|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
6-874 |
1.85e-110 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 360.51 E-value: 1.85e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 6 KKRGKLTIYLGYSPGVGKTYEMLSNGIDQYQEGADIKIGYIEPHQRPETNALVQQLPEISTSSRKFGSHTFHYIDVSKII 85
Cdd:PRK10490 20 PHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPPKRIHHRGRHISEFDLDAAL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 86 EANPDVVLIDELAHTNISKERHLKRYKDIEEILSHGIDVWTTLNIQHIESLSGQIALMTGIQVTERVPDQFITSADAFEV 165
Cdd:PRK10490 100 ARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPFFDAADEVVL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 166 VDISPNMLIQRLKAGKVYKKERLETAFSNFFTYENLTELRELTLRTVAD--------IMSQKGQQyKTKHTdiTPHIAVA 237
Cdd:PRK10490 180 VDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADrvddqmraWRDHQGEE-KVWHT--RDAILLC 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 238 ISGSIYNERVIREARRAAYKEHAKFTAVYIdvfETPSESR---KQDHYVHKNLMLAKALGAEIKVLYAQDIAKALTDWCD 314
Cdd:PRK10490 257 IGHNTGSEKLVRTAARLAARLGSVWHAVYV---ETPRLHRlpeKKRRAILSALRLAQELGAETATLSDPAEEKAVLRYAR 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 315 LAFVTKLVLGQSEQPRWKDyfKQSLIEQINHVPHHFKLEIVPIHYIHSDKPTNTPKQAQKSSRLTVEIMKMLVIQTICVL 394
Cdd:PRK10490 334 EHNLGKIIIGRRASRRWWR--RESFADRLARLGPDLDLVIVALDEPPARAIAKAPDSRPFKEKWRVQIQGCLVAIALCAL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 395 LGI----WVYNLDKsessAIILLMFFIGIIVLSI----WTQSyligfFASILNVFVFNYFFTVPRFTLEMYRFEYPITFA 466
Cdd:PRK10490 412 ITLiamqWLPAFDA----ANLVMLYLLGVVVVALfygrWPSV-----VATVINVASFDLFFVAPRGTLAVSDVQYLLTFA 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 467 TSIFASIftsaILKNlkhqhsLTERQLYRTNIMLQFNQSIKESYSIERLLNIAgdqihqLLNQDVtvflIQSKKVAASNS 546
Cdd:PRK10490 483 VMLTVGL----VIGN------LTAGVRYQARVARYREQRTRHLYEMSKALAVG------LSPEDI----AATSEHFLAST 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 547 FGNRS---ISSSDK-----THDAETLS-------WVIENESRAGKLTDTFPGSKFLCIPIGT-NPVKGVISIRFTD---- 606
Cdd:PRK10490 543 FQARSqllLPDDNGklqplTHDQGMTPwddaiarWSFDKGQPAGAGTDTLPGVPYQILPLKSaQKTYGLLAVEPGNlrql 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 607 -----ETYIDTYdnSILdsmlndITLAIENVDLLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGnldmlkyhne 681
Cdd:PRK10490 623 mipeqQRLLETF--TLL------IANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFG---------- 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 682 hlndqqQAELLT---ASYGEA----------QYLHT--LVTNILSLTKLESSDIQIQR---TPYLVEELLEEFEEGLIRR 743
Cdd:PRK10490 685 ------QAEILTldlASEGSPharqaseirqQVLNTtrLVNNLLDMARIQSGGFNLRKewlTLEEVVGSALQMLEPGLSG 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 744 HqanHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYY 823
Cdd:PRK10490 759 H---PINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFA 835
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 586186223 824 SGDnfKDNKKDSLGLGLYLVQLILKQHNSELeYQPNTPQ-GSIFYFYLTVNP 874
Cdd:PRK10490 836 RGN--KESAIPGVGLGLAICRAIVEVHGGTI-WAENRPEgGACFRVTLPLET 884
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
7-214 |
1.06e-103 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 319.74 E-value: 1.06e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 7 KRGKLTIYLGYSPGVGKTYEMLSNGIDQYQEGADIKIGYIEPHQRPETNALVQQLPEISTSSRKFGSHTFHYIDVSKIIE 86
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 87 ANPDVVLIDELAHTNISKERHLKRYKDIEEILSHGIDVWTTLNIQHIESLSGQIALMTGIQVTERVPDQFITSADAFEVV 166
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 586186223 167 DISPNMLIQRLKAGKVYKKERLETAFSNFFTYENLTELRELTLRTVAD 214
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVAD 208
|
|
| KdpD_non_kinase |
NF038185 |
KdpD-like non-kinase potassium sensor; Members of this family contain the N-terminal sensor ... |
7-355 |
7.90e-82 |
|
KdpD-like non-kinase potassium sensor; Members of this family contain the N-terminal sensor region, but lack the C-terminal histidine kinase region, of the sensor histidine kinase KdpD found broadly in species such as Escherichia coli, Mycobacterium tuberculosis, Clostridium acetobutylicum, and Staphylococcus aureus. Members are found in Bacillus anthracis and related species.
Pssm-ID: 468400 [Multi-domain] Cd Length: 373 Bit Score: 268.16 E-value: 7.90e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 7 KRGKLTIYLGYSPGVGKTYEMLSNGIDQYQEGADIKIGYIEPHQRPETNALVQQLPEISTSSRKFGSHTFHYIDVSKIIE 86
Cdd:NF038185 17 KRGKLKIYIGAAPGVGKTYKMLQDAHELKKEGIDVVIGLVETHGRKETEEQIGDLEIIPLKEIPYKGKEFQELDVEAIIK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 87 ANPDVVLIDELAHTNISKERHLKRYKDIEEILSHGIDVWTTLNIQHIESLSGQIALMTGIQVTERVPDQFITSADAFEVV 166
Cdd:NF038185 97 RNPQVVIIDELAHTNAPGSKNKKRYQDVQELLDAGISVMSAVNIQHLESVRDIVNQITGVKVRERIPDFILQKADEIQLV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 167 DISPNMLIQRLKAGKVYKKERLETAFSNFFTYENLTELRELTLRTVADIMSQKGQQYKTKHTD----ITPHIAVAISGSI 242
Cdd:NF038185 177 DVTPETLRKRLREGKIYSPEKIEQSLNNFFTLGNLSALRELTLREVADDVDDRLEKYRNKGVVgpigINEKILVCVQYRP 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 243 YNERVIREARRAAYKEHAKFTAVYIDVFETPSESRKQDHYvHKNLMLAKALGAEIKVLYAQD--IAKALTDWCDLAFVTK 320
Cdd:NF038185 257 NAEKLIRRGWRMADRLKADLYILHVYNEEELLSEKNKKKI-KEWQMLANQFNASFIVEEAKSrkPAQVIIEVAKQNNITQ 335
|
330 340 350
....*....|....*....|....*....|....*
gi 586186223 321 LVLGQSEQPRWKDYFKQSLIEQINHVPHHFKLEIV 355
Cdd:NF038185 336 ILLGQSARTRWEEIRKGSIVNAIMRQTKNIDIHIV 370
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
635-870 |
4.98e-59 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 201.67 E-value: 4.98e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 635 LKQTRQSILKAEReaTRSNFLHSISHDIRTPLTSIMGNLDMLKyHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTK 714
Cdd:COG2205 2 LEEALEELEELER--LKSEFLANVSHELRTPLTSILGAAELLL-DEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 715 LESSDIQIQRTPYLVEELLEEFEEGLIRRHQANH--VIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHV 792
Cdd:COG2205 79 LESGKLSLELEPVDLAELLEEAVEELRPLAEEKGirLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 586186223 793 QHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNfkDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:COG2205 159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
233-356 |
3.04e-48 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 167.04 E-value: 3.04e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 233 HIAVAISGSIYNERVIREARRAAYKEHAKFTAVYIDVFETPSESRKQDHYVHKNLMLAKALGAEIKVLYAQDIAKALTDW 312
Cdd:cd01987 1 RILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEF 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 586186223 313 CDLAFVTKLVLGQSEQPRWKDYFKQSLIEQINHVPHHFKLEIVP 356
Cdd:cd01987 81 ARERNVTQIVLGQSRRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
600-870 |
7.13e-46 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 167.78 E-value: 7.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 600 ISIRFTDETYIDTYDNSILDSMLNDITLAIENVDLLKQTRQSILKAER-EATRSNFLHSISHDIRTPLTSIMGNLDMLky 678
Cdd:COG0642 58 LLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEaNEAKSRFLANVSHELRTPLTAIRGYLELL-- 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 679 hnEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHV--IIENEDD 756
Cdd:COG0642 136 --LEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIelELDLPDD 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 757 ASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNfkDNKKDSL 836
Cdd:COG0642 214 LPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGT 291
|
250 260 270
....*....|....*....|....*....|....
gi 586186223 837 GLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:COG0642 292 GLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
488-870 |
2.20e-45 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 168.19 E-value: 2.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 488 LTERQLYRTNIMLQFNQSIKESYSIERLLNIAGDQIHQLLNQDVTVFLIQSKKVAASNSFGNRSISSSDKTHDAETLSWV 567
Cdd:COG5002 8 LLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 568 IENESRAGKLTDTFPGSKFLCIPIGTNPVKGVISIRFTDETYIDTYDNSILDSMLNDITLAIEnvdllkqTRQSILKAER 647
Cdd:COG5002 88 LLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAA-------VERDITELER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 648 -EATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEHLNDQQQaELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTP 726
Cdd:COG5002 161 lEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERR-EYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 727 YLVEELLEEFEEGLIRRHQANHV--IIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMI 804
Cdd:COG5002 240 VDLAELLEEVVEELRPLAEEKGIelELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586186223 805 DCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:COG5002 320 DTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
642-870 |
9.60e-29 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 120.07 E-value: 9.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 642 ILKAEREATRSNFLHSISHDIRTPLTSIMGNLDML--KYHNEHLNDQQQAELLTAS-YGEAQYLHTLVTNILSLTKLesS 718
Cdd:COG5000 192 LLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLrrKLADKLEEDREDLERALDTiIRQVDRLKRIVDEFLDFARL--P 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 719 DIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNK 798
Cdd:COG5000 270 EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 586186223 799 IKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:COG5000 350 VRIEVSDNGPGIPEEVLERIFEPFFT------TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
762-870 |
2.37e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 110.05 E-value: 2.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 762 IDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNfKDNKKDSLGLGLY 841
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100
....*....|....*....|....*....
gi 586186223 842 LVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
599-870 |
8.61e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 116.05 E-value: 8.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 599 VISIRFTDETYIDTYDNSILDSMLNDITLAIENVDLLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLK- 677
Cdd:COG4191 90 LEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRr 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 678 YHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQ-------IQRTpylveelleefeeGLIRRHQANH-- 748
Cdd:COG4191 170 RLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREpvdlnelIDEA-------------LELLRPRLKArg 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 749 --VIIENEDDASLINIDSKLILQVLFNLIDNALkHA---ESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYY 823
Cdd:COG4191 237 ieVELDLPPDLPPVLGDPGQLEQVLLNLLINAI-DAmeeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF 315
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 586186223 824 SgdnfkdNKKDS--LGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:COG4191 316 T------TKPVGkgTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
643-878 |
5.44e-27 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 113.40 E-value: 5.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 643 LKAEREATRSNFLHS-------ISHDIRTPLTSIMGNLDMLKyhnEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKL 715
Cdd:COG3852 120 KRLERELRRAEKLAAvgelaagLAHEIRNPLTGIRGAAQLLE---RELPDDELREYTQLIIEEADRLNNLVDRLLSFSRP 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 716 ESSDIQ-------IQRTpylveelleefeEGLIRRHQANHVIIENEDDASL--INIDSKLILQVLFNLIDNALKHAESHS 786
Cdd:COG3852 197 RPPEREpvnlhevLERV------------LELLRAEAPKNIRIVRDYDPSLpeVLGDPDQLIQVLLNLVRNAAEAMPEGG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 787 EIKL----------HVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGdnfkdnKKDSLGLGLYLVQLILKQHNSELEY 856
Cdd:COG3852 265 TITIrtrverqvtlGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTT------KEKGTGLGLAIVQKIVEQHGGTIEV 338
|
250 260
....*....|....*....|..
gi 586186223 857 QPNTPQGSIFYFYLTVNPIEME 878
Cdd:COG3852 339 ESEPGKGTTFRIYLPLEQAEEE 360
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
769-870 |
4.57e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 103.07 E-value: 4.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 769 QVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDnfKDNKKDSLGLGLYLVQLILK 848
Cdd:cd00075 3 QVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGD--KSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 586186223 849 QHNSELEYQPNTPQGSIFYFYL 870
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
598-870 |
1.24e-23 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 105.64 E-value: 1.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 598 GVISIRFTDETYIDTYDNSILDSMLNDITLAIENVDLLKQTRQSILKAEREATRSN-----FLHSISHDIRTPLTSIMGN 672
Cdd:COG4251 224 GLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNeeleqFAYVASHDLREPLRKISGF 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 673 LDMLK-YHNEHLNDQQQAELLTASYGeAQYLHTLVTNILSLTKLESSDIQIQRTPylVEELLEEFEEGLIRRHQANHVII 751
Cdd:COG4251 304 SQLLEeDYGDKLDEEGREYLERIRDA-AERMQALIDDLLAYSRVGRQELEFEPVD--LNELLEEVLEDLEPRIEERGAEI 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 752 ENEDDASlINIDSKLILQVLFNLIDNALKHA--ESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNfk 829
Cdd:COG4251 381 EVGPLPT-VRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS-- 457
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 586186223 830 DNKKDSLGLGLYLVQLILKQHNSE--LEYQPNtpQGSIFYFYL 870
Cdd:COG4251 458 RDEYEGTGIGLAIVKKIVERHGGRiwVESEPG--EGATFYFTL 498
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
763-870 |
2.61e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 92.43 E-value: 2.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHEtNKIKFEMIDCGKGIPEEERQLIFNPYYSGDnfkDNKKDSLGLGLYL 842
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100
....*....|....*....|....*...
gi 586186223 843 VQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
382-492 |
2.85e-21 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 89.44 E-value: 2.85e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 382 IMKMLVIQTICVLLGIWVYNLDkseSSAIILLMFFIGIIVLSIWTqSYLIGFFASILNVFVFNYFFTVPRFTLEMYRFEY 461
Cdd:pfam13493 1 YLLAVLILALATLLALLLRPLL---PLANIALLFLLAVLLVALRG-GRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGY 76
|
90 100 110
....*....|....*....|....*....|.
gi 586186223 462 PITFATSIFASIFTSAILKNLKHQHSLTERQ 492
Cdd:pfam13493 77 LLTLVVFLLVALLTSTLTARLRRQARQARRR 107
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
638-873 |
3.86e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 88.30 E-value: 3.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 638 TRQSILKA----EREATRSNFLHSISHDIRTPLTSIMGnldMLKYHNEHL----NDQQQAELLTasyGEAQYLHTLVTNI 709
Cdd:PRK10364 220 SRQLLQDEmkrkEKLVALGHLAAGVAHEIRNPLSSIKG---LAKYFAERApaggEAHQLAQVMA---KEADRLNRVVSEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 710 LSLTKleSSDIQIQRTpylvEELLEEFEEGLIRRHQANHVIIENE----DDASLINIDSKLILQVLFNLIDNALKHAESH 785
Cdd:PRK10364 294 LELVK--PTHLALQAV----DLNDLINHSLQLVSQDANSREIQLRftanDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 786 SEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSI 865
Cdd:PRK10364 368 GVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFT------TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441
|
....*...
gi 586186223 866 FYFYLTVN 873
Cdd:PRK10364 442 FTLWLPVN 449
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
643-872 |
8.87e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 86.16 E-value: 8.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 643 LKAEREA--TRSNFLHSI----SHDIRTPLTSIMGNLDMLKYHNEHLNDQQQAELLTASYGEA----QYLHTLVTNILSL 712
Cdd:PRK09303 137 LRQENETllEQLKFKDRVlamlAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQLQDQArrqlEEIERLITDLLEV 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 713 TKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENE--DDASLINIDSKLILQVLFNLIDNALKHAESHSEIKL 790
Cdd:PRK09303 217 GRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDipSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 791 HVQHETN-KIKFEMIDCGKGIPEEERQLIFnpyysGDNFK---DNKKDSLGLGLYLVQLILKQHNSEL--EYQPNtpQGS 864
Cdd:PRK09303 297 SMLHRTTqKVQVSICDTGPGIPEEEQERIF-----EDRVRlprDEGTEGYGIGLSVCRRIVRVHYGQIwvDSEPG--QGS 369
|
....*...
gi 586186223 865 IFYFYLTV 872
Cdd:PRK09303 370 CFHFTLPV 377
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
624-882 |
1.99e-17 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 87.87 E-value: 1.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 624 DITLAIENVDLLKQTRQSILKAEreATRSNFLHSISHDIRTPLTSIMGNLDMLKyhNEHLNDQQQAELLTASYGEAQYLH 703
Cdd:PRK09959 687 DITETRDLIHALEVERNKAINAT--VAKSQFLATMSHEIRTPISSIMGFLELLS--GSGLSKEQRVEAISLAYATGQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 704 TLVTNILSLTKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENED---DASLINIDSKLILQVLFNLIDNALK 780
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALK 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 781 HAeSHSEIKL-----HVQHETNKIKFEMIDCGKGIPEEERQLIFNPYysGDNFKDNKKDSLGLGLYLVQLILKQHNSELE 855
Cdd:PRK09959 843 FT-TEGAVKIttslgHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLS 919
|
250 260
....*....|....*....|....*..
gi 586186223 856 YQPNTPQGSIFYFYLTVNPIEMEGAMD 882
Cdd:PRK09959 920 LESHPGIGTTFTITIPVEISQQVATVE 946
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
767-872 |
3.16e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 77.92 E-value: 3.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALKHAEsHSEIKLHVQ-----HETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLY 841
Cdd:cd16922 1 LRQILLNLLGNAIKFTE-EGEVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 586186223 842 LVQLILKQHNSELEYQPNTPQGSIFYFYLTV 872
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
599-879 |
4.00e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 85.41 E-value: 4.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 599 VISIRFTDETYiDTYDNSILdSMLNDITlaiEnvdlLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKY 678
Cdd:COG5809 227 LLEASGAPIKK-NGEVDGIV-IIFRDIT---E----RKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKD 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 679 hNEHLNDQQQAELLTAsygEAQYLHTLVTNILSLTKLESSDIQIqrtpylVEELLEEFEEGLIRRHQANH----VIIENE 754
Cdd:COG5809 298 -TIDEEQKTYLDIMLS---ELDRIESIISEFLVLAKPQAIKYEP------KDLNTLIEEVIPLLQPQALLknvqIELELE 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 755 DDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQ-HETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKK 833
Cdd:COG5809 368 DDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFYT------TKE 441
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 586186223 834 DSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLtvnPIEMEG 879
Cdd:COG5809 442 KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL---PIKLSE 484
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-858 |
2.45e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 75.18 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALKHAesHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKkdSLGLGLYLVQLI 846
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS--GTGLGLAIVQRI 76
|
90
....*....|..
gi 586186223 847 LKQHNSELEYQP 858
Cdd:cd16950 77 SDAHGGSLTLAN 88
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
656-863 |
2.68e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 82.58 E-value: 2.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 656 HSISHDIRTPLTSIMGNLDMLkyhNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVEELLEE 735
Cdd:PRK11100 261 QTLTHELKSPLAAIRGAAELL---QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 736 FEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEER 815
Cdd:PRK11100 338 LVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYAL 417
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 586186223 816 QLIFNPYYSGDNfKDNKKDSLGLGLYLVQLILKQHNSELEYQpNTPQG 863
Cdd:PRK11100 418 PRIFERFYSLPR-PANGRKSTGLGLAFVREVARLHGGEVTLR-NRPEG 463
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
613-875 |
3.19e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 83.54 E-value: 3.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 613 YDNsiLDSMLNDITLAienvdlLKQTRQsilKAEREATR-SNFLHSISHDIRTPLTSIMGNLDMLKyhNEHLNDQQQaEL 691
Cdd:PRK15347 370 YDT--LENKVAERTQA------LAEAKQ---RAEQANKRkSEHLTTISHEIRTPLNGVLGALELLQ--NTPLTAEQM-DL 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 692 LTASYGEAQYLHTLVTNILSLTKLESSDI--QIQRTPYLVEELleefeeglirrhQANHVI-------------IENEDD 756
Cdd:PRK15347 436 ADTARQCTLSLLAIINNLLDFSRIESGQMtlSLEETALLPLLD------------QAMLTIqgpaqsksltlrtFVGAHV 503
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 757 ASLINIDSKLILQVLFNLIDNALKHAEsHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDnfkDNKKDSl 836
Cdd:PRK15347 504 PLYLHLDSLRLRQILVNLLGNAVKFTE-TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD---THSQGT- 578
|
250 260 270
....*....|....*....|....*....|....*....
gi 586186223 837 GLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLTVNPI 875
Cdd:PRK15347 579 GLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEY 617
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-863 |
2.20e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 72.74 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 773 NLIDNALKHaeSHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNS 852
Cdd:cd16949 7 NVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGG 84
|
90
....*....|.
gi 586186223 853 ELEYQPNTPQG 863
Cdd:cd16949 85 KIKASNRKPGG 95
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
636-876 |
7.11e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 78.86 E-value: 7.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 636 KQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLkyhNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKL 715
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIW---RQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRP 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 716 EssdiQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENEDDASL--INIDSKLILQVLFNLIDNALKHAESHSEIKLHVQ 793
Cdd:PRK11360 452 R----ESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINAVQAISARGKIRIRTW 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 794 HETN-KIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLTV 872
Cdd:PRK11360 528 QYSDgQVAVSIEDNGCGIDPELLKKIFDPFFT------TKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
....
gi 586186223 873 NPIE 876
Cdd:PRK11360 602 NPQG 605
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
635-870 |
8.37e-15 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 78.23 E-value: 8.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 635 LKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKYH---NEHLND-----QQQAELLT----------ASY 696
Cdd:COG5805 271 KKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGiedKEEYFDimlseLDRIESIIseflalakpqAVN 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 697 GEAQYLHTLVTNILSLTKLESSDIQIQrtpylveelleefeeglirrhqanhVIIENEDDASLINIDSKLILQVLFNLID 776
Cdd:COG5805 351 KEKENINELIQDVVTLLETEAILHNIQ-------------------------IRLELLDEDPFIYCDENQIKQVFINLIK 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 777 NALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHNSELEY 856
Cdd:COG5805 406 NAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFT------TKEKGTGLGLMVSYKIIENHNGTIDI 479
|
250
....*....|....
gi 586186223 857 QPNTPQGSIFYFYL 870
Cdd:COG5805 480 DSKVGKGTTFTITL 493
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
748-878 |
1.60e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.43 E-value: 1.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 748 HVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSE----IKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYY 823
Cdd:COG3290 263 DLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF 342
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 586186223 824 SgdnfkDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLtvnPIEME 878
Cdd:COG3290 343 S-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL---PKEGE 389
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
649-868 |
1.04e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 74.25 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 649 ATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEhlnDQQQAelLTASYGEaqyLHTLVTNILSLTKLESSDIQIQRTPYL 728
Cdd:PRK10604 210 ASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSA---AESQA--LNRDIGQ---LEALIEELLTYARLDRPQNELHLSEPD 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 729 VEELLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEmiDCGK 808
Cdd:PRK10604 282 LPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVE--DDGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 809 GIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYF 868
Cdd:PRK10604 360 GIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSF 419
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-866 |
4.03e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 66.29 E-value: 4.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 766 LILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfKDNKKDSLGLGLYLVQL 845
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT----TKPVGEGTGLGLSLSYR 78
|
90 100
....*....|....*....|.
gi 586186223 846 ILKQHNSELEYQPNTPQGSIF 866
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRF 99
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
651-717 |
4.43e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.93 E-value: 4.43e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586186223 651 RSNFLHSISHDIRTPLTSIMGNLDMLKyhnEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLES 717
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLR---DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-870 |
5.72e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 65.88 E-value: 5.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALkhaESHSEI-----KLHVQHETNK---IKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGL 838
Cdd:cd16920 1 IQQVLINLVRNGI---EAMSEGgcerrELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFYT------TKSEGLGM 71
|
90 100 110
....*....|....*....|....*....|..
gi 586186223 839 GLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:cd16920 72 GLSICRSIIEAHGGRLSVESPAGGGATFQFTL 103
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
648-714 |
6.49e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 64.16 E-value: 6.49e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586186223 648 EATRSNFLHSISHDIRTPLTSIMGNLDMLKyhNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTK 714
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLE--EELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-864 |
9.01e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.18 E-value: 9.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSlGLGLYL 842
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHY-GMGLYI 79
|
90 100
....*....|....*....|..
gi 586186223 843 VQLILKQHNSELeYQPNTPQGS 864
Cdd:cd16975 80 AKNLVEKHGGSL-IIENSQKGG 100
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
636-832 |
9.59e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 72.28 E-value: 9.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 636 KQTRQSILKAEREATRsnFLHSISHDIRTPLTSIMGNLDMLKyhNEHLNDQQQAELLTAsYGEAQYLHTLVTNILSLTKL 715
Cdd:PRK11091 270 KRYQDALEKASRDKTT--FISTISHELRTPLNGIVGLSRILL--DTELTAEQRKYLKTI-HVSAITLGNIFNDIIDMDKM 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 716 ESSDIQIQRTPylVEELLEEFEEGLIRRHQANH-----VIIENEDDASLINIDSKLILQVLFNLIDNALKHAEShSEIKL 790
Cdd:PRK11091 345 ERRKLQLDNQP--IDFTDFLADLENLSGLQAEQkglrfDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQ-GGVTV 421
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 586186223 791 HVQHETNK-IKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNK 832
Cdd:PRK11091 422 RVRYEEGDmLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGK 464
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
629-857 |
1.03e-12 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 71.05 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 629 IENVDLLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEHLNDQQQ-AELLTASYGEAQYlhtLVT 707
Cdd:COG5806 179 IENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQyIRIALEELDRAEA---IIT 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 708 NILSLTK-----LESSDI--QIQR-----TPYlveelleefeeglirrhqAN----HVIIENEDDAsLINIDSKLILQVL 771
Cdd:COG5806 256 DYLTFAKpqpekLEKIDVseELEHvidvlSPY------------------ANmnnvEIQTELEPGL-YIEGDRQKLQQCL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 772 FNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHN 851
Cdd:COG5806 317 INIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFS------TKEKGTGLGTMVSYRIIEAMN 390
|
....*.
gi 586186223 852 SELEYQ 857
Cdd:COG5806 391 GTIRVE 396
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
648-870 |
1.59e-12 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.42 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 648 EATRSNFLHSISHDIRTPLTSIMGNLDMLkyHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESS-DIQIQRT- 725
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYLEMM--QDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAApTIDLNEKv 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 726 --PylveelleefEEGLIRRHQA------NHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETN 797
Cdd:PRK11006 279 dvP----------MMLRVLEREAqtlsqgKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQ 348
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586186223 798 KIKFEMIDCGKGIPEE------ERqlifnpYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:PRK11006 349 GAEFSVEDNGPGIAPEhiprltER------FYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-870 |
2.12e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 64.23 E-value: 2.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKdSLGLGLYL 842
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYL 80
|
90 100
....*....|....*....|....*...
gi 586186223 843 VQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITF 108
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
651-717 |
1.06e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 60.66 E-value: 1.06e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586186223 651 RSNFLHSISHDIRTPLTSIMGNLDMLKyhNEHLNDQQQaELLTASYGEAQYLHTLVTNILSLTKLES 717
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLL--DTELSEEQR-EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-863 |
1.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 59.73 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHE-TNKIKFEmiDCGKGIPEEERQLIFNPYYSGDnfKDNKKDSlGLGLY 841
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADdGAVIRVE--DNGPGIDEEELEALFERFYRSD--GQNYGGS-GLGLS 84
|
90 100
....*....|....*....|..
gi 586186223 842 LVQLILKQHNSELEYQPNTPQG 863
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGG 106
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
648-865 |
1.20e-10 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 64.85 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 648 EATRSNFLHSISHDIRTPLTSIMGNLdmlkyhnEHLND---QQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQR 724
Cdd:NF012163 237 EQMRRDFMADISHELRTPLAVLRAEL-------EAIQDgirKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 725 TPYLVEELLEEFEEGLIRRHQANHVIIENE-DDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEM 803
Cdd:NF012163 310 ASVDLVPLLEVEGGAFRERFASAGLELEVSlPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTV 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 586186223 804 IDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPnTPQGSI 865
Cdd:NF012163 390 ADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAH-SPLGGL 450
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-863 |
1.96e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 58.60 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 770 VLFNLIDNALKHAESHSEIKLHVQHETNKIKFEmiDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQ 849
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVE--DDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90
....*....|....
gi 586186223 850 HNSELEYQpNTPQG 863
Cdd:cd16939 82 HGGHVECD-DSELG 94
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-863 |
2.16e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.63 E-value: 2.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKdSLGLGLYL 842
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAF 79
|
90 100
....*....|....*....|.
gi 586186223 843 VQLILKQHNSELEYQpNTPQG 863
Cdd:cd16945 80 VQEVAQLHGGRITLR-NRPDG 99
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
651-866 |
3.04e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 64.22 E-value: 3.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 651 RSNFLHSISHDIRTPLTSIMGNLDMLKYHNehLNdQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVe 730
Cdd:PRK10841 447 KSMFLATVSHELRTPLYGIIGNLDLLQTKE--LP-KGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREFSP- 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 731 elleefeeglirRHQANHVI-----------------IEnEDDASLINIDSKLILQVLFNLIDNALKHAESHSeIKLHVQ 793
Cdd:PRK10841 523 ------------REVINHITanylplvvkkrlglycfIE-PDVPVALNGDPMRLQQVISNLLSNAIKFTDTGC-IVLHVR 588
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586186223 794 HETNKIKFEMIDCGKGIPEEERQLIFNPYYS-GDNFKDNKKDSlGLGLYLV-QLI-LKQHNSELEYQPNTpqGSIF 866
Cdd:PRK10841 589 VDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvGTGVQRNFQGT-GLGLAICeKLInMMDGDISVDSEPGM--GSQF 661
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-871 |
2.23e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 55.37 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 773 NLIDNALKHA----ESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNkkdslGLGLYLVQLILK 848
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 586186223 849 QHNSELEYQPNTPQGSIFYFYLT 871
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
655-851 |
3.04e-09 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 60.33 E-value: 3.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 655 LHSISHDIRTPLTSI-MGNLDMLKYHNEhlndqqQAELlTASYGEAQYLHTLVTNILSLtklesSDIQIqrtpylveell 733
Cdd:PRK09470 247 LSDISHELRTPLTRLqLATALLRRRQGE------SKEL-ERIETEAQRLDSMINDLLVL-----SRNQQ----------- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 734 eefeegliRRHQANHVIIENE------DDASL-------------------INIDSKLILQVLFNLIDNALKHaeSHSEI 788
Cdd:PRK09470 304 --------KNHLERETFKANSlwsevlEDAKFeaeqmgksltvsappgpwpINGNPNALASALENIVRNALRY--SHTKI 373
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 586186223 789 KLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHN 851
Cdd:PRK09470 374 EVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHR 436
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-858 |
8.62e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 53.94 E-value: 8.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALKHA-ESHSEIKLH--VQHETN--------KIKFEMIDCGKGIPEEERQLIFNPYYSGdnfkdnKKDS 835
Cdd:cd16918 1 LIQVFLNLVRNAAQALaGSGGEIILRtrTQRQVTlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSG------RENG 74
|
90 100
....*....|....*....|....*
gi 586186223 836 LGLGLYLVQLILKQHNS--ELEYQP 858
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGviECDSQP 99
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
634-872 |
1.47e-08 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 58.76 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 634 LLKQTRQSILKAER-EATRSNFLHSISHDIRTPLTSIMGNLDMLKyHNEHLNdqQQAELLTASYGEAQYLHTLVTNILSL 712
Cdd:PRK11466 426 LVIEHRQARAEAEKaSQAKSAFLAAMSHEIRTPLYGILGTAQLLA-DNPALN--AQRDDLRAITDSGESLLTILNDILDY 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 713 TKLE--SSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIEN---EDDASLINIDSKLILQVLFNLIDNALKHAESHSe 787
Cdd:PRK11466 503 SAIEagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATdiaDDLPTALMGDPRRIRQVITNLLSNALRFTDEGS- 581
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 788 IKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnfKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFY 867
Cdd:PRK11466 582 IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ----VSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFC 657
|
....*
gi 586186223 868 FYLTV 872
Cdd:PRK11466 658 LRLPL 662
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-855 |
2.29e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.92 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHV--QHETN---KIKFEMIDCGKGIPEEERQLIFNPYYSgdnfkdNKKDSLG 837
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVriRVEADqdgRIVLIVCDNGKGFPREMRHRATEPYVT------TRPKGTG 74
|
90
....*....|....*...
gi 586186223 838 LGLYLVQLILKQHNSELE 855
Cdd:cd16944 75 LGLAIVKKIMEEHGGRIS 92
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-870 |
4.01e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 52.07 E-value: 4.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMI--DCGKGIPEEERQLIFNPYYSGdnfKDNKKdSLGLGLYLVQ 844
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVvrDNGPGIAEEHLSRVFDPFFTT---KPVGK-GTGLGLSISY 76
|
90 100
....*....|....*....|....*.
gi 586186223 845 LILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-870 |
6.09e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.43 E-value: 6.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 773 NLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNS 852
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*...
gi 586186223 853 ELEYQPNTPQGSIFYFYL 870
Cdd:cd16952 87 RLLIASELGKGSRFTCLF 104
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
618-850 |
6.12e-08 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 56.32 E-value: 6.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 618 LDSMLNDITLAIENVDLLKQTRQSILKAEREATR-SNFLHSISHDIRTPLTSIMGNLDMLKYHNEhlNDQQQAELLTASY 696
Cdd:PRK09835 228 LDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRqSNFSADIAHEIRTPITNLITQTEIALSQSR--SQKELEDVLYSNL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 697 GEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLID 776
Cdd:PRK09835 306 EELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLS 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 586186223 777 NALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQH 850
Cdd:PRK09835 386 NALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAH 459
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-856 |
8.40e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 51.86 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 744 HQANHVIIENE-DDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEmiDCGKGIPEEERQLIFNpy 822
Cdd:cd16954 14 YQRKGVSISLDiSPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVD--DDGPGVPESQRSKIFQ-- 89
|
90 100 110
....*....|....*....|....*....|....*...
gi 586186223 823 ysgdnfKDNKKDSL----GLGLYLVQLILKQHNSELEY 856
Cdd:cd16954 90 ------RGQRLDEQrpgqGLGLAIAKEIVEQYGGELSL 121
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-856 |
1.11e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 50.46 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 770 VLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNkkDSLGLGLYLVQLILKQ 849
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAIIEL 81
|
....*..
gi 586186223 850 HNSELEY 856
Cdd:cd16923 82 HGGSASA 88
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
763-865 |
1.17e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 50.92 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYL 842
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|...
gi 586186223 843 VQLILKQHNSELEYQPnTPQGSI 865
Cdd:cd16946 81 CHNIALAHGGTISAEH-SPLGGL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
648-854 |
1.91e-07 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 54.64 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 648 EATRSNFLHSISHDIRTPLTSIMGNLdmlkyhnEHLND---QQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQR 724
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGEL-------EAIQDgvrKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 725 TPYLVEELLEEFEEGLIRRHQANHVIIENE--DDASLINiDSKLILQVLFNLIDNALKHAESHS--EIKLHVQHETNKIK 800
Cdd:PRK10549 310 TPVDLVPLLEVAGGAFRERFASRGLTLQLSlpDSATVFG-DPDRLMQLFNNLLENSLRYTDSGGslHISAEQRDKTLRLT 388
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 586186223 801 FEmiDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSEL 854
Cdd:PRK10549 389 FA--DSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
635-854 |
2.09e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 54.69 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 635 LKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTK 714
Cdd:COG4192 417 LRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 715 LESSDIQiqrtPYLVEELLEEFEEGLIRRHQANHVIIENEDDAsLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQH 794
Cdd:COG4192 497 KSDTPLQ----PVDLRQVIEQAWELVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLS 571
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 795 ETNKIKFEMIDCGKGIPEEERqlIFNPYYSgdnfkdNKKDSLGLGLYLVQLILKQHNSEL 854
Cdd:COG4192 572 NAENLRVAISDNGNGWPLVDK--LFTPFTT------TKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-870 |
2.27e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 50.02 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 ILQVLFNLIDNALK--HAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYY---SGDNFKDNkkdslGLGLY 841
Cdd:cd16921 1 LGQVLTNLLGNAIKfrRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQrlhSREEYEGT-----GVGLA 75
|
90 100 110
....*....|....*....|....*....|.
gi 586186223 842 LVQLILKQH--NSELEYQPNtpQGSIFYFYL 870
Cdd:cd16921 76 IVRKIIERHggRIWLESEPG--EGTTFYFTL 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
658-863 |
3.81e-07 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 53.38 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 658 ISHDIRTPLTSIMGNLDMLKYHNEHLndqqqAELLTASYGEAQ--------YLHT---LVTNILSLTKLeSSDIQIQRTP 726
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMMSEEDGYL-----AESINKDIEECNaiieqfidYLRTgqeMPMEMADLNAL-LGEVIAAESG 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 727 YlveelleefeeglirrhqanHVIIENE--DDASLINIDSKLILQVLFNLIDNALKHaeSHSEIKLHVQHETNKIKFEMI 804
Cdd:PRK09467 310 Y--------------------EREIETAlqPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVE 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 586186223 805 DCGKGIPEEERQLIFNPYYSGDNFKDNkkDSLGLGLYLVQLILKQHNSELEYQpNTPQG 863
Cdd:PRK09467 368 DDGPGIPPEQLKHLFQPFTRGDSARGS--SGTGLGLAIVKRIVDQHNGKVELG-NSEEG 423
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
629-877 |
4.95e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 53.70 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 629 IENV--DLLKQTRQsilkaerEATR--SNFLHSISHDIRTPLTSIMG-NLDMLKyhnEHLNDQQQAELLTAsygE--AQY 701
Cdd:PRK11107 274 IQNVelDLAKKRAQ-------EAARikSEFLANMSHELRTPLNGVIGfTRQTLK---TPLTPTQRDYLQTI---ErsANN 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 702 LHTLVTNILSLTKLESSDIQIQRTPYLVeelleefeeglirRHQANHVII-----ENEDDASL-INIDSKL--------- 766
Cdd:PRK11107 341 LLAIINDILDFSKLEAGKLVLENIPFSL-------------RETLDEVVTllahsAHEKGLELtLNIDPDVpdnvigdpl 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 767 -ILQVLFNLIDNALKHAESHS-EIKLHVQHETN---KIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLY 841
Cdd:PRK11107 408 rLQQIITNLVGNAIKFTESGNiDILVELRALSNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLV 487
|
250 260 270
....*....|....*....|....*....|....*...
gi 586186223 842 LVQLILKQHNSELEY--QPNtpQGSIFYFYLTVNPIEM 877
Cdd:PRK11107 488 ITQKLVNEMGGDISFhsQPN--RGSTFWFHLPLDLNPN 523
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
749-875 |
5.64e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 52.78 E-value: 5.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 749 VIIENEDDASL--INIDSKLILQVLFNLIDNALKH-AESHSEIKL----------HVQHETNKIKFEMIDCGKGIPEEER 815
Cdd:PRK11073 218 VRLIRDYDPSLpeLAHDPDQIEQVLLNIVRNALQAlGPEGGTITLrtrtafqltlHGERYRLAARIDIEDNGPGIPPHLQ 297
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 816 QLIFNPYYSGdnfkdnKKDSLGLGLYLVQLILKQHNSELEYQpNTPQGSIFYFYLtvnPI 875
Cdd:PRK11073 298 DTLFYPMVSG------REGGTGLGLSIARNLIDQHSGKIEFT-SWPGHTEFSVYL---PI 347
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
749-866 |
7.31e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 49.05 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 749 VIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNF 828
Cdd:cd16947 3 VEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDS 82
|
90 100 110
....*....|....*....|....*....|....*...
gi 586186223 829 KDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIF 866
Cdd:cd16947 83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVF 120
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
763-850 |
9.51e-07 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 48.26 E-value: 9.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHSEIKLHVQ-HETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLY 841
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
....*....
gi 586186223 842 LVQLILKQH 850
Cdd:cd16925 81 IVKEFVELH 89
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
644-883 |
1.39e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 52.24 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 644 KAERE-----ATRSNFLHSISHDIRTPLTSIMGNLDMLKyhnEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESS 718
Cdd:PRK10618 438 QAQREyeknqQARKAFLQNIGDELKQPLQSLAQLAAQLR---QTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 719 DIQIQRTPYLVEE---LLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKhAESHSEIKLHVQHE 795
Cdd:PRK10618 515 DWKPEQELFSLQDlidEVLPEVLPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAIT-TTAYGKITLEVDQD 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 796 TN---KIKFEMIDCGKGIPEEERQLIFNPYYS---GDNFKDNKkdslGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFY 869
Cdd:PRK10618 594 ESspdRLTIRILDTGAGVSIKELDNLHFPFLNqtqGDRYGKAS----GLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIH 669
|
250
....*....|....
gi 586186223 870 LTVNPIEMEGAMDE 883
Cdd:PRK10618 670 LKMLAADPEVEEEE 683
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
761-870 |
1.71e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 51.76 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 761 NIDSKLILQVLFNLIDNA----LKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNpyySGDNFKDNKKDSL 836
Cdd:PRK15053 427 GLDSTEFAAIVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEH 503
|
90 100 110
....*....|....*....|....*....|....
gi 586186223 837 GLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYL 870
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFI 537
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-866 |
4.51e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 46.41 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 769 QVLFNLIDNALKHAESHS-EIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYS----GDNFKDNKkdslGLGLYLV 843
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTerpaNEAFGQHS----GLGLSIS 78
|
90 100
....*....|....*....|....*..
gi 586186223 844 QLILKQHN----SELEYQPNTPQGSIF 866
Cdd:cd16953 79 RQIIEAHGgisvAENHNQPGQVIGARF 105
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
751-867 |
1.69e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 48.37 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 751 IENEDDASLINidsKLIlQVLFNLIDNALKHAESHS--EIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSgdnf 828
Cdd:PRK11086 422 LPDSGDEDQVH---ELI-TILGNLIENALEAVGGEEggEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYS---- 493
|
90 100 110
....*....|....*....|....*....|....*....
gi 586186223 829 kdNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFY 867
Cdd:PRK11086 494 --TKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFF 530
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
765-850 |
4.58e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 46.93 E-value: 4.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 765 KLILQVLfnlIDNALKHAESHSE----IKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYysgdnfkDNKKDSLGLGL 840
Cdd:COG2972 338 KLILQPL---VENAIEHGIEPKEgggtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGL 407
|
90
....*....|
gi 586186223 841 YLVQLILKQH 850
Cdd:COG2972 408 RNVRERLKLY 417
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
768-818 |
6.23e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.10 E-value: 6.23e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 586186223 768 LQVLfnlIDNALKHA----ESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLI 818
Cdd:cd16957 6 LQVL---VENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL 57
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
768-854 |
6.61e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.08 E-value: 6.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 768 LQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEmiDCGKGIPEEERQLIFNpyysgdnfKDNKKDSL----GLGLYLV 843
Cdd:PRK10815 380 MEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVE--DDGPGIPESKRELIFD--------RGQRADTLrpgqGLGLSVA 449
|
90
....*....|.
gi 586186223 844 QLILKQHNSEL 854
Cdd:PRK10815 450 REITEQYEGKI 460
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
743-864 |
1.04e-03 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 42.26 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 743 RHQanHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPY 822
Cdd:PRK10755 226 RQQ--TLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAF 303
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 586186223 823 ------YSGdnfkdnkkdsLGLGLYLVQLILKQHNSELEYQpNTPQGS 864
Cdd:PRK10755 304 vrmdsrYGG----------IGLGLSIVSRITQLHHGQFFLQ-NRQERS 340
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
763-857 |
1.20e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 39.56 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 763 DSKLILQVLFNLIDNALKHAESHS---EIK-----------LHVQHetnkIKFEMIDCGKGIPEEERQLIFNPyySGDNF 828
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSPGgwvEIKvsptkkqigdgVHVIH----LEFRITHPGQGLPEELVQEMFEE--NQWTT 76
|
90 100
....*....|....*....|....*....
gi 586186223 829 KDnkkdslGLGLYLVQLILKQHNSELEYQ 857
Cdd:cd16932 77 QE------GLGLSISRKLVKLMNGDVRYL 99
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
774-866 |
5.34e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.27 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586186223 774 LIDNALKHA---ESHSEIKLHVQHETNKIKFEMIDCGKGIPEEerqliFNPYYSGdnfkdnkkdslGLGLYLVQLILKQH 850
Cdd:COG3920 407 LVTNALKHAflsGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPARK-----------GLGLRLIRALVRQL 470
|
90
....*....|....*.
gi 586186223 851 NSELEYqpNTPQGSIF 866
Cdd:COG3920 471 GGTLEL--DRPEGTRV 484
|
|
| |
