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Conserved domains on  [gi|600146263|gb|EYK49548|]
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thiW protein [Staphylococcus aureus T45836]

Protein Classification

energy coupling factor transporter S component ThiW( domain architecture ID 10008775)

energy coupling factor transporter S component ThiW acts in the transport of a thiazole precursor of thiamine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThiW COG4732
ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism]; ...
 1-163 1.68e-60

ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism];


:

Pssm-ID: 443766  Cd Length: 165  Bit Score: 184.68  E-value: 1.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   1 MKSRKLAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIG 80
Cdd:COG4732    2 MKTRKLTLAALLVALGVVLSPLISIPVGPAKAFPVQHAINVLAAVLLGPWYAVGVAFIISLLRNLLGTGSLLAFPGSMIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263  81 VLLASMFYIYRKHIFMAAVGEVLGTGVIGSLICIPLAYFLGLQDFFIKPLMITFIVSSAIGSIISYFLLITLKKRGILQR 160
Cdd:COG4732   82 ALLAGLLYRKTKKIWLAALGEVIGTGIIGGLLAYPIAAPLMGKEVALFFFVPPFLISSIGGAIIGYLLLKALRRTGLLKR 161


                 ...
gi 600146263 161 FIK 163
Cdd:COG4732  162 LKK 164
 
Name Accession Description Interval E-value
ThiW COG4732
ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism]; ...
 1-163 1.68e-60

ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism];


Pssm-ID: 443766  Cd Length: 165  Bit Score: 184.68  E-value: 1.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   1 MKSRKLAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIG 80
Cdd:COG4732    2 MKTRKLTLAALLVALGVVLSPLISIPVGPAKAFPVQHAINVLAAVLLGPWYAVGVAFIISLLRNLLGTGSLLAFPGSMIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263  81 VLLASMFYIYRKHIFMAAVGEVLGTGVIGSLICIPLAYFLGLQDFFIKPLMITFIVSSAIGSIISYFLLITLKKRGILQR 160
Cdd:COG4732   82 ALLAGLLYRKTKKIWLAALGEVIGTGIIGGLLAYPIAAPLMGKEVALFFFVPPFLISSIGGAIIGYLLLKALRRTGLLKR 161


                 ...
gi 600146263 161 FIK 163
Cdd:COG4732  162 LKK 164
ThiW pfam09512
Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or ...
 6-155 1.11e-50

Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.


Pssm-ID: 430656  Cd Length: 150  Bit Score: 159.32  E-value: 1.11e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263    6 LAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIGVLLAS 85
Cdd:pfam09512   1 LTLAAVLIALGVALSPIFSIPVGVAKVFPVQHAINVLAGVLLGPWYALAVALVISLLRNLLGTGTLLAFPGSMFGALLAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   86 MFYIYRKHIFMAAVGEVLGTGVIGSLICIPLAYFLGLQDFFIKPLMITFIVSSAIGSIISYFLLITLKKR 155
Cdd:pfam09512  81 LLYRYTRKLYLAALGEVLGTGIIGALLAYPVAPLLMGSEAALFFFIPPFILSTLIGSVIGYIVLKALKKA 150
thiW TIGR02359
energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or ...
 4-160 1.25e-50

energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 131412  Cd Length: 160  Bit Score: 159.49  E-value: 1.25e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263    4 RKLAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIGVLL 83
Cdd:TIGR02359   2 RRLTLLALLIAIGVVLSQLIRIPVGPTKAAPVQHFVNVIAGVLLGPWYALAVAFIIGLLRNTLGLGTVLAFPGGMPGALL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 600146263   84 ASMFYIYRKHIFMAAVGEVLGTGVIGSLICIPLA-YFLGLQD-FFIKPLMITFIVSSAIGSIISYFLLITLKKRGILQR 160
Cdd:TIGR02359  82 AGLLYRFGRKHYWASLGEILGTGIIGSLLAYPVAaWLLGSSEnFALFPITLGFIVSTLIGSVIGWFVLVALKRTGVFRL 160
 
Name Accession Description Interval E-value
ThiW COG4732
ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism]; ...
 1-163 1.68e-60

ECF-type thiazole transporter, membrane (S) component ThiW [Coenzyme transport and metabolism];


Pssm-ID: 443766  Cd Length: 165  Bit Score: 184.68  E-value: 1.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   1 MKSRKLAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIG 80
Cdd:COG4732    2 MKTRKLTLAALLVALGVVLSPLISIPVGPAKAFPVQHAINVLAAVLLGPWYAVGVAFIISLLRNLLGTGSLLAFPGSMIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263  81 VLLASMFYIYRKHIFMAAVGEVLGTGVIGSLICIPLAYFLGLQDFFIKPLMITFIVSSAIGSIISYFLLITLKKRGILQR 160
Cdd:COG4732   82 ALLAGLLYRKTKKIWLAALGEVIGTGIIGGLLAYPIAAPLMGKEVALFFFVPPFLISSIGGAIIGYLLLKALRRTGLLKR 161


                 ...
gi 600146263 161 FIK 163
Cdd:COG4732  162 LKK 164
ThiW pfam09512
Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or ...
 6-155 1.11e-50

Thiamine-precursor transporter protein (ThiW); Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.


Pssm-ID: 430656  Cd Length: 150  Bit Score: 159.32  E-value: 1.11e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263    6 LAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIGVLLAS 85
Cdd:pfam09512   1 LTLAAVLIALGVALSPIFSIPVGVAKVFPVQHAINVLAGVLLGPWYALAVALVISLLRNLLGTGTLLAFPGSMFGALLAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   86 MFYIYRKHIFMAAVGEVLGTGVIGSLICIPLAYFLGLQDFFIKPLMITFIVSSAIGSIISYFLLITLKKR 155
Cdd:pfam09512  81 LLYRYTRKLYLAALGEVLGTGIIGALLAYPVAPLLMGSEAALFFFIPPFILSTLIGSVIGYIVLKALKKA 150
thiW TIGR02359
energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or ...
 4-160 1.25e-50

energy coupling factor transporter S component ThiW; Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 131412  Cd Length: 160  Bit Score: 159.49  E-value: 1.25e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263    4 RKLAITALLIAINVVLSSIIIIPLGPVKAAPVQHFVNVLSAVIVGPWYGLAQALISSILRVLFGTGTAFAFPGSMIGVLL 83
Cdd:TIGR02359   2 RRLTLLALLIAIGVVLSQLIRIPVGPTKAAPVQHFVNVIAGVLLGPWYALAVAFIIGLLRNTLGLGTVLAFPGGMPGALL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 600146263   84 ASMFYIYRKHIFMAAVGEVLGTGVIGSLICIPLA-YFLGLQD-FFIKPLMITFIVSSAIGSIISYFLLITLKKRGILQR 160
Cdd:TIGR02359  82 AGLLYRFGRKHYWASLGEILGTGIIGSLLAYPVAaWLLGSSEnFALFPITLGFIVSTLIGSVIGWFVLVALKRTGVFRL 160
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 4-154 4.18e-03

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 36.01  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263    4 RKLAITALLIAINVVLSSIIIIPLGPVKAAPVqHFVNVLSAVIVGPWYGLAQALISSILRVLFgTGTAFAFPGSMIGVLL 83
Cdd:TIGR04518   5 KNLTILALLVALSIILSRFLSIQTGNLRISFG-FLPVILAGMLFGPVAGAIVGAVADLLGCML-FGYGTFFPGFTLSAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 600146263   84 ASMFYIY------RKHIFMAAVGEVLGTGVIGSLICIPLAyflgLQDFFIKPLMITF---IVSSAIGSIISYFLLITLKK 154
Cdd:TIGR04518  83 TGLIYGLffykkkNKKLFLRLAAAVVIVQIIISLVLTSIW----LSILYGSPLTALLpirLIKAIIMIPVEIVVIYLLLK 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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