 |
energy-coupling factor ABC transporter ATP-binding protein; |
322-532 |
4.98e-26 |
|
energy-coupling factor ABC transporter ATP-binding protein;
Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 107.79 E-value: 4.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:PRK13635 6 IRVEHISFRYPDAATY---ALKDVSFSVYEGEWVAIVGHNGSGKSTLAKLLNGLLLPEAGTITVGGMVLSEETVWDVRRQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTD-FHQF-------DRLQGPEG-GEPDTALV--AHW-LERLNMKSKLQFDGARvtnpqLSQGQRKRLALLLAVAE 469
Cdd:PRK13635 83 VGMVFQNpDNQFvgatvqdDVAFGLENiGVPREEMVerVDQaLRQVGMEDFLNREPHR-----LSGGQKQRVAIAGVLAL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 470 QRDILLLDEWAADQDPQFRrifyRELLPALRAL----GKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PRK13635 158 QPDIIILDEATSMLDPRGR----REVLETVRQLkeqkGITVLSITHDLDEAAQADRVIVMNKGEILE 220
|
|
| CydD |
COG4988 |
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ... |
321-532 |
1.40e-25 |
|
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 110.62 E-value: 1.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFHYADAeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR 400
Cdd:COG4988 336 SIELEDVSFSYPGG----RPALDGLSLTIPPGERVALVGPSGAGKSTLLNLLLGFLPPYSGSILINGVDLSDLDPASWRR 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFTDFHQFD-------RLQGPEGGEPD------TALVAHWLERLN--MKSKLQFDGARvtnpqLSQGQRKRLALLL 465
Cdd:COG4988 412 QIAWVPQNPYLFAgtirenlRLGRPDASDEEleaaleAAGLDEFVAALPdgLDTPLGEGGRG-----LSGGQAQRLALAR 486
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 466 AVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:COG4988 487 ALLRDAPLLLLDEPTAHLDAETE----AEILQALRRLakGRTVILITHRLALLAQADRILVLDDGRIVE 551
|
|
| ABC_Class3 |
cd03229 |
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
322-529 |
1.71e-25 |
|
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 103.04 E-value: 1.71e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYR 399
Cdd:cd03229 1 LELKNVSKRYGQK-----TVLNDVSLNIEAGEIVALLGPSGSGKSTLLRCIAGLEEPDSGSILIDGedLTDLEDELPPLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDFhqfdrlqgpeggepdtALVAHwlerLNMKSKLQFdgarvtnpQLSQGQRKRLALLLAVAEQRDILLLDEW 479
Cdd:cd03229 76 RRIGMVFQDF----------------ALFPH----LTVLENIAL--------GLSGGQQQRVALARALAMDPDVLLLDEP 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 612265813 480 AADQDPQFRRIFyRELLPALRA-LGKTVFAISHDDHYFEH-ADRLLEMRSGH 529
Cdd:cd03229 128 TSALDPITRREV-RALLKSLQAqLGITVVLVTHDLDEAARlADRVVVLRDGK 178
|
|
| ECF_ATPase_1 |
TIGR04520 |
energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ... |
322-539 |
3.94e-25 |
|
energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 275313 [Multi-domain] Cd Length: 268 Bit Score: 104.82 E-value: 3.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV-AQTAADMPDYRR 400
Cdd:TIGR04520 1 IEVENVSFSYPESEKP---ALKNVSLSIEKGEFVAIIGHNGSGKSTLAKLLNGLLLPTSGKVTVDGLdTLDEENLWEIRK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFT--DfHQF-------DRLQGPE--GGEPDT--ALVAHWLERLNMKSKLQFdgarvtNPQ-LSQGQRKRLALLLA 466
Cdd:TIGR04520 78 KVGMVFQnpD-NQFvgatvedDVAFGLEnlGVPREEmrKRVDEALKLVGMEDFRDR------EPHlLSGGQKQRVAIAGV 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 467 VAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL----GKTVFAISHDDHYFEHADRLLEMRSGHLReLTGSERE 539
Cdd:TIGR04520 151 LAMRPDIIILDEATSMLDPKGR----KEVLETIRKLnkeeGITVISITHDMEEAVLADRVIVMNKGKIV-AEGTPRE 222
|
|
| CcmA |
COG1131 |
ABC-type multidrug transport system, ATPase component [Defense mechanisms]; |
322-530 |
5.30e-25 |
|
ABC-type multidrug transport system, ATPase component [Defense mechanisms];
Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 103.60 E-value: 5.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpgFT-VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaQTAADMPDYRR 400
Cdd:COG1131 1 IEVRGLTKRYGD------KTaLDGVSLTVEPGEIFGLLGPNGAGKTTTIRMLLGLLRPTSGEVRVLGE-DVARDPAEVRR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFTDFHQFDRLQGPE-----------GGEPDTALVAHWLERLNMKSKLqfdGARVTNpqLSQGQRKRLALLLAVAE 469
Cdd:COG1131 74 RIGYVPQEPALYPDLTVREnlrffarlyglPRKEARERIDELLELFGLTDAA---DRKVGT--LSGGMKQRLGLALALLH 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFyRELLPALRALGKTVFAIShddHYFEHA----DRLLEMRSGHL 530
Cdd:COG1131 149 DPELLILDEPTSGLDPEARREL-WELLRELAAEGKTVLLST---HYLEEAerlcDRVAIIDKGRI 209
|
|
| ABC_MJ0796_LolCDE_FtsE |
cd03255 |
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
322-530 |
1.29e-24 |
|
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.
Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 101.80 E-value: 1.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeQQPGFTVGPL---NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPD- 397
Cdd:cd03255 1 IELKNLSKTY----GGGGEKVQALkgvSLSIEKGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVRVDG--TDISKLSEk 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 ----YRRL-FSAIFTDFHQFDRL------------QGPEGGEPDtALVAHWLERLNMKSKLqfdGARVTnpQLSQGQRKR 460
Cdd:cd03255 75 elaaFRRRhIGFVFQSFNLLPDLtalenvelplllAGVPKKERR-ERAEELLERVGLGDRL---NHYPS--ELSGGQQQR 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 461 LALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:cd03255 149 VAIARALANDPKIILADEPTGNLDSETGKEVMELLRELNKEAGTTIVVVTHDPELAEYADRIIELRDGKI 218
|
|
| CydC |
TIGR02868 |
thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ... |
173-512 |
1.38e-24 |
|
thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.
Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 107.45 E-value: 1.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 173 RHMASLRESEERLYHRYESVIDGRKELTLN--RKRAQALYEQAyqpDAQAyryhiIRADTFHLSALNWSNIMMLGAIGLV 250
Cdd:TIGR02868 180 AAEQALARLRGELAAQLTDALDGAAELVASgaLPAALAQVEEA---DREL-----TRAERRAAAATALGAALTLLAAGLA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 251 FFMANSLG---WADSTVAATYSLTLLFLRTPLLQAVGAFPTLVGAEVAFnKLKALRLAEYQSG--------FPAAVGRSW 319
Cdd:TIGR02868 252 VLGALWAGgpaVADGRLAPVTLAVLVLLPLAAFEAFAALPAAAQQLTRV-RAAAERIVEVLDAagpvaegsAPAAGAVGL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 Q--TLELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPD 397
Cdd:TIGR02868 331 GkpTLELRDLSAGYPGAPP----VLDGVSLDLPPGERVAILGPSGSGKSTLLATLAGLLDPLQGEVTLDGVPVSSLDQDE 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRRLFSAIFTDFHQFD-------RLQGPEGGEPD--TAL----VAHWLERL--NMKSKLQFDGARvtnpqLSQGQRKRLA 462
Cdd:TIGR02868 407 VRRRVSVCAQDAHLFDttvrenlRLARPDATDEElwAALervgLADWLRALpdGLDTVLGEGGAR-----LSGGERQRLA 481
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRalGKTVFAISHD 512
Cdd:TIGR02868 482 LARALLADAPILLLDEPTEHLDAETADELLEDLLAALS--GRTVVLITHH 529
|
|
| GsiA |
COG1123 |
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
322-532 |
5.29e-24 |
|
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 105.37 E-value: 5.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV---AQTAADMPDY 398
Cdd:COG1123 261 LEVRNLSKRYPVRGKGGVRAVDDVSLTLRRGETLGLVGESGSGKSTLARLLLGLLRPTSGSILFDGKdltKLSRRSLREL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAIFTD-FHQFD-------------RLQGPEGGEPDTALVAHWLERLNMKSKLqfdGARvtNP-QLSQGQRKRLAL 463
Cdd:COG1123 341 RRRVQMVFQDpYSSLNprmtvgdiiaeplRLHGLLSRAERRERVAELLERVGLPPDL---ADR--YPhELSGGQRQRVAI 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 464 LLAVAEQRDILLLDEWAADQDPQFR-RIFyrELLPALRA-LGKTVFAISHD----DHYfehADRLLEMRSGHLRE 532
Cdd:COG1123 416 ARALALEPKLLILDEPTSALDVSVQaQIL--NLLRDLQReLGLTYLFISHDlavvRYI---ADRVAVMYDGRIVE 485
|
|
| ABC_NrtD_SsuB_transporters |
cd03293 |
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
322-532 |
5.46e-24 |
|
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 100.24 E-value: 5.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqQPGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadmPDYRR 400
Cdd:cd03293 1 LEVRNVSKTYGGG--GGAVTAlEDISLSVEEGEFVALVGPSGCGKSTLLRIIAGLERPTSGEVLVDGEPVTG---PGPDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFsaIFTDFHQFD------------RLQGPEGGEPDtALVAHWLERLNMKSklqFDGARvtnP-QLSQGQRKRLALLLAV 467
Cdd:cd03293 76 GY--VFQQDALLPwltvldnvalglELQGVPKAEAR-ERAEELLELVGLSG---FENAY---PhQLSGGMRQRVALARAL 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 468 AEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEM--RSGHLRE 532
Cdd:cd03293 147 AVDPDVLLLDEPFSALDALTREQLQEELLDIWRETGKTVLLVTHDiDEAVFLADRVVVLsaRPGRIVA 214
|
|
| ZnuC |
COG1121 |
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ... |
322-532 |
9.60e-24 |
|
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];
Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 100.16 E-value: 9.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG------------VA 389
Cdd:COG1121 7 IELENLTVSY---GGRP--VLEDVSLTIPPGEFVAIVGPNGAGKSTLLKAILGLLPPTSGTVRLFGkpprrarrrigyVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 390 QTAA---DMP-----------DYRRLFsaiftdfhqFDRLqgpegGEPDTALVAHWLERLNMkskLQFDGARVTnpQLSQ 455
Cdd:COG1121 82 QRAEvdwDFPitvrdvvlmgrYGRRGL---------FRRP-----SRADREAVDEALERVGL---EDLADRPIG--ELSG 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 456 GQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLRE 532
Cdd:COG1121 143 GQQQRVLLARALAQDPDLLLLDEPFAGVDAATEEALY-ELLRELRREGKTILVVTHDlGAVREYFDRVLLLNRGLVAH 219
|
|
| LolD |
COG1136 |
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; |
322-532 |
4.03e-23 |
|
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 97.81 E-value: 4.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV---AQTAADMPD 397
Cdd:COG1136 5 LELRNLTKSYGTGEGE--VTAlRGVSLSIEAGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVLIDGQdisSLSERELAR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRR-LFSAIFTDFHQFDRL------------QGPEGGEpDTALVAHWLERLNMKSKLQfdgARVTnpQLSQGQRKRLALL 464
Cdd:COG1136 83 LRRrHIGFVFQFFNLLPELtalenvalplllAGVSRKE-RRERARELLERVGLGDRLD---HRPS--QLSGGQQQRVAIA 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 465 LAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:COG1136 157 RALVNRPKLILADEPTGNLDSKTGEEVLELLRELNRELGTTIVMVTHDPELAARADRVIRLRDGRIVS 224
|
|
| ABC_Carb_Solutes_like |
cd03259 |
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ... |
322-530 |
4.14e-23 |
|
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 97.59 E-value: 4.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRL 401
Cdd:cd03259 1 LELKGLSKTYGSV-----RALDDLSLTVEPGEFLALLGPSGCGKTTLLRLIAGLERPDSGEILIDG--RDVTGVPPERRN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQGPE--------GGEPDTALVAHWLERLNMKSKLQFDGARVTnpQLSQGQRKRLALLLAVAEQRDI 473
Cdd:cd03259 74 IGMVFQDYALFPHLTVAEniafglklRGVPKAEIRARVRELLELVGLEGLLNRYPH--ELSGGQQQRVALARALAREPSL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 474 LLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03259 152 LLLDEPLSALDAKLREELREELKELQRELGITTIYVTHDqEEALALADRIAVMNEGRI 209
|
|
| CcmA |
COG4133 |
ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
344-522 |
5.02e-23 |
|
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 97.16 E-value: 5.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 344 PLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF-----SAIFTD--------FH 410
Cdd:COG4133 20 GLSFTLAAGEALALTGPNGSGKTTLLRILAGLLPPSAGEVLWNGEPIRDAREDYRRRLAylghaDGLKPEltvrenlrFW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 411 QfdRLQGPeggEPDTALVAHWLERLNMksklqfdGARVTNP--QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFR 488
Cdd:COG4133 100 A--ALYGL---RADREAIDEALEAVGL-------AGLADLPvrQLSAGQKRRVALARLLLSPAPLWLLDEPFTALDAAGV 167
|
170 180 190
....*....|....*....|....*....|....
gi 612265813 489 RIFYrELLPALRALGKTVFAISHDDHYFEHADRL 522
Cdd:COG4133 168 ALLA-ELIAAHLARGGAVLLTTHQPLELAAARVL 200
|
|
| ABCC_Protease_Secretion |
cd03246 |
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
322-528 |
7.58e-23 |
|
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA.
Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 95.36 E-value: 7.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03246 1 LEVENVSFRYPGAEP---PVLRNVSFSIEPGESLAIIGPSGSGKSTLARLILGLLRPTSGRVRLDGADISQWDPNELGDH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDfhqfDRLqgpeggepdtalvahwlerlnmksklqFDGARVTNPqLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03246 78 VGYLPQD----DEL---------------------------FSGSIAENI-LSGGQRQRLGLARALYGNPRILVLDEPNS 125
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 612265813 482 DQDPQFRRIFYrELLPALRALGKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:cd03246 126 HLDVEGERALN-QAIAALKAAGATRIVIAHRPETLASADRILVLEDG 171
|
|
| GsiA |
COG1123 |
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
322-532 |
2.54e-22 |
|
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 100.36 E-value: 2.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRP---VSGHIVLDGVAQTAADMPDY 398
Cdd:COG1123 5 LEVRDLSVRYPGGDV---PAVDGVSLTIAPGETVALVGESGSGKSTLALALMGLLPHggrISGEVLLDGRDLLELSEALR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAIFTDF-HQFDRLqgPEGGEPDTALVAHWLERLNMKSK-------LQFDGARVTNP-QLSQGQRKRLALLLAVAE 469
Cdd:COG1123 82 GRRIGMVFQDPmTQLNPV--TVGDQIAEALENLGLSRAEARARvlelleaVGLERRLDRYPhQLSGGQRQRVAIAMALAL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLRE 532
Cdd:COG1123 160 DPDLLIADEPTTALDVTTQAEILDLLRELQRERGTTVLLITHDlGVVAEIADRVVVMDDGRIVE 223
|
|
| ABC_Iron-Siderophores_B12_Hemin |
cd03214 |
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ... |
323-530 |
4.95e-22 |
|
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.
Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 93.27 E-value: 4.95e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYadaeqQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPdyrrlf 402
Cdd:cd03214 1 EVENLSVGY-----GGRTVLDDLSLSIEAGEIVGILGPNGAGKSTLLKTLAGLLKPSSGEILLDG--KDLASLS------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 saiftdFHQFDRLqgpeggepdTALVAHWLERLNMKSKLQfdgaRVTNpQLSQGQRKRLALLLAVAEQRDILLLDEWAAD 482
Cdd:cd03214 68 ------PKELARK---------IAYVPQALELLGLAHLAD----RPFN-ELSGGERQRVLLARALAQEPPILLLDEPTSH 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 612265813 483 QDpqfrrIFYR-ELLPALRAL----GKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03214 128 LD-----IAHQiELLELLRRLarerGKTVVMVLHDlNLAARYADRVILLKDGRI 176
|
|
| cbiO |
PRK13632 |
cobalt transporter ATP-binding subunit; Provisional |
323-530 |
3.80e-21 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 93.52 E-value: 3.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEQqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:PRK13632 9 KVENVSFSYPNSEN---NALKNVSFEINEGEYVAILGHNGSGKSTISKILTGLLKPQSGEIKIDGITISKENLKEIRKKI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFtdfhqfdrlQGPEGG------EPDTA---------------LVAHWLERLNMKSKLQFDgarvtnPQ-LSQGQRKR 460
Cdd:PRK13632 86 GIIF---------QNPDNQfigatvEDDIAfglenkkvppkkmkdIIDDLAKKVGMEDYLDKE------PQnLSGGQKQR 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 461 LALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALG-KTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:PRK13632 151 VAIASVLALNPEIIIFDESTSMLDPKGKREIK-KIMVDLRKTRkKTLISITHDMDEAILADKVIVFSEGKL 220
|
|
| ABC_Org_Solvent_Resistant |
cd03261 |
ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
322-530 |
4.23e-21 |
|
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 92.18 E-value: 4.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpgFTV--GpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYR 399
Cdd:cd03261 1 IELRGLTKSFGG------RTVlkG-VDLDVRRGEILAIIGPSGSGKSTLLRLIVGLLRPDSGEVLIDGEDISGLSEAELY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RL---------FSAIFTDFHQFDRLQGP---EGGEPD---TALVAHWLERLNMKsklqfdGARVTNP-QLSQGQRKRLAL 463
Cdd:cd03261 74 RLrrrmgmlfqSGALFDSLTVFENVAFPlreHTRLSEeeiREIVLEKLEAVGLR------GAEDLYPaELSGGMKKRVAL 147
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 464 LLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDH-YFEHADRLLEMRSGHL 530
Cdd:cd03261 148 ARALALDPELLLYDEPTAGLDPIASGVIDDLIRSLKKELGLTSIMVTHDLDtAFAIADRIAVLYDGKI 215
|
|
| DppF |
COG1124 |
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ... |
322-538 |
6.78e-21 |
|
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];
Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 92.17 E-value: 6.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:COG1124 2 LEVRNLSVSYGQGGRRV-PVLKDVSLEVAPGESFGLVGESGSGKSTLLRALAGLERPWSGEVTFDGRPVTRRRRKAFRRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTD-------FHQFDR-LQGP--EGGEPDT-ALVAHWLERLNMKSKLQFdgaRvtNP-QLSQGQRKRLALLLAVAE 469
Cdd:COG1124 81 VQMVFQDpyaslhpRHTVDRiLAEPlrIHGLPDReERIAELLEQVGLPPSFLD---R--YPhQLSGGQRQRVAIARALIL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612265813 470 QRDILLLDEWAADQDP--QFRRIfyrELLPALRA-LGKTVFAISHDDHYFEH-ADRLLEMRSGHLRELTGSER 538
Cdd:COG1124 156 EPELLLLDEPTSALDVsvQAEIL---NLLKDLREeRGLTYLFVSHDLAVVAHlCDRVAVMQNGRIVEELTVAD 225
|
|
| FepC |
COG1120 |
ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ... |
322-530 |
1.51e-20 |
|
ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];
Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 91.26 E-value: 1.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:COG1120 2 LEAENLSVGYGGRP-----VLDDVSLSLPPGEVTALLGPNGSGKSTLLRALAGLLKPSSGEVLLDGRDLASLSRRELARR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRL-------------QGPEGGEP--DTALVAHWLERLNMkskLQFDGARVTnpQLSQGQRKRLALLLA 466
Cdd:COG1120 77 IAYVPQEPPAPFGLtvrelvalgryphLGLFGRPSaeDREAVEEALERTGL---EHLADRPVD--ELSGGERQRVLIARA 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 467 VAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL----GKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG1120 152 LAQEPPLLLLDEPTSHLDLAHQ----LEVLELLRRLarerGRTVVMVLHDlNLAARYADRLVLLKDGRI 216
|
|
| ABC_Mj1267_LivG_branched |
cd03219 |
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
322-528 |
1.53e-20 |
|
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).
Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 90.57 E-value: 1.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYAdaeqqpGFT-VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadMPDYRR 400
Cdd:cd03219 1 LEVRGLTKRFG------GLVaLDDVSFSVRPGEIHGLIGPNGAGKTTLFNLISGFLRPTSGSVLFDGEDITG--LPPHEI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 -------------LFS-----------AIFTDFHQFDRLQGPEGGEPDTALVAHWLERLNMKSKlqfdgARVTNPQLSQG 456
Cdd:cd03219 73 arlgigrtfqiprLFPeltvlenvmvaAQARTGSGLLLARARREEREARERAEELLERVGLADL-----ADRPAGELSYG 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612265813 457 QRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFyRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:cd03219 148 QQRRLEIARALATDPKLLLLDEPAAGLNPEETEEL-AELIRELRERGITVLLVEHDmDVVMSLADRVTVLDQG 219
|
|
| cbiO |
PRK13650 |
energy-coupling factor transporter ATPase; |
322-545 |
2.27e-20 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 91.33 E-value: 2.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:PRK13650 5 IEVKNLTFKYKEDQEKY--TLNDVSFHVKQGEWLSIIGHNGSGKSTTVRLIDGLLEAESGQIIIDGDLLTEENVWDIRHK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFtdfhqfdrlQGPEGG------EPDTA--LVAHWLERLNMKSK----LQFDGA---RVTNP-QLSQGQRKRLALLL 465
Cdd:PRK13650 83 IGMVF---------QNPDNQfvgatvEDDVAfgLENKGIPHEEMKERvneaLELVGMqdfKEREPaRLSGGQKQRVAIAG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 466 AVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL----GKTVFAISHDDHYFEHADRLLEMRSGHLrELTGSEREHA 541
Cdd:PRK13650 154 AVAMRPKIIILDEATSMLDPEGR----LELIKTIKGIrddyQMTVISITHDLDEVALSDRVLVMKNGQV-ESTSTPRELF 228
|
....
gi 612265813 542 SRDS 545
Cdd:PRK13650 229 SRGN 232
|
|
| ABC_Carb_Monos_I |
cd03216 |
First domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
322-530 |
2.27e-20 |
|
First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.
Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 88.25 E-value: 2.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeqqPGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR 400
Cdd:cd03216 1 LELRGITKRF------GGVKAlDGVSLSVRRGEVHALLGENGAGKSTLMKILSGLYKPDSGEILVDGKEVSFASPRDARR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LfsAIftdfhqfdrlqgpeggepdtALVahwlerlnmksklqfdgarvtnPQLSQGQRKRLALLLAVAEQRDILLLDE-W 479
Cdd:cd03216 75 A--GI--------------------AMV----------------------YQLSVGERQMVEIARALARNARLLILDEpT 110
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 612265813 480 AADQDPQFRRIFyrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03216 111 AALTPAEVERLF--KVIRRLRAQGVAVIFISHRlDEVFEIADRVTVLRDGRV 160
|
|
| FtsE |
COG2884 |
Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning]; |
345-532 |
2.43e-20 |
|
Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 89.73 E-value: 2.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV---AQTAADMPDYRRLFSAIFTDFHQFD-------- 413
Cdd:COG2884 21 VSLEIEKGEFVFLTGPSGAGKSTLLKLLYGEERPTSGQVLVNGQdlsRLKRREIPYLRRRIGVVFQDFRLLPdrtvyenv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 414 ----RLQGPEGGEpDTALVAHWLERLNMKSKlqfdgARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQF-R 488
Cdd:COG2884 101 alplRVTGKSRKE-IRRRVREVLDLVGLSDK-----AKALPHELSGGEQQRVAIARALVNRPELLLADEPTGNLDPETsW 174
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 612265813 489 RIFyrELLPALRALGKTVFAISHDDHYFEHAD-RLLEMRSGHLRE 532
Cdd:COG2884 175 EIM--ELLEEINRRGTTVLIATHDLELVDRMPkRVLELEDGRLVR 217
|
|
| TauB |
COG1116 |
ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ... |
322-512 |
5.34e-20 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism];
Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 89.76 E-value: 5.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadmPDYRR 400
Cdd:COG1116 8 LELRGVSKRFPTGGG--GVTAlDDVSLTVAAGEFVALVGPSGCGKSTLLRLIAGLEKPTSGEVLVDGKPVTG---PGPDR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFsaIFTDFHQFD------------RLQGPEGGEpDTALVAHWLERLNMKsklQFDGARvtnP-QLSQGQRKRLALLLAV 467
Cdd:COG1116 83 GV--VFQEPALLPwltvldnvalglELRGVPKAE-RRERARELLELVGLA---GFEDAY---PhQLSGGMRQRVAIARAL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 612265813 468 AEQRDILLLDE-WAAdQDPQFRRIFYRELLPALRALGKTVFAISHD 512
Cdd:COG1116 154 ANDPEVLLMDEpFGA-LDALTRERLQDELLRLWQETGKTVLFVTHD 198
|
|
| ABCC_Glucan_exporter_like |
cd03254 |
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ... |
323-539 |
7.24e-20 |
|
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 88.44 E-value: 7.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYAdaEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:cd03254 4 EFENVNFSYD--EKKP--VLKDINFSIKPGETVAIVGPTGAGKTTLINLLMRFYDPQKGQILIDGIDIRDISRKSLRSMI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFTDFHQFD-------RLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQ---LSQGQRKRLALLLAVAEQRD 472
Cdd:cd03254 80 GVVLQDTFLFSgtimeniRLGRPNATDEEVIEAAKEAGAHDFIMKLPNGYDTVLGENggnLSQGERQLLAIARAMLRDPK 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 473 ILLLDEWAADQDPQFRRIFYRellpALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRElTGSERE 539
Cdd:cd03254 160 ILILDEATSNIDTETEKLIQE----ALEKLmkGRTSIIIAHRLSTIKNADKILVLDDGKIIE-EGTHDE 223
|
|
| ABC_Metallic_Cations |
cd03235 |
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
345-525 |
1.02e-19 |
|
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.
Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 87.59 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG------------VAQTA---ADMP-----------DY 398
Cdd:cd03235 18 VSFEVKPGEFLAIVGPNGAGKSTLLKAILGLLKPTSGSIRVFGkplekerkrigyVPQRRsidRDFPisvrdvvlmglYG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAIFTdfhqfdrlqgpeggEPDTALVAHWLERLNMKSKL--QFDgarvtnpQLSQGQRKRLALLLAVAEQRDILLL 476
Cdd:cd03235 98 HKGLFRRLS--------------KADKAKVDEALERVGLSELAdrQIG-------ELSGGQQQRVLLARALVQDPDLLLL 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 477 DEWAADQDPQFRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEM 525
Cdd:cd03235 157 DEPFAGVDPKTQEDIY-ELLRELRREGMTILVVTHDlGLVLEYFDRVLLL 205
|
|
| ABCC_MsbA |
cd03251 |
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ... |
322-546 |
1.15e-19 |
|
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 88.06 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03251 1 VEFKNVTFRYPGDG---PPVLRDISLDIPAGETVALVGPSGSGKSTLVNLIPRFYDVDSGRILIDGHDVRDYTLASLRRQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFD-------RLQGPEGGEPD---TALVAHWLERLnMKSKLQFD---GARVTNpqLSQGQRKRLALLLAVA 468
Cdd:cd03251 78 IGLVSQDVFLFNdtvaeniAYGRPGATREEveeAARAANAHEFI-MELPEGYDtviGERGVK--LSGGQRQRIAIARALL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 469 EQRDILLLDEWAADQDPQFRRIFYRellpALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRElTGSEREHASRDSV 546
Cdd:cd03251 155 KDPPILILDEATSALDTESERLVQA----ALERLmkNRTTFVIAHRLSTIENADRIVVLEDGKIVE-RGTHEELLAQGGV 229
|
|
| ABCC_bacteriocin_exporters |
cd03245 |
ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ... |
322-528 |
1.70e-19 |
|
ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane.
Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 87.26 E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03245 3 IEFRNVSFSYPNQEIP---ALDNVSLTIRAGEKVAIIGRVGSGKSTLLKLLAGLYKPTSGSVLLDGTDIRQLDPADLRRN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFD-------RLQGPEGgepDTALVahwLERLNMKSKLQF-------------DGARvtnpQLSQGQRKRL 461
Cdd:cd03245 80 IGYVPQDVTLFYgtlrdniTLGAPLA---DDERI---LRAAELAGVTDFvnkhpngldlqigERGR----GLSGGQRQAV 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 462 ALLLAVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL--GKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:cd03245 150 ALARALLNDPPILLLDEPTSAMDMNSE----ERLKERLRQLlgDKTLIIITHRPSLLDLVDRIIVMDSG 214
|
|
| MsbA_lipidA |
TIGR02203 |
lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide ... |
314-546 |
1.88e-19 |
|
lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide chain transporter in the ATP-binding cassette (ABC) transporter family, MsbA, which exports lipid A. It may also act in multidrug resistance. Lipid A, a part of lipopolysaccharide, is found in the outer leaflet of the outer membrane of most Gram-negative bacteria. Members of this family are restricted to the Proteobacteria (although lipid A is more broadly distributed) and often are clustered with lipid A biosynthesis genes. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Pssm-ID: 131258 [Multi-domain] Cd Length: 571 Bit Score: 91.70 E-value: 1.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 314 AVGRSWQTLELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAA 393
Cdd:TIGR02203 323 AIERARGDVEFRNVTFRYPGRDRP---ALDSISLVIEPGETVALVGRSGSGKSTLVNLIPRFYEPDSGQILLDGHDLADY 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 394 DMPDYRRLFSAIFTDFHQFD----------RLQGPEGGEPDTALVAHWLERLNMKSKLQFD------GARvtnpqLSQGQ 457
Cdd:TIGR02203 400 TLASLRRQVALVSQDVVLFNdtianniaygRTEQADRAEIERALAAAYAQDFVDKLPLGLDtpigenGVL-----LSGGQ 474
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 458 RKRLALLLAVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRElTG 535
Cdd:TIGR02203 475 RQRLAIARALLKDAPILILDEATSALDNESE----RLVQAALERLmqGRTTLVIAHRLSTIEKADRIVVMDDGRIVE-RG 549
|
250
....*....|.
gi 612265813 536 SEREHASRDSV 546
Cdd:TIGR02203 550 THNELLARNGL 560
|
|
| ABC_NikE_OppD_transporters |
cd03257 |
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
322-532 |
2.27e-19 |
|
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.
Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 87.18 E-value: 2.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD---MPDY 398
Cdd:cd03257 2 LEVKNLSVSFPT-GGGSVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKPTSGSIIFDGKDLLKLSrrlRKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAIFTDfhqfdrlqgpeggePDTAL---------VAHWLERLNMKSKLQFDGARVTN---------------P-QL 453
Cdd:cd03257 81 RKEIQMVFQD--------------PMSSLnprmtigeqIAEPLRIHGKLSKKEARKEAVLLllvgvglpeevlnryPhEL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 454 SQGQRKRLALLLAVAEQRDILLLDE--WAADQDPQFRRIfyrELLPALRA-LGKTVFAISHDDHYFEH-ADRLLEMRSGH 529
Cdd:cd03257 147 SGGQRQRVAIARALALNPKLLIADEptSALDVSVQAQIL---DLLKKLQEeLGLTLLFITHDLGVVAKiADRVAVMYAGK 223
|
...
gi 612265813 530 LRE 532
Cdd:cd03257 224 IVE 226
|
|
| potG |
PRK11607 |
putrescine ABC transporter ATP-binding subunit PotG; |
342-550 |
3.89e-19 |
|
putrescine ABC transporter ATP-binding subunit PotG;
Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 89.51 E-value: 3.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRLFSAIFTDFHQF--------- 412
Cdd:PRK11607 35 VDDVSLTIYKGEIFALLGASGCGKSTLLRMLAGFEQPTAGQIMLDG--VDLSHVPPYQRPINMMFQSYALFphmtveqni 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 ------DRLQGPEggepDTALVAHWLERLNMKsklQFdgARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:PRK11607 113 afglkqDKLPKAE----IASRVNEMLGLVHMQ---EF--AKRKPHQLSGGQRQRVALARSLAKRPKLLLLDEPMGALDKK 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 487 FRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLRELTGSER--EH-ASRDSVSRIG 550
Cdd:PRK11607 184 LRDRMQLEVVDILERVGVTCVMVTHDqEEAMTMAGRIAIMNRGKFVQIGEPEEiyEHpTTRYSAEFIG 251
|
|
| MlaF |
COG1127 |
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ... |
322-521 |
6.36e-19 |
|
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 86.19 E-value: 6.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpgFTV--GpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYR 399
Cdd:COG1127 6 IEVRNLTKSFGD------RVVldG-VSLDVPRGEILAIIGGSGSGKSVLLKLIIGLLRPDSGEILVDGQDITGLSEKELY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RL---------FSAIFTDFHQFDRLQGP--EGGE-PDT---ALVAHWLERLNMKsklqfdGARVTNP-QLSQGQRKRLAL 463
Cdd:COG1127 79 ELrrrigmlfqGGALFDSLTVFENVAFPlrEHTDlSEAeirELVLEKLELVGLP------GAADKMPsELSGGMRKRVAL 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 464 LLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALR-ALGKTVFAISHDDHY-FEHADR 521
Cdd:COG1127 153 ARALALDPEILLYDEPTAGLDPITSAVID-ELIRELRdELGLTSVVVTHDLDSaFAIADR 211
|
|
| cbiO |
PRK13642 |
energy-coupling factor transporter ATPase; |
320-546 |
8.63e-19 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 86.69 E-value: 8.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 QTLELRDVVFHY---ADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMP 396
Cdd:PRK13642 3 KILEVENLVFKYekeSDVNQLNG-----VSFSITKGEWVSIIGQNGSGKSTTARLIDGLFEEFEGKVKIDGELLTAENVW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 397 DYRRLFSAIFTD-FHQF-------DRLQGPEG-GEPDTALVAHWLERLNMKSKLQFdgaRVTNP-QLSQGQRKRLALLLA 466
Cdd:PRK13642 78 NLRRKIGMVFQNpDNQFvgatvedDVAFGMENqGIPREEMIKRVDEALLAVNMLDF---KTREPaRLSGGQKQRVAVAGI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 467 VAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGH-LRELTGSEREHASRDS 545
Cdd:PRK13642 155 IALRPEIIILDESTSMLDPTGRQEIMRVIHEIKEKYQLTVLSITHDLDEAASSDRILVMKAGEiIKEAAPSELFATSEDM 234
|
.
gi 612265813 546 V 546
Cdd:PRK13642 235 V 235
|
|
| ABC_PhnC_transporter |
cd03256 |
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ... |
346-529 |
1.08e-18 |
|
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 85.31 E-value: 1.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTA---ADMPDYRRLFSAIFTDFHQFDRLQGPEG-- 420
Cdd:cd03256 21 SLSINPGEFVALIGPSGAGKSTLLRCLNGLVEPTSGSVLIDGTDINKlkgKALRQLRRQIGMIFQQFNLIERLSVLENvl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 -----------------GEPDTALVAHWLERLNMKSKLQfdgARVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQ 483
Cdd:cd03256 101 sgrlgrrstwrslfglfPKEEKQRALAALERVGLLDKAY---QRAD--QLSGGQQQRVAIARALMQQPKLILADEPVASL 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 612265813 484 DPQFRRIFYRELLPALRALGKTVFAISHDDHYF-EHADRLLEMRSGH 529
Cdd:cd03256 176 DPASSRQVMDLLKRINREEGITVIVSLHQVDLArEYADRIVGLKDGR 222
|
|
| PotA |
COG3842 |
ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ... |
322-530 |
1.36e-18 |
|
ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];
Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 87.46 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRL 401
Cdd:COG3842 6 LELENVSKRYGDV-----TALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDG--RDVTGLPPEKRN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDF----HQ--FD------RLQGPEGGEPDtALVAHWLERLNMKsklQFDGARVTnpQLSQGQRKRLALLLAVAE 469
Cdd:COG3842 79 VGMVFQDYalfpHLtvAEnvafglRMRGVPKAEIR-ARVAELLELVGLE---GLADRYPH--QLSGGQQQRVALARALAP 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG3842 153 EPRVLLLDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDqEEALALADRIAVMNDGRI 214
|
|
| ABCC_MRP_domain1 |
cd03250 |
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
322-528 |
3.61e-18 |
|
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.
Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 82.90 E-value: 3.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG----VAQTAADMPD 397
Cdd:cd03250 1 ISVEDASFTWDSGEQETSFTLKDINLEVPKGELVAIVGPVGSGKSSLLSALLGELEKLSGSVSVPGsiayVSQEPWIQNG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRR---LFSAIF---------------TDFHQFdrlqgPEGgepDTALVahwlerlnmksklqfdGARVTNpqLSQGQRK 459
Cdd:cd03250 81 TIReniLFGKPFdeeryekvikacalePDLEIL-----PDG---DLTEI----------------GEKGIN--LSGGQKQ 134
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 460 RLALLLAVAEQRDILLLDewaadqDPqF--------RRIFYRELLPALRaLGKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:cd03250 135 RISLARAVYSDADIYLLD------DP-LsavdahvgRHIFENCILGLLL-NNKTRILVTHQLQLLPHADQIVVLDNG 203
|
|
| Uup |
COG0488 |
ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
322-536 |
5.17e-18 |
|
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];
Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 87.04 E-value: 5.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqQPGFTvgPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVL-DGV-----AQTAADM 395
Cdd:COG0488 316 LELEGLSKSYGD---KTLLD--DLSLRIDRGDRIGLIGPNGAGKSTLLKLLAGELEPDSGTVKLgETVkigyfDQHQEEL 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 PDYRRLFSAIftdfhqfdRLQGPEGGEPDtalVAHWLERLNmksklqFDGARVTNP--QLSQGQRKRLALLLAVAEQRDI 473
Cdd:COG0488 391 DPDKTVLDEL--------RDGAPGGTEQE---VRGYLGRFL------FSGDDAFKPvgVLSGGEKARLALAKLLLSPPNV 453
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 474 LLLDEWAADQDPQFRRIfyreLLPALRALGKTVFAISHdDHYF--EHADRLLEMRSGHLRELTGS 536
Cdd:COG0488 454 LLLDEPTNHLDIETLEA----LEEALDDFPGTVLLVSH-DRYFldRVATRILEFEDGGVREYPGG 513
|
|
| LivG |
COG0411 |
ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid ... |
345-523 |
1.08e-17 |
|
ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid transport and metabolism];
Pssm-ID: 440180 [Multi-domain] Cd Length: 257 Bit Score: 82.78 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYR-------RLF--SAIFTD------- 408
Cdd:COG0411 23 VSLEVERGEIVGLIGPNGAGKTTLFNLITGFYRPTSGRILFDG--RDITGLPPHRiarlgiaRTFqnPRLFPEltvlenv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 409 ------------FHQFDRLQGPEGGEPD-TALVAHWLERLNMKSKLqfdGARVTNpqLSQGQRKRLALLLAVAEQRDILL 475
Cdd:COG0411 101 lvaaharlgrglLAALLRLPRARREEREaRERAEELLERVGLADRA---DEPAGN--LSYGQQRRLEIARALATEPKLLL 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 476 LDEWAADQDPQFRRIFyRELLPALRA-LGKTVFAISHD-DHYFEHADRLL 523
Cdd:COG0411 176 LDEPAAGLNPEETEEL-AELIRRLRDeRGITILLIEHDmDLVMGLADRIV 224
|
|
| CydD |
TIGR02857 |
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ... |
292-525 |
1.13e-17 |
|
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD
Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 86.19 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 292 AEVAFNKLKAL---RLAEYQSGFPAAVGRSWQtLELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTL 368
Cdd:TIGR02857 290 GVAAAEALFAVldaAPRPLAGKAPVTAAPASS-LEFSGVSVAYPGRRP----ALRPVSFTVPPGERVALVGPSGAGKSTL 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 369 AMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR----------LFSAIFTDFHQFDRLQGPEgGEPDTALVAHWLERL--- 435
Cdd:TIGR02857 365 LNLLLGFVDPTEGSIAVNGVPLADADADSWRDqiawvpqhpfLFAGTIAENIRLARPDASD-AEIREALERAGLDEFvaa 443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 436 ---NMKSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRalGKTVFAISHD 512
Cdd:TIGR02857 444 lpqGLDTPIGEGGAG-----LSGGQAQRLALARAFLRDAPLLLLDEPTAHLDAETEAEVLEALRALAQ--GRTVLLVTHR 516
|
250
....*....|...
gi 612265813 513 DHYFEHADRLLEM 525
Cdd:TIGR02857 517 LALAALADRIVVL 529
|
|
| cbiO |
PRK13644 |
energy-coupling factor transporter ATPase; |
322-550 |
1.87e-17 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 82.73 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqQPGFTvgPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV-AQTAADMPDYRR 400
Cdd:PRK13644 2 IRLENVSYSYPDG--TPALE--NINLVIKKGEYIGIIGKNGSGKSTLALHLNGLLRPQKGKVLVSGIdTGDFSKLQGIRK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFTDFH-QF-------DRLQGPEG---------GEPDTALVAHWLERLNMKSKLQFDGArvtnpqlsQGQRKRLAL 463
Cdd:PRK13644 78 LVGIVFQNPEtQFvgrtveeDLAFGPENlclppieirKRVDRALAEIGLEKYRHRSPKTLSGG--------QGQCVALAG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 464 LLAVaeQRDILLLDEWAADQDPQFRRIFYRElLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLReLTGSEREHASR 543
Cdd:PRK13644 150 ILTM--EPECLIFDEVTSMLDPDSGIAVLER-IKKLHEKGKTIVYITHNLEELHDADRIIVMDRGKIV-LEGEPENVLSD 225
|
....*..
gi 612265813 544 DSVSRIG 550
Cdd:PRK13644 226 VSLQTLG 232
|
|
| ThiQ |
COG3840 |
ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism]; |
322-512 |
2.56e-17 |
|
ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];
Pssm-ID: 443051 [Multi-domain] Cd Length: 232 Bit Score: 81.34 E-value: 2.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaaDMPDYRRL 401
Cdd:COG3840 2 LRLDDLTYRYGDFPLR-------FDLTIAAGERVAILGPSGAGKSTLLNLIAGFLPPDSGRILWNGQDLT--ALPPAERP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTD---FHQFD-------------RLqgpegGEPDTALVAHWLERLNMKSKLQFDGArvtnpQLSQGQRKRLALLL 465
Cdd:COG3840 73 VSMLFQEnnlFPHLTvaqniglglrpglKL-----TAEQRAQVEQALERVGLAGLLDRLPG-----QLSGGQRQRVALAR 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 466 AVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL----GKTVFAISHD 512
Cdd:COG3840 143 CLVRKRPILLLDEPFSALDPALR----QEMLDLVDELcrerGLTVLMVTHD 189
|
|
| ABCC_cytochrome_bd |
cd03247 |
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
322-532 |
2.96e-17 |
|
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism.
Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 79.66 E-value: 2.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaQTAADMPDYRRL 401
Cdd:cd03247 1 LSINNVSFSYPEQEQQ---VLKNLSLELKQGEKIALLGRSGSGKSTLLQLLTGDLKPQQGEITLDGV-PVSDLEKALSSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFdrlqgpeggepDTALvahwleRLNMksklqfdGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03247 77 ISVLNQRPYLF-----------DTTL------RNNL-------GRR-----FSGGERQRLALARILLQDAPIVLLDEPTV 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 482 DQDPQFRRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:cd03247 128 GLDPITERQLLSLIFEVLK--DKTLIWITHHLTGIEHMDKILFLENGKIIM 176
|
|
| ABC_OpuCA_Osmoprotection |
cd03295 |
ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ... |
322-530 |
6.20e-17 |
|
ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 80.42 E-value: 6.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03295 1 IEFENVTKRYGGGK----KAVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLIEPTSGEIFIDGEDIREQDPVELRRK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQGPEggepDTALVA---HW------------LERLNMKSKlQFdgARVTNPQLSQGQRKRLALLLA 466
Cdd:cd03295 77 IGYVIQQIGLFPHMTVEE----NIALVPkllKWpkekireradelLALVGLDPA-EF--ADRYPHELSGGQQQRVGVARA 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 467 VAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03295 150 LAADPPLLLMDEPFGALDPITRDQLQEEFKRLQQELGKTIVFVTHDiDEAFRLADRIAIMKNGEI 214
|
|
| ABC_Pro_Gly_Betaine |
cd03294 |
ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ... |
320-530 |
6.77e-17 |
|
ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213261 [Multi-domain] Cd Length: 269 Bit Score: 80.77 E-value: 6.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 QTLELRDVVFHYADAEQQPGFTVG--PLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPD 397
Cdd:cd03294 16 KAFKLLAKGKSKEEILKKTGQTVGvnDVSLDVREGEIFVIMGLSGSGKSTLLRCINRLIEPTSGKVLIDGQDIAAMSRKE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRRL----FSAIFTDFHQFDRLqgpeggepdTAL--VAHWLERLNMKSK--------------LQFDGARVTNpQLSQGQ 457
Cdd:cd03294 96 LRELrrkkISMVFQSFALLPHR---------TVLenVAFGLEVQGVPRAereeraaealelvgLEGWEHKYPD-ELSGGM 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 458 RKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03294 166 QQRVGLARALAVDPDILLMDEAFSALDPLIRREMQDELLRLQAELQKTIVFITHDlDEALRLGDRIAIMKDGRL 239
|
|
| ABC_CysA_sulfate_importer |
cd03296 |
ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ... |
345-539 |
8.35e-17 |
|
ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 80.08 E-value: 8.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRLFSAIFTDFHQFDRLQ-------- 416
Cdd:cd03296 21 VSLDIPSGELVALLGPSGSGKTTLLRLIAGLERPDSGTILFGG--EDATDVPVQERNVGFVFQHYALFRHMTvfdnvafg 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 ---GPEGGEPDTALVAhwlERLNMKSKL-QFDG-ARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRrif 491
Cdd:cd03296 99 lrvKPRSERPPEAEIR---AKVHELLKLvQLDWlADRYPAQLSGGQRQRVALARALAVEPKVLLLDEPFGALDAKVR--- 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 612265813 492 yRELLPALRALGK-----TVFaISHD-DHYFEHADRLLEMRSGHLrELTGSERE 539
Cdd:cd03296 173 -KELRRWLRRLHDelhvtTVF-VTHDqEEALEVADRVVVMNKGRI-EQVGTPDE 223
|
|
| ABC_KpsT_Wzt |
cd03220 |
ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ... |
345-532 |
1.08e-16 |
|
ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.
Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 79.11 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMpdyrrlfsAIFTDFHqfdrlqgPE-GGEP 423
Cdd:cd03220 41 VSFEVPRGERIGLIGRNGAGKSTLLRLLAGIYPPDSGTVTVRG--RVSSLL--------GLGGGFN-------PElTGRE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 424 DTALVAHWLERLN--MKSKLQFD------GARVTNP--QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYR 493
Cdd:cd03220 104 NIYLNGRLLGLSRkeIDEKIDEIiefselGDFIDLPvkTYSSGMKARLAFAIATALEPDILLIDEVLAVGDAAFQEKCQR 183
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 612265813 494 ELLpALRALGKTVFAISHDDHYF-EHADRLLEMRSGHLRE 532
Cdd:cd03220 184 RLR-ELLKQGKTVILVSHDPSSIkRLCDRALVLEKGKIRF 222
|
|
| cbiO |
PRK13637 |
energy-coupling factor transporter ATPase; |
345-539 |
1.56e-16 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 237455 [Multi-domain] Cd Length: 287 Bit Score: 80.09 E-value: 1.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV--AQTAADMPDYRRLFSAIFtdfhQFDRLQ------ 416
Cdd:PRK13637 26 VNIEIEDGEFVGLIGHTGSGKSTLIQHLNGLLKPTSGKIIIDGVdiTDKKVKLSDIRKKVGLVF----QYPEYQlfeeti 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 ------GPEG-GEPDTALVAHWLERLNMkSKLQFDGARVTNP-QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFR 488
Cdd:PRK13637 102 ekdiafGPINlGLSEEEIENRVKRAMNI-VGLDYEDYKDKSPfELSGGQKRRVAIAGVVAMEPKILILDEPTAGLDPKGR 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 489 rifyRELLPALRALGK----TVFAISHD-DHYFEHADRLLEMRSGHLrELTGSERE 539
Cdd:PRK13637 181 ----DEILNKIKELHKeynmTIILVSHSmEDVAKLADRIIVMNKGKC-ELQGTPRE 231
|
|
| AztA |
NF040873 |
zinc ABC transporter ATP-binding protein AztA; |
345-525 |
2.02e-16 |
|
zinc ABC transporter ATP-binding protein AztA;
Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 77.66 E-value: 2.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG-------VAQTAADmpdyrRLFSAIFTDFHQFDRLQ- 416
Cdd:NF040873 11 VDLTIPAGSLTAVVGPNGSGKSTLLKVLAGVLRPTSGTVRRAGgarvayvPQRSEVP-----DSLPLTVRDLVAMGRWAr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 -GPEG--GEPDTALVAHWLERLNMK--SKLQFDgarvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIF 491
Cdd:NF040873 86 rGLWRrlTRDDRAAVDDALERVGLAdlAGRQLG-------ELSGGQRQRALLAQGLAQEADLLLLDEPTTGLDAESRERI 158
|
170 180 190
....*....|....*....|....*....|....
gi 612265813 492 yRELLPALRALGKTVFAISHDDHYFEHADRLLEM 525
Cdd:NF040873 159 -IALLAEEHARGATVVVVTHDLELVRRADPCVLL 191
|
|
| PRK13633 |
PRK13633 |
energy-coupling factor transporter ATPase; |
322-539 |
2.18e-16 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 237453 [Multi-domain] Cd Length: 280 Bit Score: 79.75 E-value: 2.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPG-FTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV----------AQ 390
Cdd:PRK13633 5 IKCKNVSYKYESNEESTEkLALDDVNLEVKKGEFLVILGRNGSGKSTIAKHMNALLIPSEGKVYVDGLdtsdeenlwdIR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 391 TAADM----PDyRRLFSAIFTDFHQFdrlqGPE--GGEPDT--ALVAHWLERLNMksklqFDGARVTNPQLSQGQRKRLA 462
Cdd:PRK13633 85 NKAGMvfqnPD-NQIVATIVEEDVAF----GPEnlGIPPEEirERVDESLKKVGM-----YEYRRHAPHLLSGGQKQRVA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRrifyRELLPALRALGK----TVFAIShddHYFE---HADRLLEMRSGHLReLTG 535
Cdd:PRK13633 155 IAGILAMRPECIIFDEPTAMLDPSGR----REVVNTIKELNKkygiTIILIT---HYMEeavEADRIIVMDSGKVV-MEG 226
|
....
gi 612265813 536 SERE 539
Cdd:PRK13633 227 TPKE 230
|
|
| ABC_PotA_N |
cd03300 |
ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ... |
322-539 |
2.74e-16 |
|
ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 78.43 E-value: 2.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRL 401
Cdd:cd03300 1 IELENVSKFYGG-----FVALDGVSLDIKEGEFFTLLGPSGCGKTTLLRLIAGFETPTSGEILLDG--KDITNLPPHKRP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQGPEG--------GEPDTALVAHWLERLNMkskLQFDGARVTNP-QLSQGQRKRLALLLAVAEQRD 472
Cdd:cd03300 74 VNTVFQNYALFPHLTVFENiafglrlkKLPKAEIKERVAEALDL---VQLEGYANRKPsQLSGGQQQRVAIARALVNEPK 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 473 ILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDhyfEHA----DRLLEMRSGHLRELtGSERE 539
Cdd:cd03300 151 VLLLDEPLGALDLKLRKDMQLELKRLQKELGITFVFVTHDQ---EEAltmsDRIAVMNKGKIQQI-GTPEE 217
|
|
| BtuD |
COG4138 |
ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism]; ... |
342-530 |
2.88e-16 |
|
ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism];
Pssm-ID: 443313 [Multi-domain] Cd Length: 248 Bit Score: 78.73 E-value: 2.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYrPVSGHIVLDGVAQTAADMPDYRRL--------FSAIFTDFHQFD 413
Cdd:COG4138 12 LGPISAQVNAGELIHLIGPNGAGKSTLLARMAGLL-PGQGEILLNGRPLSDWSAAELARHraylsqqqSPPFAMPVFQYL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 414 RLQGPEGGEPDT--ALVAHWLERLNMKSKLqfdgARVTNpQLSQG--QRKRLA-LLLAVAEQRD----ILLLDEWAADQD 484
Cdd:COG4138 91 ALHQPAGASSEAveQLLAQLAEALGLEDKL----SRPLT-QLSGGewQRVRLAaVLLQVWPTINpegqLLLLDEPMNSLD 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 612265813 485 PQFRRIFYReLLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG4138 166 VAQQAALDR-LLRELCQQGITVVMSSHDlNHTLRHADRVWLLKQGKL 211
|
|
| ABC_FtsE |
cd03292 |
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
322-530 |
3.08e-16 |
|
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages
Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 77.83 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeqqPGFTVGPLNLTLR--RGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQT---AADMP 396
Cdd:cd03292 1 IEFINVTKTY------PNGTAALDGINISisAGEFVFLVGPSGAGKSTLLKLIYKEELPTSGTIRVNGQDVSdlrGRAIP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 397 DYRRLFSAIFTDFHQFDRLQGPEG--------GEPDTAL---VAHWLERLNMKSKlqfdgARVTNPQLSQGQRKRLALLL 465
Cdd:cd03292 75 YLRRKIGVVFQDFRLLPDRNVYENvafalevtGVPPREIrkrVPAALELVGLSHK-----HRALPAELSGGEQQRVAIAR 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 466 AVAEQRDILLLDEWAADQDPQF-RRIFyrELLPALRALGKTVFAISHDDHYFE-HADRLLEMRSGHL 530
Cdd:cd03292 150 AIVNSPTILIADEPTGNLDPDTtWEIM--NLLKKINKAGTTVVVATHAKELVDtTRHRVIALERGKL 214
|
|
| ABC_subfamily_A |
cd03263 |
ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ... |
345-531 |
3.30e-16 |
|
ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.
Pssm-ID: 213230 [Multi-domain] Cd Length: 220 Bit Score: 77.55 E-value: 3.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvAQTAADMPDYRRL------FSAIFTDF------HQF 412
Cdd:cd03263 21 LSLNVYKGEIFGLLGHNGAGKTTTLKMLTGELRPTSGTAYING-YSIRTDRKAARQSlgycpqFDALFDELtvrehlRFY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRLQGPEGGEPDtALVAHWLERLNMKSKLQfdgARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFY 492
Cdd:cd03263 100 ARLKGLPKSEIK-EEVELLLRVLGLTDKAN---KRART--LSGGMKRKLSLAIALIGGPSVLLLDEPTSGLDPASRRAIW 173
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 612265813 493 ReLLPALRAlGKTVFAISHDDHYFEH-ADRLLEMRSGHLR 531
Cdd:cd03263 174 D-LILEVRK-GRSIILTTHSMDEAEAlCDRIAIMSDGKLR 211
|
|
| cbiO |
PRK13640 |
energy-coupling factor transporter ATPase; |
322-530 |
5.88e-16 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 78.30 E-value: 5.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVS---GHIVLDGVAQTAADMPDY 398
Cdd:PRK13640 6 VEFKHVSFTYPDSKKP---ALNDISFSIPRGSWTALIGHNGSGKSTISKLINGLLLPDDnpnSKITVDGITLTAKTVWDI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAIFtdfhqfdrlQGPEG---GEPDTALVAHWLE-----RLNMKSKLQFDGARV-------TNPQ-LSQGQRKRLA 462
Cdd:PRK13640 83 REKVGIVF---------QNPDNqfvGATVGDDVAFGLEnravpRPEMIKIVRDVLADVgmldyidSEPAnLSGGQKQRVA 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRrifyRELLPALRALGK----TVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:PRK13640 154 IAGILAVEPKIIILDESTSMLDPAGK----EQILKLIRKLKKknnlTVISITHDIDEANMADQVLVLDDGKL 221
|
|
| cbiO |
PRK13641 |
energy-coupling factor transporter ATPase; |
345-530 |
7.87e-16 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 77.95 E-value: 7.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG---VAQTAA-DMPDYRRLFSAIFtdfhQFDRLQ---- 416
Cdd:PRK13641 26 ISFELEEGSFVALVGHTGSGKSTLMQHFNALLKPSSGTITIAGyhiTPETGNkNLKKLRKKVSLVF----QFPEAQlfen 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 --------GPE--GGEPDTALVA--HWLERLNMK----SKLQFDgarvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWA 480
Cdd:PRK13641 102 tvlkdvefGPKnfGFSEDEAKEKalKWLKKVGLSedliSKSPFE--------LSGGQMRRVAIAGVMAYEPEILCLDEPA 173
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 481 ADQDPQFRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK13641 174 AGLDPEGRKEMM-QLFKDYQKAGHTVILVTHNmDDVAEYADDVLVLEHGKL 223
|
|
| ArpD |
COG4618 |
ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ... |
278-531 |
1.18e-15 |
|
ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443660 [Multi-domain] Cd Length: 563 Bit Score: 79.79 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 278 PLLQAVGAFPTLVGAEVAFNKLKALrLAEYQSGF-----PAAVGRswqtLELRDVVFHYADAEQQpgfTVGPLNLTLRRG 352
Cdd:COG4618 287 PIEQAIGGWKQFVSARQAYRRLNEL-LAAVPAEPermplPRPKGR----LSVENLTVVPPGSKRP---ILRGVSFSLEPG 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 353 ELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaqtaadmpdyrrlfsaiftDFHQFDRLQ-GP------------E 419
Cdd:COG4618 359 EVLGVIGPSGSGKSTLARLLVGVWPPTAGSVRLDGA-------------------DLSQWDREElGRhigylpqdvelfD 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 G---------GEPDTALV--------AH-WLERLNM--KSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEW 479
Cdd:COG4618 420 GtiaeniarfGDADPEKVvaaaklagVHeMILRLPDgyDTRIGEGGAR-----LSGGQRQRIGLARALYGDPRLVVLDEP 494
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 612265813 480 AADQDPQFRRIFYRELLpALRALGKTVFAISHDDHYFEHADRLLEMRSGHLR 531
Cdd:COG4618 495 NSNLDDEGEAALAAAIR-ALKARGATVVVITHRPSLLAAVDKLLVLRDGRVQ 545
|
|
| YbbA |
COG4181 |
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ... |
322-539 |
1.25e-15 |
|
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 76.32 E-value: 1.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgftvGPL------NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADm 395
Cdd:COG4181 9 IELRGLTKTVGTGA-------GELtilkgiSLEVEAGESVAIVGASGSGKSTLLGLLAGLDRPTSGTVRLAGQDLFALD- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 PDYRRLFSA-----IFTDFHQFDRLQGPE--------GGEPD-TALVAHWLERLNMksklqfdGARVTN--PQLSQGQRK 459
Cdd:COG4181 81 EDARARLRArhvgfVFQSFQLLPTLTALEnvmlplelAGRRDaRARARALLERVGL-------GHRLDHypAQLSGGEQQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 460 RLALLLAVAEQRDILLLDEWAADQDPQF-RRIFyrELLPAL-RALGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSE 537
Cdd:COG4181 154 RVALARAFATEPAILFADEPTGNLDAATgEQII--DLLFELnRERGTTLVLVTHDPALAARCDRVLRLRAGRLVEDTAAT 231
|
..
gi 612265813 538 RE 539
Cdd:COG4181 232 AA 233
|
|
| ABC_ThiQ_thiamine_transporter |
cd03298 |
ATP-binding cassette domain of the thiamine transport system; Part of the ... |
322-522 |
1.61e-15 |
|
ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 75.61 E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadMPDYRRL 401
Cdd:cd03298 1 VRLDKIRFSYGEQPMH-------FDLTFAQGEITAIVGPSGSGKSTLLNLIAGFETPQSGRVLINGVDVTA--APPADRP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLQGPE----GGEPDTALVAHwlERLNMKSKLQ---FDGARVTNP-QLSQGQRKRLALLLAVAEQRDI 473
Cdd:cd03298 72 VSMLFQENNLFAHLTVEQnvglGLSPGLKLTAE--DRQAIEVALArvgLAGLEKRLPgELSGGERQRVALARVLVRDKPV 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 612265813 474 LLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAIShddHYFEHADRL 522
Cdd:cd03298 150 LLLDEPFAALDPALRAEMLDLVLDLHAETKMTVLMVT---HQPEDAKRL 195
|
|
| ABC_drug_resistance_like |
cd03264 |
ABC-type multidrug transport system, ATPase component; The biological function of this family ... |
322-531 |
1.70e-15 |
|
ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 75.31 E-value: 1.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpGFTVGPLNLTLRRGELVfLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03264 1 LQLENLTKRYGK-----KRALDGVSLTLGPGMYG-LLGPNGAGKTTLMRILATLTPPSSGTIRIDGQDVLKQPQKLRRRI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 --------FSAIFTDFHQFD---RLQGPEGGEPDtALVAHWLERLNMkskLQFDGARVTnpQLSQGQRKRLALLLAVAEQ 470
Cdd:cd03264 75 gylpqefgVYPNFTVREFLDyiaWLKGIPSKEVK-ARVDEVLELVNL---GDRAKKKIG--SLSGGMRRRVGIAQALVGD 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 471 RDILLLDEWAADQDPQfRRIFYRELLPALRAlGKTVFAISHD-DHYFEHADRLLEMRSGHLR 531
Cdd:cd03264 149 PSILIVDEPTAGLDPE-ERIRFRNLLSELGE-DRIVILSTHIvEDVESLCNQVAVLNKGKLV 208
|
|
| potA |
PRK09452 |
spermidine/putrescine ABC transporter ATP-binding protein PotA; |
322-539 |
3.06e-15 |
|
spermidine/putrescine ABC transporter ATP-binding protein PotA;
Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 77.29 E-value: 3.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRR- 400
Cdd:PRK09452 15 VELRGISKSFDGKE-----VISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFETPDSGRIMLDG--QDITHVPAENRh 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 ---LFS--AIFTDFHQFD------RLQGPEGGEPDTALvahwLERLNMKSKLQFDGARVTnpQLSQGQRKRLALLLAVAE 469
Cdd:PRK09452 88 vntVFQsyALFPHMTVFEnvafglRMQKTPAAEITPRV----MEALRMVQLEEFAQRKPH--QLSGGQQQRVAIARAVVN 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 470 QRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDhyfEHA----DRLLEMRSGHLrELTGSERE 539
Cdd:PRK09452 162 KPKVLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQ---EEAltmsDRIVVMRDGRI-EQDGTPRE 231
|
|
| cbiO |
PRK13636 |
cobalt transporter ATP-binding subunit; Provisional |
322-528 |
3.98e-15 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 184196 [Multi-domain] Cd Length: 283 Bit Score: 76.04 E-value: 3.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYR 399
Cdd:PRK13636 6 LKVEELNYNYSDGTH----ALKGININIKKGEVTAILGGNGAGKSTLFQNLNGILKPSSGRILFDGkpIDYSRKGLMKLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTD-FHQF-------DRLQGPEG-GEPDTAL---VAHWLERL---NMKSKlqfdgarvTNPQLSQGQRKRLALL 464
Cdd:PRK13636 82 ESVGMVFQDpDNQLfsasvyqDVSFGAVNlKLPEDEVrkrVDNALKRTgieHLKDK--------PTHCLSFGQKKRVAIA 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 465 LAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:PRK13636 154 GVLVMEPKVLVLDEPTAGLDPMGVSEIMKLLVEMQKELGLTIIIATHDiDIVPLYCDNVFVMKEG 218
|
|
| 3a01208 |
TIGR00958 |
Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] |
322-533 |
6.97e-15 |
|
Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]
Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 77.84 E-value: 6.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTvgPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR- 400
Cdd:TIGR00958 479 IEFQDVSFSYPNRPDVPVLK--GLTFTLHPGEVVALVGPSGSGKSTVAALLQNLYQPTGGQVLLDGVPLVQYDHHYLHRq 556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 ---------LFSAIFTDFHQFDRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQR 471
Cdd:TIGR00958 557 valvgqepvLFSGSVRENIAYGLTDTPDEEIMAAAKAANAHDFIMEFPNGYDTEVGEKGSQLSGGQKQRIAIARALVRKP 636
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 472 DILLLDEWAADQDPQFRRIFYRellpALRALGKTVFAISHDDHYFEHADRLLEMRSGHLREL 533
Cdd:TIGR00958 637 RVLILDEATSALDAECEQLLQE----SRSRASRTVLLIAHRLSTVERADQILVLKKGSVVEM 694
|
|
| PRK09984 |
PRK09984 |
phosphonate ABC transporter ATP-binding protein; |
345-530 |
7.24e-15 |
|
phosphonate ABC transporter ATP-binding protein;
Pssm-ID: 182182 [Multi-domain] Cd Length: 262 Bit Score: 74.66 E-value: 7.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLY---RPVSGHIVLDG-----VAQTAADMPDYRRLFSAIFTDFHQFDRLQ 416
Cdd:PRK09984 23 VDLNIHHGEMVALLGPSGSGKSTLLRHLSGLItgdKSAGSHIELLGrtvqrEGRLARDIRKSRANTGYIFQQFNLVNRLS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 -------GPEGGEPDTALVAHWLERLNMKSKLQ---------FDGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWA 480
Cdd:PRK09984 103 vlenvliGALGSTPFWRTCFSWFTREQKQRALQaltrvgmvhFAHQRVST--LSGGQQQRVAIARALMQQAKVILADEPI 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 481 ADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK09984 181 ASLDPESARIVMDTLRDINQNDGITVVVTLHQvDYALRYCERIVALRQGHV 231
|
|
| ABC_ModC_molybdenum_transporter |
cd03297 |
ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type ... |
337-531 |
1.14e-14 |
|
ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213264 [Multi-domain] Cd Length: 214 Bit Score: 73.10 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 337 QPGFTvgpLNLTLR-RGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV----AQTAADMPDYRRLFSAIF---TD 408
Cdd:cd03297 10 LPDFT---LKIDFDlNEEVTGIFGASGAGKSTLLRCIAGLEKPDGGTIVLNGTvlfdSRKKINLPPQQRKIGLVFqqyAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 409 FHQFDRLQGPEGG------EPDTALVAHWLERLNMkSKLQFDGARvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAAD 482
Cdd:cd03297 87 FPHLNVRENLAFGlkrkrnREDRISVDELLDLLGL-DHLLNRYPA----QLSGGEKQRVALARALAAQPELLLLDEPFSA 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 483 QDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLR 531
Cdd:cd03297 162 LDRALRLQLLPELKQIKKNLNIPVIFVTHDlSEAEYLADRIVVMEDGRLQ 211
|
|
| ABC_putative_ATPase |
cd03269 |
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ... |
345-528 |
1.46e-14 |
|
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 72.70 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD------MPDYRRLF-------SAIFtdfhq 411
Cdd:cd03269 19 ISFSVEKGEIFGLLGPNGAGKTTTIRMILGIILPDSGEVLFDGKPLDIAArnrigyLPEERGLYpkmkvidQLVY----- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 412 FDRLQG--PEGGEPDtalVAHWLERLNMKSKLQfdgARVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRR 489
Cdd:cd03269 94 LAQLKGlkKEEARRR---IDEWLERLELSEYAN---KRVE--ELSKGNQQKVQFIAAVIHDPELLILDEPFSGLDPVNVE 165
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 612265813 490 IFYRELLpALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:cd03269 166 LLKDVIR-ELARAGKTVILSTHQmELVEELCDRVLLLNKG 204
|
|
| ABC_HisP_GlnQ |
cd03262 |
ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ... |
322-530 |
1.57e-14 |
|
ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.
Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 72.56 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYR 399
Cdd:cd03262 1 IEIKNLHKSFGDFHVLKG-----IDLTVKKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTIIIDGlkLTDDKKNINELR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDFHQFDRLQGPEG---------GEPDTALVAH---WLERLNMKSKlqfdgARVTNPQLSQGQRKRLALLLAV 467
Cdd:cd03262 76 QKVGMVFQQFNLFPHLTVLENitlapikvkGMSKAEAEERaleLLEKVGLADK-----ADAYPAQLSGGQQQRVAIARAL 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 468 AEQRDILLLDEWAADQDPQFRrifyRELLPALRAL---GKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03262 151 AMNPKVMLFDEPTSALDPELV----GEVLDVMKDLaeeGMTMVVVTHEmGFAREVADRVIFMDDGRI 213
|
|
| PhnK |
COG1101 |
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ... |
345-486 |
2.33e-14 |
|
ABC-type uncharacterized transport system, ATPase component [General function prediction only];
Pssm-ID: 440718 [Multi-domain] Cd Length: 264 Bit Score: 73.20 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadMPDYRR--LFSAIFtdfhqfdrlQGPEGG- 421
Cdd:COG1101 25 LNLTIEEGDFVTVIGSNGAGKSTLLNAIAGSLPPDSGSILIDGKDVTK--LPEYKRakYIGRVF---------QDPMMGt 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 422 ---------------------------EPDTALVAHWLERLNM--KSKLqfdGARVTNpqLSQGQRKRLALLLAVAEQRD 472
Cdd:COG1101 94 apsmtieenlalayrrgkrrglrrgltKKRRELFRELLATLGLglENRL---DTKVGL--LSGGQRQALSLLMATLTKPK 168
|
170
....*....|....
gi 612265813 473 ILLLDEWAADQDPQ 486
Cdd:COG1101 169 LLLLDEHTAALDPK 182
|
|
| ABCC_Hemolysin |
cd03252 |
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ... |
345-545 |
2.93e-14 |
|
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy.
Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 72.52 E-value: 2.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFDRLQGPEGGEPD 424
Cdd:cd03252 21 ISLRIKPGEVVGIVGRSGSGKSTLTKLIQRFYVPENGRVLVDGHDLALADPAWLRRQVGVVLQENVLFNRSIRDNIALAD 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 425 TALVahwLERLNMKSKL---------------QFDGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRR 489
Cdd:cd03252 101 PGMS---MERVIEAAKLagahdfiselpegydTIVGEQGAG--LSGGQRQRIAIARALIHNPRILIFDEATSALDYESEH 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 490 IFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRElTGSEREHASRDS 545
Cdd:cd03252 176 AIMRNMHDICA--GRTVIIIAHRLSTVKNADRIIVMEKGRIVE-QGSHDELLAENG 228
|
|
| PRK11160 |
PRK11160 |
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
322-532 |
3.27e-14 |
|
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed
Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 75.25 E-value: 3.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:PRK11160 339 LTLNNVSFTYPDQPQP---VLKGLSLQIKAGEKVALLGRTGCGKSTLLQLLTRAWDPQQGEILLNGQPIADYSEAALRQA 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQF-----DRLQGPEGGEPDTALVAhWLERLNMKSKLQFD---------GARvtnpQLSQGQRKRLALLLAV 467
Cdd:PRK11160 416 ISVVSQRVHLFsatlrDNLLLAAPNASDEALIE-VLQQVGLEKLLEDDkglnawlgeGGR----QLSGGEQRRLGIARAL 490
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 468 AEQRDILLLDEWAADQDPQFRrifyRELLPALR--ALGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PRK11160 491 LHDAPLLLLDEPTEGLDAETE----RQILELLAehAQNKTVLMITHRLTGLEQFDRICVMDNGQIIE 553
|
|
| PRK03695 |
PRK03695 |
vitamin B12-transporter ATPase; Provisional |
343-530 |
4.06e-14 |
|
vitamin B12-transporter ATPase; Provisional
Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 72.27 E-value: 4.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 343 GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYrPVSGHIVLDGVA---QTAADMPDYRRLFS-----AIFTDFHQFDR 414
Cdd:PRK03695 13 GPLSAEVRAGEILHLVGPNGAGKSTLLARMAGLL-PGSGSIQFAGQPleaWSAAELARHRAYLSqqqtpPFAMPVFQYLT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 415 LQGPEGGEPD--TALVAHWLERLNMKSKLqfdgARVTNpQLSQG--QRKRLAlllAVAEQ--RDI------LLLDEWAAD 482
Cdd:PRK03695 92 LHQPDKTRTEavASALNEVAEALGLDDKL----GRSVN-QLSGGewQRVRLA---AVVLQvwPDInpagqlLLLDEPMNS 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 612265813 483 QDPQFRRIFYReLLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK03695 164 LDVAQQAALDR-LLSELCQQGIAVVMSSHDlNHTLRHADRVWLLKQGKL 211
|
|
| ABC_ModC_like |
cd03299 |
ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely ... |
340-530 |
5.59e-14 |
|
ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213266 [Multi-domain] Cd Length: 235 Bit Score: 71.60 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 340 FTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaaDMPDYRRLFSAIFTDFHQFDRLQGPE 419
Cdd:cd03299 13 FKLKNVSLEVERGDYFVILGPTGSGKSVLLETIAGFIKPDSGKILLNGKDIT--NLPPEKRDISYVPQNYALFPHMTVYK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 GgepdtalVAHWLE-RLNMKSKLQfdgARVTN--------------PQ-LSQGQRKRLALLLAVAEQRDILLLDEWAADQ 483
Cdd:cd03299 91 N-------IAYGLKkRKVDKKEIE---RKVLEiaemlgidhllnrkPEtLSGGEQQRVAIARALVVNPKILLLDEPFSAL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 484 DPQFRRIFYRELLPALRALGKTVFAISHDdhyFEHA----DRLLEMRSGHL 530
Cdd:cd03299 161 DVRTKEKLREELKKIRKEFGVTVLHVTHD---FEEAwalaDKVAIMLNGKL 208
|
|
| ABC_MetN_methionine_transporter |
cd03258 |
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ... |
345-539 |
6.42e-14 |
|
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 71.46 E-value: 6.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTA---ADMPDYRRLFSAIFTDFHQFDRLQGPE-- 419
Cdd:cd03258 24 VSLSVPKGEIFGIIGRSGAGKSTLIRCINGLERPTSGSVLVDGTDLTLlsgKELRKARRRIGMIFQHFNLLSSRTVFEnv 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 ------GGEPDTAL---VAHWLERLNMKSKLQFDGArvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRI 490
Cdd:cd03258 104 alpleiAGVPKAEIeerVLELLELVGLEDKADAYPA-----QLSGGQKQRVGIARALANNPKVLLCDEATSALDPETTQS 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 491 FYRELLPALRALGKTVFAISHDDHYF-EHADRLLEMRSGHLRElTGSERE 539
Cdd:cd03258 179 ILALLRDINRELGLTIVLITHEMEVVkRICDRVAVMEKGEVVE-EGTVEE 227
|
|
| PRK13536 |
PRK13536 |
nodulation factor ABC transporter ATP-binding protein NodI; |
342-522 |
9.37e-14 |
|
nodulation factor ABC transporter ATP-binding protein NodI;
Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 72.56 E-value: 9.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAqtaadMPDYRRLFSAIFTDFHQFDRLQgPEGG 421
Cdd:PRK13536 57 VNGLSFTVASGECFGLLGPNGAGKSTIARMILGMTSPDAGKITVLGVP-----VPARARLARARIGVVPQFDNLD-LEFT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 422 EPDTALVAHWLERLN-------MKSKLQFdgARVTN------PQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFR 488
Cdd:PRK13536 131 VRENLLVFGRYFGMStreieavIPSLLEF--ARLESkadarvSDLSGGMKRRLTLARALINDPQLLILDEPTTGLDPHAR 208
|
170 180 190
....*....|....*....|....*....|....
gi 612265813 489 RIFYrELLPALRALGKTVFAIShddHYFEHADRL 522
Cdd:PRK13536 209 HLIW-ERLRSLLARGKTILLTT---HFMEEAERL 238
|
|
| ABC_NatA_sodium_exporter |
cd03266 |
ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ... |
345-531 |
1.39e-13 |
|
ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.
Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 70.09 E-value: 1.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAqTAADMPDYRRLFSAIFTDFHQFDRLQGPE----- 419
Cdd:cd03266 24 VSFTVKPGEVTGLLGPNGAGKTTTLRMLAGLLEPDAGFATVDGFD-VVKEPAEARRRLGFVSDSTGLYDRLTAREnleyf 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 ----GGEPD--TALVAHWLERLNMKSKLQFDGArvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFyR 493
Cdd:cd03266 103 aglyGLKGDelTARLEELADRLGMEELLDRRVG-----GFSTGMRQKVAIARALVHDPPVLLLDEPTTGLDVMATRAL-R 176
|
170 180 190
....*....|....*....|....*....|....*....
gi 612265813 494 ELLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHLR 531
Cdd:cd03266 177 EFIRQLRALGKCILFSTHIMQEVERlCDRVVVLHRGRVV 215
|
|
| type_I_sec_PrtD |
TIGR01842 |
type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in ... |
278-530 |
1.54e-13 |
|
type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 200134 [Multi-domain] Cd Length: 544 Bit Score: 73.15 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 278 PLLQAVGAFPTLVGAEVAFNKLKALrLAEYQSGFPA-AVGRSWQTLELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVF 356
Cdd:TIGR01842 273 PIDGAIGGWKQFSGARQAYKRLNEL-LANYPSRDPAmPLPEPEGHLSVENVTIVPPGGKKP---TLRGISFSLQAGEALA 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 357 LIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD----------MPDYRRLFS-AIFTDFHQFDRLQGPEG-GEPD 424
Cdd:TIGR01842 349 IIGPSGSGKSTLARLIVGIWPPTSGSVRLDGADLKQWDretfgkhigyLPQDVELFPgTVAENIARFGENADPEKiIEAA 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 425 TALVAHWL-ERLNM--KSKLQFDGArvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLpALRA 501
Cdd:TIGR01842 429 KLAGVHELiLRLPDgyDTVIGPGGA-----TLSGGQRQRIALARALYGDPKLVVLDEPNSNLDEEGEQALANAIK-ALKA 502
|
250 260
....*....|....*....|....*....
gi 612265813 502 LGKTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:TIGR01842 503 RGITVVVITHRPSLLGCVDKILVLQDGRI 531
|
|
| PRK11176 |
PRK11176 |
lipid A ABC transporter ATP-binding protein/permease MsbA; |
322-532 |
1.81e-13 |
|
lipid A ABC transporter ATP-binding protein/permease MsbA;
Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 73.13 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaqtaaDMPDY--- 398
Cdd:PRK11176 342 IEFRNVTFTYPGKEVP---ALRNINFKIPAGKTVALVGRSGSGKSTIANLLTRFYDIDEGEILLDGH-----DLRDYtla 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 --RRLFSAIFTDFHQFDrlqgpeggepDT---------------------ALVAHWLERLNmKSKLQFDGARVTN-PQLS 454
Cdd:PRK11176 414 slRNQVALVSQNVHLFN----------DTianniayarteqysreqieeaARMAYAMDFIN-KMDNGLDTVIGENgVLLS 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 455 QGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRellpALRALGK--TVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PRK11176 483 GGQRQRIAIARALLRDSPILILDEATSALDTESERAIQA----ALDELQKnrTSLVIAHRLSTIEKADEILVVEDGEIVE 558
|
|
| TagH |
COG1134 |
ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ... |
345-532 |
1.94e-13 |
|
ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism];
Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 70.11 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG-VA------------QTAAD----------MP--DYR 399
Cdd:COG1134 45 VSFEVERGESVGIIGRNGAGKSTLLKLIAGILEPTSGRVEVNGrVSallelgagfhpeLTGREniylngrllgLSrkEID 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAI--FTDFHQFdrlqgpeggepdtalvahwlerLNMKSKlqfdgarvtnpQLSQGQRKRLALLLAVAEQRDILLLD 477
Cdd:COG1134 125 EKFDEIveFAELGDF----------------------IDQPVK-----------TYSSGMRARLAFAVATAVDPDILLVD 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 478 EWAADQDPQFRRIFYRELLpALRALGKTVFAISHDDHYF-EHADRLLEMRSGHLRE 532
Cdd:COG1134 172 EVLAVGDAAFQKKCLARIR-ELRESGRTVIFVSHSMGAVrRLCDRAIWLEKGRLVM 226
|
|
| CysA |
COG1118 |
ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and ... |
321-530 |
2.24e-13 |
|
ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism];
Pssm-ID: 440735 [Multi-domain] Cd Length: 348 Bit Score: 71.33 E-value: 2.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFHYADaeqqpgFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG-VAQTAADMPDy 398
Cdd:COG1118 2 SIEVRNISKRFGS------FTLlDDVSLEIASGELVALLGPSGSGKTTLLRIIAGLETPDSGRIVLNGrDLFTNLPPRE- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RR---LFS--AIFTDFHQFDRLQ-GPEGGEPDTA----LVAHWLERLNMKsklQFDGARVTnpQLSQGQRKRLALLLAVA 468
Cdd:COG1118 75 RRvgfVFQhyALFPHMTVAENIAfGLRVRPPSKAeiraRVEELLELVQLE---GLADRYPS--QLSGGQRQRVALARALA 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 469 EQRDILLLDE-WAAdQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG1118 150 VEPEVLLLDEpFGA-LDAKVRKELRRWLRRLHDELGGTTVFVTHDqEEALELADRVVVMNQGRI 212
|
|
| livG |
PRK11300 |
leucine/isoleucine/valine transporter ATP-binding subunit; Provisional |
342-512 |
2.37e-13 |
|
leucine/isoleucine/valine transporter ATP-binding subunit; Provisional
Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 70.02 E-value: 2.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYR-------------RLF------ 402
Cdd:PRK11300 21 VNNVNLEVREQEIVSLIGPNGAGKTTVFNCLTGFYKPTGGTILLRG--QHIEGLPGHQiarmgvvrtfqhvRLFremtvi 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 ------------SAIFTDFHQFDRLQGPEGGEPDTAlvAHWLERLNMKSklqfdgarVTNPQ---LSQGQRKRLALLLAV 467
Cdd:PRK11300 99 enllvaqhqqlkTGLFSGLLKTPAFRRAESEALDRA--ATWLERVGLLE--------HANRQagnLAYGQQRRLEIARCM 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 612265813 468 AEQRDILLLDEWAADQDPQfRRIFYRELLPALR-ALGKTVFAISHD 512
Cdd:PRK11300 169 VTQPEILMLDEPAAGLNPK-ETKELDELIAELRnEHNVTVLLIEHD 213
|
|
| ABCC_ATM1_transporter |
cd03253 |
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ... |
322-539 |
2.54e-13 |
|
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 69.57 E-value: 2.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeqQPGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR 400
Cdd:cd03253 1 IEFENVTFAY-----DPGRPVlKDVSFTIPAGKKVAIVGPSGSGKSTILRLLFRFYDVSSGSILIDGQDIREVTLDSLRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 ----------LFSAIFTDFHQFDRLQGPEGGEPDTALVAHWLERLnMKSKLQFD---GARVTnpQLSQGQRKRLALLLAV 467
Cdd:cd03253 76 aigvvpqdtvLFNDTIGYNIRYGRPDATDEEVIEAAKAAQIHDKI-MRFPDGYDtivGERGL--KLSGGEKQRVAIARAI 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 468 AEQRDILLLDEWAADQDPQFRrifyRELLPALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRElTGSERE 539
Cdd:cd03253 153 LKNPPILLLDEATSALDTHTE----REIQAALRDVskGRTTIVIAHRLSTIVNADKIIVLKDGRIVE-RGTHEE 221
|
|
| ABC_BcrA_bacitracin_resist |
cd03268 |
ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily ... |
345-532 |
2.99e-13 |
|
ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.
Pssm-ID: 213235 [Multi-domain] Cd Length: 208 Bit Score: 68.78 E-value: 2.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaADMPDYRRLFSAI--------FTDFHQFdRLQ 416
Cdd:cd03268 19 ISLHVKKGEIYGFLGPNGAGKTTTMKIILGLIKPDSGEITFDGKSYQ-KNIEALRRIGALIeapgfypnLTARENL-RLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 GPEGGEPDTAlVAHWLERLNMKsklqfDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ-FRRIfyREL 495
Cdd:cd03268 97 ARLLGIRKKR-IDEVLDVVGLK-----DSAKKKVKGFSLGMKQRLGIALALLGNPDLLILDEPTNGLDPDgIKEL--REL 168
|
170 180 190
....*....|....*....|....*....|....*...
gi 612265813 496 LPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHLRE 532
Cdd:cd03268 169 ILSLRDQGITVLISSHLLSEIQKvADRIGIINKGKLIE 206
|
|
| ABC_FeS_Assembly |
cd03217 |
ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ... |
345-530 |
3.90e-13 |
|
ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet.
Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 68.32 E-value: 3.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGL--YRPVSGHIVLDGvaQTAADMPDYRRLFSAIFTDFhqfdrlQGPEggE 422
Cdd:cd03217 19 VNLTIKKGEVHALMGPNGSGKSTLAKTIMGHpkYEVTEGEILFKG--EDITDLPPEERARLGIFLAF------QYPP--E 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 423 PDTALVAHWLERLNMKsklqfdgarvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAA--DQDpQFRRIFyrELLPALR 500
Cdd:cd03217 89 IPGVKNADFLRYVNEG--------------FSGGEKKRNEILQLLLLEPDLAILDEPDSglDID-ALRLVA--EVINKLR 151
|
170 180 190
....*....|....*....|....*....|..
gi 612265813 501 ALGKTVFAISHDDHYFEH--ADRLLEMRSGHL 530
Cdd:cd03217 152 EEGKSVLIITHYQRLLDYikPDRVHVLYDGRI 183
|
|
| ABCC_TAP |
cd03248 |
ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ... |
322-530 |
4.11e-13 |
|
ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes.
Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 69.04 E-value: 4.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03248 12 VKFQNVTFAYPTRPDTL--VLQDVSFTLHPGEVTALVGPSGSGKSTVVALLENFYQPQGGQVLLDGKPISQYEHKYLHSK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDR---------LQGPEGGEPDTALVAHWLERLNMKSKLQFD-GARVTNPQLSQGQRKRLALLLAVAEQR 471
Cdd:cd03248 90 VSLVGQEPVLFARslqdniaygLQSCSFECVKEAAQKAHAHSFISELASGYDtEVGEKGSQLSGGQKQRVAIARALIRNP 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 472 DILLLDEWAADQDPQFRRIFYRELLPALRAlgKTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:cd03248 170 QVLILDEATSALDAESEQQVQQALYDWPER--RTVLVIAHRLSTVERADQILVLDGGRI 226
|
|
| glnQ |
PRK09493 |
glutamine ABC transporter ATP-binding protein GlnQ; |
322-532 |
5.04e-13 |
|
glutamine ABC transporter ATP-binding protein GlnQ;
Pssm-ID: 181906 [Multi-domain] Cd Length: 240 Bit Score: 68.97 E-value: 5.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYR 399
Cdd:PRK09493 2 IEFKNVSKHFGPTQ-----VLHNIDLNIDQGEVVVIIGPSGSGKSTLLRCINKLEEITSGDLIVDGlkVNDPKVDERLIR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDFHQFDRLqgpeggepdTAL--VAHWLERLNMKSKLQFD------------GARVTN--PQLSQGQRKRLAL 463
Cdd:PRK09493 77 QEAGMVFQQFYLFPHL---------TALenVMFGPLRVRGASKEEAEkqarellakvglAERAHHypSELSGGQQQRVAI 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612265813 464 LLAVAEQRDILLLDEWAADQDPQFRrifyRELLPALRAL---GKTVFAISHDDHYFEH-ADRLLEMRSGHLRE 532
Cdd:PRK09493 148 ARALAVKPKLMLFDEPTSALDPELR----HEVLKVMQDLaeeGMTMVIVTHEIGFAEKvASRLIFIDKGRIAE 216
|
|
| ABC_MTABC3_MDL1_MDL2 |
cd03249 |
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ... |
323-539 |
5.43e-13 |
|
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.
Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 68.72 E-value: 5.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEQQPGFTvgPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:cd03249 2 EFKNVSFRYPSRPDVPILK--GLSLTIPPGKTVALVGSSGCGKSTVVSLLERFYDPTSGEILLDGVDIRDLNLRWLRSQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFTDFHQFD-------RLQGPEGGEPDTALVAHWLERLNMKSKL--QFD---GARVTnpQLSQGQRKRLALLLAVAEQ 470
Cdd:cd03249 80 GLVSQEPVLFDgtiaeniRYGKPDATDEEVEEAAKKANIHDFIMSLpdGYDtlvGERGS--QLSGGQKQRIAIARALLRN 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 471 RDILLLDEWAADQDPQFRRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRElTGSERE 539
Cdd:cd03249 158 PKILLLDEATSALDAESEKLVQEALDRAMK--GRTTIVIAHRLSTIRNADLIAVLQNGQVVE-QGTHDE 223
|
|
| btuD |
PRK09536 |
corrinoid ABC transporter ATPase; Reviewed |
321-512 |
5.78e-13 |
|
corrinoid ABC transporter ATPase; Reviewed
Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 70.64 E-value: 5.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR 400
Cdd:PRK09536 3 MIDVSDLSVEFGDTT-----VLDGVDLSVREGSLVGLVGPNGAGKTTLLRAINGTLTPTAGTVLVAGDDVEALSARAASR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFTD----FhQFDRLQGPEGG------------EPDTALVAHWLERLNMKsklQFDGARVTNpqLSQGQRKRLALL 464
Cdd:PRK09536 78 RVASVPQDtslsF-EFDVRQVVEMGrtphrsrfdtwtETDRAAVERAMERTGVA---QFADRPVTS--LSGGERQRVLLA 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 612265813 465 LAVAEQRDILLLDEWAADQDPQfRRIFYRELLPALRALGKTVFAISHD 512
Cdd:PRK09536 152 RALAQATPVLLLDEPTASLDIN-HQVRTLELVRRLVDDGKTAVAAIHD 198
|
|
| cbiO |
PRK13648 |
cobalt transporter ATP-binding subunit; Provisional |
322-528 |
6.51e-13 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 69.01 E-value: 6.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHY-ADAeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR 400
Cdd:PRK13648 8 IVFKNVSFQYqSDA----SFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 LFSAIFTD--------FHQFDRLQGPEGG----EPDTALVAHWLERLNMKSKLQFDgarvtnPQ-LSQGQRKRLALLLAV 467
Cdd:PRK13648 84 HIGIVFQNpdnqfvgsIVKYDVAFGLENHavpyDEMHRRVSEALKQVDMLERADYE------PNaLSGGQKQRVAIAGVL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 468 AEQRDILLLDEWAADQDPQFRrifyRELLPALRALGK----TVFAISHDDHYFEHADRLLEMRSG 528
Cdd:PRK13648 158 ALNPSVIILDEATSMLDPDAR----QNLLDLVRKVKSehniTIISITHDLSEAMEADHVIVMNKG 218
|
|
| MK0520 |
COG2401 |
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
345-513 |
7.45e-13 |
|
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];
Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 68.06 E-value: 7.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLY--RPVSGHIVLDgvaqtaaDMPDYRRLfSAIftdfhqfDRLqgPEGGE 422
Cdd:COG2401 49 LNLEIEPGEIVLIVGASGSGKSTLLRLLAGALkgTPVAGCVDVP-------DNQFGREA-SLI-------DAI--GRKGD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 423 PDTALvahwlERLNMK--SKLQFDGARVtnPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALR 500
Cdd:COG2401 112 FKDAV-----ELLNAVglSDAVLWLRRF--KELSTGQKFRFRLALLLAERPKLLVIDEFCSHLDRQTAKRVARNLQKLAR 184
|
170
....*....|...
gi 612265813 501 ALGKTVFAISHDD 513
Cdd:COG2401 185 RAGITLVVATHHY 197
|
|
| hmuV |
PRK13548 |
hemin importer ATP-binding subunit; Provisional |
346-530 |
9.14e-13 |
|
hemin importer ATP-binding subunit; Provisional
Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 68.26 E-value: 9.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV----------AQTAADMPDYRRL-FSaiFT--DFHQF 412
Cdd:PRK13548 22 SLTLRPGEVVAILGPNGAGKSTLLRALSGELSPDSGEVRLNGRpladwspaelARRRAVLPQHSSLsFP--FTveEVVAM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRLQGPEGGEPDTALVAHWLERLNMkskLQFDGARVtnPQLSQG--QRKRLALLLA----VAEQRDILLLDEWAADQDPQ 486
Cdd:PRK13548 100 GRAPHGLSRAEDDALVAAALAQVDL---AHLAGRDY--PQLSGGeqQRVQLARVLAqlwePDGPPRWLLLDEPTSALDLA 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 612265813 487 FRrifyRELLPALRAL----GKTVFAISHD----DHYfehADRLLEMRSGHL 530
Cdd:PRK13548 175 HQ----HHVLRLARQLaherGLAVIVVLHDlnlaARY---ADRIVLLHQGRL 219
|
|
| PRK13537 |
PRK13537 |
nodulation factor ABC transporter ATP-binding protein NodI; |
322-522 |
9.98e-13 |
|
nodulation factor ABC transporter ATP-binding protein NodI;
Pssm-ID: 237420 [Multi-domain] Cd Length: 306 Bit Score: 69.06 E-value: 9.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqqpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaqtaADMPDYRRL 401
Cdd:PRK13537 8 IDFRNVEKRYGDK-----LVVDGLSFHVQRGECFGLLGPNGAGKTTTLRMLLGLTHPDAGSISLCG-----EPVPSRARH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFHQFDRLqgpeggEPD---------------------TALVAHWLERLNMKSKLQfdgARVTnpQLSQGQRKR 460
Cdd:PRK13537 78 ARQRVGVVPQFDNL------DPDftvrenllvfgryfglsaaaaRALVPPLLEFAKLENKAD---AKVG--ELSGGMKRR 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 461 LALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAIShddHYFEHADRL 522
Cdd:PRK13537 147 LTLARALVNDPDVLVLDEPTTGLDPQARHLMW-ERLRSLLARGKTILLTT---HFMEEAERL 204
|
|
| ABC_MalK_N |
cd03301 |
The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ... |
322-533 |
1.09e-12 |
|
The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed.
Pssm-ID: 213268 [Multi-domain] Cd Length: 213 Bit Score: 67.28 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaaDMPDYRRL 401
Cdd:cd03301 1 VELENVTKRFGNVT-----ALDDLNLDIADGEFVVLLGPSGCGKTTTLRMIAGLEEPTSGRIYIGGRDVT--DLPPKDRD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDFhqfdrlqgpeggepdtALVAHWLERLNMKSKLQFDG-------ARVTN---------------PQLSQGQRK 459
Cdd:cd03301 74 IAMVFQNY----------------ALYPHMTVYDNIAFGLKLRKvpkdeidERVREvaellqiehlldrkpKQLSGGQRQ 137
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 460 RLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDdhYFEH---ADRLLEMRSGHLREL 533
Cdd:cd03301 138 RVALGRAIVREPKVFLMDEPLSNLDAKLRVQMRAELKRLQQRLGTTTIYVTHD--QVEAmtmADRIAVMNDGQIQQI 212
|
|
| PRK10908 |
PRK10908 |
cell division ATP-binding protein FtsE; |
345-530 |
1.17e-12 |
|
cell division ATP-binding protein FtsE;
Pssm-ID: 182829 [Multi-domain] Cd Length: 222 Bit Score: 67.59 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQT---AADMPDYRRLFSAIFTDFHQ------FDRL 415
Cdd:PRK10908 21 VTFHMRPGEMAFLTGHSGAGKSTLLKLICGIERPSAGKIWFSGHDITrlkNREVPFLRRQIGMIFQDHHLlmdrtvYDNV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 416 QGP-----EGGEPDTALVAHWLERLNMksklqFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRI 490
Cdd:PRK10908 101 AIPliiagASGDDIRRRVSAALDKVGL-----LDKAKNFPIQLSGGEQQRVGIARAVVNKPAVLLADEPTGNLDDALSEG 175
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 612265813 491 FYReLLPALRALGKTVFAISHDDHYFEHAD-RLLEMRSGHL 530
Cdd:PRK10908 176 ILR-LFEEFNRVGVTVLMATHDIGLISRRSyRMLTLSDGHL 215
|
|
| cbiO |
PRK13631 |
cobalt transporter ATP-binding subunit; Provisional |
348-530 |
1.58e-12 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 68.72 E-value: 1.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 348 TLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVL---------DGVAQTAADMP-------DYRRLFSAIFtdfhQ 411
Cdd:PRK13631 48 TFEKNKIYFIIGNSGSGKSTLVTHFNGLIKSKYGTIQVgdiyigdkkNNHELITNPYSkkiknfkELRRRVSMVF----Q 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 412 FDRLQ------------GPEG-GEPDT---ALVAHWLERLNMKSKLqFDgarvTNP-QLSQGQRKRLALLLAVAEQRDIL 474
Cdd:PRK13631 124 FPEYQlfkdtiekdimfGPVAlGVKKSeakKLAKFYLNKMGLDDSY-LE----RSPfGLSGGQKRRVAIAGILAIQPEIL 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 475 LLDEWAADQDPQFRRIFYRELLPAlRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK13631 199 IFDEPTAGLDPKGEHEMMQLILDA-KANNKTVFVITHTmEHVLEVADEVIVMDKGKI 254
|
|
| PhnL |
COG4778 |
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion ... |
346-528 |
1.60e-12 |
|
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism];
Pssm-ID: 443809 [Multi-domain] Cd Length: 229 Bit Score: 67.07 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHI-------VLDGVAQTAADMPDYRRlfsaiftdfH------QF 412
Cdd:COG4778 31 SFSVAAGECVALTGPSGAGKSTLLKCIYGNYLPDSGSIlvrhdggWVDLAQASPREILALRR---------RtigyvsQF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DR---------------LQgpEGGEPDTAL--VAHWLERLNMKSKLqFDGARVTnpqLSQGQRKRLALLLAVAEQRDILL 475
Cdd:COG4778 102 LRviprvsaldvvaeplLE--RGVDREEARarARELLARLNLPERL-WDLPPAT---FSGGEQQRVNIARGFIADPPLLL 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 612265813 476 LDEWAADQDPQFRRIFyRELLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSG 528
Cdd:COG4778 176 LDEPTASLDAANRAVV-VELIEEAKARGTAIIGIFHDEEVREAvADRVVDVTPF 228
|
|
| cbiO |
PRK13649 |
energy-coupling factor transporter ATPase; |
322-530 |
1.60e-12 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 68.23 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTA----ADMPD 397
Cdd:PRK13649 3 INLQNVSYTYQAGTPFEGRALFDVNLTIEDGSYTAFIGHTGSGKSTIMQLLNGLHVPTQGSVRVDDTLITStsknKDIKQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRRLFSAIFtdfhQFDRLQ------------GPE--GGEPDTAlVAHWLERLNMK--SKLQFDgarvTNP-QLSQGQRKR 460
Cdd:PRK13649 83 IRKKVGLVF----QFPESQlfeetvlkdvafGPQnfGVSQEEA-EALAREKLALVgiSESLFE----KNPfELSGGQMRR 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 461 LALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISH--DDhYFEHADRLLEMRSGHL 530
Cdd:PRK13649 154 VAIAGILAMEPKILVLDEPTAGLDPKGRKELM-TLFKKLHQSGMTIVLVTHlmDD-VANYADFVYVLEKGKL 223
|
|
| ABCC_MRP_domain2 |
cd03244 |
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ... |
345-532 |
2.04e-12 |
|
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.
Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 66.75 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFdrlQG------- 417
Cdd:cd03244 23 ISFSIKPGEKVGIVGRTGSGKSSLLLALFRLVELSSGSILIDGVDISKIGLHDLRSRISIIPQDPVLF---SGtirsnld 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 418 PEGGEPDTALvahW--LERLNMKS--KLQFDG--ARVTN--PQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ-FR 488
Cdd:cd03244 100 PFGEYSDEEL---WqaLERVGLKEfvESLPGGldTVVEEggENLSVGQRQLLCLARALLRKSKILVLDEATASVDPEtDA 176
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 612265813 489 RIfyRELLPALRAlGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:cd03244 177 LI--QKTIREAFK-DCTVLTIAHRLDTIIDSDRILVLDKGRVVE 217
|
|
| ABCF_EF-3 |
cd03221 |
ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is ... |
322-529 |
2.36e-12 |
|
ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP nucleotide binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.
Pssm-ID: 213188 [Multi-domain] Cd Length: 144 Bit Score: 64.39 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqqpGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLdgvaqtaadmpdyrrl 401
Cdd:cd03221 1 IELENLSKTYGG-----KLLLKDISLTINPGDRIGLVGRNGAGKSTLLKLIAGELEPDEGIVTW---------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 fsaiftdfhqfdrlqgpeggePDTALVAHWlerlnmksklqfdgarvtnPQLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03221 60 ---------------------GSTVKIGYF-------------------EQLSGGEKMRLALAKLLLENPNLLLLDEPTN 99
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 482 DQDpqfrrIFYRELL-PALRALGKTVFAISHdDHYF--EHADRLLEMRSGH 529
Cdd:cd03221 100 HLD-----LESIEALeEALKEYPGTVILVSH-DRYFldQVATKIIELEDGK 144
|
|
| MglA |
COG1129 |
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; |
322-530 |
2.65e-12 |
|
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];
Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 68.89 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYadaeqqPGFTVgpL---NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDY 398
Cdd:COG1129 5 LEMRGISKSF------GGVKA--LdgvSLELRPGEVHALLGENGAGKSTLMKILSGVYQPDSGEILLDGEPVRFRSPRDA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRL-FSAIFTDFHQFDRLQGPE----GGEPDTALVAHW----------LERLNmkskLQFD-GARVTNpqLSQGQRKRLA 462
Cdd:COG1129 77 QAAgIAIIHQELNLVPNLSVAEniflGREPRRGGLIDWramrrrarelLARLG----LDIDpDTPVGD--LSVAQQQLVE 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 463 LLLAVAEQRDILLLDE-WAADQDPQFRRIFyrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:COG1129 151 IARALSRDARVLILDEpTASLTEREVERLF--RIIRRLKAQGVAIIYISHRlDEVFEIADRVTVLRDGRL 218
|
|
| cbiO |
PRK13647 |
cobalt transporter ATP-binding subunit; Provisional |
322-528 |
2.74e-12 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 67.45 E-value: 2.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADM------ 395
Cdd:PRK13647 5 IEVEDLHFRYKDGTK----ALKGLSLSIPEGSKTALLGPNGAGKSTLLLHLNGIYLPQRGRVKVMGREVNAENEkwvrsk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 -------PDYRRLFSAIFTDFHQFDRLQGPEGGEPDTAlVAHWLERLNMKsklqfDGARVTNPQLSQGQRKRLALLLAVA 468
Cdd:PRK13647 81 vglvfqdPDDQVFSSTVWDDVAFGPVNMGLDKDEVERR-VEEALKAVRMW-----DFRDKPPYHLSYGQKKRVAIAGVLA 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 469 EQRDILLLDEWAADQDPQFRRIFyRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:PRK13647 155 MDPDVIVLDEPMAYLDPRGQETL-MEILDRLHNQGKTVIVATHDvDLAAEWADQVIVLKEG 214
|
|
| cbiO |
PRK13639 |
cobalt transporter ATP-binding subunit; Provisional |
322-530 |
4.41e-12 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 184199 [Multi-domain] Cd Length: 275 Bit Score: 66.64 E-value: 4.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYR 399
Cdd:PRK13639 2 LETRDLKYSYPDGTE----ALKGINFKAEKGEMVALLGPNGAGKSTLFLHFNGILKPTSGEVLIKGepIKYDKKSLLEVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDfhqfdrlqgpeggePDTALVAHWLER------LNMKSKLQFDGARVTNP---------------QLSQGQR 458
Cdd:PRK13639 78 KTVGIVFQN--------------PDDQLFAPTVEEdvafgpLNLGLSKEEVEKRVKEAlkavgmegfenkpphHLSGGQK 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612265813 459 KRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYReLLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK13639 144 KRVAIAGILAMKPEIIVLDEPTSGLDPMGASQIMK-LLYDLNKEGITIIISTHDvDLVPVYADKVYVMSDGKI 215
|
|
| cbiO |
PRK13646 |
energy-coupling factor transporter ATPase; |
345-532 |
8.32e-12 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 65.96 E-value: 8.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR--------LF----SAIFTDFHQF 412
Cdd:PRK13646 26 VNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRpvrkrigmVFqfpeSQLFEDTVER 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFY 492
Cdd:PRK13646 106 EIIFGPKNFKMNLDEVKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVLDEPTAGLDPQSKRQVM 185
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 612265813 493 RELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLRE 532
Cdd:PRK13646 186 RLLKSLQTDENKTIILVSHDmNEVARYADEVIVMKEGSIVS 226
|
|
| Uup |
COG0488 |
ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
346-535 |
9.39e-12 |
|
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];
Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 67.40 E-value: 9.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG------VAQTAaDMPDYRRLFSAIFTDF-------HQF 412
Cdd:COG0488 18 SLSINPGDRIGLVGRNGAGKSTLLKILAGELEPDSGEVSIPKglrigyLPQEP-PLDDDLTVLDTVLDGDaelraleAEL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRL-QGPEGGEPDTALVAHWLERLNMK-------------SKLQFDGARVTNP--QLSQGQRKRLALLLAVAEQRDILLL 476
Cdd:COG0488 97 EELeAKLAEPDEDLERLAELQEEFEALggweaearaeeilSGLGFPEEDLDRPvsELSGGWRRRVALARALLSEPDLLLL 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 477 DE-----------WAADQdpqfrrifyrellpaLRALGKTVFAISHdDHYF--EHADRLLEMRSGHLRELTG 535
Cdd:COG0488 177 DEptnhldlesieWLEEF---------------LKNYPGTVLVVSH-DRYFldRVATRILELDRGKLTLYPG 232
|
|
| ABC_DrrA |
cd03265 |
Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ... |
345-522 |
1.24e-11 |
|
Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213232 [Multi-domain] Cd Length: 220 Bit Score: 64.31 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaADMPDYRRLFSAIFTDFHQFDRLQGPEG---- 420
Cdd:cd03265 19 VSFRVRRGEIFGLLGPNGAGKTTTIKMLTTLLKPTSGRATVAGHDVV-REPREVRRRIGIVFQDLSVDDELTGWENlyih 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 ----GEPDTALVAHWLERLNMKSKLQFDGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELL 496
Cdd:cd03265 98 arlyGVPGAERRERIDELLDFVGLLEAADRLVKT--YSGGMRRRLEIARSLVHRPEVLFLDEPTIGLDPQTRAHVWEYIE 175
|
170 180
....*....|....*....|....*.
gi 612265813 497 PALRALGKTVFAIShddHYFEHADRL 522
Cdd:cd03265 176 KLKEEFGMTILLTT---HYMEEAEQL 198
|
|
| cbiO |
PRK13638 |
energy-coupling factor ABC transporter ATP-binding protein; |
322-530 |
1.52e-11 |
|
energy-coupling factor ABC transporter ATP-binding protein;
Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 65.03 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG-------------- 387
Cdd:PRK13638 2 LATSDLWFRYQDEPVLKG-----LNLDFSLSPVTGLVGANGCGKSTLFMNLSGLLRPQKGAVLWQGkpldyskrgllalr 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 388 --VAQTAADmPDYRRLFSAIFTDFHQFDRlqgpEGGEPDTALVAHWLERLNMKSKLQFDGARVTNpqLSQGQRKRLALLL 465
Cdd:PRK13638 77 qqVATVFQD-PEQQIFYTDIDSDIAFSLR----NLGVPEAEITRRVDEALTLVDAQHFRHQPIQC--LSHGQKKRVAIAG 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 466 AVAEQRDILLLDEWAADQDPQFRrifyRELLPALR---ALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK13638 150 ALVLQARYLLLDEPTAGLDPAGR----TQMIAIIRrivAQGNHVIISSHDiDLIYEISDAVYVLRQGQI 214
|
|
| ModF |
COG1119 |
ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ... |
322-511 |
2.02e-11 |
|
ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism];
Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 64.34 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgftVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSG-HIVLDGVAQTAADMPDYRR 400
Cdd:COG1119 4 LELRNVTVRRGGKTI-----LDDISWTVKPGEHWAILGPNGAGKSTLLSLITGDLPPTYGnDVRLFGERRGGEDVWELRK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 ---LFSAIFTdfHQFDR--------LQG--------PEGGEPDTALVAHWLERLNMKSKLQ--FDgarvtnpQLSQGQRK 459
Cdd:COG1119 79 rigLVSPALQ--LRFPRdetvldvvLSGffdsiglyREPTDEQRERARELLELLGLAHLADrpFG-------TLSQGEQR 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 612265813 460 RLALLLAVAEQRDILLLDEWAADQDPQFRRIFyRELLPALRALGKT--VFaISH 511
Cdd:COG1119 150 RVLIARALVKDPELLILDEPTAGLDLGARELL-LALLDKLAAEGAPtlVL-VTH 201
|
|
| YhaQ |
COG4152 |
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ... |
321-536 |
2.25e-11 |
|
ABC-type uncharacterized transport system, ATPase component [General function prediction only];
Pssm-ID: 443322 [Multi-domain] Cd Length: 298 Bit Score: 64.74 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFHYADaeqqpgFT-VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD----- 394
Cdd:COG4152 1 MLELKGLTKRFGD------KTaVDDVSFTVPKGEIFGLLGPNGAGKTTTIRIILGILAPDSGEVLWDGEPLDPEDrrrig 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 395 -MPDYRRLFS-------AIFtdfhqFDRLQGPEGGEPDTALvAHWLERLNM----KSKLQfdgarvtnpQLSQGQRKRLA 462
Cdd:COG4152 75 yLPEERGLYPkmkvgeqLVY-----LARLKGLSKAEAKRRA-DEWLERLGLgdraNKKVE---------ELSKGNQQKVQ 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLpALRALGKTV-FAiSHD-DHYFEHADRLLEMRSGHLReLTGS 536
Cdd:COG4152 140 LIAALLHDPELLILDEPFSGLDPVNVELLKDVIR-ELAAKGTTViFS-SHQmELVEELCDRIVIINKGRKV-LSGS 212
|
|
| cbiO |
PRK13643 |
energy-coupling factor transporter ATPase; |
345-530 |
3.42e-11 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 64.37 E-value: 3.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAA----DMPDYRRLFSAIFtdfhQFDRLQ---- 416
Cdd:PRK13643 25 IDLEVKKGSYTALIGHTGSGKSTLLQHLNGLLQPTEGKVTVGDIVVSSTskqkEIKPVRKKVGVVF----QFPESQlfee 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 --------GPE----GGEPDTALVAHWLERLNMKSKLQfdgaRVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQD 484
Cdd:PRK13643 101 tvlkdvafGPQnfgiPKEKAEKIAAEKLEMVGLADEFW----EKSPFELSGGQMRRVAIAGILAMEPEVLVLDEPTAGLD 176
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 612265813 485 PQfRRIFYRELLPALRALGKTVFAISH-DDHYFEHADRLLEMRSGHL 530
Cdd:PRK13643 177 PK-ARIEMMQLFESIHQSGQTVVLVTHlMDDVADYADYVYLLEKGHI 222
|
|
| ABC_NatA_like |
cd03267 |
ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ... |
345-530 |
3.46e-11 |
|
ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.
Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 63.51 E-value: 3.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHI-VLDGVAQTaaDMPDYRRLFSAIFTDFHQ----------FD 413
Cdd:cd03267 40 ISFTIEKGEIVGFIGPNGAGKTTTLKILSGLLQPTSGEVrVAGLVPWK--RRKKFLRRIGVVFGQKTQlwwdlpvidsFY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 414 RLQGPEGGEPdtalvAHWLERLNMKSKLQFDGARVTNP--QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIF 491
Cdd:cd03267 118 LLAAIYDLPP-----ARFKKRLDELSELLDLEELLDTPvrQLSLGQRMRAEIAAALLHEPEILFLDEPTIGLDVVAQENI 192
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 612265813 492 YRELLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHL 530
Cdd:cd03267 193 RNFLKEYNRERGTTVLLTSHYMKDIEAlARRVLVIDKGRL 232
|
|
| ABCC_NFT1 |
cd03369 |
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ... |
346-532 |
5.04e-11 |
|
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate.
Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 62.43 E-value: 5.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLR--RGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFDrlqgpeggep 423
Cdd:cd03369 26 NVSFKvkAGEKIGIVGRTGAGKSTLILALFRFLEAEEGKIEIDGIDISTIPLEDLRSSLTIIPQDPTLFS---------- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 424 dtALVAHWLERLNMKSKLQFDGA-RVTN--PQLSQGQRKRLALLLAVAEQRDILLLDEWAA----DQDPQFRRIFYRELl 496
Cdd:cd03369 96 --GTIRSNLDPFDEYSDEEIYGAlRVSEggLNLSQGQRQLLCLARALLKRPRVLVLDEATAsidyATDALIQKTIREEF- 172
|
170 180 190
....*....|....*....|....*....|....*.
gi 612265813 497 palraLGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:cd03369 173 -----TNSTILTIAHRLRTIIDYDKILVMDAGEVKE 203
|
|
| PRK10851 |
PRK10851 |
sulfate/thiosulfate ABC transporter ATP-binding protein CysA; |
345-543 |
6.12e-11 |
|
sulfate/thiosulfate ABC transporter ATP-binding protein CysA;
Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 63.95 E-value: 6.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFS----AIFTDFHQFDRLQ-G-- 417
Cdd:PRK10851 21 ISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVSRLHARDRKVGFVfqhyALFRHMTVFDNIAfGlt 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 418 --PEGGEPDTALVAHWLERLNMKSKLQFDGARVTNpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRrifyREL 495
Cdd:PRK10851 101 vlPRRERPNAAAIKAKVTQLLEMVQLAHLADRYPA-QLSGGQKQRVALARALAVEPQILLLDEPFGALDAQVR----KEL 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 496 LPALRALGK-----TVFaISHD-DHYFEHADRLLEMRSGHLRELTGSE---REHASR 543
Cdd:PRK10851 176 RRWLRQLHEelkftSVF-VTHDqEEAMEVADRVVVMSQGNIEQAGTPDqvwREPATR 231
|
|
| NupO |
COG3845 |
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
346-528 |
6.36e-11 |
|
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];
Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 64.66 E-value: 6.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL-FSAIFTDFHQFDRL--------- 415
Cdd:COG3845 25 SLTVRPGEIHALLGENGAGKSTLMKILYGLYQPDSGEILIDGKPVRIRSPRDAIALgIGMVHQHFMLVPNLtvaenivlg 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 416 -QGPEGGEPDTALVAHWLERLNMKSKLQFD-GARVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYr 493
Cdd:COG3845 105 lEPTKGGRLDRKAARARIRELSERYGLDVDpDAKVE--DLSVGEQQRVEILKALYRGARILILDEPTAVLTPQEADELF- 181
|
170 180 190
....*....|....*....|....*....|....*.
gi 612265813 494 ELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:COG3845 182 EILRRLAAEGKSIIFITHKlREVMAIADRVTVLRRG 217
|
|
| cbiO |
PRK13652 |
cobalt transporter ATP-binding subunit; Provisional |
322-528 |
8.95e-11 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 172200 [Multi-domain] Cd Length: 277 Bit Score: 62.90 E-value: 8.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:PRK13652 4 IETRDLCYSYSGSKE----ALNNINFIAPRNSRIAVIGPNGAGKSTLFRHFNGILKPTSGSVLIRGEPITKENIREVRKF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIF--TDFHQF------DRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNpQLSQGQRKRLALLLAVAEQRDI 473
Cdd:PRK13652 80 VGLVFqnPDDQIFsptveqDIAFGPINLGLDEETVAHRVSSALHMLGLEELRDRVPH-HLSGGEKKRVAIAGVIAMEPQV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 474 LLLDEWAADQDPQFRrifyRELLPALRALGKT-----VFAISHDDHYFEHADRLLEMRSG 528
Cdd:PRK13652 159 LVLDEPTAGLDPQGV----KELIDFLNDLPETygmtvIFSTHQLDLVPEMADYIYVMDKG 214
|
|
| ABC_PstB_phosphate_transporter |
cd03260 |
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ... |
322-485 |
1.12e-10 |
|
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).
Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 61.81 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLY-----RPVSGHIVLDGVAQTAADMP 396
Cdd:cd03260 1 IELRDLNVYYGDKHALKD-----ISLDIPKGEITALIGPSGCGKSTLLRLLNRLNdlipgAPDEGEVLLDGKDIYDLDVD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 397 DY--RRLFSAIF---TDFHQ--FD------RLQGPEGGEPDTALVAHWLERL----NMKSKLQFDGarvtnpqLSQGQRK 459
Cdd:cd03260 76 VLelRRRVGMVFqkpNPFPGsiYDnvayglRLHGIKLKEELDERVEEALRKAalwdEVKDRLHALG-------LSGGQQQ 148
|
170 180
....*....|....*....|....*.
gi 612265813 460 RLALLLAVAEQRDILLLDEWAADQDP 485
Cdd:cd03260 149 RLCLARALANEPEVLLLDEPTSALDP 174
|
|
| CeuD |
COG4604 |
ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and ... |
323-528 |
1.45e-10 |
|
ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism];
Pssm-ID: 443654 [Multi-domain] Cd Length: 252 Bit Score: 61.64 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADmpDY-R 399
Cdd:COG4604 3 EIKNVSKRYGGKV-----VLDDVSLTIPKGGITALIGPNGAGKSTLLSMISRLLPPDSGEVLVDGldVATTPSR--ELaK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLfsAIFTDFHQFD-RL--------------QGPEGGEpDTALVAHWLERLNMKSkLQ---FDgarvtnpQLSQGQRKRL 461
Cdd:COG4604 76 RL--AILRQENHINsRLtvrelvafgrfpysKGRLTAE-DREIIDEAIAYLDLED-LAdryLD-------ELSGGQRQRA 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 462 ALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD----DHYfehADRLLEMRSG 528
Cdd:COG4604 145 FIAMVLAQDTDYVLLDEPLNNLDMKHSVQMMKLLRRLADELGKTVVIVLHDinfaSCY---ADHIVAMKDG 212
|
|
| PRK10535 |
PRK10535 |
macrolide ABC transporter ATP-binding protein/permease MacB; |
322-541 |
2.02e-10 |
|
macrolide ABC transporter ATP-binding protein/permease MacB;
Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 63.59 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPD---- 397
Cdd:PRK10535 5 LELKDIRRSYPSGEEQVEVLKG-ISLDIYAGEMVAIVGASGSGKSTLMNILGCLDKPTSGTYRVAG--QDVATLDAdala 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 --YRRLFSAIFTDFHQFDRLQGPE--------GGEPDTALVAH---WLERLNMKSKLQFDGArvtnpQLSQGQRKRLALL 464
Cdd:PRK10535 82 qlRREHFGFIFQRYHLLSHLTAAQnvevpavyAGLERKQRLLRaqeLLQRLGLEDRVEYQPS-----QLSGGQQQRVSIA 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 465 LAVAEQRDILLLDEWAADQDPQfRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSEREHA 541
Cdd:PRK10535 157 RALMNGGQVILADEPTGALDSH-SGEEVMAILHQLRDRGHTVIIVTHDPQVAAQAERVIEIRDGEIVRNPPAQEKVN 232
|
|
| ABC_TM1139_LivF_branched |
cd03224 |
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ... |
322-529 |
2.31e-10 |
|
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.
Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 60.53 E-value: 2.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadMPDYRRL 401
Cdd:cd03224 1 LEVENLNAGYGKSQILFG-----VSLTVPEGEIVALLGRNGAGKTTLLKTIMGLLPPRSGSIRFDGRDITG--LPPHERA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FS---------AIFTDFHQFDRLQ-----GPEGGEPDTalvahwLER-LNMKSKLQfdgARVTNP--QLSQGQRKRLALL 464
Cdd:cd03224 74 RAgigyvpegrRIFPELTVEENLLlgayaRRRAKRKAR------LERvYELFPRLK---ERRKQLagTLSGGEQQMLAIA 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 465 LAVAEQRDILLLDEWAADQDPQF-RRIFyrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGH 529
Cdd:cd03224 145 RALMSRPKLLLLDEPSEGLAPKIvEEIF--EAIRELRDEGVTILLVEQNaRFALEIADRAYVLERGR 209
|
|
| PRK13657 |
PRK13657 |
glucan ABC transporter ATP-binding protein/ permease; |
323-532 |
2.58e-10 |
|
glucan ABC transporter ATP-binding protein/ permease;
Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 63.06 E-value: 2.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLF 402
Cdd:PRK13657 336 EFDDVSFSYDNSRQ----GVEDVSFEAKPGQTVAIVGPTGAGKSTLINLLQRVFDPQSGRILIDGTDIRTVTRASLRRNI 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFTDFHQFDR-------LQGPEGGEPDTALVAHWLERLN--MKSKLQFD---GARvtNPQLSQGQRKRLALLLAVAEQ 470
Cdd:PRK13657 412 AVVFQDAGLFNRsiednirVGRPDATDEEMRAAAERAQAHDfiERKPDGYDtvvGER--GRQLSGGERQRLAIARALLKD 489
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 471 RDILLLDEWAADQDPQFRrifyRELLPALRAL--GKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PRK13657 490 PPILILDEATSALDVETE----AKVKAALDELmkGRTTFIIAHRLSTVRNADRILVFDNGRVVE 549
|
|
| PRK10070 |
PRK10070 |
proline/glycine betaine ABC transporter ATP-binding protein ProV; |
346-530 |
2.93e-10 |
|
proline/glycine betaine ABC transporter ATP-binding protein ProV;
Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 62.36 E-value: 2.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV---AQTAADMPDYRRL-FSAIFTDFHQFDRLQGPEGG 421
Cdd:PRK10070 48 SLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVdiaKISDAELREVRRKkIAMVFQSFALMPHMTVLDNT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 422 EPDTALVAHWLERLNMKSKLQFDGARVTN------PQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYREL 495
Cdd:PRK10070 128 AFGMELAGINAEERREKALDALRQVGLENyahsypDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDEL 207
|
170 180 190
....*....|....*....|....*....|....*.
gi 612265813 496 LPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK10070 208 VKLQAKHQRTIVFISHDlDEAMRIGDRIAIMQNGEV 243
|
|
| PRK11831 |
PRK11831 |
phospholipid ABC transporter ATP-binding protein MlaF; |
322-512 |
3.24e-10 |
|
phospholipid ABC transporter ATP-binding protein MlaF;
Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 60.93 E-value: 3.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqQPGFTvgPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG---VAQTAADMPDY 398
Cdd:PRK11831 8 VDMRGVSFTRGN---RCIFD--NISLTVPRGKITAIMGPSGIGKTTLLRLIGGQIAPDHGEILFDGeniPAMSRSRLYTV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFS------AIFTDFHQFDRLQGPEggEPDTALVAHWLERLNMKsKLQFDG----ARVTNPQLSQGQRKRLALLLAVA 468
Cdd:PRK11831 83 RKRMSmlfqsgALFTDMNVFDNVAYPL--REHTQLPAPLLHSTVMM-KLEAVGlrgaAKLMPSELSGGMARRAALARAIA 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 612265813 469 EQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD 512
Cdd:PRK11831 160 LEPDLIMFDEPFVGQDPITMGVLVKLISELNSALGVTCVVVSHD 203
|
|
| thiQ |
PRK10771 |
thiamine ABC transporter ATP-binding protein ThiQ; |
346-488 |
3.99e-10 |
|
thiamine ABC transporter ATP-binding protein ThiQ;
Pssm-ID: 182716 [Multi-domain] Cd Length: 232 Bit Score: 59.98 E-value: 3.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAadMPDYRRLFSAIFTDFHQFDRLQgpegGEPDT 425
Cdd:PRK10771 19 DLTVERGERVAILGPSGAGKSTLLNLIAGFLTPASGSLTLNGQDHTT--TPPSRRPVSMLFQENNLFSHLT----VAQNI 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612265813 426 ALVAHWLERLN--MKSKLQFDGARVT--------NPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFR 488
Cdd:PRK10771 93 GLGLNPGLKLNaaQREKLHAIARQMGiedllarlPGQLSGGQRQRVALARCLVREQPILLLDEPFSALDPALR 165
|
|
| lolD |
PRK11629 |
lipoprotein-releasing ABC transporter ATP-binding protein LolD; |
349-537 |
5.48e-10 |
|
lipoprotein-releasing ABC transporter ATP-binding protein LolD;
Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 59.83 E-value: 5.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 349 LRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG-----VAQTAADMPDYRRL-----FSAIFTDFHQFDRLQGP 418
Cdd:PRK11629 32 IGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGqpmskLSSAAKAELRNQKLgfiyqFHHLLPDFTALENVAMP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 419 ---EGGEPDTA-------LVAHWLE-RLNMKSKlqfdgarvtnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ- 486
Cdd:PRK11629 112 lliGKKKPAEInsralemLAAVGLEhRANHRPS-----------ELSGGERQRVAIARALVNNPRLVLADEPTGNLDARn 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 487 FRRIFyrELLPALRALGKTVF-AISHDDHYFEHADRLLEMRSGHLRE---LTGSE 537
Cdd:PRK11629 181 ADSIF--QLLGELNRLQGTAFlVVTHDLQLAKRMSRQLEMRDGRLTAelsLMGAE 233
|
|
| fecE |
PRK11231 |
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
345-530 |
5.63e-10 |
|
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;
Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 60.03 E-value: 5.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSaiFTDFHqfdrLQGPEG---- 420
Cdd:PRK11231 21 LSLSLPTGKITALIGPNGCGKSTLLKCFARLLTPQSGTVFLGDKPISMLSSRQLARRLA--LLPQH----HLTPEGitvr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 -----------------GEPDTALVAHWLERLNMkskLQFDGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAA-- 481
Cdd:PRK11231 95 elvaygrspwlslwgrlSAEDNARVNQAMEQTRI---NHLADRRLTD--LSGGQRQRAFLAMVLAQDTPVVLLDEPTTyl 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612265813 482 DQDPQFrrifyrELLPALRAL---GKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK11231 170 DINHQV------ELMRLMRELntqGKTVVTVLHDlNQASRYCDHLVVLANGHV 216
|
|
| DppD |
COG0444 |
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ... |
345-478 |
7.02e-10 |
|
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];
Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 60.45 E-value: 7.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRP---VSGHIVLDGVAQTAADMPDYRRL----FSAIFTD--------- 408
Cdd:COG0444 24 VSFDVRRGETLGLVGESGSGKSTLARAILGLLPPpgiTSGEILFDGEDLLKLSEKELRKIrgreIQMIFQDpmtslnpvm 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 409 --FHQFD---RLQGPEGGEPDTALVAHWLERLNMKsklqfDGARVTN--P-QLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:COG0444 104 tvGDQIAeplRIHGGLSKAEARERAIELLERVGLP-----DPERRLDryPhELSGGMRQRVMIARALALEPKLLIADE 176
|
|
| PRK13543 |
PRK13543 |
heme ABC exporter ATP-binding protein CcmA; |
343-506 |
1.09e-09 |
|
heme ABC exporter ATP-binding protein CcmA;
Pssm-ID: 184129 [Multi-domain] Cd Length: 214 Bit Score: 58.71 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 343 GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD----------MPDYRRLFSAIfTDFHQF 412
Cdd:PRK13543 28 GPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVESGQIQIDGKTATRGDrsrfmaylghLPGLKADLSTL-ENLHFL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRLQGPEGGE-PDTALVAHWLErlnmksklqfDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIF 491
Cdd:PRK13543 107 CGLHGRRAKQmPGSALAIVGLA----------GYEDTLVRQLSAGQKKRLALARLWLSPAPLWLLDEPYANLDLEGITLV 176
|
170
....*....|....*
gi 612265813 492 YRELLPALRALGKTV 506
Cdd:PRK13543 177 NRMISAHLRGGGAAL 191
|
|
| nikE |
PRK10419 |
nickel ABC transporter ATP-binding protein NikE; |
347-532 |
1.14e-09 |
|
nickel ABC transporter ATP-binding protein NikE;
Pssm-ID: 236689 [Multi-domain] Cd Length: 268 Bit Score: 59.32 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 347 LTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTA---ADMPDYRRLFSAIFTD-FHQFD--RLQGPEG 420
Cdd:PRK10419 33 LSLKSGETVALLGRSGCGKSTLARLLVGLESPSQGNVSWRGEPLAKlnrAQRKAFRRDIQMVFQDsISAVNprKTVREII 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 GEP--------DTALVAHWLERLNMkSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDP--QFRRI 490
Cdd:PRK10419 113 REPlrhllsldKAERLARASEMLRA-VDLDDSVLDKRPPQLSGGQLQRVCLARALAVEPKLLILDEAVSNLDLvlQAGVI 191
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 612265813 491 fyrELLPALRALGKTVFA-ISHDDHYFEH-ADRLLEMRSGHLRE 532
Cdd:PRK10419 192 ---RLLKKLQQQFGTACLfITHDLRLVERfCQRVMVMDNGQIVE 232
|
|
| PLN03232 |
PLN03232 |
ABC transporter C family member; Provisional |
247-532 |
1.18e-09 |
|
ABC transporter C family member; Provisional
Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 61.53 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 247 IGLVFFMANSLGWADSTVAATYSLTLLF--LRTPLLQAVGAFPTLVGAEVAFNKLKALRLAE---------YQSGFPAav 315
Cdd:PLN03232 537 VTLVSFGVFVLLGGDLTPARAFTSLSLFavLRSPLNMLPNLLSQVVNANVSLQRIEELLLSEerilaqnppLQPGAPA-- 614
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 316 grswqtLELRDVVFHYADAEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPV-SGHIVLDGvaqTAAD 394
Cdd:PLN03232 615 ------ISIKNGYFSWDSKTSKP--TLSDINLEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAeTSSVVIRG---SVAY 683
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 395 MPDYRRLFSAIFTDFHQFDRLQGPE--GGEPDTALVAHWLERLNMKSKLQFdGARVTNpqLSQGQRKRLALLLAVAEQRD 472
Cdd:PLN03232 684 VPQVSWIFNATVRENILFGSDFESEryWRAIDVTALQHDLDLLPGRDLTEI-GERGVN--ISGGQKQRVSMARAVYSNSD 760
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 473 ILLLDEWAADQDPQF-RRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PLN03232 761 IYIFDDPLSALDAHVaHQVFDSCMKDELK--GKTRVLVTNQLHFLPLMDRIILVSEGMIKE 819
|
|
| ABC_YhbG |
cd03218 |
ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the ... |
345-485 |
1.21e-09 |
|
ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.
Pssm-ID: 213185 [Multi-domain] Cd Length: 232 Bit Score: 58.71 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaaDMPDYRRLF---------SAIFTD------- 408
Cdd:cd03218 19 VSLSVKQGEIVGLLGPNGAGKTTTFYMIVGLVKPDSGKILLDGQDIT--KLPMHKRARlgigylpqeASIFRKltveeni 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 409 -----FHQFDRlqgpeggepdtalvAHWLERLN-MKSKLQFDGARVTN-PQLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:cd03218 97 lavleIRGLSK--------------KEREEKLEeLLEEFHITHLRKSKaSSLSGGERRRVEIARALATNPKFLLLDEPFA 162
|
....
gi 612265813 482 DQDP 485
Cdd:cd03218 163 GVDP 166
|
|
| fbpC |
PRK11432 |
ferric ABC transporter ATP-binding protein; |
345-530 |
1.30e-09 |
|
ferric ABC transporter ATP-binding protein;
Pssm-ID: 183133 [Multi-domain] Cd Length: 351 Bit Score: 60.12 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG--VAQTAADMPDYRRLFS--AIFTDFHQFD------R 414
Cdd:PRK11432 25 LNLTIKQGTMVTLLGPSGCGKTTVLRLVAGLEKPTEGQIFIDGedVTHRSIQQRDICMVFQsyALFPHMSLGEnvgyglK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 415 LQGPEGGEPDTAlVAHWLERLNMKSklqFDGARVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFyRE 494
Cdd:PRK11432 105 MLGVPKEERKQR-VKEALELVDLAG---FEDRYVD--QISGGQQQRVALARALILKPKVLLFDEPLSNLDANLRRSM-RE 177
|
170 180 190
....*....|....*....|....*....|....*...
gi 612265813 495 LLPAL-RALGKTVFAISHDD-HYFEHADRLLEMRSGHL 530
Cdd:PRK11432 178 KIRELqQQFNITSLYVTHDQsEAFAVSDTVIVMNKGKI 215
|
|
| PRK10253 |
PRK10253 |
iron-enterobactin ABC transporter ATP-binding protein; |
345-549 |
1.38e-09 |
|
iron-enterobactin ABC transporter ATP-binding protein;
Pssm-ID: 182336 [Multi-domain] Cd Length: 265 Bit Score: 59.23 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA-QTAADMPDYRR---LFSAIFTDFHQFDRLQGPEG 420
Cdd:PRK10253 26 LTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLMTPAHGHVWLDGEHiQHYASKEVARRiglLAQNATTPGDITVQELVARG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 GEPDTALVAHWLER------LNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQfRRIFYRE 494
Cdd:PRK10253 106 RYPHQPLFTRWRKEdeeavtKAMQATGITHLADQSVDTLSGGQRQRAWIAMVLAQETAIMLLDEPTTWLDIS-HQIDLLE 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 495 LLPAL-RALGKTVFAISHD-DHYFEHADRLLEMRSGHLRElTGSEREHASRDSVSRI 549
Cdd:PRK10253 185 LLSELnREKGYTLAAVLHDlNQACRYASHLIALREGKIVA-QGAPKEIVTAELIERI 240
|
|
| YnjD |
COG4136 |
ABC-type uncharacterized transport system YnjBCD, ATPase component [General function ... |
321-512 |
1.38e-09 |
|
ABC-type uncharacterized transport system YnjBCD, ATPase component [General function prediction only];
Pssm-ID: 443311 [Multi-domain] Cd Length: 211 Bit Score: 58.26 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFHYADAEQqpgftVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRP---VSGHIVLDGVAQTAadMPD 397
Cdd:COG4136 1 MLSLENLTITLGGRPL-----LAPLSLTVAPGEILTLMGPSGSGKSTLLAAIAGTLSPafsASGEVLLNGRRLTA--LPA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRRLFSAIFTDFHQFDRL-----------QGPEGGEPDtALVAHWLERLNMKSKLQFDGArvtnpQLSQGQRKRLALLLA 466
Cdd:COG4136 74 EQRRIGILFQDDLLFPHLsvgenlafalpPTIGRAQRR-ARVEQALEEAGLAGFADRDPA-----TLSGGQRARVALLRA 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 612265813 467 VAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD 512
Cdd:COG4136 148 LLAEPRALLLDEPFSKLDAALRAQFREFVFEQIRQRGIPALLVTHD 193
|
|
| met_CoM_red_A2 |
TIGR03269 |
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
322-530 |
1.67e-09 |
|
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]
Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 60.20 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDgVAQTAADM----PD 397
Cdd:TIGR03269 280 IKVRNVSKRYISVDRGVVKAVDNVSLEVKEGEIFGIVGTSGAGKTTLSKIIAGVLEPTSGEVNVR-VGDEWVDMtkpgPD 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 398 YRRLFSAIFTDFHQ----------FDRLQGPEGGE-PDTALVAHWLERLNMkskLQFDGARVTN------PQLSQGQRKR 460
Cdd:TIGR03269 359 GRGRAKRYIGILHQeydlyphrtvLDNLTEAIGLElPDELARMKAVITLKM---VGFDEEKAEEildkypDELSEGERHR 435
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 461 LALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:TIGR03269 436 VALAQVLIKEPRIVILDEPTGTMDPITKVDVTHSILKAREEMEQTFIIVSHDmDFVLDVCDRAALMRDGKI 506
|
|
| ABC_Carb_Monos_II |
cd03215 |
Second domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
322-530 |
2.09e-09 |
|
Second domain of the ATP-binding cassette component of monosaccharide transport system; This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. In members of Carb_Monos family the single hydrophobic gene product forms a homodimer, while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.
Pssm-ID: 213182 [Multi-domain] Cd Length: 182 Bit Score: 57.06 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYAdaeqqpgftVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:cd03215 5 LEVRGLSVKGA---------VRDVSFEVRAGEIVGIAGLVGNGQTELAEALFGLRPPASGEITLDGKPVTRRSPRDAIRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFTDfhqfDRLQgpeggepdTALVAHWLERLNMksklqfdgarVTNPQLSQG-QRKrlaLLLA--VAEQRDILLLDE 478
Cdd:cd03215 76 GIAYVPE----DRKR--------EGLVLDLSVAENI----------ALSSLLSGGnQQK---VVLArwLARDPRVLILDE 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612265813 479 WAADQDPQFRRIFYRELLpALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:cd03215 131 PTRGVDVGAKAEIYRLIR-ELADAGKAVLLISSElDELLGLCDRILVMYEGRI 182
|
|
| PRK13538 |
PRK13538 |
cytochrome c biogenesis heme-transporting ATPase CcmA; |
345-478 |
2.35e-09 |
|
cytochrome c biogenesis heme-transporting ATPase CcmA;
Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 57.51 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADmPDYRR--LF----SAIFTDFHQFDRLQ-- 416
Cdd:PRK13538 20 LSFTLNAGELVQIEGPNGAGKTSLLRILAGLARPDAGEVLWQGEPIRRQR-DEYHQdlLYlghqPGIKTELTALENLRfy 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 417 GPEGGEPDTALVAHWLERLNMKSKlqfdgARVTNPQLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:PRK13538 99 QRLHGPGDDEALWEALAQVGLAGF-----EDVPVRQLSAGQQRRVALARLWLTRAPLWILDE 155
|
|
| PRK10247 |
PRK10247 |
putative ABC transporter ATP-binding protein YbbL; Provisional |
322-541 |
3.43e-09 |
|
putative ABC transporter ATP-binding protein YbbL; Provisional
Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 57.42 E-value: 3.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL 401
Cdd:PRK10247 8 LQLQNVGYLAGDAK-----ILNNISFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEGEDISTLKPEIYRQQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FS------AIFTDfHQFDRLQGP---EGGEPDTALVAHWLERLNM-KSKLQfdgARVTnpQLSQGQRKRLALLLAVAEQR 471
Cdd:PRK10247 83 VSycaqtpTLFGD-TVYDNLIFPwqiRNQQPDPAIFLDDLERFALpDTILT---KNIA--ELSGGEKQRISLIRNLQFMP 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 472 DILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSgHLRELTGSEREHA 541
Cdd:PRK10247 157 KVLLLDEITSALDESNKHNVNEIIHRYVREQNIAVLWVTHDKDEINHADKVITLQP-HAGEMQEARYELA 225
|
|
| PRK13539 |
PRK13539 |
cytochrome c biogenesis protein CcmA; Provisional |
345-478 |
3.48e-09 |
|
cytochrome c biogenesis protein CcmA; Provisional
Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 56.81 E-value: 3.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTaadmpdyrrlFSAIFTDFH-------------- 410
Cdd:PRK13539 21 LSFTLAAGEALVLTGPNGSGKTTLLRLIAGLLPPAAGTIKLDGGDID----------DPDVAEACHylghrnamkpaltv 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 411 ----QF-DRLQGPEGGEPDTALVAhwlerlnmksklqFDGARVTNPQ---LSQGQRKRLAL--LLAVaeQRDILLLDE 478
Cdd:PRK13539 91 aenlEFwAAFLGGEELDIAAALEA-------------VGLAPLAHLPfgyLSAGQKRRVALarLLVS--NRPIWILDE 153
|
|
| SufC |
COG0396 |
Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, ... |
345-387 |
3.54e-09 |
|
Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440165 [Multi-domain] Cd Length: 245 Bit Score: 57.38 E-value: 3.54e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGL--YRPVSGHIVLDG 387
Cdd:COG0396 19 VNLTIKPGEVHAIMGPNGSGKSTLAKVLMGHpkYEVTSGSILLDG 63
|
|
| livF |
PRK11614 |
high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF; |
322-530 |
4.48e-09 |
|
high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;
Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 57.20 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA----QTAADM-- 395
Cdd:PRK11614 6 LSFDKVSAHYGKIQ-----ALHEVSLHINQGEIVTLIGANGAGKTTLLGTLCGDPRATSGRIVFDGKDitdwQTAKIMre 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 -----PDYRRLFSAIFTDFHQ------FDRLQGPEGGEPDTALVAHWLERlnmksKLQFDGArvtnpqLSQGQRKRLALL 464
Cdd:PRK11614 81 avaivPEGRRVFSRMTVEENLamggffAERDQFQERIKWVYELFPRLHER-----RIQRAGT------MSGGEQQMLAIG 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 465 LAVAEQRDILLLDEWAADQDP-QFRRIFyrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK11614 150 RALMSQPRLLLLDEPSLGLAPiIIQQIF--DTIEQLREQGMTIFLVEQNaNQALKLADRGYVLENGHV 215
|
|
| rim_protein |
TIGR01257 |
retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ... |
342-522 |
7.58e-09 |
|
retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]
Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 58.87 E-value: 7.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIV---------LDGVAQTAADMPDYRRLFSAIFTDFHQ- 411
Cdd:TIGR01257 946 VDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLvggkdietnLDAVRQSLGMCPQHNILFHHLTVAEHIl 1025
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 412 -FDRLQGPEGGEPdtalvahwleRLNMKSKLQFDG---ARVTNPQ-LSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:TIGR01257 1026 fYAQLKGRSWEEA----------QLEMEAMLEDTGlhhKRNEEAQdLSGGMQRKLSVAIAFVGDAKVVVLDEPTSGVDPY 1095
|
170 180 190
....*....|....*....|....*....|....*.
gi 612265813 487 FRRIFYrELLPALRAlGKTVFAIShddHYFEHADRL 522
Cdd:TIGR01257 1096 SRRSIW-DLLLKYRS-GRTIIMST---HHMDEADLL 1126
|
|
| PRK10584 |
PRK10584 |
putative ABC transporter ATP-binding protein YbbA; Provisional |
322-532 |
1.06e-08 |
|
putative ABC transporter ATP-binding protein YbbA; Provisional
Pssm-ID: 182569 [Multi-domain] Cd Length: 228 Bit Score: 55.94 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGFTVGpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADmPDYRRL 401
Cdd:PRK10584 7 VEVHHLKKSVGQGEHELSILTG-VELVVKRGETIALIGESGSGKSTLLAILAGLDDGSSGEVSLVGQPLHQMD-EEARAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSA-----IFTDFHQFDRLQGPEG--------GEPDT---ALVAHWLERLNMKSKLQFDGArvtnpQLSQGQRKRLALLL 465
Cdd:PRK10584 85 LRAkhvgfVFQSFMLIPTLNALENvelpallrGESSRqsrNGAKALLEQLGLGKRLDHLPA-----QLSGGEQQRVALAR 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 466 AVAEQRDILLLDEWAADQDPQF-RRIfyRELLPAL-RALGKTVFAISHDDHYFEHADRLLEMRSGHLRE 532
Cdd:PRK10584 160 AFNGRPDVLFADEPTGNLDRQTgDKI--ADLLFSLnREHGTTLILVTHDLQLAARCDRRLRLVNGQLQE 226
|
|
| PRK11264 |
PRK11264 |
putative amino-acid ABC transporter ATP-binding protein YecC; Provisional |
345-532 |
1.12e-08 |
|
putative amino-acid ABC transporter ATP-binding protein YecC; Provisional
Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 55.91 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHI-VLDGVAQTAADMPDYRRLFSA-------IFTDFHQF---- 412
Cdd:PRK11264 22 IDLEVKPGEVVAIIGPSGSGKTTLLRCINLLEQPEAGTIrVGDITIDTARSLSQQKGLIRQlrqhvgfVFQNFNLFphrt 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 ---DRLQGPE--GGEPDTALVAHWLERLnmkSKLQFDGARVTNPQ-LSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:PRK11264 102 vleNIIEGPVivKGEPKEEATARARELL---AKVGLAGKETSYPRrLSGGQQQRVAIARALAMRPEVILFDEPTSALDPE 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 487 frriFYRELLPALRALG---KTVFAISHDDHYF-EHADRLLEMRSGHLRE 532
Cdd:PRK11264 179 ----LVGEVLNTIRQLAqekRTMVIVTHEMSFArDVADRAIFMDQGRIVE 224
|
|
| ABC_RNaseL_inhibitor_domain2 |
cd03237 |
The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ... |
348-523 |
1.72e-08 |
|
The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.
Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 55.49 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 348 TLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVaqTAADMPDY---------RRLFSAIFTDFH---QF--- 412
Cdd:cd03237 21 SISESEVIGILGPNGIGKTTFIKMLAGVLKPDEGDIEIELD--TVSYKPQYikadyegtvRDLLSSITKDFYthpYFkte 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 --DRLQgpeggepdtalvahwLERLnMKSKLqfdgarvtnPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFR-- 488
Cdd:cd03237 99 iaKPLQ---------------IEQI-LDREV---------PELSGGELQRVAIAACLSKDADIYLLDEPSAYLDVEQRlm 153
|
170 180 190
....*....|....*....|....*....|....*...
gi 612265813 489 --RIFYRELLPAlralGKTVFAISHDDHYFEH-ADRLL 523
Cdd:cd03237 154 asKVIRRFAENN----EKTAFVVEHDIIMIDYlADRLI 187
|
|
| PRK15056 |
PRK15056 |
manganese/iron ABC transporter ATP-binding protein; |
336-512 |
2.07e-08 |
|
manganese/iron ABC transporter ATP-binding protein;
Pssm-ID: 185016 [Multi-domain] Cd Length: 272 Bit Score: 55.66 E-value: 2.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 336 QQPGFTVGPLNLTLR--------------RGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA-------QTAAD 394
Cdd:PRK15056 3 QQAGIVVNDVTVTWRnghtalrdasftvpGGSIAALVGVNGSGKSTLFKALMGFVRLASGKISILGQPtrqalqkNLVAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 395 MPDYRRL---FSAIFTDFHQFDR------LQGPEggEPDTALVAHWLERLNMkskLQFDGARVTnpQLSQGQRKRLALLL 465
Cdd:PRK15056 83 VPQSEEVdwsFPVLVEDVVMMGRyghmgwLRRAK--KRDRQIVTAALARVDM---VEFRHRQIG--ELSGGQKKRVFLAR 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 612265813 466 AVAEQRDILLLDEWAADQDPQFR-RIFyrELLPALRALGKTVFAISHD 512
Cdd:PRK15056 156 AIAQQGQVILLDEPFTGVDVKTEaRII--SLLRELRDEGKTMLVSTHN 201
|
|
| PLN03130 |
PLN03130 |
ABC transporter C family member; Provisional |
233-532 |
2.16e-08 |
|
ABC transporter C family member; Provisional
Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 57.44 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 233 LSALNwsnIMMLGAIGLV-----FFMANSLGwADSTVAATYSLTLLF--LRTPLLQavgaFPTL----VGAEVAFNKLKA 301
Cdd:PLN03130 522 LSAFN---SFILNSIPVLvtvvsFGVFTLLG-GDLTPARAFTSLSLFavLRFPLFM----LPNLitqaVNANVSLKRLEE 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 302 LRLAE---------YQSGFPAavgrswqtLELRDVVFHYADAEQQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLL 372
Cdd:PLN03130 594 LLLAEervllpnppLEPGLPA--------ISIKNGYFSWDSKAERP--TLSNINLDVPVGSLVAIVGSTGEGKTSLISAM 663
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 373 TGLYRPVS-GHIVLDGvaqTAADMPDYRRLFSAIFTDFHQFDRLQGPEGGEP--DTALVAHWLERLNMKSKLQFdGARVT 449
Cdd:PLN03130 664 LGELPPRSdASVVIRG---TVAYVPQVSWIFNATVRDNILFGSPFDPERYERaiDVTALQHDLDLLPGGDLTEI-GERGV 739
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 450 NpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQF-RRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:PLN03130 740 N--ISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVgRQVFDKCIKDELR--GKTRVLVTNQLHFLSQVDRIILVHEG 815
|
....
gi 612265813 529 HLRE 532
Cdd:PLN03130 816 MIKE 819
|
|
| tauB |
PRK11248 |
taurine ABC transporter ATP-binding subunit; |
345-512 |
2.31e-08 |
|
taurine ABC transporter ATP-binding subunit;
Pssm-ID: 183056 [Multi-domain] Cd Length: 255 Bit Score: 55.09 E-value: 2.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA------------QTAADMPDYRRLFSAIFTdfhqf 412
Cdd:PRK11248 20 INLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSITLDGKPvegpgaergvvfQNEGLLPWRNVQDNVAFG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 drLQGPEGGEPDTALVAHwlerlNMKSKLQFDGARVTNP-QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDpQFRRIF 491
Cdd:PRK11248 95 --LQLAGVEKMQRLEIAH-----QMLKKVGLEGAEKRYIwQLSGGQRQRVGIARALAANPQLLLLDEPFGALD-AFTREQ 166
|
170 180
....*....|....*....|..
gi 612265813 492 YRELLPAL-RALGKTVFAISHD 512
Cdd:PRK11248 167 MQTLLLKLwQETGKQVLLITHD 188
|
|
| metN |
PRK11153 |
DL-methionine transporter ATP-binding subunit; Provisional |
344-511 |
3.62e-08 |
|
DL-methionine transporter ATP-binding subunit; Provisional
Pssm-ID: 236863 [Multi-domain] Cd Length: 343 Bit Score: 55.58 E-value: 3.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 344 PLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFDRLQGpeggep 423
Cdd:PRK11153 23 NVSLHIPAGEIFGVIGASGAGKSTLIRCINLLERPTSGRVLVDGQDLTALSEKELRKARRQIGMIFQHFNLLSS------ 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 424 DTAL--VAHWLErLNMKSKLQFDgARVTN--------------P-QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:PRK11153 97 RTVFdnVALPLE-LAGTPKAEIK-ARVTEllelvglsdkadryPaQLSGGQKQRVAIARALASNPKVLLCDEATSALDPA 174
|
170 180
....*....|....*....|....*..
gi 612265813 487 -FRRIFyrELLPAL-RALGKTVFAISH 511
Cdd:PRK11153 175 tTRSIL--ELLKDInRELGLTIVLITH 199
|
|
| cbiO |
PRK13645 |
energy-coupling factor transporter ATPase; |
331-528 |
5.05e-08 |
|
energy-coupling factor transporter ATPase;
Pssm-ID: 184204 [Multi-domain] Cd Length: 289 Bit Score: 54.63 E-value: 5.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 331 YADAEQQPgFTVGPLN---LTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAA-----DMPDYRRLF 402
Cdd:PRK13645 14 YTYAKKTP-FEFKALNntsLTFKKNKVTCVIGTTGSGKSTMIQLTNGLIISETGQTIVGDYAIPANlkkikEVKRLRKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFtDFHQFDRLQ---------GP-EGGEPDTALVAHWLERLNMKSkLQFDGARVTNPQLSQGQRKRLALLLAVAEQRD 472
Cdd:PRK13645 93 GLVF-QFPEYQLFQetiekdiafGPvNLGENKQEAYKKVPELLKLVQ-LPEDYVKRSPFELSGGQKRRVALAGIIAMDGN 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 473 ILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:PRK13645 171 TLVLDEPTGGLDPKGEEDFINLFERLNKEYKKRIIMVTHNmDQVLRIADEVIVMHEG 227
|
|
| cbiO |
PRK13634 |
cobalt transporter ATP-binding subunit; Provisional |
346-539 |
5.16e-08 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 54.64 E-value: 5.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAA----DMPDYRRLFSAIFtdfhQFDRLQ----- 416
Cdd:PRK13634 27 NVSIPSGSYVAIIGHTGSGKSTLLQHLNGLLQPTSGTVTIGERVITAGkknkKLKPLRKKVGIVF----QFPEHQlfeet 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 417 -------GPEG-GEPDT---ALVAHWLERLNMKSKL----QFDgarvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAA 481
Cdd:PRK13634 103 vekdicfGPMNfGVSEEdakQKAREMIELVGLPEELlarsPFE--------LSGGQMRRVAIAGVLAMEPEVLVLDEPTA 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 482 DQDPQFRR----IFYRellpALRALGKTVFAISH--DD--HYfehADRLLEMRSGHLReLTGSERE 539
Cdd:PRK13634 175 GLDPKGRKemmeMFYK----LHKEKGLTTVLVTHsmEDaaRY---ADQIVVMHKGTVF-LQGTPRE 232
|
|
| ABC_ABC_ChvD |
TIGR03719 |
ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ... |
345-512 |
7.88e-08 |
|
ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of the ABC transporter ATP-binding cassette, but are found outside the common ABC transporter operon structure that features integral membrane permease proteins and substrate-binding proteins encoded next to the ATP-binding cassette (ABC domain) protein. The member protein ChvD from Agrobacterium tumefaciens was identified as both a candidate to interact with VirB8, based on yeast two-hybrid analysis, and as an apparent regulator of VirG. The general function of this protein family is unknown.
Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 54.94 E-value: 7.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIV------LDGVAQTAADMPDYRRLFSAIfTDFHQFDRLQGP 418
Cdd:TIGR03719 341 LSFKLPPGGIVGVIGPNGAGKSTLFRMITGQEQPDSGTIEigetvkLAYVDQSRDALDPNKTVWEEI-SGGLDIIKLGKR 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 419 EggEPDTALVAhwleRLNMKSKLQfdGARVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQfrriFYRELLPA 498
Cdd:TIGR03719 420 E--IPSRAYVG----RFNFKGSDQ--QKKVG--QLSGGERNRVHLAKTLKSGGNVLLLDEPTNDLDVE----TLRALEEA 485
|
170
....*....|....
gi 612265813 499 LRALGKTVFAISHD 512
Cdd:TIGR03719 486 LLNFAGCAVVISHD 499
|
|
| PRK15112 |
PRK15112 |
peptide ABC transporter ATP-binding protein SapF; |
342-488 |
1.08e-07 |
|
peptide ABC transporter ATP-binding protein SapF;
Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 53.25 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDfhqfdrlqgpegg 421
Cdd:PRK15112 29 VKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLIDDHPLHFGDYSYRSQRIRMIFQD------------- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 422 ePDTAL-----VAHWLE---RLNMKSK----------------LQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLD 477
Cdd:PRK15112 96 -PSTSLnprqrISQILDfplRLNTDLEpeqrekqiietlrqvgLLPDHASYYPHMLAPGQKQRLGLARALILRPKVIIAD 174
|
170
....*....|.
gi 612265813 478 EWAADQDPQFR 488
Cdd:PRK15112 175 EALASLDMSMR 185
|
|
| YejF |
COG4172 |
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ... |
322-478 |
1.58e-07 |
|
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 53.92 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYAdaeQQPGF---TVGPL------NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYrPVSGHIVLDG---VA 389
Cdd:COG4172 276 LEARDLKVWFP---IKRGLfrrTVGHVkavdgvSLTLRRGETLGLVGESGSGKSTLGLALLRLI-PSEGEIRFDGqdlDG 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 390 QTAADMPDYRRLFSAIFTD-FHQFD-------------RLQGPEGGEPD-TALVAHWLERLNMKSklqfdGARVTNP-QL 453
Cdd:COG4172 352 LSRRALRPLRRRMQVVFQDpFGSLSprmtvgqiiaeglRVHGPGLSAAErRARVAEALEEVGLDP-----AARHRYPhEF 426
|
170 180
....*....|....*....|....*
gi 612265813 454 SQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:COG4172 427 SGGQRQRIAIARALILEPKLLVLDE 451
|
|
| AbcC |
COG1135 |
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; |
346-478 |
1.91e-07 |
|
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];
Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 53.16 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGV---AQTAADMPDYRRLFSAIFTDFHQFDRLqgpegge 422
Cdd:COG1135 25 SLTIEKGEIFGIIGYSGAGKSTLIRCINLLERPTSGSVLVDGVdltALSERELRAARRKIGMIFQHFNLLSSR------- 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 612265813 423 pdTAL--VAHWLERLNM-KSKLQfdgARVTN--------------P-QLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:COG1135 98 --TVAenVALPLEIAGVpKAEIR---KRVAEllelvglsdkadayPsQLSGGQKQRVGIARALANNPKVLLCDE 166
|
|
| PRK15439 |
PRK15439 |
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional |
322-530 |
1.96e-07 |
|
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional
Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 53.52 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADmPdyrrl 401
Cdd:PRK15439 12 LCARSISKQYSGVEVLKG-----IDFTLHAGEVHALLGGNGAGKSTLMKIIAGIVPPDSGTLEIGGNPCARLT-P----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 fsaifTDFHQFDRLQGPEggEPdtalvaHWLERLNMKSKLQFDGARvtnpqlSQGQRKRLALLLA--------------- 466
Cdd:PRK15439 81 -----AKAHQLGIYLVPQ--EP------LLFPNLSVKENILFGLPK------RQASMQKMKQLLAalgcqldldssagsl 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 467 -VAEQ----------RD--ILLLDEWAADQDP-QFRRIFYRelLPALRALGKTVFAISHDDH-YFEHADRLLEMRSGHL 530
Cdd:PRK15439 142 eVADRqiveilrglmRDsrILILDEPTASLTPaETERLFSR--IRELLAQGVGIVFISHKLPeIRQLADRISVMRDGTI 218
|
|
| ABCC_SUR2 |
cd03288 |
ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ... |
345-546 |
2.34e-07 |
|
ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.
Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 52.22 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTD---FHQFDRLQ-GPEG 420
Cdd:cd03288 40 VKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDpilFSGSIRFNlDPEC 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 GEPDTALvahW--LERLNMKSKLQ-----FDgARVTN--PQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIF 491
Cdd:cd03288 120 KCTDDRL---WeaLEIAQLKNMVKslpggLD-AVVTEggENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENIL 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 492 YRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSEREHASRDSV 546
Cdd:cd03288 196 QKVVMTAFA--DRTVVTIAHRVSTILDADLVLVLSRGILVECDTPENLLAQEDGV 248
|
|
| MRP_assoc_pro |
TIGR00957 |
multi drug resistance-associated protein (MRP); This model describes multi drug ... |
266-544 |
2.59e-07 |
|
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]
Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 53.80 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 266 ATYSLTLL-FLRTPLLQAVGAFPTLVGAEVAFNKLKALRLAEYQSgfPAAVGR------SWQTLELRDVVFHYADAEQQp 338
Cdd:TIGR00957 576 AFVSLALFnILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE--PDSIERrtikpgEGNSITVHNATFTWARDLPP- 652
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 339 gfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG----VAQTAADMPDYRR---LFSAIFTDFHQ 411
Cdd:TIGR00957 653 --TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVHMKGsvayVPQQAWIQNDSLReniLFGKALNEKYY 730
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 412 FDRLQGpeggepdTALVAHwLERLNMKSKLQFdGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQF-RRI 490
Cdd:TIGR00957 731 QQVLEA-------CALLPD-LEILPSGDRTEI-GEKGVN--LSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVgKHI 799
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 612265813 491 FYRELLPALRALGKTVFAISHDDHYFEHADRLLEMRSGHLRELtGSEREHASRD 544
Cdd:TIGR00957 800 FEHVIGPEGVLKNKTRILVTHGISYLPQVDVIIVMSGGKISEM-GSYQELLQRD 852
|
|
| nikD |
PRK10418 |
nickel transporter ATP-binding protein NikD; Provisional |
320-512 |
4.60e-07 |
|
nickel transporter ATP-binding protein NikD; Provisional
Pssm-ID: 236688 [Multi-domain] Cd Length: 254 Bit Score: 51.24 E-value: 4.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 QTLELRDVVFhyadaeQQPGFTVGPLNLTLRRGELVFLIGGNGSGKS-----TLAMLLTGLyRPVSGHIVLDGVAQTAAD 394
Cdd:PRK10418 3 QQIELRNIAL------QAAQPLVHGVSLTLQRGRVLALVGGSGSGKSltcaaALGILPAGV-RQTAGRVLLDGKPVAPCA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 395 ---------MPDYRRLFSAIFT-DFHQFDRLQGpEGGEPDTALVAHWLERLNMKsklqfDGARVTNP---QLSQGQRKRL 461
Cdd:PRK10418 76 lrgrkiatiMQNPRSAFNPLHTmHTHARETCLA-LGKPADDATLTAALEAVGLE-----NAARVLKLypfEMSGGMLQRM 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612265813 462 ALLLAVAEQRDILLLDEWAADQD--PQFRRIFYRELLPALRALGktVFAISHD 512
Cdd:PRK10418 150 MIALALLCEAPFIIADEPTTDLDvvAQARILDLLESIVQKRALG--MLLVTHD 200
|
|
| PRK11174 |
PRK11174 |
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
342-530 |
4.84e-07 |
|
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed
Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 52.54 E-value: 4.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGlYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTD---FHQFDR---- 414
Cdd:PRK11174 366 AGPLNFTLPAGQRIALVGPSGAGKTSLLNALLG-FLPYQGSLKINGIELRELDPESWRKHLSWVGQNpqlPHGTLRdnvl 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 415 LQGPEGGEP--DTAL----VAHWLERLN--MKSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:PRK11174 445 LGNPDASDEqlQQALenawVSEFLPLLPqgLDTPIGDQAAG-----LSVGQAQRLALARALLQPCQLLLLDEPTASLDAH 519
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 612265813 487 FRRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:PRK11174 520 SEQLVMQALNAASR--RQTTLMVTHQLEDLAQWDQIWVMQDGQI 561
|
|
| PRK13651 |
PRK13651 |
cobalt transporter ATP-binding subunit; Provisional |
346-530 |
4.96e-07 |
|
cobalt transporter ATP-binding subunit; Provisional
Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 51.63 E-value: 4.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVL---DGVAQTAADMP---------------------DYRRL 401
Cdd:PRK13651 27 SVEINQGEFIAIIGQTGSGKTTFIEHLNALLLPDTGTIEWifkDEKNKKKTKEKekvleklviqktrfkkikkikEIRRR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 FSAIFtdfhQFDRLQ------------GPE--GGEPDTA--LVAHWLERLNM-KSKLQfdgarvTNP-QLSQGQRKRLAL 463
Cdd:PRK13651 107 VGVVF----QFAEYQlfeqtiekdiifGPVsmGVSKEEAkkRAAKYIELVGLdESYLQ------RSPfELSGGQKRRVAL 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 464 LLAVAEQRDILLLDEWAADQDPQ-FRRIFyrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK13651 177 AGILAMEPDFLVFDEPTAGLDPQgVKEIL--EIFDNLNKQGKTIILVTHDlDNVLEWTKRTIFFKDGKI 243
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
351-527 |
5.65e-07 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 49.29 E-value: 5.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 351 RGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLdgvaqtaADMPDYRRlfsaiftdfhqfdrlqgpeggepdtalvah 430
Cdd:smart00382 1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIY-------IDGEDILE------------------------------ 43
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 431 wlerlNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRR-----IFYRELLPALRALGKT 505
Cdd:smart00382 44 -----EVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILDEITSLLDAEQEAlllllEELRLLLLLKSEKNLT 118
|
170 180
....*....|....*....|..
gi 612265813 506 VFAISHDDHYFehADRLLEMRS 527
Cdd:smart00382 119 VILTTNDEKDL--GPALLRRRF 138
|
|
| PLN03232 |
PLN03232 |
ABC transporter C family member; Provisional |
309-545 |
5.95e-07 |
|
ABC transporter C family member; Provisional
Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 52.67 E-value: 5.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 309 SGFPaavgrSWQTLELRDVVFHYadaeqQPGF--TVGPLNLTLRRGELVFLIGGNGSGKSTlamLLTGLYRPVS---GHI 383
Cdd:PLN03232 1227 SGWP-----SRGSIKFEDVHLRY-----RPGLppVLHGLSFFVSPSEKVGVVGRTGAGKSS---MLNALFRIVElekGRI 1293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 384 VLDGVAQTAADMPDYRRLFSAIFTD---FHQFDRLQGPEGGEPDTALVAHWLERLNMKSKLQ----------FDGARvtn 450
Cdd:PLN03232 1294 MIDDCDVAKFGLTDLRRVLSIIPQSpvlFSGTVRFNIDPFSEHNDADLWEALERAHIKDVIDrnpfgldaevSEGGE--- 1370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 451 pQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALgkTVFAISHDDHYFEHADRLLEMRSGHL 530
Cdd:PLN03232 1371 -NFSVGQRQLLSLARALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKSC--TMLVIAHRLNTIIDCDKILVLSSGQV 1447
|
250
....*....|....*
gi 612265813 531 RELTgSEREHASRDS 545
Cdd:PLN03232 1448 LEYD-SPQELLSRDT 1461
|
|
| NupO |
COG3845 |
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
290-550 |
6.84e-07 |
|
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];
Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 51.95 E-value: 6.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 290 VGAEVAFNKLKAlrlaeyqsgfPAAVGRSwqTLELRDVvfHYADAEQQPGftVGPLNLTLRRGELVFLIGGNGSGKSTLA 369
Cdd:COG3845 238 VGREVLLRVEKA----------PAEPGEV--VLEVENL--SVRDDRGVPA--LKDVSLEVRAGEILGIAGVAGNGQSELA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 370 MLLTGLYRPVSGHIVLDGVAQTAADMPDYRRL-----------------FS----AIFTDFHQ--FDRlqgpeGGEPDTA 426
Cdd:COG3845 302 EALAGLRPPASGSIRLDGEDITGLSPRERRRLgvayipedrlgrglvpdMSvaenLILGRYRRppFSR-----GGFLDRK 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 427 LVAHWLERLnMKsklQFDgARVTNPQ-----LSQG--QRkrlaLLLA--VAEQRDILL-------LDEWAADqdpqfrri 490
Cdd:COG3845 377 AIRAFAEEL-IE---EFD-VRTPGPDtparsLSGGnqQK----VILAreLSRDPKLLIaaqptrgLDVGAIE-------- 439
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 491 FYRELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGhlrELTGS-EREHASRDsvsRIG 550
Cdd:COG3845 440 FIHQRLLELRDAGAAVLLISEDlDEILALSDRIAVMYEG---RIVGEvPAAEATRE---EIG 495
|
|
| PRK09700 |
PRK09700 |
D-allose ABC transporter ATP-binding protein AlsA; |
345-389 |
1.04e-06 |
|
D-allose ABC transporter ATP-binding protein AlsA;
Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 51.32 E-value: 1.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVA 389
Cdd:PRK09700 24 VNLTVYPGEIHALLGENGAGKSTLMKVLSGIHEPTKGTITINNIN 68
|
|
| PRK10575 |
PRK10575 |
Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC; |
321-530 |
1.70e-06 |
|
Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;
Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 49.79 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 321 TLELRDVVFhyadaeQQPGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYR 399
Cdd:PRK10575 11 TFALRNVSF------RVPGRTLlHPLSLTFPAGKVTGLIGHNGSGKSTLLKMLGRHQPPSEGEILLDAQPLESWSSKAFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIFTDFHQFDRLQGPEggepdtaLVA----HW---LERLNMKSKLQFDGA-----------RVTNpQLSQGQRKRL 461
Cdd:PRK10575 85 RKVAYLPQQLPAAEGMTVRE-------LVAigryPWhgaLGRFGAADREKVEEAislvglkplahRLVD-SLSGGERQRA 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 462 ALLLAVAEQRDILLLDE--WAADQDPQFRRIFYRELLPALRALgkTVFAISHD-DHYFEHADRLLEMRSGHL 530
Cdd:PRK10575 157 WIAMLVAQDSRCLLLDEptSALDIAHQVDVLALVHRLSQERGL--TVIAVLHDiNMAARYCDYLVALRGGEM 226
|
|
| CFTR_protein |
TIGR01271 |
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
345-529 |
2.45e-06 |
|
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]
Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 50.68 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG----VAQTAADMPDYRR---LFSAIFTDFHQFDRLQG 417
Cdd:TIGR01271 445 ISFKLEKGQLLAVAGSTGSGKSSLLMMIMGELEPSEGKIKHSGrisfSPQTSWIMPGTIKdniIFGLSYDEYRYTSVIKA 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 418 PEgGEPDTALVAHwlerlnmKSKLQFDGARVTnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLP 497
Cdd:TIGR01271 525 CQ-LEEDIALFPE-------KDKTVLGEGGIT---LSGGQRARISLARAVYKDADLYLLDSPFTHLDVVTEKEIFESCLC 593
|
170 180 190
....*....|....*....|....*....|..
gi 612265813 498 ALRAlGKTVFAISHDDHYFEHADRLLEMRSGH 529
Cdd:TIGR01271 594 KLMS-NKTRILVTSKLEHLKKADKILLLHEGV 624
|
|
| COG4586 |
COG4586 |
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ... |
345-478 |
3.00e-06 |
|
ABC-type uncharacterized transport system, ATPase component [General function prediction only];
Pssm-ID: 443643 [Multi-domain] Cd Length: 323 Bit Score: 49.32 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG----------VAQTAA----------DMP--DYRRLF 402
Cdd:COG4586 41 ISFTIEPGEIVGFIGPNGAGKSTTIKMLTGILVPTSGEVRVLGyvpfkrrkefARRIGVvfgqrsqlwwDLPaiDSFRLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIF----TDFHQfdRLqgpeggepdtalvAHWLERLNMKSKLqfdgarvTNP--QLSQGQRKRLALLLAVAEQRDILLL 476
Cdd:COG4586 121 KAIYripdAEYKK--RL-------------DELVELLDLGELL-------DTPvrQLSLGQRMRCELAAALLHRPKILFL 178
|
..
gi 612265813 477 DE 478
Cdd:COG4586 179 DE 180
|
|
| PRK13549 |
PRK13549 |
xylose transporter ATP-binding subunit; Provisional |
346-528 |
3.19e-06 |
|
xylose transporter ATP-binding subunit; Provisional
Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 49.93 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYrPV---SGHIVLDGVAQTAADMPDYRRLFSAIftdFHQFDRLQgPE--- 419
Cdd:PRK13549 25 SLKVRAGEIVSLCGENGAGKSTLMKVLSGVY-PHgtyEGEIIFEGEELQASNIRDTERAGIAI---IHQELALV-KElsv 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 ------GGEPDTALVAHW----LERLNMKSKLQFD---GARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:PRK13549 100 leniflGNEITPGGIMDYdamyLRAQKLLAQLKLDinpATPVGN--LGLGQQQLVEIAKALNKQARLLILDEPTASLTES 177
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 612265813 487 FRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSG 528
Cdd:PRK13549 178 ETAVLL-DIIRDLKAHGIACIYISHKlNEVKAISDTICVIRDG 219
|
|
| ABC_UvrA |
cd03238 |
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ... |
345-537 |
3.20e-06 |
|
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.
Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 47.70 E-value: 3.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLamLLTGLYrpvsghivldgvAQTAADMPDYRRLFSAIFTDFhqFDRLQgpeggepd 424
Cdd:cd03238 14 LDVSIPLNVLVVVTGVSGSGKSTL--VNEGLY------------ASGKARLISFLPKFSRNKLIF--IDQLQ-------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 425 tALVAHWLERLNMKSKLQfdgarvtnpQLSQG--QRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRAL 502
Cdd:cd03238 70 -FLIDVGLGYLTLGQKLS---------TLSGGelQRVKLASELFSEPPGTLFILDEPSTGLHQQDINQLL-EVIKGLIDL 138
|
170 180 190
....*....|....*....|....*....|....*
gi 612265813 503 GKTVFAISHDDHYFEHADRLLEMrsGHLRELTGSE 537
Cdd:cd03238 139 GNTVILIEHNLDVLSSADWIIDF--GPGSGKSGGK 171
|
|
| araG |
PRK11288 |
L-arabinose ABC transporter ATP-binding protein AraG; |
313-546 |
3.85e-06 |
|
L-arabinose ABC transporter ATP-binding protein AraG;
Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 49.52 E-value: 3.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 313 AAVGRS------WQTLELRDVVFHyADAEQQPGFTvGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLD 386
Cdd:PRK11288 236 AMVGREigdiygYRPRPLGEVRLR-LDGLKGPGLR-EPISFSVRAGEIVGLFGLVGAGRSELMKLLYGATRRTAGQVYLD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 387 GVAQTAADMPDY-------------------------------RRLFSAIFTDFHQfdrlqgpeGGEPDTAlvAHWLERL 435
Cdd:PRK11288 314 GKPIDIRSPRDAiragimlcpedrkaegiipvhsvadninisaRRHHLRAGCLINN--------RWEAENA--DRFIRSL 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 436 NMKSKlqfdGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISHD-DH 514
Cdd:PRK11288 384 NIKTP----SREQLIMNLSGGNQQKAILGRWLSEDMKVILLDEPTRGIDVGAKHEIY-NVIYELAAQGVAVLFVSSDlPE 458
|
250 260 270
....*....|....*....|....*....|...
gi 612265813 515 YFEHADRLLEMRSGHLR-ELTgseREHASRDSV 546
Cdd:PRK11288 459 VLGVADRIVVMREGRIAgELA---REQATERQA 488
|
|
| CFTR_protein |
TIGR01271 |
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
345-495 |
4.27e-06 |
|
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]
Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 49.91 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLamlLTGLYRPVS--GHIVLDGVAQTAADMPDYRRLFSAI----FTDFHQFDRLQGP 418
Cdd:TIGR01271 1238 LSFSVEGGQRVGLLGRTGSGKSTL---LSALLRLLSteGEIQIDGVSWNSVTLQTWRKAFGVIpqkvFIFSGTFRKNLDP 1314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 419 EGGEPDTALvahW--LERLNMKS-------KLQF---DGARVtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQ 486
Cdd:TIGR01271 1315 YEQWSDEEI---WkvAEEVGLKSvieqfpdKLDFvlvDGGYV----LSNGHKQLMCLARSILSKAKILLLDEPSAHLDPV 1387
|
....*....
gi 612265813 487 FRRIFYREL 495
Cdd:TIGR01271 1388 TLQIIRKTL 1396
|
|
| Rli1 |
COG1245 |
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ... |
348-512 |
6.78e-06 |
|
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 49.01 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 348 TLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLD-GVA------QTAADMPDYRRLFSAIFTDFhqfdrlqgpeg 420
Cdd:COG1245 362 EIREGEVLGIVGPNGIGKTTFAKILAGVLKPDEGEVDEDlKISykpqyiSPDYDGTVEEFLRSANTDDF----------- 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 gePDTALVAHWLERLNMKSKLQfdgARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRellpALR 500
Cdd:COG1245 431 --GSSYYKTEIIKPLGLEKLLD---KNVKD--LSGGELQRVAIAACLSRDADLYLLDEPSAHLDVEQRLAVAK----AIR 499
|
170
....*....|....*.
gi 612265813 501 AL----GKTVFAISHD 512
Cdd:COG1245 500 RFaenrGKTAMVVDHD 515
|
|
| MglA |
COG1129 |
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; |
325-387 |
6.82e-06 |
|
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];
Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 48.86 E-value: 6.82e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 325 RDVVFHYADAEQQPG--------FTVG----PLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG 387
Cdd:COG1129 239 RELEDLFPKRAAAPGevvlevegLSVGgvvrDVSFSVRAGEILGIAGLVGAGRTELARALFGADPADSGEIRLDG 313
|
|
| PRK13409 |
PRK13409 |
ribosome biogenesis/translation initiation ATPase RLI; |
348-512 |
7.38e-06 |
|
ribosome biogenesis/translation initiation ATPase RLI;
Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 48.65 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 348 TLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDgvaQTAADMPDY---------RRLFSAIFTDFHQ------- 411
Cdd:PRK13409 361 EIYEGEVIGIVGPNGIGKTTFAKLLAGVLKPDEGEVDPE---LKISYKPQYikpdydgtvEDLLRSITDDLGSsyyksei 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 412 FDRLQgpeggepdtalvahwLERLnMKSKLqfdgarvtnPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIF 491
Cdd:PRK13409 438 IKPLQ---------------LERL-LDKNV---------KDLSGGELQRVAIAACLSRDADLYLLDEPSAHLDVEQRLAV 492
|
170 180
....*....|....*....|....*
gi 612265813 492 YRellpALRAL----GKTVFAISHD 512
Cdd:PRK13409 493 AK----AIRRIaeerEATALVVDHD 513
|
|
| tagH |
PRK13545 |
teichoic acids export protein ATP-binding subunit; Provisional |
323-532 |
8.68e-06 |
|
teichoic acids export protein ATP-binding subunit; Provisional
Pssm-ID: 184130 [Multi-domain] Cd Length: 549 Bit Score: 48.35 E-value: 8.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 323 ELRDVVFHYADAEQQpgFTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQtaadmpdyrrlF 402
Cdd:PRK13545 23 KLKDLFFRSKDGEYH--YALNNISFEVPEGEIVGIIGLNGSGKSTLSNLIAGVTMPNKGTVDIKGSAA-----------L 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 403 SAIFTDFHqfDRLQGPEGGEpdtalvahwLERLNM---KSKLQ--------FD--GARVTNP--QLSQGQRKRLALLLAV 467
Cdd:PRK13545 90 IAISSGLN--GQLTGIENIE---------LKGLMMgltKEKIKeiipeiieFAdiGKFIYQPvkTYSSGMKSRLGFAISV 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612265813 468 AEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISHD-DHYFEHADRLLEMRSGHLRE 532
Cdd:PRK13545 159 HINPDILVIDEALSVGDQTFTKKCL-DKMNEFKEQGKTIFFISHSlSQVKSFCTKALWLHYGQVKE 223
|
|
| ABC_CcmA_heme_exporter |
cd03231 |
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
345-478 |
8.96e-06 |
|
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.
Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 46.72 E-value: 8.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQT------------AADMPDYRRLFSAI-----FT 407
Cdd:cd03231 19 LSFTLAAGEALQVTGPNGSGKTTLLRILAGLSPPLAGRVLLNGGPLDfqrdsiargllyLGHAPGIKTTLSVLenlrfWH 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 408 DFHqfdrlqgpeggepDTALVAHWLERLNMKSklqFDGARVTnpQLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:cd03231 99 ADH-------------SDEQVEEALARVGLNG---FEDRPVA--QLSAGQQRRVALARLLLSGRPLWILDE 151
|
|
| araG |
PRK11288 |
L-arabinose ABC transporter ATP-binding protein AraG; |
347-390 |
9.84e-06 |
|
L-arabinose ABC transporter ATP-binding protein AraG;
Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 48.37 E-value: 9.84e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 612265813 347 LTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQ 390
Cdd:PRK11288 25 FDCRAGQVHALMGENGAGKSTLLKILSGNYQPDAGSILIDGQEM 68
|
|
| xylG |
TIGR02633 |
D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ... |
322-511 |
1.23e-05 |
|
D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose isomerase and xylulokinase enzymes for xylose utilization. Members of this protein family are the ATP-binding cassette (ABC) subunit of the known or predicted high-affinity xylose ABC transporter for xylose import. These genes, which closely resemble other sugar transport ABC transporter genes, typically are encoded near xylose utilization enzymes and regulatory proteins. Note that this form of the transporter contains two copies of the ABC transporter domain (pfam00005). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 47.90 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAEQQPGftvgpLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYR--PVSGHIVLDGVAQTAADMPDYR 399
Cdd:TIGR02633 2 LEMKGIVKTFGGVKALDG-----IDLEVRPGECVGLCGENGAGKSTLMKILSGVYPhgTWDGEIYWSGSPLKASNIRDTE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 400 RLFSAIftdFHQFDRL-----------QGPE----GGEPDTALVAHWLErlNMKSKLQFDGARVTNP--QLSQGQRKRLA 462
Cdd:TIGR02633 77 RAGIVI---IHQELTLvpelsvaenifLGNEitlpGGRMAYNAMYLRAK--NLLRELQLDADNVTRPvgDYGGGQQQLVE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALRALGKTVFAISH 511
Cdd:TIGR02633 152 IAKALNKQARLLILDEPSSSLTEKETEILL-DIIRDLKAHGVACVYISH 199
|
|
| rim_protein |
TIGR01257 |
retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ... |
342-511 |
1.57e-05 |
|
retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]
Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 48.09 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYR------PVSGHIVLDGVAQTAADMpDYRRLFSAI------FTDF 409
Cdd:TIGR01257 1955 VDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTvtsgdaTVAGKSILTNISDVHQNM-GYCPQFDAIddlltgREHL 2033
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 410 HQFDRLQGPEGGEPDTalVAHWlerlnmksKLQFDGARVTNPQL----SQGQRKRLALLLAVAEQRDILLLDEWAADQDP 485
Cdd:TIGR01257 2034 YLYARLRGVPAEEIEK--VANW--------SIQSLGLSLYADRLagtySGGNKRKLSTAIALIGCPPLVLLDEPTTGMDP 2103
|
170 180
....*....|....*....|....*.
gi 612265813 486 QFRRIFYRELLPALRAlGKTVFAISH 511
Cdd:TIGR01257 2104 QARRMLWNTIVSIIRE-GRAVVLTSH 2128
|
|
| PRK15134 |
PRK15134 |
microcin C ABC transporter ATP-binding protein YejF; Provisional |
302-514 |
1.78e-05 |
|
microcin C ABC transporter ATP-binding protein YejF; Provisional
Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 47.39 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 302 LRLAEYQSGFPAAVGrswqtLELRDVVFHYAdaeqqpgftVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPvSG 381
Cdd:PRK15134 276 LDVEQLQVAFPIRKG-----ILKRTVDHNVV---------VKNISFTLRPGETLGLVGESGSGKSTTGLALLRLINS-QG 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 382 HIVLDGVA---QTAADMPDYRRLFSAIFTDfhqfdrlqgpeggePDTALVAhwleRLNMKSKLQfDGARVTNPQL----- 453
Cdd:PRK15134 341 EIWFDGQPlhnLNRRQLLPVRHRIQVVFQD--------------PNSSLNP----RLNVLQIIE-EGLRVHQPTLsaaqr 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 454 -------------------------SQGQRKRLALLLAVAEQRDILLLDEWAADQDpqfrRIFYRELLPALRALGKT--- 505
Cdd:PRK15134 402 eqqviavmeevgldpetrhrypaefSGGQRQRIAIARALILKPSLIILDEPTSSLD----KTVQAQILALLKSLQQKhql 477
|
250
....*....|.
gi 612265813 506 --VFaISHDDH 514
Cdd:PRK15134 478 ayLF-ISHDLH 487
|
|
| ABC_ABC_ChvD |
TIGR03719 |
ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ... |
357-529 |
1.95e-05 |
|
ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of the ABC transporter ATP-binding cassette, but are found outside the common ABC transporter operon structure that features integral membrane permease proteins and substrate-binding proteins encoded next to the ATP-binding cassette (ABC domain) protein. The member protein ChvD from Agrobacterium tumefaciens was identified as both a candidate to interact with VirB8, based on yeast two-hybrid analysis, and as an apparent regulator of VirG. The general function of this protein family is unknown.
Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 47.24 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 357 LIGGNGSGKSTLAMLLTGLYRPVSGH--------------------------IVLDGVAQTAADMPDYRRLFSAIFTDFH 410
Cdd:TIGR03719 36 VLGLNGAGKSTLLRIMAGVDKDFNGEarpqpgikvgylpqepqldptktvreNVEEGVAEIKDALDRFNEISAKYAEPDA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 411 QFDRLqGPEGGEPDTALVAH--WlerlNMKSKLQF---------DGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDE- 478
Cdd:TIGR03719 116 DFDKL-AAEQAELQEIIDAAdaW----DLDSQLEIamdalrcppWDADVTK--LSGGERRRVALCRLLLSKPDMLLLDEp 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 479 ----------WaadqdpqfrrifyreLLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGH 529
Cdd:TIGR03719 189 tnhldaesvaW---------------LERHLQEYPGTVVAVTHDRYFLDNvAGWILELDRGR 235
|
|
| ABCC_CFTR2 |
cd03289 |
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ... |
322-495 |
1.97e-05 |
|
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.
Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 46.39 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADAeqqpGFTV-GPLNLTLRRGELVFLIGGNGSGKSTLamlLTGLYRPVS--GHIVLDGVAQTAADMPDY 398
Cdd:cd03289 3 MTVKDLTAKYTEG----GNAVlENISFSISPGQRVGLLGRTGSGKSTL---LSAFLRLLNteGDIQIDGVSWNSVPLQKW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 399 RRLFSAI----FTDFHQFDRLQGPEGGEPDTAL--VAhwlERLNMKS-------KLQF---DGARVtnpqLSQGQRKRLA 462
Cdd:cd03289 76 RKAFGVIpqkvFIFSGTFRKNLDPYGKWSDEEIwkVA---EEVGLKSvieqfpgQLDFvlvDGGCV----LSHGHKQLMC 148
|
170 180 190
....*....|....*....|....*....|...
gi 612265813 463 LLLAVAEQRDILLLDEWAADQDPQFRRIFYREL 495
Cdd:cd03289 149 LARSVLSKAKILLLDEPSAHLDPITYQVIRKTL 181
|
|
| PRK10790 |
PRK10790 |
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; |
321-387 |
2.02e-05 |
|
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;
Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 47.41 E-value: 2.02e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 321 TLELRDVVFHYADAEQqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG 387
Cdd:PRK10790 340 RIDIDNVSFAYRDDNL----VLQNINLSVPSRGFVALVGHTGSGKSTLASLLMGYYPLTEGEIRLDG 402
|
|
| ATM1 |
COG5265 |
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ... |
321-387 |
3.45e-05 |
|
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 46.74 E-value: 3.45e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 321 TLELRDVVFHYaDAEQQ----PGFTVGPlnltlrrGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG 387
Cdd:COG5265 357 EVRFENVSFGY-DPERPilkgVSFEVPA-------GKTVAIVGPSGAGKSTLARLLFRFYDVTSGRILIDG 419
|
|
| PTZ00243 |
PTZ00243 |
ABC transporter; Provisional |
352-546 |
3.92e-05 |
|
ABC transporter; Provisional
Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 46.70 E-value: 3.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 352 GELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFHQFD---RLQGPEGGEPDTALV 428
Cdd:PTZ00243 1336 REKVGIVGRTGSGKSTLLLTFMRMVEVCGGEIRVNGREIGAYGLRELRRQFSMIPQDPVLFDgtvRQNVDPFLEASSAEV 1415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 429 AHWLERLNMKSKLQFDG----ARVTN--PQLSQGQRKRLALLLAVAEQ-RDILLLDEWAADQDPQFRRIFYRELLPALRA 501
Cdd:PTZ00243 1416 WAALELVGLRERVASESegidSRVLEggSNYSVGQRQLMCMARALLKKgSGFILMDEATANIDPALDRQIQATVMSAFSA 1495
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 612265813 502 LgkTVFAISHDDHYFEHADRLLEMRSGHLRELtGSEREHA-SRDSV 546
Cdd:PTZ00243 1496 Y--TVITIAHRLHTVAQYDKIIVMDHGAVAEM-GSPRELVmNRQSI 1538
|
|
| znuC |
PRK09544 |
high-affinity zinc transporter ATPase; Reviewed |
345-514 |
4.50e-05 |
|
high-affinity zinc transporter ATPase; Reviewed
Pssm-ID: 181939 [Multi-domain] Cd Length: 251 Bit Score: 45.10 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAdMPDYRRLFSAIFTDFHQFDRLQGpeGGEPD 424
Cdd:PRK09544 23 VSLELKPGKILTLLGPNGAGKSTLVRVVLGLVAPDEGVIKRNGKLRIGY-VPQKLYLDTTLPLTVNRFLRLRP--GTKKE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 425 TALVAhwLERLNMKSKLQFDGARvtnpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYrELLPALR-ALG 503
Cdd:PRK09544 100 DILPA--LKRVQAGHLIDAPMQK-----LSGGETQRVLLARALLNRPQLLVLDEPTQGVDVNGQVALY-DLIDQLRrELD 171
|
170
....*....|.
gi 612265813 504 KTVFAISHDDH 514
Cdd:PRK09544 172 CAVLMVSHDLH 182
|
|
| ABCG_White |
cd03234 |
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ... |
345-478 |
4.91e-05 |
|
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners.
Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 44.95 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRP---VSGHIVLDGVAQTAADMPD---YRR---------------LFS 403
Cdd:cd03234 26 VSLHVESGQVMAILGSSGSGKTTLLDAISGRVEGggtTSGQILFNGQPRKPDQFQKcvaYVRqddillpgltvretlTYT 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 612265813 404 AIFtdfhqfdRLQGPEGGEPDTALVAhwLERLNMKSKLQFDGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:cd03234 106 AIL-------RLPRKSSDAIRKKRVE--DVLLRDLALTRIGGNLVKG--ISGGERRRVSIAVQLLWDPKVLILDE 169
|
|
| ABCC_SUR1_N |
cd03290 |
ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ... |
341-528 |
5.62e-05 |
|
ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.
Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 44.63 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 341 TVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRR-------------------- 400
Cdd:cd03290 16 TLSNINIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNKNESEPSFEATRSrnrysvayaaqkpwllnatv 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 401 ----LFSAIFTDfHQFDRLQGPEGGEPDTALVAHwlerlnmKSKLQFdGARVTNpqLSQGQRKRLALLLAVAEQRDILLL 476
Cdd:cd03290 96 eeniTFGSPFNK-QRYKAVTDACSLQPDIDLLPF-------GDQTEI-GERGIN--LSGGQRQRICVARALYQNTNIVFL 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612265813 477 DEWAADQDPQFRRIFYRE-LLPALRALGKTVFAISHDDHYFEHADRLLEMRSG 528
Cdd:cd03290 165 DDPFSALDIHLSDHLMQEgILKFLQDDKRTLVLVTHKLQYLPHADWIIAMKDG 217
|
|
| ABCC_CFTR1 |
cd03291 |
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ... |
345-477 |
6.04e-05 |
|
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.
Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 45.23 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG----VAQTAADMPDYRR---LFSAIFTDFHQFDRLQG 417
Cdd:cd03291 56 INLKIEKGEMLAITGSTGSGKTSLLMLILGELEPSEGKIKHSGrisfSSQFSWIMPGTIKeniIFGVSYDEYRYKSVVKA 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 418 PEGGEPdtalvahwLERLNMKSKLQFDGARVTnpqLSQGQRKRLALLLAVAEQRDILLLD 477
Cdd:cd03291 136 CQLEED--------ITKFPEKDNTVLGEGGIT---LSGGQRARISLARAVYKDADLYLLD 184
|
|
| PRK13540 |
PRK13540 |
cytochrome c biogenesis protein CcmA; Provisional |
322-520 |
6.24e-05 |
|
cytochrome c biogenesis protein CcmA; Provisional
Pssm-ID: 184127 [Multi-domain] Cd Length: 200 Bit Score: 44.17 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHYADaeqQPgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvAQTAADMPDYRRl 401
Cdd:PRK13540 2 LDVIELDFDYHD---QP--LLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFER-QSIKKDLCTYQK- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 402 fsaiftdfhQFDRLQGPEGGEPDTALVAHWLERLNMKS-KLQFD--------GARVTNP--QLSQGQRKRLALLLAVAEQ 470
Cdd:PRK13540 75 ---------QLCFVGHRSGINPYLTLRENCLYDIHFSPgAVGITelcrlfslEHLIDYPcgLLSSGQKRQVALLRLWMSK 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 471 RDILLLDEWAADQDPQFRRIFYRElLPALRALGKTVFAISHDDHYFEHAD 520
Cdd:PRK13540 146 AKLWLLDEPLVALDELSLLTIITK-IQEHRAKGGAVLLTSHQDLPLNKAD 194
|
|
| YejF |
COG4172 |
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ... |
322-532 |
6.61e-05 |
|
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 45.45 E-value: 6.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRD--VVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAM----LLTGLYRPVSGHIVLDGVAQTAADM 395
Cdd:COG4172 7 LSVEDlsVAFGQGGGTVE---AVKGVSFDIAAGETLALVGESGSGKSVTALsilrLLPDPAAHPSGSILFDGQDLLGLSE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 PDYRRL----FSAIFtdfhQfdrlqgpeggEPDTAL---------VAhwlERLNMKSKLQFDGAR-----------VTNP 451
Cdd:COG4172 84 RELRRIrgnrIAMIF----Q----------EPMTSLnplhtigkqIA---EVLRLHRGLSGAAARaralellervgIPDP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 452 ---------QLSQGQRKRLALLLAVAEQRDILLLDE--WAADQDPQfRRIFyrELLPALRA-LGKTVFAISHDDHYFEH- 518
Cdd:COG4172 147 errldayphQLSGGQRQRVMIAMALANEPDLLIADEptTALDVTVQ-AQIL--DLLKDLQReLGMALLLITHDLGVVRRf 223
|
250
....*....|....
gi 612265813 519 ADRLLEMRSGHLRE 532
Cdd:COG4172 224 ADRVAVMRQGEIVE 237
|
|
| dppF |
PRK11308 |
dipeptide transporter ATP-binding subunit; Provisional |
348-533 |
7.31e-05 |
|
dipeptide transporter ATP-binding subunit; Provisional
Pssm-ID: 236898 [Multi-domain] Cd Length: 327 Bit Score: 44.96 E-value: 7.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 348 TLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAADMPDYRRLFSAIFTDFhqfdrlQGPEG------- 420
Cdd:PRK11308 37 TLERGKTLAVVGESGCGKSTLARLLTMIETPTGGELYYQGQDLLKADPEAQKLLRQKIQIVF------QNPYGslnprkk 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 -----GEP---DTALVAHwlERlnmKSKLQFDGARV-TNPQ--------LSQGQRKRLALLLAVAEQRDILLLDEWAADQ 483
Cdd:PRK11308 111 vgqilEEPlliNTSLSAA--ER---REKALAMMAKVgLRPEhydryphmFSGGQRQRIAIARALMLDPDVVVADEPVSAL 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 612265813 484 DPQFRRIFYRELLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHLREL 533
Cdd:PRK11308 186 DVSVQAQVLNLMMDLQQELGLSYVFISHDLSVVEHiADEVMVMYLGRCVEK 236
|
|
| PRK11819 |
PRK11819 |
putative ABC transporter ATP-binding protein; Reviewed |
345-512 |
1.19e-04 |
|
putative ABC transporter ATP-binding protein; Reviewed
Pssm-ID: 236992 [Multi-domain] Cd Length: 556 Bit Score: 44.72 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLdG-------VAQTAADMPDYRRLFSAIfTDFHQFDRLQG 417
Cdd:PRK11819 343 LSFSLPPGGIVGIIGPNGAGKSTLFKMITGQEQPDSGTIKI-GetvklayVDQSRDALDPNKTVWEEI-SGGLDIIKVGN 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 418 PEggEPDTALVAhwleRLNmksklqFDGA----RVTnpQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQfrriFYR 493
Cdd:PRK11819 421 RE--IPSRAYVG----RFN------FKGGdqqkKVG--VLSGGERNRLHLAKTLKQGGNVLLLDEPTNDLDVE----TLR 482
|
170
....*....|....*....
gi 612265813 494 ELLPALRALGKTVFAISHD 512
Cdd:PRK11819 483 ALEEALLEFPGCAVVISHD 501
|
|
| PRK10261 |
PRK10261 |
glutathione transporter ATP-binding protein; Provisional |
352-512 |
1.25e-04 |
|
glutathione transporter ATP-binding protein; Provisional
Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 44.85 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 352 GELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDY-----RRLFSAIFTD-FHQFD------------ 413
Cdd:PRK10261 350 GETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNG--QRIDTLSPGklqalRRDIQFIFQDpYASLDprqtvgdsimep 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 414 -RLQGPEGGEPDTALVAHWLERLNMKSklqfDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFY 492
Cdd:PRK10261 428 lRVHGLLPGKAAAARVAWLLERVGLLP----EHAWRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSIRGQII 503
|
170 180
....*....|....*....|
gi 612265813 493 RELLPALRALGKTVFAISHD 512
Cdd:PRK10261 504 NLLLDLQRDFGIAYLFISHD 523
|
|
| ABC_6TM_LmrA_like |
cd18551 |
Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar ... |
15-150 |
2.10e-04 |
|
Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins; This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.
Pssm-ID: 349995 [Multi-domain] Cd Length: 289 Bit Score: 43.19 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 15 FLAVMALTMASAGLGIGIIAFINQYLMDVSGNPLAVLPMFLallallIAVTLGSQLALTTLGHY--------FVYRLRGQ 86
Cdd:cd18551 1 LILALLLSLLGTAASLAQPLLVKNLIDALSAGGSSGGLLAL------LVALFLLQAVLSALSSYllgrtgerVVLDLRRR 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612265813 87 LVKRILDTEIERLEQLGSASLLASLSSD---IRN-ITIAfvrLPELVQGVILTLGAAAYLGWLSPKML 150
Cdd:cd18551 75 LWRRLLRLPVSFFDRRRSGDLVSRVTNDttlLRElITSG---LPQLVTGVLTVVGAVVLMFLLDWVLT 139
|
|
| GguA |
NF040905 |
sugar ABC transporter ATP-binding protein; |
346-387 |
2.20e-04 |
|
sugar ABC transporter ATP-binding protein;
Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 44.01 E-value: 2.20e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYrP---VSGHIVLDG 387
Cdd:NF040905 21 NLSVREGEIHALCGENGAGKSTLMKVLSGVY-PhgsYEGEILFDG 64
|
|
| PTZ00243 |
PTZ00243 |
ABC transporter; Provisional |
345-536 |
2.28e-04 |
|
ABC transporter; Provisional
Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 44.38 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVldgVAQTAADMPDYRRLFSA------IFTDFHQFDRLQGP 418
Cdd:PTZ00243 679 VSVSVPRGKLTVVLGATGSGKSTLLQSLLSQFEISEGRVW---AERSIAYVPQQAWIMNAtvrgniLFFDEEDAARLADA 755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 419 ---EGGEPDTALVAHWLErlnmkSKLqfdGARVTNpqLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQF-RRIFYRE 494
Cdd:PTZ00243 756 vrvSQLEADLAQLGGGLE-----TEI---GEKGVN--LSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVgERVVEEC 825
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 612265813 495 LLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLrELTGS 536
Cdd:PTZ00243 826 FLGALA--GKTRVLATHQVHVVPRADYVVALGDGRV-EFSGS 864
|
|
| YddA |
COG4178 |
ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
342-538 |
2.33e-04 |
|
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only];
Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 44.03 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLdgvaqtaadmPDYRRLF--------------SAIFt 407
Cdd:COG4178 379 LEDLSLSLKPGERLLITGPSGSGKSTLLRAIAGLWPYGSGRIAR----------PAGARVLflpqrpylplgtlrEALL- 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 408 dfhqfdrLQGPEGGEPDTALVA--------HWLERLNMKSklqfDGARVtnpqLSQGQRKRLA---LLLAvaeQRDILLL 476
Cdd:COG4178 448 -------YPATAEAFSDAELREaleavglgHLAERLDEEA----DWDQV----LSLGEQQRLAfarLLLH---KPDWLFL 509
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612265813 477 DEWAADQDPQFRRIFYRELLPALRalGKTVFAISHDDHYFEHADRLLEMRSGHLRELTGSER 538
Cdd:COG4178 510 DEATSALDEENEAALYQLLREELP--GTTVISVGHRSTLAAFHDRVLELTGDGSWQLLPAEA 569
|
|
| PRK10895 |
PRK10895 |
lipopolysaccharide ABC transporter ATP-binding protein; Provisional |
342-512 |
2.45e-04 |
|
lipopolysaccharide ABC transporter ATP-binding protein; Provisional
Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 42.96 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGvaQTAADMPDYRRLF---------SAIFTDFHQF 412
Cdd:PRK10895 19 VEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDD--EDISLLPLHARARrgigylpqeASIFRRLSVY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 413 DRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQ-LSQGQRKRLALLLAVAEQRDILLLDEWAADQDPqFRRIF 491
Cdd:PRK10895 97 DNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQsLSGGERRRVEIARALAANPKFILLDEPFAGVDP-ISVID 175
|
170 180
....*....|....*....|.
gi 612265813 492 YRELLPALRALGKTVFAISHD 512
Cdd:PRK10895 176 IKRIIEHLRDSGLGVLITDHN 196
|
|
| PRK15079 |
PRK15079 |
oligopeptide ABC transporter ATP-binding protein OppF; Provisional |
322-408 |
2.59e-04 |
|
oligopeptide ABC transporter ATP-binding protein OppF; Provisional
Pssm-ID: 185037 [Multi-domain] Cd Length: 331 Bit Score: 43.16 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 322 LELRDVVFHY--ADAEQ---QPGFT---VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG---VAQ 390
Cdd:PRK15079 9 LEVADLKVHFdiKDGKQwfwQPPKTlkaVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKATDGEVAWLGkdlLGM 88
|
90
....*....|....*...
gi 612265813 391 TAADMPDYRRLFSAIFTD 408
Cdd:PRK15079 89 KDDEWRAVRSDIQMIFQD 106
|
|
| ugpC |
PRK11650 |
sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC; |
321-387 |
2.92e-04 |
|
sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;
Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 43.29 E-value: 2.92e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 321 TLELRDVVFHYaDAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG 387
Cdd:PRK11650 3 GLKLQAVRKSY-DGKTQ---VIKGIDLDVADGEFIVLVGPSGCGKSTLLRMVAGLERITSGEIWIGG 65
|
|
| ycf16 |
CHL00131 |
sulfate ABC transporter protein; Validated |
345-399 |
3.51e-04 |
|
sulfate ABC transporter protein; Validated
Pssm-ID: 214372 [Multi-domain] Cd Length: 252 Bit Score: 42.32 E-value: 3.51e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTG--LYRPVSGHIVLDGVAQTAADmPDYR 399
Cdd:CHL00131 26 LNLSINKGEIHAIMGPNGSGKSTLSKVIAGhpAYKILEGDILFKGESILDLE-PEER 81
|
|
| ABC_Class2 |
cd03227 |
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
343-526 |
3.77e-04 |
|
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 41.19 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 343 GPLNLTLRRGELVFLIGGNGSGKSTL--AMLLTGLYRPVSGHIVLDGVAQtaadmpDYRRLFSAIFTdfhqfdrlqgpeg 420
Cdd:cd03227 12 VPNDVTFGEGSLTIITGPNGSGKSTIldAIGLALGGAQSATRRRSGVKAG------CIVAAVSAELI------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 421 gepdtalvahwlerlnmksklqfdgarVTNPQLSQGQ--RKRLALLLAVAE--QRDILLLDEWAADQDPQFRRIFYrELL 496
Cdd:cd03227 73 ---------------------------FTRLQLSGGEkeLSALALILALASlkPRPLYILDEIDRGLDPRDGQALA-EAI 124
|
170 180 190
....*....|....*....|....*....|
gi 612265813 497 PALRALGKTVFAISHDDHYFEHADRLLEMR 526
Cdd:cd03227 125 LEHLVKGAQVIVITHLPELAELADKLIHIK 154
|
|
| PRK15439 |
PRK15439 |
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional |
345-537 |
4.57e-04 |
|
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional
Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 42.73 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAQTAAD-----------MPDYRRLfSAIFTD----F 409
Cdd:PRK15439 282 ISLEVRAGEILGLAGVVGAGRTELAETLYGLRPARGGRIMLNGKEINALStaqrlarglvyLPEDRQS-SGLYLDaplaW 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 410 HQFDRLQGPEGGEPDTALVAHWLERLNMKSKLQFDGARVTNPQLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRR 489
Cdd:PRK15439 361 NVCALTHNRRGFWIKPARENAVLERYRRALNIKFNHAEQAARTLSGGNQQKVLIAKCLEASPQLLIVDEPTRGVDVSARN 440
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 612265813 490 IFYReLLPALRALGKTVFAISHDDHYFEH-ADRLLEMRSGHLR-ELTGSE 537
Cdd:PRK15439 441 DIYQ-LIRSIAAQNVAVLFISSDLEEIEQmADRVLVMHQGEISgALTGAA 489
|
|
| PRK13546 |
PRK13546 |
teichoic acids export ABC transporter ATP-binding subunit TagH; |
340-512 |
4.93e-04 |
|
teichoic acids export ABC transporter ATP-binding subunit TagH;
Pssm-ID: 184131 [Multi-domain] Cd Length: 264 Bit Score: 42.11 E-value: 4.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 340 FTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDGVAqtaadmpdyrrlfSAIFTDFHQFDRLQGPE 419
Cdd:PRK13546 38 FALDDISLKAYEGDVIGLVGINGSGKSTLSNIIGGSLSPTVGKVDRNGEV-------------SVIAISAGLSGQLTGIE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 420 GGEPDTALVAHWLERLN--MKSKLQFD--GARVTNP--QLSQGQRKRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYR 493
Cdd:PRK13546 105 NIEFKMLCMGFKRKEIKamTPKIIEFSelGEFIYQPvkKYSSGMRAKLGFSINITVNPDILVIDEALSVGDQTFAQKCLD 184
|
170
....*....|....*....
gi 612265813 494 ELLpALRALGKTVFAISHD 512
Cdd:PRK13546 185 KIY-EFKEQNKTIFFVSHN 202
|
|
| PTZ00265 |
PTZ00265 |
multidrug resistance protein (mdr1); Provisional |
320-386 |
7.39e-04 |
|
multidrug resistance protein (mdr1); Provisional
Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 42.71 E-value: 7.39e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 320 QTLELRDVVFHY---ADAEqqpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLD 386
Cdd:PTZ00265 381 KKIQFKNVRFHYdtrKDVE-----IYKDLNFTLTEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIIN 445
|
|
| PRK10982 |
PRK10982 |
galactose/methyl galaxtoside transporter ATP-binding protein; Provisional |
346-387 |
8.15e-04 |
|
galactose/methyl galaxtoside transporter ATP-binding protein; Provisional
Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 42.02 E-value: 8.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 612265813 346 NLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVLDG 387
Cdd:PRK10982 18 NLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGSILFQG 59
|
|
| PRK11147 |
PRK11147 |
ABC transporter ATPase component; Reviewed |
323-383 |
3.89e-03 |
|
ABC transporter ATPase component; Reviewed
Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 39.93 E-value: 3.89e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612265813 323 ELRDVVFHYADAEQQPGFTVgplnlTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHI 383
Cdd:PRK11147 321 EMENVNYQIDGKQLVKDFSA-----QVQRGDKIALIGPNGCGKTTLLKLMLGQLQADSGRI 376
|
|
| sufC |
PRK09580 |
cysteine desulfurase ATPase component; Reviewed |
345-478 |
4.10e-03 |
|
cysteine desulfurase ATPase component; Reviewed
Pssm-ID: 181965 [Multi-domain] Cd Length: 248 Bit Score: 39.00 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGL--YRPVSGHIVLDGVAQTAADMPDyrRLFSAIFTDF----------HQF 412
Cdd:PRK09580 20 LNLEVRPGEVHAIMGPNGSGKSTLSATLAGRedYEVTGGTVEFKGKDLLELSPED--RAGEGIFMAFqypveipgvsNQF 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612265813 413 ------DRLQGPEGGEP----DTA-LVAHWLERLNMKSKLQfdgARVTNPQLSQGQRKRLALLLAVAEQRDILLLDE 478
Cdd:PRK09580 98 flqtalNAVRSYRGQEPldrfDFQdLMEEKIALLKMPEDLL---TRSVNVGFSGGEKKRNDILQMAVLEPELCILDE 171
|
|
| met_CoM_red_A2 |
TIGR03269 |
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
345-511 |
4.44e-03 |
|
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]
Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 39.79 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 345 LNLTLRRGELVFLIGGNGSGKSTLAMLLTGL--YRPVSGHIV----------------LDG---------VAQTAADM-- 395
Cdd:TIGR03269 19 ISFTIEEGEVLGILGRSGAGKSVLMHVLRGMdqYEPTSGRIIyhvalcekcgyverpsKVGepcpvcggtLEPEEVDFwn 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612265813 396 ---PDYRRLFSAIFTDFHQFDRLQG------------PEGGEPDTALVAHWLERLNMkSKLqfdGARVTN--PQLSQGQR 458
Cdd:TIGR03269 99 lsdKLRRRIRKRIAIMLQRTFALYGddtvldnvlealEEIGYEGKEAVGRAVDLIEM-VQL---SHRITHiaRDLSGGEK 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 612265813 459 KRLALLLAVAEQRDILLLDEWAADQDPQFRRIFYRELLPALRALGKTVFAISH 511
Cdd:TIGR03269 175 QRVVLARQLAKEPFLFLADEPTGTLDPQTAKLVHNALEEAVKASGISMVLTSH 227
|
|
| GguA |
NF040905 |
sugar ABC transporter ATP-binding protein; |
322-387 |
6.67e-03 |
|
sugar ABC transporter ATP-binding protein;
Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 39.00 E-value: 6.67e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612265813 322 LELRD-VVFHYADAEQQpgfTVGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTG-LY-RPVSGHIVLDG 387
Cdd:NF040905 258 FEVKNwTVYHPLHPERK---VVDDVSLNVRRGEIVGIAGLMGAGRTELAMSVFGrSYgRNISGTVFKDG 323
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| ABCD_peroxisomal_ALDP |
cd03223 |
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
342-385 |
7.56e-03 |
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ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).
Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 37.52 E-value: 7.56e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 612265813 342 VGPLNLTLRRGELVFLIGGNGSGKSTLAMLLTGLYRPVSGHIVL 385
Cdd:cd03223 17 LKDLSFEIKPGDRLLITGPSGTGKSSLFRALAGLWPWGSGRIGM 60
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