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Conserved domains on  [gi|581430346|gb|EVO40543|]
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MarR family transcriptional regulator [Staphylococcus aureus M1048]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-132 1.20e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 74.24  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581430346   1 MSTNKNDYEHMLFY---FAYKTFITTADEIIEKYGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQG 77
Cdd:COG1846    1 MSDEPDPAEERLGLllrRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 581430346  78 LIIEKVLETDRRVKKLYSTDKGDQLIAELNKAQDELLQNIYQQVGSDWYDVMEAL 132
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRL 135
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-132 1.20e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 74.24  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581430346   1 MSTNKNDYEHMLFY---FAYKTFITTADEIIEKYGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQG 77
Cdd:COG1846    1 MSDEPDPAEERLGLllrRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 581430346  78 LIIEKVLETDRRVKKLYSTDKGDQLIAELNKAQDELLQNIYQQVGSDWYDVMEAL 132
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRL 135
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 1.45e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 61.45  E-value: 1.45e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 581430346   31 YGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQGLIIEKVLETDRR 89
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-120 1.25e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 57.60  E-value: 1.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581430346    26 EIIEKYGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQGLIIEKVLETDRRVKKLYSTDKGDQLIAE 105
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90
                   ....*....|....*
gi 581430346   106 LNKAQDELLQNIYQQ 120
Cdd:smart00347  81 LLEARSETLAELLAG 95
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 69-120 4.78e-06

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 43.45  E-value: 4.78e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 581430346  69 TLQKLKEQGLIIEKVLETDRRVKKLYSTDKGDQLIAELN----KAQDELLQNIYQQ 120
Cdd:PRK03573  66 TLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEavinKTRAEILHGISAE 121
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-132 1.20e-17

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 74.24  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581430346   1 MSTNKNDYEHMLFY---FAYKTFITTADEIIEKYGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQG 77
Cdd:COG1846    1 MSDEPDPAEERLGLllrRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 581430346  78 LIIEKVLETDRRVKKLYSTDKGDQLIAELNKAQDELLQNIYQQVGSDWYDVMEAL 132
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRL 135
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 1.45e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 61.45  E-value: 1.45e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 581430346   31 YGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQGLIIEKVLETDRR 89
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-120 1.25e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 57.60  E-value: 1.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 581430346    26 EIIEKYGMSRQHHRFLFFINKLPGITIKSLLEILEISKQGSHATLQKLKEQGLIIEKVLETDRRVKKLYSTDKGDQLIAE 105
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90
                   ....*....|....*
gi 581430346   106 LNKAQDELLQNIYQQ 120
Cdd:smart00347  81 LLEARSETLAELLAG 95
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 69-120 4.78e-06

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 43.45  E-value: 4.78e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 581430346  69 TLQKLKEQGLIIEKVLETDRRVKKLYSTDKGDQLIAELN----KAQDELLQNIYQQ 120
Cdd:PRK03573  66 TLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEavinKTRAEILHGISAE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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