|
Name |
Accession |
Description |
Interval |
E-value |
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
11-1215 |
0e+00 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 1424.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 11 IWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRdGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPAN 90
Cdd:TIGR02785 1 QWTDEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKITR-GVDVDRLLVVTFTNAAAREMKERIAEALEKELVQEPNS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 91 AHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDP-AFIELTEQLSS 169
Cdd:TIGR02785 80 KHLRRQLALLNTANISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEEYYKEDKeAFFELVDNFSG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 170 DRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEA----QQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGV 245
Cdd:TIGR02785 160 DRSDDGLRDLILQLYDFSRSTPNPEKWLNNLAEAYEVKEkftiESLKLQQQIKELLKNELEGLQEKLQRALELFMAEDGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 246 DKHLAVIEDERRLMGRVLEGGFIDIPYLTDHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKNDYFSRE 325
Cdd:TIGR02785 240 APRLENFQLDLQNIDELIQESLAQADWNELRKAVAAFKFKNLKAAKGDEEDADLLEEADKLREEAKKQLEKLKTDYFTRS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 326 ADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQD 405
Cdd:TIGR02785 320 EEDHLRIMQEMKPVVKTLVQLVKDFIERFGAEKREKNILDFSDLEHYALQILTNENESPSEAAEFYREKFHEVLVDEYQD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 406 TNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYI 485
Cdd:TIGR02785 400 TNLVQESILQLVKRGPEEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEGEEHGKRIDLAENFRSRAEVLDTTNFL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 486 FKHMMDEQVGEVKYDEAAQLYYGA-------PYDESDHPVNLKVLVEADQEHSD-----LTGSEQEAHFIVEQVKDIL-E 552
Cdd:TIGR02785 480 FKQLMDEEVGEIDYDEEAQLKFGAakypenpDNKTEELLYEKLLIEEAEEEEIDeeaeiLDKAQQEATMVAERIKALIkE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 553 HQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGL 632
Cdd:TIGR02785 560 GFKVYDKKTGTYRPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLVAV 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 633 MRSVIYQFKEDELAQIRILSpNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVI 712
Cdd:TIGR02785 640 LRSPIVGFDENELALIRLEN-KDSSYYEAVKDYVKAGLIEDELYEKLNTFLDSLQKWREFARTHSVSELIWKIYNDTGYY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 713 QYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFV 792
Cdd:TIGR02785 719 DYVGGLPGGKQRQANLYALYERARQYESTSFKGLFQFIRFIERMQERQKDLASAVAVGEAENAVRLMTIHKSKGLEFPVV 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 793 IYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRV 872
Cdd:TIGR02785 799 FVLGMGKQFNKQDLNSSYLLDRQLGLGIKYIDPQERLSYPSLPKVAIKQKMKRELLSEEMRVLYVALTRAKEKLILVGSV 878
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 873 KNDKSLLE--LEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQVEDSSRpNVNISIIYFEDVS 950
Cdd:TIGR02785 879 KDEKKELKkwLAALAQSDWLLPENDRLQARNYLDWIGPALARHRDIKLLGDDAGVSIHDELTKDPA-NFAVEVIDSYDLL 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 951 TETILDNNEYRSVNQLETMQN----GNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRI 1026
Cdd:TIGR02785 958 AEELEERMDEKSEQLEALADKnqstGDKEFREKLREQLSYDYPHQAATETPAKQSVSEIKRIFEDEDEGSERAPVKQSRG 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1027 GFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKeRISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELY 1106
Cdd:TIGR02785 1038 KSISLERPKFLTKTKGLTAAEIGTATHLVMQHIDLSK-DPSEEELQQTIDRLVKKELLTEEQAEKIDIDKIVAFFDTPLG 1116
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1107 SIIAEAEQVYRELPFVVN----QALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNrrrGMTDEEIGTQLKN 1182
Cdd:TIGR02785 1117 KQILKAKEVLRREPFFSMlisaEIYFDAHDEADEEDILVQGIIDGYYETEDGLYLFDYKTDHVE---GHGFEGAINQLKE 1193
|
1210 1220 1230
....*....|....*....|....*....|...
gi 581790339 1183 KYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTL 1215
Cdd:TIGR02785 1194 RYRGQLQLYEKALEEIYKKKVKGKYLYLLDGDH 1226
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
10-1217 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 630.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 10 VIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADP- 88
Cdd:COG1074 4 PPWTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLEDp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 89 -------ANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENiLLLEQTIDEVIEQHYDILDP-AF 160
Cdd:COG1074 84 dleelarARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEA-LLLEEAVDDLLREAYAPLDAlAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 161 IELTEQLSsdRSDDQFRMIIKQLYFFSVANpnptNWLDQLvtpyeeeaqqAQLIQLLTDLSKVFITAAydalnkaydlfs 240
Cdd:COG1074 163 ARLLDAFG--RDDDSLEELLLALYKLRSRP----DWLEEL----------AELDEALEALREALLKAK------------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 241 mmdgvdkhlaviederrlmgrvleggfidipyltdhefgarlpnvtakikeanemmvDALEDAKLQYKkykslidkvknd 320
Cdd:COG1074 215 ---------------------------------------------------------EALAALREALA------------ 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 321 yfsreaddlkadmQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDgsPSEIAESYRQHFQEILV 400
Cdd:COG1074 226 -------------AAAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDED--APWVAERLRERYRHILV 290
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 401 DEYQDTNRVQEKILSCIKTGDEH-NGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFtiDGDGTGRRIDLSQNFRSRKEVL 479
Cdd:COG1074 291 DEFQDTSPLQWEILRRLAGEALAdGRTLFLVGDPKQSIYRFRGADPELFLEARRAL--EGRVDGERLTLTTNFRSTPEVV 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 480 STTNYIFKHMMDEQVGEVKYDEAAQLYYGApydesDHPVNLKVLVEADQEHSDLTgsEQEAHFIVEQVKDILEHQKvydM 559
Cdd:COG1074 369 DAVNALFAQLMGAGFGEIPYEPVEALRPGA-----YPAVELWPLEPDDVSEEDAR--EREARAVAARIRRLLAEGT---T 438
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 560 KTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQ 639
Cdd:COG1074 439 VEGGGRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFG 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 640 FKEDELAQIRILSPNDDyFYQSIVNYindeaadailvDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLI 719
Cdd:COG1074 519 LSDEDLAALAADRKGES-LWEALRAY-----------ERLARALERLRALRELARRLGLAELLERLLEETGLLERLLALP 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 720 GGRGRRAN---LYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDfGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYsg 796
Cdd:COG1074 587 GGERRLANllhLDELLQLALEYEQTGGPGLAGFLRWLERLIEDGGD-EEKRRLESDADAVRIMTIHKSKGLEFPVVFL-- 663
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 797 lskdfnkrdlkqpvilnqqfglgmdyfdvdkemafpslasVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDK 876
Cdd:COG1074 664 ----------------------------------------PALRERARAEELAEELRLLYVALTRARDRLVLSGAVKKKD 703
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 877 Slleleqlsisgehiavnerltspnpfhliysilskhqsasipddlkfekdiaqvedssrpnvnisiiyfedvstetild 956
Cdd:COG1074 704 A------------------------------------------------------------------------------- 704
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 957 nneyrsvnqletmqngnedvkaqikhqldyqypyvndtkkpskqsvselkrqyeteESGTSYERvrqyrigfstyerpkf 1036
Cdd:COG1074 705 --------------------------------------------------------EKESSWLA---------------- 712
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1037 lseqgkrkanEIGTLMHTVMQHLPFKKERisevELHQYIDGLIDKHIIEADAKKDIRmDEIMTFINSELYSIIAEAEQVY 1116
Cdd:COG1074 713 ----------RRGTLVHRLLEHLDFSAPA----ELRAALARLLARGGLDEEEAEALA-EALLAFLATPLLAELFAAAEVL 777
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1117 RELPFVvnqalvdqLPQGDEDVS-IIQGMIDLIFVKDGVHYFVDYKTDafnrRRGMTDEEigtQLKNKYKIQMKYYQNTL 1195
Cdd:COG1074 778 REVPFL--------LPDLYRGLGgLLKGRIDLVFEDDGRVYIVDYKTN----RLGPDDEE---YLPERYRLQLALYALAL 842
|
1210 1220
....*....|....*....|...
gi 581790339 1196 QTIL-NKEVKGYLYFFKFGTLQL 1217
Cdd:COG1074 843 ERLLpGRPVRAGLYFTDRGRLVE 865
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
12-455 |
7.91e-48 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 172.04 E-value: 7.91e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 12 WTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVdqriqeasiadpaNA 91
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERI-------------LK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 92 HLKNQRIKihQAQISTLHSFCLKLIQQHYDVLNIDPNFRTsseaenillleqtidevieqhydildpafielteqlssdr 171
Cdd:pfam00580 68 LLGKAELS--ELNISTFHSFCLRILRKYANRIGLLPNFSI---------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 172 sddqfrmiikqlyffsvanpnptnwldqlvtpYEEEAQQAQLIQLLTDLSKvfitaaydalnkaydlfsmmdgvdkhlav 251
Cdd:pfam00580 106 --------------------------------LDELDQLALLKELLEKDRL----------------------------- 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 252 iederrlmgrvleggfidipyltdhefgarlpnvtakikeanemmvdALEDAKLQYKKYKSLIDKVKNDYFSREaddlka 331
Cdd:pfam00580 125 -----------------------------------------------NLDPKLLRKLELKELISKAKNRLLSPE------ 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 332 dmQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEdgspSEIAESYRQHFQEILVDEYQDTNRVQE 411
Cdd:pfam00580 152 --ELQQGAADPRDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSD----PELLEAYRERFKYILVDEFQDTNPIQY 225
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 581790339 412 KILSCIKTGdehNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRF 455
Cdd:pfam00580 226 RLLKLLAGG---HENLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
14-868 |
7.19e-35 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 143.47 E-value: 7.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 14 DAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIqeasiadpanahl 93
Cdd:PRK11773 12 DKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLL------------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 94 knqRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRtsseaenillleqtidevieqhydILDpafielteqlssdrSD 173
Cdd:PRK11773 79 ---GTSQGGMWVGTFHGLAHRLLRAHWQDANLPQDFQ------------------------ILD--------------SD 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 174 DQFRMI---IKQLyffsvaNPNPTNWldqlvtPyeeeAQQAQLiqlltdlskvFITAAYDalnkaydlfsmmdgvdkhla 250
Cdd:PRK11773 118 DQLRLLkrlIKAL------NLDEKQW------P----PRQAQW----------YINGQKD-------------------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 251 viederrlmgrvlEGgfidipyltdhefgaRLPNvtaKIKEANemmvDALEDAKLQ-YKKYKSLIDkvkndyfsreaddl 329
Cdd:PRK11773 152 -------------EG---------------LRPQ---HIQSYG----DPVEQTWLKiYQAYQEACD-------------- 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 330 kadmqqlaprvkylarivkdvmsefnrkkRSkNILDFSDYEHFALQILTNedgSPsEIAESYRQHFQEILVDEYQDTNRV 409
Cdd:PRK11773 183 -----------------------------RA-GLVDFAELLLRAHELWLN---KP-HILQHYQERFTHILVDEFQDTNAI 228
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 410 QEKILScIKTGDEhnGNLFMVGDVKQSIYKFRQADpslfIEKYQRFTIDGDGTgRRIDLSQNFRSRKEVLSTTNYIFKHm 489
Cdd:PRK11773 229 QYAWIR-LLAGDT--GKVMIVGDDDQSIYGWRGAQ----VENIQRFLNDFPGA-ETIRLEQNYRSTANILKAANALIAN- 299
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 490 MDEQVG-----EVKYDEAAQLYygAPYDESDhpvnlkvlveadqehsdltgseqEAHFIVEQVKDILEHQkvydmktgsy 564
Cdd:PRK11773 300 NNGRLGkelwtDGGDGEPISLY--CAFNELD-----------------------EARFVVERIKTWQDNG---------- 344
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 565 rsATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDiylVGLMRSV------Iy 638
Cdd:PRK11773 345 --GALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLRLIANRNDD---AAFERVVntptrgI- 418
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 639 qfKEDELAQIRILSPNDDY-FYQSIVNYINDE-----AADAilvdkLKMFLSDIQSYQQYSKDHPVYQLIDkfyndhYVI 712
Cdd:PRK11773 419 --GDRTLDVVRQTARDRQLtLWQACRALLQEKvlagrAASA-----LQRFIELIDALAQETADMPLHEQTD------RVI 485
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 713 QYfSGLIG---------GRGRRANLYGLFNKAIEFENSsfrglyqfirfiDELIERGK----------DFGEENvVGPND 773
Cdd:PRK11773 486 KD-SGLRAmyeqekgekGQARIENLEELVTATRQFSYP------------DEDEDLTPlqaflshaalEAGEGQ-ADAHE 551
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 774 NVVRMMTIHSSKGLEFPFViysglskdfnkrdlkqpvilnqqFGLGMDyfdvdkEMAFPSLASvaykaVAEKELVSEEMR 853
Cdd:PRK11773 552 DAVQLMTLHSAKGLEFPLV-----------------------FIVGME------EGLFPSQMS-----LEEGGRLEEERR 597
|
890
....*....|....*
gi 581790339 854 LVYVALTRAKEQLYL 868
Cdd:PRK11773 598 LAYVGITRAMQKLTL 612
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
365-472 |
7.18e-31 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 120.31 E-value: 7.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 365 DFSDYEHFALQILTNEdgspSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGdehNGNLFMVGDVKQSIYKFRQAD 444
Cdd:cd17932 94 DFDDLLLYALELLEEN----PDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGD---GKNLFVVGDDDQSIYGFRGAD 166
|
90 100
....*....|....*....|....*...
gi 581790339 445 PSLFIEKYQRFtidgdGTGRRIDLSQNF 472
Cdd:cd17932 167 PENILDFEKDF-----PDAKVIKLEENY 189
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
11-1215 |
0e+00 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 1424.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 11 IWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRdGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPAN 90
Cdd:TIGR02785 1 QWTDEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKITR-GVDVDRLLVVTFTNAAAREMKERIAEALEKELVQEPNS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 91 AHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDP-AFIELTEQLSS 169
Cdd:TIGR02785 80 KHLRRQLALLNTANISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEEYYKEDKeAFFELVDNFSG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 170 DRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEA----QQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGV 245
Cdd:TIGR02785 160 DRSDDGLRDLILQLYDFSRSTPNPEKWLNNLAEAYEVKEkftiESLKLQQQIKELLKNELEGLQEKLQRALELFMAEDGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 246 DKHLAVIEDERRLMGRVLEGGFIDIPYLTDHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKNDYFSRE 325
Cdd:TIGR02785 240 APRLENFQLDLQNIDELIQESLAQADWNELRKAVAAFKFKNLKAAKGDEEDADLLEEADKLREEAKKQLEKLKTDYFTRS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 326 ADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQD 405
Cdd:TIGR02785 320 EEDHLRIMQEMKPVVKTLVQLVKDFIERFGAEKREKNILDFSDLEHYALQILTNENESPSEAAEFYREKFHEVLVDEYQD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 406 TNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYI 485
Cdd:TIGR02785 400 TNLVQESILQLVKRGPEEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEGEEHGKRIDLAENFRSRAEVLDTTNFL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 486 FKHMMDEQVGEVKYDEAAQLYYGA-------PYDESDHPVNLKVLVEADQEHSD-----LTGSEQEAHFIVEQVKDIL-E 552
Cdd:TIGR02785 480 FKQLMDEEVGEIDYDEEAQLKFGAakypenpDNKTEELLYEKLLIEEAEEEEIDeeaeiLDKAQQEATMVAERIKALIkE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 553 HQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGL 632
Cdd:TIGR02785 560 GFKVYDKKTGTYRPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLVAV 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 633 MRSVIYQFKEDELAQIRILSpNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVI 712
Cdd:TIGR02785 640 LRSPIVGFDENELALIRLEN-KDSSYYEAVKDYVKAGLIEDELYEKLNTFLDSLQKWREFARTHSVSELIWKIYNDTGYY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 713 QYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFV 792
Cdd:TIGR02785 719 DYVGGLPGGKQRQANLYALYERARQYESTSFKGLFQFIRFIERMQERQKDLASAVAVGEAENAVRLMTIHKSKGLEFPVV 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 793 IYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRV 872
Cdd:TIGR02785 799 FVLGMGKQFNKQDLNSSYLLDRQLGLGIKYIDPQERLSYPSLPKVAIKQKMKRELLSEEMRVLYVALTRAKEKLILVGSV 878
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 873 KNDKSLLE--LEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQVEDSSRpNVNISIIYFEDVS 950
Cdd:TIGR02785 879 KDEKKELKkwLAALAQSDWLLPENDRLQARNYLDWIGPALARHRDIKLLGDDAGVSIHDELTKDPA-NFAVEVIDSYDLL 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 951 TETILDNNEYRSVNQLETMQN----GNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRI 1026
Cdd:TIGR02785 958 AEELEERMDEKSEQLEALADKnqstGDKEFREKLREQLSYDYPHQAATETPAKQSVSEIKRIFEDEDEGSERAPVKQSRG 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1027 GFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKeRISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELY 1106
Cdd:TIGR02785 1038 KSISLERPKFLTKTKGLTAAEIGTATHLVMQHIDLSK-DPSEEELQQTIDRLVKKELLTEEQAEKIDIDKIVAFFDTPLG 1116
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1107 SIIAEAEQVYRELPFVVN----QALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNrrrGMTDEEIGTQLKN 1182
Cdd:TIGR02785 1117 KQILKAKEVLRREPFFSMlisaEIYFDAHDEADEEDILVQGIIDGYYETEDGLYLFDYKTDHVE---GHGFEGAINQLKE 1193
|
1210 1220 1230
....*....|....*....|....*....|...
gi 581790339 1183 KYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTL 1215
Cdd:TIGR02785 1194 RYRGQLQLYEKALEEIYKKKVKGKYLYLLDGDH 1226
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
10-1217 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 630.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 10 VIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADP- 88
Cdd:COG1074 4 PPWTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLEDp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 89 -------ANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENiLLLEQTIDEVIEQHYDILDP-AF 160
Cdd:COG1074 84 dleelarARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEA-LLLEEAVDDLLREAYAPLDAlAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 161 IELTEQLSsdRSDDQFRMIIKQLYFFSVANpnptNWLDQLvtpyeeeaqqAQLIQLLTDLSKVFITAAydalnkaydlfs 240
Cdd:COG1074 163 ARLLDAFG--RDDDSLEELLLALYKLRSRP----DWLEEL----------AELDEALEALREALLKAK------------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 241 mmdgvdkhlaviederrlmgrvleggfidipyltdhefgarlpnvtakikeanemmvDALEDAKLQYKkykslidkvknd 320
Cdd:COG1074 215 ---------------------------------------------------------EALAALREALA------------ 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 321 yfsreaddlkadmQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDgsPSEIAESYRQHFQEILV 400
Cdd:COG1074 226 -------------AAAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDED--APWVAERLRERYRHILV 290
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 401 DEYQDTNRVQEKILSCIKTGDEH-NGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFtiDGDGTGRRIDLSQNFRSRKEVL 479
Cdd:COG1074 291 DEFQDTSPLQWEILRRLAGEALAdGRTLFLVGDPKQSIYRFRGADPELFLEARRAL--EGRVDGERLTLTTNFRSTPEVV 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 480 STTNYIFKHMMDEQVGEVKYDEAAQLYYGApydesDHPVNLKVLVEADQEHSDLTgsEQEAHFIVEQVKDILEHQKvydM 559
Cdd:COG1074 369 DAVNALFAQLMGAGFGEIPYEPVEALRPGA-----YPAVELWPLEPDDVSEEDAR--EREARAVAARIRRLLAEGT---T 438
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 560 KTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQ 639
Cdd:COG1074 439 VEGGGRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFG 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 640 FKEDELAQIRILSPNDDyFYQSIVNYindeaadailvDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLI 719
Cdd:COG1074 519 LSDEDLAALAADRKGES-LWEALRAY-----------ERLARALERLRALRELARRLGLAELLERLLEETGLLERLLALP 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 720 GGRGRRAN---LYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDfGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYsg 796
Cdd:COG1074 587 GGERRLANllhLDELLQLALEYEQTGGPGLAGFLRWLERLIEDGGD-EEKRRLESDADAVRIMTIHKSKGLEFPVVFL-- 663
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 797 lskdfnkrdlkqpvilnqqfglgmdyfdvdkemafpslasVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDK 876
Cdd:COG1074 664 ----------------------------------------PALRERARAEELAEELRLLYVALTRARDRLVLSGAVKKKD 703
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 877 Slleleqlsisgehiavnerltspnpfhliysilskhqsasipddlkfekdiaqvedssrpnvnisiiyfedvstetild 956
Cdd:COG1074 704 A------------------------------------------------------------------------------- 704
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 957 nneyrsvnqletmqngnedvkaqikhqldyqypyvndtkkpskqsvselkrqyeteESGTSYERvrqyrigfstyerpkf 1036
Cdd:COG1074 705 --------------------------------------------------------EKESSWLA---------------- 712
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1037 lseqgkrkanEIGTLMHTVMQHLPFKKERisevELHQYIDGLIDKHIIEADAKKDIRmDEIMTFINSELYSIIAEAEQVY 1116
Cdd:COG1074 713 ----------RRGTLVHRLLEHLDFSAPA----ELRAALARLLARGGLDEEEAEALA-EALLAFLATPLLAELFAAAEVL 777
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1117 RELPFVvnqalvdqLPQGDEDVS-IIQGMIDLIFVKDGVHYFVDYKTDafnrRRGMTDEEigtQLKNKYKIQMKYYQNTL 1195
Cdd:COG1074 778 REVPFL--------LPDLYRGLGgLLKGRIDLVFEDDGRVYIVDYKTN----RLGPDDEE---YLPERYRLQLALYALAL 842
|
1210 1220
....*....|....*....|...
gi 581790339 1196 QTIL-NKEVKGYLYFFKFGTLQL 1217
Cdd:COG1074 843 ERLLpGRPVRAGLYFTDRGRLVE 865
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
12-868 |
2.02e-88 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 302.24 E-value: 2.02e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 12 WTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASiadpana 91
Cdd:COG0210 7 LNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLA------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 92 hlknqrikiHQAQISTLHSFCLKLIQQHYDVLNIDPNFRtsseaenillleqtidevieqhydILDpafielteqlssdr 171
Cdd:COG0210 80 ---------RGLWVGTFHSLALRILRRHAELLGLPPNFT------------------------ILD-------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 172 SDDQFRmIIKQLyffsvanpnptnwldqlvtpyeeeaqqaqliqlltdlskvfitaaydalnkaydlfsmmdgvdkhlav 251
Cdd:COG0210 113 GDDQLR-LIKEL-------------------------------------------------------------------- 123
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 252 iederrlmgrvleggfidipyltdhefgarlpnvtakIKEANemmvdaLEDAKLQYKKYKSLIDKVKNDYFSreADDLKA 331
Cdd:COG0210 124 -------------------------------------LKELG------LDEKRFPPRELLSLISRAKNEGLT--PEELAE 158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 332 DMQQlaprvKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDgspsEIAESYRQHFQEILVDEYQDTNRVQE 411
Cdd:COG0210 159 LLAA-----DPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENP----EVLEKYQNRFRYILVDEYQDTNPAQY 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 412 KILSCIKTGdehNGNLFMVGDVKQSIYKFRQADPSLFiekyQRFTIDGDGTgRRIDLSQNFRSRKEVLSTTNYIFKHMmD 491
Cdd:COG0210 230 ELLRLLAGD---GRNLCVVGDDDQSIYGFRGADPENI----LRFEKDFPDA-KVIKLEQNYRSTQNILDAANAVIANN-P 300
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 492 EQVGEvkydeaaQLyygapydESDHPVNLKV-LVEADQEHsdltgseQEAHFIVEQVKDILEHQkvydmktgsyrsATYK 570
Cdd:COG0210 301 GRLGK-------NL-------WTDNGEGEKVrLYVAPDEE-------EEARFVADEIRELHEEG------------VPLS 347
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 571 DIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIR- 649
Cdd:COG0210 348 DIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANPDDDVALLRILNVPRRGIGAATLERLRe 427
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 650 ILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIG--GRGRRAN 727
Cdd:COG0210 428 AAREEGISLLEALRDLGELAGLSGRAAKALRRFAELLEALRAAAERLPLEELLEALLDESGYEEELREEAGeeAERRLEN 507
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 728 LYGLFNKAIEF-ENSSFRGLYQFIRFIDELiergkdfGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFnkrdl 806
Cdd:COG0210 508 LEELVDAAARFeERNPGASLEAFLEELALL-------SDLDAADEDEDAVTLMTLHAAKGLEFPVVFLVGLEEGL----- 575
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581790339 807 kqpvilnqqfglgmdyfdvdkemaFPSlasvaYKAVAEKELVSEEMRLVYVALTRAKEQLYL 868
Cdd:COG0210 576 ------------------------FPH-----QRSLDDEEELEEERRLFYVAITRARERLYL 608
|
|
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
16-868 |
4.88e-52 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 196.53 E-value: 4.88e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 16 QWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEAsiADPANahlkn 95
Cdd:TIGR01073 9 QREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPV--AEDIW----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 96 qrikihqaqISTLHSFCLKLIQQHYDVLNIDPNFrtsseaenillleqtidevieqhyDILDPAfielteqlssdrsddq 175
Cdd:TIGR01073 82 ---------ISTFHSMCVRILRRDIDRIGINRNF------------------------SIIDPT---------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 176 frmiikqlyffsvanpnptnwldqlvtpyeeeaqqaqliqlltdlskvfitaaydalnkaydlfsmmdgvdkhlavieDE 255
Cdd:TIGR01073 113 ------------------------------------------------------------------------------DQ 114
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 256 RRLMGRVLeggfidipyltdhefgarlpnvtakikeaNEMMVDAledAKLQYKKYKSLIDKVKNDY-----FSREADDlk 330
Cdd:TIGR01073 115 LSLMKTIL-----------------------------KDKNLDP---KKFEPRSILGTISNAKNELlppedFAKEATN-- 160
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 331 admqqlaprvkYLARIVKDVMSEFNRKKRSKNILDFSDyehfaLQILTNE--DGSPsEIAESYRQHFQEILVDEYQDTNR 408
Cdd:TIGR01073 161 -----------YFEKVVAEVYQEYQKRLLRNNALDFDD-----LIMTTINlfQRVP-DVLEYYQRKFQYIHVDEYQDTNR 223
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 409 VQEKIlscIKTGDEHNGNLFMVGDVKQSIYKFRQADpslfIEKYQRFTID-GDGTgrRIDLSQNFRSRKEVLSTTNYIFK 487
Cdd:TIGR01073 224 AQYTL---VRLLASRFRNLCVVGDADQSIYGWRGAD----IQNILSFEKDyPNAT--TILLEQNYRSTKNILQAANEVIE 294
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 488 HmmdeqvgevkydeaaqlyygapyDESDHPVNLK---------VLVEADQEHsdltgseQEAHFIVEQvkdILEHQkvyd 558
Cdd:TIGR01073 295 H-----------------------NSNRKPKNLWtenssgdkiTYYEADTER-------DEAQFVAGE---IDKLV---- 337
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 559 mKTGSYRsatYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLV-------- 630
Cdd:TIGR01073 338 -KNGERK---YGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIANPDDDLSLLriinvpkr 413
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 631 GLMRSVIYQFkeDELAQIRILSpnddyFYQSI--VNYINDEAADAilVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYND 708
Cdd:TIGR01073 414 GIGASSLEKI--VNYALELNIS-----LFEAIgeIDEIGGLAAKS--ANALLAFATMIENLRQQQEYLSPTELVEEVLDK 484
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 709 HYVIQYF--SGLIGGRGRRANLYGLFNKAIEFENSS-------FRGLYQFIRFIDELiergkdfgEENVVGpndNVVRMM 779
Cdd:TIGR01073 485 SGYREMLkaEKTEEAQSRLENLDEFLSVTKEFEDESedkslidFLTDLALVSDLDEL--------EETEEG---GAVTLM 553
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 780 TIHSSKGLEFPFViysglskdfnkrdlkqpvilnqqFGLGMdyfdvdKEMAFPSLASVAykavAEKELvSEEMRLVYVAL 859
Cdd:TIGR01073 554 TLHAAKGLEFPVV-----------------------FLIGM------EEGVFPHSRSLM----DEKEL-EEERRLAYVGI 599
|
....*....
gi 581790339 860 TRAKEQLYL 868
Cdd:TIGR01073 600 TRAEEELYL 608
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
12-455 |
7.91e-48 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 172.04 E-value: 7.91e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 12 WTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVdqriqeasiadpaNA 91
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERI-------------LK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 92 HLKNQRIKihQAQISTLHSFCLKLIQQHYDVLNIDPNFRTsseaenillleqtidevieqhydildpafielteqlssdr 171
Cdd:pfam00580 68 LLGKAELS--ELNISTFHSFCLRILRKYANRIGLLPNFSI---------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 172 sddqfrmiikqlyffsvanpnptnwldqlvtpYEEEAQQAQLIQLLTDLSKvfitaaydalnkaydlfsmmdgvdkhlav 251
Cdd:pfam00580 106 --------------------------------LDELDQLALLKELLEKDRL----------------------------- 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 252 iederrlmgrvleggfidipyltdhefgarlpnvtakikeanemmvdALEDAKLQYKKYKSLIDKVKNDYFSREaddlka 331
Cdd:pfam00580 125 -----------------------------------------------NLDPKLLRKLELKELISKAKNRLLSPE------ 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 332 dmQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEdgspSEIAESYRQHFQEILVDEYQDTNRVQE 411
Cdd:pfam00580 152 --ELQQGAADPRDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSD----PELLEAYRERFKYILVDEFQDTNPIQY 225
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 581790339 412 KILSCIKTGdehNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRF 455
Cdd:pfam00580 226 RLLKLLAGG---HENLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
29-871 |
2.85e-47 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 184.89 E-value: 2.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 29 VAAAAGSGKTAVLVERIIqKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADpaNAHLKNQ----------RI 98
Cdd:TIGR02784 15 VSANAGSGKTHVLTQRVI-RLLLAGTEPSKILCLTYTKAAAAEMQNRVFKRLGEWAVLD--DADLRARlealegkrpdAA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 99 KIHQA--------------QISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQ---HYDILDPAFI 161
Cdd:TIGR02784 92 KLAEArrlfaraletpgglKIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLEEARRALLAGpaaPDDALADALA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 162 ELTEQLSSDRSDDQFRMIIKQLYFFSvanpnptNWLDQLVTpyeeEAQQAQLIQLL---------TDLSKVFITAAYDAL 232
Cdd:TIGR02784 172 TVLEAAGETGLEALLAEIVARRDALM-------AFLDEAGG----EGAEARLRRALglapgdtaeDLLEAVWPLPGLPRL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 233 nkAYDLF-SMMDGVD--KHLAVI----EDERRLMGRVLEGGFIDIPYLTDHEFGARLPNV-TAKIKEANEMMVDALEDAK 304
Cdd:TIGR02784 241 --ALALIaALLKSGGgsKDAAAAlsqlREAAAEPDPVARLDLLLGAFLTSKGEPKSASFViKKAIQKSLPDLAEALEDAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 305 LqykKYKSLIDKVKndyFSREADDLKADMQqLAPRvkYLARivkdvmseFNRKKRSKNILDFSDYEHFALQILTNEDgsp 384
Cdd:TIGR02784 319 S---RVEALRERLR---ALRMAQRTLAALR-LAAR--LLQR--------YARLKKARGLLDFNDLIERTVALLARPG--- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 385 seIAE--SYR--QHFQEILVDEYQDTNRVQEKILSCI----------KTGDEHNgnLFMVGDVKQSIYKFRQADPSLFIE 450
Cdd:TIGR02784 379 --AGAwvHYKldRGIDHILVDEAQDTSPEQWDIIQALaeeffsgegaRSGVERT--IFAVGDEKQSIYSFQGADPERFAE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 451 KYQRFTIDGDGTGR---RIDLSQNFRSRKEVLSTTNYIFKhmmdeqvgevkyDEAAQLYYGAPYDE-------SDHP--V 518
Cdd:TIGR02784 455 ERREFSRKVRAVGRkfeDLSLNYSFRSTPDVLAAVDLVFA------------DPENARGLSADSDApvheafrDDLPgrV 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 519 NLKVLVEAD--QEHSDLTGS---EQE-------AHFIVEQVKDILEHQkvyDMKTGSYRSATYKDIVILERSFGQARN-L 585
Cdd:TIGR02784 523 DLWDLISKEegEEPEDWTDPvdeLGErapevrlAERIAAEIRAWLDRG---TPIPGRGRAVRPGDILVLVRKRDAFFSaL 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 586 QQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKED---ELAQIRILSPNDDYFYQSi 662
Cdd:TIGR02784 600 IRALKRRGIPVAGADRLKLTSHIAVKDLMALGRFVLQPEDDLSLAALLKSPLFGLDEDdlfRLAAGRSGGSLWAALRRR- 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 663 vnyindEAADAILVDKLKMFLSDiqsyqqySKDHPVYQLidkfyndhyviqyFSGLIGGRGRRANLYG------------ 730
Cdd:TIGR02784 679 ------EAEFAATLAVLRDWLSL-------ADFLTPFEF-------------YARLLGRDGGRRKLLArlgaeaedilde 732
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 731 LFNKAIEFENSSFRGLYQFIRFIDEL---IERGKDfgeenvvgPNDNVVRMMTIHSSKGLEFPFVIY-SGLSKDFNKRDL 806
Cdd:TIGR02784 733 FLSQALAYERTGLPGLQAFLSWLEADdpeIKREMD--------QARDEVRVMTVHGAKGLEAPVVFLvDTGSKPFASQRA 804
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 581790339 807 kqPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELvSEEMRLVYVALTRAKEQLYLIGR 871
Cdd:TIGR02784 805 --PLLLATGGSGGKAPLWRPASAFDPSLSAAARERLKERAE-DEYRRLLYVAMTRAEDRLIVCGY 866
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
28-1213 |
8.04e-41 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 164.14 E-value: 8.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 28 LVAAAAGSGKTAVLVERIIQKILRDG-IDVDRLLVVTFTNLSAREMKHRVDQRIQEASIA-------DPANAHLKNQ--- 96
Cdd:TIGR00609 13 LIEASAGTGKTFTIAQLYLRLLLEGGpLTVEEILVVTFTNAATEELKTRIRGRIHQALRAlkaaltsQELPEPLKEAiqd 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 97 ----------RIKIHQ---AQISTLHSFCLKLIQQH-YDVLNIDPNFRTSSEAeniLLLEQTIDEVIEQHYdildpafie 162
Cdd:TIGR00609 93 ekvkqaitrlRNALATmdeAAIYTIHGFCQRMLEQHaFESDEIFDVELIEDES---LLLAEITKDFWRRNF--------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 163 lteqlSSDRSDdqfrmiiKQLYFFSV-ANPnptnwldqlvtpyeeeaqQAQLIQLLTDLSKvfitAAYDAlnkaydlfsm 241
Cdd:TIGR00609 161 -----YNLPFD-------IAQIVLKTkKSP------------------QAVLTQILADLLL----QSYLA---------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 242 mdgvdkhlaviederrlmgrvleggfidipyltdheFGARLPNVTAKIKEANEMMVDALedaKLQYKKYKSlIDKVkndy 321
Cdd:TIGR00609 197 ------------------------------------FPSPPLDLEQLIKWHEQIYKDLD---KLDHAVFEE-IDKL---- 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 322 fsreaDDLKADMQQLAPRVKYlaRIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPseIAESYRQHFQEILVD 401
Cdd:TIGR00609 233 -----NAERNNLFCLKDRVFL--TLLKEVQEELKKEKKRRREIGFDDLLSRLETALKSAEGEK--LAQAIREQYPIALID 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 402 EYQDTNRVQEKILSCIKTGDEHNGnLFMVGDVKQSIYKFRQADpsLFIEKYQRFTIDgdgtgRRIDLSQNFRSRKEVLST 481
Cdd:TIGR00609 304 EFQDTDPQQYRIFSKLFIAQKETS-LFLIGDPKQAIYSFRGAD--IFTYLQAKSKAD-----ARYTLGTNWRSTPALVGS 375
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 482 TNYIFkhmmdeqvgevkydeaAQLYYGAPYDESDHPVnlkvlvEADQEHSDLT----GSEQEA-HFIVEQV--------- 547
Cdd:TIGR00609 376 LNKLF----------------SLISNPFLEKPIFIPV------LAHQKNSKGSfvinGQEQPPiHFFTTEVesegvddyr 433
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 548 -----------KDILEHQKVYDMKTGSY---RSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQT-EVRL 612
Cdd:TIGR00609 434 qtiaqkcareiALWLASAALGLANFIATfggRPLRAGDIAVLVRGRKEANQIRKALKKAQIPSVYLSDKSSVFATeEAQE 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 613 VLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRilspNDDYFYQSIVNYIndeaadailvdklkmflsdiQSYQQY 692
Cdd:TIGR00609 514 LLALLEALLEPENEGTLRAALASSIFGLSALELETLN----QDEITWERVVEKF--------------------REYHDI 569
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 693 SKDHPVYQLIDKFYNDHyvIQYFSGLIGGRGRR-----ANLYGLFNKAIEFEnssfRGLYQFIRFIDELIERGKDFGEEN 767
Cdd:TIGR00609 570 WRKIGVLAMFQRLMLEK--GIGERLLSQPGGERiltnlLHLAELLQEAAHQE----RNKLSLLRWLEDQISNEEEEEEEI 643
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 768 VVGPNDN-VVRMMTIHSSKGLEFPFVIYSGLSkDFNKRDlkqpvilnqqFGLGMDYFDVDKEMAFPSLASVAYKAVAEKE 846
Cdd:TIGR00609 644 IRLESDAeLVKIVTIHKSKGLEYPIVFLPFIT-DAKKSN----------FASLHDQHSHEYQLYDFNQSEENQKLARVER 712
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 847 LvSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEhiavnerltspnpfHLIYSILSKHQSASIPDDLKFEK 926
Cdd:TIGR00609 713 L-AEDLRLLYVALTRAKKQLFIGIAPLITSKLSNLAYSALHNS--------------ALGYQKQDGETDNITGLKQCLAA 777
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 927 diaqvedsSRPNVNISIIYFEDVSTETILDNNEYRSVNQLETMQnGNEDVKAQIKhqldyqypyvndtkkpskqSVSELK 1006
Cdd:TIGR00609 778 --------LADPAGISSIPAKPIGANSSKKEPASTALLEARTFH-RRIRENWRIT-------------------SFSSLK 829
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1007 RQYETEESgtsyERVRQYRIGFSTYERPKFLSEQGKrkanEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEA 1086
Cdd:TIGR00609 830 ELEEAVTE----EPAPGLDYEVSSLEISAQDFPKGK----KTGTLLHAILESLIFSQAADLEKQNNLIAEKLKKTGLEGL 901
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1087 DAKKDIRM-----DEIMTFINS------ELYSIIAEAE--------QVYRELPFVVNQALVDQLPQGDEDVSI---IQGM 1144
Cdd:TIGR00609 902 WEPELQEWlekmlNTPLTFSRAitlsqiDPEDRQREMEfllpinpeFQKQKLNFVIRAYPDRAGSPDLHFQLLrglLKGF 981
|
1210 1220 1230 1240 1250 1260 1270
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581790339 1145 IDLIFVKDGVHYFVDYKTD-------AFNRRRgmTDEEIgtqLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFG 1213
Cdd:TIGR00609 982 IDLVFEHNGRYYILDYKSNwlgkdasDYSPEA--LTEAI---LKERYDLQYLIYTLALHRYLRKRLKDYDYERHFG 1052
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
14-868 |
7.19e-35 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 143.47 E-value: 7.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 14 DAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIqeasiadpanahl 93
Cdd:PRK11773 12 DKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLL------------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 94 knqRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRtsseaenillleqtidevieqhydILDpafielteqlssdrSD 173
Cdd:PRK11773 79 ---GTSQGGMWVGTFHGLAHRLLRAHWQDANLPQDFQ------------------------ILD--------------SD 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 174 DQFRMI---IKQLyffsvaNPNPTNWldqlvtPyeeeAQQAQLiqlltdlskvFITAAYDalnkaydlfsmmdgvdkhla 250
Cdd:PRK11773 118 DQLRLLkrlIKAL------NLDEKQW------P----PRQAQW----------YINGQKD-------------------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 251 viederrlmgrvlEGgfidipyltdhefgaRLPNvtaKIKEANemmvDALEDAKLQ-YKKYKSLIDkvkndyfsreaddl 329
Cdd:PRK11773 152 -------------EG---------------LRPQ---HIQSYG----DPVEQTWLKiYQAYQEACD-------------- 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 330 kadmqqlaprvkylarivkdvmsefnrkkRSkNILDFSDYEHFALQILTNedgSPsEIAESYRQHFQEILVDEYQDTNRV 409
Cdd:PRK11773 183 -----------------------------RA-GLVDFAELLLRAHELWLN---KP-HILQHYQERFTHILVDEFQDTNAI 228
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 410 QEKILScIKTGDEhnGNLFMVGDVKQSIYKFRQADpslfIEKYQRFTIDGDGTgRRIDLSQNFRSRKEVLSTTNYIFKHm 489
Cdd:PRK11773 229 QYAWIR-LLAGDT--GKVMIVGDDDQSIYGWRGAQ----VENIQRFLNDFPGA-ETIRLEQNYRSTANILKAANALIAN- 299
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 490 MDEQVG-----EVKYDEAAQLYygAPYDESDhpvnlkvlveadqehsdltgseqEAHFIVEQVKDILEHQkvydmktgsy 564
Cdd:PRK11773 300 NNGRLGkelwtDGGDGEPISLY--CAFNELD-----------------------EARFVVERIKTWQDNG---------- 344
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 565 rsATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDiylVGLMRSV------Iy 638
Cdd:PRK11773 345 --GALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLRLIANRNDD---AAFERVVntptrgI- 418
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 639 qfKEDELAQIRILSPNDDY-FYQSIVNYINDE-----AADAilvdkLKMFLSDIQSYQQYSKDHPVYQLIDkfyndhYVI 712
Cdd:PRK11773 419 --GDRTLDVVRQTARDRQLtLWQACRALLQEKvlagrAASA-----LQRFIELIDALAQETADMPLHEQTD------RVI 485
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 713 QYfSGLIG---------GRGRRANLYGLFNKAIEFENSsfrglyqfirfiDELIERGK----------DFGEENvVGPND 773
Cdd:PRK11773 486 KD-SGLRAmyeqekgekGQARIENLEELVTATRQFSYP------------DEDEDLTPlqaflshaalEAGEGQ-ADAHE 551
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 774 NVVRMMTIHSSKGLEFPFViysglskdfnkrdlkqpvilnqqFGLGMDyfdvdkEMAFPSLASvaykaVAEKELVSEEMR 853
Cdd:PRK11773 552 DAVQLMTLHSAKGLEFPLV-----------------------FIVGME------EGLFPSQMS-----LEEGGRLEEERR 597
|
890
....*....|....*
gi 581790339 854 LVYVALTRAKEQLYL 868
Cdd:PRK11773 598 LAYVGITRAMQKLTL 612
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
31-946 |
6.86e-32 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 135.10 E-value: 6.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 31 AAAGSGKTAVLVERIIQKILRdGIDVDRLLVVTFTNLSAREMKHRVD---------------QRIQEASIADPANAHLKN 95
Cdd:PRK13909 5 ASAGSGKTFALSVRFLALLFK-GANPSEILALTFTKKAANEMKERIIdtllnlekekeeselNELEEKLGLSKEELLNKR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 96 QRIKIHQAQ----ISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENiLLLEQTIDEV-IEQHYDILdpAFIELTEQLSSD 170
Cdd:PRK13909 84 DKVYQEFLNselkISTIDAFFQKILRKFCLNLGLSPDFSIKEDTKE-ELNEKFLSALsKEELLELL--AFIKQCESKKNN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 171 RSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLltdlskvfITAAYDALNKAYDLFSMMDGVDKHLa 250
Cdd:PRK13909 161 SFFELLEKLYEKNNELKLFEKAKNPIEFDEEKFLEELRSLKQQIQS--------IETASKNAKKAFKKEDFEELLNSSK- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 251 viederrlMGRVLEGGFIDIPYLTDHEFGARLpnvtAKIKEANEMMVDALEDAKLqyKKYKSLIDKVKNdyfsreaddlk 330
Cdd:PRK13909 232 --------TWLEKESEYRYFKKLYNEELDAEF----EELKNALKRYYDAKENYKL--SKLFKLLQLYKE----------- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 331 admqqlaprvkylARivkdvmSEFNRKKrskNILDFSDYEHFALQILTNEdGSPSEI----AESYRQHfqeILVDEYQDT 406
Cdd:PRK13909 287 -------------AK------NELNKKK---NALDFDDISKKVYELLGEE-EIDKDFlyfrLDSKISH---ILIDEFQDT 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 407 NRVQEKILSC----IKTGDEHNGN--LFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGtgrridLSQNFRSRKEVLS 480
Cdd:PRK13909 341 SVLQYKILLPlideIKSGEGQKKFrsFFYVGDVKQSIYRFRGGKKELFDKVSKDFKQKVDN------LDTNYRSAPLIVD 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 481 TTNYIFKhmmdeqvgevkydEAAQLYYGAPYDESDHPVNLKVLveadqehSDLTGSEQEAHFIVEQVKDILEHqkvydmk 560
Cdd:PRK13909 415 FVNEVFK-------------KKYKNYKTQYAEQHKSGGYVEVV-------EVADESEELLEQLLQEIQFLLEK------- 467
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 561 tgsyrSATYKDIVILERSFGQARNLQQAF-KNEDIPFHVNSREGYFEQTEVRLVLSFLRAIdnplqdiylvglmrsviyQ 639
Cdd:PRK13909 468 -----GIDPDDIAILCWTNDDALEIKEFLqEQFGIKAVTESSAKLINQPEVKALIEALKYC------------------L 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 640 FKEdelaqirilsPNDDYFYQSIVNYindeaadaiLVDKLKMFLsdiqsyqqySKDHPVYQLIdkfyndHYVIQYFsGLI 719
Cdd:PRK13909 525 FGE----------EIYKHNVLKLLGK---------EPDKIPSFL---------PKEESVAEFV------KKLIEEL-KLY 569
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 720 GgrgrrANLYGLFNKAIEFENssfrglyqfirfIDELIERGKDFGEENVVGPNDNvVRMMTIHSSKGLEFPFVIY----- 794
Cdd:PRK13909 570 D-----ENLLKFLELASGYED------------IEEFLFKLEPCDKEIASEESKG-VQIMTVHKSKGLEFEHVIVcdrlg 631
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 795 ------SGLSKDFNKRDLKQpVILNQQfglGMDYFDVDkemafpslasvaYKAVAEKELVS---EEMRLVYVALTRAKEQ 865
Cdd:PRK13909 632 kpnsdsSNLLFEYDGIELWQ-IYYRIK---GRENFDKD------------YARALEKEKALkyeEEINVLYVAFTRAKNS 695
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 866 LYLIgrvKNDKS------LLELEQLSIsGEHIAVNERLTSPNPFHLIYSILSKHQSASIpddlkfekdIAQVEDSSRPNV 939
Cdd:PRK13909 696 LIVV---KKDESsgsmfeILDLKPLER-GEIEIKEPKISPKKESLITSVKLKPHGYQEQ---------VKEIEEEPKEDN 762
|
....*..
gi 581790339 940 NISIIYF 946
Cdd:PRK13909 763 DLEAIYF 769
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
365-472 |
7.18e-31 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 120.31 E-value: 7.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 365 DFSDYEHFALQILTNEdgspSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGdehNGNLFMVGDVKQSIYKFRQAD 444
Cdd:cd17932 94 DFDDLLLYALELLEEN----PDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGD---GKNLFVVGDDDQSIYGFRGAD 166
|
90 100
....*....|....*....|....*...
gi 581790339 445 PSLFIEKYQRFtidgdGTGRRIDLSQNF 472
Cdd:cd17932 167 PENILDFEKDF-----PDAKVIKLEENY 189
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
13-121 |
8.99e-30 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 117.23 E-value: 8.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 13 TDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPanah 92
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLLGEQLASGV---- 76
|
90 100
....*....|....*....|....*....
gi 581790339 93 lknqrikihqaQISTLHSFCLKLIQQHYD 121
Cdd:cd17932 77 -----------WIGTFHSFALRILRRYGD 94
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
15-866 |
4.92e-27 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 118.40 E-value: 4.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 15 AQWQSI-YATGQdVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQeasiadpanahl 93
Cdd:PRK10919 6 GQQQAVeFVTGP-CLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTLG------------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 94 knqRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILdpafieltEQLSSDRSd 173
Cdd:PRK10919 73 ---RKEARGLMISTFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEGLIEDDKVLL--------QQLISTIS- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 174 dqfrmiikqlyffsvanpnptNWLDQLVTPyeeeAQQAQLIQLLTDlsKVFItaaydalnKAYDLFsmmdgvDKHLavie 253
Cdd:PRK10919 141 ---------------------NWKNDLKTP----AQAAAGAKGERD--RIFA--------HCYGLY------DAHL---- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 254 derrlmgrvleggfidipyltdhefgarlpnvtakikeanemmvdaledaklqykkykslidkvkndyfsreaddlkadm 333
Cdd:PRK10919 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 334 qqlaprvkylarivkdvmsefnrkkRSKNILDFSDYEHFALQILTNEDgspsEIAESYRQHFQEILVDEYQDTNRVQEKI 413
Cdd:PRK10919 176 -------------------------KACNVLDFDDLILLPTLLLQRNE----EVRERWQNKIRYLLVDEYQDTNTSQYEL 226
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 414 lscIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTidgdgTGRRIDLSQNFRSRKEVLSTTNYIFKHmmDEQ 493
Cdd:PRK10919 227 ---VKLLVGSRARFTVVGDDDQSIYSWRGARPQNLVLLSQDFP-----ALQVIKLEQNYRSSGRILKAANILIAN--NPH 296
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 494 VGEVKYdeAAQLYYGAPydesdhpvnLKVLVEADQEHS--DLTGSEQEAHFIveqvkdilehqkvydmktgsyRSATYKD 571
Cdd:PRK10919 297 VFEKRL--FSELGYGDE---------LKVLSANNEEHEaeRVTGELIAHHFV---------------------NKTQYKD 344
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 572 IVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDiylVGLMRSVIYQFKEDELAQIRIL 651
Cdd:PRK10919 345 YAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDD---SAFLRIVNTPKREIGPATLQKL 421
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 652 SPNDDYFYQSIVNYINDEAADAIL----VDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNdhyvIQYFSGLI-------G 720
Cdd:PRK10919 422 GEWAMTRNKSLFTASFDMGLSQTLsgrgYESLTRFTHWLAEIQRLAEREPVAAVRDLIHG----IDYESWLYetspspkA 497
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 721 GRGRRANLYGLFNKAIE-FENSSFR---GLYQFI-RF-IDELIERGKDfgEENVvgpndNVVRMMTIHSSKGLEFPFViy 794
Cdd:PRK10919 498 AEMRMKNVNQLFSWMTEmLEGSELDepmTLTQVVtRFtLRDMMERGES--EEEL-----DQVQLMTLHASKGLEFPYV-- 568
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581790339 795 sglskdfnkrdlkqpvilnqqFGLGMDyfdvdkEMAFPSLASVaykavaEKELVSEEMRLVYVALTRAKEQL 866
Cdd:PRK10919 569 ---------------------YLVGME------EGLLPHQSSI------DEDNIDEERRLAYVGITRAQKEL 607
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
466-869 |
2.73e-17 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 85.15 E-value: 2.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 466 IDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAqlyygaPYDESDhpvNLKVLvEADQEhsdltgsEQEAHFIVE 545
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRATIYPKKILAE------TVEDGE---KIKII-EAETE-------EEEAEWIAL 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 546 QVKDILEHQKvydmktgsyrsaTYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQ 625
Cdd:pfam13361 64 EIKKLVARDE------------KYNDIAVLTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHD 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 626 DIYL--------VGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILV--------------------- 676
Cdd:pfam13361 132 SISLkrilngpkRGIGNATLERIREYKKRGLRLSDFINPDTLTYGDPFVIALEQDNIVVfdvettgldttedeiiqiaai 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 677 ---------DKLKMFLSDIQSYQ--QYSKDHPVYQLIDKFYNDHYVIQYFSGLIGgrgrraNLYGLFNKAIEFEN----- 740
Cdd:pfam13361 212 klnkkgvviESFERFLRLKKPVGdsLQVHGFSDEFLQENGETPAEALRDFLEKLE------NLRELYSILREYDDieetp 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 741 SSFRGLYQFIRFI---DELIERGKDFgeenvvgpndNVVRMMTIHSSKGLEFPFVIYSGLSkdfnkrdlkqpvilnqqfg 817
Cdd:pfam13361 286 EPEDALRNFLEIAtlsNSELEGSDIK----------ERIPIMTIHQAKGLEFDTVFLAGLE------------------- 336
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 581790339 818 lgmdyfdvdkEMAFPSlasvaYKAVAEKELVSEEMRLVYVALTRAKEQLYLI 869
Cdd:pfam13361 337 ----------EGIFPS-----YRSIKDEGNLEEERRLFYVAITRAKKRLYIS 373
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
776-870 |
3.15e-15 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 74.19 E-value: 3.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 776 VRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPvilnqqfglgmdyfdvdkemafpslasvayKAVAEKELVSEEMRLV 855
Cdd:cd18807 86 VTLMTIHASKGLEFPVVFIVGLGEGFIPSDASYH------------------------------AAKEDEERLEEERRLL 135
|
90
....*....|....*
gi 581790339 856 YVALTRAKEQLYLIG 870
Cdd:cd18807 136 YVALTRAKKELYLVG 150
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
343-862 |
1.16e-11 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 69.61 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 343 LARIVKDVMSEFNRKKRSKNILDFSDyehfalqILTNED---GSPS--EIAESYRQHFQEILVDEYQDTNRVQEKILSCI 417
Cdd:PRK10876 328 ITRALAEIRETVAQEKRRRGELGFDD-------LLSRLDsalQSEGgeALAAAIRTRYPVAMIDEFQDTDPQQYRIFRRI 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 418 KTGDEHNGnLFMVGDVKQSIYKFRQADpsLFIEKYQRFTIDGDGTgrridLSQNFRSRKEVLSTTNYIFKHMmdeqvgev 497
Cdd:PRK10876 401 YRHQPETA-LLLIGDPKQAIYAFRGAD--IFTYMKARSEVSAHYT-----LDTNWRSAPGMVNSVNKLFSQT-------- 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 498 kydEAAQLYYGAPY-----DESDHPVNLKVlveADQEHSDLT-----------GSEQE--AHFIVEQVKDIL---EHQKV 556
Cdd:PRK10876 465 ---DDPFLFREIPFipvkaAGKNQALRFVV---KGETQPAMKfwlmegegvgvGDYQQtmAQQCAAQIRDWLqagQRGEA 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 557 YDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIP-FHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRS 635
Cdd:PRK10876 539 LLMNGDDSRPVRASDITVLVRSRQEAALIRDALTLLAIPsVYLSNRDSVFETLEAQEMLWLLQAVLAPERERTLRSALAT 618
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 636 VIYQFkedELAQIRILSpnddyfyqsivnyiNDEAA-DAiLVDKLkmflsdiQSYQQYSKDHPVYQLIDKFYNDHYVIQY 714
Cdd:PRK10876 619 SMMGL---DALDIDALN--------------NDERAwDA-LVEEF-------DGYRQIWRKRGVLPMLRALMSARNIAEN 673
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 715 FSGLIGGRGRRANLYG---LFNKA---IEFENSSFRGLYQFIrfideliergkdfgeenvVGPNDN-------------V 775
Cdd:PRK10876 674 LLATAGGERRLTDILHigeLLQEAssqLDSEHALVRWLAQQI------------------LEPDSQassqqlrlesdkhL 735
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 776 VRMMTIHSSKGLEFPFVIYSGLSkdfNKRDLKQPVilnqqfglgmdYFDVDKEMAFPSL-ASVAYKAVAEKELVSEEMRL 854
Cdd:PRK10876 736 VQIVTIHKSKGLEYPLVWLPFIT---NFRVQDQAF-----------YHDRHSFEAVLDLnAAEESVALAEEERLAEDLRL 801
|
....*...
gi 581790339 855 VYVALTRA 862
Cdd:PRK10876 802 LYVALTRS 809
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
253-1209 |
1.12e-07 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 56.29 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 253 EDERRLMGRVLEGGFIDIPYLTDHEFGARLPNVTAKIK------EANEMMV-DALEDAK--LQY----KKYKSLIDKVKN 319
Cdd:COG3857 40 QAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGATrpllsdAGKRMLLrKILEEHKdeLKVfaraADKPGFIEQLAE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 320 DY--FSR---EADDLKADMQQLAPRVKYLARIvkdvMSEFNRKKRSKNIlDFSDYEHFALQILTNedgspseiAESYRQH 394
Cdd:COG3857 120 LIteLKRygiTPEDLEEAAELLKEKLRDLALI----YEAYEEKLAGRYI-DSEDLLRLLAEKLEK--------SEFLEGA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 395 fqEILVDEYQDTNRVQEKIL-SCIKTGDEHNGNLFMVGDVKQSIYKFRQadpslFIEKYQRFtidgdgtGRRIDLSQNFR 473
Cdd:COG3857 187 --EIYIDGFTDFTPQELELLeALLKKAKEVTITLTLDPDELDLFSATGE-----TYERLLEL-------AKENGVEVEFK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 474 SRKEVLSTTNYIFKHMMDEQVGEVKYDEAAqlyygapydesdhpvnlkvlveadqehsdltGSEQEAHFIVEQVKDILEH 553
Cdd:COG3857 253 KSPELAHLERNLFAYPPEEEPEGIEIIEAA-------------------------------NRRAEVEAVAREIRRLVRE 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 554 QKvydmktgsYRsatYKDIVILERSFGQ-ARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPL--QDI--- 627
Cdd:COG3857 302 EG--------YR---YRDIAVVVRDLEAyAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVRSNFryEDVfrl 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 628 ----YLVGLMRSVI--------------YQFKEDELAQIRILSPNDDYFYQSIvNYINDEAADAIlvDKLKMFLSDIQSY 689
Cdd:COG3857 371 lktgLLRPLSREEIdrlenyvlaygirgRRWLERYLEEEEELTDEEEEDLERL-NELRDRLLEPL--LPLRERLKKAKTV 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 690 QQYSKDhpVYQLIDKFYNDHYVIQYFSGLIGGRGRRAN--------LYGLFNKAIEFENSSFRGLYQFIRFIDELIErGK 761
Cdd:COG3857 448 REWAEA--LYEFLEELGVPEKLEEWREAEEAGDLEEAReheqawnaLIELLDELVEVLGDEKLSLEEFLRILESGLE-EL 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 762 DFGeenVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKD-FNKRDLKQPVILnqqfglgmdyfDVDKEmafpSLASVAYK 840
Cdd:COG3857 525 TFG---LIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGvFPARPREDGLLS-----------DEERE----RLNELGLE 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 841 -AVAEKELVSEEMRLVYVALTRAKEQLYLIgrvkndkslleleqlsisgehiavnerltspnpfhliYSILS---KHQSA 916
Cdd:COG3857 587 lPPTSRERLLEERFLFYRALTRASERLYLS-------------------------------------YPLADeegKALLP 629
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 917 SIpddlkFEKDIAQVEDSSRPNVNISIIYFEDVSTETILdnNEYRSVNQLETMQNGNEDVKAQIKhqldyqypyvndtkk 996
Cdd:COG3857 630 SP-----LIDRLRELFPELEERSLLEEELEYIGTPESAL--SELAAALRQLELAPLWWDVYKWLL--------------- 687
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 997 psKQSVSELKRQYETeesgtsyervrQYRiGFSTY-----ERPKF-LSeqgkrkANEIGTLMHTVMQHLpFKK------- 1063
Cdd:COG3857 688 --KLSVSRLETYAAC-----------PFQ-FFLRYglklkEREEYeLD------APDRGTLFHAVLERF-YKElkeegld 746
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1064 -ERISEVELHQYIDGLIDKhIIEADAKKDIRMDEIMTFINSELYSIIAEAEQ-------------VYRELPFVVNQALVD 1129
Cdd:COG3857 747 wADLSDEELEELLEEAVEE-LAPELQNGILLSSARYRYLLERLKRLLKRARRwleeearrsgfepVALELSFGPEGGLPP 825
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 1130 Q-LPQGDEDVSIIQGMIDLI--FVKDGVHYFV-DYKTdafnRRRGMTDEEI--GTQLknkykiQMKYYQNTLQTIL-NKE 1202
Cdd:COG3857 826 LeLELPNGRKIRLRGRIDRIdrLESDGRYLRIiDYKS----GSKKFDLDDVyyGLAL------QLPLYLDAALENLeGKE 895
|
....*....
gi 581790339 1203 VK--GYLYF 1209
Cdd:COG3857 896 AEpaGALYF 904
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
12-475 |
1.19e-07 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 56.11 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 12 WTD---AQWQSIYAT----------------GQD-VLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSARE 71
Cdd:PRK11054 177 WTEamlEEYADFFSQvessplnpsqaravvnGEDsLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEE 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 72 MKHRVDQRiqeasiadpanahLKNQRIkihqaQISTLHSFCLKLIQQhydvlnidpnfrTSSEAENILLLEqtidevieq 151
Cdd:PRK11054 257 MDERIRER-------------LGTEDI-----TARTFHALALHIIQQ------------GSKKVPVISKLE--------- 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 152 hydildpafielteqlssdrSDDQFRmiikQLYFFSVanpnptnWLDQLvtpYEEEAQQAQLIQLLTDLskvfitaayda 231
Cdd:PRK11054 298 --------------------NDSKAR----HALLIAE-------WRKQC---SEKKAQAKGWRQWLTEE----------- 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 232 lnkaydlfsmMDGVDKHLAVIEDER---RLMGRvLEggfidipyltdhefgaRLPNVTAKIKEANEMMVDaledaklqyk 308
Cdd:PRK11054 333 ----------LQWDVPEGNFWDDEKlqrRLASR-LE----------------RWVSLMRMHGGSQAEMIA---------- 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 309 kyksLIDKVKNDYFSREaddlkadMQQLAPRVKYLARIVKDvmsefnrkkrsKNILDFSDYEHFALQILtnEDG---SPs 385
Cdd:PRK11054 376 ----QAPEEVRDLFQKR-------LKLMAPLLKAWKKALKA-----------ENAVDFSGLIHQAVNYL--EKGrfiSP- 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 386 eiaesyrqhFQEILVDEYQDTNRVQEKILSCIKTGDEHNgNLFMVGDVKQSIYKFRQADPSLFIEKYQRFtidGDGTGRR 465
Cdd:PRK11054 431 ---------WKHILVDEFQDISPQRAALLAALRKQNSQT-TLFAVGDDWQAIYRFSGADLSLTTAFHERF---GEGDRCH 497
|
490
....*....|
gi 581790339 466 IDLSQNFRSR 475
Cdd:PRK11054 498 LDTTYRFNSR 507
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
27-170 |
5.24e-06 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 50.60 E-value: 5.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 27 VLVAAAAGSGKTAVLVERIIQKILRDgiDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANahlknqRIKIHqaqis 106
Cdd:COG3972 176 QRIRGVAGSGKTVLLAAKAAYLALKH--PGWRILVTCFNRSLADHLRDLIPRFLRRFSNGEPED------NVKLI----- 242
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581790339 107 TLHSFCLKLIQQHydvlNIDPNFRTSS----EAENILLLEQTIDEVIEQHYD--ILD------PAFIELTEQLSSD 170
Cdd:COG3972 243 VFHAWGGKLLKQY----GIPPLTFSQPneafDEACKALLEAIQGEIIPPIYDaiLIDeaqdfePEFLRLLYQLLKP 314
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
776-869 |
3.11e-05 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 42.56 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 776 VRMMTIHSSKGLEFPFVIysglskdfnkrdLKQPVILNQqfglgmdyfdvdkemafpslasvaykavaekELVSEEMRLV 855
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVF------------LVDPDLTAH-------------------------------YHSMLRRRLL 38
|
90
....*....|....
gi 581790339 856 YVALTRAKEQLYLI 869
Cdd:pfam13538 39 YTAVTRARKKLVLV 52
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
771-870 |
3.16e-05 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 48.29 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 771 PNDNVVRMMTIHSSKGLEFPFVIYSGLskdfnkrdlkqpvilnqqfglgmdyfdvdkemafpslasvayKAVAEKELVSE 850
Cdd:COG3972 484 WKDGGVTISTIHRAKGLEAPVVIIVGL------------------------------------------DQLAKGESLER 521
|
90 100
....*....|....*....|
gi 581790339 851 EMRLVYVALTRAKEQLYLIG 870
Cdd:COG3972 522 LRNLLYVAMTRARGWLVVSG 541
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
474-590 |
5.14e-05 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 44.53 E-value: 5.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 474 SRKEVLSTTNYIFKHmmdeqvgeVKYDEAAQLYYGAPYDESdhpvnlKVLVEADQEHSdltgseqEAHFIVEQVKDILEH 553
Cdd:cd18807 1 STKNILDAANSLIKQ--------NKNRPKKPLKAGNKSGGP------VELLLAKDEAD-------EAKAIADEIKRLIES 59
|
90 100 110
....*....|....*....|....*....|....*..
gi 581790339 554 QKVydmktgsyrsaTYKDIVILERSFGQARNLQQAFK 590
Cdd:cd18807 60 GPV-----------QYSDIAILVRTNRQARVIEEALR 85
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
27-81 |
1.11e-04 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 43.36 E-value: 1.11e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 581790339 27 VLVAAAAGSGKTAVLVeRIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQ 81
Cdd:pfam13245 14 VLLTGGPGTGKTTTIR-HIVALLVALGGVSFPILLAAPTGRAAKRLSERTGLPAS 67
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
28-102 |
3.00e-04 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 41.70 E-value: 3.00e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 581790339 28 LVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVdqrIQEASIADPANAHLKNQRIKIHQ 102
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLDNIL---VDEAAQILEPETSRLIDLALDQG 74
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
779-870 |
4.08e-04 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 40.24 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 779 MTIHSSKGLEFPFVIYsglskdfnkrdlkqpvilnqqfglgmdyfdvdkemafpslasvaykaVAEKELVSEEMRLVYVA 858
Cdd:cd18809 36 MTIHKSQGSEFDRVIV-----------------------------------------------VLPTSHPMLSRGLLYTA 68
|
90
....*....|..
gi 581790339 859 LTRAKEQLYLIG 870
Cdd:cd18809 69 LTRARKLLTLVG 80
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
371-472 |
5.10e-04 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 41.32 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581790339 371 HFALQILTNEDGSPSEI-AESYRQH----FQEILVDEYQDTNRVQekiLSCIKTGDEHNGNLFMVGDVKQSIYKFRQADP 445
Cdd:cd17914 18 KIVAALMQNKNGEPGRIlLVTPTNKaaaqLDNILVDEAAQILEPE---TSRLIDLALDQGRVILVGDHDQLGPVWRGAVL 94
|
90 100
....*....|....*....|....*...
gi 581790339 446 S-LFIEKYQRFTIDGDGTgRRIDLSQNF 472
Cdd:cd17914 95 AkICNEQSLFTRLVRLGV-SLIRLQVQY 121
|
|
| |
