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Conserved domains on  [gi|581842024|gb|EVS44192|]
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iron compound ABC transporter, permease SirB [Staphylococcus aureus M1365]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 23-328 1.64e-90

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 272.71  E-value: 1.64e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  23 SLMIGNTLVSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFV 102
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 103 IFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGmFRQTLFSPHRVILAGAAIAMLFTAFTQGIL-IMNETDLQGLLFWL 181
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 182 SGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGL 261
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 262 IVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 23-328 1.64e-90

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 272.71  E-value: 1.64e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  23 SLMIGNTLVSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFV 102
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 103 IFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGmFRQTLFSPHRVILAGAAIAMLFTAFTQGIL-IMNETDLQGLLFWL 181
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 182 SGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGL 261
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 262 IVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 16-326 2.27e-76

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 236.65  E-value: 2.27e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   16 LAIVAILSLMIGNTLVSPGTVIQALFNFDSeNDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVN 95
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   96 AGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRqTLFSPHRVILAGAAIAMLFTAFTQGILI-MNETDL 174
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGR-GGASPLRLILAGIAVSALLSALTSLLLLlLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  175 QGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAG 254
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581842024  255 SIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKK 326
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
14-328 2.40e-55

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 183.37  E-value: 2.40e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  14 LCLAIVAILSLMIGNTLVSPGTVIQALFNFDSENDLhDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFG 93
Cdd:PRK10441  18 LLLIIATALSLLIGAKSLPASVVLEALSGTCQSADC-TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  94 VNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRQTLFSPHRVILAGAAIAMLFTAFTQGILIMNETD 173
Cdd:PRK10441  97 VNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 174 LQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVA 253
Cdd:PRK10441 177 YDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVV 256

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 581842024 254 GSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIkPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:PRK10441 257 GPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKT 330
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 61-324 4.35e-43

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 149.24  E-value: 4.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  61 TIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRQ 140
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 141 tlFSPHRVILAGAAIAMLFTAFTQGILIMNETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTS 220
Cdd:cd06550   81 --LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 221 DDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARII 300
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 581842024 301 IkPLELPIGVVTAVIGAIVLIYIM 324
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 23-328 1.64e-90

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 272.71  E-value: 1.64e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  23 SLMIGNTLVSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFV 102
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 103 IFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGmFRQTLFSPHRVILAGAAIAMLFTAFTQGIL-IMNETDLQGLLFWL 181
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLlLADPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 182 SGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGL 261
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 262 IVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 16-326 2.27e-76

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 236.65  E-value: 2.27e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   16 LAIVAILSLMIGNTLVSPGTVIQALFNFDSeNDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVN 95
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   96 AGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRqTLFSPHRVILAGAAIAMLFTAFTQGILI-MNETDL 174
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGR-GGASPLRLILAGIAVSALLSALTSLLLLlLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  175 QGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAG 254
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581842024  255 SIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKK 326
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 1-330 5.65e-57

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 187.64  E-value: 5.65e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   1 MLLKPKYQIVIAGLCLAIVA--ILSLMIGNTLVSPGTVIQALFNFDSENDlHDVVTGARASRTIIALLTGAALAVSGLLM 78
Cdd:COG4779   16 LRLRRRALLVTLVLLLLLLAlaVLALTLGDYPLSPGDVLRALLGEGDPGA-SFVVLELRLPRALAALLVGAALGLSGAIF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  79 QALTRNPIASPGLFGVNAGAVFFVIFSITFIQIQSFkMIVVIAFLGAIVVTILVVALGMFRQtlFSPHRVILAGAAIAML 158
Cdd:COG4779   95 QSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGL-AVALGALAGGLATALLVYLLAWRGG--VSGYRLILVGIGVSAM 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 159 FTAFTQGILIM-NETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWM 237
Cdd:COG4779  172 LTAVNSYLLTRaDLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 238 IIMLISMLAGISVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPfTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGA 317
Cdd:COG4779  252 LLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGG 330

                        330
                 ....*....|...
gi 581842024 318 IVLIYIMKKGRQR 330
Cdd:COG4779  331 PYLLWLLIRENRR 343
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
14-328 2.40e-55

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 183.37  E-value: 2.40e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  14 LCLAIVAILSLMIGNTLVSPGTVIQALFNFDSENDLhDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFG 93
Cdd:PRK10441  18 LLLIIATALSLLIGAKSLPASVVLEALSGTCQSADC-TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  94 VNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRQTLFSPHRVILAGAAIAMLFTAFTQGILIMNETD 173
Cdd:PRK10441  97 VNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 174 LQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVA 253
Cdd:PRK10441 177 YDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVV 256

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 581842024 254 GSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIkPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:PRK10441 257 GPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKT 330
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
9-328 1.60e-52

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 183.12  E-value: 1.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   9 IVIAGLCLAIVAILSLMIGNTLVSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIAS 88
Cdd:PRK10577  14 ALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  89 PGLFGVNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRQtlFSPHRVILAGAAIAMLFTAFTQGILI 168
Cdd:PRK10577  94 PTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKR--LSPLRLVLAGMVVSLYLGALTTLLLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 169 MNETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGI 248
Cdd:PRK10577 172 FNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 249 SVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARII--IKPLELPIGVVTAVIGAIVLIYIMKK 326
Cdd:PRK10577 252 VVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLPR 331


                 ..
gi 581842024 327 GR 328
Cdd:PRK10577 332 LR 333
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
9-330 1.07e-50

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 178.11  E-value: 1.07e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   9 IVIAGLCLAIVAILSLMIGNTlvspgtviQALFNFDSENDLHDVVTgARASRTIIALLTGAALAVSGLLMQALTRNPIAS 88
Cdd:PRK10577 358 LLALGLLLLLALVVALSFGRD--------AHGWNWLSGQLLDALLP-LRLPRLLAALLAGAMLAVAGTLLQRLTRNPLAS 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  89 PGLFGVNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGmfRQTLFSPHRVILAGAAIAMLFTAFTQGILI 168
Cdd:PRK10577 429 PEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLA 506

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 169 MNETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGI 248
Cdd:PRK10577 507 SGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAA 586

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 249 SVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:PRK10577 587 ATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666


                 ..
gi 581842024 329 QR 330
Cdd:PRK10577 667 RR 668
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 6-329 5.57e-48

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 163.87  E-value: 5.57e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   6 KYQIVIAGLCLAIVAILSLMIGNTLVSPGTVIQALFNFdsendlhdVVTGARASRTIIALLTGAALAVSGLLMQALTRNP 85
Cdd:COG4139   12 RRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQL--------FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  86 IASPGLFGVNAGAVFFVIFSITFIQIQSFKMIVVI-AFLGAIVVTILVVALGMFRqtlFSPHRVILAGAAIAMLFTAF-T 163
Cdd:COG4139   84 LAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLaAIAGALLVTLLLLAFARRR---LSNARLLLIGVALGIICSAImT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 164 QGILIMNETDLQGLLFWLSGSVSlrNI-WDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLI 242
Cdd:COG4139  161 WAVYFSSSLDLRQLMYWMMGSFG--GVdWRQLWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLAT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 243 SMLAGISVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIY 322
Cdd:COG4139  239 GLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIW 318


                 ....*..
gi 581842024 323 IMKKGRQ 329
Cdd:COG4139  319 LLLRRRK 325
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
31-326 7.41e-47

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 161.02  E-value: 7.41e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  31 VSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFVIFSITFIQ 110
Cdd:PRK11228  25 ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 111 IQ-SFKMIVVIAFLGAIVVTILVVALGMFRQTLFSPHRVILAGAAIAMLFTAFTQGILIMNETDLQGLLFWLSGSVSLRN 189
Cdd:PRK11228 105 TPfAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHAR 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 190 IWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGLIVPNISKR 269
Cdd:PRK11228 185 WQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARF 264

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 270 LLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKK 326
Cdd:PRK11228 265 WIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 14-328 5.29e-44

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 153.57  E-value: 5.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  14 LCLAIVAILSLMIGNTLVSPGTViqalfnFDSENDLhdVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFG 93
Cdd:PRK03784  23 VLLLLALLLSLCAGEQWISPGDW------LSPRGEL--FVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  94 VNAGA-VFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVvaLGMFRQTLFSPHRVILAGAAIAMLFTAF-TQGILIMNE 171
Cdd:PRK03784  95 VSNGAgVALVAAVLLGQGLLPPWALSLCAIAGALLITLIL--LRFARRHRLSTSRLLLAGVALGIICSALmTWAVYFSTS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 172 TDLQGLLFWLSGSVSLRNiWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVA 251
Cdd:PRK03784 173 LDLRQLMYWMMGGFGGVD-WRQSWLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVA 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 252 VAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:PRK03784 252 LAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
9-328 6.72e-44

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 152.89  E-value: 6.72e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024   9 IVIAGLCLAIVAILSLMIGnTLVSPGTVIQALFNFDSENdlHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIAS 88
Cdd:PRK09777   6 VIFITLALAGCALLSLRMG-VIPLPWRALLTDWQAGDEH--YYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLAS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  89 PGLFGVNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRqtlfSPHRVILAGAAIAMLFTAFTQGILI 168
Cdd:PRK09777  83 PDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTH----QPMKLALTGVALSALWASLTDYLML 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 169 MNETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGI 248
Cdd:PRK09777 159 SRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTAT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 249 SVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIMKKGR 328
Cdd:PRK09777 239 GVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 61-324 4.35e-43

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 149.24  E-value: 4.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  61 TIIALLTGAALAVSGLLMQALTRNPIASPGLFGVNAGAVFFVIFSITFIQIQSFKMIVVIAFLGAIVVTILVVALGMFRQ 140
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 141 tlFSPHRVILAGAAIAMLFTAFTQGILIMNETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTS 220
Cdd:cd06550   81 --LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 221 DDIATGLGQNIKLIKWMIIMLISMLAGISVAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARII 300
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 581842024 301 IkPLELPIGVVTAVIGAIVLIYIM 324
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYLL 261
btuC PRK09535
cobalamin ABC transporter permease BtuC;
10-326 7.22e-34

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 127.56  E-value: 7.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  10 VIAGLCLAIVAILSLMIGNTLVSPGTVIQALFNFDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASP 89
Cdd:PRK09535  48 VPVGVAVTTHGVPVLSVGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADP 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  90 GLFGVNAGAVFFVIFSITFIQIQSFKmIVVIAFLGAIVVTILVVALGMfRQTLFSPHRVILAGAAIAMLFTAFTQGILIM 169
Cdd:PRK09535 128 SIIGVSSGAAVGAVAAIVLPLAVPFG-LQAAAFAGALVAAFGVYAIAT-ENGRTPVATLLLAGVAVQTFLGAVISYLLLH 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 170 NETDLQGLLFWLSGSVSLRNIWDIPWIIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGIS 249
Cdd:PRK09535 206 SGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAA 285

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 581842024 250 VAVAGSIVFVGLIVPNISKRLLPPNYKYLIPFTALAGAILMIISDIVARiiIKPLELPIGVVTAVIGAIVLIYIMKK 326
Cdd:PRK09535 286 VAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
15-324 2.11e-27

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 109.41  E-value: 2.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  15 CLAIvAILSLMIGNTLVSPGTVIQALFNfDSENDLHDVVTGARASRTIIALLTGAALAVSGLLMQALTRNPIASPGLFGV 94
Cdd:PRK10440  19 CVAA-GLWGLRSGAVTLETSQVFAALMG-DAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024  95 NAGAVFFVIFSITFIQiQSFKMIVVIAFLGAIvVTILVVALGMFRQTLFSpHRVILAGAAIAMLFTAFTQGILIMN--ET 172
Cdd:PRK10440  97 NTGAWSGVLVAMVLFG-QDLTAIALAAMAGGI-VTSLLVWLLAWRNGIDT-FRLIIIGIGVRAMLVAFNTWLLLKAslET 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842024 173 DLQGLLfWLSGSVSLRNiWDIPW-IIPLVLILILIAFSMAAHINILMTSDDIATGLGQNIKLIKWMIIMLISMLAGISVA 251
Cdd:PRK10440 174 ALTAGL-WNAGSLNGLT-WAKTSpSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATA 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 581842024 252 VAGSIVFVGLIVPNISKRLLPPNYKYLIPfTALAGAILMIISDIVARIIIKPLELPIGVVTAVIGAIVLIYIM 324
Cdd:PRK10440 252 LAGPISFIALVAPHIARRLSGTARWGLTQ-AALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLL 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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