|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
2-446 |
0e+00 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 788.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 2 SHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYDH 81
Cdd:PRK00451 1 GMPYIPHTEEDIREMLDAIGVKSIDELFADIPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEEYPSFLGAGAYDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 82 YAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVS 161
Cdd:PRK00451 81 YIPAVVDHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 162 KGLHYQALQVLHTYAKTRkEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIQSFIEDKKALFIVY 241
Cdd:PRK00451 161 GAVHPEYREVLKTYLKGQ-GIEVVEVPYEDGVTDLEALEAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 242 ANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIR 321
Cdd:PRK00451 240 VDPVSLGLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 322 RDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGF-EVLDGTSFNEFVVKFDKPIQQVNEE 400
Cdd:PRK00451 320 REKATSNICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGvELFDGPFFNEFVVRLPKPAEEVNEA 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 580096370 401 LVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGEL 446
Cdd:PRK00451 400 LLEKGILGGYDLGRYYPELGNHLLVCVTEKRTKEDIDALVAALGEV 445
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
1-445 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 703.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 1 MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNitkETHTSFLGAGVYD 80
Cdd:COG0403 3 FAMRYIPPTEEDRAEMLAAIGVDSLDELFDDIPAEIRLKRPLDLPEALSEAELLRHLRALAAKN---KVLTSFIGAGYYD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 81 HYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKK-NKIV 159
Cdd:COG0403 80 HYVPAVVRNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 160 VSKGLHYQALQVLHTYAKTRkEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIQSFIEDKKALFI 239
Cdd:COG0403 160 VSEDVHPQTRAVLKTYAEPL-GIEVVEVPDEDGVTDLEALKALLDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 240 VYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQH 319
Cdd:COG0403 239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 320 IRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVL-DGTSFNEFVVKFDKPIQQVN 398
Cdd:COG0403 319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLPKPAAEIN 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 580096370 399 EELVKYNIIGGFDLGVVSDdfkNHMLIAVTELRTKDEIDTFVEKAGE 445
Cdd:COG0403 399 AALLEKGILGGLNLRRVDD---DTLLVAVTETTTKEDIDALVEALAE 442
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
3-437 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 533.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 3 HRYIPLTEKDKQEMLQTIGAKSIGELFG-DVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNitkETHTSFLGAGVYDH 81
Cdd:pfam02347 1 DRHIGPSEKDQQEMLATLGYSSLDDLIGkAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKN---TVYRSFIGMGYYDT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 82 YAPSVVD-AMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKK--NKI 158
Cdd:pfam02347 78 ILPPVILrNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKkgKKF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 159 VVSKGLHYQALQVLHTYAKTRkEFEVVEIDL-DGTVTDLKkleaavddETAAVAVQYPNFYGSIEDLEKIQSFIEDKKAL 237
Cdd:pfam02347 158 VVDKDVHPQTLEVLKTRAKPF-GIEIVEVDYtEEGVTDLK--------DVFGVLVQYPNTDGRIEDYKELIELAHQRKSL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 238 FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQARE 317
Cdd:pfam02347 229 VVVAADLLALTLLKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTRE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 318 QHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQfIKKGFEVLDGTSFNEFVVKFDKPiqQV 397
Cdd:pfam02347 309 QHIRRDKATSNICTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKA-LKKLGHELVHKHFFDTLLIEVED--KA 385
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 580096370 398 NEELVKYNIIGGFDLGVVSDDfknHMLIAVTELRTKDEID 437
Cdd:pfam02347 386 VEEVLARAEARGINLRYVDLG---HVGIALDETVTKEDID 422
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
50-441 |
2.05e-176 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 499.07 E-value: 2.05e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 50 ETTLLRRLNRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMD 129
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILENEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 130 VANSSMYDGMTSFAEACILAFSQTK--KNKIVVSKGLHYQALQVLHTYAKTrKEFEVVEIDLDGTVT-DLKKLEAAVDDE 206
Cdd:cd00613 81 VANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEP-LGIEVVEVPSDEGGTvDLEALKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 207 TAAVAVQYPNFYGSIEDLekIQSFIE---DKKALFIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFA 283
Cdd:cd00613 160 VAALMVQYPNTLGVFEDL--IKEIADiahSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 284 TTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHA 363
Cdd:cd00613 238 VKKELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 580096370 364 NYAKQQFIKKGFEVL-DGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVE 441
Cdd:cd00613 318 NYLAKRLKEVGGVLPfNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAPTMYLPVDGTLMIEPTETETKEELDALLE 396
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
2-446 |
0e+00 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 788.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 2 SHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYDH 81
Cdd:PRK00451 1 GMPYIPHTEEDIREMLDAIGVKSIDELFADIPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEEYPSFLGAGAYDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 82 YAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVS 161
Cdd:PRK00451 81 YIPAVVDHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 162 KGLHYQALQVLHTYAKTRkEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIQSFIEDKKALFIVY 241
Cdd:PRK00451 161 GAVHPEYREVLKTYLKGQ-GIEVVEVPYEDGVTDLEALEAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 242 ANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIR 321
Cdd:PRK00451 240 VDPVSLGLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 322 RDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGF-EVLDGTSFNEFVVKFDKPIQQVNEE 400
Cdd:PRK00451 320 REKATSNICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGvELFDGPFFNEFVVRLPKPAEEVNEA 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 580096370 401 LVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGEL 446
Cdd:PRK00451 400 LLEKGILGGYDLGRYYPELGNHLLVCVTEKRTKEDIDALVAALGEV 445
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
1-445 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 703.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 1 MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNitkETHTSFLGAGVYD 80
Cdd:COG0403 3 FAMRYIPPTEEDRAEMLAAIGVDSLDELFDDIPAEIRLKRPLDLPEALSEAELLRHLRALAAKN---KVLTSFIGAGYYD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 81 HYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKK-NKIV 159
Cdd:COG0403 80 HYVPAVVRNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 160 VSKGLHYQALQVLHTYAKTRkEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIQSFIEDKKALFI 239
Cdd:COG0403 160 VSEDVHPQTRAVLKTYAEPL-GIEVVEVPDEDGVTDLEALKALLDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 240 VYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQH 319
Cdd:COG0403 239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 320 IRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVL-DGTSFNEFVVKFDKPIQQVN 398
Cdd:COG0403 319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLPKPAAEIN 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 580096370 399 EELVKYNIIGGFDLGVVSDdfkNHMLIAVTELRTKDEIDTFVEKAGE 445
Cdd:COG0403 399 AALLEKGILGGLNLRRVDD---DTLLVAVTETTTKEDIDALVEALAE 442
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
3-437 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 533.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 3 HRYIPLTEKDKQEMLQTIGAKSIGELFG-DVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNitkETHTSFLGAGVYDH 81
Cdd:pfam02347 1 DRHIGPSEKDQQEMLATLGYSSLDDLIGkAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKN---TVYRSFIGMGYYDT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 82 YAPSVVD-AMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKK--NKI 158
Cdd:pfam02347 78 ILPPVILrNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKkgKKF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 159 VVSKGLHYQALQVLHTYAKTRkEFEVVEIDL-DGTVTDLKkleaavddETAAVAVQYPNFYGSIEDLEKIQSFIEDKKAL 237
Cdd:pfam02347 158 VVDKDVHPQTLEVLKTRAKPF-GIEIVEVDYtEEGVTDLK--------DVFGVLVQYPNTDGRIEDYKELIELAHQRKSL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 238 FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQARE 317
Cdd:pfam02347 229 VVVAADLLALTLLKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTRE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 318 QHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQfIKKGFEVLDGTSFNEFVVKFDKPiqQV 397
Cdd:pfam02347 309 QHIRRDKATSNICTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKA-LKKLGHELVHKHFFDTLLIEVED--KA 385
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 580096370 398 NEELVKYNIIGGFDLGVVSDDfknHMLIAVTELRTKDEID 437
Cdd:pfam02347 386 VEEVLARAEARGINLRYVDLG---HVGIALDETVTKEDID 422
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
50-441 |
2.05e-176 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 499.07 E-value: 2.05e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 50 ETTLLRRLNRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMD 129
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILENEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 130 VANSSMYDGMTSFAEACILAFSQTK--KNKIVVSKGLHYQALQVLHTYAKTrKEFEVVEIDLDGTVT-DLKKLEAAVDDE 206
Cdd:cd00613 81 VANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEP-LGIEVVEVPSDEGGTvDLEALKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 207 TAAVAVQYPNFYGSIEDLekIQSFIE---DKKALFIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFA 283
Cdd:cd00613 160 VAALMVQYPNTLGVFEDL--IKEIADiahSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 284 TTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHA 363
Cdd:cd00613 238 VKKELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 580096370 364 NYAKQQFIKKGFEVL-DGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVE 441
Cdd:cd00613 318 NYLAKRLKEVGGVLPfNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAPTMYLPVDGTLMIEPTETETKEELDALLE 396
|
|
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
4-438 |
9.89e-85 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 279.73 E-value: 9.89e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 4 RYIPLTEKDKQEMLQTIGAKSIGELF-GDVPSDILLnRDLNIA---EGEAETTLLRRLNRIASKNitkETHTSFLGAGVY 79
Cdd:PLN02414 38 RHNSATPEEQKAMAEYCGFDSLDALIdATVPKSIRL-DSMKLSkydEGLTESQMLEHMKSLASKN---KVFKSYIGMGYY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 80 DHYAPSVV-DAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFS--QTKKN 156
Cdd:PLN02414 114 NTHVPPVIlRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNASLLDEGTAAAEAMAMCNNilKGKKK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 157 KIVVSKGLHYQALQVLhtyaKTRKEfevvEIDLDGTVTDLKKLEAAVDDeTAAVAVQYPNFYGSIEDLEKIQSFIEDKKA 236
Cdd:PLN02414 194 KFLIASNCHPQTIDVC----QTRAD----GLGLEVVVADEKDFDYSSGD-VCGVLVQYPATDGEVLDYAEFVKNAHANGV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 237 LFIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAR 316
Cdd:PLN02414 265 KVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSVDSSGKPALRMAMQTR 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 317 EQHIRRDKATSNICSNQALnaLASSIAMSAL--GKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPi 394
Cdd:PLN02414 345 EQHIRRDKATSNICTAQAL--LANMAAMYAVyhGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLPFFDTVKVKCSDA- 421
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 580096370 395 QQVNEELVKYNIiggfDLGVVSddfKNHMLIAVTELRTKDEIDT 438
Cdd:PLN02414 422 DAIADAAAKVGI----NLRVVD---ANTVTVSFDETTTLEDVDK 458
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
49-441 |
4.56e-10 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 61.20 E-value: 4.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 49 AETTLLRRLNRIASKNItkethtsflgaGVyDH-----------YAPSVVDAMISRSEFyTAYTPYQPE-ISQGELQAIF 116
Cdd:COG1003 30 SETEVLRHYTRLSQKNL-----------GL-DTgmiplgsctmkYNPKINEEPATLPGF-ANLHPFQPEeTVQGYLELMY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 117 EFQTLICELTDMDVAnsSM---------YDGMtsfaeACILAF----SQTKKNKIVV--S-----------KGlhyqalq 170
Cdd:COG1003 97 ELEEWLAEITGMDAV--SLqpnagaqgeYAGL-----LAIRAYhesrGEGHRNEILIpdSahgtnpasaamAG------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 171 vlhtyaktrkeFEVVEI--DLDGTVtDLKKLEAAVDDETAAVAVQYPNFYG----SIEDLEKIqsfIEDKKALfiVY--- 241
Cdd:COG1003 163 -----------FKVVVVksDEDGNV-DLEDLKAKVGDRTAALMLTNPSTHGvfeeDIKEICDI---VHEAGGL--VYydg 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 242 --ANPLaLGlLTPPGSFGADIV---VGDTqpFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDdegnrGFVLTlQAR 316
Cdd:COG1003 226 anLNAI-VG-LARPGDMGFDVChlnLHKT--FSTPHGGGGPGSGPVGVKEHLAPFLPGPPVVKDGD-----KYRLD-YDR 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 317 EQHIRRDKA---TSNICsnqaLNALAsSIAMsaLGKQGIY---DIAVQNiehANYAKQQfIKKGFEVL---DGTSFNEFV 387
Cdd:COG1003 296 PKSIGRSAAfygNAGVL----VRAYA-YIRM--MGAEGLReatEVAVLN---ANYLAAR-LKDHYPVLytgNGRCAHEFI 364
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 580096370 388 VKfDKPIQQvneelvkyniiggfDLGVVSDDFKN-------H-------------MLIAVTELRTKDEIDTFVE 441
Cdd:COG1003 365 LD-LRPLKK--------------ETGVTTLDIAKrlldygfHaptmyfplivpetLMIEPTESESKEELDRFID 423
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
82-261 |
6.22e-09 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 57.81 E-value: 6.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 82 YAPSVVDAMISRSEFyTAYTPYQPE-ISQGELQAIFEFQTLICELTDMD-VANSSM------YDGMtsfaeACILAF--- 150
Cdd:PRK04366 82 YNPKINEKVARLPGF-AELHPLQPEeTVQGALELMYELQEWLKEITGMDaVTLQPAagahgeLTGL-----LMIRAYhea 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 151 -SQTKKNKIVVS-------------KGlhyqalqvlhtyaktrkeFEVVEI--DLDGTVtDLKKLEAAVDDETAAVAVQY 214
Cdd:PRK04366 156 rGDTKRTEVIVPdsahgtnpasaamAG------------------FKVVEIpsNEDGLV-DLEALKAAVGEDTAALMLTN 216
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 580096370 215 PNFYGSIE-DLEKIQSFIEDKKALFivY---ANPLA-LGlLTPPGSFGADIV 261
Cdd:PRK04366 217 PNTLGLFErNILEIAEIVHEAGGLL--YydgANLNAiLG-KARPGDMGFDVV 265
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
118-262 |
1.06e-04 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 44.15 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 118 FQTLICELTDMD--VANSSmydGMTSFAEAcILAFSQTKKNkIVVSKGLhYQALQVLHTYAKTRKEFEVVEIDLDgtvtD 195
Cdd:pfam01053 52 LEERIAALEGGAaaLAFSS---GMAAITAA-ILALLKAGDH-IVATDDL-YGGTYRLFNKVLPRFGIEVTFVDTS----D 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 580096370 196 LKKLEAAVDDETAAVAVQYP-NFYGSIEDLEKIQSFIEDKKALFIVyANPLALGLLTPPGSFGADIVV 262
Cdd:pfam01053 122 PEDLEAAIKPNTKAVYLETPtNPLLKVVDIEAIAKLAKKHGILVVV-DNTFASPYLQRPLDLGADIVV 188
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
175-262 |
1.09e-04 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 44.12 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 175 YAKTRKEFEVVEIDLDGTVT-----DLKKLEAAVDDETAAVAVQYP-NFYGSIEDLEKIQSFIEDKKALFIVyANPLALG 248
Cdd:cd00614 89 YGGTYRLFERLLPKLGIEVTfvdpdDPEALEAAIKPETKLVYVESPtNPTLKVVDIEAIAELAHEHGALLVV-DNTFATP 167
|
90
....*....|....
gi 580096370 249 LLTPPGSFGADIVV 262
Cdd:cd00614 168 YLQRPLELGADIVV 181
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
170-262 |
2.11e-03 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 40.08 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 170 QVLHTYaktrKEF--EVVEIDLDgtvtDLKKLEAAVDDETAAVAVQ-YPNFYGSIEDLEKIQSFIEDKKALFIVyANPLA 246
Cdd:PRK05994 118 QFGHAF----KSFgwQVRWADAD----DPASFERAITPRTKAIFIEsIANPGGTVTDIAAIAEVAHRAGLPLIV-DNTLA 188
|
90
....*....|....*.
gi 580096370 247 LGLLTPPGSFGADIVV 262
Cdd:PRK05994 189 SPYLIRPIEHGADIVV 204
|
|
| PLN02651 |
PLN02651 |
cysteine desulfurase |
154-238 |
2.82e-03 |
|
cysteine desulfurase
Pssm-ID: 178257 [Multi-domain] Cd Length: 364 Bit Score: 39.64 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 580096370 154 KKNKIVVSKGLHYQAlqVL-HTYAKTRKEFEV--VEIDLDGTVtDLKKLEAAVDDETAAVAVQYPNF-YGSIEDLEKIQS 229
Cdd:PLN02651 86 DKKKHVITTQTEHKC--VLdSCRHLQQEGFEVtyLPVKSDGLV-DLDELAAAIRPDTALVSVMAVNNeIGVIQPVEEIGE 162
|
....*....
gi 580096370 230 FIEDKKALF 238
Cdd:PLN02651 163 LCREKKVLF 171
|
|
| |
