NCBI Conserved Domain Search

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

252-522

1.52e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 94.23 E-value: 1.52e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqRE 331
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE--EA 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 IARQKAEMDEKEKQRQvEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKS 411
Cdd:COG1196  367 LLEAEAELAEAEEELE-ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 412 EMEKKERERQQEIARQHAERQRKEEEARRQEearlfAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERL 491
Cdd:COG1196  446 EAAEEEAELEEEEEALLELLAELLEEAALLE-----AALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520

                        250       260       270
                 ....*....|....*....|....*....|.
gi 597837628 492 RKEEEQRIEAQRKAEEERRIEEQLAAREVEN 522
Cdd:COG1196  521 GLAGAVAVLIGVEAAYEAALEAALAAALQNI 551

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

202-464

8.20e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 69.32 E-value: 8.20e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   202 LKQLVRIVEAHQVAINKIEEQVgEERRRGGVEDHEhpagsfRKQGPSGNFEEgsSNAEMEQLErqrqQEIARQVAERQQK 281
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKL-EELRLEVSELEE------EIEELQKELYA--LANEISRLE----QQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   282 EREELEWQQEIARQEAERQRKEEEM-RRQQEYAQQMAEMQRAQKEMEwqrEIARQKAEMDEKEKQRQVEI---ARQMAER 357
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELaELEEKLEELKEELESLEAELE---ELEAELEELESRLEELEEQLetlRSKVAQL 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   358 QRQEEELLRQQEVALQEAERQKKERERQKeiarqvvERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEE 437
Cdd:TIGR02168  392 ELQIASLNNEIERLEARLERLEDRRERLQ-------QEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALE 464

                          250       260
                   ....*....|....*....|....*..
gi 597837628   438 ARRQEEARLFAERQKKERERQEEIARQ 464
Cdd:TIGR02168  465 ELREELEEAEQALDAAERELAQLQARL 491

GBP_C

cd16269

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...

280-424

3.45e-07

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.

Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 52.96 E-value: 3.45e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 280 QKEREELEwqqEIARQEAERQRKEEE-----MRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRqveiarqM 354
Cdd:cd16269  148 LEDREKLV---EKYRQVPRKGVKAEEvlqefLQSKEAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKL-------L 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628 355 AERQRQEEELLRQQEVALQEAERQ---KKERERQKEIARQvveRKKQEEVRRIEKARKKSEMEKKERERQQEI 424
Cdd:cd16269  218 EEQQRELEQKLEDQERSYEEHLRQlkeKMEEERENLLKEQ---ERALESKLKEQEALLEEGFKEQAELLQEEI 287

growth_prot_Scy

NF041483

polarized growth protein Scy;

264-547

4.06e-05

polarized growth protein Scy;

Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 47.51 E-value: 4.06e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKErEELEWqqeiARQEAERQRKE-----EEMRRQQEYA----QQMAEMQRAQKEMEWQREIAR 334
Cdd:NF041483  505 ERVRTEAIERATTLRRQAE-ETLER----TRAEAERLRAEaeeqaEEVRAAAERAarelREETERAIAARQAEAAEELTR 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  335 QKAEMDEK--EKQRQVEIARQMAERQRQE--EELLRQQEVA------LQEAERQKKERERQKEIARQVVERKKQEEVRRI 404
Cdd:NF041483  580 LHTEAEERltAAEEALADARAEAERIRREaaEETERLRTEAaerirtLQAQAEQEAERLRTEAAADASAARAEGENVAVR 659

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  405 EKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERqeeiaRQMEEEEKRQREEAEKEEMRKR 484
Cdd:NF041483  660 LRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQEEAARRR-----REAEETLGSARAEADQERERAR 734

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628  485 KIEEERLRKEEEQRIEAQRKA-----EEERRIEEQLAAREVENQStVVNPAFGMH------IPGETQAGEHSTD 547
Cdd:NF041483  735 EQSEELLASARKRVEEAQAEAqrlveEADRRATELVSAAEQTAQQ-VRDSVAGLQeqaeeeIAGLRSAAEHAAE 807

OmpH

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

314-407

5.50e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.

Pssm-ID: 214922 [Multi-domain] Cd Length: 140 Bit Score: 43.73 E-value: 5.50e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   314 QQMAEMQRAQKEMEwqREIARQKAEMDEKEKQrqveiARQMAERQRQEEELLRQQEVALQEAERQKKERE--RQKEIARQ 391
Cdd:smart00935  11 QESPAGKAAQKQLE--KEFKKRQAELEKLEKE-----LQKLKEKLQKDAATLSEAAREKKEKELQKKVQEfqRKQQKLQQ 83

                           90
                   ....*....|....*.
gi 597837628   392 VVERKKQEEVRRIEKA 407
Cdd:smart00935  84 DLQKRQQEELQKILDK 99

Agg_substance

NF033875

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...

96-341

2.29e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.

Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 45.09 E-value: 2.29e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   96 PEPTTVRPYRPVFTTPNrKIVSSAATKSPKPPPTRTTATTLTTPPLKNRKVTEPIPVSEAQMTGMQPSTRGYTRGPQMHT 175
Cdd:NF033875   50 PGTTTVQPDNPDPQSGS-ETPKTAVSEEATVQKDTTSQPTKVEEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  176 tgVTAGTTSGEHMVNYKGITMSEDEFLKQLVRIVEAHQVAINKieeQVGEERRRGGVEDHEHPAGSFrkqGPSGNFEEGS 255
Cdd:NF033875  129 --VVSPETTNEPLGQPTEVAPAENEANKSTSIPKEFETPDVDK---AVDEAKKDPNITVVEKPAEDL---GNVSSKDLAA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  256 SNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEI-ARQEAERQRKEEEMRRQQEYAQQMAEMQRA-QKEMEWQREIA 333
Cdd:NF033875  201 KEKEVDQLQKEQAKKIAQQAAELKAKNEKIAKENAEIaAKNKAEKERYEKEVAEYNKHKNENGYVNEAiSKNLVFDQSVV 280


                  ....*...
gi 597837628  334 RQKAEMDE 341
Cdd:NF033875  281 TKDTKISS 288

PspC_subgroup_1

NF033838

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...

251-581

9.92e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.

Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 39.61 E-value: 9.92e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 251 FEEGSSNAEMEQLERQRQQEIARQVAERQQKER--------------EELEWQQEIARQEAER-QRKEEEMRRQQEYAQQ 315
Cdd:NF033838 130 FKKDTLEPGKKVAEATKKVEEAEKKAKDQKEEDrrnyptntyktlelEIAESDVEVKKAELELvKEEAKEPRDEEKIKQA 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 316 MAEMQRAQKEMEWQREIA--RQKAEMDEKEKQ--RQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQ 391
Cdd:NF033838 210 KAKVESKKAEATRLEKIKtdREKAEEEAKRRAdaKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSS 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 392 V-----------VERKKQEEVRRIEKARKKSEMEKKERERQ-QEIARQHAERQRKEEEARRQEEARLFAERQKKERERQE 459
Cdd:NF033838 290 VgeetlpspslkPEKKVAEAEKKVEEAKKKAKDQKEEDRRNyPTNTYKTLELEIAESDVKVKEAELELVKEEAKEPRNEE 369

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 460 EIarqmeEEEKRQREEAEKEEMRKRKIEEERLRKEEeqriEAQRK-AEEERRIEEQLAAREVENQSTVVNPAFGMHIPGE 538
Cdd:NF033838 370 KI-----KQAKAKVESKKAEATRLEKIKTDRKKAEE----EAKRKaAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAE 440

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 597837628 539 TQAGEHSTDYYG---YSTNSDATktvlaglmsmSSRLTSTEPPQLE 581
Cdd:NF033838 441 QPKAEKPADQQAeedYARRSEEE----------YNRLTQQQPPKTE 476

Name

Accession

Description

Interval

E-value

DUF5401

pfam17380

Family of unknown function (DUF5401); This is a family of unknown function found in ...

39-696

1.06e-43

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.

Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 169.92 E-value: 1.06e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   39 EEFIFSTKRPKRPRPKTKAASStltaaptsaasssthpstttptpTVAFPTPALLPTPEPTTVRPYRPVFTTPNRKIVSS 118
Cdd:pfam17380 101 EEFVFSTIRPKSRKPKARTRGK-----------------------KRKTTTTMIQTTTPMMVTTSSSALEMTTTPKIVIF 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  119 AATKSPKPPPTRTTATTLTTPPLKNRKV------------TEPIPVSEA---------------QMTGMQPSTRGYT--- 168
Cdd:pfam17380 158 ASKKNASGGNRSGEQRKQIQLIRRRRGNhsaftrpgrprtTTPMPVTHAtrfvpgiqmstvapkEVQGMPHTLAPYEkme 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  169 RGPQMHTTGVTAGTTSGEHMVNYKGITMSEDEFLKQLVRIVEaHQVAINKIEEQvgeerrrggvEDHEHPAGSFRKQGPS 248
Cdd:pfam17380 238 RRKESFNLAEDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQ-HQKAVSERQQQ----------EKFEKMEQERLRQEKE 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  249 GNFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMqraqkemew 328
Cdd:pfam17380 307 EKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRM--------- 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  329 qREIARQKAEMDEKEkqrqveiarqmaERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKAR 408
Cdd:pfam17380 378 -RELERLQMERQQKN------------ERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEER 444

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  409 KKsemeKKERERQQEIARQHaERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEE 488
Cdd:pfam17380 445 AR----EMERVRLEEQERQQ-QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  489 ERLRKEEEQRIEAQ--RKAEEERRIEEQLAARE---------VENQSTVVNPAFGMHIPGETQAGEHSTDYYGYSTNSDA 557
Cdd:pfam17380 520 KEMEERQKAIYEEErrREAEEERRKQQEMEERRriqeqmrkaTEERSRLEAMEREREMMRQIVESEKARAEYEATTPITT 599

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  558 TKTVlaglmsMSSRLTSTEPPQLE--IIHFTAPPPtpsspanEWVT-SPHSWRPPPDMQTNVLEWSRTPIpstgtselps 634
Cdd:pfam17380 600 IKPI------YRPRISEYQPPDVEshMIRFTTQSP-------EWATpSPATWNPEWNTVTAEEETPGIPI---------- 656

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597837628  635 tVTSECDSNVECAFSYEDDLLCPHPNDATRYLQCTPMIGRRGRWTERMCPPNLVFIPSYGRC 696
Cdd:pfam17380 657 -IHSQCQVNGECELKYDSDSFCAHPSNPSMYLQCAPLYGRLGRWTERHCPDTLIFIVSIGRC 717

PTZ00121

MAEBL; Provisional

252-521

4.45e-23

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 106.38 E-value: 4.45e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  252 EEGSSNAEMEQLERQRQQEIARQVAERQQKErEELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQRE 331
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAKKKAEEKKKA-DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  332 IARQKAEMDEK-EKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQK---EIARQVVERKKQEEVRRIEKA 407
Cdd:PTZ00121 1442 EAKKADEAKKKaEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKkadEAKKAAEAKKKADEAKKAEEA 1521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  408 RKKSEMEKKERERQQEIARQHAERQR----KEEEARRQEEARLFAERQKKERE------RQEEIARQMEEEEKRQREEAE 477
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAKKAEEKKKadelKKAEELKKAEEKKKAEEAKKAEEdknmalRKAEEAKKAEEARIEEVMKLY 1601

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 597837628  478 KEEmRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVE 521
Cdd:PTZ00121 1602 EEE-KKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE 1644

PTZ00121

MAEBL; Provisional

252-523

5.68e-22

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 102.91 E-value: 5.68e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  252 EEGSSNAE--MEQLERQRQQEIARQVAERQQKEREELEWQQEiARQEAERQRKEEEMR------RQQEYAQQMAEMQRAQ 323
Cdd:PTZ00121 1394 DEAKKKAEedKKKADELKKAAAAKKKADEAKKKAEEKKKADE-AKKKAEEAKKADEAKkkaeeaKKAEEAKKKAEEAKKA 1472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  324 KEMEWQREIARQKAEMDEK--EKQRQVEIARQMAERQRQEEELlRQQEVALQEAERQKKERERQKEIARQVVERKKQEEV 401
Cdd:PTZ00121 1473 DEAKKKAEEAKKADEAKKKaeEAKKKADEAKKAAEAKKKADEA-KKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL 1551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  402 RRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEM 481
Cdd:PTZ00121 1552 KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE 1631

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 597837628  482 RKRKIEEERLRKEEEQRIEAQRKAEEERRIE-EQLAAREVENQ 523
Cdd:PTZ00121 1632 KKKVEQLKKKEAEEKKKAEELKKAEEENKIKaAEEAKKAEEDK 1674

PTZ00121

MAEBL; Provisional

198-526

9.84e-21

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 98.67 E-value: 9.84e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  198 EDEFLKQLVRIVEAhqvAINKIEEQVGEERRRGGVED---HEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQ 274
Cdd:PTZ00121 1221 EDAKKAEAVKKAEE---AKKDAEEAKKAEEERNNEEIrkfEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKK 1297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  275 VAERQQ-----KEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQR-EIARQKAEMDEK---EKQ 345
Cdd:PTZ00121 1298 AEEKKKadeakKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEaEAAEEKAEAAEKkkeEAK 1377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  346 RQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQvveRKKQEEVRRIEKARKKSEMEKKERErqqeiA 425
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEA---KKKAEEKKKADEAKKKAEEAKKADE-----A 1449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  426 RQHAERQRKEEEARRQEEARLFAERQKK---ERERQEEIARQMEEEEKRQREEAEKEEMRKR----KIEEERLRKEEEQR 498
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKKKAEEAKKADEAKKkaeEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeaKKAEEAKKADEAKK 1529

                         330       340
                  ....*....|....*....|....*...
gi 597837628  499 IEAQRKAEEERRIEEQLAAREVENQSTV 526
Cdd:PTZ00121 1530 AEEAKKADEAKKAEEKKKADELKKAEEL 1557

PTZ00121

MAEBL; Provisional

220-523

1.23e-20

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 98.29 E-value: 1.23e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  220 EEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEmeqlERQRQQEIARQVAERQQ----KEREELEWQQEIARQ 295
Cdd:PTZ00121 1389 EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAE----EKKKADEAKKKAEEAKKadeaKKKAEEAKKAEEAKK 1464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  296 EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAemdekEKQRQVEIARQMAERQRQEEelLRQQEVALQEA 375
Cdd:PTZ00121 1465 KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA-----EAKKKADEAKKAEEAKKADE--AKKAEEAKKAD 1537

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  376 ERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEmEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKER 455
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE-DKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAE 1616

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597837628  456 E---RQEEIAR-QMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:PTZ00121 1617 EakiKAEELKKaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEK 1688

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

252-522

1.52e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 94.23 E-value: 1.52e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqRE 331
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE--EA 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 IARQKAEMDEKEKQRQvEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKS 411
Cdd:COG1196  367 LLEAEAELAEAEEELE-ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 412 EMEKKERERQQEIARQHAERQRKEEEARRQEearlfAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERL 491
Cdd:COG1196  446 EAAEEEAELEEEEEALLELLAELLEEAALLE-----AALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520

                        250       260       270
                 ....*....|....*....|....*....|.
gi 597837628 492 RKEEEQRIEAQRKAEEERRIEEQLAAREVEN 522
Cdd:COG1196  521 GLAGAVAVLIGVEAAYEAALEAALAAALQNI 551

PTZ00121

MAEBL; Provisional

264-521

3.98e-19

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 93.28 E-value: 3.98e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKErEELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwQREIARQKAEMDEKE 343
Cdd:PTZ00121 1454 EEAKKAEEAKKKAEEAKKA-DEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK-KAEEAKKADEAKKAE 1531

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  344 KQRQVEIARQmAERQRQEEELLRQQEValQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQ- 422
Cdd:PTZ00121 1532 EAKKADEAKK-AEEKKKADELKKAEEL--KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMk 1608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  423 -EIARQHAERQRKEEEARRQEEARLFAERQKK----ERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEE-ERLRKEEE 496
Cdd:PTZ00121 1609 aEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKkeaeEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEaKKAEEDEK 1688

                         250       260
                  ....*....|....*....|....*
gi 597837628  497 QRIEAQRKAEEERRIEEQLAAREVE 521
Cdd:PTZ00121 1689 KAAEALKKEAEEAKKAEELKKKEAE 1713

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

265-521

6.23e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 92.31 E-value: 6.23e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRR-QQEYAQQMAEMQRAQKEMEwqrEIARQKAEMDEKE 343
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEElELELEEAQAEEYELLAELA---RLEQDIARLEERR 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 344 KQRQVEIARQMAERQRQEEELLRQQEvALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQE 423
Cdd:COG1196  312 RELEERLEELEEELAELEEELEELEE-ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 424 IARQHAERQRKEEEARRQEEARLfAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQR 503
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALL-ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                        250
                 ....*....|....*...
gi 597837628 504 KAEEERRIEEQLAAREVE 521
Cdd:COG1196  470 EEAALLEAALAELLEELA 487

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

257-524

3.20e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 90.00 E-value: 3.20e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 257 NAEMEQLERQRQQEIARQvaERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQK 336
Cdd:COG1196  245 EAELEELEAELEELEAEL--AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELE 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 337 AEMDEKEKQRQvEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKK 416
Cdd:COG1196  323 EELAELEEELE-ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 417 ERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEE 496
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                        250       260
                 ....*....|....*....|....*...
gi 597837628 497 QRIEAQRKAEEERRIEEQLAAREVENQS 524
Cdd:COG1196  482 LLEELAEAAARLLLLLEAEADYEGFLEG 509

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

260-523

5.77e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 89.23 E-value: 5.77e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 260 MEQLERQRQQ--------------EIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMR-RQQEYAQQMAEMQRAQK 324
Cdd:COG1196  202 LEPLERQAEKaeryrelkeelkelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAeLEAELEELRLELEELEL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 325 EMEW-QREIARQKAEMDEKEKQRQVEIARQmAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRR 403
Cdd:COG1196  282 ELEEaQAEEYELLAELARLEQDIARLEERR-RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 404 IEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQkkERERQEEIARQMEEEEKRQREEAEKEEMRK 483
Cdd:COG1196  361 AEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA--EEALLERLERLEEELEELEEALAELEEEEE 438

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 597837628 484 RKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:COG1196  439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

258-521

7.78e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 88.84 E-value: 7.78e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQR---QQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEM-RRQQEYAQQMAEMQRAQKEMEWQREIA 333
Cdd:COG1196  232 LKLRELEAELeelEAELEELEAELEELEAELAELEAELEELRLELEELELELeEAQAEEYELLAELARLEQDIARLEERR 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 334 RQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEvALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKksem 413
Cdd:COG1196  312 RELEERLEELEEELAELEEELEELEEELEELEEELE-EAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE---- 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 414 EKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRK 493
Cdd:COG1196  387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                        250       260
                 ....*....|....*....|....*...
gi 597837628 494 EEEQRIEAQRKAEEERRIEEQLAAREVE 521
Cdd:COG1196  467 ELLEEAALLEAALAELLEELAEAAARLL 494

PTZ00121

MAEBL; Provisional

210-513

1.63e-17

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 88.27 E-value: 1.63e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  210 EAHQVAINKIEEQVGEERRRGGVEDhehpagsFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQV--AERQQKEREELE 287
Cdd:PTZ00121 1102 EAKKTETGKAEEARKAEEAKKKAED-------ARKAEEARKAEDARKAEEARKAEDAKRVEIARKAedARKAEEARKAED 1174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  288 WQQEIARQEAERQRKEEEMRRQQEyAQQMAEMQRAqkEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQ 367
Cdd:PTZ00121 1175 AKKAEAARKAEEVRKAEELRKAED-ARKAEAARKA--EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNN 1251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  368 QEVALQEAERQKKERERQKEIARQvvERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAE-RQRKEEEARRQEEARL 446
Cdd:PTZ00121 1252 EEIRKFEEARMAHFARRQAAIKAE--EARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEeAKKADEAKKKAEEAKK 1329

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628  447 FAERQKKERERQEEIARQMEEEEKRQREEAEKEEmRKRKIEEERLRKEEEQRIEAQRKAEEERRIEE 513
Cdd:PTZ00121 1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAE-EKAEAAEKKKEEAKKKADAAKKKAEEKKKADE 1395

PTZ00121

MAEBL; Provisional

206-514

1.98e-17

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 87.89 E-value: 1.98e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  206 VRIVEAHQVAIN--KIEE--QVGEERRRGGVEDHEHPAgsfRKQGPSGNFEEGSSNAEMEQLERQRQQEIAR-QVAERQQ 280
Cdd:PTZ00121 1199 ARKAEAARKAEEerKAEEarKAEDAKKAEAVKKAEEAK---KDAEEAKKAEEERNNEEIRKFEEARMAHFARrQAAIKAE 1275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  281 KEREELEWQQEIARQEAERQRKEEEMRRQQEyAQQMAEMQRAQKEMEWQREIARQKAEmdekEKQRQVEIARQMAERQRQ 360
Cdd:PTZ00121 1276 EARKADELKKAEEKKKADEAKKAEEKKKADE-AKKKAEEAKKADEAKKKAEEAKKKAD----AAKKKAEEAKKAAEAAKA 1350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  361 EEELLRQQevaLQEAERQKKERERQKEIARQVVE--RKKQEEVRRIEKARKKSEMEKKERE--RQQEIARQHAER-QRKE 435
Cdd:PTZ00121 1351 EAEAAADE---AEAAEEKAEAAEKKKEEAKKKADaaKKKAEEKKKADEAKKKAEEDKKKADelKKAAAAKKKADEaKKKA 1427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  436 EEARRQEEARLFAERQKK--ERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEE 513
Cdd:PTZ00121 1428 EEKKKADEAKKKAEEAKKadEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAE 1507


                  .
gi 597837628  514 Q 514
Cdd:PTZ00121 1508 A 1508

PTZ00121

MAEBL; Provisional

218-514

4.97e-17

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 86.73 E-value: 4.97e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  218 KIEEQVGEERRRGGVEDHEHPAGSFRKQGpsgnfEEGSSNAEMEQLERQRQQEIARQVAERqqKEREELEWQQEIarQEA 297
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKKKADEAKKAA-----EAKKKADEAKKAEEAKKADEAKKAEEA--KKADEAKKAEEK--KKA 1548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  298 ERQRKEEEMRRqqeyAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAER 377
Cdd:PTZ00121 1549 DELKKAEELKK----AEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  378 QKKERERQKEIARqvVERKKQEEVRRIEKARKKSE---MEKKERERQQEIARQHAERQRKEEEARRQEEARLfaERQKKE 454
Cdd:PTZ00121 1625 LKKAEEEKKKVEQ--LKKKEAEEKKKAEELKKAEEenkIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEAL--KKEAEE 1700

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  455 RERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEErlRKEEEqriEAQRKAEEERRIEEQ 514
Cdd:PTZ00121 1701 AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA--KKEAE---EDKKKAEEAKKDEEE 1755

PTZ00121

MAEBL; Provisional

218-521

6.92e-17

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 85.96 E-value: 6.92e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  218 KIEEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEmeqlERQRQQEIARQVAErQQKEREELEWQQEIARQE- 296
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAE----EAKKKADEAKKAAE-AKKKADEAKKAEEAKKADe 1526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  297 ---AERQRKEEEMRRQQEY--AQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQmAERQRQEEELLRQQEVA 371
Cdd:PTZ00121 1527 akkAEEAKKADEAKKAEEKkkADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKK-AEEARIEEVMKLYEEEK 1605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  372 LQEAERQKKERErqkeiarqvvERKKQEEVRRIEKARKKSEMEKKERERQQEIARQ-----HAERQRKEEEARRQEEARL 446
Cdd:PTZ00121 1606 KMKAEEAKKAEE----------AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkaeEENKIKAAEEAKKAEEDKK 1675

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  447 FAERQKKERERQEEIARQMEEEEKRQR-----EEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVE 521
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKkaeelKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE 1755

PTZ00121

MAEBL; Provisional

216-454

9.47e-17

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 85.58 E-value: 9.47e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  216 INKIEEQVGEERRRGGVEDHEHPAgsfrKQGPSGNFEEGSSNAEMEQL---ERQRQQEIARQVAERQQKEREELEWQQEI 292
Cdd:PTZ00121 1563 KKKAEEAKKAEEDKNMALRKAEEA----KKAEEARIEEVMKLYEEEKKmkaEEAKKAEEAKIKAEELKKAEEEKKKVEQL 1638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  293 ARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVeiaRQMAERQRQEEELLRQQEVAL 372
Cdd:PTZ00121 1639 KKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEAL---KKEAEEAKKAEELKKKEAEEK 1715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  373 QEAERQKKERERQKEIARQVV-----ERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLF 447
Cdd:PTZ00121 1716 KKAEELKKAEEENKIKAEEAKkeaeeDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRME 1795


                  ....*..
gi 597837628  448 AERQKKE 454
Cdd:PTZ00121 1796 VDKKIKD 1802

PTZ00121

MAEBL; Provisional

240-513

1.13e-16

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 85.58 E-value: 1.13e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  240 GSFRKQGPSgnfeegSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEyAQQMAEM 319
Cdd:PTZ00121 1067 GQDEGLKPS------YKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEE-ARKAEDA 1139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  320 QRAQKemewqreiARQKAEMDEKEKQRQVEIARQMAERQRQEEEllRQQEVALQEAERQKKERERQKEIARQVVERKKQE 399
Cdd:PTZ00121 1140 RKAEE--------ARKAEDAKRVEIARKAEDARKAEEARKAEDA--KKAEAARKAEEVRKAEELRKAEDARKAEAARKAE 1209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  400 EVRRIEKARKKSEMEKKERERQQEIARQHAErqrkeeEARRQEEARLFAERQKKERERQEEIARQmeEEEKRQREEAEKE 479
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAE------EAKKAEEERNNEEIRKFEEARMAHFARR--QAAIKAEEARKAD 1281

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 597837628  480 EMRK----RKIEEERLRKEEEQRIEAQRKAEEERRIEE 513
Cdd:PTZ00121 1282 ELKKaeekKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

YqiK

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

274-419

2.01e-16

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 82.61 E-value: 2.01e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 274 QVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAqqMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQ 353
Cdd:COG2268  196 EIIRDARIAEAEAERETEIAIAQANREAEEAELEQEREIE--TARIAEAEAELAKKKAEERREAETARAEAEAAYEIAEA 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628 354 MAER--QRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRriEKARKKSEMEKKERE 419
Cdd:COG2268  274 NAERevQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAE--AEAEAEAIRAKGLAE 339

PTZ00121

MAEBL; Provisional

252-523

2.62e-16

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 84.42 E-value: 2.62e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  252 EEGSSNAEMEQLERQRQQEIARQVAERqqKEREELEWQQEIARQE----AERQRKEEEMR----RQQEYAQQmAEMQRAQ 323
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEEK--KKADELKKAEELKKAEekkkAEEAKKAEEDKnmalRKAEEAKK-AEEARIE 1595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  324 KEMEWQREIARQKAEMDEKEKQRQV--EIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKeIARQVVERKKQEEV 401
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIkaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK-IKAAEEAKKAEEDK 1674

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  402 RRIEKARKKSEMEKKERE---RQQEIARQHAERQRKEEEARRQeearlfAERQKKERERQE---EIARQMEEEEKRQREE 475
Cdd:PTZ00121 1675 KKAEEAKKAEEDEKKAAEalkKEAEEAKKAEELKKKEAEEKKK------AEELKKAEEENKikaEEAKKEAEEDKKKAEE 1748

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 597837628  476 AEKEEMRKRKIEEERLrkeeeqriEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:PTZ00121 1749 AKKDEEEKKKIAHLKK--------EEEKKAEEIRKEKEAVIEEELDEE 1788

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

261-519

3.64e-14

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 74.57 E-value: 3.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEA-ERQRKEEEMRRQQEYAQQMAEMQRAQKEMewQREIARQKAEM 339
Cdd:pfam13868  26 AQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEkEEERKEERKRYRQELEEQIEEREQKRQEE--YEEKLQEREQM 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  340 DEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQK-KERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKER 418
Cdd:pfam13868 104 DEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKeLEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  419 ERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQR 498
Cdd:pfam13868 184 REIARLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEF 263

                         250       260
                  ....*....|....*....|.
gi 597837628  499 IEAQRKAEEERRIEEQLAARE 519
Cdd:pfam13868 264 ERMLRKQAEDEEIEQEEAEKR 284

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

261-523

7.81e-14

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 73.80 E-value: 7.81e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQ----EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQK 336
Cdd:pfam13868  47 EMMEEERERALEEEEEKEEERKEERKRYRQELEEQieerEQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQR 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  337 AEMDEKEKQRQVEIARQMAERQRQEEELLRqqevaLQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKK 416
Cdd:pfam13868 127 QLREEIDEFNEEQAEWKELEKEEEREEDER-----ILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKA 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  417 ERER------QQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKrqreeaEKEEMRKRKieeer 490
Cdd:pfam13868 202 ERDElraklyQEEQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEE------EFERMLRKQ----- 270

                         250       260       270
                  ....*....|....*....|....*....|...
gi 597837628  491 lrkeeEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:pfam13868 271 -----AEDEEIEQEEAEKRRMKRLEHRRELEKQ 298

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

258-513

2.05e-13

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 72.64 E-value: 2.05e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAE---MQRAQKEMEWQREIAR 334
Cdd:pfam13868  93 YEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEderILEYLKEKAEREEERE 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  335 QKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIArqvveRKKQEEVRRIEKARKKsEME 414
Cdd:pfam13868 173 AEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEA-----EKKARQRQELQQAREE-QIE 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  415 KKERERQQEIARQHAERQR--KEEEARRQEEARLFAERQKKERERQEEIARQMeeeekrqreeAEKEEMRKRKIEEERLR 492
Cdd:pfam13868 247 LKERRLAEEAEREEEEFERmlRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQI----------EEREEQRAAEREEELEE 316

                         250       260
                  ....*....|....*....|.
gi 597837628  493 KEEeqriEAQRKAEEERRIEE 513
Cdd:pfam13868 317 GER----LREEEAERRERIEE 333

tolA

cell envelope integrity inner membrane protein TolA; Provisional

256-430

1.23e-12

cell envelope integrity inner membrane protein TolA; Provisional

Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 70.61 E-value: 1.23e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 256 SNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQR-KEEEMRRQQEyaqqmaemQRAQKEMEWQREIAR 334
Cdd:PRK09510  57 PGAVVEQYNRQQQQQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERlKQLEKERLAA--------QEQKKQAEEAAKQAA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 335 QKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQevalQEAERQKKERERQKeiARQVVERKKQEEVRRIEK----ARKK 410
Cdd:PRK09510 129 LKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKK----AAAEAKKKAEAEAA--KKAAAEAKKKAEAEAAAKaaaeAKKK 202

                        170       180
                 ....*....|....*....|
gi 597837628 411 SEMEKKERERQQEIARQHAE 430
Cdd:PRK09510 203 AEAEAKKKAAAEAKKKAAAE 222

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

202-464

8.20e-12

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 69.32 E-value: 8.20e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   202 LKQLVRIVEAHQVAINKIEEQVgEERRRGGVEDHEhpagsfRKQGPSGNFEEgsSNAEMEQLErqrqQEIARQVAERQQK 281
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKL-EELRLEVSELEE------EIEELQKELYA--LANEISRLE----QQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   282 EREELEWQQEIARQEAERQRKEEEM-RRQQEYAQQMAEMQRAQKEMEwqrEIARQKAEMDEKEKQRQVEI---ARQMAER 357
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELaELEEKLEELKEELESLEAELE---ELEAELEELESRLEELEEQLetlRSKVAQL 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   358 QRQEEELLRQQEVALQEAERQKKERERQKeiarqvvERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEE 437
Cdd:TIGR02168  392 ELQIASLNNEIERLEARLERLEDRRERLQ-------QEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALE 464

                          250       260
                   ....*....|....*....|....*..
gi 597837628   438 ARRQEEARLFAERQKKERERQEEIARQ 464
Cdd:TIGR02168  465 ELREELEEAEQALDAAERELAQLQARL 491

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

258-465

1.34e-11

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 66.87 E-value: 1.34e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEIARQVAERQ-QKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMaemQRAQKEMEWQREIARQK 336
Cdd:pfam13868 140 AEWKELEKEEEREEDERILEYLkEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDE---KAERDELRAKLYQEEQE 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  337 AEMDEKEKQrqveiarQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKK 416
Cdd:pfam13868 217 RKERQKERE-------EAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRL 289

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 597837628  417 ERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQM 465
Cdd:pfam13868 290 EHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

250-464

2.70e-11

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 67.77 E-value: 2.70e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   250 NFEEGSSNAEMEQLERQ---RQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEyaqQMAEMQRAQKEM 326
Cdd:TIGR02168  245 QEELKEAEEELEELTAElqeLEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRE---RLANLERQLEEL 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   327 EWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQ-VVERKKQEEV--RR 403
Cdd:TIGR02168  322 EAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSkVAQLELQIASlnNE 401

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628   404 IEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQ 464
Cdd:TIGR02168  402 IERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEA 462

DUF4670

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

263-432

4.31e-11

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 66.51 E-value: 4.31e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  263 LERQRQQEIARQV--AERQQKEREELEW----QQEIARQEAERQRKEEEMRRQQEYAQQ-MAEMQRAQKEmewQREIARQ 335
Cdd:pfam15709 325 LEKREQEKASRDRlrAERAEMRRLEVERkrreQEEQRRLQQEQLERAEKMREELELEQQrRFEEIRLRKQ---RLEEERQ 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  336 KAEMDEKEKQRQVEIARQMAERQRQE---EELLRQQEVALQEAERQKKERERQKEIARQVVERKKQ----EEVRRIEKAR 408
Cdd:pfam15709 402 RQEEEERKQRLQLQAAQERARQQQEEfrrKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRlmemAEEERLEYQR 481

                         170       180
                  ....*....|....*....|....
gi 597837628  409 KKSEMEKKERERQQEiARQHAERQ 432
Cdd:pfam15709 482 QKQEAEEKARLEAEE-RRQKEEEA 504

tolA

cell envelope integrity inner membrane protein TolA; Provisional

304-432

8.79e-11

cell envelope integrity inner membrane protein TolA; Provisional

Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 64.83 E-value: 8.79e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 304 EEMRRQQeyaQQMAEMQRAQKEMEWQRE-IARQKAEMDEKEKQRQVEIARQMAERQRQEEellrQQEVALQEAERQKKER 382
Cdd:PRK09510  62 EQYNRQQ---QQQKSAKRAEEQRKKKEQqQAEELQQKQAAEQERLKQLEKERLAAQEQKK----QAEEAAKQAALKQKQA 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 597837628 383 ERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:PRK09510 135 EEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAK 184

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

258-523

8.79e-11

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 65.85 E-value: 8.79e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   258 AEME-QLER-QRQQEIARQVAErQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIAR- 334
Cdd:TIGR02168  196 NELErQLKSlERQAEKAERYKE-LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRl 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   335 QKAEMDEKEKQRQ-------VEIAR--QMAERQRQEEELLRQQEVALQEA-ERQKKERERQKEIARQVVERKK--QEEVR 402
Cdd:TIGR02168  275 EVSELEEEIEELQkelyalaNEISRleQQKQILRERLANLERQLEELEAQlEELESKLDELAEELAELEEKLEelKEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   403 RIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQ---------KKERERQEEIARQMEEEEKRQR 473
Cdd:TIGR02168  355 SLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIErlearlerlEDRRERLQQEIEELLKKLEEAE 434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 597837628   474 EEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQ--LAAREVENQ 523
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQalDAAERELAQ 486

YqiK

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

329-456

9.73e-11

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 64.89 E-value: 9.73e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 329 QREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQE-----EVRR 403
Cdd:COG2268  193 KIAEIIRDARIAEAEAERETEIAIAQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAETARAEaeaayEIAE 272

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 597837628 404 IEkARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERE 456
Cdd:COG2268  273 AN-AEREVQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAE 324

YqiK

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

307-432

1.10e-10

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 64.89 E-value: 1.10e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 307 RRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIA-RQMAERQRqeeELLRQQEVALQEAERQKKERERQ 385
Cdd:COG2268  191 RRKIAEIIRDARIAEAEAERETEIAIAQANREAEEAELEQEREIEtARIAEAEA---ELAKKKAEERREAETARAEAEAA 267

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 597837628 386 KEIARQVVER--KKQEEVRRIEKARKKSEMEKKERERQQE---IARQHAERQ 432
Cdd:COG2268  268 YEIAEANAERevQRQLEIAEREREIELQEKEAEREEAELEadvRKPAEAEKQ 319

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

251-516

1.30e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 65.38 E-value: 1.30e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   251 FEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQ---QEIARQEAERQRKEEEM---RRQQEYAQQMAEMQRAQK 324
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKlqeLKLKEQAKKALEYYQLKeklELEEEYLLYLDYLKLNEE 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   325 EMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEV-----ALQEAERQKKERERQKEIARQVVERKK-- 397
Cdd:pfam02463  238 RIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLqeeelKLLAKEEEELKSELLKLERRKVDDEEKlk 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   398 --QEEVRRIEKARKKS-------EMEKKERERQQEiARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEE 468
Cdd:pfam02463  318 esEKEKKKAEKELKKEkeeieelEKELKELEIKRE-AEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEE 396

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 597837628   469 EKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLA 516
Cdd:pfam02463  397 LELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQG 444

RIB43A

pfam05914

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...

260-432

2.18e-10

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.

Pssm-ID: 461780 [Multi-domain] Cd Length: 372 Bit Score: 63.38 E-value: 2.18e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  260 MEQLERQRQQEIA-RQVAERQQKEREELEWQQEIARQE--AERQRKEEEMRRQ-----QEYAQQMAEMQRAQKEMEWQRE 331
Cdd:pfam05914 150 QEQMREWLEQQIEeKKQAEEEEKHAELLYDQKRLERDRraLELAKLEEECRRAvnaatKNFNQALAAEQAERRRLEKRQE 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  332 iarQKAEMDEKEKQ---------RQVEIARQMAER----------QRQEEELLRQQEVALQEAERQKK-ERERQKEIARQ 391
Cdd:pfam05914 230 ---QEDNLAEIYNHltsdlltenPEVAQSSLGPHRvipdrwkgmsPEQLKEIRKEQEQQREEKERRREeEKQRDAEWDRQ 306

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 597837628  392 VVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam05914 307 RLELARAALLLEREQQRLRRELRRQLDEENLQLAQEQKARQ 347

DUF4670

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

258-432

3.85e-10

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 63.43 E-value: 3.85e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLE----RQRQQEIARQVAERQQKE---REELEWQQEIARQEAE--RQRKEEEMRRQQEY-AQQMAEMQRAQKEME 327
Cdd:pfam15709 343 AEMRRLEverkRREQEEQRRLQQEQLERAekmREELELEQQRRFEEIRlrKQRLEEERQRQEEEeRKQRLQLQAAQERAR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  328 WQREIARQKAEmdekEKQRQveiaRQMAERQRQEEELLRQQEVALQEAERQKKERERQKEiARQVVERKKQEEVrriEKA 407
Cdd:pfam15709 423 QQQEEFRRKLQ----ELQRK----KQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEE-ERLEYQRQKQEAE---EKA 490

                         170       180
                  ....*....|....*....|....*
gi 597837628  408 RKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam15709 491 RLEAEERRQKEEEAARLALEEAMKQ 515

PTZ00121

MAEBL; Provisional

198-401

4.04e-10

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 64.01 E-value: 4.04e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  198 EDEFLKQLVRIVEAHQVAINKIEEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEmeqlERQRQQEIARQVAE 277
Cdd:PTZ00121 1617 EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE----EAKKAEEDEKKAAE 1692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  278 RQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqreiaRQKAEMDEKEKQRQVEIARQMAER 357
Cdd:PTZ00121 1693 ALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED------KKKAEEAKKDEEEKKKIAHLKKEE 1766

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 597837628  358 QRQEEELLRQQEVALQEaERQKKERERQKEIARQVVERKKQEEV 401
Cdd:PTZ00121 1767 EKKAEEIRKEKEAVIEE-ELDEEDEKRRMEVDKKIKDIFDNFAN 1809

tolA_full

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

261-426

8.37e-10

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 61.40 E-value: 8.37e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRK--EEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAE 338
Cdd:TIGR02794  78 EEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKqaEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAK 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  339 MDEKE--KQRQVEIARQM---------AERQRQEEELLRQQEVALQ--EAERQKKERERQKEIARQVVERKKQE-EVRRI 404
Cdd:TIGR02794 158 AKAAAeaKKKAEEAKKKAeaeakakaeAEAKAKAEEAKAKAEAAKAkaAAEAAAKAEAEAAAAAAAEAERKADEaELGDI 237

                         170       180
                  ....*....|....*....|..
gi 597837628  405 EKARKKSEMEKKERERQQEIAR 426
Cdd:TIGR02794 238 FGLASGSNAEKQGGARGAAAGS 259

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

240-539

9.98e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 62.39 E-value: 9.98e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   240 GSFRKQGPSGNF-----EEGSSNAEMEQLERQR---QQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQE 311
Cdd:TIGR02169  658 GSRAPRGGILFSrsepaELQRLRERLEGLKRELsslQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKE 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   312 yaqQMAEMQRAQKEMEwqREIARQKAEMDEKEKqrqvEIARQmaerqrqeEELLRQQEVALQEAERqKKERERQKEIARQ 391
Cdd:TIGR02169  738 ---RLEELEEDLSSLE--QEIENVKSELKELEA----RIEEL--------EEDLHKLEEALNDLEA-RLSHSRIPEIQAE 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   392 VveRKKQEEVRRIEKARKKSEMEKKERERQQEIA---RQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEE 468
Cdd:TIGR02169  800 L--SKLEEEVSRIEARLREIEQKLNRLTLEKEYLekeIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAAL 877

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628   469 EKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEER--RIEEQLAAREVENQSTVVNPAFGMHIPGET 539
Cdd:TIGR02169  878 RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRlsELKAKLEALEEELSEIEDPKGEDEEIPEEE 950

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

258-518

1.21e-09

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 62.38 E-value: 1.21e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   258 AEMEQLERQ-RQQEIARQVAERQQKEREEL------EWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQR 330
Cdd:TIGR02168  684 EKIEELEEKiAELEKALAELRKELEELEEEleqlrkELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   331 EIARQK-AEMDEKEKQRQVEIARQMAERQRQEEEL--LRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKA 407
Cdd:TIGR02168  764 EELEERlEEAEEELAEAEAEIEELEAQIEQLKEELkaLREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   408 RKKSEmekKERERQQEIARQHAERQRKEEEARRQeearlfAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIE 487
Cdd:TIGR02168  844 EEQIE---ELSEDIESLAAEIEELEELIEELESE------LEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                          250       260       270
                   ....*....|....*....|....*....|....
gi 597837628   488 EERLRKEEEQRIEAQRKAE---EERRIEEQLAAR 518
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGlevRIDNLQERLSEE 948

MAP7

pfam05672

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...

261-378

1.35e-09

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.

Pssm-ID: 461709 [Multi-domain] Cd Length: 153 Bit Score: 57.74 E-value: 1.35e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMD 340
Cdd:pfam05672  25 EQREREEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKE 104

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 597837628  341 EKEKQrqveiARQMAERQRQEEELLRQQEvalqEAERQ 378
Cdd:pfam05672 105 EAEAK-----AREEAERQRQEREKIMQQE----EQERL 133

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

252-430

2.42e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 60.16 E-value: 2.42e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQ---RQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQM------------ 316
Cdd:COG4942   49 EEKALLKQLAALERRiaaLARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLgrqpplalllsp 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 317 AEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIA--RQMAERQRQE-EELLRQQEVALQEAERQKKERErqkEIARQVV 393
Cdd:COG4942  129 EDFLDAVRRLQYLKYLAPARREQAEELRADLAELAalRAELEAERAElEALLAELEEERAALEALKAERQ---KLLARLE 205

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 597837628 394 ERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAE 430
Cdd:COG4942  206 KELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242

PTZ00121

MAEBL; Provisional

304-520

3.14e-09

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 61.31 E-value: 3.14e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  304 EEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAE-MDEKEKQRQVEIARQmAERQRQEEELLRQQEVALQEAERqKKER 382
Cdd:PTZ00121 1085 EDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEaKKKAEDARKAEEARK-AEDARKAEEARKAEDAKRVEIAR-KAED 1162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  383 ERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAErqrkeeearrqeearlfaERQKKERERQEEIA 462
Cdd:PTZ00121 1163 ARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEE------------------ERKAEEARKAEDAK 1224

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  463 RqmeeeekrqreeaeKEEMRKrkieeerlrkeeeqrIEAQRKAEEE-RRIEEQLAAREV 520
Cdd:PTZ00121 1225 K--------------AEAVKK---------------AEEAKKDAEEaKKAEEERNNEEI 1254

tolA_full

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

268-525

3.31e-09

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 59.47 E-value: 3.31e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  268 QQEIARQVAERQQKEreelewqQEIARQEAERQRKEEEMRRQQEyAQQMAEMQRaqkemewQREIARQKAemDEKEKQRQ 347
Cdd:TIGR02794  45 PGAVAQQANRIQQQK-------KPAAKKEQERQKKLEQQAEEAE-KQRAAEQAR-------QKELEQRAA--AEKAAKQA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  348 VEIARQMAERQRQEEELLRQQEvalqeAERQKKererqkeiARQVVERKKQEEvrriekARKKSEMEKKERErqQEIARQ 427
Cdd:TIGR02794 108 EQAAKQAEEKQKQAEEAKAKQA-----AEAKAK--------AEAEAERKAKEE------AAKQAEEEAKAKA--AAEAKK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  428 HAERQRKeeearrqeearlfaeRQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEE 507
Cdd:TIGR02794 167 KAEEAKK---------------KAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADE 231

                         250
                  ....*....|....*...
gi 597837628  508 ERRIEEQLAAREVENQST 525
Cdd:TIGR02794 232 AELGDIFGLASGSNAEKQ 249

PRK12704

phosphodiesterase; Provisional

289-426

4.82e-09

phosphodiesterase; Provisional

Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 59.79 E-value: 4.82e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 289 QQEIARQEAERQRKEEEMRrqqeyaqqmAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEEL---- 364
Cdd:PRK12704  32 KIKEAEEEAKRILEEAKKE---------AEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLdrkl 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628 365 --LRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKAR-------KKSEMEKKERERQQEIAR 426
Cdd:PRK12704 103 elLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISgltaeeaKEILLEKVEEEARHEAAV 173

MAP7

pfam05672

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...

270-400

5.36e-09

Pssm-ID: 461709 [Multi-domain] Cd Length: 153 Bit Score: 55.82 E-value: 5.36e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  270 EIARQVAERQQKERE--ELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQ 347
Cdd:pfam05672  11 EAARILAEKRRQAREqrEREEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQ 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 597837628  348 VEIARQMAERQRQEEELLRQQEvalqEAERQKKERERQKEIARQV-VERKKQEE 400
Cdd:pfam05672  91 REQEEQERLQKQKEEAEAKARE----EAERQRQEREKIMQQEEQErLERKKRIE 140

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

261-426

7.37e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 59.54 E-value: 7.37e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRR-QQEYAQQMAEMQRAQKEMEWQ--REIARQKA 337
Cdd:COG4913   266 AARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERlEARLDALREELDELEAQIRGNggDRLEQLER 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  338 EMDEKEKQRQveiaRQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKE 417
Cdd:COG4913   346 EIERLERELE----ERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRREL 421


                  ....*....
gi 597837628  418 RERQQEIAR 426
Cdd:COG4913   422 RELEAEIAS 430

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

258-432

7.43e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 59.40 E-value: 7.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQqEIARQVAERQQKEREELEWQQEIARQEAERQRKEEE---MRRQQEYAQQMAEMQRAQKEMEwqrEIAR 334
Cdd:COG4717   71 KELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREElekLEKLLQLLPLYQELEALEAELA---ELPE 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 335 QKAEMDEKEKqrqvEIARQMAERQRQEEELLR-QQEVALQEAERQKKERERQKEIARQVveRKKQEEVRRIEKARKKSEM 413
Cdd:COG4717  147 RLEELEERLE----ELRELEEELEELEAELAElQEELEELLEQLSLATEEELQDLAEEL--EELQQRLAELEEELEEAQE 220

                        170
                 ....*....|....*....
gi 597837628 414 EKKERERQQEIARQHAERQ 432
Cdd:COG4717  221 ELEELEEELEQLENELEAA 239

PTZ00121

MAEBL; Provisional

338-519

8.96e-09

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 59.77 E-value: 8.96e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  338 EMDEKEKQRQVEiarqMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKE 417
Cdd:PTZ00121 1080 DFDAKEDNRADE----ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVE 1155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  418 RERQQEIARQhaerqrkeeearrqeearlFAERQKKERERQEEIARQmeeeekrQREEAEKEEMRKrkieeerlrkEEE- 496
Cdd:PTZ00121 1156 IARKAEDARK-------------------AEEARKAEDAKKAEAARK-------AEEVRKAEELRK----------AEDa 1199

                         170       180
                  ....*....|....*....|...
gi 597837628  497 QRIEAQRKAEEERRIEEQLAARE 519
Cdd:PTZ00121 1200 RKAEAARKAEEERKAEEARKAED 1222

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

264-521

1.04e-08

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 59.21 E-value: 1.04e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   264 ERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKE 343
Cdd:pfam02463  647 GLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADR 726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   344 KQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERER---QKEIARQVVERKKQEEVRRIEKARKKSEMEKKERER 420
Cdd:pfam02463  727 VQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSelsLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRAL 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   421 QQE----IARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEE 496
Cdd:pfam02463  807 EEElkeeAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKD 886

                          250       260
                   ....*....|....*....|....*
gi 597837628   497 QRIEAQRKAEEERRIEEQLAAREVE 521
Cdd:pfam02463  887 ELESKEEKEKEEKKELEEESQKLNL 911

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

252-541

1.04e-08

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 59.21 E-value: 1.04e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMA-----EMQRAQKEM 326
Cdd:pfam02463  244 ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKvddeeKLKESEKEK 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   327 EW-QREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIE 405
Cdd:pfam02463  324 KKaEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEE 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   406 KARKKSEMEkkERERQQEIARqhAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRK 485
Cdd:pfam02463  404 EKEAQLLLE--LARQLEDLLK--EEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQL 479

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628   486 IEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQSTVVNPAFGMHIPGETQA 541
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLG 535

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

250-523

1.47e-08

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 58.83 E-value: 1.47e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   250 NFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQ 329
Cdd:pfam02463  740 LLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEE 819

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   330 REIARQKAEMDEKEKQRQVEIARQMAERQRQ--EEELLRQQEVALQEAERQKKERERQKEiarqvverKKQEEVRRIEKA 407
Cdd:pfam02463  820 EQLLIEQEEKIKEEELEELALELKEEQKLEKlaEEELERLEEEITKEELLQELLLKEEEL--------EEQKLKDELESK 891

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   408 RKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKER--------ERQEEIARQMEEEEKRQREEAEKE 479
Cdd:pfam02463  892 EEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEEllleeadeKEKEENNKEEEEERNKRLLLAKEE 971

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 597837628   480 EMRK--RKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:pfam02463  972 LGKVnlMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQ 1017

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

202-517

1.53e-08

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 58.53 E-value: 1.53e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   202 LKQLVRIVEAHQVAINKIEEQVGEERRRggVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQvaERQQK 281
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKE--LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERI--AQLSK 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   282 EREELEWQQEIARQEAERQRkEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKaemdEKEKQRQVEIARQMAERQRQE 361
Cdd:TIGR02168  755 ELTELEAEIEELEERLEEAE-EELAEAEAEIEELEAQIEQLKEELKALREALDEL----RAELTLLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   362 EELLRQQEVALQEAERQKKERERQKEIARQVVErkkqEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQ 441
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQIEELSEDIESLAAEIE----ELEELIEELESELEALLNERASLEEALALLRSELEELSEELRE 905

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628   442 EEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEER--RIEEQLAA 517
Cdd:TIGR02168  906 LESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRlkRLENKIKE 983

TolA

COG3064

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

275-532

1.93e-08

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 57.74 E-value: 1.93e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 275 VAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQmAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQM 354
Cdd:COG3064    1 AQEALEEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEE-ERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 355 AERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRK 434
Cdd:COG3064   80 AEAEKAAAEAEKKAAAEKAKAAKEAEAAAAAEKAAAAAEKEKAEEAKRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 435 EEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQ 514
Cdd:COG3064  160 AAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEA 239

                        250
                 ....*....|....*...
gi 597837628 515 LAAREVENQSTVVNPAFG 532
Cdd:COG3064  240 TEEAALGGAEEAADLAAV 257

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

257-457

2.12e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 57.86 E-value: 2.12e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 257 NAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQK 336
Cdd:COG4717   52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 337 AEMDEKEkqrqveiaRQMAERQRQEEELLRQQEvALQEAERQKKERERQKEIARQVVERKKQ-------EEVRRIEKARK 409
Cdd:COG4717  132 QELEALE--------AELAELPERLEELEERLE-ELRELEEELEELEAELAELQEELEELLEqlslateEELQDLAEELE 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 597837628 410 KSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERER 457
Cdd:COG4717  203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARL 250

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

259-530

2.40e-08

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 58.06 E-value: 2.40e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   259 EMEQLERQRQQEIARQVAERQQKEREELEwQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAE 338
Cdd:pfam02463  713 KKLKLEAEELLADRVQEAQDKINEELKLL-KQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE 791

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   339 MDEKEKQRQVEIARQMAERQRQEEELLRqqevaLQEAERQ--KKERERQKEIARQVVERKKQEEvRRIEKARKKSEMEKK 416
Cdd:pfam02463  792 KEEKLKAQEEELRALEEELKEEAELLEE-----EQLLIEQeeKIKEEELEELALELKEEQKLEK-LAEEELERLEEEITK 865

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   417 ERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEE 496
Cdd:pfam02463  866 EELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEA 945

                          250       260       270
                   ....*....|....*....|....*....|....
gi 597837628   497 QRIEAQRKAEEERRIEEQLAAREVENQSTVVNPA 530
Cdd:pfam02463  946 DEKEKEENNKEEEEERNKRLLLAKEELGKVNLMA 979

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

272-463

2.61e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 58.02 E-value: 2.61e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 272 ARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIA 351
Cdd:COG1196  579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 352 RQ-MAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAE 430
Cdd:COG1196  659 GGsLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738

                        170       180       190
                 ....*....|....*....|....*....|...
gi 597837628 431 RQRKEEEARRQEEARLFAERQKKERERQEEIAR 463
Cdd:COG1196  739 EELLEEEELLEEEALEELPEPPDLEELERELER 771

tolA_full

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

252-410

2.77e-08

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 56.78 E-value: 2.77e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREElewqQEIARQEAERQRKEEEMRRQQEY-AQQMAEMQRAQKemewQR 330
Cdd:TIGR02794  74 EQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQA----EQAAKQAEEKQKQAEEAKAKQAAeAKAKAEAEAERK----AK 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  331 EIARQKAEmDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQ--EAERQKKERERQKEIARQVVERKKQEEVRRIEKAR 408
Cdd:TIGR02794 146 EEAAKQAE-EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAkaKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAE 224


                  ..
gi 597837628  409 KK 410
Cdd:TIGR02794 225 AE 226

tolA

cell envelope integrity inner membrane protein TolA; Provisional

327-526

4.64e-08

cell envelope integrity inner membrane protein TolA; Provisional

Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 56.35 E-value: 4.64e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 327 EWQReIARQKAEMDEKEKQRQVEIARQMAE-RQRQEEELLRQQEVAlQEAERQKKERERQKEIARQVVERKKQEE---VR 402
Cdd:PRK09510  63 QYNR-QQQQQKSAKRAEEQRKKKEQQQAEElQQKQAAEQERLKQLE-KERLAAQEQKKQAEEAAKQAALKQKQAEeaaAK 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 403 RIEKARKKSEMEKKereRQQEIARQHAERQRKEEEARRQEEARlfAERQKKERERQEEIARQMEEEEKRQREEAEKEEMR 482
Cdd:PRK09510 141 AAAAAKAKAEAEAK---RAAAAAKKAAAEAKKKAEAEAAKKAA--AEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEA 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 597837628 483 KRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQSTV 526
Cdd:PRK09510 216 KKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEV 259

DUF4175

pfam13779

Domain of unknown function (DUF4175);

252-427

5.08e-08

Domain of unknown function (DUF4175);

Pssm-ID: 463981 [Multi-domain] Cd Length: 833 Bit Score: 56.92 E-value: 5.08e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  252 EEGSSNAEMEQLE---RQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQ--MAEMQRAQKEM 326
Cdd:pfam13779 503 ERGASDEEIAKLMqelREALDDYMQALAEQAQQNPQDLQQPDDPNAQEMTQQDLQRMLDRIEELARSgrRAEAQQMLSQL 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  327 ewQREIAR-QKAEMDekekQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERE--------RQKEIARQVVERKK 397
Cdd:pfam13779 583 --QQMLENlQAGQPQ----QQQQQGQSEMQQAMDELGDLLREQQQLLDETFRQLQQQGgqqqgqpgQQGQQGQGQQPGQG 656

                         170       180       190
                  ....*....|....*....|....*....|
gi 597837628  398 QEEVRRIEKARKKSEMEKKERERQQEIARQ 427
Cdd:pfam13779 657 GQQPGAQMPPQGGAEALGDLAERQQALRRR 686

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

261-420

7.70e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 56.48 E-value: 7.70e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMD 340
Cdd:COG1196  649 VTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEE 728

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 341 EKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIAR-------------QVVERKK--QEEVRRIE 405
Cdd:COG1196  729 QLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllaieeyeELEERYDflSEQREDLE 808

                        170       180
                 ....*....|....*....|
gi 597837628 406 KARKK-----SEMEKKERER 420
Cdd:COG1196  809 EARETleeaiEEIDRETRER 828

tolA_full

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

203-392

1.04e-07

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 54.85 E-value: 1.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  203 KQLVRIVEAHQVAINKIEEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQKE 282
Cdd:TIGR02794  65 KEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  283 REELEWQQEI---ARQEAERQRKEEEMRRQQEY---AQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAE 356
Cdd:TIGR02794 145 KEEAAKQAEEeakAKAAAEAKKKAEEAKKKAEAeakAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAE 224

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 597837628  357 RQRQEEEL-LRQQEVALQEAERQKKERERQKEIARQV 392
Cdd:TIGR02794 225 AERKADEAeLGDIFGLASGSNAEKQGGARGAAAGSEV 261

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

279-518

1.04e-07

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 55.83 E-value: 1.04e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   279 QQKEREELEwqQEIARQE---AERQRKEEEMRRQQEYAQQMAEMQRAQKEmewqrEIARQKAEMDEKEKQRQVEIARQMA 355
Cdd:TIGR02168  675 RRREIEELE--EKIEELEekiAELEKALAELRKELEELEEELEQLRKELE-----ELSRQISALRKDLARLEAEVEQLEE 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   356 ERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKA---RKKSEMEKKERERQQEIARQHAERQ 432
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKalrEALDELRAELTLLNEEAANLRERLE 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   433 RKEEEARRQEEARLFAERQKKE-RERQEEIARQMEEEEKRQREEAEK-----EEMRKRKIEEERLRKEEEQRIEAQRKAE 506
Cdd:TIGR02168  828 SLERRIAATERRLEDLEEQIEElSEDIESLAAEIEELEELIEELESEleallNERASLEEALALLRSELEELSEELRELE 907

                          250
                   ....*....|..
gi 597837628   507 EERRIEEQLAAR 518
Cdd:TIGR02168  908 SKRSELRRELEE 919

tolA

cell envelope integrity inner membrane protein TolA; Provisional

252-422

1.76e-07

cell envelope integrity inner membrane protein TolA; Provisional

Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 54.43 E-value: 1.76e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQlERQRQQEIARQVAERQQKEREELEWQ-QEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKemewQR 330
Cdd:PRK09510  90 EELQQKQAAEQ-ERLKQLEKERLAAQEQKKQAEEAAKQaALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKK----AA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 331 EIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKK 410
Cdd:PRK09510 165 AEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAA 244

                        170
                 ....*....|..
gi 597837628 411 SEMEKKERERQQ 422
Cdd:PRK09510 245 KAAEKAAAAKAA 256

TolA

COG3064

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

261-559

1.81e-07

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 54.66 E-value: 1.81e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQeyAQQMAEMQRA---QKEMEWQREIARQKA 337
Cdd:COG3064    3 EALEEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQ--AEEEAREAKAeaeQRAAELAAEAAKKLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 338 EMDEKEKQRQVEIARQMAERQRQEEELLRQQEvALQEAERQKKERERQKeiARQVVERKKQEEVRRIEKARKKSEMEKKE 417
Cdd:COG3064   81 EAEKAAAEAEKKAAAEKAKAAKEAEAAAAAEK-AAAAAEKEKAEEAKRK--AEEEAKRKAEEERKAAEAEAAAKAEAEAA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 418 RERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQ 497
Cdd:COG3064  158 RAAAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAV 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597837628 498 RIEAQRKAEEERRIEEQLAAREVENQSTVVNPAFGMHIPGETQAGEHSTDYYGYSTNSDATK 559
Cdd:COG3064  238 EATEEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDD 299

PRK12704

phosphodiesterase; Provisional

269-426

2.21e-07

phosphodiesterase; Provisional

Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 54.40 E-value: 2.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQVAERQQKEREELEWQQEI-ARQEAERQRKEEEmrrqQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQrq 347
Cdd:PRK12704  37 EEEAKRILEEAKKEAEAIKKEALLeAKEEIHKLRNEFE----KELRERRNELQKLEKRLLQKEENLDRKLELLEKREE-- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 348 vEIARQMAERQRQEEELLRQQEVALQEAERQKKERER----QKEIARQVVERKKQEEVRRiEKARKKSEMEKKERERQQE 423
Cdd:PRK12704 111 -ELEKKEKELEQKQQELEKKEEELEELIEEQLQELERisglTAEEAKEILLEKVEEEARH-EAAVLIKEIEEEAKEEADK 188


                 ...
gi 597837628 424 IAR 426
Cdd:PRK12704 189 KAK 191

GumC

COG3206

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

199-402

2.33e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 54.64 E-value: 2.33e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 199 DEFLKQLVRI-VEAHQVAINKIEEQVGEERRRggVEDHEHPAGSFRKQGPSGNFEEGSS---------NAEMEQLERQRQ 268
Cdd:COG3206  159 EAYLEQNLELrREEARKALEFLEEQLPELRKE--LEEAEAALEEFRQKNGLVDLSEEAKlllqqlselESQLAEARAELA 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQVAERQQKEREELEWQ--------QEIARQEAERQRKEEEMRRQqeYAQQMAEMQRAQKEMEWQREIARQKAEMD 340
Cdd:COG3206  237 EAEARLAALRAQLGSGPDALPellqspviQQLRAQLAELEAELAELSAR--YTPNHPDVIALRAQIAALRAQLQQEAQRI 314

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628 341 EKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVER--KKQEEVR 402
Cdd:COG3206  315 LASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESllQRLEEAR 378

PRK00409

recombination and DNA strand exchange inhibitor protein; Reviewed

258-388

2.53e-07

recombination and DNA strand exchange inhibitor protein; Reviewed

Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 54.45 E-value: 2.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMrrQQEYAQQMAEmqrAQKemewqrEIARQKA 337
Cdd:PRK00409 523 ASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEA--EKEAQQAIKE---AKK------EADEIIK 591

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 597837628 338 EMDEKEKQRQVEIARQmaerqrQEEELLRQQEVALQEAE-RQKKERERQKEI 388
Cdd:PRK00409 592 ELRQLQKGGYASVKAH------ELIEARKRLNKANEKKEkKKKKQKEKQEEL 637

DUF4670

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

277-519

3.04e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 54.19 E-value: 3.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  277 ERQQKEREELEWQQ-EIARQEAERQRKE-EEMRRQQEYAQQMAEMQRAQKEMEWQReiarqKAEMDEKEKQRQVEiarqm 354
Cdd:pfam15709 329 EQEKASRDRLRAERaEMRRLEVERKRREqEEQRRLQQEQLERAEKMREELELEQQR-----RFEEIRLRKQRLEE----- 398

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  355 aERQRQEEELLRQqevALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKArkksemeKKERERQQEIARQHAERQRK 434
Cdd:pfam15709 399 -ERQRQEEEERKQ---RLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERA-------EAEKQRQKELEMQLAEEQKR 467

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  435 EEEARRQeearlfaERQKKERERQEEiarqmeeeekrqreeaekEEMRKRKIEEERLRKEeeqriEAQRKAEEERRIEEQ 514
Cdd:pfam15709 468 LMEMAEE-------ERLEYQRQKQEA------------------EEKARLEAEERRQKEE-----EAARLALEEAMKQAQ 517


                  ....*
gi 597837628  515 LAARE 519
Cdd:pfam15709 518 EQARQ 522

CCDC66

pfam15236

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...

313-432

3.24e-07

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.

Pssm-ID: 434558 [Multi-domain] Cd Length: 154 Bit Score: 50.56 E-value: 3.24e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  313 AQQMAE-MQRAQKEMEWQREIarqKAEMDEKEKQRQVEIARQMAERQRQEEELLRQqevalQEAERQKKERERQKEIARQ 391
Cdd:pfam15236  41 PAQLEErERKRQKALEHQNAI---KKQLEEKERQKKLEEERRRQEEQEEEERLRRE-----REEEQKQFEEERRKQKEKE 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 597837628  392 VVERKKQEEVRR-IEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam15236 113 EAMTRKTQALLQaMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154

GBP_C

cd16269

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...

280-424

3.45e-07

Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 52.96 E-value: 3.45e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 280 QKEREELEwqqEIARQEAERQRKEEE-----MRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRqveiarqM 354
Cdd:cd16269  148 LEDREKLV---EKYRQVPRKGVKAEEvlqefLQSKEAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKL-------L 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628 355 AERQRQEEELLRQQEVALQEAERQ---KKERERQKEIARQvveRKKQEEVRRIEKARKKSEMEKKERERQQEI 424
Cdd:cd16269  218 EEQQRELEQKLEDQERSYEEHLRQlkeKMEEERENLLKEQ---ERALESKLKEQEALLEEGFKEQAELLQEEI 287

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

258-535

3.60e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 53.37 E-value: 3.60e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQeiARQVAERQQKEREELEwqQEIARQEAERQRKEEEMRR--------QQEYAQQMAEMQRAQKEME-W 328
Cdd:COG4372   38 FELDKLQEELEQ--LREELEQAREELEQLE--EELEQARSELEQLEEELEElneqlqaaQAELAQAQEELESLQEEAEeL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 329 QREIARQKAEMDEKEKQRQV------EIARQMAERQRQEEELLRQQEVALQEAERQKKERERQ-KEIARQVVERKKQEEV 401
Cdd:COG4372  114 QEELEELQKERQDLEQQRKQleaqiaELQSEIAEREEELKELEEQLESLQEELAALEQELQALsEAEAEQALDELLKEAN 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 402 RRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLF-AERQKKERERQEEIARQMEEEEKRQREEAEKEE 480
Cdd:COG4372  194 RNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLdALELEEDKEELLEEVILKEIEELELAILVEKDT 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 597837628 481 MRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQSTVVNPAFGMHI 535
Cdd:COG4372  274 EEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKL 328

Nop53

pfam07767

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...

309-419

3.92e-07

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.

Pssm-ID: 462259 [Multi-domain] Cd Length: 353 Bit Score: 53.07 E-value: 3.92e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  309 QQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRqveiarqMAERQRQEEELLRQQEVALQEAERQKKER---ERQ 385
Cdd:pfam07767 202 QKAVEAEKKRLKEEEKLERVLEKIAESAATAEAREEKR-------KTKAQRNKEKRRKEEEREAKEEKALKKKLaqlERL 274

                          90       100       110
                  ....*....|....*....|....*....|....
gi 597837628  386 KEIARQVVERKKQEEVRRIEKARKKSEMEKKERE 419
Cdd:pfam07767 275 KEIAKEIAEKEKEREEKAEARKREKRKKKKEEKK 308

rne

PRK10811

ribonuclease E; Reviewed

264-398

4.19e-07

ribonuclease E; Reviewed

Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 53.89 E-value: 4.19e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKEREELEWQQEIARQeaeRQRKEEEMRRQQEYAQQMAEMQRaqkemewqreiaRQKAEMDEKE 343
Cdd:PRK10811  601 ERQQDRRKPRQNNRRDRNERRDTRDNRTRREG---RENREENRRNRRQAQQQTAETRE------------SQQAEVTEKA 665

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628  344 KQRQVEIARQMAERQ--RQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQ 398
Cdd:PRK10811  666 RTQDEQQQAPRRERQrrRNDEKRQAQQEAKALNVEEQSVQETEQEERVQQVQPRRKQ 722

RNase_Y_N

pfam12072

RNase Y N-terminal region;

296-425

4.70e-07

RNase Y N-terminal region;

Pssm-ID: 463456 [Multi-domain] Cd Length: 201 Bit Score: 51.04 E-value: 4.70e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  296 EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQmAERQRQEEELLRQQEVALQEA 375
Cdd:pfam12072  26 EAKIGSAEELAKRIIEEAKKEAETKKKEALLEAKEEIHKLRAEAERELKERRNELQRQ-ERRLLQKEETLDRKDESLEKK 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628  376 ERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSE--------------MEKKERERQQEIA 425
Cdd:pfam12072 105 EESLEKKEKELEAQQQQLEEKEEELEELIEEQRQELErisgltseeakeilLDEVEEELRHEAA 168

DUF4659

pfam15558

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...

264-423

4.96e-07

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.

Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 52.73 E-value: 4.96e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKEREELEWQQEiarqEAERQRKEEEMRRQQEYAQQMaEMQRAQKEMEWQREIARQKAEMDEKE 343
Cdd:pfam15558  19 EEQRMRELQQQAALAWEELRRRDQKRQE----TLERERRLLLQQSQEQWQAEK-EQRKARLGREERRRADRREKQVIEKE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  344 KQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARqvvERKKQEEVRRIEKA-RKKSEMEKKERERQQ 422
Cdd:pfam15558  94 SRWREQAEDQENQRQEKLERARQEAEQRKQCQEQRLKEKEEELQALR---EQNSLQLQERLEEAcHKRQLKEREEQKKVQ 170


                  .
gi 597837628  423 E 423
Cdd:pfam15558 171 E 171

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

197-513

5.52e-07

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 53.82 E-value: 5.52e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   197 SEDEFLKQLVRIVEAHQVAINKIEEQVGEERRRGGVEDhehpaGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEiarQVA 276
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEE-----KSRLKKEEKEEEKSELSLKEKELAEEREKTE---KLK 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   277 ERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEM-DEKEKQRQVEIARQMA 355
Cdd:pfam02463  788 VEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKlAEEELERLEEEITKEE 867

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   356 ERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEvrrIEKARKKSEMEKKERERQQEIARQHAERQRKE 435
Cdd:pfam02463  868 LLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLL---EEKENEIEERIKEEAEILLKYEEEPEELLLEE 944

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   436 EEARRQEEARLFAERQKKER-ERQEEIARQMEEEEKRQREEAEKEEMR----------KRKIEEERLRKEEEQRIEAQRK 504
Cdd:pfam02463  945 ADEKEKEENNKEEEEERNKRlLLAKEELGKVNLMAIEEFEEKEERYNKdelekerleeEKKKLIRAIIEETCQRLKEFLE 1024


                   ....*....
gi 597837628   505 AEEERRIEE 513
Cdd:pfam02463 1025 LFVSINKGW 1033

YqiK

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

355-517

5.84e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 52.95 E-value: 5.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 355 AERQRQEEELLRQQEVALQEAER----QKKERERQKEIARqvVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAE 430
Cdd:COG2268  188 ALGRRKIAEIIRDARIAEAEAEReteiAIAQANREAEEAE--LEQEREIETARIAEAEAELAKKKAEERREAETARAEAE 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 431 RQRKEEearrqeearlfAERQKKERERQEEIARQmeeeekrQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEER- 509
Cdd:COG2268  266 AAYEIA-----------EANAEREVQRQLEIAER-------EREIELQEKEAEREEAELEADVRKPAEAEKQAAEAEAEa 327

                        170
                 ....*....|.
gi 597837628 510 ---RIEEQLAA 517
Cdd:COG2268  328 eaeAIRAKGLA 338

GBP_C

cd16269

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...

261-381

6.09e-07

Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 52.19 E-value: 6.09e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 261 EQLER--QRQQEIARQV--AERQQKEREELEWQQEIARQEAERQRK-EEEMRRQQEyaQQMAEMQRAQKEMewqreIARQ 335
Cdd:cd16269  170 EVLQEflQSKEAEAEAIlqADQALTEKEKEIEAERAKAEAAEQERKlLEEQQRELE--QKLEDQERSYEEH-----LRQL 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 597837628 336 KAEMdEKEKQRQVEIARQMAERQRQEEELLrQQEVALQEAERQKKE 381
Cdd:cd16269  243 KEKM-EEERENLLKEQERALESKLKEQEAL-LEEGFKEQAELLQEE 286

sbcc

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

266-523

7.58e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 53.05 E-value: 7.58e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   266 QRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEM----RRQQEYAQQMAEMQRAQKEMEWQR------EIARQ 335
Cdd:TIGR00618  222 QVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLkqlrARIEELRAQEAVLEETQERINRARkaaplaAHIKA 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   336 KAEMDEKEKQRQVEIARQMAER---------------------------QRQEEELLRQQEVAL---QEAERQKKERER- 384
Cdd:TIGR00618  302 VTQIEQQAQRIHTELQSKMRSRakllmkraahvkqqssieeqrrllqtlHSQEIHIRDAHEVATsirEISCQQHTLTQHi 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   385 -----QKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQrkeeearrQEEARLFAERQKKERERQE 459
Cdd:TIGR00618  382 htlqqQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQE--------LQQRYAELCAAAITCTAQC 453

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 597837628   460 EIARQMEEEEKRQREEAEKEEMR-KRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:TIGR00618  454 EKLEKIHLQESAQSLKEREQQLQtKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQ 518

DUF4659

pfam15558

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...

299-431

7.76e-07

Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 52.35 E-value: 7.76e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  299 RQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELL--RQQEVALQE-- 374
Cdd:pfam15558  16 RHKEEQRMRELQQQAALAWEELRRRDQKRQETLERERRLLLQQSQEQWQAEKEQRKARLGREERRRAdrREKQVIEKEsr 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628  375 ----AERQKKERERQKEIARQVVERKKQEEVRRIekaRKKSEMEKKERERQQEIARQHAER 431
Cdd:pfam15558  96 wreqAEDQENQRQEKLERARQEAEQRKQCQEQRL---KEKEEELQALREQNSLQLQERLEE 153

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

253-530

8.49e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 52.21 E-value: 8.49e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 253 EGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMA-EMQRAQKEMEWQRE 331
Cdd:COG4372   22 TGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNeQLQAAQAELAQAQE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 ----IARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKA 407
Cdd:COG4372  102 elesLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 408 RKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIE 487
Cdd:COG4372  182 EQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIE 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 597837628 488 EERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQSTVVNPA 530
Cdd:COG4372  262 ELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNL 304

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

237-427

8.54e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 53.00 E-value: 8.54e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  237 HPAGSFRKQGPSGNFEE---GSSNaemeqleRQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYA 313
Cdd:COG4913   585 GNGTRHEKDDRRRIRSRyvlGFDN-------RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYS 657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  314 QQMAEMQRAQKEM-EWQREIARQKAEMDE-KEKQRQVEIARQMAERQRQEEELLRQQEVALQEA-ERQKKERERQKEIAR 390
Cdd:COG4913   658 WDEIDVASAEREIaELEAELERLDASSDDlAALEEQLEELEAELEELEEELDELKGEIGRLEKElEQAEEELDELQDRLE 737

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 597837628  391 QVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQ 427
Cdd:COG4913   738 AAEDLARLELRALLEERFAAALGDAVERELRENLEER 774

PRK00409

recombination and DNA strand exchange inhibitor protein; Reviewed

332-461

1.14e-06

recombination and DNA strand exchange inhibitor protein; Reviewed

Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 52.52 E-value: 1.14e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 IARQKAEM-DEKEKQRQVeIARQMAERQRQEEELlRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARK- 409
Cdd:PRK00409 504 IEEAKKLIgEDKEKLNEL-IASLEELERELEQKA-EEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKe 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628 410 -KSEME---KKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEI 461
Cdd:PRK00409 582 aKKEADeiiKELRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQEEL 637

Borrelia_P83

pfam05262

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

243-430

1.17e-06

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

Pssm-ID: 114011 [Multi-domain] Cd Length: 489 Bit Score: 51.93 E-value: 1.17e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  243 RKQGPSGNFeegsSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAER---QRKEEEMRRQQEYAQQMAEM 319
Cdd:pfam05262 161 KKNILSGNV----SDVDTDSISDKKVVEALREDNEKGVNFRRDMTDLKERESQEDAKraqQLKEELDKKQIDADKAQQKA 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  320 QRAQKEMEWQREIARQKaemdEKEKQRQVEIARQMAERQRQeeellrqqevalQEAERQKKERER-QKEIARQVVERKKQ 398
Cdd:pfam05262 237 DFAQDNADKQRDEVRQK----QQEAKNLPKPADTSSPKEDK------------QVAENQKREIEKaQIEIKKNDEEALKA 300

                         170       180       190
                  ....*....|....*....|....*....|..
gi 597837628  399 EEVRRIEKARKKSEMEKKERERQQEIARQHAE 430
Cdd:pfam05262 301 KDHKAFDLKQESKASEKEAEDKELEAQKKREP 332

Nup88

pfam10168

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...

268-430

1.21e-06

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.

Pssm-ID: 462975 [Multi-domain] Cd Length: 713 Bit Score: 52.35 E-value: 1.21e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  268 QQEIARQVAERQQKEREELEWQQEIARQEAERQRKeeeMRRQQEyAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQ 347
Cdd:pfam10168 530 PQECLQLLSRATQVFREEYLKKHDLAREEIQKRVK---LLKLQK-EQQLQELQSLEEERKSLSERAEKLAEKYEEIKDKQ 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  348 VEIARQMAERQRqeeeLLRQQEVALQEAERQ-KKERERQKEIARQVVER-----KKQEEVRR-IEK---ARKKSEMEKKE 417
Cdd:pfam10168 606 EKLMRRCKKVLQ----RLNSQLPVLSDAEREmKKELETINEQLKHLANAikqakKKMNYQRYqIAKsqsIRKKSSLSLSE 681

                         170
                  ....*....|....*
gi 597837628  418 RERQ--QEIARQHAE 430
Cdd:pfam10168 682 KQRKtiKEILKQLGS 696

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

254-463

1.50e-06

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 52.38 E-value: 1.50e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   254 GSSNAEMEQLERQrqqeIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQ-EYAQQMAEMQRAQKEMEWQR-- 330
Cdd:TIGR02169  297 GELEAEIASLERS----IAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERkRRDKLTEEYAELKEELEDLRae 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   331 --EIARQKAEMDEKEKQRQVEIarqmAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKAr 408
Cdd:TIGR02169  373 leEVDKEFAETRDELKDYREKL----EKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKA- 447

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 597837628   409 kkSEMEKKERERQQEIARQHAERQRKEEEARRqeearlFAERQKKERERQEEIAR 463
Cdd:TIGR02169  448 --LEIKKQEWKLEQLAADLSKYEQELYDLKEE------YDRVEKELSKLQRELAE 494

CCDC34

pfam13904

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...

280-410

1.61e-06

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.

Pssm-ID: 464032 [Multi-domain] Cd Length: 221 Bit Score: 50.09 E-value: 1.61e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  280 QKEREELE-WQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEM---EWQREIARQKAEMDEKEKQRQVEIARQMA 355
Cdd:pfam13904  48 KLERQPLEaYENWLAAKQRQRQKELQAQKEEREKEEQEAELRKRLAKEkyqEWLQRKARQQTKKREESHKQKAAESASKS 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628  356 ERQRQEEELLRQQEVALQEAERQKKERE-RQKEIARQVVERKKQEEVRRIEKARKK 410
Cdd:pfam13904 128 LAKPERKVSQEEAKEVLQEWERKKLEQQqRKREEEQREQLKKEEEEQERKQLAEKA 183

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

262-463

1.65e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 51.86 E-value: 1.65e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 262 QLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDE 341
Cdd:COG1196  578 PLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGS 657

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 342 KEKQRQVEIARQMAERQRQEEELLRQQEVALQEAER-QKKERERQKEIARQVVERKKQEEVRRIEKARKKsemEKKERER 420
Cdd:COG1196  658 AGGSLTGGSRRELLAALLEAEAELEELAERLAEEELeLEEALLAEEEEERELAEAEEERLEEELEEEALE---EQLEAER 734

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 597837628 421 QQEIARQHAERQRKEEEARRQEEARLFAERQKKERER-QEEIAR 463
Cdd:COG1196  735 EELLEELLEEEELLEEEALEELPEPPDLEELERELERlEREIEA 778

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

258-427

1.90e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 51.84 E-value: 1.90e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQE---AERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIAR 334
Cdd:COG4913   286 AQRRLELLEAELEELRAELARLEAELERLEARLDALREEldeLEAQIRGNGGDRLEQLEREIERLERELEERERRRARLE 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  335 QKAEM-------DEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEiarqvverkkqEEVRRIEka 407
Cdd:COG4913   366 ALLAAlglplpaSAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELE-----------AEIASLE-- 432

                         170       180
                  ....*....|....*....|
gi 597837628  408 RKKSEMEKKERERQQEIARQ 427
Cdd:COG4913   433 RRKSNIPARLLALRDALAEA 452

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

259-523

1.97e-06

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 51.99 E-value: 1.97e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   259 EMEQLERQRQ-----QEIARQVAERQQKE--REELEWQQEIARQEAERQRKEEEMRRQQEYAQQMA-EMQRAQKEMEwqr 330
Cdd:TIGR02169  199 QLERLRREREkaeryQALLKEKREYEGYEllKEKEALERQKEAIERQLASLEEELEKLTEEISELEkRLEEIEQLLE--- 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   331 EIARQKAEMDEKEkqrQVEIARQMAERQRQEEELLRQQEVALQE----AERQKKERERQKEIARQVVERKKQEEVRRIEK 406
Cdd:TIGR02169  276 ELNKKIKDLGEEE---QLRVKEKIGELEAEIASLERSIAEKEREledaEERLAKLEAEIDKLLAEIEELEREIEEERKRR 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   407 ARKKSEMEKKERERQ------QEIARQHAERQrkeeearrqeearlfaERQKKERERQEEIARQMeeeEKRQREEAEKEE 480
Cdd:TIGR02169  353 DKLTEEYAELKEELEdlraelEEVDKEFAETR----------------DELKDYREKLEKLKREI---NELKRELDRLQE 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 597837628   481 MRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:TIGR02169  414 ELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWK 456

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

295-464

2.11e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 51.31 E-value: 2.11e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 295 QEAERQRKEEEmRRQQEYAQQMAEMQRAQKEME-WQREIARQKAEMDEKEKQRQveiARQMAERQRQEEELLRQQEVALQ 373
Cdd:COG4717   74 KELEEELKEAE-EKEEEYAELQEELEELEEELEeLEAELEELREELEKLEKLLQ---LLPLYQELEALEAELAELPERLE 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 374 EAERQKKE-RERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQK 452
Cdd:COG4717  150 ELEERLEElRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229

                        170
                 ....*....|..
gi 597837628 453 KERERQEEIARQ 464
Cdd:COG4717  230 EQLENELEAAAL 241

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

259-383

2.27e-06

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 50.69 E-value: 2.27e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEyAQQMAEMQRAQKEMEWQREIARQkae 338
Cdd:pfam13868 223 EREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEE-IEQEEAEKRRMKRLEHRRELEKQ--- 298

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 597837628  339 mdEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERE 383
Cdd:pfam13868 299 --IEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKKLKE 341

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

265-527

3.64e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 50.29 E-value: 3.64e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEREELE-WQQEIARQEAERQRKEEEMRRQQEyaqqmaEMQRAQKEMEWQREIARQKAEMDEKE 343
Cdd:COG4372   19 RPKTGILIAALSEQLRKALFELDkLQEELEQLREELEQAREELEQLEE------ELEQARSELEQLEEELEELNEQLQAA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 344 KQRQVEIARQMAERQRQEEELlrqqevaLQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQE 423
Cdd:COG4372   93 QAELAQAQEELESLQEEAEEL-------QEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 424 IARQHAERQRKEEEARRQEEARLFAE-RQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQ 502
Cdd:COG4372  166 LAALEQELQALSEAEAEQALDELLKEaNRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245

                        250       260
                 ....*....|....*....|....*
gi 597837628 503 RKAEEERRIEEQLAAREVENQSTVV 527
Cdd:COG4372  246 EDKEELLEEVILKEIEELELAILVE 270

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

196-484

3.95e-06

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 50.84 E-value: 3.95e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   196 MSEDefLKQLVRIVEAHQVAINKIEEQVGEERRRggVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQ------ 269
Cdd:TIGR02169  679 LRER--LEGLKRELSSLQSELRRIENRLDELSQE--LSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSleqeie 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   270 ----EIARQVAERQQKEREELEWQQEIARQEAER-----QRKEEEMRRQQEYAQ----QMAEMQRAQKEMEWQREIARQK 336
Cdd:TIGR02169  755 nvksELKELEARIEELEEDLHKLEEALNDLEARLshsriPEIQAELSKLEEEVSrieaRLREIEQKLNRLTLEKEYLEKE 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   337 AEmdeKEKQRQVEIARQMAERQRQEEEL-LRQQEVALQEAERQKKERE---RQKEIARQVVERKKQEEVRRIEKARKKSE 412
Cdd:TIGR02169  835 IQ---ELQEQRIDLKEQIKSIEKEIENLnGKKEELEEELEELEAALRDlesRLGDLKKERDELEAQLRELERKIEELEAQ 911

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   413 MEKKE-RERQQEIARQHAE----------RQRKEEEARRQEEARLFAERQKKERERQ--------------EEIARQMEE 467
Cdd:TIGR02169  912 IEKKRkRLSELKAKLEALEeelseiedpkGEDEEIPEEELSLEDVQAELQRVEEEIRalepvnmlaiqeyeEVLKRLDEL 991

                          330
                   ....*....|....*..
gi 597837628   468 EEKRQREEAEKEEMRKR 484
Cdd:TIGR02169  992 KEKRAKLEEERKAILER 1008

PKK

pfam12474

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...

274-405

4.15e-06

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.

Pssm-ID: 463600 [Multi-domain] Cd Length: 139 Bit Score: 47.17 E-value: 4.15e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  274 QVAERQQKEREELEWQQEIARQEAERqrkeEEMRRQQEyaQQMAEMQRAQkEMEWQREIARQKAEMDEKEKQRQVEIARQ 353
Cdd:pfam12474   2 QLQKEQQKDRFEQERQQLKKRYEKEL----EQLERQQK--QQIEKLEQRQ-TQELRRLPKRIRAEQKKRLKMFRESLKQE 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 597837628  354 MAERqRQEEELLRQQEvaLQEAERQKKERERQKEIARQVVERKKQEEVRRIE 405
Cdd:pfam12474  75 KKEL-KQEVEKLPKFQ--RKEAKRQRKEELELEQKHEELEFLQAQSEALERE 123

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

258-512

4.45e-06

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 50.84 E-value: 4.45e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   258 AEMEQLERQRQQ---EIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRR--QQEYAQQMAEMQRAQKEMEW---- 328
Cdd:TIGR02169  230 KEKEALERQKEAierQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDlgEEEQLRVKEKIGELEAEIASlers 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   329 QREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQ--EVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEK 406
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERkrRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKD 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   407 ARKKSEMEKKERE-------RQQEIARQHAERQRKEEEARRQEEARL--FAERQKKERERQEEIARQMEEEEKRQREEAE 477
Cdd:TIGR02169  390 YREKLEKLKREINelkreldRLQEELQRLSEELADLNAAIAGIEAKIneLEEEKEDKALEIKKQEWKLEQLAADLSKYEQ 469

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 597837628   478 KEEMRKRKIEE----ERLRKEEEQRIEAQRKAEEERRIE 512
Cdd:TIGR02169  470 ELYDLKEEYDRvekeLSKLQRELAEAEAQARASEERVRG 508

OmpH

pfam03938

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

314-409

5.27e-06

Pssm-ID: 461098 [Multi-domain] Cd Length: 140 Bit Score: 46.80 E-value: 5.27e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  314 QQMAEMQRAQKEME-----WQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEI 388
Cdd:pfam03938  12 EESPEGKAAQAQLEkkfkkRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQE 91

                          90       100
                  ....*....|....*....|.
gi 597837628  389 ARQVVERKKQEEVRRIEKARK 409
Cdd:pfam03938  92 LLQPIQDKINKAIKEVAKEKG 112

CwlO1

COG3883

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

255-432

5.32e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 49.83 E-value: 5.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 255 SSNAEMEQLERQRQQeiARQVAERQQKEREELewQQEIARQEAERQRKEEEMrrqqeyAQQMAEMQRAQKEMEW------ 328
Cdd:COG3883   41 ALQAELEELNEEYNE--LQAELEALQAEIDKL--QAEIAEAEAEIEERREEL------GERARALYRSGGSVSYldvllg 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 329 --------------QREIARQKAEMDE-KEKQRQVEIARQMAERQRQE-EELLRQQEVALQEAERQKKERERQ-KEIARQ 391
Cdd:COG3883  111 sesfsdfldrlsalSKIADADADLLEElKADKAELEAKKAELEAKLAElEALKAELEAAKAELEAQQAEQEALlAQLSAE 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 597837628 392 VVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:COG3883  191 EAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

255-464

5.52e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.76 E-value: 5.52e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 255 SSNAEMEQLERQR---QQEIARQVAERQQKEREELEWQQEIARQEAERQRKEeemRRQQEYAQQMAEMQRAQKEMewQRE 331
Cdd:COG4942   17 AQADAAAEAEAELeqlQQEIAELEKELAALKKEEKALLKQLAALERRIAALA---RRIRALEQELAALEAELAEL--EKE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 IARQKAEMDEKEKQ-RQVEIARQMAERQRQEEELLRQQEVAlqeaerqkkERERQKEIARQVVERKKQeevrRIEKARKK 410
Cdd:COG4942   92 IAELRAELEAQKEElAELLRALYRLGRQPPLALLLSPEDFL---------DAVRRLQYLKYLAPARRE----QAEELRAD 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 597837628 411 SEmEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQ 464
Cdd:COG4942  159 LA-ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAEL 211

PRK00409

recombination and DNA strand exchange inhibitor protein; Reviewed

318-423

6.11e-06

recombination and DNA strand exchange inhibitor protein; Reviewed

Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 50.21 E-value: 6.11e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 318 EMQRAQKEMEWQR-EIARQKAEmdeKEKQrqvEIARQMAERQRQEEELLRQQEVALQEAERQKKE---------RERQKE 387
Cdd:PRK00409 526 EELERELEQKAEEaEALLKEAE---KLKE---ELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKeadeiikelRQLQKG 599

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 597837628 388 IARQVVERKKQEEVRRIEKARKKSEMEKKERERQQE 423
Cdd:PRK00409 600 GYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQE 635

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

288-521

6.24e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.38 E-value: 6.24e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 288 WQQEIARQEAERQRKEeemrRQQEYAQQMAEMQRAQKEmewQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELlrq 367
Cdd:COG4942   16 AAQADAAAEAEAELEQ----LQQEIAELEKELAALKKE---EKALLKQLAALERRIAALARRIRALEQELAALEAEL--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 368 QEVALQEAERQKKERERQKEIARQVVERKKQEEVRRI----------EKARKKSEMEKKERERQQEIARQHAERQRKEEE 437
Cdd:COG4942   86 AELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLalllspedflDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 438 ARRqeearLFAERQKKERERQEEIARQmeeeekrQREEAEKEEmrKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAA 517
Cdd:COG4942  166 RAE-----LEAERAELEALLAELEEER-------AALEALKAE--RQKLLARLEKELAELAAELAELQQEAEELEALIAR 231


                 ....
gi 597837628 518 REVE 521
Cdd:COG4942  232 LEAE 235

PRK10929

putative mechanosensitive channel protein; Provisional

259-416

6.85e-06

putative mechanosensitive channel protein; Provisional

Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 50.05 E-value: 6.85e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQE--AERQRK-EEEMRRQQEYAQQMAEMQRA-QKEMEWQREIAR 334
Cdd:PRK10929  193 ELAQLSANNRQELARLRSELAKKRSQQLDAYLQALRNQlnSQRQREaERALESTELLAEQSGDLPKSiVAQFKINRELSQ 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  335 ----QKAEMDE-KEKQRQveiARQMAERQRQEEELLRQQ------EVALQEAERQKKER--ERQK------EIARQVVER 395
Cdd:PRK10929  273 alnqQAQRMDLiASQQRQ---AASQTLQVRQALNTLREQsqwlgvSNALGEALRAQVARlpEMPKpqqldtEMAQLRVQR 349

                         170       180
                  ....*....|....*....|.
gi 597837628  396 KKQEEVrrIEKARKKSEMEKK 416
Cdd:PRK10929  350 LRYEDL--LNKQPQLRQIRQA 368

PRK10929

putative mechanosensitive channel protein; Provisional

208-432

7.09e-06

putative mechanosensitive channel protein; Provisional

Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 50.05 E-value: 7.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  208 IVEAHQVAINKIEEQVGEERR----RGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEM--EQLERQRQQ------EIARQV 275
Cdd:PRK10929   46 IVEALQSALNWLEERKGSLERakqyQQVIDNFPKLSAELRQQLNNERDEPRSVPPNMstDALEQEILQvssqllEKSRQA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  276 AERQQKERE------ELEWQQEiarqEAERQRKEEEMRRQQEYAQQ--MAEMQRAQKemewQREIARQKAEMDEKE---- 343
Cdd:PRK10929  126 QQEQDRAREisdslsQLPQQQT----EARRQLNEIERRLQTLGTPNtpLAQAQLTAL----QAESAALKALVDELElaql 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  344 --KQRQvEIARQMAE-RQRQEEEL-LRQQEVALQEAERQKKERERQKEIARQVVERKKQ---EEVRRIEKARKKSEMEKK 416
Cdd:PRK10929  198 saNNRQ-ELARLRSElAKKRSQQLdAYLQALRNQLNSQRQREAERALESTELLAEQSGDlpkSIVAQFKINRELSQALNQ 276

                         250
                  ....*....|....*.
gi 597837628  417 ERERQQEIARQhaERQ 432
Cdd:PRK10929  277 QAQRMDLIASQ--QRQ 290

DUF4659

pfam15558

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...

258-464

7.69e-06

Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 49.26 E-value: 7.69e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMR-RQQEYA-QQMAEMQRAQKEMEWQR----- 330
Cdd:pfam15558  72 ARLGREERRRADRREKQVIEKESRWREQAEDQENQRQEKLERARQEAEQRkQCQEQRlKEKEEELQALREQNSLQlqerl 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  331 EIARQKAEMDEKEKQRQV------EIARQMA-----ERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVER--KK 397
Cdd:pfam15558 152 EEACHKRQLKEREEQKKVqennlsELLNHQArkvlvDCQAKAEELLRRLSLEQSLQRSQENYEQLVEERHRELREKaqKE 231

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 597837628  398 QEEVRRIEKARKKSEMEKKER--------ERQQEIARQHAERQRKEEEARrqeearlfAERQKKERERQEEIARQ 464
Cdd:pfam15558 232 EEQFQRAKWRAEEKEEERQEHkealaelaDRKIQQARQVAHKTVQDKAQR--------ARELNLEREKNHHILKL 298

CwlO1

COG3883

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

265-462

7.88e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 49.06 E-value: 7.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEyaqqmaEMQRAQKE-MEWQREIARQKAEMDE-- 341
Cdd:COG3883   19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQA------EIDKLQAEiAEAEAEIEERREELGEra 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 342 KEKQRQ----------------------VEIARQMAERQRqeeELLRQQEVALQEAERQKKERERQKEIARQVV----ER 395
Cdd:COG3883   93 RALYRSggsvsyldvllgsesfsdfldrLSALSKIADADA---DLLEELKADKAELEAKKAELEAKLAELEALKaeleAA 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628 396 KKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIA 462
Cdd:COG3883  170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

258-426

7.94e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.94 E-value: 7.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEM-----RRQQEYAQQMAEMQRAQKEMEWQREI 332
Cdd:COG1196  605 ASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGeggsaGGSLTGGSRRELLAALLEAEAELEEL 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 333 ARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSE 412
Cdd:COG1196  685 AERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEE 764

                        170
                 ....*....|....
gi 597837628 413 MEKKERERQQEIAR 426
Cdd:COG1196  765 LERELERLEREIEA 778

MAP7

pfam05672

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...

343-464

7.98e-06

Pssm-ID: 461709 [Multi-domain] Cd Length: 153 Bit Score: 46.57 E-value: 7.98e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  343 EKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQ 422
Cdd:pfam05672  18 EKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQE 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 597837628  423 EIARQHAERQRKEEEArrqeearlfAERQKKERER---QEEIARQ 464
Cdd:pfam05672  98 RLQKQKEEAEAKAREE---------AERQRQEREKimqQEEQERL 133

HlpA

COG2825

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...

314-424

8.21e-06

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 442073 [Multi-domain] Cd Length: 171 Bit Score: 47.14 E-value: 8.21e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 314 QQMAEMQRAQKEMEwqreiarqkaemdEKEKQRQVEIARQMAERQRQEEELLRQQEVaLQEAERQKKERErqkeIarqvv 393
Cdd:COG2825   36 QESPEGKAAQKKLE-------------KEFKKRQAELQKLEKELQALQEKLQKEAAT-LSEEERQKKERE----L----- 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 597837628 394 eRKKQEEVRRIEKARKKsEMEKKERERQQEI 424
Cdd:COG2825   93 -QKKQQELQRKQQEAQQ-DLQKRQQELLQPI 121

TolA

COG3064

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

258-564

8.50e-06

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 49.27 E-value: 8.50e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIARQVAERQQKEREE--LEWQQEIARQEAERQRKEEEMRRQQEyAQQMAEMQRAQKEMEWQREIARQ 335
Cdd:COG3064   39 AEEERLAELEAKRQAEEEAREAKAEAEQraAELAAEAAKKLAEAEKAAAEAEKKAA-AEKAKAAKEAEAAAAAEKAAAAA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 336 KAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEK 415
Cdd:COG3064  118 EKEKAEEAKRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAA 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 416 KERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEE 495
Cdd:COG3064  198 AAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSG 277

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628 496 EQRIEAQRKAEEERRIEEQLAAREVENQSTVVNPAFGMHIPGETQAGEHSTDYYGYSTNSDATKTVLAG 564
Cdd:COG3064  278 LVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAAAAAAGALVVRGGGAASLEAALSLLAA 346

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

304-464

8.68e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 49.53 E-value: 8.68e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  304 EEMRRQQEYAQQMAEMQRAQKEMEWQREIARQkaemdEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERE 383
Cdd:COG4913   245 EDAREQIELLEPIRELAERYAAARERLAELEY-----LRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLD 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  384 RQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEiARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIAR 463
Cdd:COG4913   320 ALREELDELEAQIRGNGGDRLEQLEREIERLERELEERER-RRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEE 398


                  .
gi 597837628  464 Q 464
Cdd:COG4913   399 E 399

vATP-synt_E

pfam01991

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...

259-416

9.47e-06

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.

Pssm-ID: 396537 [Multi-domain] Cd Length: 199 Bit Score: 47.37 E-value: 9.47e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQKEREELEWQQEIA-RQEAERQRKEEEMRRQQEYAQQMAEMQRaqKEMEWQREIARqka 337
Cdd:pfam01991   1 FIRQEAEEKAEEIRAKAEEEFAIEKAELVQEAEEKiDEIYEKKEKQAEMQKKIIISNAKNEARL--KVLEAREEILD--- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  338 EMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEevrrIEKARKKSEMEKK 416
Cdd:pfam01991  76 EVFNEAEKKLAELEEDTDEYKDLLRKLIVQALVKLGEPEVIVRCRKRDEELVESALDKAAEE----YKAKTKKVTVEKA 150

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

257-410

1.14e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 49.14 E-value: 1.14e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  257 NAEMEQLERQRQQEIARQVAERQQKER--EELEW---QQEIARQEAERQRKE------EEMRRQQEYAQqmAEMQRAQKE 325
Cdd:COG4913   630 EERLEALEAELDALQERREALQRLAEYswDEIDVasaEREIAELEAELERLDassddlAALEEQLEELE--AELEELEEE 707

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  326 mewQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEvRRIE 405
Cdd:COG4913   708 ---LDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALR-ARLN 783


                  ....*
gi 597837628  406 KARKK 410
Cdd:COG4913   784 RAEEE 788

ATP-synt_Fo_b

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...

266-357

1.16e-05

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.

Pssm-ID: 349951 [Multi-domain] Cd Length: 132 Bit Score: 45.51 E-value: 1.16e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 266 QRQQEIARQV--AERQQKEREEL--EWQQEI--ARQEAERQRKEEEMRRQQEYAQQMAEMQR-AQKEME-WQREIARQKA 337
Cdd:cd06503   30 EREEKIAESLeeAEKAKEEAEELlaEYEEKLaeARAEAQEIIEEARKEAEKIKEEILAEAKEeAERILEqAKAEIEQEKE 109

                         90       100
                 ....*....|....*....|
gi 597837628 338 EMDEKEKQRQVEIARQMAER 357
Cdd:cd06503  110 KALAELRKEVADLAVEAAEK 129

DR0291

COG1579

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

290-432

1.39e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 47.23 E-value: 1.39e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 290 QEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEmEWQREIARQKAEMDEKEKQRQVEIARQMAER-QRQEEELlrQQ 368
Cdd:COG1579   20 DRLEHRLKELPAELAELEDELAALEARLEAAKTELE-DLEKEIKRLELEIEEVEARIKKYEEQLGNVRnNKEYEAL--QK 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628 369 EVALQEAERQKKErERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:COG1579   97 EIESLKRRISDLE-DEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159

ERM_helical

pfam20492

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...

261-369

1.58e-05

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.

Pssm-ID: 466641 [Multi-domain] Cd Length: 120 Bit Score: 44.91 E-value: 1.58e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIAR--QVAERQQKEREELEWQQEIARQ-EAERQRKEEEMRRQQEYAQQMAEMQR-----AQKEMEWQREI 332
Cdd:pfam20492   2 EEAEREKQELEERlkQYEEETKKAQEELEESEETAEElEEERRQAEEEAERLEQKRQEAEEEKErleesAEMEAEEKEQL 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 597837628  333 ARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQE 369
Cdd:pfam20492  82 EAELAEAQEEIARLEEEVERKEEEARRLQEELEEARE 118

PRK12705

hypothetical protein; Provisional

265-430

1.62e-05

hypothetical protein; Provisional

Pssm-ID: 237178 [Multi-domain] Cd Length: 508 Bit Score: 48.55 E-value: 1.62e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEREELEWQQEIARQE---AERQRKEEEMRRQQEyaqqmaEMQRAQKEMEWQREIARQKAEMDE 341
Cdd:PRK12705  28 RQRLAKEAERILQEAQKEAEEKLEAALLEAKElllRERNQQRQEARRERE------ELQREEERLVQKEEQLDARAEKLD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 342 KEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKErERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQ 421
Cdd:PRK12705 102 NLENQLEEREKALSARELELEELEKQLDNELYRVAGLTPE-QARKLLLKLLDAELEEEKAQRVKKIEEEADLEAERKAQN 180

                        170
                 ....*....|..
gi 597837628 422 ---QEIARQHAE 430
Cdd:PRK12705 181 ilaQAMQRIASE 192

CCDC50_N

pfam15295

Coiled-coil domain-containing protein 50 N-terminus;

329-403

1.63e-05

Coiled-coil domain-containing protein 50 N-terminus;

Pssm-ID: 464621 [Multi-domain] Cd Length: 126 Bit Score: 45.10 E-value: 1.63e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628  329 QREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQ-QEVALQEAERQKKERERQKEIARQVVERKKQEEVRR 403
Cdd:pfam15295  50 QNDIRVAKQLQEEEELQAQTLFQRRLAQLEEQDEEIAKEiQEELQREAEERRRREEEDEEIARQLQERERERERRR 125

hsdR

PRK11448

type I restriction enzyme EcoKI subunit R; Provisional

261-367

1.68e-05

type I restriction enzyme EcoKI subunit R; Provisional

Pssm-ID: 236912 [Multi-domain] Cd Length: 1123 Bit Score: 48.79 E-value: 1.68e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEeemrrqqeyaQQMAEMQRAQKEMEWQREIARQKAEMD 340
Cdd:PRK11448  141 ENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALE----------GLAAELEEKQQELEAQLEQLQEKAAET 210

                          90       100
                  ....*....|....*....|....*...
gi 597837628  341 EKE-KQRQVEIARQMAERQRQEEELLRQ 367
Cdd:PRK11448  211 SQErKQKRKEITDQAAKRLELSEEETRI 238

ATP-synt_Fo_b

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...

276-394

1.74e-05

Pssm-ID: 349951 [Multi-domain] Cd Length: 132 Bit Score: 45.12 E-value: 1.74e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 276 AERQQKEREELEwQQEIARQEAERQrkeeemrrQQEYAQQMAEmqrAQKEMEWQREIARQKAemdEKEKQRQVEIARQMA 355
Cdd:cd06503   29 DEREEKIAESLE-EAEKAKEEAEEL--------LAEYEEKLAE---ARAEAQEIIEEARKEA---EKIKEEILAEAKEEA 93

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 597837628 356 ERQRQEEellrQQEValqEAERQKKERERQKEIARQVVE 394
Cdd:cd06503   94 ERILEQA----KAEI---EQEKEKALAELRKEVADLAVE 125

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

266-463

2.09e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 48.23 E-value: 2.09e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 266 QRQQEIARQVAERQQKEREELEWQQEIAR----QEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDE 341
Cdd:COG4717  299 SLGKEAEELQALPALEELEEEELEELLAAlglpPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAE 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 342 KeKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERErqkEIARQVVERKKQEEVRRIEKARKksEMEKKERERQ 421
Cdd:COG4717  379 A-GVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELE---ELLEALDEEELEEELEELEEELE--ELEEELEELR 452

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 597837628 422 QEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIAR 463
Cdd:COG4717  453 EELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAA 494

Borrelia_P83

pfam05262

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

259-411

2.36e-05

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

Pssm-ID: 114011 [Multi-domain] Cd Length: 489 Bit Score: 48.08 E-value: 2.36e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQE------------------YAQQMAEMQ 320
Cdd:pfam05262 205 ERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAknlpkpadtsspkedkqvAENQKREIE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  321 RAQKEmewqreiARQKAEMDEKEKQRQVEIARQMAERQRQEEEllrqqevalQEAERQKKERERQKEIARQVVERKKQEE 400
Cdd:pfam05262 285 KAQIE-------IKKNDEEALKAKDHKAFDLKQESKASEKEAE---------DKELEAQKKREPVAEDLQKTKPQVEAQP 348

                         170
                  ....*....|.
gi 597837628  401 VRRIEKARKKS 411
Cdd:pfam05262 349 TSLNEDAIDSS 359

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

252-518

2.40e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 48.39 E-value: 2.40e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQRQQEIARQVAERQQKErEELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQRE 331
Cdd:COG1196  503 YEGFLEGVKAALLLAGLRGLAGAVAVLIGVE-AAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDK 581

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 332 IARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKS 411
Cdd:COG1196  582 IRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGS 661

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 412 EMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERL 491
Cdd:COG1196  662 LTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741

                        250       260
                 ....*....|....*....|....*..
gi 597837628 492 RKEEEQRIEAQRKAEEERRIEEQLAAR 518
Cdd:COG1196  742 LEEEELLEEEALEELPEPPDLEELERE 768

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

298-524

2.52e-05

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 48.04 E-value: 2.52e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   298 ERQRKEEEMRRQQEYaqqMAEMQRAQKEME----------WQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEEL--- 364
Cdd:pfam02463  154 RRLEIEEEAAGSRLK---RKKKEALKKLIEetenlaeliiDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLyld 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   365 ---LRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRI--EKARKKSEMEKK-----ERERQQEIARQHAERQRK 434
Cdd:pfam02463  231 ylkLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKEnkEEEKEKKLQEEElkllaKEEEELKSELLKLERRKV 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   435 EEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRK------RKIEEERLRKEEEQRIEAQRKAEEE 508
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEeleklqEKLEQLEEELLAKKKLESERLSSAA 390

                          250
                   ....*....|....*.
gi 597837628   509 RRIEEQLAAREVENQS 524
Cdd:pfam02463  391 KLKEEELELKSEEEKE 406

Caldesmon

Caldesmon;

220-521

2.57e-05

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 47.94 E-value: 2.57e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  220 EEQVGEERRRGGVEDhehpagsFRKQGPSGnfEEGSSNAEMEQLERQRQQEIARQVAERQQKEREE----LEWQQEiaRQ 295
Cdd:pfam02029   4 EEEAARERRRRAREE-------RRRQKEEE--EPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEeeafLDRTAK--RE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  296 EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqREIARQKAEMDEKEKQRQVEIARQMAE----RQRQEEELLRQQEVA 371
Cdd:pfam02029  73 ERRQKRLQEALERQKEFDPTIADEKESVAERK--ENNEEEENSSWEKEEKRDSRLGRYKEEeteiREKEYQENKWSTEVR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  372 lQEAERQKKERERQKEIARQVVERKKQEEVR--RIEKARKKSEMEKKERERQQEIARQHAE------------------- 430
Cdd:pfam02029 151 -QAEEEGEEEEDKSEEAEEVPTENFAKEEVKdeKIKKEKKVKYESKVFLDQKRGHPEVKSQngeeevtklkvttkrrqgg 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  431 ---RQRKEEEARRQEEARLFAERQKK---ERERQE-EIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQR 503
Cdd:pfam02029 230 lsqSQEREEEAEVFLEAEQKLEELRRrrqEKESEEfEKLRQKQQEAELELEELKKKREERRKLLEEEEQRRKQEEAERKL 309

                         330
                  ....*....|....*....
gi 597837628  504 KAEEE-RRIEEQLAAREVE 521
Cdd:pfam02029 310 REEEEkRRMKEEIERRRAE 328

AtpF

COG0711

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...

266-357

2.59e-05

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase

Pssm-ID: 440475 [Multi-domain] Cd Length: 152 Bit Score: 45.16 E-value: 2.59e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 266 QRQQEIARQV--AERQQKEREEL--EWQQEI--ARQEAERQRKE--EEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKA 337
Cdd:COG0711   31 ERQEKIADGLaeAERAKEEAEAAlaEYEEKLaeARAEAAEIIAEarKEAEAIAEEAKAEAEAEAERIIAQAEAEIEQERA 110

                         90       100
                 ....*....|....*....|
gi 597837628 338 EMDEKEKQRQVEIARQMAER 357
Cdd:COG0711  111 KALAELRAEVADLAVAIAEK 130

fliH

PRK06669

flagellar assembly protein H; Validated

252-389

2.61e-05

flagellar assembly protein H; Validated

Pssm-ID: 235850 [Multi-domain] Cd Length: 281 Bit Score: 46.93 E-value: 2.61e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAE-----MQRAQKEM 326
Cdd:PRK06669  56 EAKEIIEEAEEDAFEIVEAAEEEAKEELLKKTDEASSIIEKLQMQIEREQEEWEEELERLIEEAKAEgyeegYEKGREEG 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628 327 EwqreiarqkAEMDEKEKQRQVEIARQMAERQRQ----EEELLrqqEVALQEAERQKKER-ERQKEIA 389
Cdd:PRK06669 136 L---------EEVRELIEQLNKIIEKLIKKREEIlessEEEIV---ELALDIAKKVIKEIsENSKEIA 191

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

251-431

2.68e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.84 E-value: 2.68e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 251 FEEGSSNAEMEQLERQRQQEIARQVAERQQKEREEL--------EWQQ---EIARQEAERQRKEEEMRRQQEYAQQMAEM 319
Cdd:COG4717  304 AEELQALPALEELEEEELEELLAALGLPPDLSPEELlelldrieELQEllrEAEELEEELQLEELEQEIAALLAEAGVED 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 320 --------QRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQ 391
Cdd:COG4717  384 eeelraalEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELE 463

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 597837628 392 VVERKKQEEVRRIEKARKKSEMEKKERERQ-QEIARQHAER 431
Cdd:COG4717  464 QLEEDGELAELLQELEELKAELRELAEEWAaLKLALELLEE 504

PTZ00491

major vault protein; Provisional

266-432

2.77e-05

major vault protein; Provisional

Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 48.09 E-value: 2.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 266 QRQQEIARQVAERQ-QKEREELEWQQEIARQEAERQRKEeemrrqqeYAQQMAEMQRAQKEMEwQREIARQKAEMDEKEK 344
Cdd:PTZ00491 662 KSQEAAARHQAELLeQEARGRLERQKMHDKAKAEEQRTK--------LLELQAESAAVESSGQ-SRAEALAEAEARLIEA 732

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 345 QRQVEIARQMAERQRQEEEllrqqevALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEI 424
Cdd:PTZ00491 733 EAEVEQAELRAKALRIEAE-------AELEKLRKRQELELEYEQAQNELEIAKAKELADIEATKFERIVEALGRETLIAI 805


                 ....*...
gi 597837628 425 ARQHAERQ 432
Cdd:PTZ00491 806 ARAGPELQ 813

RIB43A

pfam05914

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...

258-365

3.10e-05

Pssm-ID: 461780 [Multi-domain] Cd Length: 372 Bit Score: 47.20 E-value: 3.10e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQ-----EI-----------ARQVAERQ---------------QKEREELEWQQEIARQEAERQRkEEEM 306
Cdd:pfam05914 219 AERRRLEKRQEQednlaEIynhltsdllteNPEVAQSSlgphrvipdrwkgmsPEQLKEIRKEQEQQREEKERRR-EEEK 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  307 RRQQEYAQQMAEMQRAQkeMEWQREIARQKAEMdekeKQRQVEIARQMAERQRQEEELL 365
Cdd:pfam05914 298 QRDAEWDRQRLELARAA--LLLEREQQRLRREL----RRQLDEENLQLAQEQKARQEYL 350

HCR

pfam07111

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...

259-401

3.24e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.

Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 47.82 E-value: 3.24e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQKEREELE---WQQEIARQEAERQRKE-----EEMRRQQEYAQQMAEMQRAQKEMEWQR 330
Cdd:pfam07111 513 EQGEAERQQLSEVAQQLEQELQRAQESLAsvgQQLEVARQGQQESTEEaaslrQELTQQQEIYGQALQEKVAEVETRLRE 592

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628  331 EIARQKAEMDE--KEKQRQVEIARQMAERQRQEEEllRQQEVALQEAERQKKERERqkeIARQVVERKKQEEV 401
Cdd:pfam07111 593 QLSDTKRRLNEarREQAKAVVSLRQIQHRATQEKE--RNQELRRLQDEARKEEGQR---LARRVQELERDKNL 660

growth_prot_Scy

NF041483

polarized growth protein Scy;

264-547

4.06e-05

polarized growth protein Scy;

Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 47.51 E-value: 4.06e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKErEELEWqqeiARQEAERQRKE-----EEMRRQQEYA----QQMAEMQRAQKEMEWQREIAR 334
Cdd:NF041483  505 ERVRTEAIERATTLRRQAE-ETLER----TRAEAERLRAEaeeqaEEVRAAAERAarelREETERAIAARQAEAAEELTR 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  335 QKAEMDEK--EKQRQVEIARQMAERQRQE--EELLRQQEVA------LQEAERQKKERERQKEIARQVVERKKQEEVRRI 404
Cdd:NF041483  580 LHTEAEERltAAEEALADARAEAERIRREaaEETERLRTEAaerirtLQAQAEQEAERLRTEAAADASAARAEGENVAVR 659

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  405 EKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERqeeiaRQMEEEEKRQREEAEKEEMRKR 484
Cdd:NF041483  660 LRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQEEAARRR-----REAEETLGSARAEADQERERAR 734

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628  485 KIEEERLRKEEEQRIEAQRKA-----EEERRIEEQLAAREVENQStVVNPAFGMH------IPGETQAGEHSTD 547
Cdd:NF041483  735 EQSEELLASARKRVEEAQAEAqrlveEADRRATELVSAAEQTAQQ-VRDSVAGLQeqaeeeIAGLRSAAEHAAE 807

MukB

COG3096

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

258-405

4.14e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 47.64 E-value: 4.14e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQ----------QEIARQVAERQQKEREELEwqqeiarQEAERQRKEEEMRRQQEyaqQMAEMQRAQKEME 327
Cdd:COG3096   522 AELEQRLRQQQnaerlleefcQRIGQQLDAAEELEELLAE-------LEAQLEELEEQAAEAVE---QRSELRQQLEQLR 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  328 WQREIARQKAEMDEKekqrqveiARQMAERQRQE--EELLRQQEValQEAERQKKERERQKEIARQVVERKKQEEVRRIE 405
Cdd:COG3096   592 ARIKELAARAPAWLA--------AQDALERLREQsgEALADSQEV--TAAMQQLLEREREATVERDELAARKQALESQIE 661

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

247-522

4.32e-05

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 47.37 E-value: 4.32e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   247 PSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQK-EREELEWQQEIARQEAERQRKEEEMRR-QQEYAQQMAEMQRAQK 324
Cdd:TIGR02169  651 KSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGlKRELSSLQSELRRIENRLDELSQELSDaSRKIGEIEKEIEQLEQ 730

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   325 EMEWQREIARQKAEmDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIarqvveRKKQEEVRRI 404
Cdd:TIGR02169  731 EEEKLKERLEELEE-DLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI------PEIQAELSKL 803

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   405 EKARkkSEMEKKERERQQEIARQHAERQrkeeearrqeearlFAERQKKERERQeeiarqmeeeekrqREE-AEKEEMRK 483
Cdd:TIGR02169  804 EEEV--SRIEARLREIEQKLNRLTLEKE--------------YLEKEIQELQEQ--------------RIDlKEQIKSIE 853

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 597837628   484 RKIEEERLRKEEEQRiEAQRKAEEERRIEEQLA--AREVEN 522
Cdd:TIGR02169  854 KEIENLNGKKEELEE-ELEELEAALRDLESRLGdlKKERDE 893

COG2433

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

271-416

4.40e-05

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 47.16 E-value: 4.40e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 271 IARQVAERQQKEREELEwqQEIARQEAERQRKEEEMRRQQEyaqqmaEMQRAQKE-MEWQREIARQKAEMDEKEKqrqvE 349
Cdd:COG2433  382 LEELIEKELPEEEPEAE--REKEHEERELTEEEEEIRRLEE------QVERLEAEvEELEAELEEKDERIERLER----E 449

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628 350 IARqmaERQRQEEELLRQQEValqeaerqkkeRERQKEIARqvVERKKQEEVRRIEKARKKSEMEKK 416
Cdd:COG2433  450 LSE---ARSEERREIRKDREI-----------SRLDREIER--LERELEEERERIEELKRKLERLKE 500

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

294-523

4.42e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 47.24 E-value: 4.42e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 294 RQEAERQRK--EEEMRR----QQEYAQQMAEMQRaqkemewQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQ 367
Cdd:COG1196  174 KEEAERKLEatEENLERlediLGELERQLEPLER-------QAEKAERYRELKEELKELEAELLLLKLRELEAELEELEA 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 368 QEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKsemekkERERQQEIARQHAERQRKeeearrqeearlf 447
Cdd:COG1196  247 ELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE------EYELLAELARLEQDIARL------------- 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628 448 AERQKKERERQEEIARQmeeeekrqreeaekeemrkrkieEERLRkEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:COG1196  308 EERRRELEERLEELEEE-----------------------LAELE-EELEELEEELEELEEELEEAEEELEEAEAE 359

HCR

pfam07111

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...

273-455

4.68e-05

Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 47.05 E-value: 4.68e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  273 RQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQ--EYAQQM-AEMQRAQKEM-----------EWQREIARQKAE 338
Cdd:pfam07111 484 EQLREERNRLDAELQLSAHLIQQEVGRAREQGEAERQQlsEVAQQLeQELQRAQESLasvgqqlevarQGQQESTEEAAS 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  339 MDEKEKQRQVEIARQMAERQRQEEELLRQQevaLQEAERQKKERERQKEIA----RQVvERKKQEEVRRIEKARKKSEME 414
Cdd:pfam07111 564 LRQELTQQQEIYGQALQEKVAEVETRLREQ---LSDTKRRLNEARREQAKAvvslRQI-QHRATQEKERNQELRRLQDEA 639

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 597837628  415 KKerERQQEIARQHAERQRKEEEARRQEEARLFAERQKKER 455
Cdd:pfam07111 640 RK--EEGQRLARRVQELERDKNLMLATLQQEGLLSRYKQQR 678

PRK03918

DNA double-strand break repair ATPase Rad50;

291-521

4.91e-05

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 47.37 E-value: 4.91e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 291 EIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEEL---LRQ 367
Cdd:PRK03918 177 RIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLegsKRK 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 368 QEVALQEAERQKKE-RERQKEIARQVVE----RKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERqrkeeearrqe 442
Cdd:PRK03918 257 LEEKIRELEERIEElKKEIEELEEKVKElkelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEING----------- 325

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628 443 earlfAERQKKERERQEEIARQMeeeekrqreEAEKEEMRKRKIEEERLRKEEEqriEAQRKAEEERRIEEQLAAREVE 521
Cdd:PRK03918 326 -----IEERIKELEEKEERLEEL---------KKKLKELEKRLEELEERHELYE---EAKAKKEELERLKKRLTGLTPE 387

Rabaptin

pfam03528

Rabaptin;

265-423

5.46e-05

Rabaptin;

Pssm-ID: 367545 [Multi-domain] Cd Length: 486 Bit Score: 46.64 E-value: 5.46e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  265 RQRQQEIARQVAE-RQQKEREELEWQQEIARQEAERQRKEEEMRRQQ--------EYAQQMAEMQRAQKEMEWQREIA-- 333
Cdd:pfam03528   7 QQRVAELEKENAEfYRLKQQLEAEFNQKRAKFKELYLAKEEDLKRQNavlqeaqvELDALQNQLALARAEMENIKAVAtv 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  334 ----RQKAeMDEKEKQRQVEIArqmaERQRQEEELLRQQEValQEAERQKKERERQKEIaRQVVERKKQEEVRRIEKARK 409
Cdd:pfam03528  87 sentKQEA-IDEVKSQWQEEVA----SLQAIMKETVREYEV--QFHRRLEQERAQWNQY-RESAEREIADLRRRLSEGQE 158

                         170
                  ....*....|....
gi 597837628  410 KSEMEKKERERQQE 423
Cdd:pfam03528 159 EENLEDEMKKAQED 172

OmpH

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

314-407

5.50e-05

Pssm-ID: 214922 [Multi-domain] Cd Length: 140 Bit Score: 43.73 E-value: 5.50e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   314 QQMAEMQRAQKEMEwqREIARQKAEMDEKEKQrqveiARQMAERQRQEEELLRQQEVALQEAERQKKERE--RQKEIARQ 391
Cdd:smart00935  11 QESPAGKAAQKQLE--KEFKKRQAELEKLEKE-----LQKLKEKLQKDAATLSEAAREKKEKELQKKVQEfqRKQQKLQQ 83

                           90
                   ....*....|....*.
gi 597837628   392 VVERKKQEEVRRIEKA 407
Cdd:smart00935  84 DLQKRQQEELQKILDK 99

ClpA

COG0542

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...

258-379

8.21e-05

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 46.61 E-value: 8.21e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQ-EIARQVAERQQKE--REELEwqqEIARQEAERQRKEEEMRRQQEyaqqmAEMQRAQKEMEWQREIAR 334
Cdd:COG0542  411 EELDELERRLEQlEIEKEALKKEQDEasFERLA---ELRDELAELEEELEALKARWE-----AEKELIEEIQELKEELEQ 482

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628 335 QKAEMDEKEKQRQvEIARQMAERQRQEEELLRQQEVA-------------LQEAERQK 379
Cdd:COG0542  483 RYGKIPELEKELA-ELEEELAELAPLLREEVTEEDIAevvsrwtgipvgkLLEGEREK 539

OmpH

pfam03938

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

293-397

8.59e-05

Pssm-ID: 461098 [Multi-domain] Cd Length: 140 Bit Score: 43.33 E-value: 8.59e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  293 ARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqreiaRQKAEMDEKEKQRQVEIARQMAERQRQEEEllRQQEVAL 372
Cdd:pfam03938  16 EGKAAQAQLEKKFKKRQAELEAKQKELQKLYEELQ------KDGALLEEEREEKEQELQKKEQELQQLQQK--AQQELQK 87

                          90       100
                  ....*....|....*....|....*
gi 597837628  373 QEAERQKKERERQKEIARQVVERKK 397
Cdd:pfam03938  88 KQQELLQPIQDKINKAIKEVAKEKG 112

PRK05035

electron transport complex protein RnfC; Provisional

265-486

8.86e-05

electron transport complex protein RnfC; Provisional

Pssm-ID: 235334 [Multi-domain] Cd Length: 695 Bit Score: 46.09 E-value: 8.86e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEReelewqqeiARQ--EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEK 342
Cdd:PRK05035 432 RQAKAEIRAIEQEKKKAEE---------AKArfEARQARLEREKAAREARHKKAAEARAAKDKDAVAAALARVKAKKAAA 502

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 343 EKQRQVEIARQ------MAERQ-RQEEELLRQQEVALQEAERQKKErERQKEIARqvVERKKQEevRRIEKARKKSEMEK 415
Cdd:PRK05035 503 TQPIVIKAGARpdnsavIAAREaRKAQARARQAEKQAAAAADPKKA-AVAAAIAR--AKAKKAA--QQAANAEAEEEVDP 577

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628 416 KERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKI 486
Cdd:PRK05035 578 KKAAVAAAIARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAV 648

GAF

COG2203

GAF domain [Signal transduction mechanisms];

269-527

9.74e-05

GAF domain [Signal transduction mechanisms];

Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 46.34 E-value: 9.74e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQVA---ERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQ 345
Cdd:COG2203  334 EALADQAAiaiERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLS 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 346 RQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIA 425
Cdd:COG2203  414 GLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALALLAALLLLLLL 493

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 426 RQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKA 505
Cdd:COG2203  494 LLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLTLVGVLLLLGLS 573

                        250       260
                 ....*....|....*....|..
gi 597837628 506 EEERRIEEQLAAREVENQSTVV 527
Cdd:COG2203  574 VLLIELALALILALALLELLLV 595

TPH

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

310-523

1.12e-04

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 45.29 E-value: 1.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  310 QEYAQQMAEMQRAQKEMEWQREIArQKAEMDEKEKQRQVEIARQM-AERQRQEEELLRQQEVALQEAERQKKERERQKEI 388
Cdd:pfam13868   6 DELRELNSKLLAAKCNKERDAQIA-EKKRIKAEEKEEERRLDEMMeEERERALEEEEEKEEERKEERKRYRQELEEQIEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  389 ARQvvERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEE 468
Cdd:pfam13868  85 REQ--KRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLK 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 597837628  469 EKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERriEEQLAAREVENQ 523
Cdd:pfam13868 163 EKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAER--DELRAKLYQEEQ 215

PTZ00266

NIMA-related protein kinase; Provisional

292-411

1.31e-04

NIMA-related protein kinase; Provisional

Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 45.88 E-value: 1.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  292 IARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKemewqreiaRQKAEMDEKEKQRQVEIARQMAERQRQEEELLrqqeva 371
Cdd:PTZ00266  430 VDKDHAERARIEKENAHRKALEMKILEKKRIER---------LEREERERLERERMERIERERLERERLERERL------ 494

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 597837628  372 lqeaERQKKERERQKEIARQVVERKKQEevrRIEKARKKS 411
Cdd:PTZ00266  495 ----ERDRLERDRLDRLERERVDRLERD---RLEKARRNS 527

tolA_full

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

340-518

1.53e-04

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 44.84 E-value: 1.53e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  340 DEKEKQRQV-EIARQMA-ERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVverKKQEEVRRIEKARKKSEMEKKE 417
Cdd:TIGR02794  44 DPGAVAQQAnRIQQQKKpAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRA---AAEKAAKQAEQAAKQAEEKQKQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  418 ----RERQQEIARQHAE---RQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEK--EEMRKRKIEE 488
Cdd:TIGR02794 121 aeeaKAKQAAEAKAKAEaeaERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKakAEEAKAKAEA 200

                         170       180       190
                  ....*....|....*....|....*....|
gi 597837628  489 ERLRKEEeqriEAQRKAEEERRIEEQLAAR 518
Cdd:TIGR02794 201 AKAKAAA----EAAAKAEAEAAAAAAAEAE 226

OmpH

pfam03938

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

257-334

1.54e-04

Pssm-ID: 461098 [Multi-domain] Cd Length: 140 Bit Score: 42.56 E-value: 1.54e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628  257 NAEMEQLERQRQQEIARQVAERQQKEREeleWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIAR 334
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEE---LQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQP 95

PTZ00266

NIMA-related protein kinase; Provisional

355-431

1.67e-04

NIMA-related protein kinase; Provisional

Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 45.50 E-value: 1.67e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  355 AERQRQEEELLRQQ--EVALQEAER-QKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAER 431
Cdd:PTZ00266  435 AERARIEKENAHRKalEMKILEKKRiERLEREERERLERERMERIERERLERERLERERLERDRLERDRLDRLERERVDR 514

Borrelia_P83

pfam05262

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

343-535

1.73e-04

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.

Pssm-ID: 114011 [Multi-domain] Cd Length: 489 Bit Score: 44.99 E-value: 1.73e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  343 EKQRQVEIARQMAE-RQRQEEELLRQQEVALQEAERQKKERERQK----------EIARQVVERKKQEEVRRIEKARKKS 411
Cdd:pfam05262 189 DNEKGVNFRRDMTDlKERESQEDAKRAQQLKEELDKKQIDADKAQqkadfaqdnaDKQRDEVRQKQQEAKNLPKPADTSS 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  412 EMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEkEEMRKRKieeerl 491
Cdd:pfam05262 269 PKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVA-EDLQKTK------ 341

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 597837628  492 rkeeeQRIEAQRKAEEERRIEEqlaarevenqstvVNPAFGMHI 535
Cdd:pfam05262 342 -----PQVEAQPTSLNEDAIDS-------------SNPVYGLKV 367

flagell_FliJ

TIGR02473

flagellar export protein FliJ; Members of this family are the FliJ protein found, in nearly ...

278-395

1.74e-04

flagellar export protein FliJ; Members of this family are the FliJ protein found, in nearly every case, in the midst of other flagellar biosynthesis genes in bacgterial genomes. Typically the fliJ gene is found adjacent to the gene for the flagellum-specific ATPase FliI. Sequence scoring in the gray zone between trusted and noise cutoffs include both probable FliJ proteins and components of bacterial type III secretion systems.

Pssm-ID: 131526 [Multi-domain] Cd Length: 141 Bit Score: 42.69 E-value: 1.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  278 RQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEK---------EKQRQV 348
Cdd:TIGR02473  12 EKEEEQAKLELAKAQAEFERLETQLQQLIKYREEYEQQALEKVGAGTSALELSNYQRFIRQLDQRiqqqqqelaLLQQEV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 597837628  349 EIARQMAERQRQEE---ELLRQQEVALQEAERQKKERERQKEIARQVVER 395
Cdd:TIGR02473  92 EAKRERLLEARRELkalEKLKEKKQKEYRAEEAKREQKEMDELATQRFRR 141

ATP-synt_Fo_b

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...

344-425

1.77e-04

Pssm-ID: 349951 [Multi-domain] Cd Length: 132 Bit Score: 42.42 E-value: 1.77e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 344 KQRQVEIARQM--AERQRQE-EELLRQQEVALQEAERQKKE-----RERQKEIARQVVERKKQEEVRRIEKARKKSEMEK 415
Cdd:cd06503   29 DEREEKIAESLeeAEKAKEEaEELLAEYEEKLAEARAEAQEiieeaRKEAEKIKEEILAEAKEEAERILEQAKAEIEQEK 108

                         90
                 ....*....|..
gi 597837628 416 KE--RERQQEIA 425
Cdd:cd06503  109 EKalAELRKEVA 120

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

334-523

1.83e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.14 E-value: 1.83e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 334 RQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVErKKQEEVRRIEKARKKSEM 413
Cdd:COG4717   52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELE-ELREELEKLEKLLQLLPL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 414 EKKERERQQEIAR-----QHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEE 488
Cdd:COG4717  131 YQELEALEAELAElperlEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAE 210

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 597837628 489 ERLRKEEEQRiEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:COG4717  211 LEEELEEAQE-ELEELEEELEQLENELEAAALEER 244

CCDC22

pfam05667

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...

241-425

1.84e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.

Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 45.02 E-value: 1.84e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  241 SFRKQGPSG-NFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEiARQEAERQRKEEEMRRQQEYAQQMAEM 319
Cdd:pfam05667 283 SFSGSSTTDtGLTKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQRE-EELEELQEQLEDLESSIQELEKEIKKL 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  320 QRAQKEMEwqREIARQKAEMDEKEKqrQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIAR----QVVER 395
Cdd:pfam05667 362 ESSIKQVE--EELEELKEQNEELEK--QYKVKKKTLDLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRvpliEEYRA 437

                         170       180       190
                  ....*....|....*....|....*....|
gi 597837628  396 KKQEEVRRIEKARKKSEMEKKERERQQEIA 425
Cdd:pfam05667 438 LKEAKSNKEDESQRKLEEIKELREKIKEVA 467

Cast

pfam10174

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

274-481

1.87e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 45.20 E-value: 1.87e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  274 QVAERQQKEREELEWQQeiaRQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEM---DEKEKQRQVEI 350
Cdd:pfam10174 450 RIIERLKEQREREDRER---LEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGlkkDSKLKSLEIAV 526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  351 ARQMAERQRQEEELLRQQEVALQE---AERQKKERERQKEIARQVVE-RKKQEEVRRIEKARKKSEMEKKERERQQEIAR 426
Cdd:pfam10174 527 EQKKEECSKLENQLKKAHNAEEAVrtnPEINDRIRLLEQEVARYKEEsGKAQAEVERLLGILREVENEKNDKDKKIAELE 606

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 597837628  427 QHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEM 481
Cdd:pfam10174 607 SLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELM 661

PRK03918

DNA double-strand break repair ATPase Rad50;

255-486

2.07e-04

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 45.05 E-value: 2.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 255 SSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEE------EMRRQQEYAQQ-MAEMQRAQKEME 327
Cdd:PRK03918 186 KRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeeieELEKELESLEGsKRKLEEKIRELE 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 328 WQREIARQKAEmDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAE-RQKKERERQKEIARQVVER-KKQEEVRRIE 405
Cdd:PRK03918 266 ERIEELKKEIE-ELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEkRLSRLEEEINGIEERIKELeEKEERLEELK 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 406 KARKKSE---MEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMR 482
Cdd:PRK03918 345 KKLKELEkrlEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKEL 424


                 ....
gi 597837628 483 KRKI 486
Cdd:PRK03918 425 KKAI 428

PLN02316

synthase/transferase

336-395

2.23e-04

synthase/transferase

Pssm-ID: 215180 [Multi-domain] Cd Length: 1036 Bit Score: 45.25 E-value: 2.23e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597837628  336 KAEMDE--------KEKQRQVE-IARQMAERQRQ-EEELLRQQEVALQEAERQ--KKERERQKEIARQVVER 395
Cdd:PLN02316  238 EGGMDEhsfedfllEEKRRELEkLAKEEAERERQaEEQRRREEEKAAMEADRAqaKAEVEKRREKLQNLLKK 309

Agg_substance

NF033875

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...

96-341

2.29e-04

Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 45.09 E-value: 2.29e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   96 PEPTTVRPYRPVFTTPNrKIVSSAATKSPKPPPTRTTATTLTTPPLKNRKVTEPIPVSEAQMTGMQPSTRGYTRGPQMHT 175
Cdd:NF033875   50 PGTTTVQPDNPDPQSGS-ETPKTAVSEEATVQKDTTSQPTKVEEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  176 tgVTAGTTSGEHMVNYKGITMSEDEFLKQLVRIVEAHQVAINKieeQVGEERRRGGVEDHEHPAGSFrkqGPSGNFEEGS 255
Cdd:NF033875  129 --VVSPETTNEPLGQPTEVAPAENEANKSTSIPKEFETPDVDK---AVDEAKKDPNITVVEKPAEDL---GNVSSKDLAA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  256 SNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEI-ARQEAERQRKEEEMRRQQEYAQQMAEMQRA-QKEMEWQREIA 333
Cdd:NF033875  201 KEKEVDQLQKEQAKKIAQQAAELKAKNEKIAKENAEIaAKNKAEKERYEKEVAEYNKHKNENGYVNEAiSKNLVFDQSVV 280


                  ....*...
gi 597837628  334 RQKAEMDE 341
Cdd:NF033875  281 TKDTKISS 288

MAT1

pfam06391

CDK-activating kinase assembly factor MAT1; MAT1 is an assembly/targeting factor for ...

257-370

2.31e-04

CDK-activating kinase assembly factor MAT1; MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH. The domain found to the N-terminal side of this domain is a C3HC4 RING finger.

Pssm-ID: 461894 [Multi-domain] Cd Length: 202 Bit Score: 43.38 E-value: 2.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  257 NAEMEQLERQRQQEIARQvAERQQKEREELEWQQEIARQEAERQRKEEemrrqqeyaQQMAEMQRAQKEMEwQREI--AR 334
Cdd:pfam06391  67 EKKIEQYEKENKDLILKN-KMKLSQEEEELEELLELEKREKEERRKEE---------KQEEEEEKEKKEKA-KQELidEL 135

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 597837628  335 QKAEMDEKE--KQRQVEIARQMAERQRQEEELLRQQEV 370
Cdd:pfam06391 136 MTSNKDAEEiiAQHKKTAKKRKSERRRKLEELNRVLEQ 173

ChtBD2

smart00494

Chitin-binding domain type 2;

657-696

2.65e-04

Chitin-binding domain type 2;

Pssm-ID: 214696 [Multi-domain] Cd Length: 49 Bit Score: 39.35 E-value: 2.65e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 597837628   657 PHPNDATRYLQCTPmigrrGRWTERMCPPNLVFIPSYGRC 696
Cdd:smart00494  12 PHPTDCSKYYQCSN-----GRPIVGSCPAGLVFNPATQTC 46

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

257-464

2.66e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 2.66e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 257 NAEMEQLERQ---RQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIA 333
Cdd:COG4372  107 QEEAEELQEEleeLQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 334 RQkaemdEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEM 413
Cdd:COG4372  187 EL-----LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIE 261

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 597837628 414 EKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQ 464
Cdd:COG4372  262 ELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGA 312

CCDC47

pfam07946

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...

357-422

2.68e-04

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.

Pssm-ID: 462322 Cd Length: 323 Bit Score: 44.10 E-value: 2.68e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  357 RQRQEEELLRQQEVALQEAERQKKErerqkeiarqvvERKKQEEVRRIEK----ARKKseMEKKERERQQ 422
Cdd:pfam07946 266 REEEIEKIKKAAEEERAEEAQEKKE------------EAKKKEREEKLAKlspeEQRK--YEEKERKKEQ 321

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

257-366

2.74e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 44.76 E-value: 2.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 257 NAEMEQLE--RQRQQEIARQVAERQQKEREELEWQQEIARQEAE-RQRKEEEMRR-QQEYAQQMAEMQRAQKEME-WQRE 331
Cdd:COG4717  142 AELPERLEelEERLEELRELEEELEELEAELAELQEELEELLEQlSLATEEELQDlAEELEELQQRLAELEEELEeAQEE 221

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 597837628 332 IARQKAEMDEKEKQRQVEiarQMAERQRQEEELLR 366
Cdd:COG4717  222 LEELEEELEQLENELEAA---ALEERLKEARLLLL 253

DDRGK

pfam09756

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...

333-417

2.94e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.

Pssm-ID: 370664 [Multi-domain] Cd Length: 188 Bit Score: 42.72 E-value: 2.94e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  333 ARQKAEMDEKEKQRQ----VEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQvvERKKQEEVRRIekar 408
Cdd:pfam09756   5 AKKRAKLELKEAKRQqreaEEEEREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQ--ERKEQEEYEKL---- 78


                  ....*....
gi 597837628  409 kKSEMEKKE 417
Cdd:pfam09756  79 -KSQFVVEE 86

sbcc

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

245-521

3.16e-04

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 44.57 E-value: 3.16e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   245 QGPSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAE------RQRKEEEMRRQQEYAQQMAE 318
Cdd:TIGR00618  151 QGEFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQlltlctPCMPDTYHERKQVLEKELKH 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   319 MQRAQKEMEWQREIARQKAEMDEKEKQRQveiarQMAERQRQEEELLRQQEVALqeaERQKKERERQKEIARQVVERKKQ 398
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQ-----QLLKQLRARIEELRAQEAVL---EETQERINRARKAAPLAAHIKAV 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   399 EEVRriekarkksemekkererqQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEK 478
Cdd:TIGR00618  303 TQIE-------------------QQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEV 363

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 597837628   479 EEMRKRKIEEERLRKEEEQRIEAQRKAEEERrieEQLAAREVE 521
Cdd:TIGR00618  364 ATSIREISCQQHTLTQHIHTLQQQKTTLTQK---LQSLCKELD 403

fliH

PRK06669

flagellar assembly protein H; Validated

262-419

3.53e-04

flagellar assembly protein H; Validated

Pssm-ID: 235850 [Multi-domain] Cd Length: 281 Bit Score: 43.47 E-value: 3.53e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 262 QLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAeMQRAQKEMEWQREIARQKAEmde 341
Cdd:PRK06669  13 NKEKLKTHEIQKYRFKVLSIKEKERLREEEEEQVEQLREEANDEAKEIIEEAEEDA-FEIVEAAEEEAKEELLKKTD--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 342 kEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSE--MEKKERE 419
Cdd:PRK06669  89 -EASSIIEKLQMQIEREQEEWEEELERLIEEAKAEGYEEGYEKGREEGLEEVRELIEQLNKIIEKLIKKREeiLESSEEE 167

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

292-515

3.90e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 44.14 E-value: 3.90e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  292 IARQEAERQRKEEEMRRQQEyaqQMAEMQRAQKEMEWQREIARQKAEMDEKE---KQRQVEIARQMAERQRqeeelLRQQ 368
Cdd:COG4913   612 LAALEAELAELEEELAEAEE---RLEALEAELDALQERREALQRLAEYSWDEidvASAEREIAELEAELER-----LDAS 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  369 EVALQEAERQKKERERQKEIARQvverkkqeevrRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFA 448
Cdd:COG4913   684 SDDLAALEEQLEELEAELEELEE-----------ELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLE 752

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  449 ERqkKERERQEEIARQMEEEekrqreeaekeemrkrkieeerlrkeeeqrIEAQRKAEEER--RIEEQL 515
Cdd:COG4913   753 ER--FAAALGDAVERELREN------------------------------LEERIDALRARlnRAEEEL 789

PRK07735

NADH-quinone oxidoreductase subunit C;

266-418

3.99e-04

NADH-quinone oxidoreductase subunit C;

Pssm-ID: 236081 [Multi-domain] Cd Length: 430 Bit Score: 43.82 E-value: 3.99e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 266 QRQQEIARQvAERQQKEREELEWQQEIARQEAERQRKE------------EEMRRQQEYAQQMAEMQRAQKEMEWQR--- 330
Cdd:PRK07735   9 DLKKEAARR-AKEEARKRLVAKHGAEISKLEEENREKEkalpknddmtieEAKRRAAAAAKAKAAALAKQKREGTEEvte 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 331 -EIARQKAEMDEKEKQRQVEIARQ--MAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQvvERKKQEEVRRIEKA 407
Cdd:PRK07735  88 eEKAKAKAKAAAAAKAKAAALAKQkrEGTEEVTEEEKAAAKAKAAAAAKAKAAALAKQKREGTE--EVTEEEEETDKEKA 165

                        170
                 ....*....|.
gi 597837628 408 RKKSEMEKKER 418
Cdd:PRK07735 166 KAKAAAAAKAK 176

Pinin_SDK_memA

pfam04696

pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...

255-330

4.36e-04

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.

Pssm-ID: 461396 [Multi-domain] Cd Length: 130 Bit Score: 41.12 E-value: 4.36e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628  255 SSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEemrrQQEYAQQMAEMQRAQKEMEWQR 330
Cdd:pfam04696  22 KKEESKQKEKEERRAEIEKRLEEKAKQEKEELEERKREEREELFEERRAE----QIELRALEEKLELKELMETWHE 93

PRK07352

F0F1 ATP synthase subunit B; Validated

263-382

4.45e-04

F0F1 ATP synthase subunit B; Validated

Pssm-ID: 180941 [Multi-domain] Cd Length: 174 Bit Score: 41.86 E-value: 4.45e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 263 LERqRQQEIA---RQVAERQQKEREELEWQQE---IARQEAERQRKEeemrrqqeyAQQMAEMQRAQKEMEWQREIAR-- 334
Cdd:PRK07352  48 LEE-RREAILqalKEAEERLRQAAQALAEAQQklaQAQQEAERIRAD---------AKARAEAIRAEIEKQAIEDMARlk 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 597837628 335 QKAEMDEKekqrqveiarqmAERQRQEEELLRQ-QEVALQEAERQKKER 382
Cdd:PRK07352 118 QTAAADLS------------AEQERVIAQLRREaAELAIAKAESQLPGR 154

CAF-1_p150

pfam11600

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...

290-420

4.46e-04

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.

Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 41.98 E-value: 4.46e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  290 QEIARQEAERQRKEEEmrRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQE 369
Cdd:pfam11600   4 QKSVQSQEEKEKQRLE--KDKERLRRQLKLEAEKEEKERLKEEAKAEKERAKEEARRKKEEEKELKEKERREKKEKDEKE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 597837628  370 VALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERER 420
Cdd:pfam11600  82 KAEKLRLKEEKRKEKQEALEAKLEEKRKKEEEKRLKEEEKRIKAEKAEITR 132

COG1340

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

257-461

4.61e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 43.36 E-value: 4.61e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 257 NAEMEQLeRQRQQEIARQVAERQQKEREELEWQQEIARQEAERQ----RKEEEMRRQQEYAQQMAEMQRAQKEMEWQREI 332
Cdd:COG1340   84 NEKLNEL-REELDELRKELAELNKAGGSIDKLRKEIERLEWRQQtevlSPEEEKELVEKIKELEKELEKAKKALEKNEKL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 333 ARQKAEMDEKEKQRQvEIARQMAERQRQEEELLRQQEVALQEAERQKKERErqkEIARQVVErkKQEEVRRIEKarKKSE 412
Cdd:COG1340  163 KELRAELKELRKEAE-EIHKKIKELAEEAQELHEEMIELYKEADELRKEAD---ELHKEIVE--AQEKADELHE--EIIE 234

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 597837628 413 MEKKERERQQEIARQHAERQRKEEearrqeearlfAERQKKERERQEEI 461
Cdd:COG1340  235 LQKELRELRKELKKLRKKQRALKR-----------EKEKEELEEKAEEI 272

RIB43A

pfam05914

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...

263-460

4.74e-04

Pssm-ID: 461780 [Multi-domain] Cd Length: 372 Bit Score: 43.35 E-value: 4.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  263 LERQRQQEIARQ----------------VAERQQKEREElewqqeiaRQEAERQRKE---EEMRRQQEYAQQM-AEMQRA 322
Cdd:pfam05914   9 IERRRQREEERKsrifnarnrtigvdveALDKQVEEKKR--------QEAAEKAREEafaEEMVQNDKIALMLeKREEED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  323 QKEME------WQREiarQKAEM---------DEKEKQRQVEIARQ------------MAERQRQEEELLRQQEVALQEA 375
Cdd:pfam05914  81 RRRLNkelnefRQQH---QRPETrrefdlndpDALKKDLPARVSDDdprcgpssmqkfEGEDLNREERKKLQQEQMREWL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  376 ERQKKERERQKEIARQvveRKKQEEVRRIEKARKKSEMEKKERERQQEIAR--------QHAERqrkeeearrqeearlf 447
Cdd:pfam05914 158 EQQIEEKKQAEEEEKH---AELLYDQKRLERDRRALELAKLEEECRRAVNAatknfnqaLAAEQ---------------- 218

                         250
                  ....*....|...
gi 597837628  448 AERQKKERERQEE 460
Cdd:pfam05914 219 AERRRLEKRQEQE 231

Crescentin

pfam19220

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...

258-432

4.81e-04

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.

Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 43.52 E-value: 4.81e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEI--ARQVAERQQKEREELEwQQEIARQEAERQRK---------EEEMRRQQ----EYAQQMAEMQRA 322
Cdd:pfam19220 118 AQAEALERQLAAETeqNRALEEENKALREEAQ-AAEKALQRAEGELAtarerlallEQENRRLQalseEQAAELAELTRR 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  323 QKEMEWQREIARQKAEMDEkekqrqVEIARQMAERQRQEEELLrqQEVALQEAERQKKERERQKEIAR---------QVV 393
Cdd:pfam19220 197 LAELETQLDATRARLRALE------GQLAAEQAERERAEAQLE--EAVEAHRAERASLRMKLEALTARaaateqllaEAR 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 597837628  394 E--RKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam19220 269 NqlRDRDEAIRAAERRLKEASIERDTLERRLAGLEADLERR 309

AtpF

COG0711

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...

308-404

5.29e-04

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase

Pssm-ID: 440475 [Multi-domain] Cd Length: 152 Bit Score: 41.31 E-value: 5.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 308 RQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEeellrqqevALQEAErqkKERERQKE 387
Cdd:COG0711   32 RQEKIADGLAEAERAKEEAEAALAEYEEKLAEARAEAAEIIAEARKEAEAIAEE---------AKAEAE---AEAERIIA 99

                         90       100
                 ....*....|....*....|
gi 597837628 388 IARQVVERKKQ---EEVRRI 404
Cdd:COG0711  100 QAEAEIEQERAkalAELRAE 119

HlpA

COG2825

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...

257-332

5.35e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 442073 [Multi-domain] Cd Length: 171 Bit Score: 41.75 E-value: 5.35e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628 257 NAEMEQLERQRQQEIARQVAERQQKErEELEwQQEIARQEAERQRKEEE-MRRQQEYAQQMAEMQR--AQKEMEWQREI 332
Cdd:COG2825   45 QKKLEKEFKKRQAELQKLEKELQALQ-EKLQ-KEAATLSEEERQKKERElQKKQQELQRKQQEAQQdlQKRQQELLQPI 121

KASH_CCD

pfam14662

Coiled-coil region of CCDC155 or KASH; This coiled-coil region is found in the central part of ...

253-414

5.45e-04

Coiled-coil region of CCDC155 or KASH; This coiled-coil region is found in the central part of KASH or Klarsicht/ANC-1/Syne/homology proteins. KASH are a meiosis-specific proteins that localize at telomeres and interact with SUN1, thus being implicated in meiotic chromosome dynamics and homolog pairing.

Pssm-ID: 405365 [Multi-domain] Cd Length: 191 Bit Score: 42.09 E-value: 5.45e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  253 EGSSNAEMEQLERQRQQEIARQVAERQQKE-REELEWQQEIARQEAERQRKEEEMRRQQEYAQQmaemQRAQKEMEWQRE 331
Cdd:pfam14662  35 EETNAKLLEENLNLRKQAKSQQQAVQKEKLlEEELEDLKLIVNSLEEARRSLLAQNKQLEKENQ----SLLQEIESLQEE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  332 IARQKAEMDEKEKQRQvEIARQMAERQRQEEELlrqQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKS 411
Cdd:pfam14662 111 NKKNQAERDKLQKKKK-ELLKSKACLKEQLHSC---EDLACNRETILIEKTTQIEELKSTVEEYSSIEEELRAEKSRLES 186


                  ...
gi 597837628  412 EME 414
Cdd:pfam14662 187 QLP 189

EVC2_like

pfam12297

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...

261-421

5.96e-04

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.

Pssm-ID: 463525 [Multi-domain] Cd Length: 428 Bit Score: 43.15 E-value: 5.96e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQEIARQVAERQQKEREELEWQQEiaRQEAERQRKEEEMRR--QQEYAQ--QMAEMQRAQKEMEWQREIARQK 336
Cdd:pfam12297 209 GRLQEEYERKMAALAAECNLETREKMEAQHQ--REMAEKEEAEELLKHadEQEALEcsSLLDKLHKLEQEHLQRSLLLRQ 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  337 AEMDEKekqrqveIARQMAERQRQEeeLLRQQEVALQEAERQKkerERQKEIARQVVERKKQ-----EEVRRIEKARKKS 411
Cdd:pfam12297 287 EEDFAK-------AQRQLAVFQRVE--LHKIFFTQLKEATRKG---ELKPEAAKRLLQDYSKiqeqiEELMDFFQANQRY 354

                         170
                  ....*....|
gi 597837628  412 EMEKKERERQ 421
Cdd:pfam12297 355 HLSERFAQRE 364

PRK14474

F0F1 ATP synthase subunit B; Provisional

262-393

6.08e-04

F0F1 ATP synthase subunit B; Provisional

Pssm-ID: 184696 [Multi-domain] Cd Length: 250 Bit Score: 42.50 E-value: 6.08e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 262 QLERQRQQEIARQVAERQQkereelewQQEIARQEAERQRKEeemrrQQEYAQQMAEMqraqkemewqreIARQKAEMDE 341
Cdd:PRK14474  32 QVMKKRQQRIANRWQDAEQ--------RQQEAGQEAERYRQK-----QQSLEQQRASF------------MAQAQEAADE 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 597837628 342 kEKQRQVEIARQMAERQRQE--EELLRQQEVALQEAerQKKERERQKEIARQVV 393
Cdd:PRK14474  87 -QRQHLLNEAREDVATARDEwlEQLEREKQEFFKAL--QQQTGQQMVKIIRAAL 137

ATP-synt_B

pfam00430

ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is ...

308-395

6.24e-04

ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is thought to translocate protons through membrane (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits. This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in pfam00006

Pssm-ID: 425677 [Multi-domain] Cd Length: 132 Bit Score: 40.76 E-value: 6.24e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  308 RQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQE------EELLRQQEVALQEAERQKKE 381
Cdd:pfam00430  31 RRELIADEIAEAEERRKDAAAALAEAEQQLKEARAEAQEIIENAKKRAEKLKEEivaaaeAEAERIIEQAAAEIEQEKDR 110

                          90
                  ....*....|....*....
gi 597837628  382 -----RERQKEIARQVVER 395
Cdd:pfam00430 111 alaelRQQVVALAVQIAEK 129

PRK03918

DNA double-strand break repair ATPase Rad50;

198-521

6.76e-04

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 43.51 E-value: 6.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 198 EDEFLKQLVRIVEAHQVAINKIEEQVGEERRRGGVEDHEHPAGSFRKqgpsgnfEEGSSNAEMEQLErqrqqEIARQVAE 277
Cdd:PRK03918 199 EKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEK-------ELESLEGSKRKLE-----EKIRELEE 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 278 RQQKEREELEWQQEIARQEAERQRKEEEMRR-QQEYAQQMAEMQRAQKEME-WQREIARQKAEMDEKE-KQRQVEIARQM 354
Cdd:PRK03918 267 RIEELKKEIEELEEKVKELKELKEKAEEYIKlSEFYEEYLDELREIEKRLSrLEEEINGIEERIKELEeKEERLEELKKK 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 355 AERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKE-RERQQEIARQHAERQR 433
Cdd:PRK03918 347 LKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKiTARIGELKKEIKELKK 426

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 434 KEEEARRQEEARLFAERQKKERERQEEIARQMEE----EEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEER 509
Cdd:PRK03918 427 AIEELKKAKGKCPVCGRELTEEHRKELLEEYTAElkriEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLK 506

                        330
                 ....*....|..
gi 597837628 510 RIEEQLAAREVE 521
Cdd:PRK03918 507 ELEEKLKKYNLE 518

DivIVA

COG3599

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...

277-360

6.95e-04

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442818 [Multi-domain] Cd Length: 125 Bit Score: 40.22 E-value: 6.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 277 ERQQKEREELEWQQEIARQEAERQRK-EEEMRRQQEYAQQMAEMQR--AQKEMEWQREIARQKAE-MDEKEKQRQVEIAR 352
Cdd:COG3599   37 ERLIRENKELKEKLEELEEELEEYRElEETLQKTLVVAQETAEEVKenAEKEAELIIKEAELEAEkIIEEAQEKARKIVR 116


                 ....*...
gi 597837628 353 QMAERQRQ 360
Cdd:COG3599  117 EIEELKRQ 124

CALCOCO1

pfam07888

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

264-419

7.62e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.96 E-value: 7.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  264 ERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMdeke 343
Cdd:pfam07888  38 ECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEEL---- 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628  344 KQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVrriEKARKKSEMEKKERE 419
Cdd:pfam07888 114 SEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEA---ERKQLQAKLQQTEEE 186

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

197-523

7.82e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.39 E-value: 7.82e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 197 SEDEFLKQLVRIVEAHQVAINKIEEQVGEERRRGGvEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQVA 276
Cdd:COG1196  380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLE-RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 277 ERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEW--------QREIARQKAEMDEKEK---- 344
Cdd:COG1196  459 EALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVkaalllagLRGLAGAVAVLIGVEAayea 538

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 345 -------QRQVEIARQMAERQRQEEELLRQQE---VALQEAERQKKERERQKEIARQVVERK------------------ 396
Cdd:COG1196  539 aleaalaAALQNIVVEDDEVAAAAIEYLKAAKagrATFLPLDKIRARAALAAALARGAIGAAvdlvasdlreadaryyvl 618

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 397 -KQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREE 475
Cdd:COG1196  619 gDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEA 698

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 597837628 476 AEKEEMRKRKIeeerlrKEEEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:COG1196  699 LLAEEEEEREL------AEAEEERLEEELEEEALEEQLEAEREELLEE 740

Caldesmon

Caldesmon;

220-413

8.02e-04

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 42.93 E-value: 8.02e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  220 EEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQ----KEREELE-------- 287
Cdd:pfam02029 118 EEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEvkdeKIKKEKKvkyeskvf 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  288 WQQEIARQEAERQRKEEE----------MRRQQEYAQQMAEMQRAQKEMEWQRE-IARQKAEMDEKE----KQRQVEIAR 352
Cdd:pfam02029 198 LDQKRGHPEVKSQNGEEEvtklkvttkrRQGGLSQSQEREEEAEVFLEAEQKLEeLRRRRQEKESEEfeklRQKQQEAEL 277

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628  353 QMAERQRQEEELLRqqevALQEAERQKKERERQKEIARQVVERKKQEEV--RRIEKARKKSEM 413
Cdd:pfam02029 278 ELEELKKKREERRK----LLEEEEQRRKQEEAERKLREEEEKRRMKEEIerRRAEAAEKRQKL 336

Spb1_C

pfam07780

Spb1 C-terminal domain; This presumed domain is found at the C-terminus of a family of ...

382-426

8.21e-04

Spb1 C-terminal domain; This presumed domain is found at the C-terminus of a family of FtsJ-like methyltransferases. Members of this family are involved in 60S ribosomal biogenesis, for example Swiss:P25582.

Pssm-ID: 462264 Cd Length: 209 Bit Score: 41.83 E-value: 8.21e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628  382 RERQKEI-AR---QVVE---RKKQEEVRRIEKARKKSEM-----EKKERERQQEIAR 426
Cdd:pfam07780  97 KEKLRALnARpikKVAEakaRKKMRAAKRLEKAKKKAELinedeDMSEREKAKQIEK 153

Lipase_chap

pfam03280

Proteobacterial lipase chaperone protein;

263-383

8.40e-04

Proteobacterial lipase chaperone protein;

Pssm-ID: 427230 [Multi-domain] Cd Length: 185 Bit Score: 41.14 E-value: 8.40e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  263 LERQR-QQEIARQVAERQQKereeleWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQ---------RAQKEMEWQREI 332
Cdd:pfam03280  64 LERLAiAQDSALSAEEKQQR------LAALRAQLPEDLRAAREAQQRLQELAARTAQLQkagaspqqlRQARAQLVGPEA 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 597837628  333 ARQKAEMDEKEKQRQVEIARQMAERQRQEEEllrqqevALQEAERQKKERE 383
Cdd:pfam03280 138 AQRLAALDQQRAAWQQRLDDYLAERQQINAA-------GLSEQERQAAIAQ 181

PRK09039

peptidoglycan -binding protein;

258-381

8.71e-04

peptidoglycan -binding protein;

Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 42.65 E-value: 8.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIARQVAERQ------QKEREELE-WQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEM---- 326
Cdd:PRK09039  66 ADLLSLERQGNQDLQDSVANLRaslsaaEAERSRLQaLLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELlnqq 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628 327 --EWQREIARQKAEMDEKEKQRQveiarqmaERQRQEEELLRQQEVAL----QEAERQKKE 381
Cdd:PRK09039 146 iaALRRQLAALEAALDASEKRDR--------ESQAKIADLGRRLNVALaqrvQELNRYRSE 198

PRK10927

cell division protein FtsN;

261-398

8.87e-04

cell division protein FtsN;

Pssm-ID: 236797 [Multi-domain] Cd Length: 319 Bit Score: 42.36 E-value: 8.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 261 EQLERQRQQEIARQVAERQQKERE--ELEWQQEIARQeaeRQRKEEEMRRQQEYAQ-QMAEMQRAQKEMEWQReiarQKA 337
Cdd:PRK10927 112 EQLTPEQRQLLEQMQADMRQQPTQlvEVPWNEQTPEQ---RQQTLQRQRQAQQLAEqQRLAQQSRTTEQSWQQ----QTR 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628 338 EMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQ 398
Cdd:PRK10927 185 TSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVTRAADAPKPTAEKKDE 245

GAS

pfam13851

Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...

283-426

9.21e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.

Pssm-ID: 464001 [Multi-domain] Cd Length: 200 Bit Score: 41.43 E-value: 9.21e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  283 REELEWQQEIARQEAERQRKEEEMRR-----QQEYAQQMAEMQRAQKEmewqREIARQKAEMDEKEKQRQVEIARQMAER 357
Cdd:pfam13851  22 RNNLELIKSLKEEIAELKKKEERNEKlmseiQQENKRLTEPLQKAQEE----VEELRKQLENYEKDKQSLKNLKARLKVL 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597837628  358 QRQEEELLRQQEVALQEAERQKKER----ERQKEIARQVVERKKQEEV---RRIEKARKksEMEKKERERQQEIAR 426
Cdd:pfam13851  98 EKELKDLKWEHEVLEQRFEKVERERdelyDKFEAAIQDVQQKTGLKNLlleKKLQALGE--TLEKKEAQLNEVLAA 171

DUF724

pfam05266

Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...

283-343

9.53e-04

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.

Pssm-ID: 428400 [Multi-domain] Cd Length: 188 Bit Score: 41.11 E-value: 9.53e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628  283 REELEWQQEiARQEAERQRKEEEMRRqQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKE 343
Cdd:pfam05266 101 KDRQTKLLE-ELKKLEKKIAEEESEK-RKLEEEIDELEKKILELERQLALAKEKKEAADKE 159

PRK03963

V-type ATP synthase subunit E; Provisional

269-369

1.02e-03

V-type ATP synthase subunit E; Provisional

Pssm-ID: 167649 [Multi-domain] Cd Length: 198 Bit Score: 41.28 E-value: 1.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQvAERqqkereELEWQQEIARQEAERQrKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQV 348
Cdd:PRK03963   9 QEINRE-AEQ------KIEYILEEAQKEAEKI-KEEARKRAESKAEWILRKAKTQAELEKQRIIANAKLEVRRKRLAVQE 80

                         90       100
                 ....*....|....*....|.
gi 597837628 349 EIARQMAERQRQEEELLRQQE 369
Cdd:PRK03963  81 ELISEVLEAVRERLAELPEDE 101

PRK07735

NADH-quinone oxidoreductase subunit C;

323-518

1.04e-03

NADH-quinone oxidoreductase subunit C;

Pssm-ID: 236081 [Multi-domain] Cd Length: 430 Bit Score: 42.66 E-value: 1.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 323 QKEMEWQREIARQKAEMDEKEK---QRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQE 399
Cdd:PRK07735   4 EKDLEDLKKEAARRAKEEARKRlvaKHGAEISKLEEENREKEKALPKNDDMTIEEAKRRAAAAAKAKAAALAKQKREGTE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 400 EVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKE 479
Cdd:PRK07735  84 EVTEEEKAKAKAKAAAAAKAKAAALAKQKREGTEEVTEEEKAAAKAKAAAAAKAKAAALAKQKREGTEEVTEEEEETDKE 163

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 597837628 480 EMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAR 518
Cdd:PRK07735 164 KAKAKAAAAAKAKAAALAKQKAAEAGEGTEEVTEEEKAK 202

DUF4200

pfam13863

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ...

280-364

1.11e-03

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.

Pssm-ID: 464003 [Multi-domain] Cd Length: 119 Bit Score: 39.47 E-value: 1.11e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  280 QKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQ--------KEMEWQREIARQKAEMDEKEKQR----- 346
Cdd:pfam13863   3 EKKREMFLVQLALDAKREEIERLEELLKQREEELEKKEQELKEDlikfdkflKENDAKRRRALKKAEEETKLKKEkekei 82

                          90       100
                  ....*....|....*....|.
gi 597837628  347 ---QVEIARQMAERQRQEEEL 364
Cdd:pfam13863  83 kklTAQIEELKSEISKLEEKL 103

PRK12705

hypothetical protein; Provisional

258-398

1.12e-03

hypothetical protein; Provisional

Pssm-ID: 237178 [Multi-domain] Cd Length: 508 Bit Score: 42.39 E-value: 1.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAER-----QRKEEEMRRQQEYAQQMAEMQRAQKE--MEWQR 330
Cdd:PRK12705  33 KEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARRereelQREEERLVQKEEQLDARAEKLDNLENqlEEREK 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597837628 331 EIARQKAEMDEKEKQRQ---VEIARQMAERQRQeeELLRQQEvalQEAERQKKER-ERQKEIARQVVERKKQ 398
Cdd:PRK12705 113 ALSARELELEELEKQLDnelYRVAGLTPEQARK--LLLKLLD---AELEEEKAQRvKKIEEEADLEAERKAQ 179

YscO

pfam07321

Type III secretion protein YscO; This family contains the bacterial type III secretion protein ...

265-414

1.14e-03

Type III secretion protein YscO; This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis.

Pssm-ID: 399954 [Multi-domain] Cd Length: 148 Bit Score: 40.46 E-value: 1.14e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  265 RQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIarqkAEMDEKEK 344
Cdd:pfam07321   8 KHLREDRAEKAVKRQEQALAAARAAHQQAQASLQDYRAWRPQEEQRLYAEIQGKLVLLKELEKVKQQV----ALLRENEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  345 QRQVEIArQMAERQRQEEELLRQQEVALQEAERQKkerERQKEIARQVverkkQEEVRRIEKARKKSEME 414
Cdd:pfam07321  84 DLEKQVA-EARQQLEAEREALRQARQALAEARRAV---EKFAELVRLV-----QAEELRQQERQEEQELE 144

PRK12678

transcription termination factor Rho; Provisional

225-457

1.31e-03

transcription termination factor Rho; Provisional

Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 42.58 E-value: 1.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 225 EERRRGG-VEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKE 303
Cdd:PRK12678  56 KEARGGGaAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGE 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 304 EEMRRQQEYAQQMAEmqraqkemewqreiaRQKAEMDEKEKQRQVEIARQMAERQRQEEEllRQQEVALQEAERQKKERE 383
Cdd:PRK12678 136 AARRGAARKAGEGGE---------------QPATEARADAAERTEEEERDERRRRGDRED--RQAEAERGERGRREERGR 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597837628 384 RQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEarlFAERQKKERER 457
Cdd:PRK12678 199 DGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGR---GGRRGRRFRDR 269

PRK07735

NADH-quinone oxidoreductase subunit C;

215-391

1.34e-03

NADH-quinone oxidoreductase subunit C;

Pssm-ID: 236081 [Multi-domain] Cd Length: 430 Bit Score: 42.27 E-value: 1.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 215 AINKIEEQVGEERRRGGVEDHEHPAGSFRKQGPSGNfeEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIAR 294
Cdd:PRK07735  47 ALPKNDDMTIEEAKRRAAAAAKAKAAALAKQKREGT--EEVTEEEKAKAKAKAAAAAKAKAAALAKQKREGTEEVTEEEK 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 295 QEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQE 374
Cdd:PRK07735 125 AAAKAKAAAAAKAKAAALAKQKREGTEEVTEEEEETDKEKAKAKAAAAAKAKAAALAKQKAAEAGEGTEEVTEEEKAKAK 204

                        170
                 ....*....|....*..
gi 597837628 375 AERQKKERERQKEIARQ 391
Cdd:PRK07735 205 AKAAAAAKAKAAALAKQ 221

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

299-517

1.42e-03

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 42.35 E-value: 1.42e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   299 RQRKEEEMRRQQEYAQQMAEMQRAQKEMEwqreiaRQKaemdeKEKQRQVEIARQMAERQRQEEELlrQQEVALQEAERQ 378
Cdd:TIGR02168  171 KERRKETERKLERTRENLDRLEDILNELE------RQL-----KSLERQAEKAERYKELKAELREL--ELALLVLRLEEL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   379 KKERERQKEIARQVVER---------KKQEEVRRIEKArkKSEMEKKERERQ-------QEIAR--QHAERQRKEEEARR 440
Cdd:TIGR02168  238 REELEELQEELKEAEEEleeltaelqELEEKLEELRLE--VSELEEEIEELQkelyalaNEISRleQQKQILRERLANLE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   441 QEEARLFAERQKKERERQEEIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERR-----IEEQL 515
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRskvaqLELQI 395


                   ..
gi 597837628   516 AA 517
Cdd:TIGR02168  396 AS 397

MukB

COG3096

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

253-431

1.47e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 42.63 E-value: 1.47e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  253 EGSSNAEMEQLeRQRQQEIARQVAERQQKEREelewQQEIARQEAERQrkeEEMRRQQEYAQQMAE---MQRAQkEMEWQ 329
Cdd:COG3096   831 APDPEAELAAL-RQRRSELERELAQHRAQEQQ----LRQQLDQLKEQL---QLLNKLLPQANLLADetlADRLE-ELREE 901

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  330 REIARQ-KAEMDEKEKQ-RQVEIARQMAERQRQEEELLRQQevaLQEAERQKKERERQKEIARQVVERKK----QEEVRR 403
Cdd:COG3096   902 LDAAQEaQAFIQQHGKAlAQLEPLVAVLQSDPEQFEQLQAD---YLQAKEQQRRLKQQIFALSEVVQRRPhfsyEDAVGL 978

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 597837628  404 I-------EKARKKSEMEKKERERQQEIARQHAER 431
Cdd:COG3096   979 LgensdlnEKLRARLEQAEEARREAREQLRQAQAQ 1013

DUF4670

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

384-517

1.62e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 41.86 E-value: 1.62e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  384 RQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIAR-QHAERQRKEEEARRQEEARLFAERQKKERERQEEI- 461
Cdd:pfam15709 328 REQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERaEKMREELELEQQRRFEEIRLRKQRLEEERQRQEEEe 407

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  462 ARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEqriEAQRKAEEERR---IEEQLAA 517
Cdd:pfam15709 408 RKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQE---EAERAEAEKQRqkeLEMQLAE 463

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

258-522

1.75e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 1.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 258 AEMEQLERQRQQEIAR------QVAERQQKEREELEWQQEIARQEAERQRKEEEM---------RRQQEYAQQMAEMQRA 322
Cdd:COG4717  132 QELEALEAELAELPERleeleeRLEELRELEEELEELEAELAELQEELEELLEQLslateeelqDLAEELEELQQRLAEL 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 323 QKEME-WQREIARQKAEMDEKEKQRQVE----------------------------------------------IARQMA 355
Cdd:COG4717  212 EEELEeAQEELEELEEELEQLENELEAAaleerlkearlllliaaallallglggsllsliltiagvlflvlglLALLFL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 356 ERQRQEEELLRQQEVALQEAERQKKERERQKEIARQV-----VERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAE 430
Cdd:COG4717  292 LLAREKASLGKEAEELQALPALEELEEEELEELLAALglppdLSPEELLELLDRIEELQELLREAEELEEELQLEELEQE 371

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 431 RQRKEEEARRQEEARLFA-----ERQKKERERQEEIARQMEEE---EKRQREEAEKEEMRKRKIEEERLRKEEEQRIEA- 501
Cdd:COG4717  372 IAALLAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELlgeLEELLEALDEEELEEELEELEEELEELEEELEEl 451

                        330       340
                 ....*....|....*....|..
gi 597837628 502 -QRKAEEERRIEEQLAAREVEN 522
Cdd:COG4717  452 rEELAELEAELEQLEEDGELAE 473

Golgin_A5

pfam09787

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...

258-380

1.76e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.

Pssm-ID: 462900 [Multi-domain] Cd Length: 305 Bit Score: 41.28 E-value: 1.76e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEiARQVAERQQkereelEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQRAQKeMEWQREIARQKA 337
Cdd:pfam09787  75 TELQELEAQQQEE-AESSREQLQ------ELEEQLATERSARREAEAELERLQEELRYLEEELRRSK-ATLQSRIKDREA 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 597837628  338 EMdekEKQRQVEIARQMAERQRQE-EELLRQqevaLQEAERQKK 380
Cdd:pfam09787 147 EI---EKLRNQLTSKSQSSSSQSElENRLHQ----LTETLIQKQ 183

HlpA

COG2825

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...

269-397

1.78e-03

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 442073 [Multi-domain] Cd Length: 171 Bit Score: 40.20 E-value: 1.78e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQVAERQQkEREELEwqQEIARQEAERQRKEEEMRrqqeyaqqmAEMQRAQKEmewqreiarqKAEMDEKEKQ-RQ 347
Cdd:COG2825   32 QRILQESPEGKA-AQKKLE--KEFKKRQAELQKLEKELQ---------ALQEKLQKE----------AATLSEEERQkKE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 597837628 348 VEIARQMAERQRQEEEllRQQEVALQEAERQKKERERQKEIARQVVERKK 397
Cdd:COG2825   90 RELQKKQQELQRKQQE--AQQDLQKRQQELLQPILEKIQKAIKEVAKEEG 137

mukB

PRK04863

chromosome partition protein MukB;

259-419

1.78e-03

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 42.25 E-value: 1.78e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARQVAERQQK--------EREELEWQQEIARQEAERQRkEEEMRRQQEYAQQMAEMQRAQ-KEMEWQ 329
Cdd:PRK04863  936 QFEQLKQDYQQAQQTQRDAKQQAfaltevvqRRAHFSYEDAAEMLAKNSDL-NEKLRQRLEQAEQERTRAREQlRQAQAQ 1014

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  330 REIARQ-----KAEMDEKEKQRQvEIARQMAERQRQ----EEELLRQQEVALQEAERQKKERERQKEIARQVVERKKQEE 400
Cdd:PRK04863 1015 LAQYNQvlaslKSSYDAKRQMLQ-ELKQELQDLGVPadsgAEERARARRDELHARLSANRSRRNQLEKQLTFCEAEMDNL 1093

                         170
                  ....*....|....*....
gi 597837628  401 VRRIEKARKKSEMEKKERE 419
Cdd:PRK04863 1094 TKKLRKLERDYHEMREQVV 1112

Caldesmon

Caldesmon;

258-522

1.83e-03

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 41.78 E-value: 1.83e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  258 AEMEQLERQRQQEiARQVAERQQKEREELEWQQEiaRQEAERQRKEEEMRRQQEYAQQMAEMQRAQKEMEWQREIARQKA 337
Cdd:pfam02029   2 EDEEEAARERRRR-AREERRRQKEEEEPSGQVTE--SVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  338 EMDEKEKQRQ-----VEIARQMAERQRQEEELlrQQEVALQEAERQKkERERQKEIARQVVERKKQEEVRRIEKARKKSE 412
Cdd:pfam02029  79 LQEALERQKEfdptiADEKESVAERKENNEEE--ENSSWEKEEKRDS-RLGRYKEEETEIREKEYQENKWSTEVRQAEEE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  413 MEKKEreRQQEIARQHAERQRKEEEARRQEEAR---------LFAERQKKERERQEEIARQMEEEEKRQREEaekeeMRK 483
Cdd:pfam02029 156 GEEEE--DKSEEAEEVPTENFAKEEVKDEKIKKekkvkyeskVFLDQKRGHPEVKSQNGEEEVTKLKVTTKR-----RQG 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 597837628  484 RKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVEN 522
Cdd:pfam02029 229 GLSQSQEREEEAEVFLEAEQKLEELRRRRQEKESEEFEK 267

DUF4618

pfam15397

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...

261-361

1.89e-03

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.

Pssm-ID: 464704 [Multi-domain] Cd Length: 258 Bit Score: 41.09 E-value: 1.89e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  261 EQLERQRQQeiarqVAERQQKEREELE--WQQEIARQEAERQRKEEEM-----RRQQEYAQQmAEMQRAQKEMEWQREIA 333
Cdd:pfam15397 123 ANLVRQLQQ-----LKDSQQDELDELEemRRMVLESLSRKIQKKKEKIlsslaEKTLSPYQE-SLLQKTRDNQVMLKEIE 196

                          90       100       110
                  ....*....|....*....|....*....|...
gi 597837628  334 RQKAEMDEKEK-----QRQVEIARQMAERQRQE 361
Cdd:pfam15397 197 QFREFIDELEEeipklKAEVQQLQAQRQEPREV 229

secA

PRK12903

preprotein translocase subunit SecA; Reviewed

252-386

1.97e-03

preprotein translocase subunit SecA; Reviewed

Pssm-ID: 237258 [Multi-domain] Cd Length: 925 Bit Score: 41.96 E-value: 1.97e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 252 EEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQ--QEYAQQMAEMQRAQKEmewQ 329
Cdd:PRK12903 788 TEILSDGINNSDINDRPQELIDQIIESEEERLKALRIQREEMLMRPEELELINEEQKNlkQEIKLELSEIQEAEEE---I 864

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628 330 REIARQKAEMDEKEKQ----RQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQK 386
Cdd:PRK12903 865 QNINENKNEFVEFKNDpkklNKLIIAKDVLIKLVISSDEIKQDEKTTKKKKKDLEKTDEEA 925

PRK13428

F0F1 ATP synthase subunit delta; Provisional

306-396

2.06e-03

F0F1 ATP synthase subunit delta; Provisional

Pssm-ID: 184048 [Multi-domain] Cd Length: 445 Bit Score: 41.64 E-value: 2.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 306 MRRQQEYA-QQMAEMQRAQKEMEwQREIARQKAEMDEK-EKQRQVEIARQMAERQRQEeelLRQQevALQEAERQKKERE 383
Cdd:PRK13428  30 MAARQDTVrQQLAESATAADRLA-EADQAHTKAVEDAKaEAARVVEEAREDAERIAEQ---LRAQ--ADAEAERIKVQGA 103

                         90
                 ....*....|...
gi 597837628 384 RQKEIARQVVERK 396
Cdd:PRK13428 104 RQVQLLRAQLTRQ 116

ATP-synt_Fo_b

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...

366-431

2.19e-03

Pssm-ID: 349951 [Multi-domain] Cd Length: 132 Bit Score: 38.96 E-value: 2.19e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628 366 RQQEVA--LQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEmekKERERQQEIARQHAER 431
Cdd:cd06503   31 REEKIAesLEEAEKAKEEAEELLAEYEEKLAEARAEAQEIIEEARKEAE---KIKEEILAEAKEEAER 95

CCDC47

pfam07946

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...

270-347

2.22e-03

Pssm-ID: 462322 Cd Length: 323 Bit Score: 41.01 E-value: 2.22e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628  270 EIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEyaQQMAEMQRAQkemewQREIarqkaemDEKEKQRQ 347
Cdd:pfam07946 257 EALKKAKKTREEEIEKIKKAAEEERAEEAQEKKEEAKKKERE--EKLAKLSPEE-----QRKY-------EEKERKKE 320

FliJ

pfam02050

Flagellar FliJ protein;

313-427

2.33e-03

Flagellar FliJ protein;

Pssm-ID: 426581 [Multi-domain] Cd Length: 123 Bit Score: 38.80 E-value: 2.33e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  313 AQQMAEMQRAQKEMEwqREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQV 392
Cdd:pfam02050   4 ARELAEAQRELQQAE--EKLEELQQYRAEYQQQLSGAGQGISAAELRNYQAFISQLDEAIAQQQQELAQAEAQVEKAREE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 597837628  393 VeRKKQEEVRRIEK--ARKKSEMEKKERERQQ----EIARQ 427
Cdd:pfam02050  82 W-QEARQERKSLEKlrEREKKEERKEQNRREQkqldELAAR 121

PRK07353

F0F1 ATP synthase subunit B'; Validated

294-395

2.47e-03

F0F1 ATP synthase subunit B'; Validated

Pssm-ID: 235999 [Multi-domain] Cd Length: 140 Bit Score: 39.22 E-value: 2.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 294 RQEAeRQRKEEEMRRQQEYAQQMAEMQR------AQKEMEWQReIARQKAEMDEKEKQRQVEIARQMAERQRQEeellrq 367
Cdd:PRK07353  45 RAEA-KERLAEAEKLEAQYEQQLASARKqaqaviAEAEAEADK-LAAEALAEAQAEAQASKEKARREIEQQKQA------ 116

                         90       100
                 ....*....|....*....|....*...
gi 597837628 368 qevALQEAERQkkererQKEIARQVVER 395
Cdd:PRK07353 117 ---ALAQLEQQ------VDALSRQILEK 135

PKK

pfam12474

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...

259-386

2.47e-03

Pssm-ID: 463600 [Multi-domain] Cd Length: 139 Bit Score: 39.08 E-value: 2.47e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  259 EMEQLERQRQQEIARqvAERQQK-EREELEWQQEIA-RQEAERQRKEEEMRrqqeyaqqMAEMQRAQKEmewqrEIARQK 336
Cdd:pfam12474  15 ERQQLKKRYEKELEQ--LERQQKqQIEKLEQRQTQElRRLPKRIRAEQKKR--------LKMFRESLKQ-----EKKELK 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 597837628  337 AEMDEKEKQRQVEIARQMAERQRQEEellRQQEVALQEAERQKKERERQK 386
Cdd:pfam12474  80 QEVEKLPKFQRKEAKRQRKEELELEQ---KHEELEFLQAQSEALERELQQ 126

OmpH

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

269-374

2.47e-03

Pssm-ID: 214922 [Multi-domain] Cd Length: 140 Bit Score: 39.10 E-value: 2.47e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   269 QEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQqeyAQQMAEMQRAQKEmewqREIARQKAEMDEKEKQRQV 348
Cdd:smart00935  11 QESPAGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKLQKD---AATLSEAAREKKE----KELQKKVQEFQRKQQKLQQ 83

                           90       100
                   ....*....|....*....|....*...
gi 597837628   349 EIARQMAERQRQEEELLRQ--QEVALQE 374
Cdd:smart00935  84 DLQKRQQEELQKILDKINKaiKEVAKKK 111

HAUS5

pfam14817

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...

268-377

2.61e-03

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.

Pssm-ID: 464332 [Multi-domain] Cd Length: 643 Bit Score: 41.57 E-value: 2.61e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  268 QQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQeyaqqmAEMQRAQKEmewqREIARQKAEMDEKEKQRQ 347
Cdd:pfam14817  69 AESRQSAAARRLELQKEIERLRAEISRLDKQLEARELELSREE------AERERALDE----ISDSRHRQLLLEAYDQQC 138

                          90       100       110
                  ....*....|....*....|....*....|
gi 597837628  348 VEIARQMAERQRQEEELLRQQEVALQEAER 377
Cdd:pfam14817 139 EEARKILAEDHQRLQGQLQQLRDAARKAEK 168

Pinin_SDK_memA

pfam04696

pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...

373-423

2.65e-03

Pssm-ID: 461396 [Multi-domain] Cd Length: 130 Bit Score: 38.81 E-value: 2.65e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 597837628  373 QEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQE 423
Cdd:pfam04696  23 KEESKQKEKEERRAEIEKRLEEKAKQEKEELEERKREEREELFEERRAEQI 73

FliH

COG1317

Flagellar biosynthesis/type III secretory pathway protein FliH [Cell motility, Intracellular ...

284-380

2.86e-03

Flagellar biosynthesis/type III secretory pathway protein FliH [Cell motility, Intracellular trafficking, secretion, and vesicular transport];

Pssm-ID: 440928 [Multi-domain] Cd Length: 172 Bit Score: 39.52 E-value: 2.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 284 EELEWQQEIARQEAERQRKEEEMRRQQEYAQQmaEMQRAQKEME-WQREIARQKAEMDEKEKQRQVEIARQMAER----- 357
Cdd:COG1317    2 EELEALREEAREEGYAEGYEEGLEEGRAEAEA--EIAEALEQLQaLLEQLQAPLEELDEELEEELVELALAIARKvigre 79

                         90       100
                 ....*....|....*....|....
gi 597837628 358 -QRQEEELLRQQEVALQEAERQKK 380
Cdd:COG1317   80 lALDPEAILALVREALAALREAEE 103

SMC_N

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

345-529

2.94e-03

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 41.50 E-value: 2.94e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   345 QRQVEIARQMAERQRQEEE------LLRQQEVALQEAERQKKERERQKEIARQVVERKKQEEVRRiEKARKKSEMEKKER 418
Cdd:pfam02463  141 GGKIEIIAMMKPERRLEIEeeaagsRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQ-AKKALEYYQLKEKL 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   419 ERQQEIARQHAERQRKEEEARRQEEARLfAERQKKERERQEEIARQMEEEEKRQREeaeKEEMRKRKIEEERLRKEEEQR 498
Cdd:pfam02463  220 ELEEEYLLYLDYLKLNEERIDLLQELLR-DEQEEIESSKQEIEKEEEKLAQVLKEN---KEEEKEKKLQEEELKLLAKEE 295

                          170       180       190
                   ....*....|....*....|....*....|.
gi 597837628   499 IEAQRKAEEERRIEEQLAAREVENQSTVVNP 529
Cdd:pfam02463  296 EELKSELLKLERRKVDDEEKLKESEKEKKKA 326

PRK13709

conjugal transfer nickase/helicase TraI; Provisional

275-408

3.00e-03

conjugal transfer nickase/helicase TraI; Provisional

Pssm-ID: 237478 [Multi-domain] Cd Length: 1747 Bit Score: 41.32 E-value: 3.00e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  275 VAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEmqraqkemewqreiaRQKAEMDEKEKQRQVEIARQM 354
Cdd:PRK13709 1627 NSVQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEIVRKMAE---------------NKPDLPDGKTEQAVRDIAGQE 1691

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628  355 AERQRQEEELLRQQEVALQEaerQKKERERQKEIARQVVERKK-----QEEVRRIEKAR 408
Cdd:PRK13709 1692 RDRAAISEREAALPESVLRE---PQREREAVREVARENLLRERlqqmeRDMVRDLQKEK 1747

PRK09039

peptidoglycan -binding protein;

269-389

3.03e-03

peptidoglycan -binding protein;

Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 40.72 E-value: 3.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 269 QEIARQVAERQQKEREELEWQ-QEIARQEA-ERQRKEEemrRQQEYAQQMAEMQRAQKEME----WQREIARQKAEMDEK 342
Cdd:PRK09039  41 QFFLSREISGKDSALDRLNSQiAELADLLSlERQGNQD---LQDSVANLRASLSAAEAERSrlqaLLAELAGAGAAAEGR 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 343 --EKQRQVEIARQMAERQRQEEELLRQQ-----------EVALQEAErqKKERERQKEIA 389
Cdd:PRK09039 118 agELAQELDSEKQVSARALAQVELLNQQiaalrrqlaalEAALDASE--KRDRESQAKIA 175

PRK07353

F0F1 ATP synthase subunit B'; Validated

265-357

3.22e-03

F0F1 ATP synthase subunit B'; Validated

Pssm-ID: 235999 [Multi-domain] Cd Length: 140 Bit Score: 38.83 E-value: 3.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 265 RQRQQEIARQVAERQQKEREeLEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQR---AQKEmEWQREIARQKAEMDE 341
Cdd:PRK07353  42 RTNRAEAKERLAEAEKLEAQ-YEQQLASARKQAQAVIAEAEAEADKLAAEALAEAQAeaqASKE-KARREIEQQKQAALA 119

                         90
                 ....*....|....*.
gi 597837628 342 KEKQRQVEIARQMAER 357
Cdd:PRK07353 120 QLEQQVDALSRQILEK 135

OmpH

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...

257-332

3.29e-03

Pssm-ID: 214922 [Multi-domain] Cd Length: 140 Bit Score: 38.72 E-value: 3.29e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597837628   257 NAEMEQLERQRQQEIARQVAErQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAEMQR--AQKEMEWQREI 332
Cdd:smart00935  20 QKQLEKEFKKRQAELEKLEKE-LQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQdlQKRQQEELQKI 96

mukB

PRK04863

chromosome partition protein MukB;

262-422

3.36e-03

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.48 E-value: 3.36e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  262 QLERQRQQEIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQ--MAEMQRAQKEMEWQREIARQKAEM 339
Cdd:PRK04863  488 EVSRSEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEfcKRLGKNLDDEDELEQLQEELEARL 567

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  340 DEKEKQrqVEIARQMAERQRQEEELLRQQE----------VALQEAERQKKE--------RERQKEIARQVVERKKQEEV 401
Cdd:PRK04863  568 ESLSES--VSEARERRMALRQQLEQLQARIqrlaarapawLAAQDALARLREqsgeefedSQDVTEYMQQLLERERELTV 645

                         170       180
                  ....*....|....*....|.
gi 597837628  402 RRIEKARKKSEMEKKERERQQ 422
Cdd:PRK04863  646 ERDELAARKQALDEEIERLSQ 666

sbcc

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

200-523

3.61e-03

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 41.11 E-value: 3.61e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   200 EFLKQLVRIVEaHQVAINKIEEQVGE--------ERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEI 271
Cdd:TIGR00618  287 NRARKAAPLAA-HIKAVTQIEQQAQRihtelqskMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVAT 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   272 ARQVAERQQKEREE--LEWQQEI-ARQEAERQRKEEEMRRQQEYAQQMAEMQR----------AQKEMEWQREIARQKAE 338
Cdd:TIGR00618  366 SIREISCQQHTLTQhiHTLQQQKtTLTQKLQSLCKELDILQREQATIDTRTSAfrdlqgqlahAKKQQELQQRYAELCAA 445

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   339 MDEKEKQRQVE---IARQMAERQRQEEELLRQQEV-ALQEAERQKKERERQKEIARQVVERKKQEevRRIEKARKKSEME 414
Cdd:TIGR00618  446 AITCTAQCEKLekiHLQESAQSLKEREQQLQTKEQiHLQETRKKAVVLARLLELQEEPCPLCGSC--IHPNPARQDIDNP 523

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   415 KKERERQQEIARQHAERQRKEEEARRQEEARLfaeRQKKERERQEEIARQmEEEEKRQREEAEKEEMRKRKIEEERLRKE 494
Cdd:TIGR00618  524 GPLTRRMQRGEQTYAQLETSEEDVYHQLTSER---KQRASLKEQMQEIQQ-SFSILTQCDNRSKEDIPNLQNITVRLQDL 599

                          330       340
                   ....*....|....*....|....*....
gi 597837628   495 EEQRIEAQRKAEEERRIEEQLAAREVENQ 523
Cdd:TIGR00618  600 TEKLSEAEDMLACEQHALLRKLQPEQDLQ 628

ERM_helical

pfam20492

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...

258-318

3.88e-03

Pssm-ID: 466641 [Multi-domain] Cd Length: 120 Bit Score: 37.98 E-value: 3.88e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597837628  258 AEMEQLERQRqqeiARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQEYAQQMAE 318
Cdd:pfam20492  62 EEKERLEESA----EMEAEEKEQLEAELAEAQEEIARLEEEVERKEEEARRLQEELEEARE 118

Activator_LAG-3

pfam11498

Transcriptional activator LAG-3; The C.elegans Notch pathway, involved in the control of ...

296-432

4.04e-03

Transcriptional activator LAG-3; The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1. Its N-terminal region adopts an elongated kinked helix that is required for complex assembly.

Pssm-ID: 151935 [Multi-domain] Cd Length: 476 Bit Score: 40.72 E-value: 4.04e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  296 EAERQRKEEEMRRQQEYAQQMAEMQRAQKEMewqREIARQKAEMDEKEKQRQVEIARQMAERQRQEEE-----LLRQQEV 370
Cdd:pfam11498 302 EAGGDRMPQSAPPPAMNPQHIAQLAQQQNKM---RLLQQQEMEMQRIEQQRQQQIMHQHQQQQQQEHQqqqmlLQQQQQM 378

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628  371 -ALQEAERQKKERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam11498 379 hQLQQHHQMNGGGQFATQAHQHAAYLQQMQHMRLQEQIQHQQQQAQHHQQAQQQHQQPAQHGQ 441

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

294-528

4.37e-03

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 40.81 E-value: 4.37e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   294 RQEAERQ--RKEEEMRRQQEYAqqmAEMQRAQKEMEWQREIARQKAEMdeKEKQRQVEIARQMAERQRQEEELlRQQEVA 371
Cdd:TIGR02168  174 RKETERKleRTRENLDRLEDIL---NELERQLKSLERQAEKAERYKEL--KAELRELELALLVLRLEELREEL-EELQEE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   372 LQEAERQKKERERQKeiarqvveRKKQEEVRRIEKARkkSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQ 451
Cdd:TIGR02168  248 LKEAEEELEELTAEL--------QELEEKLEELRLEV--SELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQ 317

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 597837628   452 KKERERQEEIARQMeeeekrqreeaeKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEEQLAAREVENQSTVVN 528
Cdd:TIGR02168  318 LEELEAQLEELESK------------LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLE 382

flagell_FliJ

TIGR02473

flagellar export protein FliJ; Members of this family are the FliJ protein found, in nearly ...

299-464

4.47e-03

Pssm-ID: 131526 [Multi-domain] Cd Length: 141 Bit Score: 38.45 E-value: 4.47e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  299 RQRKEEEMRRQQEYAQQMAEMQRAQKEMEwQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQ 378
Cdd:TIGR02473   9 DLREKEEEQAKLELAKAQAEFERLETQLQ-QLIKYREEYEQQALEKVGAGTSALELSNYQRFIRQLDQRIQQQQQELALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  379 KKERERQKEIARQvverkKQEEVRRIEKARkksemEKKERERQqeiarqhaerqrkeeearrqeearlfAERQKKERERQ 458
Cdd:TIGR02473  88 QQEVEAKRERLLE-----ARRELKALEKLK-----EKKQKEYR--------------------------AEEAKREQKEM 131


                  ....*.
gi 597837628  459 EEIARQ 464
Cdd:TIGR02473 132 DELATQ 137

DUF1387

pfam07139

Protein of unknown function (DUF1387); This family represents a conserved region approximately ...

236-414

4.62e-03

Protein of unknown function (DUF1387); This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.

Pssm-ID: 462100 Cd Length: 311 Bit Score: 40.11 E-value: 4.62e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  236 EHPAGSFRKQGPSGNFEEGSSnAEMEQLERQRQQEIARQVAERQQKEREELewQQEIARQEAERQRKEEEM----RRQQe 311
Cdd:pfam07139 122 LSRNASKPKSRPSSNKSLLED-APLSSTDDKLGSSIEKKVGPNIEKSVKDL--QRCTVSLTRYRVVIKEEMdasiKKIK- 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  312 yaQQMAEMQRAQKEMEwqreiARQKAEMDeKEKQRQVEIarqMAERQRQEEELLRQQEVALQEAERQKKE-RERQKEIar 390
Cdd:pfam07139 198 --ATFAELQSCLMDRE-----VALLAEMD-KVKAEAMEI---LTARQKKAEELKRLTDLAVQMSEEQLVElRADIKHF-- 264

                         170       180
                  ....*....|....*....|....
gi 597837628  391 qVVERKKQEEVRRIekARKKSEME 414
Cdd:pfam07139 265 -VSERKYDEELGRA--ARFTCDLE 285

sbcc

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

233-513

4.82e-03

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 40.72 E-value: 4.82e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   233 EDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQ--EIARQVAERQQKEREELEWQQEIARQEAERQRKEEEMRRQQ 310
Cdd:TIGR00618  545 EDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRskEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPE 624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   311 EYAQQMAEMQRaQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAErqrQEEELLRQQEVALQEAERQKKERERQKEIAR 390
Cdd:TIGR00618  625 QDLQDVRLHLQ-QCSQELALKLTALHALQLTLTQERVREHALSIRV---LPKELLASRQLALQKMQSEKEQLTYWKEMLA 700

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   391 QVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEARRQEEARLFAERQKKERERQE----------- 459
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEvtaalqtgael 780

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628   460 -----EIARQMEEEEKRQREEAEKEEMRKRKIEEERLRKEEEQRIEAQRKAEEERRIEE 513
Cdd:TIGR00618  781 shlaaEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEE 839

PKK

pfam12474

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...

334-432

5.00e-03

Pssm-ID: 463600 [Multi-domain] Cd Length: 139 Bit Score: 38.31 E-value: 5.00e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  334 RQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVAL-QEAERQKKERERqkeiarqvvERKKQEEVRRIEKARKKSE 412
Cdd:pfam12474  11 RFEQERQQLKKRYEKELEQLERQQKQQIEKLEQRQTQELrRLPKRIRAEQKK---------RLKMFRESLKQEKKELKQE 81

                          90       100
                  ....*....|....*....|
gi 597837628  413 MEKKERERQQEIARQHAERQ 432
Cdd:pfam12474  82 VEKLPKFQRKEAKRQRKEEL 101

HflC

COG0330

Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational ...

268-355

5.18e-03

Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440099 [Multi-domain] Cd Length: 279 Bit Score: 39.82 E-value: 5.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 268 QQEIARQVAERQQKEREELEWQ----QEIARQEAERQRKEEEMRrqqeyAQQMAEMQRAQKEMEWQREIARQKAEMDEKE 343
Cdd:COG0330  170 QDAMEDRMKAEREREAAILEAEgyreAAIIRAEGEAQRAIIEAE-----AYREAQILRAEGEAEAFRIVAEAYSAAPFVL 244

                         90
                 ....*....|..
gi 597837628 344 KQRQVEIARQMA 355
Cdd:COG0330  245 FYRSLEALEEVL 256

PTZ00266

NIMA-related protein kinase; Provisional

374-464

5.62e-03

NIMA-related protein kinase; Provisional

Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 40.49 E-value: 5.62e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  374 EAERQKKERERQKEIARQVVERKKQEEVRRIEKAR-KKSEMEKKERERqqeIARQHAERQRkeeearrqeearlfAERQK 452
Cdd:PTZ00266  436 ERARIEKENAHRKALEMKILEKKRIERLEREERERlERERMERIERER---LERERLERER--------------LERDR 498

                          90
                  ....*....|..
gi 597837628  453 KERERQEEIARQ 464
Cdd:PTZ00266  499 LERDRLDRLERE 510

Caldesmon

Caldesmon;

215-435

5.69e-03

Caldesmon;

Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.24 E-value: 5.69e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  215 AINKIEEQVGEERRRGGVEDHEHPAGSFRKQGPSGNFEEGSSNAEMEQLERQRQQEIARQVAERQQKEREELEWQQEIAR 294
Cdd:pfam02029  92 TIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPT 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  295 Q-------EAERQRKEEEM------------RRQQEYAQQMAEMQRAQKEMEWQREIARQKAEMDEKEKQRQVEiARQMA 355
Cdd:pfam02029 172 EnfakeevKDEKIKKEKKVkyeskvfldqkrGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAEVFLE-AEQKL 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  356 ERQRQeeellRQQEVALQEAERQkkeRERQKEIARQVVERKKQEEVRRieKARkksemEKKERERQQEiarqHAERQRKE 435
Cdd:pfam02029 251 EELRR-----RRQEKESEEFEKL---RQKQQEAELELEELKKKREERR--KLL-----EEEEQRRKQE----EAERKLRE 311

MAT1

pfam06391

CDK-activating kinase assembly factor MAT1; MAT1 is an assembly/targeting factor for ...

336-423

5.80e-03

Pssm-ID: 461894 [Multi-domain] Cd Length: 202 Bit Score: 39.15 E-value: 5.80e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  336 KAEMDEKEKQRQVEIARQMAERQRQEEELLRQqevalQEAERQKKERERQKEIARQVVERKKQEEVRR------------ 403
Cdd:pfam06391  67 EKKIEQYEKENKDLILKNKMKLSQEEEELEEL-----LELEKREKEERRKEEKQEEEEEKEKKEKAKQelidelmtsnkd 141

                          90       100
                  ....*....|....*....|....
gi 597837628  404 ----IEKARKKSEMEKKERERQQE 423
Cdd:pfam06391 142 aeeiIAQHKKTAKKRKSERRRKLE 165

CAF-1_p150

pfam11600

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...

320-438

5.97e-03

Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 38.52 E-value: 5.97e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  320 QRAQKEMEWQREIARQKAEMDEKEKQRQVEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEiarqvVERKKQE 399
Cdd:pfam11600   1 RRSQKSVQSQEEKEKQRLEKDKERLRRQLKLEAEKEEKERLKEEAKAEKERAKEEARRKKEEEKELKE-----KERREKK 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 597837628  400 EVRRIEKARKKSEMEKKERERQQEIARQHAERQRKEEEA 438
Cdd:pfam11600  76 EKDEKEKAEKLRLKEEKRKEKQEALEAKLEEKRKKEEEK 114

NtpE

COG1390

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal ...

319-415

6.25e-03

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 is part of the Pathway/BioSystem: A/V-type ATP synthase

Pssm-ID: 441000 [Multi-domain] Cd Length: 196 Bit Score: 38.77 E-value: 6.25e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 319 MQRAQKEMEWQREIARQKAE--MDEKEKQRQvEIARQMAERQRQEEELLRQQEVALQEAERQKKERERQKEIARQVVERK 396
Cdd:COG1390   12 LEEAEAEAEEILEEAEEEAEkiLEEAEEEAE-EIKEEILEKAEREAEREKRRIISSAELEARKELLEAKEELIEEVFEEA 90

                         90
                 ....*....|....*....
gi 597837628 397 KQeevrRIEKARKKSEMEK 415
Cdd:COG1390   91 LE----KLKNLPKDPEYKE 105

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

252-463

6.29e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 40.54 E-value: 6.29e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   252 EEGSSNAEMEQLERQRQQEIARQVAERQQKER----------EELEWQQEI--------ARQEAERQ-----------RK 302
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELEKKHQqlceeknalqEQLQAETELcaeaeemrARLAARKQeleeilhelesRL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   303 EEEMRRQQEYAQQMAEMQRAQKEMEWQ---REIARQKAEM-----DEKEKQRQVEI-------ARQMAERQRQEEELLRQ 367
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQldeEEAARQKLQLekvttEAKIKKLEEDIllledqnSKLSKERKLLEERISEF 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628   368 QEVALQEAERQK---KERERQKEIARQVVERKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAErqrkeeearrqeEA 444
Cdd:pfam01576  165 TSNLAEEEEKAKslsKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQ------------IA 232

                          250
                   ....*....|....*....
gi 597837628   445 RLFAERQKKERERQEEIAR 463
Cdd:pfam01576  233 ELRAQLAKKEEELQAALAR 251

YqiK

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

390-519

6.31e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];

Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 39.86 E-value: 6.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628 390 RQVVERKKQEEVRRIEkARKKSEMEKKERERQQEIARQHAERQRKEEEArrqeearlfAERQKKERERQEEIARQmeeee 469
Cdd:COG2268  192 RKIAEIIRDARIAEAE-AERETEIAIAQANREAEEAELEQEREIETARI---------AEAEAELAKKKAEERRE----- 256

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 597837628 470 krqREE---------AEKEEMRKRKIEEERLRKEEEQRIEAQRKaEEERRIEEQLAARE 519
Cdd:COG2268  257 ---AETaraeaeaayEIAEANAEREVQRQLEIAEREREIELQEK-EAEREEAELEADVR 311

ARGLU

pfam15346

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...

295-432

6.53e-03

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.

Pssm-ID: 405931 [Multi-domain] Cd Length: 151 Bit Score: 38.11 E-value: 6.53e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  295 QEAERQRKEEEMRRQQEyaqqMAEMQRAQKEMEwqreiaRQKAEMdEKEKQRQVEIARQMAERQRqEEELLRQQEVAL-- 372
Cdd:pfam15346   1 KEAESKLLEEETARRVE----EAVAKRVEEELE------KRKDEI-EAEVERRVEEARKIMEKQV-LEELEREREAELee 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597837628  373 ----QEAERQKKE------RERQKEIARQvveRKKQEEVRRIEKARKKSEMEKKERERQQEIARQHAERQ 432
Cdd:pfam15346  69 errkEEEERKKREelerilEENNRKIEEA---QRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQQ 135

SPFH_like_u3

cd03406

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...

257-327

6.64e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.

Pssm-ID: 259804 [Multi-domain] Cd Length: 293 Bit Score: 39.59 E-value: 6.64e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597837628 257 NAEMEQLERQRQQEIARQVAerqqkereELEWQQEIARQEAERQRK--EEEMRRQQEYAQQMAEMQRAQKEME 327
Cdd:cd03406  191 EAETERKRAVIEAEKDAEVA--------KIQMQQKIMEKEAEKKISeiEDEMHLAREKARADAEYYRALREAE 255

OmpH