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Conserved domains on  [gi|579917258|gb|EUZ54864|]
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phage protein [Staphylococcus aureus M0471]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PemK_toxin super family cl46550
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 46-98 3.82e-04

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


The actual alignment was detected with superfamily member COG2337:

Pssm-ID: 480890  Cd Length: 111  Bit Score: 39.00  E-value: 3.82e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 579917258  46 KFKQGEIVFVDFGINVNKEFSNSHFAIVMNKNDSN-TEDIVNVIPLSSKENKKY 98
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNrYSPTVIVAPITSNIRKGY 54
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 46-98 3.82e-04

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 39.00  E-value: 3.82e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 579917258  46 KFKQGEIVFVDFGINVNKEFSNSHFAIVMNKNDSN-TEDIVNVIPLSSKENKKY 98
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNrYSPTVIVAPITSNIRKGY 54
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 48-97 4.49e-04

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 38.76  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 579917258   48 KQGEIVFVDFGINVNKEFSNSHFAIV-----MNKNDSNTediVNVIPLSSKENKK 97
Cdd:pfam02452   1 KRGDIVLVDLDPTVGSEQGKRRPALVvsndaFNELSTPT---VIVAPITSKLKGK 52
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 46-98 3.82e-04

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 39.00  E-value: 3.82e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 579917258  46 KFKQGEIVFVDFGINVNKEFSNSHFAIVMNKNDSN-TEDIVNVIPLSSKENKKY 98
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNrYSPTVIVAPITSNIRKGY 54
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 48-97 4.49e-04

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 38.76  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 579917258   48 KQGEIVFVDFGINVNKEFSNSHFAIV-----MNKNDSNTediVNVIPLSSKENKK 97
Cdd:pfam02452   1 KRGDIVLVDLDPTVGSEQGKRRPALVvsndaFNELSTPT---VIVAPITSKLKGK 52
YifN COG3692
Uncharacterized conserved protein YifN, PemK superfamily [Function unknown];
43-119 5.30e-04

Uncharacterized conserved protein YifN, PemK superfamily [Function unknown];


Pssm-ID: 442907  Cd Length: 132  Bit Score: 38.81  E-value: 5.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 579917258  43 FYPKfkQGEIVFVDFGI-NVNKEFSNSHFAIVMNKNDSNTEDIVNVIPLSSKENKKYLKMNFDLKWEYYLRLFLNLIS 119
Cdd:COG3692    5 FHPK--VGEILMCDFSTgFVPPEMVKRRPVVVISPKLRNRPGLCTVVPLSTTPPRPVEPYHYRLPRNPLPDKFDNRPS 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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