NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|586232463|gb|EWQ37414|]
View 

phage DNA packaging protein [Staphylococcus aureus M1168]

Protein Classification

head-tail connector protein( domain architecture ID 10169104)

phage gp6-like head-tail connector protein is critical in the assembly of the connector, a specialized phage structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage

Gene Ontology:  GO:0016032
PubMed:  19895817

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 2-90 7.30e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


:

Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.48  E-value: 7.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586232463  2 SLEEIKLWLRIDYNFENDLIEGLIQSAKSELL----LSGVPDYDKDDLEYPLFCTAIKYIIARDYESRGYSNDQSRSKVf 77
Cdd:cd08054   1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIEnytgRDLDEQTADAEEVPALIKLAVLLLVAHLYENREAVTDVTASEL- 79

                        90
                ....*....|...
gi 586232463 78 nEKGLQKMILKLK 90
Cdd:cd08054  80 -PFGVESLLAPYR 91
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 2-90 7.30e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.48  E-value: 7.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586232463  2 SLEEIKLWLRIDYNFENDLIEGLIQSAKSELL----LSGVPDYDKDDLEYPLFCTAIKYIIARDYESRGYSNDQSRSKVf 77
Cdd:cd08054   1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIEnytgRDLDEQTADAEEVPALIKLAVLLLVAHLYENREAVTDVTASEL- 79

                        90
                ....*....|...
gi 586232463 78 nEKGLQKMILKLK 90
Cdd:cd08054  80 -PFGVESLLAPYR 91
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 2-76 7.94e-11

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 53.15  E-value: 7.94e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 586232463   2 SLEEIKLWLRIDYNFENDLIEGLIQSAKSELLLSGVPDYDKDDLEYPLFCTAIKYIIARDYESRGYSNDQSRSKV 76
Cdd:TIGR01560  1 TLDEVKLSLRIDHDDDDELIKLMIAAAQDYIQSAIGTGVKDSFDSKPLFKLACIKLVAHYYENRGLYADRALVNV 75
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 1-76 6.18e-10

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 50.87  E-value: 6.18e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 586232463   1 MSLEEIKLWLRIDYNFENDLIEGLIQSAKSELLL-SGVPDYDKDDLEYPL-FCTAIKYIIARDYESRGYSNDQSRSKV 76
Cdd:pfam05135  2 ITLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENyLGRSLGDPDAISLPAdLKYAVLELAVARYNNRGNEGMSSYSEE 79
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 2-90 7.30e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 63.48  E-value: 7.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586232463  2 SLEEIKLWLRIDYNFENDLIEGLIQSAKSELL----LSGVPDYDKDDLEYPLFCTAIKYIIARDYESRGYSNDQSRSKVf 77
Cdd:cd08054   1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIEnytgRDLDEQTADAEEVPALIKLAVLLLVAHLYENREAVTDVTASEL- 79

                        90
                ....*....|...
gi 586232463 78 nEKGLQKMILKLK 90
Cdd:cd08054  80 -PFGVESLLAPYR 91
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 2-76 7.94e-11

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 53.15  E-value: 7.94e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 586232463   2 SLEEIKLWLRIDYNFENDLIEGLIQSAKSELLLSGVPDYDKDDLEYPLFCTAIKYIIARDYESRGYSNDQSRSKV 76
Cdd:TIGR01560  1 TLDEVKLSLRIDHDDDDELIKLMIAAAQDYIQSAIGTGVKDSFDSKPLFKLACIKLVAHYYENRGLYADRALVNV 75
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 1-76 6.18e-10

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 50.87  E-value: 6.18e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 586232463   1 MSLEEIKLWLRIDYNFENDLIEGLIQSAKSELLL-SGVPDYDKDDLEYPL-FCTAIKYIIARDYESRGYSNDQSRSKV 76
Cdd:pfam05135  2 ITLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENyLGRSLGDPDAISLPAdLKYAVLELAVARYNNRGNEGMSSYSEE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH