|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
1-374 |
1.37e-40 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 147.41 E-value: 1.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17391 16 APFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLIL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA---------LLMSIAVITFI 151
Cdd:cd17391 96 RLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNvffitggllFLAFLLTLFFV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 152 VCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFamygmltaLSPLASSVNHTAIddrsVIG 231
Cdd:cd17391 176 KEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLY--------IRQLMGDASNLAF----ISG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 232 FLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACH 311
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITP 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 581842029 312 QQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYttpattfIVMGVVFAVSSLFLICSTITNQIN 374
Cdd:cd17391 324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAH-------FGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-365 |
1.74e-37 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 139.25 E-value: 1.74e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17325 16 IPILPLYAESL-GASVAQI----GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIvCIFGALK 159
Cdd:cd17325 91 RFLQGLASAAVWPAAMALIADIAPPEeRGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWT 239
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL---SPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 581842029 320 GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-330 |
5.59e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 5.59e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLqNLSVVEIQLwsgiAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:COG2814 30 LPALPLIAADL-GASPAQAGL----VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALK 159
Cdd:COG2814 105 RFLQGLGAGALFPAALALIADLVPPErRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQtpninkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWT 239
Cdd:COG2814 185 LPESRPAARAR-------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL---SASAAGLLLALFGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:COG2814 255 GGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334
|
330
....*....|.
gi 581842029 320 GTTNSMLVVGQ 330
Cdd:COG2814 335 GLYNSAFFLGG 345
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
1-357 |
7.64e-27 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 110.39 E-value: 7.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:PRK09874 34 MPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIvCIFGALKL 160
Cdd:PRK09874 114 RALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFL-CFLVTLFC 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 161 IETTHMPKSQTPNINkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALS----PLASSVNHTAIddrsVIGFLQSA 236
Cdd:PRK09874 193 IRENFQPVSKKEMLH--MREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTlyvrELAGNVSNIAF----ISGMIASV 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 237 FWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKG 316
Cdd:PRK09874 267 PGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAG 346
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 581842029 317 TFVGTTNSMLVVGQIIGSLSGAAIT-SYTTPATTFIVMGVVF 357
Cdd:PRK09874 347 RIFSYNQSFRDIGNVTGPLMGAAISaNYGFRAVFLVTAGVVL 388
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-334 |
2.49e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.41 E-value: 2.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAP-AEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALK 159
Cdd:pfam07690 92 RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQTPNINKGIRRSFQCLLcTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDdrsvIGFLQSAFWT 239
Cdd:pfam07690 172 RPPPESKRPKPAEEARLSLIVAWKALL-RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL----AGLLLGLGGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDK---SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKG 316
Cdd:pfam07690 247 LGAIGRLLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERG 326
|
330
....*....|....*...
gi 581842029 317 TFVGTTNSMLVVGQIIGS 334
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
1-364 |
5.79e-21 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 93.03 E-value: 5.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIQlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17330 16 FPVLPFYVREFNKLGASGYY--VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFgalkl 160
Cdd:cd17330 94 RFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 161 ietthmpksqtpninkgirrsfqCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHtaiDDRSVIGFLQSAFWTA 240
Cdd:cd17330 169 -----------------------VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFG---FSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 241 SILS-APLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:cd17330 223 GILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 581842029 320 GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFL 364
Cdd:cd17330 303 GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-364 |
1.15e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.49 E-value: 1.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVveiqlWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd06174 16 SPLLPALLQSFGLSAS-----QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFS--ALLMSIAVITFIVCIFGA 157
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAALALLAAILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 158 LKLIETTHMPKSQT-PNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIddrSVIGFLQSA 236
Cdd:cd06174 171 LVVPDPPESARAKNeEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV---AVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 237 FWTASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLK 315
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 581842029 316 GTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFL 364
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-365 |
2.37e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 91.50 E-value: 2.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVeiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17489 16 LPVLPLYAHDLGGSEAV-----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGAlk 159
Cdd:cd17489 91 RLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQTPNINKGIRRSFQCLLCTqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHtaiddrSVIGFLQSAFWT 239
Cdd:cd17489 169 LVKDPPPVAAEEAEAGTRAFRRLVEKKVL----PPALILFLASIAYGAISTFLPLYAAERGI------SNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 581842029 320 GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-365 |
1.49e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.16 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEA 102
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 103 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFgalklietthmpksqtpninkgirrsf 182
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL--------------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 183 qcllctqQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDK--SYVKSV 260
Cdd:COG2271 181 -------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL---SLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 261 YIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAI 340
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
330 340
....*....|....*....|....*
gi 581842029 341 TSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
23-365 |
2.10e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 2.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 23 SGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAE 101
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 102 APAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNInkgirRS 181
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLL-----SS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 182 FQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVY 261
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF---SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 262 IFATIACGCSAILQGLATNIEFLMAARILQGLTYSAlIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAIT 341
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFA-AHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
|
330 340
....*....|....*....|....
gi 581842029 342 SYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17324 347 DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-365 |
1.33e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.53 E-value: 1.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAP 103
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 104 AED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSF 182
Cdd:COG2223 123 PPDrRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 183 QcllcTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHtaiDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYI 262
Cdd:COG2223 203 R----DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG---LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 263 FATIACGCSAILQGLAT-NIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAIT 341
Cdd:COG2223 276 IVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
330 340
....*....|....*....|....*
gi 581842029 342 SYT-TPATTFIVMGVVFAVSSLFLI 365
Cdd:COG2223 356 DATgSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
2-366 |
2.20e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 2.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 2 PLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:cd17474 20 PILPAIAEAL-GASPAQV----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVItfIVCIFGALKL 160
Cdd:cd17474 95 ALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALI--PVAFLAILFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 161 IETthmPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLAssvNHTAIDDRSVIGFLQSAFWTA 240
Cdd:cd17474 173 LPE---PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL---ELLYGISPIIIGLLFAGWSVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 241 SILSAPLWGRFNDKSY-VKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:cd17474 247 LALGSLFVGRLLKKRFgARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 581842029 320 GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLIC 366
Cdd:cd17474 327 SLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-367 |
5.31e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 72.65 E-value: 5.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 21 LWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCT-----TPLQFVLVRLLQGLFGGVVDASS 95
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 96 AFASAEAPAEDR-GKVLGRLQSSVSAGSLVGPLIGGVTASILGFsALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNI 174
Cdd:cd06173 114 QALLPELVPKEQlVRANALNSLATQLARIIGPALGGLLVALLGP-GGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 175 NKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAidDRSVIGFLQSAFWTASILSAPLWGRFNDK 254
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG--GAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 255 SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGS 334
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
330 340 350
....*....|....*....|....*....|...
gi 581842029 335 LSGAAITSYTTPATTFIVMGVVFAVSSLFLICS 367
Cdd:cd06173 351 LLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-365 |
1.87e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.71 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 21 LWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFAS 99
Cdd:cd17316 36 LQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 100 AEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMsiavITFIVCIFGALKLIetthmpksqtpninkGIR 179
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWR----ILFLIGALPALLAL---------------LLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 180 RSFQCLlctqqtcrfIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWtasILSAPLWGRFNDKSYVKS 259
Cdd:cd17316 177 RRTLLL---------ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA---LVGALIAGLLSDRIGRKK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 260 VYIFATIACGCSAIL--QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSG 337
Cdd:cd17316 245 TLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI 324
|
330 340
....*....|....*....|....*...
gi 581842029 338 AAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
194-365 |
1.65e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.08 E-value: 1.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 194 FIIVGVLANFAMYGMLTALSPLASSVNHTAiddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 273
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASP----AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 274 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVM 353
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|..
gi 581842029 354 GVVFAVSSLFLI 365
Cdd:COG2814 171 AVLALLALLLLL 182
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-365 |
8.67e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.10 E-value: 8.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASiLGFSALLMSIAVITFIVCIFGALK 159
Cdd:cd17329 95 LVLTGFGGGLFEPASEAMIADVTTPEnRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETThmpKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLAnFAMYGMLTalSPLASSVNHTAIDDRSVIGFLQSAFWT 239
Cdd:cd17329 174 LPETR---PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLI-SLIYFQLE--STLPVYVVEILGLGESLLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFV 319
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYM 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 581842029 320 GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17329 328 GFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-365 |
1.94e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 1.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 19 IQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFA 98
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 99 SAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASI---LGFSALLMSIAVItfivcIFGALKLIETthMPKSQTPNI 174
Cdd:cd17473 113 IGDYFEGEeRAKMLGLQSAAMSLGGVVFLLLGGALAEIgwrAPFLVYLLALPVL-----ILVLLFLPEP--ARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 175 NKGIRRSFQCLLCTQQTCrfiIVGVLANFAMYGMLTALSPLassVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDK 254
Cdd:cd17473 186 PGAATAAALPWKRVLPIY---FLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 255 SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGS 334
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
|
330 340 350
....*....|....*....|....*....|..
gi 581842029 335 L-SGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17473 340 LvLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
193-363 |
3.81e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.74 E-value: 3.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 193 RFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSA 272
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 273 ILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIV 352
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170
....*....|.
gi 581842029 353 MGVVFAVSSLF 363
Cdd:COG2271 170 LGLPGLLLALL 180
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-363 |
7.75e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 7.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 23 SGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEA 102
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 103 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASI---LGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIR 179
Cdd:COG0738 125 GPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 180 RSFQcllctqqtCRFIIVGVLANFAMYGMLTALSPLASSVNHTAID-DRSVIGFLQSAFWTASILSAPLWGRFNDK-SYV 257
Cdd:COG0738 205 SLLK--------NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRfGPV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 258 KSVYIFATIACGCSAILqGLATNIEFLMAARILQGLTYSaLIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSG 337
Cdd:COG0738 277 RLLRLSALLAAVGLLLA-LLAPGPWLALIGLALVGLGLS-LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLI 354
|
330 340
....*....|....*....|....*.
gi 581842029 338 AAITSYTTPATTFIVMGVVFAVSSLF 363
Cdd:COG0738 355 GFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
194-365 |
3.17e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 60.89 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 194 FIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 273
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGI---SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 274 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVM 353
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170
....*....|..
gi 581842029 354 GVVFAVSSLFLI 365
Cdd:pfam07690 158 AILSLLAAVLLL 169
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-163 |
3.12e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.51 E-value: 3.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 22 WSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASA- 100
Cdd:COG0477 50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAe 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 581842029 101 EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMsIAVITFIVCIFGALKLIET 163
Cdd:COG0477 130 LFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL-INAPLGLLALVLRLRLPES 191
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-369 |
3.25e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKW-----MVLRALLGLAVCLFLMALCTTPL 75
Cdd:COG2211 30 SAYLLYFYTDVLGLSAALV----GLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 76 Q------FVLVRLLQGLFGGVVDA--SSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA-----LL 142
Cdd:COG2211 106 PtgkliyALVTYLLLGLAYTLVNIpySALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgyrLT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 143 MSIAVITFIVCIFGALKLIETTHMPKSQTPNinkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHt 222
Cdd:COG2211 186 ALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLG- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 223 aiDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLA--TNIEFLMAARILQGLTYsALIQ 300
Cdd:COG2211 261 --LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGL-GAIL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 301 SVMFVVVNAC--------HQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYT--------TPATTFIVMGVVFAVSSLFL 364
Cdd:COG2211 338 VLPWAMLADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqSPSALTGIRLLFFLLPAVLL 417
|
....*
gi 581842029 365 ICSTI 369
Cdd:COG2211 418 LLAAL 422
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-365 |
5.97e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 5.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLqNLSVVEIQLWSGIAIAAPAVTTMIAspiwGKLGDKISRKWMVlrALLGLAVCLF---LMALCTTPLQF 77
Cdd:cd17370 19 RSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFS----GYLSDRTGKRKPL--VILGYGLSALakpLLALAGSWQLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 78 VLVRLL----QGLFGGVVDASSAFASAEApaeDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFS-----ALLMSIAVI 148
Cdd:cd17370 92 LLLRILerlgKGIRTPPRDALLADATPPS---GRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrtifLLAAIPALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 149 TFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQcllctqqtcRFIIVGVLANFAMYGMltALSPLASSVNHTAIddrS 228
Cdd:cd17370 169 ALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFW---------LYLLAVALFALGNFSF--AFLILRAQELGLSA---A 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 229 VIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLtYSALIQSVM-FVVV 307
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL-YMGAQESIErAAVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 581842029 308 NACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
25-369 |
1.10e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.43 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 25 IAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASA-EAP 103
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRdLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 104 AEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVcIFGALKLIETTHMPKSQTPNInKGIRRSFQ 183
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLL-LLLVLLFLPETLPEEKRKPLL-SSLLRAYK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 184 CLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIF 263
Cdd:cd17320 196 RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL---SPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 264 ATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSY 343
Cdd:cd17320 273 GLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGL 352
|
330 340
....*....|....*....|....*.
gi 581842029 344 tTPATTFIVMGVVFAVSSLFLICSTI 369
Cdd:cd17320 353 -LPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
1-365 |
1.79e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 55.72 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQnLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17388 19 MPVLPTLLREFV-GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASIlGFSALLMSIAVITFIVCIFGALKL 160
Cdd:cd17388 98 RIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 161 IEtTHMPKSQTPNINKGIR--RSFQCLlctqqtcrFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDR-----SVIGFL 233
Cdd:cd17388 177 PE-SLPPERRRAFRWRRANpfGSLRWL--------TGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRfdwspTMVGLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 234 QSAFWTASILS-APLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARI---LQGLTYSALiQSVMFVVVNA 309
Cdd:cd17388 248 LAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILIllaLGGIAGPAL-QGLLSRQVPE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 310 CHQ-QLKGTFVGTTNsmlvVGQIIGSLSGAAITSYTT---PATTFIVMGVVFAVSSLFLI 365
Cdd:cd17388 327 NEQgELQGVLTSLTS----LTSIIGPLLFTGIFAASPatwPGLAWIIGAALYLICLVLAY 382
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
2-160 |
2.18e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 55.70 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 2 PLLPIYMASLQNlSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:PRK09874 240 PILTLYVRELAG-NVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILR 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL 160
Cdd:PRK09874 319 FLLGAAdGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSL 398
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
1-367 |
6.76e-08 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 53.77 E-value: 6.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSVVeiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17390 16 LPLLSTHIRSLGASPTV-----IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGG-VTASILGFsallmsiavitFIVCIFGALK 159
Cdd:cd17390 91 RIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhLAETDGGF-----------YYVALLCSAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIetthmpksqtpnINKGIrrsfqcllctqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHTAI------DDRSVIGFL 233
Cdd:cd17390 160 FI------------LNAGL--------------VWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYleerfdLSPKTIGYL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 234 QSAFWTASILSAPLWGR---FNDKSYVKSVYIFATIACgCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNAC 310
Cdd:cd17390 214 ISYSGVLGALSGFLVGRilkLYKNNEYLLLLHSFILLA-LSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRG 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 581842029 311 HQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLICS 367
Cdd:cd17390 293 KSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
194-365 |
1.42e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 194 FIIVGVLANFAMYGMLTALSPLASSVNHTAiddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 273
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSA----SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 274 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPA--TTFI 351
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFL 156
|
170
....*....|....
gi 581842029 352 VMGVVFAVSSLFLI 365
Cdd:cd06174 157 IAAALALLAAILLL 170
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-364 |
1.57e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.57 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 36 IASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRL 114
Cdd:cd17319 53 LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 115 QSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLietthmpksqtpninkgirrsfqcllctQQTCRF 194
Cdd:cd17319 133 NSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL----------------------------RQVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 195 IIVGVLANFAMYGMLTALSPLassVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAIL 274
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTY---LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 275 QGLATNIEFLMAARILQGLTYSAL--IQSVMFVVVN-ACHQQLKGTFVGTTNSMLVVGQIIGSLS-GAAIT---SYTTPA 347
Cdd:cd17319 262 LLLAYLTTSPVVAVILLSLAGFGIgaASPVFWSLPAdLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDatgSYTAAF 341
|
330
....*....|....*..
gi 581842029 348 TTFIVMGVVFAVSSLFL 364
Cdd:cd17319 342 LFLAAVALLAALLVLLL 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
193-365 |
1.68e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.12 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 193 RFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSA 272
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 273 ILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIV 352
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|...
gi 581842029 353 MGVVFAVSSLFLI 365
Cdd:COG0477 174 NAPLGLLALVLRL 186
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
32-365 |
3.41e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.41 E-value: 3.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 32 VTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKV 110
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPReRGKY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 111 LGRLQSSVSAGSLVGPLIGGVTASILGFSAllmsiavITFIVCIFGALKLIetthmpksqtpninkgIRRSFQCLLctqq 190
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIGGAFTDHLSWRW-------CFYINLPIGGLALA----------------LLRTILLSS---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 191 tcrfiIVGVLANFAMYGMLTALSPLASSV-NHTAIDDrsviGFLQSAFWTASILSAPLWGRFNDKS-YVKSVYIFATIAC 268
Cdd:cd17502 174 -----IFGFLFGGALFGLIYYLPLYFQLVlGDSATKS----GVRLLPLIIGLVIGSIISGALISKTgRYKPLIVIGTILM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 269 GCSAIL---QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNAchqqLKGTFVGTTNSMLVVGQIIGSLSGAAITsytt 345
Cdd:cd17502 245 SVGAGLlttLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNA----VPPADVGVATATNTFFRSLGGTLGVAIT---- 316
|
330 340
....*....|....*....|
gi 581842029 346 paTTFIVMGVVFAVSSLFLI 365
Cdd:cd17502 317 --DVFLVALALAALAFLLSL 334
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-160 |
7.22e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 7.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEA 102
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVDLV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 581842029 103 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL 160
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-365 |
7.78e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 2 PLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:cd17478 17 ALLPLLIAKL-GLSYAQA----GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA--LLMSIAVITFIVCIFGALK 159
Cdd:cd17478 92 ALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGllILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQTPNINKGIRRSFQCLLctqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHTAIddrsVIGFLQSAFWT 239
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALL------LLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV----FAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 240 ASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALiqSVMFVVVnachQQLKGTFV 319
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF--PVTVVLA----QELLPGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 581842029 320 GTTNS-MLVVGQIIGSLSGAAITS---YTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17478 316 GLASGlMMGLSFGLGGIGAPVLGAladAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
230-370 |
1.03e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.25 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 230 IGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNA 309
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 581842029 310 CHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTF----IVMGVVFAVSSLFLICSTIT 370
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFyinlPIGGLALALLRTILLSSIFG 176
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
24-366 |
1.27e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDK-ISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEA 102
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREY 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 103 PAEDRGK----VLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVItFIVCIFGALKLIETTHMPKSQTPNINKGI 178
Cdd:cd17471 115 ADRSSGRdatlFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALL-YLVVALLVLFLLPSVKPPAQKATPASSLV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 179 RRSFQcllctQQTCRFIIVGVLANFAMYGMLTALsPLAsSVNHTAIDDRSViGFLqsaFWTASILSAP---LWGRFNDKS 255
Cdd:cd17471 194 KAPVN-----RRLLLLFAAFTLLFAANSMYIIAM-PLY-VTNELGGSESWV-GLL---FGLAAALEIPimlLAGLLAKRF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 256 YVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVvnachQQLKGTFVGTT----NSMLVVGQI 331
Cdd:cd17471 263 GKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYF-----QDLMPGQPGLAttlySNASRIGSL 337
|
330 340 350
....*....|....*....|....*....|....*
gi 581842029 332 IGSLSGAAITSYTTPATTFIVMgVVFAVSSLFLIC 366
Cdd:cd17471 338 LGGLLAGVIAQYFGYRAVFLVC-AVLALLALVLLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
228-365 |
1.69e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 228 SVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVV 307
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 581842029 308 NACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17324 114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLW 171
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
32-352 |
2.73e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.73 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 32 VTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVL 111
Cdd:cd17504 42 LVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 112 GRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIfgALKLIETTHMPKSQTPNINkgirrsfqcllctqqt 191
Cdd:cd17504 122 GILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA--LVPLIDLRLLRRRNVLLAN---------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 192 crfiIVGVLANFAMYGMLTALS-PLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDK-SYVKSVYIFATIACG 269
Cdd:cd17504 184 ----ITALLAGFGMFMVFQLLPqLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvGPRRVLLIGLVISAV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 270 CSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGS-LSGAAITSYTTPAT 348
Cdd:cd17504 260 GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPaIAGAILTTYTVSIT 339
|
....
gi 581842029 349 TFIV 352
Cdd:cd17504 340 SGGV 343
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
2-153 |
4.33e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 48.34 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 2 PLLPIYMasLQNLSVVEIQLwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:cd17384 215 PCLPIWM--METMCPPKWQL--GTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPH 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581842029 82 LLQGLFGGVVDASSAFASAEAPAEDRGKVLGRL----QSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVC 153
Cdd:cd17384 291 FGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVyaiaDVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYA 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
188-369 |
7.07e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 7.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 188 TQQTCRFIIVGVLANFAMYGMLTALspLASSVNHTAID---DRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFA 264
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATAL--WGPLIPALKDAfglSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 265 TIACGCSAILQGLATNIEFLMAARILQGLTySALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYT 344
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158
|
170 180
....*....|....*....|....*...
gi 581842029 345 TPATT---FIVMGVVFAVSSLFLICSTI 369
Cdd:COG0738 159 LSLSWhlpYLILAVLLLLLALLFLRSKL 186
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
203-364 |
7.15e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.57 E-value: 7.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 203 FAMYGMLTALSPLASSVNHTAIDD--------RSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAIL 274
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQiaedfhvsEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 275 QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTF---- 350
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwfla 160
|
170
....*....|....
gi 581842029 351 IVMGVVFAVSSLFL 364
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
1-365 |
7.17e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 7.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQ-NLSVVeiqlwsGIAIAAPAVTTMIASPIWGKLGDKI-SRKWMVLRALLGLAVCLFLMALCTTPLQFV 78
Cdd:cd17490 16 VPFLSPYAESLGaSLSMI------GIILGAYGISQMLLRIPLGILSDRIgKRKLFIIIGLLFTVLASLIMILFPSPWGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 79 LVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAL-LMSI--AVITFIVCIF 155
Cdd:cd17490 90 IARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPfLLAAlaGVLGFILSLF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 156 galklIETTHMPKSQTPNINKGIRRsfqclLCTQQTCRFI-IVGVLANFAMYGMLTALSPL-ASSVNHTAIDdrsvIGFL 233
Cdd:cd17490 170 -----IKEERREKKPVLTELKELLS-----VLKDKKLLFFsLLAILQQMITFSTTFGFTPLiAKQLGASSFQ----LGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 234 QSAFWTASILSAPLWGRFNDKSY-VKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQ 312
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFYKKLgERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 581842029 313 QLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17490 316 EQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-342 |
7.26e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 7.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 39 PIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGG-VVDASSAFASAEAPAEDRGKVLGRLQSS 117
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 118 VSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVcifgalklietthmpksqtpninkgirrsfqcLLCTQQTCRFIIV 197
Cdd:cd17321 129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA--------------------------------LLLARTFSGAVLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 198 GVLANFAMYGMLTALSPLASSVNHtaiDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQ-- 275
Cdd:cd17321 177 AFLLGAALGGLLFLLPLYLQGVLG---YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLal 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 581842029 276 -GLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIG-SLSGAAITS 342
Cdd:cd17321 254 lGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvALLGALLTA 322
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
228-366 |
8.12e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.19 E-value: 8.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 228 SVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALiqSVMFVVV 307
Cdd:cd17330 34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV--SVAQAYI 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 308 NACHQQLKGTFV-GTTNSMLVVGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLIC 366
Cdd:cd17330 112 ADITDEEERAKAfGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-364 |
8.53e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.56 E-value: 8.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 2 PLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:COG2807 39 PLLPEIRADL-GLSATQA----GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLI 161
Cdd:COG2807 114 ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 162 ETTHMPKSQTPninkgiRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAiddrSVIGFLQSAFWTAS 241
Cdd:COG2807 194 RRPAAAAAAPA------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSA----ATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 242 ILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALI-QSVMFVVVNACHQQLKGTFVG 320
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFpLALTLIGLRARTPAEAAALSG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 581842029 321 TTNSMLVVGQIIGSLSGAAI----TSYTTPATTFIVMGVVFAVSSLFL 364
Cdd:COG2807 344 MAQSVGYLLAALGPLLVGALhdatGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-163 |
1.29e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 4 LPIYMASLQNLSVVEiqlwSGIAIAAPAVTTMIASPIWGKLGDKISR--KWMVLRALLGLAVCLFLMALCTTPLQFVLVR 81
Cdd:COG2271 203 LPTYLVEVRGLSLAQ----AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL 160
Cdd:COG2271 279 FLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
...
gi 581842029 161 IET 163
Cdd:COG2271 359 RET 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-152 |
1.76e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 4 LPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLL 83
Cdd:cd17473 220 LPFLLQERGGGS----AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAIL 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 581842029 84 QGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLI--------GGVTASILGFSALLMSIAVITFIV 152
Cdd:cd17473 296 AGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlgplvnltGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-159 |
2.06e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 3 LLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRL 82
Cdd:cd06173 230 LLPLLAKEVLGGGAAGY----GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 581842029 83 LQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALK 159
Cdd:cd06173 306 LLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-162 |
2.29e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 4 LPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQ--FVLVR 81
Cdd:COG2223 228 LPPYLVDQFGLSAATA----GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWlfLVLFL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 82 LLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLI 161
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
.
gi 581842029 162 E 162
Cdd:COG2223 384 R 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-364 |
2.42e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.11 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 22 WSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF--GGVVDASSAFAS 99
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgaGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 100 AEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGF-SALLMSIAVITFIVCIFGALKLIET-THMPKSQTPNINKG 177
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrTALLVLALLALLVLVPVLLLLRRRPaDLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 178 IRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFnDKSYV 257
Cdd:cd17355 199 PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 258 KSVYIFATiACGCSAILQGLATNIEFLMAArILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSG 337
Cdd:cd17355 278 LAASYALR-ALGLALLLLLPFPPLALLLFA-ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLG 355
|
330 340 350
....*....|....*....|....*....|.
gi 581842029 338 AAIT----SYTTPATTFIVMGVVFAVSSLFL 364
Cdd:cd17355 356 GLLYdrtgSYTAAWALAVALGLIAALLVLPI 386
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
1-74 |
2.59e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 46.22 E-value: 2.59e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 581842029 1 MPLLPIYMASLQNLSVveiqLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTP 74
Cdd:TIGR00711 275 FYLLPLYLQQVLGYTA----LQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTP 344
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
24-207 |
3.95e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 45.33 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAP 103
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 104 AEDRGKVLGRLQSSVSAGSLVGPLIGGVTASiLGFSA---LLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRR 180
Cdd:cd17393 117 RAYGRPIMSSLHAMWSLGGLAGALLGAAAIG-AGVSPgvhLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFL 195
|
170 180
....*....|....*....|....*..
gi 581842029 181 SFQCLLctqqtcrfIIVGVLANFAMYG 207
Cdd:cd17393 196 LPNRLL--------LLLGLLALAAALA 214
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
3-91 |
4.62e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.26 E-value: 4.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 3 LLPIYMASLQNLSVveiqLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALC---TTPLQFVL 79
Cdd:cd17503 200 LLPLYLQNVLGYSA----FESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIIL 275
|
90
....*....|..
gi 581842029 80 VRLLQGLFGGVV 91
Cdd:cd17503 276 PLFIRGLGMGLV 287
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-365 |
6.36e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 6.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 22 WSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASA 100
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 101 EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA---LLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKG 177
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIawrVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 178 iRRSFQCLLCTQQTCRFIIVGVL----ANFAMYGMLTALSPLASSVNHtaIDDRSVIGFLqSAFWTASILSAPLWGRFND 253
Cdd:cd17371 195 -DRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERG--LSFEGSAGYL-VVTILGGFLGYLAGGFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 254 KSYVKSVYIFATIACGCS--AILQGLATNIEFLMAARILqGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSmlvVGQI 331
Cdd:cd17371 271 RIGRRNNFALFALGSAISilLYFFLPLSPTLILILGFPL-GFFASGPFSGMGAYLTELFPTAVRATAQGFCYN---VGRI 346
|
330 340 350
....*....|....*....|....*....|....
gi 581842029 332 IGSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17371 347 IGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGL 380
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
36-155 |
6.68e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 44.57 E-value: 6.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 36 IASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQ 115
Cdd:cd17389 79 LSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIG 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 581842029 116 SSVSAGSLVGPLIGGVTASILGFS-----------ALLMSIAVITFIVCIF 155
Cdd:cd17389 159 VAFSLGFIIGPMIGAYFASFTRSLgevffsmpalfALVLALADLLFIFFFL 209
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
31-365 |
6.77e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.52 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 31 AVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLlQGLFGGVVDASSAFASAEAPAEDRGKV 110
Cdd:cd17331 45 SVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-PSVFMHAMQAAQMVVTDLTDPGERAAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 111 LGRLQSSVSAGSLVGPLIGGVTASILG-----FSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCL 185
Cdd:cd17331 124 LGRLGLSYGIGMVVGSFLGGLLTKKFGeqaaaLVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 186 LCTQQTCRFIIVGVLANFAMyGMLTALSPLAssvnhtAID----DRSVIGFLQSAFWTASILS-----APLWGRFNDKSY 256
Cdd:cd17331 204 LRLPGVAFLLLVKLLSGLPI-GMFQSMFSLV------AMDffglTPEENGYLMSYAGVLGMVVqgllvGPLTKRFGERSL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 257 VK-SVYIFA---TIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVmfvvvnacHQQLKGTFVGTTNSMLVVGQII 332
Cdd:cd17331 277 LKlSVALLAigyLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV--------PPEDTGTALGLSHALFSLVRTV 348
|
330 340 350
....*....|....*....|....*....|...
gi 581842029 333 GSLSGAAITSYTTPATTFIVMGVVFAVSSLFLI 365
Cdd:cd17331 349 SPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
1-364 |
9.79e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 9.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASlQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17477 16 LPLLSLRLER-EGVS----TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLFGGVVDASS-AFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVtASILGFSALLMSiAVITFIVCIFGALK 159
Cdd:cd17477 91 RFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIA-AVLLLLALVPLLLT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 160 LIETTHMPKSQTPNINKGIRRSfqcllctqqtcRFIIVGVLANFAMYGMLTALSPL-ASSVNHTAiddrSVIGFLQSAFW 238
Cdd:cd17477 169 RRAAPEIEEAESISLRRLLRIA-----------PLALLGAFVAGFLEGAFYSLLPLyGLRLGLSV----AQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 239 TASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGltysALIQSVMFVVVNACHQQLKGT 317
Cdd:cd17477 234 LGGLLLQWPLGWLADRfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG----GAAGPLYTLALALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 581842029 318 FVGTTNSMLV----VGQIIGSLSGAAITSYTTPATTFIVMGVVFAVSSLFL 364
Cdd:cd17477 310 ELVAANAALLllygLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-363 |
1.11e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 35 MIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRL 114
Cdd:cd17333 45 LIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 115 QSSVSAGSLVGPLIGGV-TASILGFSALLMSIAVITFIVCIFGALklietTHMPKSQTPNINKGIRRSFQCLLCTQQTCR 193
Cdd:cd17333 125 HGFFGLGALIGPLIATSlLTSELSWSWAYLIIGLIYLLLAILILL-----TLFPELPSARNPQQSVGAFSASASRLLRNP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 194 FIIVGVLANFAMYGMLTALSPLASSVNHTAID-DRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKsVYIFATIACGCSA 272
Cdd:cd17333 200 SIILGALALFLYVGAETAFSSWVPSYLVEKKHvSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH-TLLVLSGSGALLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 273 ILQGL-ATNIEFLMAARILQGLTYSAL---IQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPAt 348
Cdd:cd17333 279 LLILLlAPTLVVGLVATALLGLFMAALfptILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAML- 357
|
330
....*....|....*
gi 581842029 349 TFIVMGVVFAVSSLF 363
Cdd:cd17333 358 LITILYAIIFVLALL 372
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
24-274 |
2.04e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.00 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAE-A 102
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRwF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 103 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFI--VCIFGALKLIETTHMPKSQTPNINKGIRR 180
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILaaVLFWLFYREPPAASAATESASTLLRSLKE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 181 sfqcLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIddrSVIGFLQSAFWTASILSAPLWGRFNDKSYV--- 257
Cdd:cd17475 194 ----VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSV---VAAGALLAVAQLGGALGRIGLGRVSDRVFGgrr 266
|
250
....*....|....*..
gi 581842029 258 KSVYIFATIACGCSAIL 274
Cdd:cd17475 267 RPVLVITAAIAAAALLV 283
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
31-369 |
3.40e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 31 AVTTMIasPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGK 109
Cdd:cd17503 43 ALAIMI--PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEkRGA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 110 VLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALklietthmpksqtpnINKGIRRSFQCLLctq 189
Cdd:cd17503 121 AMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL---------------LDLRLFKDRNFTL--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 190 qtcrFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACG 269
Cdd:cd17503 183 ----GLLLSFLLGLGLFGAMFLLPLYLQNVLGY---SAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 270 CSAILQGLA---TNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIG-SLSGAAITSYTT 345
Cdd:cd17503 256 LGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLTNRTQ 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 581842029 346 ---------------PATTFIVMGVVFAVSSLFLICSTI 369
Cdd:cd17503 336 fhhsrlsellaqqvqKQALIIAFNDAFLVSAILLLVGLL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-155 |
5.68e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 34 TMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLG 112
Cdd:TIGR00895 65 MAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVG 144
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 581842029 113 RLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIF 155
Cdd:TIGR00895 145 LMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
226-365 |
6.83e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 6.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 226 DRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFV 305
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNAL 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 581842029 306 VVNACHQQLKGTFVGTtnsmLVVGQIIGSLSGAAITSYTTPA----TTFIVMGVVFAVSSLFLI 365
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGL----MFCGYPIGAAVGGFLAGWLIPVfgwrSLFYVGGIAPLLLLLLLM 189
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
1-87 |
8.03e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.03 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQnLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVcLFLMALCTTPLQFVLV 80
Cdd:cd17335 17 LPFLSVYLKQLG-LSPTQI----GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAV-LFFLSLFFVAQIFWLL 90
|
....*..
gi 581842029 81 RLLQGLF 87
Cdd:cd17335 91 LLLVILG 97
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
40-298 |
9.01e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 9.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 40 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTT--------PLQFVLVRLLQGL-----FGGVVdassAFASAEAPAED 106
Cdd:cd17369 63 VFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTyaqigilaPILLVLLRLLQGLalggeWGGAV----LMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 107 RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAL---------LMSIAVItfIVCIFGALKLIETTHMPKSQtpniNKG 177
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAFlswgwripfLLSAVLV--AVGLYIRLRLEETPVFRRAK----EAG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 178 IRRSFQCLLCTQQTCRFIIVGVLANFAMYG---MLTALSpLASSVNHTAIDDRSV--IGFLQSAFWTASIlsaPLWGRFN 252
Cdd:cd17369 213 QVVRAPLVEVLRRHWRALLLAIGLRLAENVlfyLFTTFA-LSYATQTLGVDRSTVllAVLIASVVAAITI---PLFGWLS 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 581842029 253 DKSYVKSVYIFATIACGCSAIL--------QGLATNIEFLMAARILQGLTYSAL 298
Cdd:cd17369 289 DRVGRRPVYLAGALLAALFAFPffwlldtgSTWLIVLAAVVVLGVLHGMMYGPQ 342
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
210-365 |
1.50e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 210 TALSPLASSVNHTAiddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARI 289
Cdd:cd17503 17 VALPTIMGDLGASL----DTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 581842029 290 LQGLTYSALI---QSVMFVVVNACHQQLKGTFVGTTnsmLVVGQIIGSLSGAAITSYTTPATTFIVMgVVFAVSSLFLI 365
Cdd:cd17503 93 LQGFGGGVLIplaQTILLRIYPPEKRGAAMGLVGLV---ILLAPAIGPTLGGWLTDNLSWRWIFYIN-LPIGILALLLA 167
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
1-364 |
1.58e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLV 80
Cdd:cd17472 16 LPVLSVYAKSLPGAT----PTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 81 RLLQGLfGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL 160
Cdd:cd17472 92 RALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 161 IettHMPKSqtPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDdrsVIGFLQSAFWTA 240
Cdd:cd17472 171 P---DPPKI--VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQ---LWKVYLPAILIG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 241 SILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAArilqGLT--------YSALIQSVMFVVVNAchq 312
Cdd:cd17472 243 FILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLII----GLIiffigfnlLEALLPSLVSKIAPK--- 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 581842029 313 QLKGTFVGTTNSMLVVGQIIGSLSGAAITSYTTPATTF---IVMGVVFAVSSLFL 364
Cdd:cd17472 316 EYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFltiLILALLWLLVSFLL 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
3-158 |
2.05e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 3 LLPIYMASLQNLSVVEIQLWSGIAiaapAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTT---PLQFVL 79
Cdd:cd17316 199 FLPTYLQTVLGLSPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSgspTLLLLL 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 581842029 80 VRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGAL 158
Cdd:cd17316 275 LFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
40-211 |
2.30e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.90 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 40 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRgkvLGRLQSSV- 118
Cdd:PRK11102 45 FYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEE---FSRMMSFVt 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 119 ---SAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIrRSFQCLLCTQQTCRFI 195
Cdd:PRK11102 122 lvmTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPKERRQPFHLRTTI-RNFASLFRHKRVLGYM 200
|
170
....*....|....*.
gi 581842029 196 IVGVLANFAMYGMLTA 211
Cdd:PRK11102 201 LASGFSFAGMFSFLTA 216
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
1-90 |
2.39e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.54 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 1 MPLLPIYMASLQnLSVVEIQLWSGIAIAapavTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTP-LQFVL 79
Cdd:pfam12832 19 LPYWGLYLRSIG-LNPSEIGLITAILPL----TRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFIPIsLTFWW 93
|
90
....*....|.
gi 581842029 80 VRLLQGLFGGV 90
Cdd:pfam12832 94 LALLVVLFSFF 104
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-163 |
2.40e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.56 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGV-VDASSAFASAEA 102
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWF 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 581842029 103 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIET 163
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS 181
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
40-368 |
3.82e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 38.90 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 40 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDR-GKVLGRLQSSV 118
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEElSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 119 SAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIETthMPKSQTPNINKGIrRSFQCLLCTQQTCRFIIVG 198
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPET--LPYEARIQISTYF-ETFLLLLKSKMFWGYALIY 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 199 VLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSafwTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI----- 273
Cdd:TIGR00710 216 GASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNI---IAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVlleit 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 274 -LQGLATNIEFLMAArILQGLTYSALIQSVMFVVVNAChqqlkGTFVGTTNSM-----LVVGQIIGSLSGAAitSYTTPA 347
Cdd:TIGR00710 293 aILGLGSWAMIIGPM-MFVGIGNSMISSIAMAYALEDF-----PHVAGTASALfgtlrLVLGAIVGYLVSLI--HGNTAW 364
|
330 340
....*....|....*....|.
gi 581842029 348 TTFIVMGVVFAVSSLFLICST 368
Cdd:TIGR00710 365 PMSLSCLVLAVVSVLAFYYLS 385
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
24-251 |
6.29e-03 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 38.46 E-value: 6.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 24 GIAIAAPAVTTMIASPIWGKLGDKISRKWM-----VLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFA 98
Cdd:TIGR00900 37 SLAALAGMLPYVVLSPIAGALADRYDRKKVmigadLIRAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAM 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 99 SAEAPAEDR-GKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAlLMSIAVITFivciFGALKLIETTHMPKSQ------- 170
Cdd:TIGR00900 117 LPDLVPEEQlTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKW-AIWVDAVGF----AISALLIVSVRIPELAaseiqal 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 171 TPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASS--VNHTAIDdrsvIGFLQSAFWTASILSAPLW 248
Cdd:TIGR00900 192 SNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAIVALFPYVQSkyLGRGSTH----YGWVLAAFGLGALLGALLL 267
|
...
gi 581842029 249 GRF 251
Cdd:TIGR00900 268 GLL 270
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-155 |
7.51e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842029 40 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASA-EAPAEDRGKVLGRLQSSV 118
Cdd:cd17323 53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIAdLFTPEERGKAMGVYSLGP 132
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 581842029 119 SAGSLVGPLIGGVTASILGFSA---LLMSIAVITFIVCIF 155
Cdd:cd17323 133 LLGPALGPIIGGFITQSLGWRWifwFLAIISGFCLILIFL 172
|
|
| |
