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Conserved domains on  [gi|581499472|gb|EVP08158|]
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Na(+)/H(+) antiporter subunit E1 [Staphylococcus aureus M1094]

Protein Classification

Na+/H+ antiporter subunit E( domain architecture ID 10017548)

Na+/H+ antiporter subunit E is part of a Na+/H+ prokaryotic antiporter complex that consists of seven subunits (MrpABCDEFG) and is involved in Na+ execretion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 15-158 3.89e-67

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 130017  Cd Length: 144  Bit Score: 200.45  E-value: 3.89e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   15 WLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGFFVYH 94
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPARSRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGFMTVS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 581499472   95 TDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:TIGR00942  81 TDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDISNEELWRETITRSYEKDLKEIFE 144
 
Name Accession Description Interval E-value
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 15-158 3.89e-67

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 200.45  E-value: 3.89e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   15 WLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGFFVYH 94
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPARSRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGFMTVS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 581499472   95 TDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:TIGR00942  81 TDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDISNEELWRETITRSYEKDLKEIFE 144
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
1-158 1.41e-66

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 199.69  E-value: 1.41e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   1 MAVQLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIII 80
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLLPARFYLRRIYKLIKLVPIFLKELIKANIDVAKIVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 581499472  81 KPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:PRK12651  81 KPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRKKLYIHAIDVKDKEEEIREIKDSFEKILLEVFE 158
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
4-158 1.44e-49

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 156.48  E-value: 1.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   4 QLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGR-FYVITLYRIIKLVIIFLIELIKANFDVLKIIIKP 82
Cdd:COG1863    7 HLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRlPYLRRPLRLLRLLLYFLWDIVVANIDVARRVLRP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581499472  83 SIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:COG1863   87 RLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRRTLYVHALDVDDPEALIEEIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 8-156 7.97e-48

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 151.85  E-value: 7.97e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472    8 NFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVIT-LYRIIKLVIIFLIELIKANFDVLKIIIKPSIKN 86
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPPRRpPLGLLRLLLYFLWEIVKANIQVARLVLRPKPPI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   87 EPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREV 156
Cdd:pfam01899  81 RPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRRVLYVHVLDVDDEEAARREIKGRLERRLLEI 150
 
Name Accession Description Interval E-value
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 15-158 3.89e-67

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 200.45  E-value: 3.89e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   15 WLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGFFVYH 94
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPARSRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGFMTVS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 581499472   95 TDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:TIGR00942  81 TDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDISNEELWRETITRSYEKDLKEIFE 144
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
1-158 1.41e-66

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 199.69  E-value: 1.41e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   1 MAVQLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIII 80
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLLPARFYLRRIYKLIKLVPIFLKELIKANIDVAKIVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 581499472  81 KPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:PRK12651  81 KPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRKKLYIHAIDVKDKEEEIREIKDSFEKILLEVFE 158
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
4-158 1.44e-49

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 156.48  E-value: 1.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   4 QLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGR-FYVITLYRIIKLVIIFLIELIKANFDVLKIIIKP 82
Cdd:COG1863    7 HLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRlPYLRRPLRLLRLLLYFLWDIVVANIDVARRVLRP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581499472  83 SIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGE 158
Cdd:COG1863   87 RLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRRTLYVHALDVDDPEALIEEIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 8-156 7.97e-48

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 151.85  E-value: 7.97e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472    8 NFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVIT-LYRIIKLVIIFLIELIKANFDVLKIIIKPSIKN 86
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPPRRpPLGLLRLLLYFLWEIVKANIQVARLVLRPKPPI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   87 EPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREV 156
Cdd:pfam01899  81 RPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRRVLYVHVLDVDDEEAARREIKGRLERRLLEI 150
PRK08965 PRK08965
putative monovalent cation/H+ antiporter subunit E; Reviewed
 1-156 3.56e-43

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181598  Cd Length: 162  Bit Score: 140.30  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   1 MAVQLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIII 80
Cdd:PRK08965   5 LLPQPLLSLWLALVWLLLNGSFSLGNLLLGLLLGLLIPLLLALLVPLEGRLRRPLALLRLLLVVLYDLVVSNIQVAWLIL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581499472  81 KPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREV 156
Cdd:PRK08965  85 RPGPRPRPGFVAVPLRLRSDLALTLLANIITLTPGTVVVEISRDRRTLYVHVLDLDDPEALIREIKQRYERLLMEI 160
PRK08383 PRK08383
putative monovalent cation/H+ antiporter subunit E; Reviewed
 7-158 7.10e-15

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181407  Cd Length: 168  Bit Score: 67.91  E-value: 7.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472   7 LNFIIAVFWLFV--------TNS--YTTNNFVLGFIFGLVLVYLLHRVLPGRFY-----VITLYRIIKLVIIFLIELIKA 71
Cdd:PRK08383   1 MSFITAFIWSYVlwlvltagSKGllWSPEELIAGLIFAAIVGYATRNIIGEKATrflnpIRWLLFIAYAFGPLFWGMVKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  72 NFDVLKIIIKPSIKnePGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVES---IKTS 148
Cdd:PRK08383  81 NLDVAYRVITGKIR--PGIVKVPVDLENDAQYTILSNSITLTPGTLTIEACPEEKALYVHWINVPEGLEKPESsepVSGP 158

                        170
                 ....*....|
gi 581499472 149 LEKIVREVGE 158
Cdd:PRK08383 159 FEKWARRLGE 168
PRK12596 PRK12596
putative monovalent cation/H+ antiporter subunit E; Reviewed
 11-156 2.11e-14

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 105779  Cd Length: 171  Bit Score: 66.92  E-value: 2.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  11 IAVFWLFVtNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGF 90
Cdd:PRK12596  14 LVLFWLLL-NSFTRAQFILGLVIAFGACRVMMALEPQKNHIRSPRMMIWLLYAASIDVLRSNIAVVRLILSPGRQRHPGF 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 581499472  91 FVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREV 156
Cdd:PRK12596  93 VVIPLELQNRTALAVLACMITASPGTAWVDYNAARGILTIHVLDLEDAETWRHLIKERYERPLIEI 158
PRK08382 PRK08382
putative monovalent cation/H+ antiporter subunit E; Reviewed
 10-156 2.75e-12

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 169415  Cd Length: 201  Bit Score: 61.73  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  10 IIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPG----------RFYVITLYRIIKLVIIFLIELIKANFDVLKII 79
Cdd:PRK08382  41 ILLAFWVIISGDLSPRGLILGALTTLIIASYMRDFLTEdirrsghllwKILYFALIYLPQYLIIMAFRLLESNLKVAKHV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  80 IKPSIknEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSD--DRTKIYIHAIDFST--KEQEVESIKTSLEKIVRE 155
Cdd:PRK08382 121 IFMDI--NPGIVKIKTDLHSDTGITILANSITLTPGTLTLDVVKklGETYLYVHWIDVETlnREKAGEKIKGDIEEWLKK 198


                 .
gi 581499472 156 V 156
Cdd:PRK08382 199 I 199
PRK12652 PRK12652
monovalent cation/H+ antiporter subunit E;
14-156 3.40e-10

monovalent cation/H+ antiporter subunit E;


Pssm-ID: 237160 [Multi-domain]  Cd Length: 357  Bit Score: 57.07  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  14 FWLFVTNSYTTNNFVLGFIFGLVLVYLLHRV----------LPGRfyvitLYRIIKLVIIFLIELIKANFDVLKIIIKPS 83
Cdd:PRK12652 179 FYLLLGDPLYWFDLLTGAVTALIVAVLLAHVtfsrppslrrTPLR-----VLRFLLYVPYLLWEIVKANVAIAYVILHPS 253

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 581499472  84 IKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRtkIYIHAIDFSTKEqevESIKTSLEKIVREV 156
Cdd:PRK12652 254 LPIDPTMVRVRAAVRSGLPLTTLANSITLTPGTLTVDVDDRH--LLVHSLTPSARE---DLFDGGLERAVRFV 321
PRK12654 PRK12654
monovalent cation/H+ antiporter subunit E;
62-159 5.45e-07

monovalent cation/H+ antiporter subunit E;


Pssm-ID: 237161  Cd Length: 151  Bit Score: 46.45  E-value: 5.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  62 IIFLI-ELIKANFDVLKIIIKPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTK-----IYIHAIDF 135
Cdd:PRK12654   8 APWLIgQIFVAGFSLIKDAFKGDKNFNPVVVRYPLRVTKDWQITALAASITATPGTLSLGLREPRKPgdpriLLVQAVFG 87

                         90       100
                 ....*....|....*....|....
gi 581499472 136 STKEQEVESIKTSLEKIVREVGEI 159
Cdd:PRK12654  88 SDPVSVLADIADMEERLAPSVKDI 111
PRK06279 PRK06279
putative monovalent cation/H+ antiporter subunit E; Reviewed
 54-139 9.67e-06

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180506 [Multi-domain]  Cd Length: 100  Bit Score: 41.96  E-value: 9.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  54 LYRIIKLVIIFLIELIKANFDVLKIIIKPSIknEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAI 133
Cdd:PRK06279   3 LLYGIGYLIVLIKAIIEAWIDVVKRSLNGKI--DPEVIEIETEINRPVGQVLLANSITLTPGTLTIDLDSEERILKVASI 80


                 ....*.
gi 581499472 134 DFSTKE 139
Cdd:PRK06279  81 SPRSRD 86
PRK06580 PRK06580
putative monovalent cation/H+ antiporter subunit E; Reviewed
 58-137 3.35e-04

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180628  Cd Length: 103  Bit Score: 37.92  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581499472  58 IKLVIIF---LIELIKANFDVLKIIIKPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDrtKIYIHAID 134
Cdd:PRK06580   7 IKFILYFpwlLLEIWKSAFSVIKIIWQRKIGIEPVFEWVDAEGLEEIGEIIYGNSITLTPGTVTLDINNN--MLLVHALN 84


                 ...
gi 581499472 135 FST 137
Cdd:PRK06580  85 KSS 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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