B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  227 KFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDA 277
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  111 NFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNES 161
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 581842021 426 VHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVV 469
Cdd:cd00118    2 TYTVKPGDTLWSIAKKYGVTVEELAAANPLINPDCIYPGQKLKI 45

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  227 KFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDA 277
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  111 NFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNES 161
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 581842021 426 VHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVV 469
Cdd:cd00118    2 TYTVKPGDTLWSIAKKYGVTVEELAAANPLINPDCIYPGQKLKI 45

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 581842021  427 HVVKPGDTVNDIAKANGTTADKIAADNKLADKNmIKPGQELVV 469
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGLSSPN-LYVGQKLKI 42

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.

                          10        20
                  ....*....|....*....|....*
gi 581842021   14 KKKNIYSIRKLGVGIASVTLGTLLI 38
Cdd:pfam04650   1 EKKQRYSIRKLSVGVASVLIGTLLF 25

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842021  11 INLKKKNIYSIRKLGVGIASVTLGTLLISGGVTpaanaAQHDEAQQNAFYQVLNMPNlnadqrngfiQSLKDDPSQsanv 90
Cdd:NF033609   1 MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLS-----SKEADASENSVTQSDSASN----------ESKSNDSSS---- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581842021  91 LGEAQKLNDSQAPKADAQQNNFNKDQQSAfyeilnmpnLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQA--PKADN 168
Cdd:NF033609  62 VSAAPKTDDTNVSDTKTSSNTNNGETSVA---------QNPAQQETTQSASTNATTEETPVTGEATTTATNQAntPATTQ 132

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 581842021 169 NFNKEQQNAFYEILNMPNLNEEQRNGFIQSLK-----DDPSQSANLLSEAKKLNESQAPKADNKFNKEQQN 234
Cdd:NF033609 133 SSNTNAEELVNQTSNETTSNDTNTVSSVNSPQnstnaENVSTTQDTSTEATPSNNESAPQSTDASNKDVVN 203

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  227 KFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDA 277
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

B domain; This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 581842021  111 NFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNES 161
Cdd:pfam02216   1 DYNKAQQNAFYQVLHLPNLNEEQRNGFIQSLKDDPSQSQNVLGEAKKLNDS 51

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 581842021 426 VHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVV 469
Cdd:cd00118    2 TYTVKPGDTLWSIAKKYGVTVEELAAANPLINPDCIYPGQKLKI 45

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 581842021  427 HVVKPGDTVNDIAKANGTTADKIAADNKLADKNmIKPGQELVV 469
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGLSSPN-LYVGQKLKI 42

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.

                          10        20
                  ....*....|....*....|....*
gi 581842021   14 KKKNIYSIRKLGVGIASVTLGTLLI 38
Cdd:pfam04650   1 EKKQRYSIRKLSVGVASVLIGTLLF 25

Cytoplasmic potassium-binding protein Kbp/XkdP/YgaU, contains LysM domain [Inorganic ion transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 581842021 420 KEDGNGVHVVKPGDTVNDIAKA---NGTTADKIAADNK--LADKNMIKPGQELVV 469
Cdd:COG1652  105 APDAPKTYTVKPGDTLWGIAKRfygDPARWPEIAEANRdqIKNPDLIYPGQVLRI 159