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Conserved domains on  [gi|579673746|gb|EUX18132|]
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polysaccharide extrusion protein [Staphylococcus aureus M0321]

Protein Classification

MATE family efflux transporter( domain architecture ID 8282)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_like super family cl09326
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 9-395 1.53e-33

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


The actual alignment was detected with superfamily member cd13128:

Pssm-ID: 447704 [Multi-domain]  Cd Length: 402  Bit Score: 130.74  E-value: 1.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   9 NIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKsvNDKRQLSQQFWDIFV 88
Cdd:cd13128    4 NSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIAR--YRKEKIREIISTSLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  89 SKLFLALTVFAMYMVVITIFIDDYY---LIFLLQGIYIIGAALDISWF--YAGTEKFKIPSLSNIVASGIVLSVVVIFVK 163
Cdd:cd13128   82 LKLILGILALLLLFLFAFLIAFYDPelvLLLYILALSLPFSALNSLFRgiFQGFEKMKYIVIARIIESVLSLILALILVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 164 DQSDLSLYVFTIAIVTVLNQLPLFIYLKRYI---SFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLGLVGTYQQ 240
Cdd:cd13128  162 LGGGLIGFALAYLIASVLSAILLLYIYRKKIllpKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 241 VGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGEEFAS 320
Cdd:cd13128  242 VGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 579673746 321 TVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLI 395
Cdd:cd13128  322 AALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFI 395
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 9-395 1.53e-33

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 130.74  E-value: 1.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   9 NIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKsvNDKRQLSQQFWDIFV 88
Cdd:cd13128    4 NSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIAR--YRKEKIREIISTSLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  89 SKLFLALTVFAMYMVVITIFIDDYY---LIFLLQGIYIIGAALDISWF--YAGTEKFKIPSLSNIVASGIVLSVVVIFVK 163
Cdd:cd13128   82 LKLILGILALLLLFLFAFLIAFYDPelvLLLYILALSLPFSALNSLFRgiFQGFEKMKYIVIARIIESVLSLILALILVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 164 DQSDLSLYVFTIAIVTVLNQLPLFIYLKRYI---SFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLGLVGTYQQ 240
Cdd:cd13128  162 LGGGLIGFALAYLIASVLSAILLLYIYRKKIllpKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 241 VGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGEEFAS 320
Cdd:cd13128  242 VGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 579673746 321 TVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLI 395
Cdd:cd13128  322 AALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFI 395
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 5-398 9.42e-25

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 105.03  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   5 SLKENIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKsvNDKRQLSQQFW 84
Cdd:COG2244    3 KLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAE--YREEELRRLLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  85 DIFVSKLFLALTVFAMYMVVITIFIDDYYLIFLLQGIYIIGAALDISWFYA-------GTEKFKIPSLSNIVASGIVLSV 157
Cdd:COG2244   81 TALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAvllallrGLERFKLLALINILSSLLSLLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 158 VVIFVKDQSDLSLYVFtiaivtvlnqlplfiylkryisfvsvnwihvwqlfRSSLAYLLPNGQLNLYTSISCVVLGLVGT 237
Cdd:COG2244  161 ALLLALLGLGLWGLVL-----------------------------------KYSLPLLLSGLLGLLLTNLDRLLLGALLG 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 238 YQQVGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHS-LTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGE 316
Cdd:COG2244  206 PAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREeLRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGP 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 317 EFASTVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLIW 396
Cdd:COG2244  286 EYAEAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLL 364


                 ..
gi 579673746 397 RF 398
Cdd:COG2244  365 LL 366
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 6-272 4.17e-11

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 63.48  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746    6 LKENIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKSvNDKRQLSQQFWD 85
Cdd:pfam01943   1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKY-REKYELVSLYWL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   86 IFVSKLFLALTVFAMYMVVITIFIDDY----YLIFLLQGIYIIGAALDISWFYAGTEKFKIPSLSNIVASGIVLSVVVIF 161
Cdd:pfam01943  80 NALLVKLVLVLLFLLLPLIAAFLGLPElavlYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  162 VKDQSDLSLYVFTIAIVTVLNQLPLFIYLKRY--ISFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLGLVGTYQ 239
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKIfrPRFVFPSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAG 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 579673746  240 QVGIFSNAFNILTVAIIMINTF-DLVMIPRITKM 272
Cdd:pfam01943 240 AVGIYNAAYQLLVAIQGLLNPIvTAVLFPVFSKL 273
PRK10459 PRK10459
MOP flippase family protein;
222-471 1.13e-03

MOP flippase family protein;


Pssm-ID: 236697 [Multi-domain]  Cd Length: 492  Bit Score: 41.17  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 222 NLYTSISCVVLGLVGTYQQVGIFSNAFNILTVAIIMINtfdlvmiPRITKMS------IQQSHS-LTKTLANNMNIQLIL 294
Cdd:PRK10459 224 YLNTNIDTILIGRILGAEVLGGYNLAYNVATVPPMKIN-------PIITRVAfpvfakIQDDTEkLRVGFLKLLSVLGII 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 295 TIPMVFGLIAIMPSFYLWFFGEEFASTVPLMTILAIL----VLIIPLNMLisrqyLLIVNKIRLYNASITIGAVMNLVLC 370
Cdd:PRK10459 297 NFPLLLGLMVVSNNFVPLVFGEKWNSAIPILQLLCIVgllrSVGNPIGSL-----LLAKGRADLSFKWNVFKTFLFIPAI 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 371 LVLIYFYGIYGAAIARLITEFILLIWRFVDITKINVKLNIVSTIQ-----CVIAAVMMFIVLGVV---NHYLPPTMYAtL 442
Cdd:PRK10459 372 VIGGQLAGLIGVALGFLLVQIINTILSYFLMIKPVIGLSYRQYILsiwkpFYLSLPMLIVSYGLGlllKGHLALGMLL-A 450

                        250       260
                 ....*....|....*....|....*....
gi 579673746 443 LLIAIGIVVYLLLMMTMKNQYVWQILRHL 471
Cdd:PRK10459 451 VQVAAGVLAYLLMIVLSRHALVVEVKRQF 479
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 9-395 1.53e-33

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 130.74  E-value: 1.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   9 NIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKsvNDKRQLSQQFWDIFV 88
Cdd:cd13128    4 NSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIAR--YRKEKIREIISTSLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  89 SKLFLALTVFAMYMVVITIFIDDYY---LIFLLQGIYIIGAALDISWF--YAGTEKFKIPSLSNIVASGIVLSVVVIFVK 163
Cdd:cd13128   82 LKLILGILALLLLFLFAFLIAFYDPelvLLLYILALSLPFSALNSLFRgiFQGFEKMKYIVIARIIESVLSLILALILVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 164 DQSDLSLYVFTIAIVTVLNQLPLFIYLKRYI---SFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLGLVGTYQQ 240
Cdd:cd13128  162 LGGGLIGFALAYLIASVLSAILLLYIYRKKIllpKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 241 VGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGEEFAS 320
Cdd:cd13128  242 VGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 579673746 321 TVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLI 395
Cdd:cd13128  322 AALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFI 395
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 5-398 9.42e-25

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 105.03  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   5 SLKENIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKsvNDKRQLSQQFW 84
Cdd:COG2244    3 KLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAE--YREEELRRLLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  85 DIFVSKLFLALTVFAMYMVVITIFIDDYYLIFLLQGIYIIGAALDISWFYA-------GTEKFKIPSLSNIVASGIVLSV 157
Cdd:COG2244   81 TALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAvllallrGLERFKLLALINILSSLLSLLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 158 VVIFVKDQSDLSLYVFtiaivtvlnqlplfiylkryisfvsvnwihvwqlfRSSLAYLLPNGQLNLYTSISCVVLGLVGT 237
Cdd:COG2244  161 ALLLALLGLGLWGLVL-----------------------------------KYSLPLLLSGLLGLLLTNLDRLLLGALLG 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 238 YQQVGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHS-LTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGE 316
Cdd:COG2244  206 PAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREeLRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGP 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 317 EFASTVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLIW 396
Cdd:COG2244  286 EYAEAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLL 364


                 ..
gi 579673746 397 RF 398
Cdd:COG2244  365 LL 366
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 242-460 2.12e-12

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 69.03  E-value: 2.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 242 GIFS-NAFNILTVAIIMINTFDLVMIPRITK-MSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGEEFA 319
Cdd:COG5841  279 GILSgMAQPLVNLPTVLATALATSLVPAISEaFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEG 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 320 STvplmtILAILVLIIPLNML----------ISRQYLLIVNkirlynasITIGAVMNLVLCLVLIYFYGIYGAAIARLIT 389
Cdd:COG5841  359 GG-----ILAILAPSAIFLSLqqvttgilqgLGKQKIPVIN--------LLIGLLVKIILNYLLVPLFGIYGAALATVIG 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 390 EFILLIWRFVDITK-INVKLNIVST-IQCVIAAVMMFIVLGVVNHYLPPTMY--------ATLLLIAIGIVVYLLLMMTM 459
Cdd:COG5841  426 YLVAAILNLAALKKyTGFKLDLRRRlLKPLLASLIMGIVVLLLYRLLSLFLPesrlgallATLIAVLVGAIVYLLLLLKL 505


                 .
gi 579673746 460 K 460
Cdd:COG5841  506 G 506
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 6-272 4.17e-11

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 63.48  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746    6 LKENIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKSvNDKRQLSQQFWD 85
Cdd:pfam01943   1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKY-REKYELVSLYWL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   86 IFVSKLFLALTVFAMYMVVITIFIDDY----YLIFLLQGIYIIGAALDISWFYAGTEKFKIPSLSNIVASGIVLSVVVIF 161
Cdd:pfam01943  80 NALLVKLVLVLLFLLLPLIAAFLGLPElavlYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  162 VKDQSDLSLYVFTIAIVTVLNQLPLFIYLKRY--ISFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLGLVGTYQ 239
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKIfrPRFVFPSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAG 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 579673746  240 QVGIFSNAFNILTVAIIMINTF-DLVMIPRITKM 272
Cdd:pfam01943 240 AVGIYNAAYQLLVAIQGLLNPIvTAVLFPVFSKL 273
MATE_tuaB_like cd13127
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 9-404 5.60e-09

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240532 [Multi-domain]  Cd Length: 406  Bit Score: 57.88  E-value: 5.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746   9 NIIYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYfnrVIAKSVNDKRQLSQQFWDIFV 88
Cdd:cd13127    4 GAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSA---LIQRKDLTEEDLSTVFWLNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  89 SKLFLALTVFAmymvvITIFIDDYY-------------LIFLLQGIYIIGAALdiswfYAGTEKFKIPSLSNIVASGIVL 155
Cdd:cd13127   81 LGLLLYLLLFL-----LAPLIAAFYnepelipllrvlsLSFLLSGLGSVPRAL-----LQRELRFKKLAIIELISTLVSG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 156 SVVVIFVkdqsdLSLY-VFTIAIVTVLNQL---PLFIYLKRYISFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVV 231
Cdd:cd13127  151 VVAIVLA-----LLGFgVWALVAQQLVGALvstVLLWILSRWRPRLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLI 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 232 LGLVGTYQQVGIFSNAFNILTVAIIMINT-FDLVMIPRITKMSiQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFY 310
Cdd:cd13127  226 IGKFLGAAALGYYSRAYRLALLPVQNITGpITRVLFPALSRLQ-DDPERLRRAYLKALRLLALITFPLMVGLALLAEPLV 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 311 LWFFGEEFASTVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMnLVLCLVLIYFYGIYGAAIARLITE 390
Cdd:cd13127  305 LLLLGEKWLPAVPILQILALAGLFQPLSSLNG-SLLLALGRTDLLLKLGLIKAVL-TVLALLIGIPYGIIGVAIAYVIAS 382

                        410
                 ....*....|....
gi 579673746 391 FILLIWRFVDITKI 404
Cdd:cd13127  383 LLSFPLNLYLAGRL 396
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 324-460 3.62e-08

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 52.19  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  324 LMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLIWRFVDITK 403
Cdd:pfam14667   1 VLQILALSIIFLSLSTVLT-SILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRR 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 579673746  404 -INVKLNIVSTIQCVIAAVMMFIVLGVVNHYLP---PTMYATLLLIAIGIVVYLLLMMTMK 460
Cdd:pfam14667  80 yLGLRLLLRRLLKPLLAALVMGIVVYLLLLLLGlllGLALALLLAVLVGALVYLLLLLLLK 140
MATE_like_10 cd13125
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 11-395 3.60e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240530 [Multi-domain]  Cd Length: 409  Bit Score: 49.08  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  11 IYQGLYQLIRTMTPLITIPIISRAFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKSVNDKRQLSQQFWDIFVSK 90
Cdd:cd13125    4 SLSGISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDDEEKLARVWSTAFRIT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  91 LFLAL---TVFAMYMVVITIFI---DDYYLIFLLQGIYIIGAALD--ISWFYAGTEKFKIPSLSNIVASGIVLSVVVIFV 162
Cdd:cd13125   84 LILSIlggLLLLLFSKPLSSLLfgdIDYSWVFILLGLALPLFALNnlLLAILNGLKEIKRYALINIISSLIGLLVSVLLV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 163 KdQSDLSLYVFTIAIVTVLNQLPLFIYLKRYISFVSVNWIhvWQLFRSSLAYLLPNGQLNLYTSISCVV--------LGL 234
Cdd:cd13125  164 Y-FYGLKGALLALVLNQSLIFLVTLIYSRKQPWFKLKYLW--GRLDKDIIKKLLKFSLMALVSALSLPLsqiivrniLIR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 235 VGTYQQVGIFSNAFNILTVAIIMINT-FDLVMIPRITkmSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWF 313
Cdd:cd13125  241 QLGWEAAGYWQAVWKISDVYLGFITTaLSTYYLPRLS--AIKDNKELKREVNKQLKVILPLVAIGALLIYLLRDLIIQIL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 314 FGEEFASTVPLMTILAILVLIIPLNMLISrqYLLIV-NKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFI 392
Cdd:cd13125  319 FSEEFLPARELFLWQLIGDFFKIASWLLG--YILLAkGMTKLFIITEILFALLFVLLSLLFIPLFGLEGAGIAYAINYIL 396


                 ...
gi 579673746 393 LLI 395
Cdd:cd13125  397 YLI 399
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 242-403 1.76e-05

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 47.08  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 242 GIFS-NAFNILTVAIIMINTFDLVMIPRITK-MSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFYLWFFGEEFA 319
Cdd:cd13124  270 GILTgRAQPLVQLPTVIATALSTSLVPAISEaYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEG 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 320 StvPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLIWRFV 399
Cdd:cd13124  350 G--LILQILAPSILFLSLQQVTA-AILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLR 426


                 ....
gi 579673746 400 DITK 403
Cdd:cd13124  427 ALKK 430
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 250-460 5.03e-05

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 45.53  E-value: 5.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 250 ILTVAIIMintfdlVMIPRITKMSIQQSH-SLTKTLANNMNIQLILTIPMVFGLIAI-MPSFYLWFFGEEFASTVPLMTI 327
Cdd:COG0728  273 LFGVAIGT------ALLPRLSRAAAAGDLeEFRRTLSRGLRLVLLLTLPAAVGLIVLaEPIVRLLFERGAFTAEDTALTA 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 328 LAILVLIIPLNMLISRQYLLIV----NKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLIT---EFILLIWRFV- 399
Cdd:COG0728  347 LALAAYALGLPAFALVKVLARAfyarQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSalvNALLLLVLLRr 426

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 579673746 400 DITKINVKLNIVSTIQCVIAAVMMFIVLGVVNHYLPPTMY--------ATLLLIAIGIVVYLLLMMTMK 460
Cdd:COG0728  427 RLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLGggllgrllALALLILVGAAVYFALLLLLG 495
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 17-396 2.45e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 43.47  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  17 QLIRTMTPLITIPIISR--AFGPSGVGIVSFSFNIVQYFLMIASVGVQLYFNRVIAKSVNDK--RQLSQQFWDIFVSKLF 92
Cdd:cd12082    8 MLLQTLYNLVDTFFLGRllGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKarRVLVQSIVLAILLGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746  93 LALTVFAMYMVVITIFIDDYYLIFLLQGI--YIIGAALDISWFYA------GTEKFKIPSLSNIVASGIVLSVVVIFVKD 164
Cdd:cd12082   88 LAALLLFFSPLILSLLGAEEEVIELAATYltILILGLPITFLGAVlsgilqGEGDTRTAMIISVLSNLLNILLDPLLIFG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 165 QSDLSLYVFTIAIVTVLNQLPLFIYL-----------KRYISFVSVNWIHVWQLFRSSLAYLLPNGQLNLYTSISCVVLG 233
Cdd:cd12082  168 LGPPELGIAGAALATVISYVIGALLLliylrkgkkilKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 234 LVGTYQQVGIFSNAFNILTVAIIMINTFDLVMIPRIT-KMSIQQSHSLTKTLANNMNIQL-ILTIPMVFGLIAIMPSFYL 311
Cdd:cd12082  248 AFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGqNLGAGNFDRARRITWVALLIGLlIGAVLGLLILLFPEPILSL 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 312 WFFGEEFAS-TVPLMTILAILVLIIPLNMLISRQYLLIVNKIRLYNASITIGAVMNLVLCLVLIY-FYGIYGAAIARLIT 389
Cdd:cd12082  328 FTNDPEFLElAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYlGLGLYGIWLALVIS 407


                 ....*..
gi 579673746 390 EFILLIW 396
Cdd:cd12082  408 LILAALV 414
MATE_epsE_like cd13129
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ...
 238-395 3.25e-04

Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240534 [Multi-domain]  Cd Length: 411  Bit Score: 42.86  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 238 YQQVGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHSLTKTLANNMNIQLILTIPMVFGLIAIMPSFyLWFFGEE 317
Cdd:cd13129  249 YAELGLFNAANQWRQFITFLPATLGNVALPFLAENFGNNEGMFRQTFRSALLFGLGLSLPLGCVFILASQIF-AWLYGKE 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 579673746 318 FASTVPLMTILAILVLIIPLNMLISrQYLLIVNKIRLYNASITIGAVMNLVLCLVLIYFYGIYGAAIARLITEFILLI 395
Cdd:cd13129  328 YGSAAASMRSLAVAAILVGLSVLLG-QIIASSGKIWRGFALNMVWSVIYVAAAYLLLRLYGAPGLALAMSAAYCVLII 404
MATE_like_11 cd13126
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 214-394 6.56e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240531 [Multi-domain]  Cd Length: 396  Bit Score: 41.90  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 214 YLLPNGQLNLYTsiscVVLGLVGTYQQVGIFSNAFNILTVAIIMINTFDLVMIPRITKMSIQQSHSLTKTLANNMNIQLI 293
Cdd:cd13126  208 FVLGQGAAQNSD----LLLGALGSLAAVGALRGAQTLLGPLTILAAGLVTAAVPELARRKDMSPRRRRRAALVLSGVVAA 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 294 LTIPMVFGLIAIMPSFYLWFFGEEFASTVPLMTILAILV-----LIIPLNMLISRQYLLIVNKIRLynasitIGAVMNLV 368
Cdd:cd13126  284 AALVWGLALLLLPDLIGEALLGDVWAGAQALLLPLILAQagaalAVGPAAYLLALGRAKGTLRVNL------VGAPQLLG 357

                        170       180
                 ....*....|....*....|....*.
gi 579673746 369 LCLVLIYFYGIYGAAIARLITEFILL 394
Cdd:cd13126  358 LGLTGALLGGAVGAAWGLALALLLGL 383
PRK10459 PRK10459
MOP flippase family protein;
222-471 1.13e-03

MOP flippase family protein;


Pssm-ID: 236697 [Multi-domain]  Cd Length: 492  Bit Score: 41.17  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 222 NLYTSISCVVLGLVGTYQQVGIFSNAFNILTVAIIMINtfdlvmiPRITKMS------IQQSHS-LTKTLANNMNIQLIL 294
Cdd:PRK10459 224 YLNTNIDTILIGRILGAEVLGGYNLAYNVATVPPMKIN-------PIITRVAfpvfakIQDDTEkLRVGFLKLLSVLGII 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 295 TIPMVFGLIAIMPSFYLWFFGEEFASTVPLMTILAIL----VLIIPLNMLisrqyLLIVNKIRLYNASITIGAVMNLVLC 370
Cdd:PRK10459 297 NFPLLLGLMVVSNNFVPLVFGEKWNSAIPILQLLCIVgllrSVGNPIGSL-----LLAKGRADLSFKWNVFKTFLFIPAI 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579673746 371 LVLIYFYGIYGAAIARLITEFILLIWRFVDITKINVKLNIVSTIQ-----CVIAAVMMFIVLGVV---NHYLPPTMYAtL 442
Cdd:PRK10459 372 VIGGQLAGLIGVALGFLLVQIINTILSYFLMIKPVIGLSYRQYILsiwkpFYLSLPMLIVSYGLGlllKGHLALGMLL-A 450

                        250       260
                 ....*....|....*....|....*....
gi 579673746 443 LLIAIGIVVYLLLMMTMKNQYVWQILRHL 471
Cdd:PRK10459 451 VQVAAGVLAYLLMIVLSRHALVVEVKRQF 479
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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