NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|581585566|gb|EVP92518|]
View 

accessory regulator protein A [Staphylococcus aureus M1369]

Protein Classification

response regulator transcription factor( domain architecture ID 14434868)

response regulator transcription factor belonging to the LytTR/AlgR family with signal receiver (REC) and DNA-binding domains, that may be part of a two-component regulatory system

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 1.26e-43

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 143.53  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALaTDNPYEVLEQAKNMNDIGCYFLDIQLST-DINGIKLGSEIRKHD 79
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIEL-TGKTEELLEKIKERGKNGIYFLDIDIKMeEKNGLEVAQKIRKYD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 581585566  80 PVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PAELRTRIIDCLETAHTR 130
Cdd:cd17533   80 PYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 149-238 2.46e-17

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


:

Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 74.55  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  149 SNSVYVQYDDIMFFESstKSHRLIAHLDNRQIEFYGNLKEL-SQLD-DRFFRCHNSFVVNRHNIESIDSKER---IVYFK 223
Cdd:pfam04397   1 DRIILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLK 78

                          90
                  ....*....|....*
gi 581585566  224 NKEHCYASVRNVKKI 238
Cdd:pfam04397  79 NGEKIPVSRRYLKEL 93
 
Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 1.26e-43

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 143.53  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALaTDNPYEVLEQAKNMNDIGCYFLDIQLST-DINGIKLGSEIRKHD 79
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIEL-TGKTEELLEKIKERGKNGIYFLDIDIKMeEKNGLEVAQKIRKYD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 581585566  80 PVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PAELRTRIIDCLETAHTR 130
Cdd:cd17533   80 PYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-238 1.74e-42

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 143.80  E-value: 1.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKNYimieeKPMEIALATDNPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDP 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELLEE-HKPDLVFLDIQMP-GLDGFELARQLRELDP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  81 VGNIIFVTSHSELTYLTFvyKVAAMDFIFKD-DPAELRTRIIDCLETAHTRLQLLFKDNSVETIELKRGSNSVYVQYDDI 159
Cdd:COG3279   75 PPPIIFTTAYDEYALEAF--EVNAVDYLLKPiDEERLAKALEKAKERLEAKAAAEASPEEKDRIFVKSGGKLVKIPLDDI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566 160 MFFESStkSHRLIAHLDNRQIEFYGNLKEL-SQLD-DRFFRCHNSFVVNRHNIESIDSKER-IVYFKNKEHCYASVRNVK 236
Cdd:COG3279  153 LYIEAE--GNYVKIHTKDKKYLVRKTLKELeEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNgEVVLKNGEEIPVSRRYKK 230


                 ..
gi 581585566 237 KI 238
Cdd:COG3279  231 EF 232
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-120 2.70e-23

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 90.29  E-value: 2.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566    3 IFICEDDPKQRENMVTIIKNYIMIeekpmeiALATDNPYEVLEQAKNMnDIGCYFLDIQLStDINGIKLGSEIRKHDPVG 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV-------VAEADDGKEALELLKEE-RPDLILLDINMP-GMDGLELLKRIRRRDPTT 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 581585566   83 NIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPAELRTRI 120
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPfDPDELLAAI 110
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 149-238 2.46e-17

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 74.55  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  149 SNSVYVQYDDIMFFESstKSHRLIAHLDNRQIEFYGNLKEL-SQLD-DRFFRCHNSFVVNRHNIESIDSKER---IVYFK 223
Cdd:pfam04397   1 DRIILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLK 78

                          90
                  ....*....|....*
gi 581585566  224 NKEHCYASVRNVKKI 238
Cdd:pfam04397  79 NGEKIPVSRRYLKEL 93
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 1.20e-14

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 67.22  E-value: 1.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   152 VYVQYDDIMFFESStkSHRLIAHLDNRQIEFYGNLKELSQL--DDRFFRCHNSFVVNRHNIESIDSKER---IVYFKNKE 226
Cdd:smart00850   4 VLIPLDDILYIEAE--GNYVTVHTKDGTYLVRGTLKELEERldPDNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILKNGE 81

                           90
                   ....*....|..
gi 581585566   227 HCYASVRNVKKI 238
Cdd:smart00850  82 EVPVSRRYLKEL 93
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-62 1.96e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 38.32  E-value: 1.96e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581585566     1 MKIFICEDDPKQRENMVtiiknyIMIEEKPMEIALATDnPYEVLEQAKNmNDIGCYFLDIQL 62
Cdd:smart00448   1 MRILVVDDDPLLRELLK------ALLEKEGYEVDEATD-GEEALELLKE-EKPDLILLDIMM 54
PRK14084 PRK14084
DNA-binding response regulator;
1-214 1.23e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 38.96  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMvtiikNYIMIEEKPMEIALATDNPYEVLEQAKnMNDIGCYFLDIQLsTDINGIKLGSEIRKHDP 80
Cdd:PRK14084   1 MKALIVDDEPLARNEL-----TYLLNEIGGFEEINEAENVKETLEALL-INQYDIIFLDINL-MDESGIELAAKIQKMKE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  81 VGNIIFVTSHSelTYLTFVYKVAAMDFIFKddPAELRtRIIDCLETAhtRLQLLFKDNSVETIELKRGSNS--------- 151
Cdd:PRK14084  74 PPAIIFATAHD--QFAVKAFELNATDYILK--PFEQK-RIEQAVNKV--RATKAKDDNNASAIANDMSANFdqslpieid 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566 152 --VYV-QYDDIMFFesSTKSHRLIAHLDNRQIEFYGNL----KELSqlDDRFFRCHNSFVVNRHNIESID 214
Cdd:PRK14084 147 dkIHMlNQQDIIAI--GVHNGITTIHTTNHKYETTEPLnryeKRLN--PTYFIRIHRSYIINKKHIKEVE 212
 
Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 1.26e-43

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 143.53  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALaTDNPYEVLEQAKNMNDIGCYFLDIQLST-DINGIKLGSEIRKHD 79
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIEL-TGKTEELLEKIKERGKNGIYFLDIDIKMeEKNGLEVAQKIRKYD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 581585566  80 PVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PAELRTRIIDCLETAHTR 130
Cdd:cd17533   80 PYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-238 1.74e-42

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 143.80  E-value: 1.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKNYimieeKPMEIALATDNPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDP 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELLEE-HKPDLVFLDIQMP-GLDGFELARQLRELDP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  81 VGNIIFVTSHSELTYLTFvyKVAAMDFIFKD-DPAELRTRIIDCLETAHTRLQLLFKDNSVETIELKRGSNSVYVQYDDI 159
Cdd:COG3279   75 PPPIIFTTAYDEYALEAF--EVNAVDYLLKPiDEERLAKALEKAKERLEAKAAAEASPEEKDRIFVKSGGKLVKIPLDDI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566 160 MFFESStkSHRLIAHLDNRQIEFYGNLKEL-SQLD-DRFFRCHNSFVVNRHNIESIDSKER-IVYFKNKEHCYASVRNVK 236
Cdd:COG3279  153 LYIEAE--GNYVKIHTKDKKYLVRKTLKELeEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNgEVVLKNGEEIPVSRRYKK 230


                 ..
gi 581585566 237 KI 238
Cdd:COG3279  231 EF 232
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-120 2.70e-23

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 90.29  E-value: 2.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566    3 IFICEDDPKQRENMVTIIKNYIMIeekpmeiALATDNPYEVLEQAKNMnDIGCYFLDIQLStDINGIKLGSEIRKHDPVG 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV-------VAEADDGKEALELLKEE-RPDLILLDINMP-GMDGLELLKRIRRRDPTT 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 581585566   83 NIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPAELRTRI 120
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPfDPDELLAAI 110
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 149-238 2.46e-17

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 74.55  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  149 SNSVYVQYDDIMFFESstKSHRLIAHLDNRQIEFYGNLKEL-SQLD-DRFFRCHNSFVVNRHNIESIDSKER---IVYFK 223
Cdd:pfam04397   1 DRIILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLK 78

                          90
                  ....*....|....*
gi 581585566  224 NKEHCYASVRNVKKI 238
Cdd:pfam04397  79 NGEKIPVSRRYLKEL 93
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 1.20e-14

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 67.22  E-value: 1.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   152 VYVQYDDIMFFESStkSHRLIAHLDNRQIEFYGNLKELSQL--DDRFFRCHNSFVVNRHNIESIDSKER---IVYFKNKE 226
Cdd:smart00850   4 VLIPLDDILYIEAE--GNYVTVHTKDGTYLVRGTLKELEERldPDNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILKNGE 81

                           90
                   ....*....|..
gi 581585566   227 HCYASVRNVKKI 238
Cdd:smart00850  82 EVPVSRRYLKEL 93
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-110 1.15e-09

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 54.01  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   2 KIFICEDDPKQRENMVTIIKnyimiEEKPMEIALATDNPYEVLEQAKNMN-DIgcYFLDIQLStDINGIKLGSEIRKHDP 80
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILE-----WEAGFEVVGEAENGEEALELLEEHKpDL--VITDINMP-GMDGLELLEAIRELDP 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 581585566  81 VGNIIFVTSHSELTYLTFVYKVAAMDFIFK 110
Cdd:COG4753   73 DTKIIILSGYSDFEYAQEAIKLGADDYLLK 102
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-120 1.40e-09

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 55.69  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQREnmvtIIKNyiMIEEKPMEIALATDnPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDP 80
Cdd:COG3706    2 ARILVVDDDPTNRK----LLRR--LLEAAGYEVVEAAD-GEEALELLQE-HRPDLILLDLEMP-DMDGLELCRRLRADPR 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 581585566  81 VGN--IIFVTSHSELTYLTFVYKVAAMDFIFKD-DPAELRTRI 120
Cdd:COG3706   73 TADipIIFLTALDDEEDRARALEAGADDYLTKPfDPEELLARV 115
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-129 6.27e-08

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 49.97  E-value: 6.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQREnmvtIIKNYIMIEEKPMEIALATDnpyevLEQAKNM---NDIGCYFLDIQLStDINGIKLGSEIRK 77
Cdd:COG4565    4 IRVLIVEDDPMVAE----LLRRYLERLPGFEVVGVASS-----GEEALALlaeHRPDLILLDIYLP-DGDGLELLRELRA 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 581585566  78 HDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFK-DDPAELRTRIIDCLETAHT 129
Cdd:COG4565   74 RGPDVDVIVITAARDPETVREALRAGVVDYLIKpFTFERLREALERYLEYRRL 126
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-133 1.37e-07

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 51.50  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVtiiknyIMIEEKPMEIALATDnPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDP 80
Cdd:COG2204    3 ARILVVDDDPDIRRLLK------ELLERAGYEVETAAS-GEEALALLRE-EPPDLVLLDLRMP-GMDGLELLRELRALDP 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 581585566  81 VGNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPAELRTRIIDCLETAHTRLQL 133
Cdd:COG2204   74 DLPVILLTGYGDVETAVEAIKAGAFDYLTKPfDLEELLAAVERALERRRLRREN 127
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-110 5.64e-07

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 46.45  E-value: 5.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   5 ICEDDPKQRENMVTIIknyimiEEKPMEIALAtDNPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDPVGNI 84
Cdd:cd00156    2 IVDDDPAIRELLKSLL------EREGYEVDTA-ADGEEALELLRE-ERPDLVLLDLMMP-GMDGLELLRKLRELPPDIPV 72

                         90       100
                 ....*....|....*....|....*.
gi 581585566  85 IFVTSHSELTYLTFVYKVAAMDFIFK 110
Cdd:cd00156   73 IVLTAKADEEDAVRALELGADDYLVK 98
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-133 7.37e-07

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 48.62  E-value: 7.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMVTIIKN-YIMIeekpmeiaLATDNPYEVLEQAKNmNDIGCYFLDIQLsTDINGIKLGSEIRKHD 79
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTlGYDV--------VTAESGEEALELLLE-APPDLILLDVRM-PGMDGFELLRLLRADP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 581585566  80 PVGNI--IFVTSHSELTYLTFVYKVAAMDFIFK-DDPAELRTRIIDCLETAHTRLQL 133
Cdd:COG3437   77 STRDIpvIFLTALADPEDRERALEAGADDYLTKpFDPEELLARVRNALELRRLQREL 133
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-128 2.36e-06

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 45.20  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   3 IFICEDDPKQRENMVTIIknyimIEEKPMEIALATDNPYEVLEQAKNmNDIGCYFLDIQLStDINGIKLGSEIRKHDPVG 82
Cdd:cd17535    1 VLIVDDHPLVREGLRRLL-----ESEPDIEVVGEAADGEEALALLRE-LRPDVVLMDLSMP-GMDGIEALRRLRRRYPDL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 581585566  83 NIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAElrtRIIDCLETAH 128
Cdd:cd17535   74 KVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPE---ELIEAIRAVA 116
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-95 1.01e-05

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 43.48  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   3 IFICEDDPKQRENMVTIIKNyimiEEKPMEIALATDNPYEVLEQAKNMN-DIgcyfldiqLSTDI-----NGIKLGSEIR 76
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDW----EELGFEVVGEAENGEEALELIEEHKpDI--------VITDIrmpgmDGLELIEKIR 68

                         90
                 ....*....|....*....
gi 581585566  77 KHDPVGNIIFVTSHSELTY 95
Cdd:cd17536   69 ELYPDIKIIILSGYDDFEY 87
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-132 4.34e-05

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 41.75  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   3 IFICEDDPKQRENMVtiiknyIMIEEKP-MEIALATDNPYEVLEQAkNMNDIGCYFLDIQLStDINGIKLGSEIRKHDPV 81
Cdd:cd17532    1 ALIVDDEPLAREELR------YLLEEHPdIEIVGEAENGEEALEAI-EELKPDVVFLDIQMP-GLDGLELAKKLSKLAKP 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 581585566  82 GNIIFVTSHSEltYLTFVYKVAAMDFIFKddPAElRTRIIDCLETAHTRLQ 132
Cdd:cd17532   73 PLIVFVTAYDE--YAVEAFELNAVDYLLK--PFS-EERLAEALAKLRKRLS 118
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-92 1.48e-04

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 40.08  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPkqrenmvtIIKNYI--MIEEKPMEIALATDNPYEVLEQAKNMN-DIgcYFLDIQLSTDINGIKLGSEIRK 77
Cdd:cd17534    1 KKILIVEDEA--------IIALDLkeILESLGYEVVGIADSGEEAIELAEENKpDL--ILMDINLKGDMDGIEAAREIRE 70

                         90
                 ....*....|....*
gi 581585566  78 HDPVgNIIFVTSHSE 92
Cdd:cd17534   71 KFDI-PVIFLTAYSD 84
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-62 1.96e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 38.32  E-value: 1.96e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 581585566     1 MKIFICEDDPKQRENMVtiiknyIMIEEKPMEIALATDnPYEVLEQAKNmNDIGCYFLDIQL 62
Cdd:smart00448   1 MRILVVDDDPLLRELLK------ALLEKEGYEVDEATD-GEEALELLKE-EKPDLILLDIMM 54
PRK14084 PRK14084
DNA-binding response regulator;
1-214 1.23e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 38.96  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   1 MKIFICEDDPKQRENMvtiikNYIMIEEKPMEIALATDNPYEVLEQAKnMNDIGCYFLDIQLsTDINGIKLGSEIRKHDP 80
Cdd:PRK14084   1 MKALIVDDEPLARNEL-----TYLLNEIGGFEEINEAENVKETLEALL-INQYDIIFLDINL-MDESGIELAAKIQKMKE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566  81 VGNIIFVTSHSelTYLTFVYKVAAMDFIFKddPAELRtRIIDCLETAhtRLQLLFKDNSVETIELKRGSNS--------- 151
Cdd:PRK14084  74 PPAIIFATAHD--QFAVKAFELNATDYILK--PFEQK-RIEQAVNKV--RATKAKDDNNASAIANDMSANFdqslpieid 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566 152 --VYV-QYDDIMFFesSTKSHRLIAHLDNRQIEFYGNL----KELSqlDDRFFRCHNSFVVNRHNIESID 214
Cdd:PRK14084 147 dkIHMlNQQDIIAI--GVHNGITTIHTTNHKYETTEPLnryeKRLN--PTYFIRIHRSYIINKKHIKEVE 212
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 2-93 4.81e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 35.56  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   2 KIFICEDDPKQRENMVTIIK--NYIMIEekpmeialaTDNPYEVLEQAKNMNDIGCYFLDIQLStDINGIKLGSEIRKHD 79
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKkaGYAVTE---------AESGAEALEKLQQGKDIDIVVTDIVMP-EMDGIELAREARKID 70

                         90
                 ....*....|....
gi 581585566  80 PVGNIIFVTSHSEL 93
Cdd:cd18160   71 PDVKILFISGGAAA 84
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 3-115 8.72e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 35.33  E-value: 8.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581585566   3 IFICEDDPKQRENMVTIIKnyimiEEKPMEIALATDNPYEVLEQAKNMN-DIGcyFLDIQLStDINGIKLGSEIRKHDPV 81
Cdd:cd19930    1 VLIAEDQEMVRGALAALLE-----LEDDLEVVAQASNGQEALRLVLKHSpDVA--ILDIEMP-GRTGLEVAAELREELPD 72

                         90       100       110
                 ....*....|....*....|....*....|....
gi 581585566  82 GNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAE 115
Cdd:cd19930   73 TKVLIVTTFGRPGYFRRALAAGVDGYVLKDRPIE 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH