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Conserved domains on  [gi|586184695|gb|EWP90546|]
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protein sprT-like [Staphylococcus aureus M1204]

Protein Classification

SprT family zinc-dependent metalloprotease( domain architecture ID 10012201)

SprT family zinc-dependent metalloprotease, which contains an HExxH motif characteristic of zinc metallopeptidases

CATH:  3.30.2010.10
EC:  3.4.-.-
Gene Ontology:  GO:0008237|GO:0006508|GO:0046872

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK04351 PRK04351
SprT family protein;
1-151 5.85e-82

SprT family protein;


:

Pssm-ID: 235290  Cd Length: 149  Bit Score: 237.82  E-value: 5.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695   1 MNNDKLQRMVENLSEEKFGRTFRHCAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKG 80
Cdd:PRK04351   1 MTNQELQRLVEEISLEYFGKPFRHQAYFNKRLRTTGGRYLLKDHHIEFNPKMLEEYGLEELIGIIKHELCHYHLHLEGKG 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586184695  81 YQHKDQDFKRLSQQVGAPRFCNSIESyqQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK 151
Cdd:PRK04351  81 YQHRDRDFKELLKQVGGPRYCPPLPS--QKKNYLYECQSCGQQYLRKRRINTKRYRCGKCRGKLKLINQLK 149
 
Name Accession Description Interval E-value
PRK04351 PRK04351
SprT family protein;
1-151 5.85e-82

SprT family protein;


Pssm-ID: 235290  Cd Length: 149  Bit Score: 237.82  E-value: 5.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695   1 MNNDKLQRMVENLSEEKFGRTFRHCAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKG 80
Cdd:PRK04351   1 MTNQELQRLVEEISLEYFGKPFRHQAYFNKRLRTTGGRYLLKDHHIEFNPKMLEEYGLEELIGIIKHELCHYHLHLEGKG 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586184695  81 YQHKDQDFKRLSQQVGAPRFCNSIESyqQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK 151
Cdd:PRK04351  81 YQHRDRDFKELLKQVGGPRYCPPLPS--QKKNYLYECQSCGQQYLRKRRINTKRYRCGKCRGKLKLINQLK 149
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
4-147 6.86e-45

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 144.00  E-value: 6.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695     4 DKLQRMVENLSEEKFGRTFRHC-AYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKGYQ 82
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPkVVWNKRLRKTGGRCLLKSAEIRLNPKLLTENGRDRLRETLLHELCHAALYLFGRGYG 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586184695    83 HKDqDFKRLSQQVGAP---RFCNSIESYQQRanYEYYCTKCHAKYIRIRKV-DTNRMRCGHCNGKLRMK 147
Cdd:smart00731  81 HGD-EWKRWMRQVNGLfpeRCHTFLIESVKK--YPYRCTGCGQRYLRVRRSnNVSRYRCGKCGGKLILI 146
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
1-145 3.08e-41

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 135.02  E-value: 3.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695   1 MNNDKLQRMVE---NLSEEKFGRTFRHC-AYFNKRlRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHI 76
Cdd:COG3091    3 MLQQELQRRVEqilQLAEEYFGRPFPHPeVRFNLR-GTTAGRAHLQSHEIRLNPKLLEENGEEFLIEVVPHELAHYHLYQ 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586184695  77 AGKGYQHKDQDFKRLSQQVGA--PRFCNSIESYQ-QRANYEYYCtKC-HAKYIRIRKVDTNR---MRCGHCNGKLR 145
Cdd:COG3091   82 EFGRVRPHGKEWRELMEKVGGlpPRRTHRFDVSSvQGKRYLYRC-ACgQHQLSRRRHNNVLRgarYRCRKCGGKLK 156
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
6-100 6.21e-19

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 76.54  E-value: 6.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695    6 LQRMVENLSEEKFGR--TFRHCAYFNKRLRTTGGRYLLKS-HDIEINPKQYEHYGEDAVVKIILHELCHYHLHIA-GKGY 81
Cdd:pfam10263   1 LEELFQQLNDEFFRGflLPGVSVRWSKRLRTTAGRAHLKRkNEIRLSEPLLDENPEEFLRETLLHEMIHAYLFVLfGRRR 80
                          90
                  ....*....|....*....
gi 586184695   82 QHkDQDFKRLSQQVGAPRF 100
Cdd:pfam10263  81 GH-GPEFKAWMERINEAQT 98
 
Name Accession Description Interval E-value
PRK04351 PRK04351
SprT family protein;
1-151 5.85e-82

SprT family protein;


Pssm-ID: 235290  Cd Length: 149  Bit Score: 237.82  E-value: 5.85e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695   1 MNNDKLQRMVENLSEEKFGRTFRHCAYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKG 80
Cdd:PRK04351   1 MTNQELQRLVEEISLEYFGKPFRHQAYFNKRLRTTGGRYLLKDHHIEFNPKMLEEYGLEELIGIIKHELCHYHLHLEGKG 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586184695  81 YQHKDQDFKRLSQQVGAPRFCNSIESyqQRANYEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKRQLK 151
Cdd:PRK04351  81 YQHRDRDFKELLKQVGGPRYCPPLPS--QKKNYLYECQSCGQQYLRKRRINTKRYRCGKCRGKLKLINQLK 149
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
4-147 6.86e-45

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 144.00  E-value: 6.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695     4 DKLQRMVENLSEEKFGRTFRHC-AYFNKRLRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHIAGKGYQ 82
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPkVVWNKRLRKTGGRCLLKSAEIRLNPKLLTENGRDRLRETLLHELCHAALYLFGRGYG 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586184695    83 HKDqDFKRLSQQVGAP---RFCNSIESYQQRanYEYYCTKCHAKYIRIRKV-DTNRMRCGHCNGKLRMK 147
Cdd:smart00731  81 HGD-EWKRWMRQVNGLfpeRCHTFLIESVKK--YPYRCTGCGQRYLRVRRSnNVSRYRCGKCGGKLILI 146
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
1-145 3.08e-41

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 135.02  E-value: 3.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695   1 MNNDKLQRMVE---NLSEEKFGRTFRHC-AYFNKRlRTTGGRYLLKSHDIEINPKQYEHYGEDAVVKIILHELCHYHLHI 76
Cdd:COG3091    3 MLQQELQRRVEqilQLAEEYFGRPFPHPeVRFNLR-GTTAGRAHLQSHEIRLNPKLLEENGEEFLIEVVPHELAHYHLYQ 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586184695  77 AGKGYQHKDQDFKRLSQQVGA--PRFCNSIESYQ-QRANYEYYCtKC-HAKYIRIRKVDTNR---MRCGHCNGKLR 145
Cdd:COG3091   82 EFGRVRPHGKEWRELMEKVGGlpPRRTHRFDVSSvQGKRYLYRC-ACgQHQLSRRRHNNVLRgarYRCRKCGGKLK 156
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
6-100 6.21e-19

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 76.54  E-value: 6.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586184695    6 LQRMVENLSEEKFGR--TFRHCAYFNKRLRTTGGRYLLKS-HDIEINPKQYEHYGEDAVVKIILHELCHYHLHIA-GKGY 81
Cdd:pfam10263   1 LEELFQQLNDEFFRGflLPGVSVRWSKRLRTTAGRAHLKRkNEIRLSEPLLDENPEEFLRETLLHEMIHAYLFVLfGRRR 80
                          90
                  ....*....|....*....
gi 586184695   82 QHkDQDFKRLSQQVGAPRF 100
Cdd:pfam10263  81 GH-GPEFKAWMERINEAQT 98
Zn_ribbon_SprT pfam17283
SprT-like zinc ribbon domain; This family represents a domain found in eukaryotes and ...
113-148 8.90e-08

SprT-like zinc ribbon domain; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc ribbon. This family includes the bacterial SprT protein.


Pssm-ID: 465398  Cd Length: 38  Bit Score: 45.76  E-value: 8.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 586184695  113 YEYYCTKCHAKYIRIRKVDTNRMRCGHCNGKLRMKR 148
Cdd:pfam17283   3 YVYRCPSCGREYPRHRRSDRHNYRCRRCKGTLGQTT 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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